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Dissertations / Theses on the topic 'Bio Peptone'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kasturiarachchi, Jagath Chandana. "Bio-oligomers as antibacterial agents and strategies for bacterial detection." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10030.

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In this thesis I examined the potential of Bio-Oligomers such as peptoids, peptides and aptamers, as therapeutic and diagnostic entities. Therapeutic Bio-Oligomers; A series of peptoid analogs have been designed and synthesised using solid phase synthesis. These peptoids have been subjected to biological evaluation to determine structure-activity relationships that define their antimicrobial activity. In total 13 peptoids were synthesised. Out of 13 different peptoids, only one peptoid called Tosyl-Octyl-Peptoid (TOP) demonstrated significant broad-spectrum bactericidal activity. TOP kills bac

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2

Guerinot, Cassandra. "Conception bio-inspirée d'architectures moléculaires amphiphiles pour combattre les infections bactériennes." Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2024. http://theses.bu.uca.fr/nondiff/2024UCFA0085_GUERINOT.pdf.

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Les peptides antimicrobiens (PAMs) sont considérés comme des composants clés du système immunitaire inné. Leur intérêt repose sur leur large spectre d'activités et leur faible propension à induire des résistances bactériennes, faisant d'eux une bonne alternative aux antibiotiques actuels. Malheureusement, leur utilisation thérapeutique est souvent entravée par une mauvaise pharmacocinétique et un coût élevé. Toutefois, les PAMs sont une grande source de bio-inspiration pour le développement de peptidomimétiques, conçus pour reproduire le mécanisme d'action des PAMs tout en améliorant le profil

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Trudgian, David Claude. "Novel Bio-Kernel Networks for Peptide Classification." Thesis, University of Exeter, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486509.

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The classification of peptides, drawn from protein sequences, is a common problem in bioinformatics research. Examples of peptide classification problems include the identification of viral protein binding sites, which may be suitableÃ‚Â· targets for drugs, and the identification of signal peptides, which are important in regulating processes within cells. Many computational approaches have been applied to peptide classification ranging from relatively simple statistical analysis, through template based pattern matching, to state-of-the art machine learning techniques. In recent years artifici

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4

Koh, Liling. "Investigations of bio-responsive peptide-inorganic nanomaterials." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/1376.

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Growth in nanotechnology has been fuelled by miniaturization of electronic systems, development of biomedical sciences and interest in nanomaterials that exhibit interesting properties. Current techniques to fabricate small devices have difficulty in accessing the size range between 10-100 nm, and conjugation of biomolecules with inorganic nanoparticles (NPs) can potentially be used to bridge this gap. Biological functions of living cells operate in the nanoscale and there is great potential in using bionanotechnology to discover new biomedical applications in diagnostics, drug delivery and ca

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Wu, Ming-Cheng. "Bio-engineering of antibiotic enduracidin biosynthetic pathways and PreQ1 riboswitch." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/bioengineering-of-antibiotic-enduracidin-biosynthetic-pathways-and-preq1-riboswitch(5eb04bf7-f20b-49d0-96f6-cd06f92676d1).html.

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Non-ribosomally synthesised natural products derived mainly from bacteria and fungi act as important therapeutic agents. Due to their complex structures it is difficult to chemically synthesise such compounds, therefore the engineering of biosynthetic and biocatalytic pathways that are vital for their production are the aims of this thesis. The first project involved the study of the biosynthesis of 3-O-methyl aspartic acid (OmAsp) in the antibiotic A54145. We demonstrated that LptL functions as an asparagine hydroxylase. We also predicted that LptJ and LptK are involved in the biosynthesis of

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Frasson, Nicola <1993&gt. "Computational methods to develop novel peptide inhibitors." Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/16128.

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Computational drug design has gained an increasing interest in the last decade, revealing promising results in the discovery of novel therapeutic candidates. Both ab initio and de novo approaches enable the study and screening of a large number of molecules in silico, thus restraining the use of expensive and time-consuming experimental techniques. This thesis regards the attempt to use different computational methods (mainly Machine Learning and Direct Coupling Analysis approach) to predict novel peptide-based inhibitors of human urokinase-type plasminogen activator (uPA), an enzyme involved

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7

Oteng-Pabi, Samuel. "Identification and Characterization of Peptide Substrates of Bacterial Transglutaminases for Use in Bio-conjugation and Bio-catalytic Applications." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36184.

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Transglutaminases (protein-glutamine:amine y-glutamyl- transferase, EC 2.3.2.13) are a family of calcium-dependent enzymes which catalyze an acyl transfer between glutamine residues and a wide variety of primary amines. When lysine acts as the acyl-acceptor substrate, α-glutamyl lysine isopeptide bond is formed. Isopeptide catalyzation results in protein cross-linkage which is prevalent throughout biological processes. Microbial transglutaminase (mTG) is a bacterial variant of the transglutaminase family, distinct by virtue of its calcium-independent catalysis of the isopeptidic bond. Further

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Mazzocato, Ylenia <1995&gt. "Development of novel peptide-based inhibitors of cancer-associated proteases." Master's Degree Thesis, Università Ca' Foscari Venezia, 2021. http://hdl.handle.net/10579/18915.

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Nell'ultimo decennio, i farmaci a base di peptidi hanno suscitato un crescente interesse grazie alle loro proprietà (riconoscimento selettivo del bersaglio, legame ad alta affinità e bassa tossicità) e applicabilità in ambito terapeutico. Nella prima fase del progetto sono stati prodotti e caratterizzati ventotto peptidi biciclici come inibitori dell’attivatore del plasminogeno urochinasi umano (huPA), una serina proteasi associata alla progressione del cancro e alle metastasi. I peptidi sono stati prodotti utilizzando la sintesi di peptidi in fase solida (SPPS), la reazione di biciclizzazione

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9

Aguesseau, Julie. "Design of bio-inspired catalysts based on a gamma-peptide foldamer architecture." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTS043/document.

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Les travaux décrits dans ce manuscrit concernent la synthèse d’oligomères de γ-amino acides hétérocycliques contraints, appelés ATCs (acides 4-Amino-(méthyl)-1,3-Thiazole-5-Carboxyliques), leur application en catalyse énamine et leur étude structurale. Les monomères d’ATC sont construits autour d’un noyau thiazole inséré entre les carbones Cα-Cβ, permettant de limiter la valeur de l’angle dièdre ζ à 0°. La présence de deux points de substitution, sur le carbone γ asymétrique et en position 2 du noyau aromatique, permet une large diversification structurale des ATCs. Ainsi, plusieurs séries d’o

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10

FERRARI, Federica. "Pharmacological profile of nociceptin/orphanin FQ receptor – characterization of novel peptide and non peptide ligands." Doctoral thesis, Università degli studi di Ferrara, 2017. http://hdl.handle.net/11392/2478798.

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Il peptide nocicettina/orfanina FQ (N/OFQ) è il ligando endogeno del recettore NOP; questo sistema peptidergico controlla diverse funzioni biologiche sia nel sistema nervoso centrale che in periferia. Lo scopo del presente studio è stata la caratterizzazione farmacologica di nuovi ligandi peptidici e non-peptidici per il recettore NOP. Una serie di composti N/OFQ dimerici e l’antagonista PWT2-UFP-101 sono stati progettati e sintetizzati nella nostra Università, mentre i ligandi non-peptidici investigati provengono da case farmaceutiche. Tutti i composti sono stati valutati in vitro in diversi

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11

Evans, David Andrew. "Exploitation of peptide aptamers in the design and development of electronic-bio-hybrid devices." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507692.

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12

Chiaramonte, M. L. "BIOCHEMICAL AND FUNCTIONAL ANALYSIS OF NF-YA CELL PENETRATING PEPTIDE PROPERTIES IN DIFFERENT CELL SYSTEMS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/335187.

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1. Abstract The transcription factor NF-Y is a trimeric complex composed by three subunits NF-YA, NF-YB and NF-YC, which specifically recognizes and binds the CCAAT box sequence, present in almost 30% of eukaryotic promoters. NF-YB and NF-YC contain a histone fold domain, structurally related to H2A and H2B and they dimerize head to tail; NF-YA exists in two different isoforms and it is thought to be the regulatory subunit of the trimer. NF-Y is a key regulator of cell cycle progression and it regulates different metabolic pathways in proliferating cells. In the last years, it also emerged a

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13

LUCA, V. DE. "Significato del peptide ghrelina nel mantenimento dell'integrità della mucosa gastrica : ruolo del nitrossido e delle prostaglandine." Doctoral thesis, Università degli Studi di Milano, 2008. http://hdl.handle.net/2434/63162.

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14

Hammi, Ikram. "Isolement et caractérisation de bactériocines produites par des souches de bactéries lactiques isolées à partir de produits fermentés marocains et de différentes variétés de fromages français." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF028/document.

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Les bactériocines sont des peptides antimicrobiens produits par des bactéries naturellement immunisées contre leurs propres bactériocines. Ce travail a permis l’identification de nombreuses souches productrices de peptides antimicrobiens. Ces derniers ont été extraits et purifiés par différentes techniques chromatographiques, puis identifiés et caractérisés par la mesure de leurs masses et par l’analyse de leurs structures (approche protéomique et séquençage d’Edman). Parmi les résultats obtenus, il y a :- la mise en évidence d’une nouvelle bactériocine (maltaricin CPN), appartenant à la class

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15

Sugisita, Kenichi. "Biophysical Studies on Interactions of a Host Defense Peptide, Magainin 2, with Lipid-and Bio-Membranes." 京都大学 (Kyoto University), 1997. http://hdl.handle.net/2433/202499.

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16

Ferro, Camilla <1994&gt. "Synthesis and characterisation of the binding mode of a lipidated peptide in complex with a serum protein using analytical mass spectrometry." Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/15966.

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The human serum albumin is the drug carrier for many substances within the human body. The aim of this thesis is to identify the binding epitope of a lipid-modified peptide able to bind serum albumin with high affinity and specificity. Toward this goal, we synthesised and purified the lipidated peptide, and characterised its interaction with the protein by using advanced mass-spectrometry techniques such as tandem mass spectrometry and native mass spectrometry.

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17

Shah, Kinjalkumar K. "Design, Synthesis and Characterization of Heme-proteins: Developing Potential Catalysts for Bio-remediation." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/31187.

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The next generation of toxic chemicals and hazardous wastes from sophisticated chemical industries will demand the environmental agencies to employ biological methods over the conventional physical and chemical remediation methods. Over the past decade, natural metallo-enzymes have been identified to degrade some of the major chemical contaminants through electron transfer pathways. However, these natural enzymes are less stable in organic solvents and they are not effective for the degradation of toxic compounds such as polychlorinated biphenyls or dioxins. This thesis explores the use of pro

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18

Sang, Sheila J. "The Use of Phage Display to Identify Specific Peptide Ligands." Youngstown State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1409923241.

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19

Gresika, Alexandra. "Nouveaux synthons contraints de type α-amino acides et PNA en vue de l’élaboration de bio-foldamères". Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4104/document.

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Le but de cette thèse a concerné le développement de deux types de structures oligomériques contraintes, basées soit sur des dérivés non naturels d’acides aminés cycliques, soit sur des dimères cycliques de Peptide Nucleic Acids (PNA), en vue d’analyser leur tendance à adopter des conformations pré-organisées, imitant les conformations actives des protéines ou des acides nucléiques. La première partie de cette thèse a trait à l’élaboration de synthons clefs dérivant d’acides α-aminés cycliques non naturels (acides 4-oxopipécoliques 6-substitués), à leur utilisation potentielle dans la synthèse

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20

Godzaridis, Élénie. "Modélisation bio-informatique du mécanisme d'action d'inhibiteurs de la voie de biosynthèse du peptidoglycane." Master's thesis, Université Laval, 2012. http://hdl.handle.net/20.500.11794/23561.

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La résistance développée par les bactéries aux antibiotiques est un problème d'échelle mondiale qui a récemment attiré beaucoup d'intérêt. En effet, particulièrement chez les bactéries à Gram-négatif, on constate une depletion rapide de la quantité d'antibiotiques efficaces. De nos jours, les programmes de recherche de nouveaux antibiotiques commencent souvent par le criblage de cibles cellulaires. Les enzymes Mur, impliquées dans la biosynthèse de la paroi, sont uniques aux cellules bactériennes et nécessaires à leur survie. Le présent mémoire décrit l'utilisation des méthodes de bio-informat

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21

Romeo, Giulietta. "Studio degli aspetti bio-molecolari responsabili della differenziazione di UCB-SC verso cellule insulino secernenti in diverse condizioni sperimentali." Thesis, Universita' degli Studi di Catania, 2011. http://hdl.handle.net/10761/365.

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La ricerca sulle cellule staminali e' concentrata sull'obiettivo di riuscire a controllarne il differenziamento con lo scopo di ottenere cellule differenziate in uno qualsiasi dei tessuti di volta in volta necessario per fini terapeutici. Queste cellule forniscono importanti informazioni sui meccanismi di controllo genetico ed epigenetico dello sviluppo, e possono rendere attuali e reali trattamenti terapeutici per gravi malattie genetiche e per malattie degenerative. Lo scopo del progetto di ricerca e' stato quello di individuare un protocollo sperimentale che, utilizzando cellule staminali

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22

Kas, Onur Y. "Design, synthesis and characterization of bio/electroactive hybrids confining chromophores in dilute solutions using a helical peptide template /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 148 p, 2008. http://proquest.umi.com/pqdweb?did=1459918061&sid=4&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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BROGNARA, Eleonora. "Biological activity of anti-miR-221 Peptide Nucleic Acids and relative building blocks." Doctoral thesis, Università degli studi di Ferrara, 2012. http://hdl.handle.net/11392/2389258.

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The study of new molecules able to selectively and stably interact with DNA and RNA is a field of great interest in consideration all the possible applications in medicine. Our study is related to the biomedical applications of the final product of PNA synthesis (the PNA itself) and the intermediate molecules obtained during the synthetic activity. In all the chemical synthesis approach of any pharmaceutical laboratory several molecules are produced, which are usually not considered for biological assays and technology transfer. We screened a set of C(5) uracil derivatives monomers, tha

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Strauss, Jörg. "Optisch aktive chromophorfunktionalisierte Cyclo- und Hairpinpeptide Synthese, Elektrochemie, Spektroskopie /." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964806177.

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Hahn, Markus. "Chromatographische, NMR-spektroskopische und massenspektrometrische Untersuchungen der Reaktionen von histidin- und methioninhaltigen Peptiden mit [Pt(dien)(H2O)]2+, [Pt(en)(H2O)2)]2+ und cis-[PtCl2(NH3)2]." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=960640940.

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Olszewski, Amy L. "Synthesis, Biological Functionalization, and Integration ofCarbon Nanotubes for Bio-Sensing Textiles." Youngstown State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1369854838.

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27

DI, STASI ADRIANA. "Il peptide antimicrobico B7-005: biocompatibilità, modalità d'azione e attività antimicrobica contro i patogeni ESKAPE." Doctoral thesis, Università degli Studi di Trieste, 2023. https://hdl.handle.net/11368/3042424.

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L'Organizzazione Mondiale della Sanità ha elencato alcuni patogeni resistenti alla maggior parte degli antibiotici e responsabili della maggior parte delle infezioni nosocomiali. Questi patogeni sono indicati con l'acronimo ESKAPE: E. faecium, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa ed Enterobacter spp. Sono urgentemente necessari nuovi farmaci che superino la resistenza agli antibiotici di questi patogeni. Grandi speranze sono rivolte ai peptidi antimicrobici ricchi di proline (PrAMP). I PrAMP presentano un'attività antimicrobica potente e specifica, penetrano in alcune specie b

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Fallarino, Lorena. "Anti HIV-1 gene therapy approach combining multiple siRNAs with the membrane-anchored fusion inhibitor C-peptide maC46." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3426674.

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The development of highly active anti-retroviral therapy (HAART) has considerably improved life expectancy of HIV-1 positive patients by transforming this infection, which once was lethal, into a manageable chronic illness. Although a significant suppression of viral replication under undetectable level is guaranteed following a constant therapeutic adherence, this therapy fails to completely eliminate the infection due to the persistence of HIV-1 into reservoirs, which represent therefore the main obstacle to a definite cure. Furthermore, a lifelong adherence to treatment is associated with d

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Belvedere, Raffaella. "Role of Annexin A1 in tumor progression." Doctoral thesis, Universita degli studi di Salerno, 2016. http://hdl.handle.net/10556/2492.

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2014 - 2015<br>Annexin 1 (ANXA1) is a multifunctional protein of 37 kDa, and represents the first characterized member of the annexin superfamily, so called since their main property is to bind (i.e. to annex) cell membranes in Ca2+-dependent manner. ANXA1 is over-expressed in tissues from patients affected by pancreatic carcinoma (PC), where the protein seems to be associated with the malignant transformation and the poor prognosis. In this PhD project, experiments were performed to understand the role of ANXA1 in human PC development with particular attention to migration and invasion proces

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Mueller, Lena Verfasser], Alesia [Akademischer Betreuer] [Tietzte, and Gerhard [Akademischer Betreuer] Thiel. "Chemical synthesis of switchable peptide-based nanopores: from ion channels to bio-inspired materials / Lena Mueller ; Alesia A. Tietze, Gerhard Thiel." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2019. http://d-nb.info/1211478009/34.

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Mueller, Lena [Verfasser], Alesia A. [Akademischer Betreuer] Tietze, and Gerhard [Akademischer Betreuer] Thiel. "Chemical synthesis of switchable peptide-based nanopores: from ion channels to bio-inspired materials / Lena Mueller ; Alesia A. Tietze, Gerhard Thiel." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2019. http://d-nb.info/1211478009/34.

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Guerin, Mathilde. "Synthèse one-pot de nanoparticules d'apatite bio-inspirées entourées par de nouveaux agents stabilisants bioactifs à base de peptides : vers une application pour la cicatrisation des plaies." Electronic Thesis or Diss., Montpellier, Ecole nationale supérieure de chimie, 2022. http://www.theses.fr/2022ENCM0027.

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Le projet APAPTIDE repose sur la conception, la synthèse et l'étude de particules hybrides d'apatite bio-inspirée stabilisées par une couronne de peptides bioactifs. Ces particules pourront également être dopées par des ions d'intérêts biologiques (ions antibactériens, anti-inflammatoires). Les particules hybrides préparées seront évaluées biologiquement comme une solution alternative aux traitements antibiotiques systémiques générant une résistance microbienne. De ce fait, des peptides antibactériens, pro-angiogéniques et pro-cicatrisants seront utilisés en priorité pour stabiliser les partic

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Naumann, Kai. "Synthetische Peptid-Konjugate in Replikations- und Translationsmodellen." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=970759037.

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COSTA, STEFANO. "PepspotDB: una banca dati per l'immagazzinamento e l'analisi di esperimenti basati sulla tecnologia degli array di peptidi." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/984.

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La mappatura dell'interattoma (la rete composta da tutte le possibili interazioni fisiche proteina-proteina che avvengono naturalmente in una cellula o in un organismo) degli organismi viventi è una risorsa essenziale per promuovere l'avanzamento della Systems Biology. Senza sminuire le tante preziose lezioni che abbiamo appreso dallo studio delle reti di interazioni proteina-proteina, occorre però onestamente riconoscere che gli interattomi attuali presentano diverse limitazioni, tra cui cruciale è la scarsità di informazione sulle regioni proteiche coinvolte nel legame. A questo proposito, r

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Romoli, Ottavia. "Antimicrobial peptide-mediated immune response in four Bombyx mori strains infected with Gram-positive and -negative pathogens." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424450.

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The domesticated silkworm Bombyx mori is an important organism for its intrinsic economic and biotechnological value, but also for representing a model organism for Lepidoptera genetics. Silkworm strains can be grouped into four geographical types (Japanese, Chinese, European and Tropical) characterized by a different resistance to infections, which is inversely correlated to the silk productivity. The aim of this project was to characterize which are the main elements of the immune response protecting Bombyx mori against pathogen infections, with the final purpose to obtain silkworms enhance

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Staveren, Dave Richard van. "Robust transition metal markers for labelling of peptides via solid phase synthesis methods." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962393665.

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SOLA, RICCARDO. "Towards the design of peptide antibiotics: new insights from synthetic analogues and from natural sources." Doctoral thesis, Università degli Studi di Trieste, 2021. http://hdl.handle.net/11368/2988917.

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Resistance to antibiotics is spreading worldwide across bacteria generating an increasing number of multi- and even pan-drug resistant pathogens. Antibiotics currently on the market hardly could keep this threat at bay. In order to overcome this problem, novel classes of drugs with different mechanisms of action are extremely necessary. High hopes are pointed towards antimicrobial peptides (AMPs), natural molecules with multiple defensive roles produced by eukaryotes and bacteria. Among AMPs, proline-rich antimicrobial peptides (PrAMPs) share a generally low cytotoxicity thanks to an intracel

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Busatto, Nicola. "Functional characterization of a ripening induced RGF-like peptide hormone in peach." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422474.

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In the vascular plants the coordination of developmental processes, cell-cell interactions and physiological processes are mediated by the action of phytohormones, whose chemical structures include simple molecules as olefin (ethylene) and complex steroids as brassinolide. Moreover, little signal peptides were recognized to have a role as phytohormones. Such peptides were involved in defense response, callus growth, meristems homeostasis, root growth, organ abscission and hormone crosstalk. The peach peptide encoded by the ctg134 gene represents a possible candidate as mediator in the interpl

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Westergren, Elisabeth. "Analysis of hydrogels for immobilisation of hepatocytes (HepG2) in 3D cell culturing systems." Thesis, Linköpings universitet, Teknisk biologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-145392.

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In pharmaceutical development cell cultures are used as in vitro models to evaluate the function of drug candidates. In such research it is vital to have models that resemble the in vivo environment to get reliable results. In 3D models with hydrogels ECM like scaffolds are supporting the cells in a more in vivo like environment than flat 2D cultures. In this project PEG-peptide based hydrogels with cell binding RGD incorporated on one PEG-peptide type has been evaluated for culturing of HepG2 cells. Structure and viscoelastic properties were evaluated with techniques like circular dichroism s

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Anhettigama, Gamaralalage Medha Jaimini Gunaratna. "Design, synthesis and bio-evaluation of piperidines and CGRP peptides; Synthesis of substituted 6-(dimethylamino)-2-phenylisoindolin-1-ones for the inhibition of luciferase." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/38204.

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Doctor of Philosophy<br>Department of Chemistry<br>Duy H. Hua<br>Three research projects are described in this dissertation, and they are: (i) discovery of piperidine derivatives as T-type calcium channel inhibitors for the treatment of epilepsy and neuropathic pain and as protein disulfide isomerase inhibitors for the treatment of influenza viral infection; (ii) discovery of peptide-based calcitonin gene-related peptide receptor antagonists for the treatment of inflammatory pain; and (iii) synthesis of substituted 6-(dimethylamino)-2-phenylisoindolin-1-ones for the inhibition of luciferase.

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Pelillo, Chiara. "Therapeutic potential of BAC7(I-35), a Proline-rich Antimicrobial Peptide: in vitro and in vivo studies and Pegylation strategy to improve its bioavailability." Doctoral thesis, Università degli studi di Trieste, 2011. http://hdl.handle.net/10077/5978.

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2009/2010<br>The antimicrobial peptides (AMPs) are an important component of the innate defense against invading microorganisms, are widespread in nature and may have multiple and diversified mechanisms of bactericidal action. In addition to their direct antimicrobial activity the are also involved in other biological processes. The aim of this project was to investigate the in vivo activity of Bac7(1-35), a bovine proline-rich antimicrobial peptide, having in mind its possible use as a lead compound for the development of novel anti-infective agents. Before moving to animal models of infecti

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Wortmann, Maria. "[Alpha]- [Alpha] und [gamma]-Peptide [Gamma-Peptide] aus synthetischen Cyclohexan- und Pyrrolidin-Aminosäuren." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=959562605.

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侯嘉俊 and Ka-chun Hau. "Antisense peptides and protein structure." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970539.

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DEGASPERI, MARGHERITA. "Optimization of BMAP-18 an anti-infective peptide for the treatment of pulmonary infection." Doctoral thesis, Università degli Studi di Trieste, 2019. http://hdl.handle.net/11368/2991054.

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I pazienti con infezioni polmonari richiedono un trattamento farmacologico contro agenti patogeni multiresistenti. Il peptide antimicrobico BMAP27 (1-18), una forma troncata di BMAP-27, ha dimostrato di essere attivo in vitro contro forme planctoniche e sessili di ceppi isolati da pazineti con fibrosi cistica di Pseudomonas aeruginosa multiresistenti e Stenotrophomonas maltophilia. Nonostante la buona attività antimicrobica in vitro, non mostra un'attività protettiva in vivo in un modello murino di infezione polmonare acuta da parte di P. aeruginosa e mostra una tossicità residua in vivo. L'in

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Furlan, Michela. "Activity of salmonid antibacterial proteins and regulation of their expression in response to pathogens." Doctoral thesis, Università degli studi di Trieste, 2014. http://hdl.handle.net/10077/10146.

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2012/2013<br>Cathelicidins are an important family of antimicrobial peptides involved in the innate immune system and have been discovered quite recently in teleost. Differently from the well-studied mammal cathelicidins, information about their structural and functional characteristics and the tissue expression and localization are yet scattered or inconsistent in fish and in particular in salmonids. The present work highlights some characteristics of salmonid cathelicidins. Results indicate that fragments of the C-terminal domain own a wide-spectrum, salt-sensitive antibacterial activity es

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SALVATI, ELISA. "Multi-functionalized nanoparticles for therapy and diagnosis of alzheimer's disease." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/43984.

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Alzheimer Disease (AD) is the most common form of dementia among the older people and as the population ages, it is estimated to triplicate by 2040. Since an effective therapy and early diagnosis are not available at the date there is an urgent need to develop new methods and tools to treat this huge disease. The abnormal deposition of amyloid-beta peptides (Aβ) on brain tissues is one of the main neuropathological features of AD. Therefore, targeting of cerebral Aβ has been suggested for therapeutic and/or diagnostic purposes for the pathology. One of the main obstacle in the treatment of CNS

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Javor, Sacha. "Peptide dendrimers as enzyme mimics /." [S.l.] : [s.n.], 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000277027.

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Chen, Fei, and 陳飛. "Studies on aminoxy peptides and prebiotic peptide formation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38534149.

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Metzger, Sabine. "Massenspektrometrische Analytik komplexer Peptidgemische." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963444298.

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Hanay, Christiane. "Optimierung von Kupplungsverfahren für die Peptidsegmentkondensation." [S.l. : s.n.], 1998. http://deposit.ddb.de/cgi-bin/dokserv?idn=955351499.

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