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Journal articles on the topic 'B lymphocyte'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Milicevic, Novica. "T lymphocytes are necessary for the peripheral phase of B lymphocyte maturation." Srpski arhiv za celokupno lekarstvo 136, Suppl. 2 (2008): 166–70. http://dx.doi.org/10.2298/sarh08s2166m.

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Until recently, B lymphocyte maturation was considered to be independent of the thymus and T lymphocytes. However, using nude animals, which lack the functional thymus, we have shown that T lymphocytes are required for the peripheral phase of B lymphocyte maturation. We showed that the proportion of immature B lymphocyte subsets (CD90highIgMhigh and CD90highIgMlow) was significantly increased, whereas that of mature B lymphocyte subsets (CD90?IgMlow and CD90?IgMhigh) was decreased in the peripheral blood and lymph nodes of nude rats. In addition, the expression of functionally important surfac

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2

Tait, Heidi. "Mechanisms behind the induction of Ttc7 transcription during B lymphocyte development(93.35)." Journal of Immunology 184, no. 1_Supplement (2010): 93.35. http://dx.doi.org/10.4049/jimmunol.184.supp.93.35.

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Abstract Changes in Ttc7 (tetratricopeptide repeat domain 7) transcription have been associated with changes in B lymphocyte signaling through changes in both the lymphopoietic environment and homeostasis of B lymphocyte development in mice with the Ttc7fsn/fsn(flaky skin) mutation. We have demonstrated that young Ttc7fsn/fsn mice exhibit decreased naive B lymphocyte populations in the bone marrow and spleen as compared to their wild type littermates, and that this disparity is exaggerated with age. The Ttc7fsn/fsn mutation also leads to excessive production of harmful B1b lymphocytes causing

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3

Silber, R., CM Farber, E. Papadopoulos, et al. "Glutathione depletion in chronic lymphocytic leukemia B lymphocytes." Blood 80, no. 8 (1992): 2038–43. http://dx.doi.org/10.1182/blood.v80.8.2038.2038.

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Abstract Glutathione (GSH) content may be the major determinant of a cell's sensitivity to cytotoxic alkylating agents. In the present study, the GSH concentration was determined in lymphocytes isolated from the blood of normal subjects and patients with chronic lymphocytic leukemia (CLL). Comparable levels were found in both types of cells. Incubation for 20 hours led to a decrease in GSH to 51% of baseline values in CLL B cells. Under the same conditions, normal B- or T-lymphocyte GSH content remained constant. GSH depletion was shown to be a characteristic of the B-CLL B lymphocyte. It was

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4

Silber, R., CM Farber, E. Papadopoulos, et al. "Glutathione depletion in chronic lymphocytic leukemia B lymphocytes." Blood 80, no. 8 (1992): 2038–43. http://dx.doi.org/10.1182/blood.v80.8.2038.bloodjournal8082038.

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Glutathione (GSH) content may be the major determinant of a cell's sensitivity to cytotoxic alkylating agents. In the present study, the GSH concentration was determined in lymphocytes isolated from the blood of normal subjects and patients with chronic lymphocytic leukemia (CLL). Comparable levels were found in both types of cells. Incubation for 20 hours led to a decrease in GSH to 51% of baseline values in CLL B cells. Under the same conditions, normal B- or T-lymphocyte GSH content remained constant. GSH depletion was shown to be a characteristic of the B-CLL B lymphocyte. It was not found

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Winther, Birgit, Donald J. Innes, John Bratsch, and Frederick G. Hayden. "Lymphocyte Subsets in the Nasal Mucosa and Peripheral Blood during Experimental Rhinovirus Infection." American Journal of Rhinology 6, no. 4 (1992): 149–56. http://dx.doi.org/10.2500/105065892781874621.

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The local cellular response during rhinovirus infection was studied with immunohistochemical staining of lymphocyte subpopulations in the lamina propria of the nasal mucosa (inferior turbinate) in 25 biopsies from volunteers with experimental rhinovirus colds and compared with biopsies from healthy volunteers. Biopsies from rhinovirus infected volunteers, taken either in the early phase of the infection (days 3 and 5) or during convalescence (day 14) were evaluated in a semiquantitative fashion for degree of infiltration. Lymphocyte subpopulations also were counted on coded specimens. During e

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6

Li, Jianxu, Peng Guo, Masayuki Hirano, Brantley Herrin, and Max Cooper. "Cellular and molecular characterization of hagfish VLR-based adaptive immune system (VET2P.1043)." Journal of Immunology 192, no. 1_Supplement (2014): 207.15. http://dx.doi.org/10.4049/jimmunol.192.supp.207.15.

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Abstract Jawless vertebrates have an alternative adaptive immune system in which variable lymphocyte receptors (VLR) are somatically diversified through recombinatorial assembly of leucine-rich repeat cassettes during lymphocyte development. Three VLR loci (VLRA, VLRB, and VLRC) have been defined in lampreys and each is expressed by a distinct lymphocyte population. Lamprey VLRA and VLRC are expressed by T-like lineages of lymphocytes, whereas VLRB is expressed by a B-like lineage of lymphocytes, much like αβ T, γδ T and B cells in jawed vertebrates. Recently we have revised the nomenclature f

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M, Leclerc. "The Sea Star B Lymphocyte." Vaccines & Vaccination Open Access 8, no. 2 (2023): 1–2. http://dx.doi.org/10.23880/vvoa-16000163.

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8

Dorward, D. "Interactions Between Mouse Lymphocytes And Borrelia Burgdorferi, The Infectious Agent Of Lyme Disease." Microscopy and Microanalysis 5, S2 (1999): 1242–43. http://dx.doi.org/10.1017/s143192760001953x.

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Lyme disease is a tick borne, multi-system disorder caused by low density systemic infections with the spirochete Borrelia burgdorferi. Without antimicrobial treatment, mammalian infections with these bacteria are persistent and chronic. Recent studies showed that B. burgdorferi can target, invade, and lyse both cultured and primary human B and T cells. Direct interactions between the spirochetes and lymphocytes also leads to adherence of B and T cell antigens on the surface of significant proportions of the bacteria . Adherent lymphocytic antigens inhibit binding of antibodies to prominent B.

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9

Wang, Hui, Li Hong, Yangyang Tang, et al. "Generation of a B-1 lymphocyte-specific conditional knockout mouse model Bhlhe41tdTomato-Cre." Journal of Immunology 202, no. 1_Supplement (2019): 130.40. http://dx.doi.org/10.4049/jimmunol.202.supp.130.40.

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Abstract B-1 lymphocytes play indispensable roles in defensing a wide range of pathogens prior to adaptive immune response arising. Although several transgenic mouse models targeting different stages of B lymphocytes have been established e.g. Cd19-Cre and Mb1-Cre, a B-1 lymphocyte specific conditional knockout mouse model for illuminating the role of a gene of interest in B-1 lymphocytes is still missing. In this study, we aimed to generate a B-1 lymphocyte-specific knockout mouse model by expression of Cre recombinase under the control of the promoter of Bhlhe41, which is preferentially expr

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10

HASEGAWA, Minoru. "B lymphocyte." Japanese Journal of Clinical Immunology 28, no. 5 (2005): 300–308. http://dx.doi.org/10.2177/jsci.28.300.

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11

Mathur, A., D. H. Conrad, and R. G. Lynch. "Characterization of the murine T cell receptor for IgE (Fc epsilon RII). Demonstration of shared and unshared epitopes with the B cell Fc epsilon RII." Journal of Immunology 141, no. 8 (1988): 2661–67. http://dx.doi.org/10.4049/jimmunol.141.8.2661.

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Abstract Antigenic relationships between the low affinity Fc epsilon R present on murine B and T lymphocytes were studied. A rat mAb (B3B4) and two polyclonal antisera produced by immunizing with the murine B lymphocyte Fc epsilon RII were examined for their ability to inhibit binding of IgE to murine B or T lymphocytes, using an IgE-specific rosette assay. One polyclonal antiserum (goat-anti-mouse Fc epsilon R) inhibited binding of IgE to both B and T lymphocytes, whereas another polyclonal antiserum (rabbit-anti-mouse Fc epsilon R) and the rat mAb inhibited the binding of IgE to B lymphocyte

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12

Williams, Diana L., Grace F. Amborski, and William C. Davis. "Enumeration of T and B lymphocytes in bovine leukemia virus-infected cattle, using monoclonal antibodies." American Journal of Veterinary Research 49, no. 7 (1988): 1098–103. https://doi.org/10.2460/ajvr.1988.49.07.1098.

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SUMMARY Monoclonal antibodies and microfluorimetry were used to determine the absolute number of B and T lymphocytes in the blood of bovine leukemia virus (blv)-infected cows. The blood lymphocyte populations from blv-infected cows were significantly higher than those from blv-negative cows. The increase in the lymphocyte population in 3 blv-infected nonlymphocytotic cows was attributed to a significant increase in the number of T lymphocytes; in 3 blv-infected persistently lymphocytotic cows, the increase was attributed to a significant increase in the number of B and T lymphocytes. One persi

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13

Yang, Jiale, Xiaojian Zhu, and Jun Feng. "The Changes in the Quantity of Lymphocyte Subpopulations during the Process of Sepsis." International Journal of Molecular Sciences 25, no. 3 (2024): 1902. http://dx.doi.org/10.3390/ijms25031902.

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Sepsis remains a global challenge, especially in low- and middle-income countries, where there is an urgent need for easily accessible and cost-effective biomarkers to predict the occurrence and prognosis of sepsis. Lymphocyte counts are easy to measure clinically, and a large body of animal and clinical research has shown that lymphocyte counts are closely related to the incidence and prognosis of sepsis. This review extensively collected experimental articles related to lymphocyte counts since the unification of the definition of sepsis. The article categorizes and discusses the relationship

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14

Foa, R., M. Giovarelli, C. Jemma, et al. "Interleukin 2 (IL 2) and interferon-gamma production by T lymphocytes from patients with B-chronic lymphocytic leukemia: evidence that normally released IL 2 is absorbed by the neoplastic B cell population." Blood 66, no. 3 (1985): 614–19. http://dx.doi.org/10.1182/blood.v66.3.614.614.

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Abstract The capacity of T lymphocytes from patients with B cell chronic lymphocytic leukemia (B-CLL) to release interleukin 2 (IL 2) and interferon (IFN)-gamma was assessed following various stimuli. The spontaneous release of IL 2 and IFN-gamma was practically absent both with B-CLL and normal T lymphocytes. By contrast, after stimulation with phytohemagglutinin (PHA) or with PHA plus 12-O- tetradecanoylphorbol-13-acetate, the production of IL 2 and IFN-gamma by B-CLL T lymphocytes was similar to that of normal T lymphocytes, irrespective of the reversed T lymphocyte subset distribution (OKT

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15

Foa, R., M. Giovarelli, C. Jemma, et al. "Interleukin 2 (IL 2) and interferon-gamma production by T lymphocytes from patients with B-chronic lymphocytic leukemia: evidence that normally released IL 2 is absorbed by the neoplastic B cell population." Blood 66, no. 3 (1985): 614–19. http://dx.doi.org/10.1182/blood.v66.3.614.bloodjournal663614.

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The capacity of T lymphocytes from patients with B cell chronic lymphocytic leukemia (B-CLL) to release interleukin 2 (IL 2) and interferon (IFN)-gamma was assessed following various stimuli. The spontaneous release of IL 2 and IFN-gamma was practically absent both with B-CLL and normal T lymphocytes. By contrast, after stimulation with phytohemagglutinin (PHA) or with PHA plus 12-O- tetradecanoylphorbol-13-acetate, the production of IL 2 and IFN-gamma by B-CLL T lymphocytes was similar to that of normal T lymphocytes, irrespective of the reversed T lymphocyte subset distribution (OKT4/OKT8 ra

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16

Denis, K. A., K. Dorshkind, and O. N. Witte. "Regulated progression of B lymphocyte differentiation from cultured fetal liver." Journal of Experimental Medicine 166, no. 2 (1987): 391–403. http://dx.doi.org/10.1084/jem.166.2.391.

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Lymphoid fetal liver cultures (LFLC) are long-term, nontransformed cultures of early B lymphoid lineage cells which appear developmentally blocked at the pre-B stage in vitro. When injected into severe combined immunodeficient (SCID) mice, cells from LFLC could reconstitute splenic B lymphocytes and serum IgM. T lymphocyte reconstitution was not observed and serum IgG levels were very low. IgG3 was the predominant gamma subisotype in the serum of the LFLC-reconstituted mice, indicating impaired class switching in these B lymphocytes. When thymocytes were coinjected with LFLC, the B lymphocytes

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17

Li, Lijin, Sharon M. Dial, Monika Schmelz, Margaret A. Rennels, and Neil M. Ampel. "Cellular Immune Suppressor Activity Resides in Lymphocyte Cell Clusters Adjacent to Granulomata in Human Coccidioidomycosis." Infection and Immunity 73, no. 7 (2005): 3923–28. http://dx.doi.org/10.1128/iai.73.7.3923-3928.2005.

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ABSTRACT The in situ immunologic response in human coccidioidomycosis remains undefined. To explore this further, pulmonary necrotizing coccidioidal granulomata were examined using immunohistochemical staining for lymphocyte subsets and for the cytokines interleukin-10 (IL-10) and gamma interferon (IFN-γ). Discrete perigranulomatous lymphocytic clusters were seen in eight of nine tissues examined. In these tissues, T lymphocytes (CD3+) significantly outnumbered B lymphocytes (CD20+) in the mantle area of the granulomata (P = 0.028), whereas the clusters were composed of roughly equal numbers o

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18

Nel, A. E., M. W. Wooten, G. E. Landreth, et al. "Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin." Biochemical Journal 233, no. 1 (1986): 145–49. http://dx.doi.org/10.1042/bj2330145.

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Stimulation of peripheral-blood B-lymphocytes with phorbol ester or anti-immunoglobulin demonstrated intracellular translocation of phospholipid/Ca2+-dependent protein kinase (C-kinase) activity from cytosol to membrane fractions. This phenomenon, which was dose- and time-dependent, was found in both normal and chronic-lymphocytic-leukemia B-cells. This suggests that C-kinase-dependent protein phosphorylation may be related to membrane receptor occupation and may therefore be important in B-lymphocyte responses.

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19

Reid, G. K., and D. G. Osmond. "B lymphocyte production in the bone marrow of mice with X-linked immunodeficiency (xid)." Journal of Immunology 135, no. 4 (1985): 2299–302. http://dx.doi.org/10.4049/jimmunol.135.4.2299.

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Abstract CBA/N mice carry an X-linked recessive immunodeficiency (xid) gene manifested by the absence of a B lymphocyte subpopulation, but the manner in which the xid gene exerts its effect on B lymphocyte development is unknown. The production of B lymphocytes in the bone marrow of CBA/N mice has now been compared with that of normal CBA/J mice by using two in vivo assays: immunofluorescence stathmokinetic studies measured pre-B cell proliferation, whereas radioautographic [3H]thymidine labeling was used to evaluate small lymphocyte turnover. Although the total cellularity of CBA/N mouse bone

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20

Janker, Stefanie, Simon Doswald, Roman R. Schimmer, et al. "Targeted Large-Volume Lymphocyte Removal Using Magnetic Nanoparticles in Blood Samples of Patients with Chronic Lymphocytic Leukemia: A Proof-of-Concept Study." International Journal of Molecular Sciences 24, no. 8 (2023): 7523. http://dx.doi.org/10.3390/ijms24087523.

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In the past, our research group was able to successfully remove circulating tumor cells with magnetic nanoparticles. While these cancer cells are typically present in low numbers, we hypothesized that magnetic nanoparticles, besides catching single cells, are also capable of eliminating a large number of tumor cells from the blood ex vivo. This approach was tested in a small pilot study in blood samples of patients suffering from chronic lymphocytic leukemia (CLL), a mature B-cell neoplasm. Cluster of differentiation (CD) 52 is a ubiquitously expressed surface antigen on mature lymphocytes. Al

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Barrington, Robert A., Olga Pozdnyakova, Mohammad R. Zafari, Christopher D. Benjamin, and Michael C. Carroll. "B Lymphocyte Memory." Journal of Experimental Medicine 196, no. 9 (2002): 1189–200. http://dx.doi.org/10.1084/jem.20021110.

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To dissect the influence of CD21/CD35 and FcγRIIB in antigen retention and humoral memory, we used an adoptive transfer model in which antigen-primed B and T lymphocytes were given to sublethally irradiated wild-type mice or mice deficient in CD21/CD35 (Cr2−/−) or FcγRIIB receptors (FcγRIIB−/−). Cr2−/− chimeras showed impaired memory as characterized by a decrease in antibody titer, reduced frequency of antibody secreting cells, an absence of affinity maturation, and significantly reduced recall response. The impaired memory in Cr2−/− chimeras corresponded with the reduced frequency of antigen

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22

Mun, Yeung-Chul, Kyoung-Eun Lee, Jung Mi Kwon, et al. "Establishment of Effective B Lymphocyte Ex Vivo Expansion on Human Cord Blood Using TPO, SCF, FL, IL-4, IL-10, and CD40L." Blood 104, no. 11 (2004): 2882. http://dx.doi.org/10.1182/blood.v104.11.2882.2882.

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Abstract In respect to B lymphocyte-mediated immunity, characteristics of human cord blood are low counts of mature B lymphocytes, deficient expression of CD40L and cytokine production in CD4+ T lymphocytes, defect in the isotype switch of immunoglobulin and the activation of B lymphocytes, and low IgG production of B lymphocytes. These characteristics of the B lymphocyte from human cord blood lead to a delayed B lymphocyte-mediated immune reconstitution and an increased susceptibility to infections after a cord blood transplantation. The mechanism of immunological recostitution after cord blo

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Ishihara, Katsuhiko, Kay Medina, Shin-Ichi Hayashi, et al. "Stromal-Cell and Cytokine-Dependent Lymphocyte Clones Which Span the Pre-B- to B-Cell Transition." Developmental Immunology 1, no. 3 (1991): 149–61. http://dx.doi.org/10.1155/1991/79721.

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Five stromal-cell-dependent lymphocyte clones are described that correspond to late pre-B or early B-cell stages of differentiation.They are useful for determining the molecular requirements for pre-B replication, for studying the stromal cells that supply those factors, and for delineating the final sequence of differentiation events as newly formed lymphocytes prepare to exit the bone marrow. The efficiency of lymphocyte growth at limiting dilution varied substantially on different stromal-cell clones and may reflect functional heterogeneity of stromal cells. Most lymphocyte clones were simi

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Roth, R., and M. J. Mamula. "Trafficking of adoptively transferred B lymphocytes in B-lymphocyte-deficient mice." Journal of Experimental Biology 200, no. 14 (1997): 2057–62. http://dx.doi.org/10.1242/jeb.200.14.2057.

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Many studies have investigated the fate of adoptively transferred lymphocytes in recipient mice, although little is known of the sites where these transferred cells reside at particular time points. Using flow cytometry, we analyzed the trafficking pattern of adoptively transferred naive B cells into the lymphoid organs of syngeneic B-cell-deficient (microMT) mice. Within the first 24 h of transfer, the location of B cells was highly dependent on the mode of B-cell transfer. When B cells were injected subcutaneously into microMT mice, they showed a different trafficking pattern from cells admi

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Chen, Lin-Ying, Julia Y. S. Tsang, Yun-Bi Ni, et al. "Lymphocyte subsets contribute to the degree of lobulitis and ductitis in sclerosing lymphocytic lobulitis of the breast." Journal of Clinical Pathology 69, no. 6 (2015): 527–32. http://dx.doi.org/10.1136/jclinpath-2015-203334.

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AimsSclerosing lymphocytic lobulitis (SLL) of the breast is characterised by lymphocytic lobulitis, ductitis, vasculitis and dense keloidal fibrosis with epithelioid fibroblasts. However, the subsets of the infiltrating lymphocytes and their contribution to disease progression have not been fully explored.MethodsCD20, CD3, CD4, CD8 and regulatory T (Treg) lymphocytes were evaluated in the epithelial and vascular areas in SLL. The relationship between the lymphocyte subset in different regions and the degree of inflammation was analysed.ResultsLymphocytic infiltration was mainly located in peri

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Kaur, Amitinder, Michele Di Mascio, Amy Barabasz, et al. "Dynamics of T- and B-Lymphocyte Turnover in a Natural Host of Simian Immunodeficiency Virus." Journal of Virology 82, no. 3 (2007): 1084–93. http://dx.doi.org/10.1128/jvi.02197-07.

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ABSTRACT Increased lymphocyte turnover is a hallmark of pathogenic lentiviral infection. To investigate perturbations in lymphocyte dynamics in natural hosts with nonpathogenic simian immunodeficiency virus (SIV) infection, the nucleoside analog bromodeoxyuridine (BrdU) was administered to six naturally SIV-infected and five SIV-negative sooty mangabeys. As a measure of lymphocyte turnover, we estimated the mean death rate by fitting a mathematical model to the fraction of BrdU-labeled cells during a 2-week labeling and a median 10-week delabeling period. Despite significantly lower total T- a

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Karabon, L., A. Partyka, L. Ciszak, et al. "Abnormal Expression of BTLA and CTLA-4 Immune Checkpoint Molecules in Chronic Lymphocytic Leukemia Patients." Journal of Immunology Research 2020 (July 28, 2020): 1–12. http://dx.doi.org/10.1155/2020/6545921.

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Chronic lymphocytic leukemia (CLL) is characterized by the peripheral accumulation of neoplastic B cells and is frequently complicated by the systemic immunosuppression associated with an impairment in B and T lymphocyte activation. We hypothesized that the expression of immune checkpoint suppressors B and T lymphocyte attenuator (BTLA) and cytotoxic T lymphocyte antigen (CTLA-4) is disturbed in both lymphocyte subpopulations in CLL. The expression of CTLA-4 and BTLA mRNA was determined by real-time PCR, while CTLA-4 protein expression (surface or intracellular) was estimated in BTLA+ lymphocy

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Diniz, Vinicius Leonardo Sousa, Anuska Marcelino Alvares-Saraiva, Tamires Duarte Afonso Serdan, et al. "Essential metabolism required for T and B lymphocyte functions: an update." Clinical Science 137, no. 10 (2023): 807–21. http://dx.doi.org/10.1042/cs20220869.

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Abstract Lymphocytes act as regulatory and effector cells in inflammation and infection situations. A metabolic switch towards glycolytic metabolism predominance occurs during T lymphocyte differentiation to inflammatory phenotypes (Th1 and Th17 cells). Maturation of T regulatory cells, however, may require activation of oxidative pathways. Metabolic transitions also occur in different maturation stages and activation of B lymphocytes. Under activation, B lymphocytes undergo cell growth and proliferation, associated with increased macromolecule synthesis. The B lymphocyte response to an antige

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Dang, L. H., and K. L. Rock. "Stimulation of B lymphocytes through surface Ig receptors induces LFA-1 and ICAM-1-dependent adhesion." Journal of Immunology 146, no. 10 (1991): 3273–79. http://dx.doi.org/10.4049/jimmunol.146.10.3273.

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Abstract Engagement of the surface Ig receptor with anti-IgM antibodies stimulates murine B lymphocytes to markedly increase their expression of the cell adhesion molecules ICAM-1 and LFA-1. Stimulated B cells display increased homotypic adhesiveness and form spontaneous heterotypic conjugates with T lymphocytes. This latter T-B cell interaction is further enhanced if T cells have been previously activated with phorbol esters. In all cases, the formation of cell-cell conjugates is dependent on LFA-1-ICAM-1-mediated interactions as assessed in mAb blocking experiments. B lymphocytes stimulated

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van Zelm, Menno C., Tomasz Szczepański, Mirjam van der Burg, and Jacques J. M. van Dongen. "Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion." Journal of Experimental Medicine 204, no. 3 (2007): 645–55. http://dx.doi.org/10.1084/jem.20060964.

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The contribution of proliferation to B lymphocyte homeostasis and antigen responses is largely unknown. We quantified the replication history of mouse and human B lymphocyte subsets by calculating the ratio between genomic coding joints and signal joints on kappa-deleting recombination excision circles (KREC) of the IGK-deleting rearrangement. This approach was validated with in vitro proliferation studies. We demonstrate that naive mature B lymphocytes, but not transitional B lymphocytes, undergo in vivo homeostatic proliferation in the absence of somatic mutations in the periphery. T cell–de

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Moysidou, Eleni, Michalis Christodoulou, Georgios Lioulios, et al. "Lymphocytes Change Their Phenotype and Function in Systemic Lupus Erythematosus and Lupus Nephritis." International Journal of Molecular Sciences 25, no. 20 (2024): 10905. http://dx.doi.org/10.3390/ijms252010905.

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Systemic lupus erythematosus (SLE) is a complex autoimmune disease, characterized by considerable changes in peripheral lymphocyte structure and function, that plays a critical role in commencing and reviving the inflammatory and immune signaling pathways. In healthy individuals, B lymphocytes have a major role in guiding and directing defense mechanisms against pathogens. Certain changes in B lymphocyte phenotype, including alterations in surface and endosomal receptors, occur in the presence of SLE and lead to dysregulation of peripheral B lymphocyte subpopulations. Functional changes are ch

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Kurosaki, Tomohiro. "B-lymphocyte biology." Immunological Reviews 237, no. 1 (2010): 5–9. http://dx.doi.org/10.1111/j.1600-065x.2010.00946.x.

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Clark, P., DE Normansell, DJ Innes, and CE Hess. "Lymphocyte subsets in normal bone marrow." Blood 67, no. 6 (1986): 1600–1606. http://dx.doi.org/10.1182/blood.v67.6.1600.1600.

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Abstract Bone marrow aspirates and biopsies from ten normal donors were stained directly with monoclonal antibodies specific for lymphocyte, monocyte, and myeloid antigens, and were analyzed by flow cytometry. To avoid cell loss, lymphocytes were not specifically isolated prior to staining. T cells comprised 46% of aspirate lymphocytes and 22% of biopsy lymphocytes. Further, the Leu-3:Leu-2 ratio of bone marrow T cells was below 1.0. B cells comprised 8% to 11% of bone marrow lymphocytes in both aspirates and biopsies, and there was a substantial percentage of cells in the lymphocyte window th

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Clark, P., DE Normansell, DJ Innes, and CE Hess. "Lymphocyte subsets in normal bone marrow." Blood 67, no. 6 (1986): 1600–1606. http://dx.doi.org/10.1182/blood.v67.6.1600.bloodjournal6761600.

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Bone marrow aspirates and biopsies from ten normal donors were stained directly with monoclonal antibodies specific for lymphocyte, monocyte, and myeloid antigens, and were analyzed by flow cytometry. To avoid cell loss, lymphocytes were not specifically isolated prior to staining. T cells comprised 46% of aspirate lymphocytes and 22% of biopsy lymphocytes. Further, the Leu-3:Leu-2 ratio of bone marrow T cells was below 1.0. B cells comprised 8% to 11% of bone marrow lymphocytes in both aspirates and biopsies, and there was a substantial percentage of cells in the lymphocyte window that was ne

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Hrushik, Amin, Lisa Thomas, Qi Shi, Sudeep Ruparelia, Alfonso Zangardi, and Howard Nash. "Chronic Lymphocytic Leukemia with Bi-Nucleated Lymphocytes." Blood 126, no. 23 (2015): 5285. http://dx.doi.org/10.1182/blood.v126.23.5285.5285.

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Abstract Introduction: B-cell chronic lymphocytic leukemia is one of the common lymphoproliferative disorders in the adult patient population. It is very uncommon to find bi-nucleated lymphocytes as a morphological feature in this disorder. Our patient was diagnosed with CLL and was found to have bi-nucleated lymphocytes in the peripheral smear. The mechanism behind this type of morphological feature of lymphocytes is unknown in CLL, and whether it has prognostic value on disease outcome is undetermined. Case Description: 62 y/o man was referred to hematology oncology after diagnosis of small

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Uher, F., and H. B. Dickler. "Interactions between B lymphocyte subpopulations. Augmentation of the responses of resting B lymphocytes by activated B lymphocytes." Journal of Immunology 140, no. 5 (1988): 1442–47. http://dx.doi.org/10.4049/jimmunol.140.5.1442.

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Abstract Mouse B lymphocytes were fractionated from normal T lymphocyte-depleted spleen cell populations using discontinuous percoll gradients and were stimulated with rabbit F(ab')2 anti-mouse mu-specific antibodies (anti-mu) plus the supernatant of Con A-stimulated rat spleen cells (SN) as a source of lymphokines. The responses of small (mean volume 120 mu 3), dense (greater than 1.087 specific gravity), resting (least spontaneous thymidine incorporation) B lymphocytes were augmented by irradiated (4000 rad), larger (mean volume greater than 170 mu 3), less dense (less than 1.081 specific gr

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Kusunoki, Y., Y. Kodama, Y. Hirai, S. Kyoizumi, N. Nakamura, and M. Akiyama. "Cytogenetic and immunologic identification of clonal expansion of stem cells into T and B lymphocytes in one Atomic-bomb survivor." Blood 86, no. 6 (1995): 2106–12. http://dx.doi.org/10.1182/blood.v86.6.2106.bloodjournal8662106.

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Chromosome aberration frequency in peripheral blood lymphocytes is elevated in radiation-exposed people, and identical karyotypic changes are not infrequently encountered in one blood sample as well as in separate samples from the same donor. Such clonal propagation originates either from a single immature stem cell able to expand and differentiate into several cell types or from a single mature lymphocyte able to expand after antigen stimulation in vivo. In the present study, a total 71 T-lymphocyte and 58 B-lymphocyte colonies were established from one atomic-bomb survivor, who showed a pers

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Nasisse, Mark P., Robert V. English, Mary B. Tompkins, James S. Guy, and Wendy Sussman. "Immunologic, histologic, and virologic features of herpesvirus-induced stromal keratitis in cats." American Journal of Veterinary Research 56, no. 1 (1995): 51–55. http://dx.doi.org/10.2460/ajvr.1995.56.01.51.

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SUMMARY Sequential histologic, immunologic, and virologic features of herpesvirus-induced keratitis were studied in 18 experimentally infected cats. Histologic changes were assessed by use of light microscopy, and the presence of viral antigen, B lymphocytes, and T lymphocytes was verified immunohistochemically. Flow cytometry was used to monitor changes in blood T lymphocytes (CD4 and CD8 homologues) and B lymphocytes. Cellular immunity was assessed by use of the lymphocyte proliferation assay. Development of stromal keratitis was preceded by prolonged absence of corneal epithelium, decreased

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Ali, Mohamed, Harika Dasari, Virginia Van Keulen, Ashley Egan, Tobias Peikert, and Eva M. Carmona. "Microbial Activation of B-cells by Pattern Recognition Receptors Contributes to the Proinflammatory and Profibrotic Milieu in Patients with Idiopathic Pulmonary Fibrosis." Journal of Immunology 202, no. 1_Supplement (2019): 190.20. http://dx.doi.org/10.4049/jimmunol.202.supp.190.20.

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Abstract We hypothesize that B-lymphocytes are conducive to the pathogenesis of idiopathic pulmonary fibrosis (IPF), a progressive and fatal interstitial lung disease. B-lymphocytes aggregate in the lungs of IPF patients to form tertiary lymphoid follicles. How these follicles are formed and their role in the pathogenesis of IPF is not known. Hence, we sought to characterize how the activation of B-lymphocytes from IPF patients may contribute to the disease. Methods IPF patients defined by ATS guidelines were identified and recruited under local IRB #14-004714. B-lymphocytes were then isolated

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Carvalho, Thiago L., Tomaz Mota-Santos, Ana Cumano, Jocelyne Demengeot, and Paulo Vieira. "Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleukin 7−/− Mice." Journal of Experimental Medicine 194, no. 8 (2001): 1141–50. http://dx.doi.org/10.1084/jem.194.8.1141.

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Interleukin 7 is a crucial factor for the development of murine T and B lymphocytes. We now report that, in the absence of interleukin 7, B lymphocyte production takes place exclusively during fetal and perinatal life, ceasing after 7 wk of age. In peripheral organs, however, the pool of B lymphocytes is stable throughout adult life and consists only of cells that belong to the B1 and marginal zone (MZ) compartments. This is accompanied by a 50-fold increase in the frequency of immunoglobulin (Ig)M- and IgG-secreting cells, and the concentration of serum immunoglobulins is increased three- to

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Tashireva, L. A., A. Yu Kalinchuk, T. S. Gerashchenko, O. E. Savelyeva, and V. M. Perelmuter. "Subpopulations of B lymphocytes in patients with breast cancer depending on the PD-L1 status." Bulletin of Siberian Medicine 22, no. 1 (2023): 88–95. http://dx.doi.org/10.20538/1682-0363-2023-1-88-95.

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Aim. To study the association between the functional potency and degree of maturity of B lymphocytes and PD-L1 expression in breast cancer patients.Materials and methods. The study included 37 patients with the morphologically verified diagnosis of invasive breast cancer of no special type (IBC NST). The PD-L1 status was determined immunohistochemically using the Ventana SP142 assay (Roche, USA). Using the multiplex flow cytometry-based assay and high-throughput sequencing of the tumor microenvironment, subpopulations of B lymphocytes and their CD27 and PD1 expression profiles were determined,

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Tang, Mimi L. K., Douglas A. Steeber, Xiu-Qin Zhang, and Thomas F. Tedder. "Intrinsic Differences in L-Selectin Expression Levels Affect T and B Lymphocyte Subset-Specific Recirculation Pathways." Journal of Immunology 160, no. 10 (1998): 5113–21. http://dx.doi.org/10.4049/jimmunol.160.10.5113.

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Abstract Lymphocyte migration into lymphoid organs is regulated by tissue-specific adhesion molecules such as L-selectin and the α4β7 integrin. Whether L-selectin also regulates lymphocyte subset-specific migration into specific lymphoid tissues was examined in this study by comparing the migration of CD4+ T cells, CD8+ T cells, and B cells from L-selectin-deficient and wild-type mice. T cells were the predominant lymphocyte subset entering PLN, MLN, Peyer’s patches, and spleen during short term (1-h) migration assays. However, both B cell and CD4+ and CD8+ T cell entries into PLN, MLN, and Pe

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Wang, Hairong, Cheng-Cheng Guo, Hongyu Chen, Yang Qun-ying, and Zhong-ping Chen. "IMMU-49. DYNAMIC CHANGES AND PROGNOSTIC VALUE OF PERIPHERAL BLOOD LYMPHOCYTE SUBSETS IN INTRACRANIAL GERM CELL TUMORS." Neuro-Oncology 23, Supplement_6 (2021): vi103—vi104. http://dx.doi.org/10.1093/neuonc/noab196.408.

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Abstract OBJECTIVE This study was designed to retrospectively analyze the dynamic changes of peripheral blood lymphocyte subsets and prognosis among patients with intracranial germ cell tumors. METHODS A total of 150 intracranial germ cell tumors patients diagnosed between June 2011 till November 2019 were retrospectively investigated. Peripheral blood total T lymphocytes (CD3+) percentage, T helper/inducible lymphocytes(CD3+CD4+)percentage, T inhibitory/toxic lymphocytes (CD3+CD8+) percentage, B lymphocyte (CD19+) percentage, NK lymphocyte (CD3/CD16+CD56+) percentage, regulatory T cells (CD4+

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Klein da Costa, Bruna, Renata Brant de Souza Melo, Giordani Rodrigues dos Passos, et al. "Unraveling B lymphocytes in CNS inflammatory diseases." Neurology 95, no. 16 (2020): 733–44. http://dx.doi.org/10.1212/wnl.0000000000010789.

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Specific therapies targeting B lymphocytes in multiple sclerosis (MS) have demonstrated reductions in disease activity and disability progression. Several observational studies have also shown the effects of targeting B lymphocytes in other rare CNS inflammatory diseases, such as neuromyelitis optica spectrum disorder (NMOSD) and autoimmune encephalitis (AE). However, some drugs targeting cytokine receptors involved in B-lymphocyte maturation and proliferation resulted in negative outcomes in MS. These apparently conflicting findings have stimulated research on the pathophysiologic mechanisms

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Trueblood, Esther S., Wendy C. Brown, Guy H. Palmer, William C. Davis, Diana M. Stone, and Terry F. McElwain. "B-Lymphocyte Proliferation during Bovine Leukemia VirusInduced Persistent Lymphocytosis Is Enhanced by T-Lymphocyte-Derived Interleukin-2." Journal of Virology 72, no. 4 (1998): 3169–77. http://dx.doi.org/10.1128/jvi.72.4.3169-3177.1998.

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ABSTRACT Bovine leukemia virus (BLV)-induced persistent lymphocytosis is characterized by a polyclonal expansion of CD5+ B lymphocytes. To examine the role of the cytokine microenvironment in this virus-induced B-lymphocyte expansion, the expression of interleukin-2 (IL-2), IL-4, IL-10, and gamma interferon (IFN-γ) mRNA, was measured in stimulated peripheral blood mononuclear cells from persistently lymphocytotic BLV-infected cows, nonlymphocytotic BLV-infected cows, and uninfected cows. IL-2 and IL-10 mRNA expression and IL-2 functional activity were significantly increased when peripheral bl

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Grubeck-Loebenstein, B., H. Kassal, P. P. A. Smyth, K. Krisch, and W. Waldhäusl. "The prevalence of immunological abnormalities in endemic simple goitre." Acta Endocrinologica 113, no. 4 (1986): 508–13. http://dx.doi.org/10.1530/acta.0.1130508.

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Abstract. Thyroid growth stimulating immunoglobulins microsomal antibodies and antibodies against thyroglobulin were determined in patients with simple goitre (n = 20) and controls (n = 6) living in an iodine deficient area. In addition, lymphocytic infiltration of thyroid tissue, the amount of the various lymphocyte subsets (Leu 4+, Leu 3a+, and Leu 2a+ T-cells as well as B1+ B cells) in the thyroid gland, as well as the expression of the histocompatibility antigen HLA-DR on thyrocytes and intrathyroidal T-lymphocytes were examined. Goitrous patients were subdivided into two groups according

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Zhang, Qiao-quan, Yan-fang Zhang, Nian Yu, Xing-jian Lin, and Qing Di. "Differential Diagnosis of Autoimmune Encephalitis from Infectious Lymphocytic Encephalitis by Analysing the Lymphocyte Subsets of Cerebrospinal Fluid." Analytical Cellular Pathology 2019 (December 3, 2019): 1–6. http://dx.doi.org/10.1155/2019/9684175.

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This study is aimed at investigating the lymphocyte subsets of cerebrospinal fluid (CSF) to provide possible differential diagnostic values and better understand the pathophysiological mechanism underlying autoimmune encephalitis (AE) and infectious lymphocytic encephalitis. A series of CD markers, including CD3/4/8/20 representing different types and developmental stages of lymphocytes, were used to count the corresponding subpopulations of CSF from clinical and laboratory confirmed cases of anti-N-methyl-D-aspartate receptor AE (NMDAR-AE), herpes simplex virus encephalitis (HSVE), and tuberc

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Levitt, D., and R. Danen. "Development and regulation of chlamydia-responsive murine B lymphocytes." Journal of Immunology 138, no. 10 (1987): 3468–74. http://dx.doi.org/10.4049/jimmunol.138.10.3468.

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Abstract We have examined characteristics of chlamydia-stimulated mouse B cells as well as cells that regulate polyclonal responses in vitro. B lymphocyte proliferation stimulated by chlamydia arises at a similar time as Escherichia coli lipopolysaccharide (LPS)-induced proliferative responses during ontogeny. In contrast, development of immunoglobulin (Ig)-secreting cells after chlamydia stimulation is delayed by several weeks relative to ontogeny of LPS-inducible plaque-forming cells (PFC). The lack of Ig secretion by immature B cells is not due to a deficiency of Lyb5+ B lymphocytes, since

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Lucivero, G., G. Pierucci, and L. Bonomo. "Lymphocyte subsets in peripheral blood and pleural fluid." European Respiratory Journal 1, no. 4 (1988): 337–40. http://dx.doi.org/10.1183/09031936.93.01040337.

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We have examined the distribution of B and T lymphocytes, T-cells with helper/inducer (T4+) or suppressor/cytotoxic (T8+) phenotypes and a subset of cells with natural killer (NK) activity and positive for the Leu 7 (HNK-1) surface antigen in peripheral blood and in lymphocyte-rich pleural effusions of patients with tuberculosis or malignancies (mesothelioma and lung cancer with pleural metastasis). In individual patients, the percentages of T lymphocytes were uniformly higher in pleural effusions than in peripheral blood; however, lower percentages of B lymphocytes and cells positive for the

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Pereira, Joao, Thomas Beck, and Ana Gomes. "Migration within chemoattractant-defined niches regulates B cell receptor signaling, lymphocyte differentiation and survival (P5087)." Journal of Immunology 190, no. 1_Supplement (2013): 129.8. http://dx.doi.org/10.4049/jimmunol.190.supp.129.8.

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Abstract A critical feature of B and T lymphocytes is their ability to recirculate between lymphoid organs. Cell motility, besides catalyzing encounters between rare lymphocytes and cognate antigens, is also believed to promote lymphocyte survival. For B lymphocytes, however, little is known about how they migrate, and neither it is known if and how motility is required for survival. In previous studies, we demonstrated that B cells are already motile during early stages of development in bone marrow. Using intravital microscopy, we now demonstrate that B cell motility within bone marrow is co

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