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Dissertations / Theses on the topic 'Beta-lactam antibiotic'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Sayer, P. "The synthesis of #beta#-lactam antibiotic analogues." Thesis, Lancaster University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235587.

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2

Rogers, M. E. "Beta-lactam antibiotics : Analysis and biosynthesis." Thesis, University of Westminster, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383031.

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3

King, Dustin T. "Protecting our beta-lactam antibiotic assets : structural investigation of beta-lactamases." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/56341.

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Bacterial diseases have an enormous impact on human health. The most widespread class of human antibacterials is the β-lactams that target the transpeptidase activity of penicillin-binding proteins, which are responsible for cross-linking the peptidoglycan cell-wall. However, bacteria have gained resistance to all major classes of β-lactams. To protect the clinical utility of the β-lactams it is essential to understand the structural basis for this resistance. This thesis aims to better understand the molecular details governing extended-spectrum β-lactamase mediated β-lactam resistance, and t

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4

Vasilenko, Sofia, and Софія Василенко. "Bacteria resistance to beta-lactam antibiotics." Thesis, National Aviation University, 2021. https://er.nau.edu.ua/handle/NAU/50637.

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1. Pulok K. Mukherjee. Quality Control and Evaluation of Herbal Drugs: Evaluating Natural Products and Traditional Medicine. Elsevier, 2019. 762 p. 2. Kumar A., Schweizer H. Bacterial resistance to antibiotics: Active efflux and reduced uptake. Adv. Drug Deliv. Rev. 2005. Vol. 57. P. 513. 3. Antimicrobial Resistance: Tackling a Crisis for the Future Health and Wealth of Nations. Chaired by Jim O’Neill. London: Review on Antimicrobial Resistance. 2014. 16 p. 4. Thomas C. M., Nielsen K.M. Mechanisms of, and barriers to, horizontal gene transfer between bacteria. Nat. Rev. Microbiol. 2005. Vol. 3

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5

Bening, Sarah Christine. "Exploring and enhancing context-dependent beta-lactam antibiotic efficacy." Thesis, Massachusetts Institute of Technology, 2021. https://hdl.handle.net/1721.1/130805.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, February, 2021<br>Cataloged from the official PDF version of thesis.<br>Includes bibliographical references (pages 77-89).<br>Antibiotics, such as beta-lactams, are essential medical tools for the treatment of bacterial infections. Unfortunately, clinical treatment efficacy is declining over time as bacteria adapt to and evade antibiotic treatment through mechanisms called antibiotic resistance, tolerance, and persistence. Antibiotic tolerance and persistence, in particular, are often context-dependent

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6

Wallace, Jeremy Iain. "Hyperinducible Î²-lactamase expression in gram-negative bacteria." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295568.

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7

Turner, Philip J. "The in-vitro sensitivity testing of beta-lactam antibiotic combinations." Thesis, Aston University, 1985. http://publications.aston.ac.uk/12477/.

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8

Korir, Cindy Chepngeno. "Biochemical and molecular characterization of streptococcus pneumoniae strains resistant to beta-lactam antibiotics." Diss., Available online, Georgia Institute of Technology, 2004:, 2004. http://etd.gatech.edu/theses/available/etd-07062004-081519/unrestricted/korir%5Fcindy%5Fc%5F200407%5Fphd.pdf.

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Thesis (Ph. D.)--School of Biology, Georgia Institute of Technology, 2005. Directed by Paul Edmonds.<br>Paul Edmonds, Committee Chair ; Steve Harvey, Committee Member ; Igor Zhulin, Committee Member ; Yury Chernoff, Committee Member ; Mostafa El-Sayed, Committee Member. Includes bibliographical references.

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9

Saunders, Geoffrey Lance. "Beta-lactam antibiotic resistance in enterobacter cloacae isolated from Groot Schuur Hospital inpatients." Thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/25559.

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10

Saunders, G. L. (Geoffrey Lance). "Beta-lactam antibiotic resistance in enterobacter cloacae isolated from Groot Schuur Hospital inpatients." Master's thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/25557.

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11

Wilke, Mark Steven. "Structural characterization of superbug proteins involved in regulating beta-lactam resistance." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/725.

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The widespread use of β-lactams has undermined their effectiveness as chemotherapeutic agents by fueling the evolution and dissemination of multiple resistance mechanisms, including: (1) production of hydrolytic β-lactamase enzymes that inactivate β-lactams, (2) expression of PBPs with low-affinity for β-lactams and (3) overexpression of multidrug efflux pumps which actively expunge β-lactams and other toxic substances. The overall goal of this thesis is the structural characterization of bacterial proteins involved in regulating β-lactam resistance. The notorious resistance of Staphy

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12

Gross, Viktoriia. "An integrative approach to characterize and predict cell death and escape to beta-lactam antibiotic treatments." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASB035.

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La résistance aux antibiotique est de plus en plus courante. En particulier, la fraction croissante d'Escherichia coli commensaux et pathogènes exprimant des bêta-lactamases à spectre étendu et/ou des carbapénémases est alarmante. E. coli est une cause majeure d'infections courantes telles que les infections urinaires, qui touchent plus de 150 millions de personnes dans le monde. Il est important de noter que de nombreuses infections récidivent. Il est donc essentiel de comprendre en profondeur la sensibilité des isolats cliniques d'E. coli aux bêta-lactamines pour proposer des traitements eff

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13

Orford, Colin David. "The enzymes and intermediates involved in the early stages of #beta#-lactam antibiotic biosynthesis in Penicillium chrysogenum." Thesis, University of Westminster, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252655.

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14

Prosen, Katherine Rose. "Investigating the Mode of Action of a Novel N-sec-butylthiolated Beta-lactam Against Staphylococcus aureus." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3609.

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N-sec -butylthioloated β-lactam (NsβL) is a novel beta-lactam antimicrobial with a mechanism of action proposed to inhibit 3-oxoacyl-acyl carrier protein synthase (ACP) III (FabH), resulting in the inhibition of fatty acid synthesis. It has been suggested that NsβL inhibits FabH indirectly by inactivating coenzyme-A (CoA). CoA is an essential cofactor for numerous proteins involved in glycolysis, the citric acid cycle (TCA), and pyruvate metabolism, in addition to fatty acid biosynthesis. This study aimed to determine the effects of NsβL on a diverse array of laboratory and clinical Staphyloc

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15

Nichols, Derek Allen. "Structure-Based Design of Novel Inhibitors and Ultra High Resolution Analysis of CTX-M Beta-Lactamase." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5284.

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The emergence of CTX-M class-A extended-spectrum β-lactamases, which confer resistance to second and third-generation cephalosporins, poses a serious health threat to the public. CTX-M β-lactamases use a catalytic serine to hydrolyze the β-lactam ring. Specifically, the hydrolysis reaction catalyzed by CTX-M β-lactamase proceeds through a pre-covalent complex, a high-energy tetrahedral acylation intermediate, a low-energy acyl-enzyme complex, a high-energy tetrahedral deacylation intermediate after attack via a catalytic water, and lastly, the hydrolyzed β-lactam ring product which is released

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16

Bibbal, Delphine. "Impact des bêta-lactamines sur l'émergence d'entérobactéries résistantes dans la flore digestive chez le porc : caractérisation et stratégie de prévention." Toulouse 3, 2008. http://thesesups.ups-tlse.fr/535/.

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L'antibiothérapie chez les animaux contribue à la sélection de résistances bactériennes au niveau du tube digestif, potentiellement transmissibles à l'homme. La caractérisation phénotypique et génotypique de l'émergence d'entérobactéries digestives résistantes, lors de pression de sélection par une bêta-lactamine, a été réalisée chez le porc. Des souches d'E. Coli majoritairement multirésistantes ont été sélectionnées et l'analyse des pulsotypes des ces souches suggère une sélection de clones déjà présents mais minoritaires dans le tube digestif. Une stratégie thérapeutique visant à prévenir l

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17

Malott, Bradley. "Development and investigation of antibiotic resistance in E. coli using aminoglycosides." Wittenberg University Honors Theses / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wuhonors1617617698561944.

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18

Araújo, Bibiana Verlindo de. "Modelagem farmacocinética-farmacodinâmica da piperacilina em ratos imunodeprimidos infectados com Escherichia coli." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2002. http://hdl.handle.net/10183/14773.

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Objetivos: Avaliar a adequabilidade do modelo farmacocinético-farmacodinâmico (PK-PD) (NOLTING et al., 1996b) para modelar o efeito bactericida da piperacilina (PIP) em ratos Wistar infectados experimentalmente com Escherichia coli ATCC 25922. Metodologia: Experimentos de Farmacocinética: Determinou-se as concentrações plasmáticas totais e livres teciduais de PIP, através de microdiálise (MD), após administração de 240 mg/kg i.v. bolus a ratos Wistar granulocitopênicos (ciclofosfamida) infectados no músculo esquelético (105 UFC/mL) com E. coli. As amostras de plasma e de MD foram analisadas po

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19

Philippe, Jules. "Pneumococcus morphogenesis and resistance to beta-lactams." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENV018/document.

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Streptococcus pneumoniae, le pneumocoque, est une bactérie pathogène qui entraîne le décès de plus d'un million et demi de personnes dans le monde chaque année. Les β-lactamines sont très utilisées pour traiter les infections à pneumocoques. Ces antibiotiques inhibent la synthèse du peptidoglycane, une molécule géante constituant un réseau de chaînes glycopeptidiques qui englobe la cellule, lui confère sa forme et lui permet de maintenir son intégrité face à la pression osmotique. Le mécanisme d'action des β-lactamines est bien connud'un point de vue biochimique. En revanche, la réponse physio

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20

Cuthbert, B. K. "Analogues of beta-lactam antibiotics." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370245.

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21

Lejon, Sara. "Evasion and Attack: Structural Studies of a Bacterial Albumin-binding Protein and of a Cephalosporin Biosynthetic Enzyme." Doctoral thesis, Uppsala : University Library Universitetsbiblioteket, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8399.

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22

Hadfield, Peter Stanley. "The synthesis of #gamma#-lactam mimics of #beta#-lactam antibiotics." Thesis, University of Huddersfield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338614.

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23

Jayaweera, G. D. S. A. "Some aspects of beta-lactam chemistry." Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370619.

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24

Hedberg, Maria. "[Beta]-lactam resistance in anaerobic bacteria." Stockholm : Division of Oral Microbiology, Dept. of Immunology, Microbiology, Pathology and Infectious Diseases, Hudding University Hospital, Karolinska Institute, 1995. http://catalog.hathitrust.org/api/volumes/oclc/33394040.html.

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25

Schofield, C. "Chemical and enzymatic synthesis of beta-lactam antibiotics." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355775.

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26

Freeman, Richard Neil Templar. "The total synthesis of non-beta-lactam antibiotics." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257963.

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27

Blackburn, Jonathan Michael. "Investigation into the biosynthesis of #beta#-lactam antibiotics." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303654.

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28

Bolister, Nina Jane. "The diffusion of beta-lactam antibiotics through biopolymers." Thesis, University of Brighton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328209.

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29

Harris, T. A. J. "The ion-pair extraction of beta-lactam antibiotics." Thesis, London South Bank University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279405.

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30

Badin, Sevil. "Genetic epidemiology of allergy to beta-lactam antibiotics." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/genetic-epidemiology-of-allergy-to-betalactam-antibiotics(c6571b05-3322-4662-88c4-88b300c96c9d).html.

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Background: Immediate antibiotic allergic response is an important public health problem. Genetic and molecular characterization will improve treatment outcomes for truly allergic patients, and also reduce the use (and risk of evolution of pathogen resistance) of second-line antibiotics given to patients who incorrectly believe themselves to be allergic to first-line antibiotics. Objective: To identify genetic and metabolic factors associated with allergic responses to beta-lactam antibiotics using the TwinsUK cohort and recruited participants from the Guy’s allergy clinic. Methods: The TwinsU

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31

Eley, A. R. "The response of Bacteroides species to beta-lactam antibiotics." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356555.

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32

Cox, G. "Synthesis of carbocyclic analogues of the #beta#-lactam antibiotics." Thesis, University of Huddersfield, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374894.

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33

Payne, David John. "Novel aspects of transferable resistance to beta-lactam antibiotics." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/19226.

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Until 1983, third generation cephalosporins (3GC) were thought to be resistant to hydrolysis by all plasmid-mediated β-lactamases. However, TEM and SHV derived β-lactamases have recently evolved which can confer transferable resistance to 3GC. Six novel plasmid β-lactamases, which confer transferable resistance to 3GC have been identified and characterised. They have been compared directly to the other 3GC hydrolysing β-lactamases discovered elsewhere. The criteria implemented to distinguish these different β-lactamases were: Km and Vmax values for the hydrolysis of different substrates, molec

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34

Reid, Alison Jean. "Resistance to beta-lactam antibiotics in gram-negative bacteria." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/19258.

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35

Cacciatore, Giuseppe. "Screening auf Rückstände von [beta]-Lactam-Antibiotika [Beta-Lactam-Antibiotika] in Milch: Entwicklung eines optischen Biosensor-Assays mit Penicillin-bindenden Proteinen." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974861820.

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36

Rowe, Christine Janet. "Genetic engineering of penicillin biosynthesis." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307008.

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37

Buckwell, S. C. "The kinetics of the #beta#-lactamase catalysed hydrolysis of cephalosporins." Thesis, University of Huddersfield, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376437.

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38

Tarr, Shahida. "Using gene shuffling to increase genetic diversity in genes involved in beta-lactam biosynthesis." Thesis, Rhodes University, 2001. http://hdl.handle.net/10962/d1004074.

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The actinomycetes are gram-positive bacteria that produce more than two-thirds of the known biologically active microbial natural products, including many commercially important antibiotics, anti-cancer agents, other pharmacologically useful agents, animal health products and agrochemicals. The prevailing utilization of antibiotics continues to be the mainstay against microbial infections and a majority ofthe over six thousand antibiotics discovered thus far are from Streptomyces spp. One of the most well-characterized antibiotic biosynthetic pathway is the one involving the biosynthesis of th

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39

Thorburn, Christine Elaine. "The effect of pharmacokinetics on the development of bacterial resistance to antibiotics." Thesis, University of East London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359992.

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40

Davis, Simon Christopher. "Studies on the cleavage of sidechains from #beta#-lactam antibiotics." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315699.

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41

Bird, Juliette W. "Biosynthetic studies on the tripeptide precursor of #beta#-lactam antibiotics." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253002.

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42

Knight, J. "New synthetic methods for the synthesis of #BETA#-lactam antibiotics." Thesis, University of Southampton, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373921.

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43

McGillivary, Angela. "Reactive solvent extraction of #beta#-lactam antibiotics and other anions." Thesis, London South Bank University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326763.

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44

Frampton, Helen Kathleen. "Studies of resistance to Beta-lactam antibiotics in Bacillus licheniformis." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328977.

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45

Sakhnini, Nina Issam. "The synthesis of novel compounds related to #beta#-lactam antibiotics." Thesis, University of Sussex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359204.

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46

Shah, Ajit Jesang. "The analysis of #beta#-lactams and their biosynthetic intermediates in fermentations of #beta#-lactam producing fungi." Thesis, University of Westminster, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358855.

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47

Crompton, I. A. "Studies on #beta#-lactamases." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233406.

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48

Goh, Kee Chuan. "The biosynthesis of β-lactams". Thesis, University of Oxford, 1993. http://ora.ox.ac.uk/objects/uuid:24b6b29d-87cc-48f2-bd1b-bb64c663604f.

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This thesis reports the work done on two research projects which were carried out independently of each other but converge on the central theme of β-lactam biosynthesis. Chapter 1 provides an overview of biosynthesis in secondary metabolism, with special emphasis on current knowledge about the β-lactams. The first project, covered from Chapters 2 to 5, was part of our group's continuing effort to understand the structure and mechanism of Ring Expandase-Hydroxylase (REXH), an enzyme involved in the biosynthesis of cephalosporin C in Cephalosporium acremonium. REXH is a bifunctional enzyme, conv

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49

Leung, Yun-Chung. "Properties of mutatant derivatives of #beta#-lactamase I from Bacillus cereus." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260180.

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50

Gustavsson, Eva. "SPR biosensor analysis of [beta]-lactam antibiotics in milk : devoplement and use of assays based on a [beta]-lactam receptor protein /." Uppsala : Swedish Univ. of Agricultural Sciences, 2003. http://www.gbv.de/dms/bs/toc/363528245.pdf.

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