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Journal articles on the topic 'Beta-lactam antibiotic'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Bradley, Nicole, Yuman Lee, and Dana Weinstein. "Overview of Beta-Lactam Allergy and the Role of the Pharmacist in Management." Allergies 1, no. 2 (2021): 128–36. http://dx.doi.org/10.3390/allergies1020011.

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Unverified beta-lactam allergies are a substantial public health problem, as the majority of patients labeled as beta-lactam allergic do not have clinically significant allergies that may hinder the use beta-lactam therapy when indicated. Outdated or inaccurate beta-lactam or penicillin allergies can result in serious consequences, including suboptimal antibiotic therapy, increased risk of adverse effects, and use of broader spectrum antibiotics than indicated, which may contribute to antimicrobial resistance. The purpose of this review is to provide an overview of beta-lactam allergy and high

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Asham, Preet Saini1 Shivam Sharma2 Tarun Sharma3 Kailash Singh Bisht*4. "Evaluation And Management Strategies for Beta-Lactam Antibiotics Induced Hypersensitivity Reactions: A Comprehensive Review." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 3188–206. https://doi.org/10.5281/zenodo.15110977.

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Beta-lactam antibiotics are essential and extensively utilized medications for bacterial infections in clinical settings. Penicillin has the highest prevalence of inducing hypersensitivity reactions among beta-lactam antibiotics. This can lead to poor treatment outcomes, increased risk for antibiotic resistance, and high treatment expenses. With an increasing number of suspected cases of hypersensitivity reactions, it is essential to accurately diagnose them using sensitive skin testing and in-vitro methods, while minimizing the risk of serious adverse reactions. A thorough evaluation could ef

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Wieringa, André, Tim M. J. Ewoldt, Ravish N. Gangapersad, et al. "Predicting Beta-Lactam Target Non-Attainment in ICU Patients at Treatment Initiation: Development and External Validation of Three Novel (Machine Learning) Models." Antibiotics 12, no. 12 (2023): 1674. http://dx.doi.org/10.3390/antibiotics12121674.

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In the intensive care unit (ICU), infection-related mortality is high. Although adequate antibiotic treatment is essential in infections, beta-lactam target non-attainment occurs in up to 45% of ICU patients, which is associated with a lower likelihood of clinical success. To optimize antibiotic treatment, we aimed to develop beta-lactam target non-attainment prediction models in ICU patients. Patients from two multicenter studies were included, with intravenous intermittent beta-lactam antibiotics administered and blood samples drawn within 12–36 h after antibiotic initiation. Beta-lactam tar

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Dhaese, Sofie A. M., Eric A. Hoste, and Jan J. De Waele. "Why We May Need Higher Doses of Beta-Lactam Antibiotics: Introducing the ‘Maximum Tolerable Dose’." Antibiotics 11, no. 7 (2022): 889. http://dx.doi.org/10.3390/antibiotics11070889.

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The surge in antimicrobial resistance and the limited availability of new antimicrobial drugs has fueled the interest in optimizing antibiotic dosing. An ideal dosing regimen leads to maximal bacterial cell kill, whilst minimizing the risk of toxicity or antimicrobial resistance. For beta-lactam antibiotics specifically, PK/PD-based considerations have led to the widespread adoption of prolonged infusion. The rationale behind prolonged infusion is increasing the percentage of time the beta-lactam antibiotic concentration remains above the minimal inhibitory concentration (%fT>MIC). The ulti

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Ji, Youqi, Yinhuan Wang, Zhangkai Xu та ін. "Small Molecules from Medicinal Plant Iris tectorum as Histidine Kinase Inhibitor to Resensitize β-Lactam-Resistant Escherichia coli". Molecules 30, № 3 (2025): 663. https://doi.org/10.3390/molecules30030663.

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Background: Due to the widespread use of broad-spectrum antibiotics, the problem of antibiotic resistance has become an increasingly serious global threat. One of the key mechanisms of Escherichia coli resistance to beta-lactam antibiotics is the production of beta-lactamase enzymes, which poses a dilemma for clinicians in selecting antibiotics when faced with resistant bacterial infections. However, research on the reversal of bacterial resistance is limited. Methods: This study involved the preparation of Iris tectorum extract and detection of its effects on antibiotics sensitivity, extended

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Gozali, Cynthia, and Conny Riana Tjampakasari. "Pseudomonas aeruginosa biofilm formation and its resistance to beta-lactam antibiotics." Damianus Journal of Medicine 22, no. 2 (2023): 162–72. http://dx.doi.org/10.25170/djm.v22i2.3928.

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ABSTRACT Introduction: An opportunistic pathogen, Pseudomonas aeruginosa is a Gram-negative bacteria that causes acute and chronic human infections. By adhering to appropriate surfaces and creating a biofilm matrix, Pseudomonas aeruginosa has a high-resistance structure. Due to biofilm resistance mechanisms, this bacterial biofilm may increase natural antibiotic resistance. Antibiotics have difficulty penetrating the exopolysaccharide matrix that makes up the biofilm structure (Psl, Pe, alginate, and eDNA). Alginate is involved in generating mucus, and Psl and Pel components are implicated in

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Legg, Amy, Sinead Carmichael, Ming G. Chai, Jason A. Roberts, and Menino O. Cotta. "Beta-Lactam Dose Optimisation in the Intensive Care Unit: Targets, Therapeutic Drug Monitoring and Toxicity." Antibiotics 12, no. 5 (2023): 870. http://dx.doi.org/10.3390/antibiotics12050870.

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Beta-lactams are an important family of antibiotics used to treat infections and are commonly used in critically ill patients. Optimal use of these drugs in the intensive care unit (ICU) is important because of the serious complications from sepsis. Target beta-lactam antibiotic exposures may be chosen using fundamental principles of beta-lactam activity derived from pre-clinical and clinical studies, although the debate regarding optimal beta-lactam exposure targets is ongoing. Attainment of target exposures in the ICU requires overcoming significant pharmacokinetic (PK) and pharmacodynamic (

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Krey, Steven C., Jeff Waise, and Lee P. Skrupky. "Confronting the Challenge of Beta-Lactam Allergies: A Quasi-Experimental Study Assessing Impact of Pharmacy-Led Interventions." Journal of Pharmacy Practice 32, no. 2 (2017): 139–46. http://dx.doi.org/10.1177/0897190017743154.

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Objective: To improve allergy history documentation and increase the use of beta-lactams when appropriate in patients with a reported beta-lactam allergy. Methods: This pre–post study was conducted at a 167-bed tertiary care community hospital and evaluated multidisciplinary interventions on allergy documentation and antibiotic selection. Interventions included education, creation of local practice guidelines, and modified practices for pharmacists and pharmacy technicians. Inpatients with a reported beta-lactam allergy receiving at least 1 antibiotic for >24 hours were included; first admi

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Abd, Luma Salman. "Historical Review of the Penicillin and Related Compounds (β – Lactams)". Al Mustansiriyah Journal of Pharmaceutical Sciences 18, № 1 (2018): 109–27. http://dx.doi.org/10.32947/ajps.v18i1.464.

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In spite of the old age of beta lactam, they continue to provide good health and preventing human diseases by virtue of industrial production and discoveries of small new beta-lactam group of secondary metabolite. Antibiotic resistance in bacteria has become a serious problem worldwide therefore, the present survey discusses the event that occurred in the progress of the penicillin, and beta-lactam from discovery to implementation as a therapeutic agent in order to overcome this issue . Moreover, this review provides a descriptive overview of the various published ways to enhance the clinical

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Semizhon, P. A., H. P. Scheslenok, I. V. Harbachova, I. I. Vashkevich, and O. V. Sviridov. "MONITORING OF BIOLOGICAL ACTIVITY OF BETA-LACTAM ANTIBIOTICS RECEPTOR BLAR-CTD IN THE PROCESSES OF ITS HETEROLOGICAL EXPRESSION, PURIFICATION AND APPLICATION IN ANALYTICAL SYSTEMS." http://eng.biomos.ru/conference/articles.htm 1, no. 19 (2021): 246–48. http://dx.doi.org/10.37747/2312-640x-2021-19-246-248.

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To develop the technologies of beta-lactam antibiotics bioassays in foods, high purity beta-lactam receptor BlaR-CTD has been obtained and characterized. A test system for the quantitation of the biologically active and immunoreactive receptor in the processes of its heterological expression, isolation and reagent forms preparation was elaborated. The immunochemical properties and antibiotic binding ability of BlaR-CTD were investigated, and the constructions and application procedures of receptor-immune systems for the assay of beta-lactam antibiotics using microplates or chromatographic test

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Ahsan, Sunjukta, Anindita Bhowmik, Sharmistha Goswami, and Nasir Uddin. "Detection of New Delhi Metallo b Lactamase gene in Uropathogenic E. coli." Bangladesh Journal of Microbiology 36, no. 1 (2019): 29–33. http://dx.doi.org/10.3329/bjm.v36i1.44280.

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The rapid dissemination of antibiotic resistant E. coli is now a worldwide problem. In this study, a total of twenty E. coli obtained from stool were selected to determine resistance to beta lactam antibiotics. Beta–Lactamase are enzymes produced by bacteria that provide multi resistance to beta lactam antibiotics such as penicillin, cephalosporin, cephamycin and carbapenems. Of these isolates (n = 20), 35% were found resistant to Amoxicillin Clavulanate, 5% to Imipenem, 50% to Ceftriaxone and 75% to Ampicillin. PCR amplification confirmed the presence of the New Delhi beta-lactamase gene (bla

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12

Leanza, Gabriele Maria, Beatrice Liguoro, Simone Giuliano, et al. "The Subcutaneous Administration of Beta-Lactams: A Case Report and Literary Review—To Do Small Things in a Great Way." Infectious Disease Reports 16, no. 1 (2024): 93–104. http://dx.doi.org/10.3390/idr16010007.

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The subcutaneous (s.c.) route is a commonly used method for delivering various drugs, although its application in the administration of antibiotics is relatively uncommon. In this case, we report a successful treatment of nosocomial pneumonia using piperacillin/tazobactam via continuous subcutaneous administration. Furthermore, this article provides an overview of the current literature regarding the s.c. administration of beta-lactam antibiotics. Based on our analysis, we identified only 15 studies that described the s.c. use of beta-lactam antibiotics in human subjects. Among these studies,

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Leibovici, L., M. Paul, O. Poznanski, et al. "Monotherapy versus beta-lactam-aminoglycoside combination treatment for gram-negative bacteremia: a prospective, observational study." Antimicrobial Agents and Chemotherapy 41, no. 5 (1997): 1127–33. http://dx.doi.org/10.1128/aac.41.5.1127.

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The aim of the present study was to test whether the combination of a beta-lactam drug plus an aminoglycoside has advantage over monotherapy for severe gram-negative infections. Of 2,124 patients with gram-negative bacteremia surveyed prospectively, 670 were given inappropriate empirical antibiotic treatment and the mortality rate in this group was 34%, whereas the mortality rate was 18% for 1,454 patients given appropriate empirical antibiotic treatment (P = 0.0001). The mortality rates for patients given appropriate empirical antibiotic treatment were 17% for 789 patients given a single beta

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Stašek, Jan, Filip Keller, Veronika Kočí, et al. "Update on Therapeutic Drug Monitoring of Beta-Lactam Antibiotics in Critically Ill Patients—A Narrative Review." Antibiotics 12, no. 3 (2023): 568. http://dx.doi.org/10.3390/antibiotics12030568.

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Beta-lactam antibiotics remain one of the most preferred groups of antibiotics in critical care due to their excellent safety profiles and their activity against a wide spectrum of pathogens. The cornerstone of appropriate therapy with beta-lactams is to achieve an adequate plasmatic concentration of a given antibiotic, which is derived primarily from the minimum inhibitory concentration (MIC) of the specific pathogen. In a critically ill patient, the plasmatic levels of drugs could be affected by many significant changes in the patient’s physiology, such as hypoalbuminemia, endothelial dysfun

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Asada, K., Y. Inaba, E. Tateda-Suzuki, K. Kuwahara-Arai, T. Ito, and K. Hiramatsu. "Evolution and resistance expression of MRSA. Evaluation of beta-lactam antibiotics against a set of isogenic strains with different types of phenotypic expression." Acta Biochimica Polonica 42, no. 4 (1995): 517–24. http://dx.doi.org/10.18388/abp.1995_4905.

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Methicillin-resistant Staphylococcus aureus (MRSA) has two mechanisms of resistance to beta-lactam antibiotics; one is mediated by mecA gene expression, and the other by penicillinase production. It has been generally accepted in the clinical field that beta-lactam antibiotics are not the drugs of choice for MRSA infection. In this report, however, ampicillin and penicillin G were shown to have relatively good activity against MRSA if combined with a beta-lactamase inhibitor, sulbactam. These beta-lactam antibiotics were found to have relatively high binding affinities to PBP2', the mecA-encod

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Ghiska Ma’alia Yusuf and Musa Fitri Fatkhiya. "Pengetahuan Pasien Terhadap Adverse Drug Reactions (ADRs) Penggunaan Obat Antibiotik Beta-Laktam di RSUD Bendan Tahun 2024." OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan 3, no. 3 (2025): 135–44. https://doi.org/10.61132/obat.v3i3.1295.

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Knowledge is the result of the process of understanding and recognizing something obtained through sensing an object. Beta-lactam antibiotics are a type of broad-spectrum antibiotic commonly used to treat bacterial infections, but their use still has the potential to cause side effects in the form of Adverse Drug Reactions (ADRs). This study aims to assess the level of patient knowledge regarding ADRs due to the use of beta-lactam antibiotics at Bendan Pekalongan Regional Hospital in 2024. This study used a prospective correlation design with a non-experimental approach. A total of 29 outpatie

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Sandoe, Jonathan A. T., Kordo Saeed, Achyut Guleri, et al. "Opportunities for antimicrobial stewardship in patients with acute bacterial skin and skin structure infections who are unsuitable for beta-lactam antibiotics: a multicenter prospective observational study." Therapeutic Advances in Infectious Disease 6 (January 2019): 204993611882365. http://dx.doi.org/10.1177/2049936118823655.

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Purpose: The objective of this prospective, observational study was to describe the treatment, severity assessment and healthcare resources required for management of patients with acute bacterial skin and skin structure infections who were unsuitable for beta-lactam antibiotic treatments. Methods: Patients were enrolled across five secondary care National Health Service hospitals. Eligible patients had a diagnosis of acute bacterial skin and skin structure infection and were considered unsuitable for beta-lactam antibiotics (e.g. confirmed/suspected methicillin-resistant Staphylococcus aureus

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D Denge, Abhishek, Yasaswi Vanga, and Rashmi Singh. "Precision Timing of Beta-Lactam Administration in Very Low Birth Weight Infants with Suspected Sepsis: A Multi-National Cohort Study." Journal of Neonatal Surgery 14, no. 4S (2025): 919–31. https://doi.org/10.52783/jns.v14.1897.

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Background: Timely administration of antibiotics is critical in the management of sepsis, but evidence regarding optimal timing of beta-lactam administration in very low birth weight (VLBW) infants remains limited. This study investigated the association between precision timing of beta-lactam administration and clinical outcomes in VLBW infants with suspected sepsis. Methods: We conducted a retrospective multi-national cohort study across 4 neonatal intensive care units in 4 countries from January 2021 to December 2023. VLBW infants (birth weight <1500 g) with clinically suspected sepsis w

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Vega Harwood, Alicia Wendy, Marta Martín Fernández, Carlos Ezquer Garin, et al. "Antimicrobial Dosing During Continuous Venovenous Hemodiafiltration in Septic Shock Patients: A Prospective, Multicenter Study Protocol." Antibiotics 14, no. 4 (2025): 420. https://doi.org/10.3390/antibiotics14040420.

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Background: Sepsis is a major global health issue and the leading cause of death in critically ill patients, with rising incidence and associated healthcare costs. Early administration of antibiotic therapy is crucial, but increasing antibiotic resistance poses a threat. Beta-lactam antibiotics, commonly used as a first-line therapy option against sepsis, often demonstrate unpredictable concentrations due to pharmacokinetic and pharmacodynamic changes in critically ill patients. Acute kidney injury (AKI) affects a significant portion of septic patients, and continuous renal replacement therapy

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Mukhsinov, Farkhod Munisovich, and Irina Vladimirovna Liverko. "PHENOTYPIC PREDICTORS AND BIOMARKERS FOR FORECASTING THE EFFECTIVENESS OF ANTIMICROBIAL THERAPY." journal of cardiorespiratory research 3, no. 3 (2022): 3. https://doi.org/10.5281/zenodo.7145906.

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According to the results, it was found that the serum beta-lactamase activity level is determined by phenotypic and clinical variables: age over 60 years, severe respiratory pathology, fever over 380 , peripheral blood leukocyte level over 10x109, C-reactive protein over 40 mg/L and saturation less than 93%, correlating with an increase in UAV levels, and are predictors of low efficacy of treatment with beta-lactam antibiotics. A direct correlation was revealed between the level of serum beta-lactamase activity and the duration of antimicrobial therapy during the year (r=+0.86, p=0.001), the n

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Syromyatnikov, M. Yu, S. V. Shabunin, E. Yu Nesterova, et al. "ANALYSIS OF ANTIBIOTIC RESISTANCE GENES OF ESCHERICHIA COLI FROM THE GUT OF THE PIGLETS WITH DIARRHEA." Transactions of the educational establishment “Vitebsk the Order of “the Badge of Honor” State Academy of Veterinary Medicine 60, no. 2 (2024): 95–100. http://dx.doi.org/10.52368/2078-0109-2024-60-2-95-100.

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The study is devoted to the analysis of the prevalence of antibiotic resistance genes in cultures of E. coli isolated from the gut of the piglets with diarrhea. With the use of high-throughput sequencing, it was possible to identify 26 antibiotic resistance genes. They belonged to 7 groups of antibiotics: aminoglycosides, beta-lactam antibiotics, quinolones, sulfonamides, tetracyclines, diaminopyrimidine, phenicols. The relative abundance of the QnrD gene was maximal in the studied sample of E. coli isolates (50%). For other sequences of antibiotic resistance genes, the percentage ratio of eac

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Connelly, Sheila, Todd Parsley, Hui Ge, and Michael Kaleko. "Identification, Characterization, and Formulation of a Novel Carbapenemase Intended to Prevent Antibiotic-Mediated Gut Dysbiosis." Microorganisms 7, no. 1 (2019): 22. http://dx.doi.org/10.3390/microorganisms7010022.

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Antibiotics can damage the gut microbiome leading to opportunistic infections and the emergence of antibiotic resistance. Microbiome protection via antibiotic inactivation in the gastrointestinal (GI) tract represents a strategy to limit antibiotic exposure of the colonic microbiota. Proof of concept for this approach was achieved with an orally-administered beta-lactamase enzyme, SYN-004 (ribaxamase), that was demonstrated to degrade ceftriaxone excreted into the GI tract and protect the gut microbiome from antibiotic-mediated dysbiosis. Ribaxamase efficiently degrades penicillin and cephalos

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Kryukova, D., A. Sokolov, and Maksim Maksimov. "Pharmacology of inhibitor-protected beta-lactam agents." Novejshie zarubezhnye i otechestvennye lekarstvennye preparaty: farmakoterapija, farmakodinamika, farmakokinetika (Newest Foreign and Domestic Preparations: Pharmacotherapy, Pharmacodynamics, Pharmacokinetics), no. 3 (June 1, 2020): 53–69. http://dx.doi.org/10.33920/med-06-2003-05.

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Beta-lactam antibiotics are the most widely used class of antibacterial drugs, both for outpatient and hospital infections. Their further improvement in relation to overcoming the resistance of microorganisms to this group of antibiotics has given new opportunities in the treatment of severe infectious diseases. Due to the obtained high efficiency of β-lactam antibiotics and their low toxicity, they form the basis of antimicrobial chemotherapy at present. Antibiotic resistance is the phenomenon of resistance of a stain of infectious agents to the action of one or more antibacterial drugs. It i

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Kale-Pradhan, Pramodini, Nour Baalbaki, Bianca Aprilliano, Christopher Giuliano, Carrie Hartner, and Leonard B. Johnson. "1297. Azithromycin vs Beta Lactams in Acute Exacerbations of COPD." Open Forum Infectious Diseases 8, Supplement_1 (2021): S737. http://dx.doi.org/10.1093/ofid/ofab466.1489.

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Abstract Background Bacterial infections cause approximately 50% of Acute Exacerbations of COPD (AECOPD). Current guidelines recommend a wide range of antibiotics, but evidence comparing agents is limited. The purpose of this study is to compare the effectiveness of azithromycin to beta lactams in the treatment of hospitalized patients with AECOPD. Methods A multicenter, retrospective, observational study of adult patients admitted with AECOPD who received at least two consecutive days of either a beta lactam or azithromycin were included. The primary endpoint was treatment failure which is a

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SADEGHI DEYLAMDEH, Zahra, and Abolfazl JAFARI SALES. "Evaluation of the presence of AmpC (FOX) beta-lactamase gene in clinical strains of Escherichia coli isolated from hospitalized patients in Tabriz, Iran." Journal of Experimental and Clinical Medicine 38, no. 3 (2021): 301–4. http://dx.doi.org/10.52142/omujecm.38.3.17.

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Beta-lactamases are the most common cause of bacterial resistance to beta-lactam antibiotics. AmpC-type beta-lactamases hydrolyze cephalosporins, penicillins, and cephamycins. Therefore, the study aims was to determine antibiotic resistance and to investigate the presence of AmpC beta-lactamase gene in clinical strains of Escherichia coli isolated from hospitalized patients in Tabriz. In this cross-sectional descriptive study, 289 E. coli specimens were collected from clinical specimens. Disk diffusion method and combined disk method were used to determine the phenotype of extended spectrum β-

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Mondragón-Quiguanas, Alejandra, Miguel Ángel Villaquirán-Muriel, Sandra Patricia Rivera, et al. "Beta-Lactam-Resistant Enterobacterales Isolated from Landfill Leachates." Pathogens 11, no. 10 (2022): 1077. http://dx.doi.org/10.3390/pathogens11101077.

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Antibiotic resistance is one of the main challenges worldwide due to the high morbidity and mortality caused by infections produced by resistant bacteria. In Colombia, this problem has been studied mainly from the clinical perspective; however, it is scarcely studied in the leachates produced in landfills. The objective of this study was to detect, identify and determine the antibiotic sensitivity profile of Enterobacterales isolated from a leachate treatment plant located in Cali, Colombia. Detection was performed using selective culture media, bacterial identification using Matrix-Assisted L

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Tune, Bruce M., and Chieh-Yin Hsu. "Mechanisms of beta-lactam antibiotic nephrotoxicity." Toxicology Letters 53, no. 1-2 (1990): 81–86. http://dx.doi.org/10.1016/0378-4274(90)90098-7.

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Bush, K. "Beta-lactamase inhibitors from laboratory to clinic." Clinical Microbiology Reviews 1, no. 1 (1988): 109–23. http://dx.doi.org/10.1128/cmr.1.1.109.

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beta-Lactamases constitute the major defense mechanism of pathogenic bacteria against beta-lactam antibiotics. When the beta-lactam ring of this antibiotic class is hydrolyzed, antimicrobial activity is destroyed. Although beta-lactamases have been identified with clinical failures for over 40 years, enzymes with various abilities to hydrolyze specific penicillins or cephalosporins are appearing more frequently in clinical isolates. One approach to counteracting this resistance mechanism has been through the development of beta-lactamase inactivators. beta-Lactamase inhibitors include clavulan

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Abou Bakr, Attique, Naeem Aslam, Mamoona Ghias, and Imran Mehfooz. "TO DETERMINE THE FREQUENCY OF CLOSTRIDIUM DIFFICILE INFECTION IN ANTIBIOTIC ASSOCIATED DIARRHEA." Journal of Akhtar Saeed Medical & Dental College 05, no. 01 (2023): 38–42. https://doi.org/10.51127/jamdcv5i1oa06.

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Background: Antibiotic associated diarrhea (AAD) is characterized by loose, watery stools, three or more times a day after intake of antibiotics.It is important to exclude all other possible causes of diarrhea before labeling it AAD. To determine the frequency of clostridium difficile infection in antibiotic associated diarrhea. Material and Methods: It was a cross sectional studydone in department of Gastroenterology, outpatient clinic,and ward, AIMC/ Jinnah Hospital, Lahorefrom 23 May 2019 to 23 November 2020. 234 patients fulfilling the selection criteria were enrolled in the study from the

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Escalona, José, Dagoberto Soto, Vanessa Oviedo, et al. "Beta-Lactam Antibiotics Can Be Measured in the Exhaled Breath Condensate in Mechanically Ventilated Patients: A Pilot Study." Journal of Personalized Medicine 13, no. 7 (2023): 1146. http://dx.doi.org/10.3390/jpm13071146.

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Different techniques have been proposed to measure antibiotic levels within the lung parenchyma; however, their use is limited because they are invasive and associated with adverse effects. We explore whether beta-lactam antibiotics could be measured in exhaled breath condensate collected from heat and moisture exchange filters (HMEFs) and correlated with the concentration of antibiotics measured from bronchoalveolar lavage (BAL). We designed an observational study in patients undergoing mechanical ventilation, which required a BAL to confirm or discard the diagnosis of pneumonia. We measured

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Caselli, Desiree, and Olivia Paolicchi. "Empiric antibiotic therapy in a child with cancer and suspected septicemia." Pediatric Reports 4, no. 1 (2012): 2. http://dx.doi.org/10.4081/pr.2012.e2.

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Improved outcome in the treatment of in childhood cancer results not only from more aggressive and tailored cancer-directed therapy, but also from improved supportive therapy and treatment of life-threatening infectious complications. Prompt and aggressive intervention with empiric antibiotics has reduced the mortality in this group of patients. Physical examination, blood tests, and blood cultures must be performed, and antibiotic therapy must be administered as soon as possible. Beta-lactam monotherapy, such as piperacillin-tazobactam or cefepime, may be an appropriate empiric therapy of cho

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Salamone, Francine R. "Sulbactam/Ampicillin." Infection Control & Hospital Epidemiology 9, no. 7 (1988): 323–27. http://dx.doi.org/10.1086/645863.

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Sulbactam/ampicillin was recently marketed for use in several infections caused by beta-lactamase-producing organisms. Sulbactam is the second beta-lactamase inhibitor to become available in the United States. Interest in inhibition of beta-lactamases arose in the late 1960s when a combination consisting of an antibacterial agent and an enzyme inhibitor was found effective in the treatment of certain resistant gram-negative infections. It is now well accepted that the addition of a beta-lactamase inhibitor to a beta-lactam antibiotic may expand its usefulness in a variety of infections.The pen

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Vondracek, Thomas G. "Beta-Lactam Antibiotics: Is Continuous Infusion The Preferred Method of Administration?" Annals of Pharmacotherapy 29, no. 4 (1995): 415–24. http://dx.doi.org/10.1177/106002809502900413.

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Objective: To examine the pharmacodynamic properties of the beta-lactam class of antibiotics and the rationale for their continuous infusion (CI), and to explore reasons that this mode of administration has not replaced intermittent infusion as the standard of practice. Data Sources: A MEDLINE search of the English-language literature evaluating CI administration of beta-lactam antibiotics was conducted. Bibliographic searches of these articles also were performed. Study Selection: Because there were few human trials, all available trials were considered for review. A cross section of clinical

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Hillyer, Trae, and Woo Shik Shin. "Meropenem/Vaborbactam—A Mechanistic Review for Insight into Future Development of Combinational Therapies." Antibiotics 13, no. 6 (2024): 472. http://dx.doi.org/10.3390/antibiotics13060472.

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Beta-lactam antibiotics have been a major climacteric in medicine for being the first bactericidal compound available for clinical use. They have continually been prescribed since their development in the 1940s, and their application has saved an immeasurable number of lives. With such immense use, the rise in antibiotic resistance has truncated the clinical efficacy of these compounds. Nevertheless, the synergism of combinational antibiotic therapy has allowed these drugs to burgeon once again. Here, the development of meropenem with vaborbactam—a recently FDA-approved beta-lactam combination

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Wong, Tiffany, Adelle Atkinson, Geert t’Jong, Michael J. Rieder, Edmond S. Chan, and Elissa M. Abrams. "Beta-lactam allergy in the paediatric population." Paediatrics & Child Health 25, no. 1 (2020): 62. http://dx.doi.org/10.1093/pch/pxz179.

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Abstract Beta-lactam allergy is commonly diagnosed in paediatric patients, but over 90% of individuals reporting this allergy are able to tolerate the medications prescribed after evaluation by an allergist. Beta-lactam allergy labels are associated with negative clinical and administrative outcomes, including use of less desirable alternative antibiotics, longer hospitalizations, increasing antibiotic-resistant infections, and greater medical costs. Also, children with true IgE-mediated allergy to penicillin medications are often advised to avoid all beta-lactam antibiotics, including cephalo

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Ruotsalainen, Pilvi, Cindy Given, Reetta Penttinen, and Matti Jalasvuori. "Beta-Lactam Sensitive Bacteria Can Acquire ESBL-Resistance via Conjugation after Long-Term Exposure to Lethal Antibiotic Concentration." Antibiotics 9, no. 6 (2020): 296. http://dx.doi.org/10.3390/antibiotics9060296.

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Beta-lactams are commonly used antibiotics that prevent cell-wall biosynthesis. Beta-lactam sensitive bacteria can acquire conjugative resistance elements and hence become resistant even after being exposed to lethal (above minimum inhibitory) antibiotic concentrations. Here we show that neither the length of antibiotic exposure (1 to 16 h) nor the beta-lactam type (penam or cephem) have a major impact on the rescue of sensitive bacteria. We demonstrate that an evolutionary rescue can occur between different clinically relevant bacterial species (Klebsiella pneumoniae and Escherichia coli) by

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Mayasari, Ayudiah Puspita. "Klebsiella pneumoniae IDENTIFICATION OF PRODUCING EXTENDED SPECTRUM BETA LACTAMASE (ESBL) AND RESISTANCE PATTERN OF ANTIBIOTICS IN ULIN GENERAL HOSPITAL BANJARMASIN." Berkala Kedokteran 13, no. 2 (2017): 161. http://dx.doi.org/10.20527/jbk.v13i2.4071.

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Abstract: Klebsiella pneumoniae(K. pneumoniae) can synthesize beta lactamase enzymes that have the ability to open lactam beta rings and cause resistance to antibiotics such as amoxicillin, third generation cephalosporins namely cefotaxim, ceftazidim, ceftriaxone and monobactam groups such as aztreonam. Extended spectrum beta lactamase (ESBL) is a plasmid enzyme that mediates the occurrence of hydrolysis and inactivation of beta lactam antibiotics. Infections caused by ESBL-producing bacteria become a serious problem for hospitals worldwide. ESBL isolate susceptibility tests against antibiotic

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Ishikawa, Kazuhiro, Tomoaki Nakamura, Fujimi Kawai, Erika Ota, and Nobuyoshi Mori. "Systematic Review of Beta-Lactam vs. Beta-Lactam plus Aminoglycoside Combination Therapy in Neutropenic Cancer Patients." Cancers 16, no. 10 (2024): 1934. http://dx.doi.org/10.3390/cancers16101934.

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We performed a systematic review of studies that compared beta-lactams vs. beta-lactams plus aminoglycosides for the treatment of febrile neutropenia in cancer patients. Method: We searched CENTRAL, MEDLINE, and Embase for studies published up to October 2023, and randomized controlled trials (RCTs) that compared anti-Pseudomonas aeruginosa beta-lactam monotherapy with any combination of an anti-Pseudomonas aeruginosa beta-lactam and an aminoglycoside were included. Result: The all-cause mortality rate of combination therapy showed no significant differences compared with that of monotherapy (

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Vázquez-López, Rosalino, Tanya Hernández-Martínez, Selene Ivonne Larios-Fernández, et al. "Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections." Antibiotics 12, no. 9 (2023): 1355. http://dx.doi.org/10.3390/antibiotics12091355.

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Nosocomial infections caused by Escherichia coli pose significant therapeutic challenges due to the high expression of genes encoding antimicrobial drug resistance. In this study, we investigated the conformation of the beta-lactam resistome responsible for the specific pattern of resistance against beta-lactam antibiotics. A total of 218 Escherichia coli strains were isolated from in-hospital patients diagnosed with nosocomial infections, obtained from various sources such as urine (n = 49, 22.48%), vaginal discharge (n = 46, 21.10%), catheter tips (n = 14, 6.42%), blood (n = 13, 5.96%), fece

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Staicu, Mary L., Tyler Baumeister, and Maryrose R. Laguio-Vila. "254. Review of Clinical Outcomes in Patients Treated with Beta-lactam vs Non-beta-lactam Therapy for AmpC Producing Bacterial Bloodstream Infections." Open Forum Infectious Diseases 7, Supplement_1 (2020): S126. http://dx.doi.org/10.1093/ofid/ofaa439.298.

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Abstract Background AmpC beta-lactamase producing organisms are traditionally treated with carbapenem or fluoroquinolone antibiotics. Recent studies, however, describe similar clinical outcomes in patients that receive cefepime or piperacillin/tazobactam. We sought to assess outcomes in patients with bloodstream infections caused by AmpC-producing organisms that received beta-lactams compared non-beta-lactam therapy. Methods Data was obtained retrospectively from the electronic health record (EHR) from January 2012 to February 2020. The primary objective was 30-day mortality from the day of fi

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Alves, Janine F., Guilherme H. Paula, Rânio C. F. Silva, et al. "Residues of antibiotics in milk: persistence and quality interference." Canadian Journal of Animal Science 100, no. 1 (2020): 93–101. http://dx.doi.org/10.1139/cjas-2018-0224.

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The objective of this study was (i) to analyze antibiotic residues, two which were beta-lactam antibiotics, one tetracycline, and one quinolone in the milk of lactating animals; (ii) to evaluate the interference of the drug ceftiofur which is considered as discard-zero. The SNAPduo™ ST Plus kit was used to evaluate the presence of beta-lactam antibiotics and tetracyclines in natural milk. Medications based on penicillin, ceftiofur, enrofloxacin, and oxytetracycline were used. As expected, the milk from control animals and animals administered with enrofloxacin did not present antibiotic residu

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Syromyatnikov, M. Yu, S. V. Shabunin, E. Yu Nesterova, et al. "ABUNDANCE OF BACTERIAL ANTIBIOTIC RESISTANCE GENES IN SWINE DURING THE FATTENING PERIOD (SUS SCROFA DOMESTICUS)." Transactions of the educational establishment “Vitebsk the Order of “the Badge of Honor” State Academy of Veterinary Medicine 59, no. 4 (2023): 96–101. http://dx.doi.org/10.52368/2078-0109-2023-59-4-96-101.

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The aim of the study was to analyze the gut microbiome of swine during the fattening period, aimed at identify-ing antibiotic resistance genes. High-throughput sequencing allowed a total of 119 636 readings, bioinformatic re-search of which revealed 17 antibiotic resistance genes belonging to 4 classes of antibiotics: tetracyclines (81%), beta-lactam antibiotics (11%), erythromycins (7%) and aminoglycosides (1%). Among the 5 detected tetracycline resistance genes, the gene Tet(W) dominated, the percentage of which was 73% of the number of all tetracycline antibiotic resistance genes. Erythromy

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Sinkó, János. "Antibiotikumokkal szemben ellenálló Gram-negatív baktériumok okozta súlyos fertőzések a klinikus szemével. A Birodalom visszavág?" Orvosi Hetilap 158, no. 39 (2017): 1528–34. http://dx.doi.org/10.1556/650.2017.30858.

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Abstract: In our days, growing incidence of antibiotic resistant bacteria has become an eminent public health problem. For survival Gram-negative species possess several different tools to withstand antibiotics: they produce degrading and modifying enzymes, decrease their permeability or expel drug molecules. An increasing proportion of severe nosocomial infections are caused by strains resistant to several antimicrobials (multiresistant, extensively resistant or panresistant species). Development of new antibiotic compounds may serve as a possible solution to this problem. Ceftolozane-tazobac

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Odeny, Bonnita, George Asudi, George Omwenga, Richard Oduor, and Geoffrey Karau. "Analysis of Antibiotics in Milk from Smallholder Farmers from Kenya Shows Traces Above the Recommended Maximum Residue Limits." International Journal of Food Science and Biotechnology 9, no. 2 (2024): 27–39. http://dx.doi.org/10.11648/j.ijfsb.20240902.12.

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Antimicrobial resistance (AMR) is rising globally and is likely to cause more deaths because of antibiotic-resistant microbial infections and antibiotic residues in animal foods and products as a result of misuse of antibiotics in dairying. Thus, we determined the presence and quantities of sulfonamide, tetracycline, and beta-lactam drug residues in milk sampled in Nyandarua, Meru, and Kiambu counties in Kenya using the Charm TRIO® test kit and liquid chromatography (LC) coupled to the triple quadrupole mass spectroscopy (MS) (LC-MS/MS). The TRIO® test kit showed dicloxacillin as the most prev

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Neu, Harold C. "Aztreonam: A novel monocyclic beta-lactam antibiotic." American Journal of Medicine 78, no. 2 (1985): 1. http://dx.doi.org/10.1016/0002-9343(85)90195-0.

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Rubinstein, Ethan, and Ruth Lang. "Once-A-Day Beta-Lactam Antibiotic Administration." Journal of Clinical Pharmacology 32, no. 8 (1992): 711–15. http://dx.doi.org/10.1002/j.1552-4604.1992.tb03874.x.

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Y., E. SALEH, A. M. ABO-STATE M., L. HELAL N., and M. GHAREEB H. "AMINOGLYCOSIDE AND BETA–LACTAM RESISTANCE PATTERN AMONG GRAM NEGATIVE BACILLI (GNB) ISOLATED FROM EGYPTIAN HOSPITALS BETWEEN 2012-2014." Asian Journal of Microbiology and Biotechnology 2, no. 1 (2017): 20–29. https://doi.org/10.5281/zenodo.1407367.

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<strong>Aims:</strong> Antibiotic resistance is a problem of deep scientific concern both in hospital and community settings. The present study aims to monitor the prevalence of aminoglycoside and beta-lactam antibiotics resistance of Cairo, Egypt. <strong>Methodology and Results:</strong> A total of 210 bacterial strains were isolated from urine, wound, sputum, endotracheal tube (ETT), pus and blood, which recovered from three hospitals and Central health laboratories during four periods between May 2012 to March 2014. All the isolates were Gram negative bacilli (GNB), the most prevalent path

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Imburgia, Taylor A., and Michelle L. Kussin. "A Review of Extended and Continuous Infusion Beta-Lactams in Pediatric Patients." Journal of Pediatric Pharmacology and Therapeutics 27, no. 3 (2022): 214–27. http://dx.doi.org/10.5863/1551-6776-27.3.214.

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Intravenous beta-lactam antibiotics are the most prescribed antibiotic class in US hospitalized patients of all ages; therefore, optimizing their dosing is crucial. Bactericidal killing is best predicted by the time in which beta-lactam drug concentrations are maintained above the organism's minimum inhibitory concentration (MIC), rather than achievement of a high peak concentration. As such, administration of beta-lactam antibiotics via extended or continuous infusions over a minimum of 3 hours, rather than standard infusions over approximately 30 minutes, has been associated with improved ac

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Sato, Masanori, Noriko Kubota, Yoshihiko Katsuyama, et al. "Case report of a 6-year-old girl with Mycoplasma hominis ventriculoperitoneal shunt infection." Journal of Neurosurgery: Pediatrics 19, no. 5 (2017): 620–24. http://dx.doi.org/10.3171/2017.1.peds16520.

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Mycoplasma hominis is a rare causative pathogen for surgical site infections after neurosurgical procedures. This organism lacks a cell wall, rendering it undetectable by Gram staining and making it resistant to beta-lactam antibiotics. In addition, some special techniques are required to identify this organism. Thus, it is very difficult to diagnose infections caused by this pathogen. Here, the authors report a pediatric case of M. hominis ventriculoperitoneal shunt (VPS) infection with central nervous system involvement for which beta-lactam antibiotics were not effective and Gram staining r

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Janhavi, Bora*1 Tejal Bhalshankar2 Samadhan Anarase3 Vaisnavi Gadilkar4 Shubham Gaikawad5 Dr. Shoheb Shaikh6. "Advanced Analytical Strategies for Antibiotic Quantification: A Comparative Study of UV Spectroscopy and HPLC." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 883–904. https://doi.org/10.5281/zenodo.15349720.

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The development and validation of analytical methods are critical for ensuring the quality, efficacy, and safety of pharmaceuticals, particularly beta-lactam antibiotics. These antibiotics, known for their ability to inhibit bacterial cell wall synthesis, remain indispensable in combating a wide range of infections despite growing concerns about antibiotic resistance. This review focuses on the advancements in analytical methodologies, including UV-Vis spectroscopy and high-performance liquid chromatography (HPLC), which are pivotal in the characterization, quantification, and stability assess

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