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Journal articles on the topic 'Bioavailability'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Stielow, Marlena, Adrianna Witczyńska, Natalia Kubryń, Łukasz Fijałkowski, Jacek Nowaczyk, and Alicja Nowaczyk. "The Bioavailability of Drugs—The Current State of Knowledge." Molecules 28, no. 24 (2023): 8038. http://dx.doi.org/10.3390/molecules28248038.

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Drug bioavailability is a crucial aspect of pharmacology, affecting the effectiveness of drug therapy. Understanding how drugs are absorbed, distributed, metabolized, and eliminated in patients’ bodies is essential to ensure proper and safe treatment. This publication aims to highlight the relevance of drug bioavailability research and its importance in therapy. In addition to biochemical activity, bioavailability also plays a critical role in achieving the desired therapeutic effects. This may seem obvious, but it is worth noting that a drug can only produce the expected effect if the proper

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2

HOLLMAN, PETER C. H. "Bioavailability." Nutrition Today 35, no. 5 (2000): 187–90. http://dx.doi.org/10.1097/00017285-200009000-00006.

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3

ANB, Singab. "Bioavailability of Natural Products." Bioequivalence & Bioavailability International Journal 3, no. 1 (2019): 1–2. http://dx.doi.org/10.23880/beba-16000137.

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4

Thilakarathna, Surangi, and H. Rupasinghe. "Flavonoid Bioavailability and Attempts for Bioavailability Enhancement." Nutrients 5, no. 9 (2013): 3367–87. http://dx.doi.org/10.3390/nu5093367.

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5

Rick Mullin. "Confronting bioavailability." C&EN Global Enterprise 100, no. 34 (2022): 17–21. http://dx.doi.org/10.1021/cen-10034-feature1.

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6

Hassan, M., P. Ljungman, P. Bolme, et al. "Busulfan bioavailability." Blood 84, no. 7 (1994): 2144–50. http://dx.doi.org/10.1182/blood.v84.7.2144.2144.

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Abstract Busulfan is widely used as a component of the myeloablative therapy in bone marrow transplantation. Recent studies have shown that the drug disposition is altered in children and is associated with less therapeutic effectiveness, lower toxicities, and higher rates of engraftment failure. We have evaluated the bioavailability of the drug in two groups of patients: eight children between 1.5 and 6 years of age and eight older children and adults between 13 and 60 years. Oral bioavailability showed a large interindividual variation. In children, the bioavailability ranged from 0.22 to 1.

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7

Hassan, M., P. Ljungman, P. Bolme, et al. "Busulfan bioavailability." Blood 84, no. 7 (1994): 2144–50. http://dx.doi.org/10.1182/blood.v84.7.2144.bloodjournal8472144.

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Busulfan is widely used as a component of the myeloablative therapy in bone marrow transplantation. Recent studies have shown that the drug disposition is altered in children and is associated with less therapeutic effectiveness, lower toxicities, and higher rates of engraftment failure. We have evaluated the bioavailability of the drug in two groups of patients: eight children between 1.5 and 6 years of age and eight older children and adults between 13 and 60 years. Oral bioavailability showed a large interindividual variation. In children, the bioavailability ranged from 0.22 to 1.20, and f

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8

Peck, Brian. "Calcium Bioavailability." American Journal of Therapeutics 6, no. 6 (1999): 323–24. http://dx.doi.org/10.1097/00045391-199911000-00006.

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9

Englyst, Klaus N., and Hans N. Englyst. "Carbohydrate bioavailability." British Journal of Nutrition 94, no. 1 (2005): 1–11. http://dx.doi.org/10.1079/bjn20051457.

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There is consensus that carbohydrate foods, in the form of fruit, vegetables and whole-grain products, are beneficial to health. However, there are strong indications that highly processed, fibre-depleted, and consequently rapidly digestible, energy-dense carbohydrate food products can lead to over-consumption and obesity-related diseases. Greater attention needs to be given to carbohydrate bioavailability, which is determined by the chemical identity and physical form of food. The objective of the present concept article is to provide a rational basis for the nutritional characterisation of d

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10

McNulty, Helene, and Kristina Pentieva. "Folate bioavailability." Proceedings of the Nutrition Society 63, no. 4 (2004): 529–36. http://dx.doi.org/10.1079/pns2004383.

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The achievement of optimal folate status to prevent neural-tube defects, and possibly other diseases, is hindered by the well-recognised incomplete bioavailability of the natural folates found in foods compared with the synthetic vitamin, folic acid. Folate bioavailability from different foods is considered to be dependent on a number of factors, including the food matrix, the intestinal deconjugation of polyglutamyl folates, the instability of certain labile folates during digestion and the presence of certain dietary constituents that may enhance folate stability during digestion. There is c

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11

Davidsson, Lena. "Bioavailability 2001." European Food Research and Technology 214, no. 1 (2002): 2. http://dx.doi.org/10.1007/s00217-001-0395-8.

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12

Hansen, Hanne Solheim, and Knut Hove. "Radiocesium Bioavailability." Health Physics 60, no. 5 (1991): 665–73. http://dx.doi.org/10.1097/00004032-199105000-00005.

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13

Farago, Peter. "Social bioavailability." Chemical Speciation & Bioavailability 2, no. 1 (1990): 2. http://dx.doi.org/10.1080/09542299.1990.11083121.

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14

Harvey, Linda. "Mineral bioavailability." Nutrition & Food Science 31, no. 4 (2001): 179–82. http://dx.doi.org/10.1108/00346650110392253.

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15

Vaishnavi Tejram Gabhane, Akanksha Ravindra Ashtankar, Swati Vinayak Dongre, Vaibhav P. Uplanchiwar, Vinod M. Thakare, and Abhishek Mohan Pimpale. "Bioavailability enhancement." World Journal of Advanced Research and Reviews 18, no. 2 (2023): 224–27. http://dx.doi.org/10.30574/wjarr.2023.18.2.0769.

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The rate and extent (amount) of unmodified medication absorption from its dose form is referred to as bioavailability. It is one of the critical criteria for achieving optimal medication concentration in the systemic circulation. Bioavailability is a significant factor of a drug's therapeutic efficacy, which is determined by the drug's solubility in gastro intestinal fluid. Poor water solubility, sluggish dissolution rate, poor stability of dissolved drug at physiological pH, poor penetration through biological membrane, and extensive first pass metabolism are all signs of a medication with po

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16

Vaishnavi, Tejram Gabhane, Ravindra Ashtankar Akanksha, Vinayak Dongre Swati, P. Uplanchiwar Vaibhav, M. Thakare Vinod, and Mohan Pimpale Abhishek. "Bioavailability enhancement." World Journal of Advanced Research and Reviews 18, no. 2 (2023): 224–27. https://doi.org/10.5281/zenodo.8379708.

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The rate and extent (amount) of unmodified medication absorption from its dose form is referred to as bioavailability. It is one of the critical criteria for achieving optimal medication concentration in the systemic circulation. Bioavailability is a significant factor of a drug's therapeutic efficacy, which is determined by the drug's solubility in gastro intestinal fluid. Poor water solubility, sluggish dissolution rate, poor stability of dissolved drug at physiological pH, poor penetration through biological membrane, and extensive first pass metabolism are all signs of a medication

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17

Wood, John H. "Controlled Drug Bioavailability, vol. 2: Bioavailability Methodology and Regulation." Journal of Pharmaceutical Sciences 74, no. 7 (1985): 801. http://dx.doi.org/10.1002/jps.2600740736.

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18

Hikon, Baba Nwunuji, and Garbunga Gary Yebpella. "Bioavailability of Metals in the Biosphere." Trends in Ecological and Indoor Environmental Engineering 2, no. 1 (2024): 41–49. http://dx.doi.org/10.62622/teiee.024.2.1.41-49.

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In some areas, soil, sediment, water, and organic materials may exhibit elevated concentrations of various metals. Under certain conditions, these metals can take on most bioavailable forms. To assess the impacts and potential risks associated with elevated element concentrations, understanding the fraction of whole elements in water, sediment, and soil which are bioavailable is very important. The study aims to examine these conditions to accurately assess potential environmental impacts. For the study, searches were carried out using the keywords "bioavailability", "metal" and "environment"

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19

M, Vidhya. "Bioavailability – Challenges and Advances in Drug Targeting." Bioequivalence & Bioavailability International Journal 7, no. 1 (2023): 1–3. http://dx.doi.org/10.23880/beba-16000186.

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It has been a very challenging task in drug development to handle bioavailability of drug molecules during targeting. Foremost challenges include the time span involved apart from various complexities, wrong methods or failure in outcome, increasing manual and financial requirements to be managed in the drug discovery process. Among this bioavailability is one of the biggest challenges handled to successfully identify druggability in a molecule. Various methods of administration and targeting has been used including co-crystallization, micro emulsion, micellar solubilization and other traditio

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20

Kaşıkcı, Müzeyyen, and Neriman Bağdatlıoğlu. "Bioavailability of Quercetin." Current Research in Nutrition and Food Science Journal 4, Special-Issue-October (2016): 146–51. http://dx.doi.org/10.12944/crnfsj.4.special-issue-october.20.

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Quercetin is generally present as quercetin glycoside in nature and involves quercetin aglycone conjugated to sugar moieties such as glucose or rutinose. Quercetin has been reported to exhibit antioxidative, anti-carcinogenic, anti-inflammatory, anti-aggregatory and vasodilating effects. Unfortunately, quercetin bioavailability is generally poor and several factors affect its bioavailability. Quercetin bioavailability varies widely between individuals. Gender may affect quercetin bioavailability, but there is no clear evidence. There has been little research looking for the effects of age and

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21

Sies, H., and W. Stahl. "BIOAVAILABILITY OF LYCOPENE." Acta Horticulturae, no. 487 (March 1999): 389–94. http://dx.doi.org/10.17660/actahortic.1999.487.63.

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22

MAYERSOHN, M. "Vitamin C Bioavailability." Journal of Nutritional Science and Vitaminology 38, Special (1992): 446–49. http://dx.doi.org/10.3177/jnsv.38.special_446.

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23

Fang, Jim. "Bioavailability of anthocyanins." Drug Metabolism Reviews 46, no. 4 (2014): 508–20. http://dx.doi.org/10.3109/03602532.2014.978080.

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24

Ohrvik, Veronica E., and Cornelia M. Witthoft. "Human Folate Bioavailability." Nutrients 3, no. 4 (2011): 475–90. http://dx.doi.org/10.3390/nu3040475.

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25

Lipworth, B. J., and A. Grove. "Bioavailability of salbutamol." Thorax 49, no. 11 (1994): 1183. http://dx.doi.org/10.1136/thx.49.11.1183.

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26

Lönnerdal, B. "Bioavailability of copper." American Journal of Clinical Nutrition 63, no. 5 (1996): 821S—829S. http://dx.doi.org/10.1093/ajcn/63.5.821.

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27

Traber, Maret G. "The bioavailability bugaboo." American Journal of Clinical Nutrition 71, no. 5 (2000): 1029–30. http://dx.doi.org/10.1093/ajcn/71.5.1029.

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28

Marquenie, J. M. "Bioavailability of micropollutants." Environmental Technology Letters 6, no. 1-11 (1985): 351–58. http://dx.doi.org/10.1080/09593338509384352.

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29

Hendrich, Suzanne. "Bioavailability of isoflavones." Journal of Chromatography B 777, no. 1-2 (2002): 203–10. http://dx.doi.org/10.1016/s1570-0232(02)00347-1.

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30

Stahl, W. "Bioavailability and metabolism." Molecular Aspects of Medicine 23, no. 1-3 (2002): 39–100. http://dx.doi.org/10.1016/s0098-2997(02)00016-x.

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31

Rojpibulstit, Malee, Srirat Kasiwong, Siwasak Juthong, Narubodee Phadoongsombat, and Damrongsak Faroongsarng. "Ambroxol Lozenge Bioavailability." Clinical Drug Investigation 23, no. 4 (2003): 273–80. http://dx.doi.org/10.2165/00044011-200323040-00007.

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32

Faroongsarng, Damrongsak, Malee Rojpibulstit, Srirat Kasiwong, and Narubodee Phadoongsombat. "Ambroxol Lozenge Bioavailability." Clinical Drug Investigation 24, no. 11 (2004): 681–88. http://dx.doi.org/10.2165/00044011-200424110-00007.

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33

Martin, Yvonne C. "A Bioavailability Score." Journal of Medicinal Chemistry 48, no. 9 (2005): 3164–70. http://dx.doi.org/10.1021/jm0492002.

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34

Butterworth, KennethR, PhilipN Drewitt, ChristineD Springall, StephenR Moorhouse, Michael Young, and J. T. Hughes. "Bioavailability of aluminium." Lancet 339, no. 8807 (1992): 1489. http://dx.doi.org/10.1016/0140-6736(92)92094-v.

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35

Mendelson, John, Reese T. Jones, Robert Upton, Peyton Jacob, and E. Thomas Everhart. "Sublingual Buprenorphine Bioavailability." Clinical Pharmacology & Therapeutics 59, no. 2 (1996): 209. http://dx.doi.org/10.1038/sj.clpt.1996.337.

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36

Walle, Thomas. "Bioavailability of resveratrol." Annals of the New York Academy of Sciences 1215, no. 1 (2011): 9–15. http://dx.doi.org/10.1111/j.1749-6632.2010.05842.x.

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37

Castenmiller, J. J. M., and C. E. West. "Bioavailability of carotenoids." Pure and Applied Chemistry 69, no. 10 (1997): 2145–50. http://dx.doi.org/10.1351/pac199769102145.

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38

Delaney, T. P. "Bioavailability of drugs." BMJ 292, no. 6517 (1986): 411. http://dx.doi.org/10.1136/bmj.292.6517.411-a.

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39

Grove, Mette, Anette Müllertz, Jeanet Løgsted Nielsen, and Gitte Pommergaard Pedersen. "Bioavailability of seocalcitol." European Journal of Pharmaceutical Sciences 28, no. 3 (2006): 233–42. http://dx.doi.org/10.1016/j.ejps.2006.02.005.

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40

Grove, Mette, Anette Müllertz, Gitte P. Pedersen, and Jeanet L. Nielsen. "Bioavailability of seocalcitol." European Journal of Pharmaceutical Sciences 31, no. 1 (2007): 8–15. http://dx.doi.org/10.1016/j.ejps.2007.01.007.

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41

Woodcock, B. G., G. Menke, and N. Rietbrock. "Nitroplasters and bioavailability." Trends in Pharmacological Sciences 7 (January 1986): 338–40. http://dx.doi.org/10.1016/0165-6147(86)90378-0.

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42

SHU, H., P. TEITELBAUM, A. S. EBB, et al. "Bioavailability of Soil-Bound TCDD: Dermal Bioavailability in the Rat." Toxicological Sciences 10, no. 2 (1988): 335–43. http://dx.doi.org/10.1093/toxsci/10.2.335.

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43

SHU, H., D. PAUSTENBACH, F. J. MURRAY, et al. "Bioavailability of Soil-Bound TCDD: Oral Bioavailability in the Rat." Toxicological Sciences 10, no. 4 (1988): 648–54. http://dx.doi.org/10.1093/toxsci/10.4.648.

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44

SHU, H. "Bioavailability of soil-bound TCDD: Oral bioavailability in the rat." Fundamental and Applied Toxicology 10, no. 4 (1988): 648–54. http://dx.doi.org/10.1016/0272-0590(88)90191-1.

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45

SHU, H. "Bioavailability of soil-bound TCDD: Dermal bioavailability in the rat." Fundamental and Applied Toxicology 10, no. 2 (1988): 335–43. http://dx.doi.org/10.1016/0272-0590(88)90319-3.

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46

Arumugam, Arjun, Geetha Lakshmi, Srinivas G, et al. "Bioequivalence of Two Perampanel 12mg Tablets in Healthy, Adult, Human Subjects under Fed Conditions - An Open Label, Cross Over Study." JSM Bioavailability and Bioequivalence 3, no. 1 (2023): 1–6. http://dx.doi.org/10.47739/2641-7812.bioavailability.1009.

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Background: Perampanel is a glutamate non-competitive receptor antagonist that is effective as adjunctive therapy for epilepsy. The main objective of the present research is to compare the bioavailability and to evaluate the bioequivalence between the test and reference product. The secondary objective is to assess the safety and tolerability of the drug

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47

Segarra-Newnham, Marisel. "Book Review: Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability." Annals of Pharmacotherapy 38, no. 5 (2004): 907. http://dx.doi.org/10.1345/aph.1d557.

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48

Dressman, Jennifer. "Review of Drug Bioavailability. Estimation of Solubility, Permeability, Absorption and Bioavailability." Journal of Controlled Release 96, no. 3 (2004): 510–11. http://dx.doi.org/10.1016/j.jconrel.2004.02.005.

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49

Welshman, Ian R., Theresa A. Sisson, Gail L. Jungbluth, Dennis J. Stalker, and Nancy K. Hopkins. "Linezolid absolute bioavailability and the effect of food on oral bioavailability." Biopharmaceutics & Drug Disposition 22, no. 3 (2001): 91–97. http://dx.doi.org/10.1002/bdd.255.

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50

Kowalczyk, Magdalena, Agata Znamirowska-Piotrowska, Magdalena Buniowska-Olejnik, Grzegorz Zaguła, and Małgorzata Pawlos. "Bioavailability of Macroelements from Synbiotic Sheep’s Milk Ice Cream." Nutrients 15, no. 14 (2023): 3230. http://dx.doi.org/10.3390/nu15143230.

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To determine the potential bioavailability of macroelements (Ca, Mg, P, K), probiotic ice cream samples (Lactaseibacillus paracasei L-26, Lactobacillus casei 431, Lactobacillus acidophilus LA-5, Lactaseibacillus rhamnosus and Bifidobacterium animalis ssp. lactis BB-12) from sheep’s milk with inulin, apple fiber and inulin, or apple fiber and control samples were submitted to in vitro digestion in the mouth, stomach and small intestine. The bioavailability of calcium in the ice cream samples ranged from 40.63% to 54.40%, whereas that of magnesium was 55.64% to 44.42%. The highest bioavailabilit

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