Relevant bibliographies by topics / Bacterial Humans Infusions

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Academic literature on the topic 'Bacterial Humans Infusions'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Bacterial Humans Infusions"

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Felton, T. W., J. Goodwin, L. O'Connor, et al. "Impact of Bolus Dosing versus Continuous Infusion of Piperacillin and Tazobactam on the Development of Antimicrobial Resistance in Pseudomonas aeruginosa." Antimicrobial Agents and Chemotherapy 57, no. 12 (2013): 5811–19. http://dx.doi.org/10.1128/aac.00867-13.

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ABSTRACTManagement of nosocomial pneumonia is frequently complicated by bacterial resistance. Extended infusions of beta-lactams are increasingly being used to improve clinical outcomes. However, the impact of this strategy on the emergence of antimicrobial resistance is not known. A hollow-fiber infection model withPseudomonas aeruginosa(PAO1) was used. Pharmacokinetic (PK) profiles of piperacillin-tazobactam similar to those in humans were simulated over 5 days. Three dosages of piperacillin-tazobactam were administered over 0.5 h or 4 h, with redosing every 8 h. Two initial bacterial densit
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Woodnutt, Gary, and Valerie Berry. "Two Pharmacodynamic Models for Assessing the Efficacy of Amoxicillin-Clavulanate against Experimental Respiratory Tract Infections Caused by Strains of Streptococcus pneumoniae." Antimicrobial Agents and Chemotherapy 43, no. 1 (1999): 29–34. http://dx.doi.org/10.1128/aac.43.1.29.

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ABSTRACT Two models of respiratory tract infection were used to investigate the pharmacodynamics of amoxicillin-clavulanate againstStreptococcus pneumoniae. Eight strains of S. pneumoniae were used in a mouse model in which the animals were infected intranasally and were then treated with a range of doses and dose intervals. The time that the plasma amoxicillin concentration remained above the MIC (T>MIC) correlated well with bacterial killing, such that if T>MIC was below 20% there was no effect on bacterial numbers in the lungs. As T>MIC increased, the response, in terms of decrease
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Thomsen, Henrik H., Nikolaj Rittig, Mogens Johannsen, et al. "Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during LPS-induced inflammation in humans: anticatabolic impact of ketone bodies." American Journal of Clinical Nutrition 108, no. 4 (2018): 857–67. http://dx.doi.org/10.1093/ajcn/nqy170.

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Abstract Background Acute inflammation, and subsequent release of bacterial products (e.g. LPS), inflammatory cytokines, and stress hormones, is catabolic, and the loss of lean body mass predicts morbidity and mortality. Lipid intermediates may reduce protein loss, but the roles of free fatty acids (FFAs) and ketone bodies during acute inflammation are unclear. Objective We aimed to test whether infusions of 3-hydroxybutyrate (3OHB), FFAs, and saline reduce protein catabolism during exposure to LPS and Acipimox (to restrict and control endogenous lipolysis). Design A total of 10 healthy male s
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Hla, Thel Khin, Joshua Osowicki, Sam Salman, et al. "Study protocol for controlled human infection for penicillin G againstStreptococcus pyogenes: a double-blinded, placebo-controlled, randomised trial to determine the minimum concentration required to prevent experimental pharyngitis (the CHIPS trial)." BMJ Open 12, no. 12 (2022): e064022. http://dx.doi.org/10.1136/bmjopen-2022-064022.

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IntroductionRegular intramuscular benzathine penicillin G injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. As the pharmacological correlate of protection remains unknown, it is difficult to recommend changes to this established regimen. Determining the minimum effective penicillin exposure required to preventStreptococcus pyogenesinfection will accelerate development of new long-acting penicillins for RHD prevention as well as inform opportunities to improve existing regimens. The CHIPS trial will address this knowledge gap by directl
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Gill, Christian M., Kamilia Abdelraouf, and David P. Nicolau. "1244. Assessment of the In Vivo Activity of Human-Simulated Exposure of WCK 4282 (High Dose Cefepime [FEP]-Tazobactam [TZB]) against Enterobacterales (EB) and Pseudomonas aeruginosa (PA) in the Neutropenic Murine Thigh Infection Model." Open Forum Infectious Diseases 7, Supplement_1 (2020): S640—S641. http://dx.doi.org/10.1093/ofid/ofaa439.1429.

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Abstract Background Carbapenems are often used for infections due to extended-spectrum-β-lactamase (ESBL) and cephalosporinase (CSase)-producers. As increased carbapenem utilization is associated with the development of carbapenem resistance, antimicrobial stewardship has targeted non-carbapenem options. WCK 4282 (FEP 2 g-TZB 2 g) offers pharmacodynamically optimized TZB exposure and demonstrated potent activity in vitro against ESBL-phenotype isolates. We describe the pharmacodynamics of a WCK 4282 human-simulated regimen (HSR) in the neutropenic murine thigh model. Methods 19 clinical strain
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Pérez-Pérez, J. Abraham, David Espinosa-Victoria, Hilda V. Silva-Rojas, and Lucía López-Reyes. "DIVERSITY OF CULTURABLE BACTERIAL MICROBIOTA OF THE Eisenia foetida DIGESTIVE TRACT." Revista Fitotecnia Mexicana 41, no. 3 (2018): 255–64. http://dx.doi.org/10.35196/rfm.2018.3.255-264.

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Bacteria are an unavoidable component of the natural earthworm diet; thus, bacterial diversity in the earthworm gut is directly linked to decomposition of organic matter and development of the surrounding plants. The aim of this research was to isolate and to identify biochemically and molecularly the culturable bacterial microbiota of the digestive tract of Eisenia foetida. Earthworms were sourced from Instituto de Reconversión Productiva y Bioenergética (IRBIO) and Colegio de Postgraduados (COLPOS), México. Bacterial isolation was carried out on plates of Brain Heart Infusion (BHI) culture m
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Martins, Káthia Santana, Lorena Tirza de Assis Magalhães, Jeferson Geison de Almeida, and Fábio Alessandro Pieri. "Antagonism of Bacteria from Dog Dental Plaque against Human Cariogenic Bacteria." BioMed Research International 2018 (November 4, 2018): 1–6. http://dx.doi.org/10.1155/2018/2780948.

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Dental caries are a process of demineralization and destruction of human teeth. They originate through many factors and are associated with biofilm formation, which consists of bacteria adhered to the teeth that form a structurally and functionally organized mass called dental plaque. Both the presence ofStreptococcus mutansand the frequent consumption of sucrose correlate with a higher prevalence of caries in humans. In dogs, however, the incidence of this disease is low, due to factors such as differences in dental microbiota and/or their low consumption of sucrose. This work evaluated the a
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Quereda, Juan J., Empar García-Roselló, Marta Barba, et al. "Use of Probiotics in Intravaginal Sponges in Sheep: A Pilot Study." Animals 10, no. 4 (2020): 719. http://dx.doi.org/10.3390/ani10040719.

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Sheep estrous synchronization is mainly based on progestagen-impregnated sponges which could cause vaginitis. Several species of Lactobacillus used as probiotics are commonly used in the treatment or prevention of urogenital infections in humans. However, no studies have been performed to analyze the potential use of probiotics to prevent urogenital infections in sheep. A randomized controlled clinical trial was conducted with 21 one-year-old ewes to develop a model of probiotic infusion in vaginal sponges in order to study their influence in ewe’s vaginal microbiota, general health status, fe
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Cutler, N. R., J. Vincent, S. S. Jhee, et al. "Penetration of trovafloxacin into cerebrospinal fluid in humans following intravenous infusion of alatrofloxacin." Antimicrobial Agents and Chemotherapy 41, no. 6 (1997): 1298–300. http://dx.doi.org/10.1128/aac.41.6.1298.

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A single-dose study was conducted to determine concentrations of trovafloxacin (CP-99,219) achieved in the cerebrospinal fluid (CSF) relative to those in the serum of healthy subjects after intravenous infusion of alatrofloxacin (CP-116,517), the alanyl-alanyl prodrug of trovafloxacin. Twelve healthy subjects were administered single doses of alatrofloxacin at a trovafloxacin equivalent of 300 mg as an intravenous infusion over 1.0 h. CSF samples were taken by lumbar puncture at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, and 24 h after the start of the infusion; each subject was sampled at only one ti
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Veloso, T. R., M. Amiguet, V. Rousson, et al. "Induction of Experimental Endocarditis by Continuous Low-Grade Bacteremia Mimicking Spontaneous Bacteremia in Humans." Infection and Immunity 79, no. 5 (2011): 2006–11. http://dx.doi.org/10.1128/iai.01208-10.

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ABSTRACTTransient high-grade bacteremia following invasive procedures carries a risk of infective endocarditis (IE). This is supported by experimental endocarditis. On the other hand, case-control studies showed that IE could be caused by cumulative exposure to low-grade bacteremia occurring during daily activities. However, no experimental demonstration of this latter possibility exists. This study investigated the infectivity in animals of continuous low-grade bacteremia compared to that of brief high-grade bacteremia. Rats with aortic vegetations were inoculated withStreptococcus intermediu
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Book chapters on the topic "Bacterial Humans Infusions"

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Hottinger, Andreas F., Hervé Ghesquières, and Mehdi Touat. "Neurological complications of cell therapies in haematological malignancies." In Oxford Textbook of Neurohaematology, edited by Tracy Batchelor, Joshua P. Klein, Andrés José María Ferreri, and Lisa M. DeAngelis. Oxford University PressOxford, 2024. http://dx.doi.org/10.1093/med/9780198884903.003.0009.

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Abstract Cell therapies comprising haematological stem cell transplantation (HCT) and adoptive T-cell therapies (ACT) have become an essential part in the treatment of an expanding range haematological and non-haematological conditions. HCT involves the intravenous infusion of haematopoietic progenitor cells from the patient (autologous) or from a human leucocyte antigen (HLA)-matched donor (allogeneic). Prior to HTC, the patient typically undergoes high-dose preparative chemotherapy to eradicate residual malignant cells and suppress the immune system. After allogeneic HCT, it is essential to
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