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Dissertations / Theses on the topic 'Bacterial infections Diagnosis'

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Published: 4 June 2021
Last updated: 25 July 2025

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1

Karpati, Ferenc. "Bacterial colonisation and infection of the lower airways in cystic fibrosis : a microbiological and clinical study /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4628-0/.

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2

Irwin, Adam. "The diagnosis of serious bacterial infections in the children's Emergency Department." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/2005599/.

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Background Acute febrile illness is a common presentation to the children’s Emergency Department (ED). Difficulty discriminating between Serious Bacterial Infections (SBI) and self-limiting infections results in delayed treatment of SBI, and over-treatment of self-limiting infections. Aims/Objectives To define the aetiology of bacteraemia in the children’s ED, to evaluate a universal molecular diagnostic for the diagnosis of bacteraemia, and to derive and validate risk prediction models for SBI in this setting. Methods A prospective diagnostic accuracy study of clinical and biomarker variables
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3

Werner, Maria. "Blood culture negative endocarditis /." Göteborg : Department of Infectious Diseases, The Sahlgrenska Academy at Göteborg University, 2006. http://hdl.handle.net/2077/776.

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4

Collins, Ann. "A review and retrospective study of some major bacterial orofacial infections." Thesis, The University of Sydney, 1990. http://hdl.handle.net/2123/4209.

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History has recorded the antiquity of serious infections in the region of the head and neck. Today, our community still experiences major life-threatening infections in these anatomical locations, which pose significant management difficulties to the oral and maxillofacial surgeon. The aim of this thesis is to review the aetiology, diagnosis and treatment of some bacterial infections involving structures of the head and neck. Such infections may spread, causing serious complications with severe morbidity and occasionally death. This theses deals only with infections of bacterial origin and doe
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5

Collins, Ann. "A review and retrospective study of some major bacterial orofacial infections." University of Sydney, 1990. http://hdl.handle.net/2123/4209.

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Master of Dental Surgery<br>History has recorded the antiquity of serious infections in the region of the head and neck. Today, our community still experiences major life-threatening infections in these anatomical locations, which pose significant management difficulties to the oral and maxillofacial surgeon. The aim of this thesis is to review the aetiology, diagnosis and treatment of some bacterial infections involving structures of the head and neck. Such infections may spread, causing serious complications with severe morbidity and occasionally death. This theses deals only with infections
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6

Czilwik, Gregor [Verfasser], and Roland [Akademischer Betreuer] Zengerle. "LabDisk employing nested PCR for rapid point-of-care diagnosis of bacterial infections." Freiburg : Universität, 2016. http://d-nb.info/1122831536/34.

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7

Autio, T. (Timo). "Development and diagnostics of bacterial acute rhinosinusitis in young adults." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526214726.

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Abstract Acute rhinosinusitis (ARS) is a common condition often treated with antibiotics, even though the cause is usually viral. Despite the commonness of ARS, there is limited evidence on the development and diagnosis of bacterial cases. So far, we lack prospective studies where the bacterial cause would have been confirmed with a bacterial culture of the paranasal sinus aspirate. The purpose of the study was to investigate the course of ARS with a prospective inception cohort study among young adults with ARS, using sequential and standardized methods. To differentiate viral and bacterial A
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8

Launay, Elise. "Méthodologies d’évaluation de l’optimalité des soins : exemples des délais diagnostiques et des infections bactériennes sévères de l’enfant." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB134/document.

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Les objectifs de cette thèse étaient de produire des connaissances nouvelles sur les méthodologies d’évaluation de l’optimalité des soins avec l’exemple des délais diagnostiques et des infections bactériennes sévères de l’enfant (IBS). Nous avons mis en évidence, dans deux revues systématiques de la littérature, que les points méthodologiques potentiellement associés à des risques de biais et d’obstacles à la transportabilité des résultats étaient rarement rapportés dans les études primaires sur les délais diagnostiques ou rarement évalués par les auteurs de méta-analyses. Nous avons donc cons
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9

Armour, Patricia. "Usefulness of the Captia Syphilis IgG EIA test method and reverse algorithm for detection of syphilis infection in a public health setting." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5341.

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Syphilis, a systemic sexually transmitted disease, is on the rise in the US, with infection rates the highest recorded since 1994 according to the CDC. Useful laboratory testing is an important diagnostic tool for determining individual syphilis infection and preventing community-wide disease spread. The purpose of this study was to determine the usefulness of a specific automated treponemal test method, the CaptiaTM Syphilis IgG EIA, and the syphilis reverse algorithm interpretation for detecting syphilis infection among patients seeking care in a public health clinic. The study employed a r
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10

Mir, de Simón Bernat. "Multiplex optical detection system for prosthetic joint infection diagnosis." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/400573.

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La infección de prótesis articular (IPA) es una patología de difícil manejo terapéutico que produce tanto morbilidad física como psicológica en los pacientes afectados y, además, está asociada con un impacto económico sustancial sobre el sistema sanitario. Su incidencia oscila entre 0.8 y 2.4% dependiendo de la articulación afectada, tales como la muñeca, el hombro, el codo, la rodilla o la cadera. A pesar de la baja incidencia de la IPA, el coste económico que se desprende ella es considerable (566M$ en 2009 para el sistema sanitario Americano). Por otro lado, un reconocimiento y manejo adecu
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11

Tsukimoto, Eliane Rodrigues. "Avaliação de novos métodos para a cultura de anaeróbios." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-27092018-121302/.

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INTRODUÇÃO: As infecções por bactérias anaeróbias são geralmente de origem endógena, polimicrobianas e mistas. Devido a sua natureza fastidiosa, essas bactérias necessitam de uma prévia incubação em meios líquidos enriquecidos, como o caldo Thioglicolato (CT) para serem recuperadas, o isolamento desses microrganismos é trabalhoso e o tempo de resposta - TAT (turn around time) estendido desse exame pode estar associado a falhas terapêuticas e ao aumento da resistência bacteriana. A cultura de anaeróbios (CANA) ainda é um desafio para os laboratórios clínicos de rotina e novas estratégias para d
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12

Thalme, Anders. "Infectious endocarditis, aspects on pathogenesis, diagnosis and prognosis /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-361-2/.

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13

Strålin, Kristoffer. "Diagnostic methods for bacterial etiology in adult community-acquired pneumonia /." Linköping : Linköpings universitet, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med918s.pdf.

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14

Akram, Ahsan-Ul-Haq Ramzan Khushi. "Optical Smartprobes to diagnose pulmonary bacterial infections and lung cancer." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25803.

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The work in this thesis describes the approaches taken to advance the field of pulmonary optical molecular imaging for the diagnosis of unexplained pulmonary opacities in the critically ill patient where bacterial causes are suspected and the investigation of pulmonary nodules and masses where lung cancer is suspected. The bacterial work includes the development and assessment of a multivalent fluorescently labelled antimicrobial peptide fragment that allows for the in vivo in situ detection of bacteria in the distal lung. This Smartprobe (chapter 3), called NBD-UBIdend remains specific for ba
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15

Zhao, Huifang. "Improved Methods of Sepsis Case Identification and the Effects of Treatment with Low Dose Steroids: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/529.

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Sepsis is the leading cause of death among critically ill patients and the 10th most common cause of death overall in the United States. The mortality rates increase with severity of the disease, ranging from 15% for sepsis to 60% for septic shock. Patient with sepsis can present varied clinical symptoms depending on the personal predisposition, causal microorganism, organ system involved, and disease severity. To facilitate sepsis diagnosis, the first sepsis consensus definitions was published in 1991 and then updated in 2001. Early recognition of a sepsis patient followed with timely and app
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16

Prudent, Elsa. "Applications de l'hybridation in situ en fluorescence et stratégies moléculaires pour le diagnostic des infections bactériennes." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0253/document.

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Une partie de ce travail de thèse a consisté à appliquer les méthodes de FISH pour l’étude de trois bactéries pathogènes intracellulaires. La viabilité de Bartonella henselae a été évaluée à partir de ganglions de patients atteints de la maladie des griffes du chat (CSD). Le faible taux d’ARN détecté par biologie moléculaire, la stérilité des cultures, l'absence de détection par analyses histologiques et FISH confirment que B. henselae n'est pas ou rarement viable dans les ganglions de patients atteints de CSD. Tropheryma whipplei, l’agent de la maladie de Whipple, a été identifié et localisé
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17

Fitzgerald, Sarah E. M. D. "A Meta-Analysis of the Diagnostic Performance of Procalcitonin in the Diagnosis of Serious Bacterial Infection in Pediatric Febrile Neutropenia." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342544799.

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18

Eiderbrant, Kristina. "Development of quantitative PCR methods for diagnosis of bacterial vaginosis and vaginal yeast infection." Thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68269.

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Vaginitis is a vaginal infection which affects many women all over the world. The disorder is characterized by an infection of the vaginal area which can cause problems like abnormal vaginal discharge, itching and redness. The two most common causes of vaginitis are bacterial vaginosis and Candida vaginitis. The prevalence of bacterial vaginosis in Sweden is around 10-20 % and approximately 75 % of all women will once in their lifetime suffer from vaginal yeast infection. The clinical symptoms of vaginal infections are not specific and the diagnosis methods of bacterial vaginosis and Candida v
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19

Béland, Paul. "An Optical Biosensor Towards Urinary Tract Infection Diagnosis." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32881.

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We explore a new laboratory technique in the field of urinalysis promising a combination of speed and selectivity in support of urinary tract infection diagnosis. Laboratory experimentation demonstrates long range surface plasmon polaritons (LRSPP) waveguides as a useful biosensor to selectively detect gram negative bacteria or gram positive bacteria in human urine. The biosensor can detect bacteria at concentration of 105 CFU/ml, the internationally recommended threshold for diagnostic of urinary tract infection (UTI). Using a negative control solution at bacterial concentration 1000x higher
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20

Fjaertoft, Gustav. "CD64 (FcγRI) Expression on Neutrophil Granulocytes : A Diagnostic Marker of Acute Bacterial Infections". Doctoral thesis, Uppsala University, Department of Women's and Children's Health, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5974.

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<p><b>Background. </b>Newborn infants, especially preterm infants, have an increased susceptibility to serious and overwhelming bacterial as well as fungal infections. Symptoms of septicaemia in especially the very preterm neonates are vague and unspecific. No really good biochemical parameter exists today that can confirm or exclude the existence of neonatal septicaemia. The access to such a test in neonates would be most valuable, not only to assure early institution of effective antibiotic therapy when needed, but also to avoid unnecessary use of antibiotics, thereby reducing the risk of fu
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21

Westling, Katarina. "Viridans group streptococci septicaemia and endocarditis : molecular diagnostics, antibiotic susceptibility and clinical aspects /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-364-7/.

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22

Brennecke, Johannes. "Molecular diagnostics of the bacterial response to antibiotic therapy." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28843.

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Bacterial bloodstream infections (BSIs) are a major healthcare problem causing high mortality and economic cost. BSIs require an immediate initiation of antibiotic therapy as any delay is associated with a mortality increase. With the emergence of antimicrobial resistance, the choice of the appropriate antibiotic becomes increasingly difficult, thus creating an urgent need for new diagnostics, ideally to be done at the point of care. The current gold standard is blood culture with subsequent susceptibility testing although several molecular methods have recently entered the market. However, in
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23

Milcent, Karen. "Outils diagnostiques pour la reconnaissance des infections bactériennes sévères chez les nourrissons fébriles âgés de moins de trois mois consultant aux urgences pédiatriques." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS224/document.

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Les nourrissons âgés de moins de trois mois ont la particularité d’être à relativement haut risque d’infections bactériennes sévères (IBS), majoritairement représentées par les infections urinaires et en particulier celles plus invasives (IBI) que sont les méningites et les bactériémies. On ne dispose actuellement pas d’outil suffisamment fiable et d’un rapport coût-bénéfice bien évalué pour différencier les nourrissons fébriles porteurs d’une affection virale banale de ceux porteurs d’une infection bactérienne.Le travail doctoral avait pour objectifs d’évaluer l’épidémiologie et les pratiques
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24

Sweeney, Robin E., Elizabeth Budiman, and Jeong-Yeol Yoon. "Mie scatter spectra-based device for instant, contact-free, and specific diagnosis of bacterial skin infection." NATURE PUBLISHING GROUP, 2017. http://hdl.handle.net/10150/624898.

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Rapid and specific diagnostic techniques are needed to expedite specific treatment of bacterial skin infections with narrow-spectrum antibiotics, rather than broad-spectrum. Through this work a device was developed to determine the presence of and species responsible for a bacterial skin infection using differences in Mie scatter spectra created by different bacterial species. A 650 nm LED at five different incident angles is used to illuminate the tissue, with Mie scatter being detected by PIN photodiodes at eight different detection angles. Mie scatter patterns are collected at all photodiod
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25

Edouard, Sophie. "Evaluation des techniques de diagnostic des infections liées aux bactéries intracellulaires." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5045.

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Notre objectif est d’évaluer la sérologie, la biologie moléculaire et la culture pour le diagnostic des infections liées aux bactéries intracellulaires.La sérologie occupe une place importante dans le dépistage, le suivi et le monitoring des patients présentant une infection cardiovasculaire à C. burnetii ou Bartonella. Cependant, nous avons montré quelques limites aux seuils précédemment établis pour le diagnostic d’endocardite. Ce travail suggère que les faibles titres d’anticorps n'excluent pas le diagnostic de l'infection cardiovasculaire chez les patients ayant des facteurs prédisposant e
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26

Surujon, Defne. "Computational approaches in infectious disease research: Towards improved diagnostic methods." Thesis, Boston College, 2020. http://hdl.handle.net/2345/bc-ir:109089.

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Thesis advisor: Kenneth Williams<br>Due to overuse and misuse of antibiotics, the global threat of antibiotic resistance is a growing crisis. Three critical issues surrounding antibiotic resistance are the lack of rapid testing, treatment failure, and evolution of resistance. However, with new technology facilitating data collection and powerful statistical learning advances, our understanding of the bacterial stress response to antibiotics is rapidly expanding. With a recent influx of omics data, it has become possible to develop powerful computational methods that make the best use of growin
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Fjaertoft, Gustav. "CD64 (Fcg[gamma]RI) expression on neutrophil granulocytes a diagnostic marker of acute bacterial infections /." Uppsala : Uppsala Universitet, 2005. http://uu.diva-portal.org/smash/get/diva2:167060/FULLTEXT01.

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28

Hanna, William J. "IL-27: A Novel Biomarker in Predicting Bacterial Infection Among the Critically Ill." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427983618.

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29

van, Der Walt Elise. "Cost-effectiveness of different screening and diagnostic strategies for sexually transmitted infections and bacterial vaginosis in women." Master's thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/33088.

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Genital inflammation associated with sexually transmitted infections (STIs) and Bacterial Vaginosis (BV) is considered a key driver in the HIV/AIDS epidemic. A new rapid point-of-care (POC) test that detects genital inflammation in women was recently developed by researchers at the University of Cape Town. The objective of this study was to establish the cost-effectiveness of this novel intervention in comparison to other relevant screening and diagnostic strategies for the management of STIs and BV in women. It follows prior research on the cost and affordability of national implementation of
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30

Doud, Melissa S. "A Multi-Faceted Diagnostic Approach to Lung Infections in Patients with Cystic Fibrosis." FIU Digital Commons, 2010. http://digitalcommons.fiu.edu/etd/166.

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One in 3,000 people in the US are born with cystic fibrosis (CF), a genetic disorder affecting the reproductive system, pancreas, and lungs. Lung disease caused by chronic bacterial and fungal infections is the leading cause of morbidity and mortality in CF. Identities of the microbes are traditionally determined by culturing followed by phenotypic and biochemical assays. It was first thought that the bacterial infections were caused by a select handful of bacteria such as S. aureus, H. influenzae, B. cenocepacia, and P. aeruginosa. With the advent of PCR and molecular techniques, the polymicr
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31

Falk, Lars. "Urethritis and cervicitis with special reference to Chlamydia trachomatis and Mycoplasma genitalium : diagnostic and epidemiological aspects /." Linköping : Univ, 2004. http://www.bibl.liu.se/liupubl/disp/disp2004/med858s.pdf.

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32

Backus, Keriann Marie. "Incorporation of trehalose analogues into Mycobacterium tuberculosis : antigen 85 and probes of bacterial infection." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:882d8560-c0d3-471b-a896-224a6b22a0f0.

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Diagnoses of tuberculosis, 'TB,' currently rely upon non-specific techniques such as X-ray exams and acid-fast microscopy. Improved diagnostics would preferably consider specific bacterial processes to provide real-time readouts of disease burden and response to chemotherapy. This dissertation presents the cell-wall incorporation of trehalose analogues (fluorescent and radioactive) by the mycobacterial antigen 85 enzymes as a novel method to label the causative bacteria of TB, Mycobacterium tuberculosis (Mtb). The trehalose mycolyltransesterase enzymes (antigens 85A, B, and C (Ag85)) serve as
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33

Moore, Luke Stephen Prockter. "Rapid infection diagnostics in the context of augmented care : investigating their role in antimicrobial prescribing and bacterial resistance." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/55116.

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Introduction: Augmented care is a potentially significant reservoir of antimicrobial resistance (AMR). In the context of augmented care, this thesis investigates AMR variation and its drivers, barriers to optimising antimicrobial use, and the role of rapid infection-related diagnostics in addressing this. Methods: Mixed methods were used. AMR and antimicrobial consumption were quantitatively analysed, and driving factors explored using (i) statistical algorithms and (ii) thematic analysis of semi-structured interviews. As a case study, the role of rapid microbiology diagnostics was investigate
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34

MATTIONI, MARCHETTI VITTORIA. "Multidrug-resistant (MDR) and Extensively Drug-resistant (XDR) Gram-negative bacteria of clinical interest: laboratory diagnosis, clinical management and infection control." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1301308.

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Antimicrobial resistance (AMR) represents one of the major 21st century public health tasks: its increasing has reduced the effective prevention and treatment strategies against infection events. The problem of AMR is especially urgent for Gram-negative bacteria, on which an over-/inappropriate use (incorrect choices, inadequate dosing, and poor adherence to treatment guidelines) of antibiotics have acted as a selective pressure, favouring the survival and multiplication of strains with acquired antibiotic-resistant traits. The aim of my PhD research were: i) to perform an evaluation and chara
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35

Russo, Lorenzo. "Designing advanced nanomaterials for next generation in vitro diagnostics: development of optical and electrochemical biosensors for determination of viral and bacterial infections based on hollow AuAg nanoparticles." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/666751.

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En esta tesis doctoral. El dibujo racional de nanomateriales avanzados con propiedades controladas se aplicó para su empleo en biosensing, y condujo al desarrollo de dos plataformas diagnosticas para la determinación de infecciones virales y bacterianas. Primero, se desarrolló un método sintético altamente reproducible y robusto para la producción de nanoshells de una aleación AuAg monodispersas basado en remplazamiento galvánico. El protocolo descrito permite el controlo preciso sobre la morfología de las partículas, en términos de grosor de la capa externa y de tamaño del vacío interior, la
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36

André, Malin. "Rules of thumb and management of common infections in general practice /." Linköping : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-5183.

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Gavanescu, Irina Catrinel. "Autoantibodies to Centrosomes are Diagnostic for Human Scleroderma and Can Be Induced by Experimental Mycoplasma Infection in Mice: A Dissertation." eScholarship@UMMS, 2002. https://escholarship.umassmed.edu/gsbs_diss/76.

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The overall objective of this thesis work was to develop new insights into the etiology of scleroderma, a human systemic autoimmune disease, by analyzing the autoantibodies to centrosome antigens that develop during the disease. Centrosomes are perinuclear organelles that form microtubule arrays, including mitotic spindles that ensure the faithful segregation of chromosomes during mitosis. These studies used a novel methodology to determine the prevalence of anti-centrosome autoantibodies in patients with scleroderma. Recombinant centrosome antigens were used to determine the antigenic specifi
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38

Font, Vizcarra Lluís. "Utilitat dels cultius intraoperatoris en el diagnòstic etiològic i la detecció precoç de la infecció protètica." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/310785.

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Els cultius intraoperatoris són essencials pel diagnòstic bacteriològic i pel tractament de les infeccions protètiques. Malauradament, avui dia no existeix consens sobre quin tipus de mostres i quina quantitat d’elles s’ha de prendre. Tampoc existeix evidència de si l’ús sistemàtic dels cultius intraoperatoris durant la implantació d’una pròtesi ens permetria detectar de manera precoç aquelles amb un grau de contaminació suficient per acabar desenvolupant una infecció aguda. La present tesi doctoral avalua la utilitat dels cultius intraoperatoris en el diagnòstic etiològic i microbiol
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39

Al_griw, Huda Hm. "Molecular detection of bloodstream pathogens in critical illness." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/molecular-detection-of-bloodstream-pathogens-in-critical-illness(5f143a31-3694-454c-8940-5ae434f1eb31).html.

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Background: Critically ill patients are at particular risk of developing bloodstream infection. Such infections are associated with the development of sepsis, leading to a marked increase in mortality rate. Early detection of the causative organism and appropriate antibiotic treatment are therefore critical for optimum outcome of patients with nosocomial infection. Current infection diagnosis is based on standard blood culture techniques. However, microbiological culture has a number of limitations, not least that it takes several days to confirm infection and is therefore not useful in direct
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40

Padmanabhan, Babu roshan. "Taxano-genomics, a strategy incorporating genomic data into the taxonomic description of human bacteria." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5056.

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Mon projet de doctorat était de créer un pipeline pour taxono-génomique pour la comparaison de plusieurs génomes bactériens. Deuxièmement, je automatisé le processus d'assemblage (NGS) et annotation à l'aide de divers logiciels open source ainsi que la création de scripts de maison pour le laboratoire. Enfin, nous avons intégré le pipeline dans la description de plusieurs espèces bactériennes de laboratoire sur. Cette thèse est divisée principalement en Taxono- génomique et Microbiogenomics. Les avis de la section taxono-génomique, décrit sur les avancées technologiques en génomique et métagén
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41

Hamza, Abdou Azali. "Taxonomie et diagnostic des espèces de Xanthomonas associées à la gale bactérienne de la tomate et des Capsicum spp. : situation dans les Îles du Sud Ouest de l'océan Indien." Phd thesis, Université de la Réunion, 2010. http://tel.archives-ouvertes.fr/tel-00819814.

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La gale bactérienne des Solanées à graines est une maladie répandue dans la plupart des aires de production de tomate et des Capsicum spp. (piment, poivron) du monde. Elle est très sévère dans les régions tropicales et subtropicales et sa présence est récurrente dans la région Sud-Ouest de l'océan Indien. Cette maladie est complexe car cinq taxons sont actuellement reconnus comme agents causaux, X. vesicatoria , X. perforans , X. gardneri , X. euvesicatoria et X. campestris pv. raphani . Néanmoins certaines études récentes suggèrent des synonymies de certaines de ces espèces entre elles et éga
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42

Seng, Piseth. "Application de la spectrométrie de masse MALDI-TOF en microbiologie clinique." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5033/document.

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L'objectif de cette thèse est d'appliquer la méthode d'identification bactérienne par spectrométrie de masse MALDI-TOF pour une utilisation en routine dans un laboratoire de microbiologie clinique. Dans un 1er temps et de manière prospective, nous avons évalué la performance et le coût-efficacité de l'identification bactérienne de routine par MALDI-TOF par rapport aux techniques conventionnelles d'identification phénotypique. Durant la période des 16 semaines d'étude, nous avons comparé la performance de la technique par MALDI-TOF aux techniques conventionnelles d'identification phénotypique c
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43

Decuypere, S., Conor J. Meehan, Puyvelde S. Van, et al. "Diagnosis of Bacterial Bloodstream Infections: A 16S Metagenomics Approach." 2016. http://hdl.handle.net/10454/17303.

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Yes<br>Background. Bacterial bloodstream infection (bBSI) is one of the leading causes of death in critically ill patients and accurate diagnosis is therefore crucial. We here report a 16S metagenomics approach for diagnosing and understanding bBSI. Methodology/Principal Findings. The proof-of-concept was delivered in 75 children (median age 15 months) with severe febrile illness in Burkina Faso. Standard blood culture and malaria testing were conducted at the time of hospital admission. 16S metagenomics testing was done retrospectively and in duplicate on the blood of all patients. Total DNA
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Phillips, Aaron M. "Investigation of peptide nucleic acid fluorescence in situ hybridization for diagnosis of ventilator-associated pneumonia in bronchoalveolar lavage specimens." Thesis, 2014. http://hdl.handle.net/1805/3803.

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Dong, Zhi-Shun, and 董至舜. "Portable Fluorescent Detector for Multi-Target Bacterial Infection Diagnosis on a Paper-Based Device." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/bj4864.

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碩士<br>國立臺灣大學<br>應用力學研究所<br>107<br>In this study, we use graphene quantum dots (GQDs) and gold nanoclusters (AuNCs) for enzyme-linked immunosorbent assay (ELISA) detection of Staphylococcus aureus and Pseudomonas aeruginosa on a paper platform combined with a portable fluorescence detector to integrate multiplex fluorescence bacterial infection detection system. Fluorescent nanomaterials with different emission wavelengths were used in the paper-based ELISA as detection signals of two different bacteria. GQDs and AuNCs were used as the signal label for protein A (detection of Staphylococcus aur
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46

Holmes, Richard. "Towards a Novel Electrochemical Sensing Platform for Diagnosing Urinary Tract Infections." Thesis, 2012. http://hdl.handle.net/1807/33242.

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Urine culture, the current gold standard for urinary tract infection (UTI) diagnosis, does not produce results in an acceptable length of time. An ultra-sensitive, cost-effective electrochemical biosensing platform with nanostructured microelectrodes was designed to address the need for a rapid, point-of-care (PoC) test that could achieve a sample-to-answer time in less than an hour. Printed circuit boards and metallized glass slides were processed using various techniques and then tested for their ability to form nanostructured microelectrodes. Peptide nucleic acid probes for the bacteria and
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Rehling, Nico Sebastian. "Prävalenz bakterieller Infektionen bei psychiatrischen Erkrankungen – Zusammenhänge mit Alter, Verweildauer und F-Diagnosen." Doctoral thesis, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-132E-3.

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Lempens, P., Conor J. Meehan, K. Vandelannoote, et al. "Isoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations." 2018. http://hdl.handle.net/10454/17278.

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Yes<br>The majority of Mycobacterium tuberculosis isolates resistant to isoniazid harbour a mutation in katG. Since these mutations cause a wide range of minimum inhibitory concentrations (MICs), largely below the serum level reached with higher dosing (15 mg/L upon 15–20 mg/kg), the drug might still remain partly active in presence of a katG mutation. We therefore investigated which genetic mutations predict the level of phenotypic isoniazid resistance in clinical M. tuberculosis isolates. To this end, the association between known and unknown isoniazid resistance-conferring mutations in whol
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May, Fiona J. "Epidemiology of foodborne and emerging infectious diseases in Australia, 2014 to 2015." Phd thesis, 2015. http://hdl.handle.net/1885/109815.

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My placement was with the Zoonoses, Foodborne and Emerging Infectious Diseases section in the Office of Health Protection at the Australian Government Department of Health during 2014-2015. I focused on the following five projects. I described the epidemiology of bacterial toxin mediated foodborne outbreaks in Australia and identified risk factors and risk groups, from an analysis of outbreak data recorded from 2001 to 2013. The main risk factor for bacterial toxin mediated foodborne outbreaks is temperature abuse (storage between 4C and 60 C)
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Meehan, Conor J., G. A. Goig, T. A. Kohl, et al. "Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues." 2019. http://hdl.handle.net/10454/17276.

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No<br>Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed from a research tool to a clinical application for the diagnosis and management of tuberculosis and in public health surveillance. This development has been facilitated by drastic drops in cost, advances in technology and concerted efforts to translate sequencing data into actionable information. There is, however, a risk that, in the absence of a consensus and international standards, the widespread use of WGS technology may result in data and processes that lack harmonization, comparability and validatio
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