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Relevant bibliographies by topics / Bioactive Heterocycles / Dissertations / Theses

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Dissertations / Theses on the topic 'Bioactive Heterocycles'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Agocs, Lisa Lynn. "Design of bioactive chalcogenobismuth(III) heterocycles." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24728.pdf.

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2

Rai, B. "Synthesis of some bioactive oxygen and nitrogen heterocycles." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1993. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3080.

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3

Trippier, Paul Charles. "Synthesis of highly substituted heterocycles : the oxazolomycins." Thesis, University of Oxford, 2006. http://ora.ox.ac.uk/objects/uuid:b758987c-7a0c-4c1b-982c-61b4d383680a.

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This thesis is concerned with studies towards the total synthesis of a class of natural products - the oxazolomycins. Attention was focused on the left-hand side triene fragment and right-hand side lactam heterocyclic system. This thesis describes the synthesis of a racemic terminal phenyl analogue of oxazolomycin A and C, possessing the left-hand side triene geometry as required. A novel truncated pyridine analogue is also described. The molecules represent a racemic total synthesis of analogues of phthoxazolin A and inthomycins B and C. The synthesis is based upon a crucial Stille cross-coup

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4

Deshpande, S. R. "Synthetic studies in bioactive nitrogen, oxygen and sulfur heterocycles." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1991. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2997.

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5

Shabbir, Ghulam. "The synthesis and mechanism of formation of some bioactive heterocycles." Thesis, University of Hertfordshire, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365934.

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6

Kilburn, John Paul. "Novel solid-phase synthesis strategies for the preparation of heterocycles and guanidines." Thesis, Open University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247056.

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7

Pfeifer, Viktor. "Tritium and Deuterium Labelling of Bioactive Molecules Catalyzed by Metallic Nanoparticles." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS275/document.

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Cette thèse vise à développer de nouvelles méthodes efficaces pour incorporer des isotopes de l’hydrogène dans les molécules organiques complexes, après une introduction portant sur les applications et la synthèse des molécules marquées par le deutérium et tritium. Les méthodes permettant le marquage, par échange isotopique direct, d’hétérocycles azotés par des isotopes de l’hydrogène restent perfectibles, voire inexistantes dans certains cas, malgré la récurrence de ce type de sous-structures dans les molécules d’intérêt pharmacologique. Pour cette raison, la majeure partie de ce travail a co

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8

Mojally, Mariam. "DNA binding studies of fluorinated bioactive heterocyclic compounds." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/16732.

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Fluorinated heterocyclic compounds have drug like properties and possess a valuable biological activity due to their rigid chemical structures and the high solubility profile. Novel fluorinated heteroarenes have been synthesised by SNAr reaction of a range of fluorinated arenes including pentafluoropyridine, hexafluorobenzene and pentafluorotoluene to introduce a range of groups specially nitriles, benzimidazole, carbazole and benzimidazole. A number of cyclization reactions have been investigated with the aim of forming polycyclic structures that could act as DNA intercalators. The synthesise

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9

Dey, Sourav. "Synthesis of bioactive organic heterocyclic compounds using novel catalysts." Thesis, University of North Bengal, 2022. http://ir.nbu.ac.in/handle/123456789/5160.

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10

Chan, Lai Chun. "Synthesis of novel heterocyclic constraints as probes for peptide bioactive conformation." Thesis, University of Bath, 1992. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303487.

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11

Mitra, Bijeta. "Development of new protocols towards construction of bioactive hetero cyclic compounds." Thesis, University of North Bengal, 2021. http://ir.nbu.ac.in/handle/123456789/4368.

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12

Ciaglia, Tania. "Design and synthesis of bioactive small molecules by traditional and innovative methods." Doctoral thesis, Universita degli studi di Salerno, 2018. http://hdl.handle.net/10556/3188.

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2016 - 2017<br>My PhD research plan concerns the exploration of the structural requirements determining TRPM8 modulation. We prepared a series of N-substituted tryptamines and identified two compounds acting, respectively, as an activator (21) or an inhibitor (12) of calcium influx in HEK293 cells. To develop more potent and selective derivatives we designed and synthetized new series of potential tetrahydroisoquinoline- and tetrahydro-β-carboline-based TRPM8 modulators. The synthetic approach used for the preparation of these compounds led to indole-fused aminoacetal derivatives. Optimization

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13

Ferrazzano, Lucia <1989&gt. "Five-Membered Nitrogen Heterocycle Derivatives as Core Structures for the Synthesis of Bioactive Compounds Classes." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amsdottorato.unibo.it/7956/1/PhD%20thesis%20Lucia%20Ferrazzano%20AMS%20dottorato.pdf.

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The research towards new cyclic isosteres of functional groups and the optimization of their synthesis have been one of the basis of this work. In particular, the attention was paid to three different heterocycles: isoxazolines, isoxazolidinones and 3,4-dehydro-beta-prolines. The synthetic protocols developed for them are based on the electrophylic properties of alkylidene acetoacetates, malonates, acetoacetamide esters and malonamides. Their preparation is found on Knöevenagel condensation and a microwaves-assisted protocol.For this last topic, two applications are microwave-assisted protocol

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14

Maddirala, Amarendar Reddy. "Applications of Ugi Four Component Cascade Coupling Reactions for the Synthesis of Bioactive Diverse Heterocyclic Molecules and Natural Products." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1461775415.

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15

Reddi, R. N. "Enantioselective synthesis of bioactive molecules and development of synthetic methodologies involving n-heterocyclic carbene and iodine catalysis of alkenes and aldehydes." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2015. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2112.

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16

Meyer, Maxime. "Conception et synthèse de nouvelles molécules bioactives duales : vers des composés antagonistes AT1 et agonistes PPAR[gamma]." Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0221.

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Certains antagonistes du récepteur AT1 (« angiotensin II type 1 receptors ») utilisés dans le traitement de l'hypertension artérielle ont par la suite également montré une activité au niveau de PPAR[gamma] (« Peroxisome Proliferator Activated Receptor [gamma] »), un récepteur impliqué dans la régulation du métabolisme du glucose. Cela constitue une nouvelle approche thérapeutique vers un traitement concomitant de l'hypertension artérielle et du diabète de type II, qui sont souvent associés. Dans ce contexte, nous nous sommes dirigés vers la conception rationnelle de molécules capables d'intera

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17

謝麗玉. "Synthesis of Diketopiperazine Containing Heterocycles Potentially Useful as Bioactive Agents." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/23298569096872739998.

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碩士<br>國立中正大學<br>化學研究所<br>92<br>Many biologically active natural products possess the structure of diketopiperazine. In principle, the construction of diketopiperazine functional groups can be readily achieved using standard peptide chemistry. To expand the molecular diversity, the technology of combinatorial organic synthesis on solid support was employed in the preparation of diketopiperazine libraries. In our study, the Pictet-Spengler reaction was first utilized in the condensations of various aldehydes with the tryptophan-loaded Wang resin to give the desired diasteromeric tetrahydro--

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18

Hyland, IKP. "Synthesis and functionalisation of heterocyclic molecules with bioactive properties." Thesis, 2020. https://eprints.utas.edu.au/35032/1/Hyland_whole_thesis.pdf.

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Heterocycles are one of the most important class of molecules in medicinal chemistry. These compounds comprise a vast amount of the bioactive molecules available and provide biological activity over a huge range of targets. This work strives to develop novel drug candidates to target different diseases, utilising structure-activity relationship data and the results of biological testing to guide synthesis. The ultimate aim is to discover lead drug candidates that could advance to clinical trials and are readily accessible. Part One of this thesis discusses the synthesis of thiophenes and prel

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19

Manoj and 馬諾勁. "EXPLORATION OF NITROALKENES TOWARDS THE SYNTHESIS OF BIOACTIVE O, N-HETEROCYCLES." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/37438201511724116630.

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博士<br>國立臺灣師範大學<br>化學系<br>102<br>The development of novel and efficient protocols for the synthesis of O, N -containing heterocyclic compounds is an important area of research in synthetic chemistry due to their versatile biological utility and potential application in medicinal as well as pharmaceutical chemistry. In this regards, we have utilized cheap and readily available starting material such as nitroalkenes for the synthesis of O, N- heterocycles. The content of this dissertation is divided into five chapters, the Chapter-I deals with overview on the synthesis and utility of nitroalkene

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20

Krishnan, Anand. "Synthesis of Bioactive Nitrogen Heterocycles and Functionalized Nanomaterials for Biological and Catalytic Applications." Thesis, 2015. http://hdl.handle.net/10321/1181.

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Submitted in fulfillment of the requirements of the Degree of Doctor of Technology: Chemistry,Durban University of Technology, 2014.<br>Aromatic heterocycles are highly important structural units found in a large number of biologically active natural compounds, pharmaceuticals and catalytic compounds. They have a crucial role in organic syntheses, which results in the generation of high value products. Among heterocycles, those containing nitrogen are the most indispensable structural motifs and are widely used against dreaded diseases such as Malaria, TB, HIV/AIDS and Cancer. The inclusion of

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21

Tudu, P. "Report of dioxidovanadium complexes of bioactive heterocycles: synthesis, characterization and study of biological activity." Thesis, 2014. http://ethesis.nitrkl.ac.in/6021/1/E-174.pdf.

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A series of new dioxidovanadium(V) complexes [VO2L1-4] (1-4) have been reported. The complexes are obtained from the reaction of the HL1-4 with VO(acac)2 in 1:1 molar ratio in different solvent medium. All the synthesized ligands and the metal complex are successfully characterized by elemental analysis, IR and UV-vis spectroscopy. From various studies it is indicated that all the complexes possess square pyramidal structure.

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22

Upadhyay, Nitinkumar Satyadev, and 尼堤. "Rhodium (III)–Catalyzed Aerobic Oxidative C‒H Activation towards N-Heterocycles and relevant Bioactive Molecules." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/w5f7gy.

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博士<br>國立清華大學<br>化學系所<br>105<br>In recent year transition-metal-catalyzed C‒H activation reaction got considerable attention because of catalytic reaction does not require pre-functionalization also desired product is highly regioselective and utility of reaction can be applicable to synthesis biologically important compounds in one pot operation with high atom-efficacy. In this thesis, aerobic rhodium–catalyzed inter and intra molecular C‒H Bond functionalization reactions are described. For better understanding, I divided this thesis into three chapters. The first chapter describe about rhodi

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23

Ko, Shengkai, and 柯勝凱. "The improvement in the synthesis of bioactive heterocyclic molecules." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/98986374395793866898.

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博士<br>國立臺灣師範大學<br>化學系<br>96<br>Part one CAN (cerium ammonium nitrate) and iodine can catalyze the reactions of indole or 1-methylindole with ,-unsaturated ketone or aldehyde in DMSO/H2O (5 : 1) or ether solution at room temperature to obtain moderate to high yields of different products. The result was proposed to proceed through the 1,4-addition first to obtain intermedium and then intermedium can react with excess indole continuously to undergo the 1,2-addition to generate final triindolyl compounds. Part Two A one-pot condensation of -naphthol with aldehydes in the presence of Amberlyst

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24

Frija, L. "Investigation of structural effects on the reactivity of heterocyclic bioactive compounds." Doctoral thesis, 2008. http://hdl.handle.net/10400.1/856.

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Tese de dout., Química, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2008<br>In the course of this investigation, structural effects on the reactivity of a series of heterocyclic compounds, in particular tetrazole and benzisothiazole derivatives, submitted to different chemical environments, were explored. The photochemistry of several representative tetrazoles was considered in solution and for the compounds trapped in a rigid matrix of solidified argon at cryogenic temperatures. UV-excitation resulted in photofragmentation of tetrazoles with a wide range of exit channel

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25

Pinto, Patrícia Alexandra Soares. "Synthesis of bioactive chalcones aond their heterocyclic derivatives as potential antitumor agents." Master's thesis, 2016. http://hdl.handle.net/10316/36300.

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26

Carvalho, Maria Solange Dantas de. "New heterocyclic bioactive fluorescent compounds: spectroscopic studies of DNA interactions and encapsulation in nanoliposomes." Doctoral thesis, 2013. http://hdl.handle.net/1822/25580.

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Tese de doutoramento em Ciências (área de especialização em Química)<br>Spectroscopic studies (absorption and steady-state fluorescence) of potential antitumoral heteroaryl and heteroannulated indoles, benzothienopyran-1-ones, methyl 3-amino-6-heteroarylthieno[3,2-b]pyridine-2-carboxylates, tetracyclic thieno[3,2-b]pyridine derivatives and benzothienoquinolines, synthesized in our research group, were performed in solvent of different polarities. Generally, all the compounds presented a solvent sensitive emission with significant red-shifts in polar solvents, pointing out for their poten

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