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Relevant bibliographies by topics / Biological active compound

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Academic literature on the topic 'Biological active compound'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Biological active compound"

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Ježek, Jan, Milan Zaoral, Miloš Buděšínský, Jiří Günther, and Jiří Rotta. "Muramyl-dipeptide analogues: Synthesis and biological activities." Collection of Czechoslovak Chemical Communications 53, no. 11 (1988): 2897–906. http://dx.doi.org/10.1135/cccc19882897.

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In the search for immunoadjuvant active compounds without pyrogenic activity we prepared N-Ac-norMur-L-Abu-D-Gln-O-Bu (V), N-Ac-Mur-L-Abu-D-Gln-O-Bu (VII) and their respective α-benzylglycosides VI and VIII. All the prepared compounds are nonpyrogenic. In the delayed hypersensitivity test, compound V is inactive, VI is comparable to MDP, VII is more and VIII is less active than MDP.

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Kumar, Navneet, Anjali Chauhan, Anuj, and Prachi. "Green and Benign Strategies for Synthesis of Biologically Active Compounds using Lipase as Biocatalyst." Bulletin of Pure and Applied Sciences-Chemistry 42, no. 1 (2023): 33–40. http://dx.doi.org/10.48165/bpas.2023.42c.1.6.

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An efficient, feasible, mild, affordable, and environmentally friendly method has been developed for the synthesis of biologically active compound 3-methylene-indoline-2-one from Isatin and active methylene compounds using Lipase as a Green and Biocatalyst. Biological Processes are very important to optimization to increase and improve the efficiency of cost. In this project, Malononitrile, or Dimedone reacts with Isatin in presence of lipase. The essential features of this approach are metal-free reaction, high yield, nontoxic, and less hazardous. These reactions surpass metal-catalyzed proce

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Appell, Kenneth C., Thomas D. Y. Chung, Michael J. H. Ohlmeyer, Nolan H. Sigal, John J. Baldwin, and Daniel Chelsky. "Biological Screening of a Large Combinatorial Library." Journal of Biomolecular Screening 1, no. 1 (1996): 27–31. http://dx.doi.org/10.1177/108705719600100111.

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Encoding technology has allowed for the creation of libraries of 50,000 or more low-molecular-weight compounds for biological testing. The current challenge is to properly and efficiently screen among these compounds for useful biological activities. In this example, actives against two related G-protein coupled receptors were sought from a combinatorial library of 56,000 members. The library was synthesized on solid phase using the split synthesis method and photochemically released for testing. At a screening concentration of 0.5-1 /LM, 86 unique structures were identified as active against

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Simonetti, Giorgia, Carla Boga, Joseph Durante, et al. "Synthesis of Novel Tryptamine Derivatives and Their Biological Activity as Antitumor Agents." Molecules 26, no. 3 (2021): 683. http://dx.doi.org/10.3390/molecules26030683.

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We synthesized five novel tryptamine derivatives characterized by the presence of an azelayl chain or of a 1,1,1-trichloroethyl group, in turn connected to another heterocyclic scaffold. The combination of tryptamin-, 1,1,1-trichloroethyl- and 2-aminopyrimidinyl- moieties produced compound 9 identified as the most active compound in hematological cancer cell lines (IC50 = 0.57–65.32 μM). Moreover, keeping constant the presence of the tryptaminic scaffold and binding it to the azelayl moiety, the compounds maintain biological activity. Compound 13 is still active against hematological cancer ce

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Cowley, Phillip M., and David C. Rees. "Applications of Solid-Phase Synthesis to Drug Discovery." Current Medicinal Chemistry 4, no. 3 (1997): 211–27. http://dx.doi.org/10.2174/0929867304999220313112224.

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This review aims to highlight the opportunities for the utilisation of solid-phase synthesis in the process of drug discovery. The two main sections discuss the preparation and biological testing of compound libraries and the preparation of compound arrays based around approved drugs. Biologically active compounds in assays for enzyme inhibition, membrane bound protein ligands and intracellular hormone receptors are discussed, illustrating the power of this relatively new tool in the arena of medicinal chemistry.

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Patel, Rajat, Puja Sharma, Rohit R. Koshti, Akshay Vyas, and Chetan B. Sangani. "Synthesis, Biological Evaluation, DFT Studies and Molecular Docking of Novel 4-(5-(1H-Imidazol-1-yl)-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-amino-3-methyl- 1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile and its Derivatives." Asian Journal of Chemistry 35, no. 7 (2023): 1616–24. http://dx.doi.org/10.14233/ajchem.2023.27921.

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A novel series consisting of eight imidazol-pyrazole hybrids ( 9a-h) are synthesized using a base catalyzed one pot multi-component reaction (MCR) and screened for in vitro biological activities. All compounds were found to display high biological activities but compound 9g was found to be the most active against EGFR (IC50 of 0.11 ± 0.02 μm), A549 and HepG2, while compound 9h was found to be most active against FabH (IC50 of 2.6 μm) E. coli. The DFT studies and molecular docking was done for compounds 9a-h to calculate the distance and angle between the active parts of the molecules and charg

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Khan, Khalid M., Zafar S. Saifyb, Abdullah Khan, et al. "Syntheses of Selected Quaternary Phenacylbromopyridinium Compounds and their Biological Evaluation." Zeitschrift für Naturforschung B 54, no. 9 (1999): 1210–18. http://dx.doi.org/10.1515/znb-1999-0920.

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The studies, presented here, deal with the synthetic modification of 5-bromonicotinic acid on its nitrogen nucleus. The synthetic transformations were carried out by reacting equimolar amounts of 5-bromonicotinic acid and phenacyl halides in acetone. A range of phenacyl halides were used with the objective of getting a variety of quaternary ammonium salts of 5- bromonicotinic acid derivatives as multipurpose biologically active compounds. Twelve quaternary ammonium salts of 5-bromonicotinic acid have been synthesized and tested for cytotoxicity, antibacterial and antifungal activities. These c

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Kadomtseva, Alena V., Georgy M. Mochalov, Maria A. Zasovskaya, and Anatoly M. Ob’edkov. "Synthesis, Structure, and Biological Activity of the Germanium Dioxide Complex Compound with 2-Amino-3-Hydroxybutanoic Acid." Inorganics 12, no. 3 (2024): 83. http://dx.doi.org/10.3390/inorganics12030083.

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Currently, a promising direction of study is the use of biologically active coordination compounds in the pharmacopoeia and the creation of effective bactericidal drugs, biomaterials, and enzyme modulators on that basis. The paper considers a coordination germanium compound with 2-amino-3-hydroxybutanoic acid. The prospects for the use of the compound in medicine are outlined. This work is aimed at solving the problems regarding the synthesis of biologically active compounds with a wide spectrum of actions. The structure and composition of the coordination compound have been established throug

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Albien, Anna-Lena, and Timo D. Stark. "(Bio)active Compounds in Daisy Flower (Bellis perennis)." Molecules 28, no. 23 (2023): 7716. http://dx.doi.org/10.3390/molecules28237716.

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The common daisy (Bellis perennis) belongs to the family Asteraceae and, in recent years, some new research has been published on the bioactive compounds and biological activities of its extracts. In 2014, the knowledge was partially summarized, but several new studies have been published in the last nine years. In addition, the substances were tabularly consolidated to give a comprehensive overview of over 310 individual components, compound classes, and bioactivities, as well as their accurate plant organ origin. The latest results have shown that the plant has antioxidative, antimicrobial,

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Ruwizhi, Ngonidzashe, and Blessing Atim Aderibigbe. "Cinnamic Acid Derivatives and Their Biological Efficacy." International Journal of Molecular Sciences 21, no. 16 (2020): 5712. http://dx.doi.org/10.3390/ijms21165712.

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The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes and neurological disorders, among many, has been reported. Cinnamic acid is obtained from cinnamon bark. Its structure is composed of a benzene ring, an alkene double bond and an acrylic acid functional group making it possible to modify the aforementioned functionalities with a variety of compounds resulting in bioactive agents with enhanced efficacy. The nature of the substituents incorporated into cinnamic acid has been found to play a huge role in either enhancing or decreasing the biological ef

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Dissertations / Theses on the topic "Biological active compound"

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Esmati, Nasim. "Synthesis of Biologically Active Compounds via Multicomponent Reactions and Evaluation of Their Biological Activities." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1525897360405194.

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Omar, Muhammad Nor bin. "Synthesis of biologically active compounds." Thesis, Liverpool John Moores University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343121.

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Burnell, Erica Sinead. "Synthesis of biologically active compounds." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/synthesis-of-biologically-active-compounds(a009591b-d439-4ff7-9e6f-36199a33e7c8).html.

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Part 1 describes the synthesis of (2S,3S,4R,5R)-5-(6-(((7-bromo-2-(dimethylamino)-4-((3-methylisoxazol-5-yl)methoxy)benzo[d]oxazol-5-yl)methyl)amino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyltetrahydrofuran-2-carboxamide, a selective A3 adenosine receptor agonist, and one of a number of adenosine analogues designed by Muscagen Ltd. with the purpose of treating cardiac ischaemia. The target compound was derived from a condensation of the known modified adenosine, (3aS,4S,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-N,2,2-trimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carboxamide with 5-(aminomethyl)-7-bromo-N,

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Salunkhe, A. M. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1987. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3270.

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Dhokte, U. P. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1988. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3299.

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Naik, A. M. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1986. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3274.

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Khobragade, D. A. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2006. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2529.

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Kumar, A. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1989. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3326.

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Bhonsle, J. B. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1992. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3034.

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Vidyasagar, V. "Synthesis of biologically active compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1985. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3228.

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Books on the topic "Biological active compound"

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Whapham, C. A. Biologically active compounds in seaweed extracts. University of Portsmouth, School of Pharmacy & Biomedical Sciences, 1995.

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Yue, Wu. Biologically-active compounds in seaweed extracts. University of Portsmouth, School of Pharmacy and Biomedical Science, 1996.

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Mao, Justin Y. Synthetic approaches to syn-diol containing biologically active compounds. Brock University, Dept. of Chemistry, 2002.

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Kinghorn, A. Douglas, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, and Verena M. Dirsch, eds. Biologically Active Compounds of Malaysian Medicinal and Aromatic Plants. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-86378-3.

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K, Burger, ed. Biocoordination chemistry: Coordination equilibria in biologically active systems. E. Horwood, 1990.

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Sukhareva, N. N. Biologically active substances of protozoa. Kluwer Academic, 2002.

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1932-, Cutler Horace G., and Cutler Stephen J, eds. Biologically active natural products: Agrochemicals. CRC Press, 1999.

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1932-, Cutler Horace G., and Cutler Stephen J, eds. Biologically active natural products: Agrochemicals. CRC Press, 1999.

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9

Gašić, Olga. Biologically active compounds of plants in the Fruška Gora mountain. Matica srpska, Odeljenje za prirodne nauke, 1997.

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Seelig, Bruce Duane. Water resource impacts: From medicines and other biologically active substances. NDSU Extension service, 2005.

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Book chapters on the topic "Biological active compound"

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Khan, Ayub, and Harindri Chaudhary. "Asymptotic Stability Analysis for Chaotic Predator-Prey Model via Active Controlled Hybrid Compound Difference Synchronization Strategy." In Trends in Biomathematics: Stability and Oscillations in Environmental, Social, and Biological Models. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-12515-7_9.

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Szajdak, Lech Wojciech. "Introduction: Biologically Active Compounds." In Bioactive Compounds in Agricultural Soils. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-43107-9_1.

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Hiyama, Tamejiro, and Hisashi Yamamoto. "Biologically Active Organofluorine Compounds." In Organofluorine Compounds. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-662-04164-2_5.

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Moberg, William K., Gregory S. Basarab, John Cuomo, and Paul H. Liang. "Biologically Active Organosilicon Compounds." In ACS Symposium Series. American Chemical Society, 1987. http://dx.doi.org/10.1021/bk-1987-0355.ch026.

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Breydo, Leonid. "Boron, Biologically Active Compounds." In Encyclopedia of Metalloproteins. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-1533-6_483.

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Breydo, Leonid. "Arsenic, Biologically Active Compounds." In Encyclopedia of Metalloproteins. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-1533-6_484.

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Breydo, Leonid. "Selenium, Biologically Active Compounds." In Encyclopedia of Metalloproteins. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-1533-6_485.

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Breydo, Leonid. "Silicon, Biologically Active Compounds." In Encyclopedia of Metalloproteins. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-1533-6_486.

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Fox, P. F., T. Uniacke-Lowe, P. L. H. McSweeney, and J. A. O’Mahony. "Biologically Active Compounds in Milk." In Dairy Chemistry and Biochemistry. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-14892-2_11.

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Akhtar, Nosheen, Sunbal Khalil Chaudhari, Sohaib Arshad, Hira Fatima, Muhammad Shoaib Amjad, and Saboon. "Biological Activities and Nutritional Value of Physalis peruviana L." In Natural Bio-active Compounds. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-7154-7_21.

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Conference papers on the topic "Biological active compound"

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Marliyana, Soerya Dewi, Maulidan Firdaus, Muhamad Widyo Wartono, Diana Inas Utami, and Uly Wulan Apriani. "Evaluation of the Antibacterial Activity of Pinostrobin Derivative Compounds from Ethylation and Allylation Reactions." In 8th International Conference on Advanced Material for Better Future. Trans Tech Publications Ltd, 2025. https://doi.org/10.4028/p-s3ucax.

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Temu Kunci (Kaempferia pandurata Roxb.) is one of the plants from the Zingiberaceae family that contains secondary metabolites derived from flavonoids. Studies on the bioactivity of flavonoid compounds from this species have shown various biological activities such as antibacterial, antioxidant, antiviral, antitumor, antipyretic, anti-inflammatory, analgesic, and insecticidal properties. Pinostrobin (5-hydroxy-7-methoxy flavanone) (1) is the major flavonoid found in the rhizomes of this plant and has been successfully derivatized through ethylation and allylation reactions. Two compounds were

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Lyublinskii, E. Ya. "Copper-Based Antifouling Coatings with Controlled Efficiency." In CORROSION 1995. NACE International, 1995. https://doi.org/10.5006/c1995-95215.

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Abstract Copper and its compounds are the active ingredients most used in antifouling marine paints today. The efficiency of these antifouling coatings, however, is typically only 30 to 40 percent, and their useful life two years or less. By properly optimizing a thermal spray copper-bearing coating system, however, it is possible to create an antifouling coating with an efficiency of 80 to 90 percent and a useful life of up to twenty years. The antifouling properties of such a coating are a function of the type and concentration of copper compounds released at the surface. They are also a fun

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Khancheuski, M. А., S. R. Albasri, E. I. Kvasyuk, and A. G. Sysa. "SYNTHESIS OF S8-BENZYLGUANOSINE." In SAKHAROV READINGS 2022: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2022. http://dx.doi.org/10.46646/sakh-2022-1-219-223.

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The creation of new effective drugs is one of the priority areas in the modern pharmaceutical industry. The development of an innovative drug always begins with the search for a new biologically active compound, followed by confirmation of its effectiveness and safety. The paper describes methods for obtaining S8-benzylguanosine, which is a derivative of thioguanosine nitrogenous bases and nucleosides with a wide range of biological activity.

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BIKOVENS, Oskars, Jevgenija PONOMARENKO, Sarmite JANCEVA, Maris LAUBERTS, Laima VEVERE, and Galina TELYSHEVA. "DEVELOPMENT OF THE APPROACHES FOR COMPLEX UTILIZATION OF BROWN ALGAE (FUCUS VESICULOSUS) BIOMASS FOR THE OBTAINING OF VALUE-ADDED PRODUCTS." In RURAL DEVELOPMENT. Aleksandras Stulginskis University, 2018. http://dx.doi.org/10.15544/rd.2017.091.

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The seaweed collected after stranding on beaches of Latvia is underexploited natural resource, which has a potential as raw material for biologically active compound extraction for cosmetic and pharmacy and fertilizer in sustainable agriculture. The aim of the present study was development of the approach for the processing of brown alga Fucus vesiculosus biomass, collected from the Gulf of Riga. The thorough characterization of the chemical composition of Fucus vesiculosus has shown that it is a potential source for obtaining of nitrogen-containing fertilizers, and biologically active compoun

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Vladu, Alina, Emilia Visileanu, Alexandra Gabriela Ene, Madalina Georgiana Albu Kaya, Viviana Roman, and Carmen Gaidau. "Biological evaluation of antimicrobial treated textiles." In 16th International Conference on Applied Human Factors and Ergonomics (AHFE 2025). AHFE International, 2025. https://doi.org/10.54941/ahfe1006194.

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Textiles provide a suitable environment for the growth of microorganisms, including fungi and bacteria. Their presence can have detrimental effects on both the fabric and the user. These effects may include unpleasant odors, fabric discoloration, a higher risk of contamination, and a decline in the material's mechanical strength. The transmission of infections through textiles can be mitigated by using antimicrobial fabrics, which either eliminate pathogens on contact or inhibit their reproduction before they spread to another surface or individual. Antimicrobial textiles are created by applyi

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Ozhiganov, M. E., G. S. Fedoseev, M. G. Medvedev, et al. "HCN band strengths study in the interstellar ice analogues." In 51-st All-Russian with international participation student scientific conference "Physics of Space". Ural University Press, 2024. http://dx.doi.org/10.15826/b978-5-7996-3848-1.59.

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The orbital telescopes have significantly simplified searching of the molecules in the condensed phase with active vibrations in the infrared, particularly hydrogen cyanide (HCN). This compound is found in numerous astronomical environments and can be a precursor to biological species. In this study, we acquired spectra of condensed HCN in the mid-IR range into mixtures of H2O, CO2, CO, CH3OH and a mixture of H2O:NH3 at varying concentrations of HCN. We measured the band strengths of HCN in these mediums, which are crucial for quantitatively determining column density of HCN based on astronomi

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Živković, Marijana, Irena Novaković, Sandra Šegan, Neda Đorđević, and Dušan Sladić. "STEROIDAL THIOSEMICARBAZONES: DRUG-LIKENESS AND ANTIOXIDANT PROPERTIES." In 3rd International Symposium on Biotechnology. University of Kragujevac, Faculty of Agronomy in Čačak, 2025. https://doi.org/10.46793/sbt30.66mz.

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Thiosemicarbazones (TSCs) are well known for their diverse biological activities and wide-ranging applications. This study assessed the drug- likeness and antioxidant potential of previously synthesized steroidal TSCs with promising cytotoxicity. While all tested androstane TSCs are drug-like, they have poor water solubility, strong plasma protein binding ability, and low blood-brain barrier permeability. Mono-TSCs show better absorption parameters, but bis- TSCs are stronger antioxidants, with compound 4 being 4.5 times more active than ascorbic acid. All tested TSCs could be considered poten

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Ungur, Nicon, Aurelian Gulea, and Tatiana Erhan. "Synthesis and study of the same hydrazincarbothioamides as privilege pharmacophores in pharmacology." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab05.

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Hydrazinecarbothioamides represent a privileged class of pharmacophores in pharmacology, thanks to an impressive number of derivatives that exhibit outstanding antimicrobial, anticancer and antifungal properties [1]. The presence of electron donor atoms such as N(nitrogen) and S(sulfur) substantially widen the spectrum of use. In the framework of theoretical studies on the structure of biologically active compounds with valuable properties were highlighted following common structural elements such as substitution of a hydrogen atom from the nitrogen atom (N) with the benzene ring, the introduc

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Gobbi, Alberto, D. Poppinger, and B. Rohde. "Finding Biological Active Compounds in Large Databases;." In The 1st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02069.

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Faraj, Fadhil Lafta, Salih Mahdi Salman, and Tammar Hussein Ali. "New surface active and biological active compounds with heterocyclic core." In PROCEEDING OF THE 1ST INTERNATIONAL CONFERENCE ON ADVANCED RESEARCH IN PURE AND APPLIED SCIENCE (ICARPAS2021): Third Annual Conference of Al-Muthanna University/College of Science. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0093601.

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Reports on the topic "Biological active compound"

1

Yompakdee, Chulee, and Warintorn Chavasiri. An active compound Kempferia parviflora with inhibitory activity against GSK-3 kinase implicated in type II Diabetes and Alzheimer's disease. Chulalongkorn University, 2015. https://doi.org/10.58837/chula.res.2015.37.

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Calcium signaling pathways play pivotal roles in regulation of various important biological processes in eukaryotes ranging from yeast to human. Because of the high degree in gene conservation from yeast to human, the small molecule inhibitors discovered in the yeast based-drug screening system can be expected to exert their function in human as well. The immunosuppressive agents, FK506 and cyclosporine A, are an example. Our previous studies using a zds1 yeast-based assay to search for inhibitors in the calcium signaling pathway in Saccharomyces cerevisae mutant strain from the crude extract

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Harman, Gary E., and Ilan Chet. Discovery and Use of Genes and Gene Combinations Coding for Proteins Useful in Biological Control. United States Department of Agriculture, 1994. http://dx.doi.org/10.32747/1994.7568787.bard.

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The objectives of the research in this proposal were to (A) identify synergy among proteins that provide enhanced activity over single proteins for control of plant pathogenic fungi, (B) clone and characterize genetic sequences coding for proteins with ability to control pathogenic fungi, (C) produce transgenic organisms with enhanced biocontrol ability using genes and gene combinations and determine their efficiency in protecting plants against plant pathogenic fungi. A related objective was to produce disease-resistant plants. Fungal cell wall degrading enzymes from any source are strongly s

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Cytryn, Eddie, Mark R. Liles, and Omer Frenkel. Mining multidrug-resistant desert soil bacteria for biocontrol activity and biologically-active compounds. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7598174.bard.

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Control of agro-associated pathogens is becoming increasingly difficult due to increased resistance and mounting restrictions on chemical pesticides and antibiotics. Likewise, in veterinary and human environments, there is increasing resistance of pathogens to currently available antibiotics requiring discovery of novel antibiotic compounds. These drawbacks necessitate discovery and application of microorganisms that can be used as biocontrol agents (BCAs) and the isolation of novel biologically-active compounds. This highly-synergistic one year project implemented an innovative pipeline aimed

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Cheeseman, Kathryn. The Environmental Impacts of Illicit Drug Production. Institute of Development Studies, 2024. http://dx.doi.org/10.19088/k4dd.2024.017.

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This rapid evidence review compiles findings on the environmental impacts of illicit drug production, focusing on water and soil pollution, ecosystem health, land use change, and waste management. It highlights the complexity of the issue, with significant gaps in understanding the long-term effects on ecosystems. The review also examines how prohibitionary drug policies may exacerbate environmental harm. Key findings include distinct regional patterns of drug use, complex relationships between land use change and drug production, and the persistence of biologically active compounds in water s

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Kanner, Joseph, Mark Richards, Ron Kohen, and Reed Jess. Improvement of quality and nutritional value of muscle foods. United States Department of Agriculture, 2008. http://dx.doi.org/10.32747/2008.7591735.bard.

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Food is an essential to our existence but under certain conditions it could become the origin to the accumulative health damages. Technological processes as heating, chopping, mincing, grounding, promote the lipid oxidation process in muscle tissues and meat foodstuffs. Lipid oxidation occurred rapidly in turkey muscle, intermediate in duck, and slowest in chicken during frozen storage. Depletion of tocopherol during frozen storage was more rapid in turkey and duck compared to chicken. These processes developed from lipid peroxides produce many cytotoxic compounds including malondialdehyde (MD

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Jurkevitch, Edouard, Carol Lauzon, Boaz Yuval, and Susan MacCombs. role of nitrogen-fixing bacteria in survival and reproductive success of Ceratitis capitata, the Mediterranean fruit fly. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7695863.bard.

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Objectives: to demonstrate nitrogen fixation in the gut of Ceratitiscapitata, the Mediterranean fruit fly and that fixed nitrogen is important for the fly. Background: Fruit flies (Diptera: Tephritidae) are a highly successful, widespread group of insects causing enormous economic damage in agriculture. They are anautogenous, i.e. the acquisition of nitrogenous compounds by both male and female is essential for the realization of their reproductive potential. Nitrogen, although abundant in the atmosphere, is paradoxically a limiting resource for multicellular organisms. In the Animalia, biolog

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Mevarech, Moshe, Jeremy Bruenn, and Yigal Koltin. Virus Encoded Toxin of the Corn Smut Ustilago Maydis - Isolation of Receptors and Mapping Functional Domains. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7613022.bard.

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Ustilago maydis is a fungal pathogen of maize. Some strains of U. maydis encode secreted polypeptide toxins capable of killing other susceptible strains of U. maydis. Resistance to the toxins is conferred by recessive nuclear genes. The toxins are encoded by genomic segments of resident double-strande RNA viruses. The best characterized toxin, KP6, is composed of two polypeptides, a and b, which are not covalently linked. It is encoded by P6M2 dsRNA, which has been cloned, sequenced and expressed in a variety of systems. In this study we have shown that the toxin acts on the membranes of sensi

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Lichter, Amnon, Joseph L. Smilanick, Dennis A. Margosan, and Susan Lurie. Ethanol for postharvest decay control of table grapes: application and mode of action. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7587217.bard.

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Original objectives: Dipping of table grapes in ethanol was determined to be an effective measure to control postharvest gray mold infection caused by Botrytis cinerea. Our objectives were to study the effects of ethanol on B.cinerea and table grapes and to conduct research that will facilitate the implementation of this treatment. Background: Botrytis cinerea is known as the major pathogen of table grapes in cold storage. To date, the only commercial technology to control it relied on sulfur dioxide (SO₂) implemented by either fumigation of storage facilities or from slow release generator pa

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Kumar, Aishani, Thendral Yalini, and Sunil Kumar C. Unlocking Cellular Control: The Promise of PROTACs in Disease Intervention. Science Reviews - Biology, 2024. http://dx.doi.org/10.57098/scirevs.biology.3.2.1.

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The discovery of proteolysis-targeting chimeras (PROTACs) is among the most exciting and promising avenues in cancer therapy. These fascinating compounds signify a paradigm shift from traditional approaches to medication development, offering a new idea that leverages the complexities of biological mechanisms to accomplish highly focused degradation of particular proteins implicated in pathological processes. This novel strategy has the potential to address a number of drawbacks with conventional therapy techniques, such as the development of drug resistance and unexpected adverse effects resu

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Kanner, Joseph, Dennis Miller, Ido Bartov, John Kinsella, and Stella Harel. The Effect of Dietary Iron Level on Lipid Peroxidation of Muscle Food. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7604282.bard.

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Biological oxidations are almost exclusively metal ion-promoted reactions and in ths respect iron, being the most abundant, is the commonly involved. The effect of dietary iron levels on pork, turkey and chick muscle lipid peroxidation and various other related compounds were evaluated. Crossbred feeder pigs were fed to market weight on corn-soy rations containing either 62, 131 or 209 ppm iron. After slaughter, the muscles were dissected, cooked and stored at 4°C. Heavily fortifying swine rations with iron (>200 ppm) increase nn-heme iron (NHI), thiobarbituric acid reactive substances (TBA

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