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Journal articles on the topic 'Biological active compound'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Ježek, Jan, Milan Zaoral, Miloš Buděšínský, Jiří Günther, and Jiří Rotta. "Muramyl-dipeptide analogues: Synthesis and biological activities." Collection of Czechoslovak Chemical Communications 53, no. 11 (1988): 2897–906. http://dx.doi.org/10.1135/cccc19882897.

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In the search for immunoadjuvant active compounds without pyrogenic activity we prepared N-Ac-norMur-L-Abu-D-Gln-O-Bu (V), N-Ac-Mur-L-Abu-D-Gln-O-Bu (VII) and their respective α-benzylglycosides VI and VIII. All the prepared compounds are nonpyrogenic. In the delayed hypersensitivity test, compound V is inactive, VI is comparable to MDP, VII is more and VIII is less active than MDP.

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2

Kumar, Navneet, Anjali Chauhan, Anuj, and Prachi. "Green and Benign Strategies for Synthesis of Biologically Active Compounds using Lipase as Biocatalyst." Bulletin of Pure and Applied Sciences-Chemistry 42, no. 1 (2023): 33–40. http://dx.doi.org/10.48165/bpas.2023.42c.1.6.

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An efficient, feasible, mild, affordable, and environmentally friendly method has been developed for the synthesis of biologically active compound 3-methylene-indoline-2-one from Isatin and active methylene compounds using Lipase as a Green and Biocatalyst. Biological Processes are very important to optimization to increase and improve the efficiency of cost. In this project, Malononitrile, or Dimedone reacts with Isatin in presence of lipase. The essential features of this approach are metal-free reaction, high yield, nontoxic, and less hazardous. These reactions surpass metal-catalyzed proce

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3

Appell, Kenneth C., Thomas D. Y. Chung, Michael J. H. Ohlmeyer, Nolan H. Sigal, John J. Baldwin, and Daniel Chelsky. "Biological Screening of a Large Combinatorial Library." Journal of Biomolecular Screening 1, no. 1 (1996): 27–31. http://dx.doi.org/10.1177/108705719600100111.

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Encoding technology has allowed for the creation of libraries of 50,000 or more low-molecular-weight compounds for biological testing. The current challenge is to properly and efficiently screen among these compounds for useful biological activities. In this example, actives against two related G-protein coupled receptors were sought from a combinatorial library of 56,000 members. The library was synthesized on solid phase using the split synthesis method and photochemically released for testing. At a screening concentration of 0.5-1 /LM, 86 unique structures were identified as active against

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4

Simonetti, Giorgia, Carla Boga, Joseph Durante, et al. "Synthesis of Novel Tryptamine Derivatives and Their Biological Activity as Antitumor Agents." Molecules 26, no. 3 (2021): 683. http://dx.doi.org/10.3390/molecules26030683.

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We synthesized five novel tryptamine derivatives characterized by the presence of an azelayl chain or of a 1,1,1-trichloroethyl group, in turn connected to another heterocyclic scaffold. The combination of tryptamin-, 1,1,1-trichloroethyl- and 2-aminopyrimidinyl- moieties produced compound 9 identified as the most active compound in hematological cancer cell lines (IC50 = 0.57–65.32 μM). Moreover, keeping constant the presence of the tryptaminic scaffold and binding it to the azelayl moiety, the compounds maintain biological activity. Compound 13 is still active against hematological cancer ce

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5

Cowley, Phillip M., and David C. Rees. "Applications of Solid-Phase Synthesis to Drug Discovery." Current Medicinal Chemistry 4, no. 3 (1997): 211–27. http://dx.doi.org/10.2174/0929867304999220313112224.

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This review aims to highlight the opportunities for the utilisation of solid-phase synthesis in the process of drug discovery. The two main sections discuss the preparation and biological testing of compound libraries and the preparation of compound arrays based around approved drugs. Biologically active compounds in assays for enzyme inhibition, membrane bound protein ligands and intracellular hormone receptors are discussed, illustrating the power of this relatively new tool in the arena of medicinal chemistry.

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6

Patel, Rajat, Puja Sharma, Rohit R. Koshti, Akshay Vyas, and Chetan B. Sangani. "Synthesis, Biological Evaluation, DFT Studies and Molecular Docking of Novel 4-(5-(1H-Imidazol-1-yl)-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-amino-3-methyl- 1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile and its Derivatives." Asian Journal of Chemistry 35, no. 7 (2023): 1616–24. http://dx.doi.org/10.14233/ajchem.2023.27921.

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A novel series consisting of eight imidazol-pyrazole hybrids ( 9a-h) are synthesized using a base catalyzed one pot multi-component reaction (MCR) and screened for in vitro biological activities. All compounds were found to display high biological activities but compound 9g was found to be the most active against EGFR (IC50 of 0.11 ± 0.02 μm), A549 and HepG2, while compound 9h was found to be most active against FabH (IC50 of 2.6 μm) E. coli. The DFT studies and molecular docking was done for compounds 9a-h to calculate the distance and angle between the active parts of the molecules and charg

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7

Khan, Khalid M., Zafar S. Saifyb, Abdullah Khan, et al. "Syntheses of Selected Quaternary Phenacylbromopyridinium Compounds and their Biological Evaluation." Zeitschrift für Naturforschung B 54, no. 9 (1999): 1210–18. http://dx.doi.org/10.1515/znb-1999-0920.

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The studies, presented here, deal with the synthetic modification of 5-bromonicotinic acid on its nitrogen nucleus. The synthetic transformations were carried out by reacting equimolar amounts of 5-bromonicotinic acid and phenacyl halides in acetone. A range of phenacyl halides were used with the objective of getting a variety of quaternary ammonium salts of 5- bromonicotinic acid derivatives as multipurpose biologically active compounds. Twelve quaternary ammonium salts of 5-bromonicotinic acid have been synthesized and tested for cytotoxicity, antibacterial and antifungal activities. These c

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8

Kadomtseva, Alena V., Georgy M. Mochalov, Maria A. Zasovskaya, and Anatoly M. Ob’edkov. "Synthesis, Structure, and Biological Activity of the Germanium Dioxide Complex Compound with 2-Amino-3-Hydroxybutanoic Acid." Inorganics 12, no. 3 (2024): 83. http://dx.doi.org/10.3390/inorganics12030083.

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Currently, a promising direction of study is the use of biologically active coordination compounds in the pharmacopoeia and the creation of effective bactericidal drugs, biomaterials, and enzyme modulators on that basis. The paper considers a coordination germanium compound with 2-amino-3-hydroxybutanoic acid. The prospects for the use of the compound in medicine are outlined. This work is aimed at solving the problems regarding the synthesis of biologically active compounds with a wide spectrum of actions. The structure and composition of the coordination compound have been established throug

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Albien, Anna-Lena, and Timo D. Stark. "(Bio)active Compounds in Daisy Flower (Bellis perennis)." Molecules 28, no. 23 (2023): 7716. http://dx.doi.org/10.3390/molecules28237716.

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The common daisy (Bellis perennis) belongs to the family Asteraceae and, in recent years, some new research has been published on the bioactive compounds and biological activities of its extracts. In 2014, the knowledge was partially summarized, but several new studies have been published in the last nine years. In addition, the substances were tabularly consolidated to give a comprehensive overview of over 310 individual components, compound classes, and bioactivities, as well as their accurate plant organ origin. The latest results have shown that the plant has antioxidative, antimicrobial,

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10

Ruwizhi, Ngonidzashe, and Blessing Atim Aderibigbe. "Cinnamic Acid Derivatives and Their Biological Efficacy." International Journal of Molecular Sciences 21, no. 16 (2020): 5712. http://dx.doi.org/10.3390/ijms21165712.

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The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes and neurological disorders, among many, has been reported. Cinnamic acid is obtained from cinnamon bark. Its structure is composed of a benzene ring, an alkene double bond and an acrylic acid functional group making it possible to modify the aforementioned functionalities with a variety of compounds resulting in bioactive agents with enhanced efficacy. The nature of the substituents incorporated into cinnamic acid has been found to play a huge role in either enhancing or decreasing the biological ef

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11

Manjula, J., and R. Maheswari. "BIOLOGICAL AND DOCKING STUDIES OF NOVEL AROYLHYDRAZONES." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 5 (2017): 81. http://dx.doi.org/10.22159/ijpps.2017v9i5.10862.

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Objective: Novel aroylhydrazone schiff bases were synthesized and were screened for their biological activities.Methods: Using HCl as a catalyst, all the compounds were synthesized at room temperature and were characterized by IR and NMR techniques. The synthesized Schiff bases were screened for antibacterial, antifungal activities. In silico molecular docking, method was performed to study their anti-tuberculosis activity against enoyl acyl carrier protein reductase (InhA) from Mycobacterium tuberculosis (PDB id: 2NSD). Results: Compound P1 showed good antibacterial activity against gram posi

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12

Kumar Baba, N. H., D. Ashok, Boddu Ananda Rao, Sarasija Madderla, and N. Y. S. Murthy. "Microwave-assisted synthesis and biological evaluation of thiazole-substituted dibenzofurans." Heterocyclic Communications 24, no. 3 (2018): 171–76. http://dx.doi.org/10.1515/hc-2017-0247.

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AbstractNew thiazole-substituted dibenzofurans 7a–j were synthesized from dibenzofuran derivatives 5a–b and substituted thiosemicarbazones 6a–h under conventional and microwave irradiation conditions. The structures of all products were established on the basis of analytical and spectral data. The synthesized compounds were evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative strains. Compounds 7b, 7d and 7h are active against Bacillus subtilis (+ve), and compound 7i displays good activity against Pseudomonas aeruginosa (-ve) strain. Compounds 7a–j were a

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13

Norin, Torbjörn. "Pheromones and kairomones for control of pest insects. Some current results from a Swedish research program." Pure and Applied Chemistry 73, no. 3 (2001): 607–12. http://dx.doi.org/10.1351/pac200173030607.

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Some recent results from a research program dealing with the isolation, identification, and synthesis of biologically active compounds for applications in agriculture and forestry will be reported. The solid-phase micro extraction (SPME) technique has been successfully used for identification of the main sex pheromone components of Cydia and Bonagota species (Lepidoptera, Tortricidae). Synthesis of a series of dodecadienols, tetradecadienols, and their corresponding aldehydes and acetates have been performed to be used for testing inhibitory and synergistic effects on pest insects of these spe

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14

Somani, Rakesh R., Anuj G. Agrawal, Pushkar P. Kalantri, Pratibha S. Gavarkar, and Erik De Clercq. "Investigation of 1, 3, 4-Oxadiazole Scaffold as Potentially Active Compounds." International Journal of Drug Design and Discovery 2, no. 1 (2011): 353–60. https://doi.org/10.37285/ijddd.2.1.1.

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In the present work, various Schiff’s bases of isoniazid bearing 1, 3, 4-oxadiazole nucleus were synthesized. These compounds were purified, characterized and evaluated in vitro for antibacterial, antifungal and antiviral activities. Compound 5 showed better biological profile.

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15

Nakagawa, Toshinori, Ahmed E. Allam, Koichiro Ohnuki, and Kuniyoshi Shimizu. "Biological Activities of Extracts from Different Parts of two Cultivars of Prunus persica ‘Akatsuki’ and ‘Fastigiata’." Natural Product Communications 13, no. 10 (2018): 1934578X1801301. http://dx.doi.org/10.1177/1934578x1801301015.

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We investigated the antioxidant, anti-lipase and anti-dementia activities of peach ( Prunus persica (L.) Batsch) fruit and its by-products. The ethanol extracts of branch showed relatively high activity in all biological activities. Then, the extract was fractionated, and eight compounds were isolated from the ethyl acetate fraction. Results showed 4,2’,4'-trihydroxy-6'-methoxychalcone 4'- O-β-D-glucopyranoside (5) and quercetin 3- O-β-D-glucopyranoside (7) as newly identified compounds in P. persica. From the biological investigation, it was considered that quercetin 3- O-β-D-glucopyranoside

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16

Rostas, Arpad Mihai, Mihaela Badea, Lavinia L. Ruta, et al. "Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species." Molecules 25, no. 17 (2020): 3777. http://dx.doi.org/10.3390/molecules25173777.

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Complexes with mixed ligands [Cu(N-N)2(pmtp)](ClO4)2 ((1) N-N: 2,2′-bipyridine; (2) L: 1,10-phenanthroline and pmpt: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesized and structurally and biologically characterized. Compound (1) crystallizes into space group Pa and (2) in P-1. Both complexes display an intermediate stereochemistry between the two five-coordinated ones. The biological tests indicated that the two compounds exhibited superoxide scavenging capacity, intercalative DNA properties, and metallonuclease activity. Tests on various cell systems indicated that the two c

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17

B. Bakare, S. "Synthesis of novel nitrogen heterocycles bearing biological active carboxamide moiety as potential antitumor agents." Bulletin of the Chemical Society of Ethiopia 35, no. 2 (2021): 449–59. http://dx.doi.org/10.4314/bcse.v35i2.17.

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ABSTRACT. In the present study, synthesis of a simple series of nitrogen heterocycles containing N-(p-bromophenyl) carboxamide moiety, such as benzimidazole, benzoxazine, oxadiazole and triazole compounds, by using 4-bromo aniline and diethyl oxalate as a key starting material has been described. Five nitrogen heterocycles compounds moiety were evaluated for their anticancer activity against MCF-7 cell line. The results revealed that compound 8 (N-(4-bromophenyl)-5-thioxo-1,3,4-oxadiazole-2-carboxamide) was the most potent cytotoxic activity. Cell cycle analysis demonstrated that compound 8 in

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18

Gür, Zehra Tuğçe, Fatma Sezer Şenol, Suhaib Shekfeh, İlkay Erdoğan Orhan, Erden Banoğlu, and Burcu Çalişkan. "Novel Piperazine Amides of Cinnamic Acid Derivatives as Tyrosinase Inhibitors." Letters in Drug Design & Discovery 16, no. 1 (2018): 36–44. http://dx.doi.org/10.2174/1570180815666180420105652.

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Background: A series of novel cinnamic acid piperazine amide derivatives has been designed and synthesized, and their biological activities were also evaluated as potential tyrosinase inhibitors. Methods: Compounds 9, 11 and 17 showed the most potent biological activity (IC50 = 66.5, 61.1 and 66 &#181;M, respectively). In silico docking simulation was performed to position compound 11 into the Agaricus bisporus mushroom tyrosinase’s active site to determine the putative binding interactions. Results and Conclusion: The results indicated that compound 11 could serve as a promising lead comp

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19

Culletta, Giulia, Mario Allegra, Anna Maria Almerico, Ignazio Restivo, and Marco Tutone. "In Silico Design, Synthesis, and Biological Evaluation of Anticancer Arylsulfonamide Endowed with Anti-Telomerase Activity." Pharmaceuticals 15, no. 1 (2022): 82. http://dx.doi.org/10.3390/ph15010082.

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Telomerase, a reverse transcriptase enzyme involved in DNA synthesis, has a tangible role in tumor progression. Several studies have evidenced telomerase as a promising target for developing cancer therapeutics. The main reason is due to the overexpression of telomerase in cancer cells (85–90%) compared with normal cells where it is almost unexpressed. In this paper, we used a structure-based approach to design potential inhibitors of the telomerase active site. The MYSHAPE (Molecular dYnamics SHared PharmacophorE) approach and docking were used to screen an in-house library of 126 arylsulfona

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20

Sambrajyam, J., M. Vidya Rani, and G. Rajitha. "Synthesis, Molecular Docking and Biological Evaluation of Napthyl N-Acyl Hydrazone Derivatives." Asian Journal of Chemistry 34, no. 7 (2022): 1675–82. http://dx.doi.org/10.14233/ajchem.2022.23632.

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A series of 2-(benzamido)-N′-((naphthalen-1-yl)methylene)-3-(substituted phenyl)acrylo hydrazides (4a-m, 5a-b) were synthesized by condensation of 2-(benzamido)-3-(substituted phenyl)acrylohydrazides with 1-naphthaldehyde in presence of few drops of acetic acid in ethanol. Structural elucidation of final compounds was confirmed by spectral data. Title compounds were evaluated for antioxidant and antibacterial activities and subjected to in silico studies and molecular docking studies with cyclooxygenase-II (COX-II, PDB I’d: 3LN1) and active compounds from docking studies were selected for in v

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21

Kim, Jisu, Kang Pa Lee, Myoung-Ryu Kim, et al. "A network pharmacology approach to explore the potential role of Panax ginseng on exercise performance." Physical Activity and Nutrition 25, no. 3 (2021): 28–35. http://dx.doi.org/10.20463/pan.2021.0018.

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[Purpose] As Panax ginseng C. A. Meyer (ginseng) exhibits various physiological activities and is associated with exercise, we investigated the potential active components of ginseng and related target genes through network pharmacological analysis. Additionally, we analyzed the association between ginseng-related genes, such as the G-protein-coupled receptors (GPCRs), and improved exercise capacity.[Methods] Active compounds in ginseng and the related target genes were searched in the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). Gene ontology functional analysis was pe

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22

Ibrahim, Marwa A., Riham F. George, Sahar M. Abou-Seri, and Samir M. El-Moghazy. "Synthesis of new phenolic compounds and biological evaluation as antiproliferative agents." Journal of Chemical Research 44, no. 3-4 (2019): 181–92. http://dx.doi.org/10.1177/1747519819895238.

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New series of phenolic azomethine compounds in addition to 5-arylidene thiazolidinones are synthesized and screened for their anticancer activity against the brain cancer cell line SNB-75 and non-small lung cancer cells HOP-92. The azomethine derivative 12b is the most active compound against SNB-75 displaying an IC50 value of 0.14 μM. Compounds 7b, 16a and 27d display submicromolar activity against the HOP-92 cell line with IC50 values of 0.73, 0.74 and 0.81 μM, respectively. Moreover, studying the cytotoxic effects of the most active compounds against normal lung cells WI-38 revealed that co

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23

Anupam, Anupam, Mohammed Al-Bratty, Hassan Ahmad Alhazmi, et al. "Synthesis and biological evaluation of triphenyl-imidazoles as a new class of antimicrobial agents." European Journal of Chemistry 9, no. 4 (2018): 369–74. http://dx.doi.org/10.5155/eurjchem.9.4.369-374.1785.

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Newer triphenyl-imidazole derivatives (4a-h) were synthesized in good yields by the reaction of benzil and substituted benzaldehydes in equimolar quantities and refluxing the product with acetyl chloride thereafter. Structures were confirmed by using FT-IR, 1H NMR and 13C NMR spectroscopic methods. All the synthesized compounds were tested for their antimicrobial activity using agar diffusion technique against Gram positive (Staphhylococcus aureus and Bacillus subtilis), Gram negative (Escherichia coli and Pseudomonas aureginosa) as well as Fungal strain (Candida albicans). Interestingly compo

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LAMPIS, GIORGIO, DELIA DEIDDA, CARLO MAULLU, et al. "Karalicin, a New Biologically Active Compound from Pseudomonas fluorescens/putida. II. Biological Properties." Journal of Antibiotics 49, no. 3 (1996): 263–66. http://dx.doi.org/10.7164/antibiotics.49.263.

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25

Rajesh, Kumar, and C. Joshi Y. "Synthesis and biological activity of 3H-1,5-benzodiazepine derivatives." Journal of Indian Chemical Society Vol. 84, Dec 2007 (2007): 1261–65. https://doi.org/10.5281/zenodo.5826732.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India <em>E-mail</em> : rnunia@yahoo.com <em>Manuscript received 11 January 2007, revised 30 August 2007, accepted 18 September 200</em>7 Acylation of 5-(2-cthoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7<em>H</em>-pyrazolo[4,3-dipyrirnidin-7-one (1) with chloroacctyl chloride in the presence of anyhydrous aluminium chloride affords 5-[(5-chloroacctyl-2-ethoxy)pyrimidin]-1-methyl-3-propyl-1,6-dihydro-71<em>H</em>- pyrazolo[4,3-djpyrimidin-7-one (2). Compound 2 condensed with dillerent dicarbonyl compound (3a-e) to o

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26

Yusupova, Ugiloy Yusufovna, Nurmurod Sheralievich Ramazonov, Khairulla Mamadievich Bobakulov, Feruza Rustamovna Egamova, Vladimir Nikolaevich Syrov, and Durbek Abdikhoshimovich Usmanov. "BIOLOGICAL ACTIVE COMPONENTS OF SILENE TOMENTELLA AND THEIR PHARMACOLOGICAL PROPERTIES." chemistry of plant raw material, no. 1 (March 16, 2021): 197–202. http://dx.doi.org/10.14258/jcprm.2021018323.

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In thepresent investigation isolation of chemical compounds was carried out from the aerial part of Silene tomentella, an evergreen member of the family Caryophyllaceae, using column chromatography. Identification of chemical compounds was done by various MP, TLC, IR, NMR techniques. The presence of the bioactive compound D-pinitol in this plant is being reported for the first time. Under the influence of D-pinitol, a clear tendency towards normalization of the glycogen content in the liver was also noted (it was only 10.4% lower than in intact animals). In the liver of animals, a rather sharp

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27

Arciniegas, Amira, Luis Angel Polindara, Ana L. Pérez-Castorena, et al. "Chemical Composition and Biological Activity of Laennecia schiedeana." Zeitschrift für Naturforschung C 66, no. 3-4 (2011): 115–22. http://dx.doi.org/10.1515/znc-2011-3-404.

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The chemical study of Laennecia schiedeana afforded three sterols, five diterpenes, five flavonoids, three caffeoyl derivatives of quinic acid, and two triterpenes. Evaluation of the cytotoxic activity of the extracts and isolated metabolites showed that 15-methoxy-16-oxo- 15,16H-strictic acid was the most active compound [(15.05 ± 2.2) μg/mL against U-251 cells]. In antibacterial assays the acetonic extract of leaves was the only active extract exhibiting its highest effect against the multiresistant Staphylococcus epidermidis (MIC 0.25 mg/mL). The anti-inflammatory activity observed was mild

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Kumar, N., and D. Pathak. "SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NEWER BENZIMIDAZOLE DERIVATIVES BY MANNICH REACTION." INDIAN DRUGS 56, no. 07 (2019): 16–22. http://dx.doi.org/10.53879/id.56.07.11797.

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O-phenylenediamine and salicylic acid were used for the synthesis of 2-(1-(substituted phenylamino) methyl-1H benzo[d] imidazol-2-yl) phenol (2a-2h) derivatives by using various substituted aniline. In the first step, reaction of o-phenylenediamine and salicylic acid yielded 2-(1H-benzo[d]imidazol-2-yl) phenol (1), which on Mannich reaction with substituted aniline gave compounds (2a-2h). The structures of these compounds were characterized by IR, 1H NMR, mass spectral data and elemental analysis. Each analogue was tested in vitro for various types of pharmacological activity of this class of

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Hu, Wei, Wanjin Fu, Xin Wei, Yang Yang, Chao Lu, and Zeyuan Liu. "A Network Pharmacology Study on the Active Ingredients and Potential Targets ofTripterygium wilfordiiHook for Treatment of Rheumatoid Arthritis." Evidence-Based Complementary and Alternative Medicine 2019 (April 15, 2019): 1–15. http://dx.doi.org/10.1155/2019/5276865.

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Traditional Chinese medicine has specific effect on some chronic diseases in clinic, especially in rheumatic diseases.Tripterygium wilfordiiHook (TWH) is a traditional Chinese medicine commonly used in the treatment of rheumatoid arthritis (RA); the unique therapeutic effect has been confirmed by a large number of research papers. TWH has many compounds that lead to its active compounds. However, the potential targets and pharmacological and molecular mechanism of its action treatment of rheumatic diseases are not entirely clear. Therefore, the network pharmacology approach is needed to furthe

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Skrzypek, Alicja, Monika Karpińska, Małgorzata Juszczak, et al. "Cholinesterases Inhibition, Anticancer and Antioxidant Activity of Novel Benzoxazole and Naphthoxazole Analogs." Molecules 27, no. 23 (2022): 8511. http://dx.doi.org/10.3390/molecules27238511.

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Benzoxazole and naphthoxazole fused systems are found in many biologically active molecules. Novel benzoxazole and naphthoxazole analogs functionalized by the 2,4-dihydroxyphenyl moiety were designed, obtained and evaluated as a broad spectrum of biological potency compounds. Sulfinylbis[(2,4-dihydroxyphenyl)methanethione] or its analogs and 2-aminophenols or 1-amino-2-naphthol were used as starting reagents. 4-(Naphtho[1,2-d][1,3]oxazol-2-yl)benzene-1,3-diol was identified as the most promising compound of the nanomolar activity against AChE (IC50 = 58 nM) of the mixed-type inhibition and of

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Safriansyah, Wahyu, Siska Elisahbet Sinaga, Unang Supratman, and Desi Harneti. "Phytochemistry and Biological Activities of Guarea Genus (Meliaceae)." Molecules 27, no. 24 (2022): 8758. http://dx.doi.org/10.3390/molecules27248758.

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Guarea is one of the largest genera of the American Meliaceae family, consisting of over 69 species which are widely distributed in Mexico, Argentina, and Africa and are used in traditional medicine for several diseases. Previous studies reported that the Guarea species produce secondary metabolites such as sesquiterpenoid, diterpenoid, triterpenoid, limonoid, steroid, and aromatic compounds. The preliminary chemical investigation commenced by isolating the limonoid compound, dihydrogedunin, in 1962; then, 240 compounds were obtained from the isolation and hydrodistillation process. Meanwhile,

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Adamovich, Sergey N., Igor A. Ushakov, Elizaveta N. Oborina, Svetlana V. Lukyanova, and Vladislav Y. Komarov. "New 3-Aminopropylsilatrane Derivatives: Synthesis, Structure, Properties, and Biological Activity." International Journal of Molecular Sciences 24, no. 12 (2023): 9965. http://dx.doi.org/10.3390/ijms24129965.

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The biologically active compound 3-aminopropylsilatrane (a compound with a pentacoordinated silicon atom) underwent an aza-Michael reaction with various acrylates and other Michael acceptors. Depending on the molar ratio, the reaction yielded Michael mono- or diadducts (11 examples) containing functional groups (silatranyl, carbonyl, nitrile, amino, etc.). These compounds were characterized via IR and NMR spectroscopy, mass spectrometry, X-ray diffraction, and elemental analysis. Calculations (using in silico, PASS, and SwissADMET online software) revealed that the functionalized (hybrid) sila

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Sharma, Piush, and Charanjeet Singh. "Synthesis, characterization and biological evaluation of some novel N-Mannich bases of heterocyclic 1,3,4-thiadiazole." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 220–28. http://dx.doi.org/10.22270/jddt.v9i4-a.3332.

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A series of some novel N-Mannich bases of heterocyclic 1,3,4-thiadiazole were synthesized through the condensation reaction of 1,3,4-thiadiazole containing a aromatic secondary amine, aromatic aldehydes and cyclic compounds employing Mannich reaction and using conventional synthesis. All the synthesized compounds were obtained in the range of 57.41-83.3 % yield. The structures of synthesized compounds were confirmed by UV, IR, 1H NMR spectroscopy. the essential structural features responsible for interaction with receptor site are established within a suggested pharmacophore. The in vitro anti

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Journal, Baghdad Science. "Synthesis, Characterization and Biological Activates Studies of some New Derivatives From 2-aminoo-5-mercapto-1, 3, 4-thiadiazole." Baghdad Science Journal 15, no. 1 (2018): 48–56. http://dx.doi.org/10.21123/bsj.15.1.48-56.

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In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5-mercapto-1, 3, 4-thiadiazole) as a starting material base. The main heterocyclic compounds (1, 3, 4-thiadiazole, oxazole) etc, 2-amino-5-mercapto-1,3,4-thiadiazole compound (1) was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and carbon disulfide. Oxidation of (1) via hydrogen peroxide, to have (2) which was treated with chloro acetyl chloride to get (3). Preparation of thiazole ring (4) was from reacting of (3) with thiourea. Synthesis of diazonium

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Jalmakhanbetova, Roza I., Gulim K. Mukusheva, Alisher Sh Abdugalimov, et al. "Synthesis and Investigation of Biological Activity of New Betulonic Acid Derivatives Containing 1,2,3-Triazole Fragments." Molecules 29, no. 13 (2024): 3149. http://dx.doi.org/10.3390/molecules29133149.

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The results of this study showed that the compounds synthesized by the authors have significant potential due to their antibacterial and cytotoxic properties. The apparent antibacterial activity demonstrated by the compounds suggests that they are active antimicrobial agents against common microbial pathogens that cause various socially significant infectious diseases. Compound 6 showed pronounced antimicrobial activity against the Gram-positive test strain Staphylococcus aureus ATCC 6538, and compound 7 demonstrated pronounced antimicrobial activity against the Gram-negative test strain Esche

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Ziarani, Ghodsi M., Fatemeh Mohajer, Razieh Moradi, and Parisa Mofatehnia. "The Molecular Diversity Scope of Urazole in the Synthesis of Organic Compounds." Current Organic Synthesis 16, no. 7 (2019): 953–67. http://dx.doi.org/10.2174/1570179416666190925162215.

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Background: As a matter of fact, nitrogen as a hetero atom among other atoms has had an important role in active biological compounds. Since heterocyclic molecules with nitrogen are highly demanded due to biological properties, 4-phenylurazole as a compound containing nitrogen might be important in the multicomponent reaction used in agrochemicals, and pharmaceuticals. Considering the case of fused derivatives “pyrazolourazoles” which are highly applicable because of their application for analgesic, antibacterial, anti-inflammatory and antidiabetic activities as HSP-72 induction inhibitors (I

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Yang, Kailin, Liuting Zeng, and Jinwen Ge. "Exploring the Pharmacological Mechanism of Danzhi Xiaoyao Powder on ER-Positive Breast Cancer by a Network Pharmacology Approach." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–20. http://dx.doi.org/10.1155/2018/5059743.

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Background. Breast cancer is the most common malignancy among women worldwide, but the long-term endocrine therapy is frequently associated with adverse side effects. Danzhi Xiaoyao powder (DXP) is a herbal formula that has an effect on breast cancer, especially ER-positive breast cancer. However, the active compounds, potential targets, and pharmacological and molecular mechanism of its action against cancer remain unclear.Methods. A network pharmacology approach comprising drug-likeness evaluation, oral bioavailability prediction, Caco-2 permeability prediction, multiple compound target pred

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Lu, Chao-Fan, Sheng-Hui Wang, Xiao-Jing Pang, et al. "Synthesis and Biological Evaluation of Amino Chalcone Derivatives as Antiproliferative Agents." Molecules 25, no. 23 (2020): 5530. http://dx.doi.org/10.3390/molecules25235530.

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Chalcone is a common scaffold found in many biologically active compounds. The chalcone scaffold was also frequently utilized to design novel anticancer agents with potent biological efficacy. Aiming to continue the research of effective chalcone derivatives to treat cancers with potent anticancer activity, fourteen amino chalcone derivatives were designed and synthesized. The antiproliferative activity of amino chalcone derivatives was studied in vitro and 5-Fu as a control group. Some of the compounds showed moderate to good activity against three human cancer cells (MGC-803, HCT-116 and MCF

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Kim, En Hyung, and Wonnam Kim. "An Insight into Ginsenoside Metabolite Compound K as a Potential Tool for Skin Disorder." Evidence-Based Complementary and Alternative Medicine 2018 (June 25, 2018): 1–8. http://dx.doi.org/10.1155/2018/8075870.

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Ginsenosides are the major bioactive natural compounds derived from Panax ginseng. Several studies report the pharmaceutical benefits of several ginsenosides, including antidementia, antitumor, and anti-inflammatory activity. Biotransformations by gut microbiome contribute to the biological function of these ginsenosides. After ingestion ginsenosides are hydrolyzed to Rg2, Rg3, compound K, and others by human gut flora. Compound K is considered the representative active metabolite after oral administration of ginseng or ginsenosides. Various studies report the diverse biological functions of c

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Jastrząb, Anna, Iwona Jarocka-Karpowicz, and Elżbieta Skrzydlewska. "The Origin and Biomedical Relevance of Cannabigerol." International Journal of Molecular Sciences 23, no. 14 (2022): 7929. http://dx.doi.org/10.3390/ijms23147929.

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The constant search for new pharmacologically active compounds, especially those that do not exhibit toxic effects, intensifies the interest in plant-based ingredients and their potential use in pharmacotherapy. One of the plants that has great therapeutic potential is Cannabis sativa L., a source of the psychoactive Δ9-tetrahydrocannabinol (Δ9-THC), namely cannabidiol (CBD), which exhibits antioxidant and anti-inflammatory properties, and cannabigerol (CBG)—a biologically active compound that is present in much smaller quantities. CBG is generated during the non-enzymatic decarboxylation of c

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Kondratenko, Yu A., D. V. Lezov, A. A. Stro, V. L. Ugolkov, and T. A. Kochina. "Hypercoordinated germanium complexes with ligands containing hydroxyalkyl groups." Журнал неорганической химии 69, no. 1 (2024): 14–24. http://dx.doi.org/10.31857/s0044457x24010021.

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Among germatranes, 1-germatranol hydrate is the most well-studied compound with a diverse spectrum of biological activity. Its synthesis is based on a one-stage reaction of tris(2-hydroxyethyl)amine with germanium dioxide in an aqueous medium without the use of organic solvents. In this work, taking into account this approach, new potentially biologically active compounds of germanium with hydroxyalkylamines, sulfo- and amino acids containing hydroxyalkyl groups were synthesized, which we considered as new analogues of biologically active 1-germatranol hydrate. Their formation is confirmed by

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ACAR ÇEVİK, Ulviye, and Tugba ERCETİN. "Design, Synthesis and Evaluation of Pyrrol-thiazole Derivatives as AChE and BuChE Inhibitory and Antioxidant Activities." Cumhuriyet Science Journal 44, no. 4 (2023): 625–28. http://dx.doi.org/10.17776/csj.1255826.

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Thiazole rings are one of the most frequently used heterocyclic moieties and are found in a wide variety of biologically active chemicals. In this research project, we report the synthesis and biological activities of some new thiazole derivatives (2a-2c) as potent anti-Alzheimer’s agents. These final compounds’ structures were characterized by spectral (1H NMR, 13C NMR, and MS spectra) analyses. The highest inhibitory activity against AChE was demonstrated by compound 2c (23.73 ± 0.018 %) with chloro substitution at the meta and para positions of the phenyl ring, while the highest inhibitory

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Yergaliyeva, Elmira, Kulzada Bazhykova, Santanat Abeuova, Vladimir Vazhev, and Peter Langer. "In silico drug-likeness, biological activity and toxicity prediction of new 3,5-bis(hydroxymethyl)tetrahydro-4H-pyran-4-one derivatives." Chemical Bulletin of Kazakh National University, no. 4 (December 3, 2022): 14–20. http://dx.doi.org/10.15328/cb1272.

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This paper presents the results of predicting drug-likeness, biological activity, and toxicity for 8 new derivatives of 3,5-bis(hydroxymethyl)tetrahydro-4H-pyran-4-one using bioinformatic methods. The physicochemical and pharmacokinetic parameters of the studied compounds were determined, in silico screening for biological activity and prediction of their toxicity were carried out. Physicochemical and pharmacokinetic parameters were evaluated using the Molinspiration Cheminformatics service. It was found that compounds 1–11 corresponded to Lipinski’s rule for drug-like compounds. As predicted

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Hosseini Nasab, Narges, Hussain Raza, Rok Su Shim, Mubashir Hassan, Andrzej Kloczkowski, and Song Ja Kim. "Potent Alkaline Phosphatase Inhibitors, Pyrazolo-Oxothiazolidines: Synthesis, Biological Evaluation, Molecular Docking, and Kinetic Studies." International Journal of Molecular Sciences 23, no. 21 (2022): 13262. http://dx.doi.org/10.3390/ijms232113262.

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To develop new alkaline phosphatase inhibitors (ALP), a series of pyrazolo-oxothiazolidine derivatives were synthesized and biologically assessed, and the results showed that all of the synthesized compounds significantly inhibited ALP. Specifically, compound 7g displayed the strongest inhibitory activity (IC50 = 0.045 ± 0.004 μM), which is 116-fold more active than monopotassium phosphate (IC50 = 5.242 ± 0.472 μM) as a standard reference. The most potent compound among the series (7g) was checked for its mode of binding with the enzyme and shown as non-competitively binding with the target en

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Fan, Wang Xi, Ze Fang Li, and Zhou Zhang. "Synthesis and Characterization of Novel Biological Active Material with Aroyl Urea." Advanced Materials Research 507 (April 2012): 56–60. http://dx.doi.org/10.4028/www.scientific.net/amr.507.56.

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This article used thiosemicarbazide and para-pyridinecarboxylic acid to carry out reaction and synthesized 5-(4-pyridyl)-2-amino-1,3,4-thiadiazole, and then reacted with benzoyl isocyanate to synthesize a new type of urea biological active meterial. The structure of the target compound was confirmed by IR, 1H NMR and elemental analysis. The preliminarily biological activity tests show that the target compound has an activity as plant growth regulator, it’s activity as auxin is 19.3% and it’s activity as cytokinin is 27.4%.

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Ritmaleni and Dong-Hwi Kim. "SYNTHETIC STUDY OF Pc-2, AN ACTIVE COMPOUND FROM INDONESIAN RED BETEL LEAF." RASAYAN Journal of Chemistry 16, no. 01 (2023): 122–28. http://dx.doi.org/10.31788/rjc.2023.1617052.

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PC-2 is one of the active compounds isolated from Indonesian red betel leaf. The structure of the compound is named 2-allyl-4-(1'-hydroxy-1'-(3",4",5"-trimethoxyphenyl)propan-2'-yl)-3,5-dimethoxycyclohexa-3,5-dienone and included in the neolignan’s structure category. This compound was reported to have very good biological activity in giving antiproliferative effects on human breast (T47D) cells. From 2.12 g of its leaf methanolic extract, only 12.1 mg of Pc-2 was collected. This amount is too small to do more studies about its biological activities. The synthetic work should be applied to get

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Feldmann, Christian, Dimitar Yonchev, and Jürgen Bajorath. "Structured data sets of compounds with multi-target and corresponding single-target activity from biological assays." Future Science OA 7, no. 5 (2021): FSO685. http://dx.doi.org/10.2144/fsoa-2020-0209.

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Aim: Providing compound data sets for promiscuity analysis with single-target (ST) and multi-target (MT) activity, taking confirmed inactivity against targets into account. Methodology: Compounds and target annotations are extracted from screening assays. For a given combination of targets, MT and ST compounds are identified, ensuring test data completeness. Exemplary results & data: A total of 1242 MT compounds active against five or more targets and 6629 corresponding ST compounds are characterized, organized and made freely available. Limitations & next steps: Screening campaigns ty

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Lumbiny, Bilkis Jahan, Zhang Hui, and M. Azizul Islam. "Antiaging, antioxidant flavonoids; synthesis, antimicrobial screening as well as 3D QSAR CoMFA models for the prediction of biological activity." Journal of the Asiatic Society of Bangladesh, Science 39, no. 2 (2014): 191–99. http://dx.doi.org/10.3329/jasbs.v39i2.17856.

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Flavonoids, polyphenolic heteronuclear compounds which are naturally occurring antioxidants are widely used as antiaging substances. Synthesis of new naturally occuring organic compounds with basic skeleton of chalcones, flavones and oxygenated flavones and their antimicrobial activity were reported by this research group for long. Presently comparative molecular field analysis (CoMFA) implemented in Sybyl 7.3 was conducted on a series of substituted flavones. CoMFA is an effective computer implemented 3D QSAR technique deriving a correlation between set of the biologically active molecules an

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Alanazi, Mohammed M., Saleh Aldawas, and Nawaf A. Alsaif. "Design, Synthesis, and Biological Evaluation of 2-Mercaptobenzoxazole Derivatives as Potential Multi-Kinase Inhibitors." Pharmaceuticals 16, no. 1 (2023): 97. http://dx.doi.org/10.3390/ph16010097.

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A series of 12 compounds was designed and synthesized, based on 2-mercaptobenzoxazole derivatives containing either the substituted benzenes 4a–d, substituted isatins 5a–f, or heterocycles 6a–b. The in vitro antiproliferative activity of the compounds was evaluated against hepatocellular carcinoma (HepG2), mammary gland cancer (MCF-7), breast cancer (MDA-MB-231), and the epithelioid cervix carcinoma (HeLa) cancer cell lines. Compounds 4b, 4d, 5d, and 6b had the most potent antiproliferative activity, with IC50 values ranging from 2.14 to 19.34 µM, compared to the reference drugs, doxorubicin a

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Khan, Ghouse, Swamy Sreenivasa, Shivaraja Govindaiah, and Vivek Chandramohan. "Benzyl and Sulfonyl Derivatives of N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide (T2288): Biological Screening and Fingerprint applications." Oriental Journal of Chemistry 35, no. 1 (2019): 157–66. http://dx.doi.org/10.13005/ojc/350117.

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A series of five N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide (T2288) sulfonamides 6a-e and its five alkylated piperazine derivatives 8a-e have been synthesized, characterized and screened for antibacterial, antifungal and anthelmintic activity. Some of the compounds showed significant biological activities. Molecular docking to crystal structures of target proteins revealed that, active compounds show similar binding poses as that of standards, indicating good correlation of the binding energy with observed invitro data for the active compounds. Finally, the study of latent fingerprint

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