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Dissertations / Theses on the topic 'Bacteria infection'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Owen, Rhian Harper. "Investigation of uncultivable bacteria in oral infection." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284845.

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2

Moyà, Anderico Laura. "Deciphering the utility of Galleria mellonella as an infection and toxicity in vivo model." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/671803.

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Galleria mellonella (greater wax moth) is a popular animal model that has been extensively used as an alternative in vivo model for investigating the virulence and pathogenicity of different bacteria. G. mellonella has also been shown to be a suitable model for studying the efficacy and toxicity of various compounds. Recently, this model has been gaining popularity as the larvae are conveniently sized for manipulation, they do not need constant feeding, they are inexpensive to purchase and to breed, they do not require much space or special infrastructure, they present a low biohazard risk, an

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3

Clasper, Jonathan C. "External fixator pin tract infection." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365816.

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4

Nedeljkovic, Marko. "Caractérisation structurale d'un complexe de défense bactérienne." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV067.

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De nos jours, la résistance aux antibiotiques développée par des pathogènes bactériens est de plus en plus répandue, et en conséquent il devient primordial de caractériser de nouvelles cibles bactériennes potentielles. Les alpha2-macroglobulines (α2Ms) sont des inhibiteurs de protéases à large spectre jouant un rôle clé dans l’immunité eucaryote. Ce sont des molécules multi domaines d’environ 1800 résidus qui arborent une séquence en acide nucléique très spécifique appellée « bait site » qui est reconnu et couper par un très grand nombre de protéases. Durant ce clivage, la nouvelle conformatio

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5

Walkden, Heidi. "Bacterial infection of the brain: how bacteria penetrate the CNS by invading peripheral nerves." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/395110.

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Bacterial infections of the central nervous system (CNS), though uncommon, are associated with very high rates of morbidity and mortality. Recent research has also highlighted the correlation between pathogens and chronic diseases of the CNS, such as neurodegenerative disorders, particularly Alzheimer’s disease. Whilst some bacteria can cross the blood-brain/blood-cerebrospinal fluid barriers, to date, other pathways by which bacteria enter the CNS remain largely unknown. Identifying alternative paths by which pathogens can enter the CNS is thus important for developing novel strategies preven

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6

Paro, Mariane Lima de Castro [UNESP]. "Análise do perfil de susceptibilidade antimicrobiana de microrganismos isolados de processos infecciosos bucais." Universidade Estadual Paulista (UNESP), 2003. http://hdl.handle.net/11449/91435.

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Made available in DSpace on 2014-06-11T19:25:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2003Bitstream added on 2014-06-13T20:13:38Z : No. of bitstreams: 1 paro_mlc_me_araca.pdf: 3376248 bytes, checksum: 3cb7c10029858de2655c594466804a68 (MD5)<br>As doenças infecciosas representam uma das principais causas de perda precoce dos dentes, podendo levar a seqüelas graves. Os microrganismos normalmente envolvidos nessas patologias quase sempre pertencem a microbiota autóctone da cavidade bucal e, quase invariavelmente, são de baixa virulência. Assim, o objetivo desse estudo foi avaliar a s

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7

Askar, Mohamed. "Molecular detection of viable bacteria in prosthetic joint infection." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52101/.

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Introduction Diagnosis of periprosthetic joint infection (PJI) can be challenging and discrimination between septic and aseptic loosening might be difficult due to the high rate of false negative bacterial culture results particularly when patients have been on long-term antibiotics. Quantitative polymerase chain reaction (qPCR) seems to be a promising technique with higher sensitivity than conventional microbiological methods in the diagnosis of PJI in such cases. However, this technique has proved to have a lower specificity due to, at least in part, detection of DNA from dead bacteria. Prop

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8

Liversedge, Neil Harvey. "The influence of genital tract bacteria on in vitro fertilisation and subsequent outcome." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390098.

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9

Panta, Utsab R., James A. Joslyn, and Rupal D. Shah. "Pantoea agglomerans bacteremia: A rare case of spontaneous human infection by a plant pathogen in an immunocompromised host." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/170.

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Introduction: Pantoea agglomerans is a Gram negative ubiquitous bacteria commonly isolated from plant surfaces, seeds, fruits and animal/human feces usually introduced to human by ingestion of infected fruits/vegetables, thorn pricks and gastrointestinal translocation in lack of stomach acidity. However, the pathogen can also cause opportunistic human infection especially when the immune system is impaired. The aim of this case report is to investigate clinical features in a patient with P. agglomerans bacteremia and bring attention the opportunistic infection by this rare bacteria. Case prese

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10

Xiujie, Luan. "Study of the bacteria associated with exacerbation of late-onset asthma." Thesis, University of Derby, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323640.

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11

Flores, Garcia César O. "Phage--Bacteria Infection networks: from nestedness to modularity and back again." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53007.

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Bacteriophages (viruses that infect bacteria) are the most abundant biological life-forms on Earth. However, very little is known regarding the structure of phage-bacteria infections. In a recent study we showed that phage-bacteria infection assay datasets are statistically nested in small scale communities while modularity is not statistically present. We predicted that at large macroevolutionary scales, phage-bacteria infection assay datasets should be typified by a modular structure, even if there is nested structure at smaller scales. We evaluate and confirm this hypothesis using the large

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12

Jenkins, Claire. "The human antibody response to infection with verocytotoxin-producing Escherichia coli." Thesis, Open University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340706.

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13

Dempster, Andrew William. "The antimicrobial and bile acid mediated control of Clostridium difficile infection." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52418/.

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Clostridium difficile is an anaerobic, Gram-positive, endospore forming bacillus and is the leading cause of nosocomial infection. Symptoms range from mild diarrhoea to the potentially fatal intestinal complications pseudomembranous colitis and toxic megacolon. The prerequisite for C. difficile infection (CDI) is the perturbation of the healthy microbiota of the gut by broad spectrum antibiotics. It is therefore important to develop therapies which take this in to account, either by minimal disruption of the resident gut microbiota, or by reinstating the protective nature of the gut microbiota

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14

Jones, Grant Steven. "ROLE OF INTRACELLULAR GROWTH DURING THE GASTROINTESTINAL STAGE OF LISTERIA MONOCYTOGENES INFECTION." UKnowledge, 2017. http://uknowledge.uky.edu/microbio_etds/13.

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Listeria monocytogenes is a facultative intracellular bacterium that causes foodborne disease in humans. L. monocytogenes invade the gut mucosa and then disseminate, causing systemic infections associated with high mortality rates in immunocompromised individuals. It is unknown how L. monocytogenes traffic to the mesenteric lymph nodes, which represent an important bottleneck for systemic spread. In addition, little is known about the gastrointestinal stage of infection due to the general resistance of mice to oral infection with L. monocytogenes. Our laboratory developed a novel foodborne mou

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15

Genís, Pagès Sandra. "Use of lactic acid bacteria as a preventive strategy against metritis in dairy cows." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/399509.

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Aproximadament el 40% de les vaques lleteres desenvolupen una malaltia uterina durant el post-part que acaba provocant infertilitat. Alguns estudis indiquen que la infecció uterina, causada principalment per Escherichia coli durant la primera setmana post-part, està associada amb la metritis, caracteritzada per la inflamació de l’úter on la vaca és incapaç d’eliminar els bacteris patògens. El tractament antibacterià tradicional que s’utilitza per contrarestar la metritis pot no ser efectiu en tots els casos, sobretot quan hi ha una inflamació prolongada. El primer estudi està enfocat en ava

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16

Kirby, Jonathan M. "The pathogenesis of Clostridium difficile infection." Thesis, University of Bath, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545329.

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Clostridium difficile is a major problem as the aetiological agent of antibiotic associated diarrhoea. The mechanism by which the bacterium colonises the gut is poorly understood, but undoubtedly involves a myriad of components present on the bacterial surface. The aims of this study were to further define roles for selected surface proteins using a knockout approach, to evaluate the feasibility of surface protein based immunotherapeutics and to obtain structural information using X-ray crystallography. Mutants of cell wall-binding domain (PFam04122) containing proteins CD1036, CD2735, CD2784,

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17

Svensson, Lovisa. "Nitric oxide and bacteria-host interactions in Escherichia coli urinary tract infection." Doctoral thesis, Högskolan i Kalmar, Naturvetenskapliga institutionen, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-29096.

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18

Scott, Elizabeth. "The survival and transfer of potentially pathogenic bacteria from environmental sites and surfaces." Thesis, King's College London (University of London), 1990. https://kclpure.kcl.ac.uk/portal/en/theses/the-survival-and-transfer-of-potentially-pathogenic-bacteria-from-environmental-sites-and-surfaces(23b8e7b3-c7b2-495a-8a6f-0dee3cb90e86).html.

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19

El-Ahmer, Omar Ramadan. "Effects of virus infection and smoking on binding of bacteria to epithelial cells." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/21224.

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The objectives of the study were: (1) to determine if there is a similar pattern of enhanced binding of <I>Neisseria meningitidis</I>, <I>Haemophilus influenzae </I>type b, <I>Staphylococcus aureus, </I>and <I>Bordetella pertussis</I> to RSV subgroup B infected cells as observed with RSV subgroup A infection; (2) to determine if there is increased binding of other species of bacteria associated with meningitis and those associated with secondary respiratory infections or exacerbation of chronic bronchitis to RSV infected cells; (3) to determine if there was similar pattern of increased bacteri

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20

Knap, Primoz. "Host lncRNAs recognize invading bacteria and aid against infection by associating with polysomes." Doctoral thesis, Università degli studi di Trento, 2017. https://hdl.handle.net/11572/368884.

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BACKGROUND: Infections mediated by pathogens, such as bacteria, often interfere with the host process of protein synthesis. This process is the most energy consuming in cells, that is why cells fine-tune it to conserve energy and respond quickly to stress. Thus, translation should be tightly regulated upon bacterial infection, yet the picture is still sketchy at best. Surprisingly, lncRNAs have recently been found to associate with ribosomes and polysomes; however, to date no research exists that addresses their role in translation regulation upon bacterial infection. AIM: The key question I w

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21

Knap, Primoz. "Host lncRNAs recognize invading bacteria and aid against infection by associating with polysomes." Doctoral thesis, University of Trento, 2017. http://eprints-phd.biblio.unitn.it/2677/2/Knap_PhD_disclaimer.pdf.

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BACKGROUND: Infections mediated by pathogens, such as bacteria, often interfere with the host process of protein synthesis. This process is the most energy consuming in cells, that is why cells fine-tune it to conserve energy and respond quickly to stress. Thus, translation should be tightly regulated upon bacterial infection, yet the picture is still sketchy at best. Surprisingly, lncRNAs have recently been found to associate with ribosomes and polysomes; however, to date no research exists that addresses their role in translation regulation upon bacterial infection. AIM: The key question I

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22

Kristo, A. (Aila). "Acute rhinosinusitis during upper respiratory infection in children." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514278720.

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Abstract Acute rhinosinusitis is estimated to be one of the most common diseases in childhood. Still, the diagnostics and clinical relevance of this disease are controversial. Bacterial rhinosinusitis cannot be differentiated from mere rhinitis on clinical grounds alone. Abnormal radiologic findings have been found to be common in child and adult volunteers without sinus symptoms and in adults during viral upper respiratory infection. In children, the results of the few placebo-controlled studies on the benefit of antimicrobial treatment of clinically diagnosed acute rhinosinusitis are contro

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23

Alhariri, Moayad Abdulaziz I. "EVALUATION OF LIPOSOMAL BISMUTH-ETHANEDITHIOL-TOBRAMYCIN FOR TREATMENT OF CYSTIC FIBROSIS PULMONARY PSEUDOMONAS AERUGINOSA INFECTION." Thesis, Laurentian University of Sudbury, 2013. https://zone.biblio.laurentian.ca/dspace/handle/10219/2099.

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The effectiveness of liposomes incorporating bismuth-ethanedithiol and loaded with tobramycin (LipoBiEDT-TOB) at sub-inhibitory concentrations to inhibit the production of quorum sensing signaling molecules and virulence factors induced by P. aeruginosa was evaluated in vitro. In addition, we evaluated the efficacy and safety of free and encapsulated tobramycin in liposomal formulations administered intratracheally to rats chronically infected with P. aeruginosa. LipoBiEDT-TOB significantly reduced the production of quorum sensing signaling molecules and virulence factor secretion compared to

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24

Sahlström, Leena. "Recycled biowaste as a source of infection /." Uppsala : Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/200670.pdf.

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25

Walsh, Keith Thomas. "Relationship between symbiotic and non-symbiotic bacteria during Steinernema (Nematoda) infection of Galleria larvae." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0012/MQ61510.pdf.

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26

Chiruta, Juliana. "Thermal sterilisation kinetics of bacteria as influenced by combined temperature and pH in continuous processing of liquid." Title page, contents and summary only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phc5416.pdf.

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Errata sheet has been pasted onto the front end-paper. Bibliography: leaves 208-217. Outlines a systematic synthesis and testing of continual sterilization design. Principal aim is to evaluate and develop mathematical models for sterilization, undertake experimental studies for determining thermal inactivation effects on continuous processing of a liquid containing contaminant bacteria and compare the data obtained with those predicted by a selected model.

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27

Skovbjerg, Susann. "Inflammatory mediator response to Gram-positive and Gram-negative bacteria in vitro and in middle ear infections." Göteborg : Clinical Bacteriology Section, Dep. of Infectious Medicine, Sahlgrenska Academy , University of Gothenburg, 2010. http://hdl.handle.net/2077/21533.

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28

Wiltshire, Michael David. "The identification of genes important to the growth of Staphylococcus aureus in in vitro models mimicking infection." Thesis, University of Sheffield, 2001. http://etheses.whiterose.ac.uk/14812/.

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Staphylococcus aureus is a major pathogen, which causes a wide range of infections. Despite its obvious clinical importance, little is known about the mechanisms of pathogenesis. An in vitro model mimicking infection was developed in order to identify putative virulence determinants. The model involves the growth of S. aureus in serum under microaerobic conditions. All known virulence factors tested were shown not to be required for growth, or preferentially expressed, in serum. Tn917 transposon libraries of S. aureus were screened to identify genes preferentially expressed in serum, compared

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29

Wilkinson, Nicola Zoe. "The role of Chlamydia trachomatis and other bacteria in reactive arthritis and other inflammatory arthritides : evidence from molecular studies." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321955.

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30

Winter, Theresa [Verfasser]. "A physiological proteomic approach to address infection-related issues of Gram-positive bacteria / Theresa Winter." Greifswald : Universitätsbibliothek Greifswald, 2012. http://d-nb.info/102157435X/34.

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31

KANEDA, TOSHIO, MINORU UEDA, MASAO ITO, et al. "Bacteriological Evaluation of a New Air Turbine Handpiece for Preventing Cross-Contamination in Dental Procedures." Nagoya University School of Medicine, 1994. http://hdl.handle.net/2237/15940.

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32

Jung, Tae Sung. "Studies on pasteurellosis with particular reference to pathogenesis." Thesis, University of Stirling, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311679.

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33

Pacios, Pujadó Sandra. "Cellular Mechanisms that affect Periodontal Destruction induced by Bacteria Infection in Diabetic and Non Diabetic Rats." Doctoral thesis, Universitat Internacional de Catalunya, 2014. http://hdl.handle.net/10803/275965.

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The aim of this study was to evaluate the histologic and cellular response to A.actinomycetemcomitans (A.a) infection, and how diabetes-enhanced TNF-α production and diabetes-enhanced apoptosis contribute to the periodontal disease progression and bone coupling. Conclusion. The results link A. a infection with important characteristics of periodontal destruction and provide new insight into how diabetes aggravates A. a induced periodontal destruction in rats by significantly increasing the inflammatory response, leading to increased bone loss and enhancing apoptosis of gingival epithelial and

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34

Sabri, Jasni. "The intracellular bacteria of the proliferative enteropathies : a comparison of in vitro and in vivo infection." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/29347.

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The intracellular bacteria from naturally occurring porcine proliferation enteropathy were cultured in an <I>in vitro</I> cell culture system, the morphology of the bacteria, the pathogenicity of the organism <I>in vivo</I>, in hamsters, and the morphological events of infection in both cultured cells and hamsters were investigated. The bacteria purified from intestinal lesions of the disease were cultured in rat enterocyte, 1EC-18 cell line. Infection was enhanced by centrifugation of the bacteria onto the cell monolayer incubated at reduced oxygen tension in a microaerobic atmosphere. Howeve

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35

Barbosa, Alzira Maria de Castro. "Chronic immune thrombocytopenic purpura and infection Helicobacter pylori: platelet response to the bacteria elimination of treatment." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16378.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>The Chronic Immune Thrombocytopenic Purpura (ITPc) is a condition caused by autoimmune response resulting awareness of platelets by self antiplatelet antibodies, causing lysis of platelets. Infection with H. pylori has been shown to likely factor for the development of PTIc, with possible platelet response relationship in PTIc after treatment of bacterial eradication. The objective was to evaluate possible effects of eradication of Helicobacter pylori in the number of platelets of patients with PTIC patients at the University Hos

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36

Béland, Paul. "An Optical Biosensor Towards Urinary Tract Infection Diagnosis." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32881.

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We explore a new laboratory technique in the field of urinalysis promising a combination of speed and selectivity in support of urinary tract infection diagnosis. Laboratory experimentation demonstrates long range surface plasmon polaritons (LRSPP) waveguides as a useful biosensor to selectively detect gram negative bacteria or gram positive bacteria in human urine. The biosensor can detect bacteria at concentration of 105 CFU/ml, the internationally recommended threshold for diagnostic of urinary tract infection (UTI). Using a negative control solution at bacterial concentration 1000x higher

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37

Ngwa, Donald Neba, Sanjay K. Singh, Toh B. Gang, and Alok Agrawal. "C-reactive protein, antibiotics, and treatment of pneumococcal infection in mice." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/136.

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C-reactive protein (CRP) binds to Streptococcus pneumoniae through the phosphocholine groups present in the cell wall and subsequently activates the complement system to kill the pathogen. To escape the attack of complement, pneumococci recruit a complement inhibitory protein, factor H, on their surface. It has been shown that CRP protects mice against pneumococcal infection only when injected within 2 hours after administering pneumococci. We hypothesized that CRP is not protective when injected at later times because, by then, factor H is recruited by pneumococci. In the current study, we ev

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38

Paro, Mariane Lima de Castro. "Análise do perfil de susceptibilidade antimicrobiana de microrganismos isolados de processos infecciosos bucais /." Araçatuba : [s.n.], 2003. http://hdl.handle.net/11449/91435.

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Orientador: Elerson Gaetti Jardim Júnior<br>Banca: Ana Maria Pires Soubhia<br>Banca: Hélio Massaioshi Tanimoto<br>Resumo: As doenças infecciosas representam uma das principais causas de perda precoce dos dentes, podendo levar a seqüelas graves. Os microrganismos normalmente envolvidos nessas patologias quase sempre pertencem a microbiota autóctone da cavidade bucal e, quase invariavelmente, são de baixa virulência. Assim, o objetivo desse estudo foi avaliar a susceptibilidade a antimicrobianos de bactérias anaeróbias obrigatórias e anaeróbias facultativas isoladas de processos infecciosos da c

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39

Nowakonski, Angela Von. "Vigilancia laboratorial de bacteriemias por microrganismos gram negativos em pacientes adultos internados no hospital das clinicas, UNICAMP no periodo de 2000-2004: implicação do uso de antimicrobianos selecionados no perfil de resistencia destes mic." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308184.

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Orientadores: Angelica Zaninelli Schreiber, Plinio Trabasso<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-08T13:17:15Z (GMT). No. of bitstreams: 1 Nowakonski_AngelaVon_M.pdf: 1399484 bytes, checksum: ee465090318f9325ffdc02d5497ae055 (MD5) Previous issue date: 2007<br>Resumo: Bacteriemias são ocorrências relacionadas a diferentes processos patológicos e em grande parte associadas a infecções hospitalares. Podem ser causadas por diferentes tipos de microrganismos, sendo os Gram negativos, em especial, os baci

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40

Mathias, Elizabeth. "Exopolysaccharides of the Pseudomonas aeruginosa Biofilm Matrix." Ohio University Honors Tutorial College / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1400069245.

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41

Lindemann, Claudia. "Understanding early transcriptional events in Staphylococcus aureus infection." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:037d5fff-14f7-4587-baf1-39634ec8b9ab.

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Staphylococcus aureus remains an important pathogen, which, due to its capability to develop antimicrobial resistance, imposes an increasing threat to human health. Developing preventive means to decrease disease burden is a major aim. However, the development of an S. aureus vaccine, which would be one strategy to achieve such goals, has been complicated through limited understanding of the bacterium's pathogenic mechanisms. This work uses four approaches to address these limitations: Firstly, a reproducible RNA sequencing based method for the determination of gene transcription by S. aureus

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42

Zahar, Jean-Ralph. "Epidémiologie et conséquences des infections nosocomiales en réanimation : Impact et conséquences de la résistance bactérienne en réanimation." Thesis, Grenoble, 2012. http://www.theses.fr/2012GRENS004/document.

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Les infections nosocomiales à bactéries multi-résistantes sont en constante augmentation en réanimation. Elles ont des conséquences individuelles et collectives majeures. La mortalité en réanimation et les prolongations des durées de séjour sont les deux principales conséquences individuelles connues à ce jour. Plusieurs facteurs confondants rendent l'interprétation des études difficiles, dont l'état sous jacent du patient, la virulence de la bactérie et l'adéquation thérapeutique. Mesurer la part de chacun de ces facteurs et préciser leur responsabilité respective est indispensable pour mobil

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43

Roberts, Jessica L. "Development of an ex-vivo co-culture system to model pulpal infection by Streptococcus anginosus group bacteria." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/55492/.

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A reproducible model of infection of dental tissues by SAG bacteria has been produced which shows attachment patterns of bacteria and the effect on host tissues. This model can be used to further investigate processes involved in endodontic infections, including expression of virulence factors by bacteria and host response from the dental tissues. It may also be used in the future for testing novel antimicrobials for use in treating pulpal disease.

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44

Kauffman, Anne Kathryn Marie. "Demographics of lytic viral infection of coastal ocean vibrio." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/90046.

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Thesis: Ph. D., Joint Program in Biological Oceanography (Massachusetts Institute of Technology, Department of Civil and Environmental Engineering; and the Woods Hole Oceanographic Institution), 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Viral predation on bacteria in the ocean liberates carbon from the particulate fraction, where it is accessible to higher trophic levels, and redirects it to the dissolved fraction, where it supports microbial growth. Although viruses are highly abundant in the ocean little is known about how their interactions wi

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45

Kenny, Jacqueline M. "The characterisation of the antimicrobial activity of honey on clinical isolates of multi-drug resistant bacteria implicated in healthcare associated infections." Thesis, Kingston University, 2013. http://eprints.kingston.ac.uk/28188/.

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Bacterial resistance to antibiotics has presented increasing challenges in healthcare and the management of infection. This has resulted in alternative and traditional products that are used in other cultures being considered as an alternative to topical antibiotics. Honey, particularly Manuka honey is a product which has gained credibility as an antibacterial agent in a healthcare environment. The aim of this study was to investigate the antimicrobial capacity of syrups and honeys from different floral sources on antibiotic sensitive and resistant bacteria isolated from a clinical environment

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Howard-Varona, Cristina. "Phage Fate: Infection Dynamics and Outcomes in a Marine Virus - Host System." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/556856.

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Viruses infecting bacteria (phages) are the most abundant and ubiquitous entities on Earth and likely critical to any ecosystem, as they influence nutrient cycling, mortality and evolution. Ultimately, their impact depends on whether phage—host interactions lead to intracellular phage coexistence (temperate phage) or cell death (lytic phage). Temperate phages in the lysogenic cycle replicate their genome (either integrated into the host chromosome or extrachromosomally), until induced to become lytic, when they create and release progeny via cell lysis. While knowledge on lytic versus lysogeni

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Håkansson, Emelie. "Smitthantering av resistenta bakterier : En fallstudie av ett svenskt universitetssjukhus." Thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-93668.

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Smittsamma sjukdomar kostar det svenska samhället enorma summor varje år. Behandlingen av smittade patienter har tidigare uppskattats till 5-10 miljarder svenska kronor årligen. Vidare estimeras de förebyggande åtgärderna kosta samhället runt en miljard svenska kronor. Detta betyder att det finns en ekonomisk drivkraft för att reducera antalet smittade patienter inom vården, speciellt de fall som är orsakade av resistenta bakterier. Samtidigt pågår det en debatt om resistenta bakterier och antibiotikaförbrukningen i både forskning och media. Resistenta bakterier kan bli ett hot mot vår framtid

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Maung, Nang H. "Intranasal Colonization by Streptococcus Pneumoniae Induces Immunological Protection from Pulmonary and Systemic Infection: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/570.

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Given that Streptococcus pneumoniae can cause life-threatening pulmonary and systemic infection, an apparent paradox is that the bacterium resides, usually harmlessly, in the nasopharynx of many people. Humoral immunity is thought to be the primary defense against serious pneumococcal infection, and we hypothesized that nasopharyngeal colonization of mice results in the generation of an antibody response that provides long-term protection against lung infection. We found that survival of of C57L/6 mice after intranasal inoculation with wild-type serotype 4 strain TIGR4 pneumococci required B c

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Fox, Paige McCarthy. "Characterization of Vancomycin Resistance in Staphylococcus Aureus." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1243.

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In the past decade, Staphylococcus aureus has developed two distinct vancomycin resistance mechanisms. First, the bacterium is capable of generating a thickened, poorly crosslinked cell wall that creates false targets. These targets cause vancomycin to bind at the periphery of the thickened peptidoglycan, allowing normal cell wall formation to continue at the cell membrane. Second, S. aureus has acquired genes from Enterococcus that encode an alternative stem peptide. The genes, known as van genes, alter the target of vancomycin, rendering vancomycin treatment ineffectual.In this work, we atte

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Maldonado, Vázquez Jesús Manuel. "Interferometric biosensors for rapid identification of nosocomial infections." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/403761.

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Esta tesis doctoral se centra en el desarrollo de un nuevo biosensor óptico como una técnica alternativa para la identificación de infecciones nosocomiales con el fin de determinar el tratamiento más eficaz y reducir el uso inespecífico de fármacos antimicrobianos de amplio espectro. Proponemos el uso de un nuevo sensor nanofótonico basado en un dispositivo interferométrico, el biosensor de guías de onda bimodales (BiMW) para un análisis rápido, específico, directo y altamente sensible de los diferentes patógenos asociados a infecciones nosocomiales y su resistencia a múltiples fármacos. En

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