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Dissertations / Theses on the topic 'Biosensor label-free'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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1

Li, Bing. "Graphene transistors for label-free biosensing." Thesis, University of Plymouth, 2016. http://hdl.handle.net/10026.1/5291.

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The discovery of monolayer graphene by Manchester group has led to intensive research into a variety of applications across different disciplines. As a monolayer of carbon atoms, graphene presents a high surface to volume ratio and a good electronic conductivity, making it sensitive to its surface bio-chemical environment. This project investigated the fabrication of electronic biosensors using different graphene-based materials. It included the production of graphene, the fabrication of electronic devices, the chemical functionalisation of graphene surface and the specific detection of target

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Namhil, Zahra Ghobaei. "Nanogap capacitive biosensor for label-free aptamer-based protein detection." Thesis, University of Hull, 2018. http://hydra.hull.ac.uk/resources/hull:16463.

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Recent advances in nanotechnology offer a new platform for the label free detection of biomolecules at ultra-low concentrations. Nano biosensors are emerging as a powerful method of improving device performance whilst minimizing device size, cost and fabrication times. Nanogap capacitive biosensors are an excellent approach for detecting biomolecular interactions due to the ease of measurement, low cost equipment needed and compatibility with multiplex formats. This thesis describes research into the fabrication of a nanogap capacitive biosensor and its detection results in label-free aptamer-

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Stagni, degli Esposti Claudio <1977&gt. "Electronic biosensor arrays for label-free DNA and protein analysis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/408/1/Phd_thesis_ClaudioStagni.pdf.

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Stagni, degli Esposti Claudio <1977&gt. "Electronic biosensor arrays for label-free DNA and protein analysis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/408/.

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5

ZECCA, DAVIDE. "Label-free photonic crystal technology for immunosensing applications." Doctoral thesis, Politecnico di Torino, 2016. http://hdl.handle.net/11583/2645208.

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The continue request in medical field of methods for the diagnosing and the monitoring of diffuse pathologies like cancer, Alzheimer and muscular dystrophy, has pushed the scientific research to focus its interest in he design of biosensors for fast and in-situ assays. Although several typology of biosensors has been proposed, label-free immunosensors are good candidates in the biomarkers detection thanks to a high bio-selective recognition and a simple read-out. This thesis presents the research activity about the design, fabrication and testing of an immunosensor based on a Si3N4 2-D photo

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Ho, M. Y. "An investigation of redox self-assembled monolayer in label-free biosensor application." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604101.

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This dissertation investigates a label-free sensing platform which can be used to detect DNA, enzyme or protein, based upon electrochemical detection which is suitable for implementation in microarray form. Two implementations are proposed based on mixed Ferrocene self-assembled monolayer (SAM) and the Azurin (metalloprotein) SAM. We have shown for the first time that electro-active SAM, functionalized with suitable receptors, can be employed for the detection of biomolecular interactions. Detection of streptavidin by biotin-functionalized Ferrocene SAM was successfully demonstrated. These res

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7

Mir, Llorente Mònica. "Oligonucleotide Based-Biosensors for Label-Free Electrochemical Protein and DNA Detection." Doctoral thesis, Universitat Rovira i Virgili, 2006. http://hdl.handle.net/10803/8542.

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In the last years, DNA arrays have attracted increasing attention among medical diagnosis and analytical chemists. The broad range of application that has been found for DNA arrays makes them an important analytical tool. DNA arrays are relevant for the diagnosis of genetic diseases, detection of infectious agents, study of genetic predisposition, development of a personalised medicine, detection of differential genetic expression, forensic science, drug screening, food safety and environmental monitoring.<br/>Despite the great promise of DNA arrays in health care and their success in medica

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Wang, Yunmiao. "Microgap Structured Optical Sensor for Fast Label-free DNA Detection." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/32875.

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DNA detection technology has developed rapidly due to its extensive application in clinical diagnostics, bioengineering, environmental monitoring, and food science areas. Currently developed methods such as surface Plasmon resonance (SPR) methods, fluorescent dye labeled methods and electrochemical methods, usually have the problems of bulky size, high equipment cost and time-consuming algorithms, so limiting their application for in vivo detection. In this work, an intrinsic Fabry-Perot interferometric (IFPI) based DNA sensor is presented with the intrinsic advantages of small size, low cost

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CANTALE, Vera. "Towards label-free biosensors based on localized surface plasmon resonance." Doctoral thesis, Università degli studi di Ferrara, 2011. http://hdl.handle.net/11392/2388765.

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Medical diagnostics is in constant search of new tools and devices able to provide in short time, accurate and versatile tests performed on patients. Nanotechnology has contributed largely in developing biosensors of smaller size at a lower cost by using a minimal amount of sample. Biosensors aim to monitor and diagnosticate “in situ” the patient status and the diseases caused by alteration of the body metabolism by, for example, the detection of gene mutations, alteration of gene expression or alteration of proteins. The aim of this work is the development of biosensors that satisfy the

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García, Castelló Javier. "A Novel Approach to Label-Free Biosensors Based on Photonic Bandgap Structures." Doctoral thesis, Universitat Politècnica de València, 2014. http://hdl.handle.net/10251/35398.

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The necessity of using extremely high sensitivity biosensors in certain research areas has remarkably increased during the last two decades. Optical structures, where light is used to transduce biochemical interactions into optical signals, are a very interesting approach for the development of this type of biosensors. Within optical sensors, photonic integrated architectures are probably the most promising platform to develop novel lab-on-a-chip devices. Such planar structures exhibit an extremely high sensitivity, a significantly reduced footprint and a high multiplexing potential for sensin

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11

GIOVANARDI, FABIO. "Fibre a nucleo cavo ad accoppiamento inibito per biosensori." Doctoral thesis, Università degli studi di Modena e Reggio Emilia, 2020. http://hdl.handle.net/11380/1200611.

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Negli ultimi decenni, i biosensori hanno suscitato un crescente interesse in diversi settori grazie alle loro particolari caratteristiche biochimiche e la numerosità dei settori potenzialmente coinvolti, che spaziano dal biomedicale all’industria agroalimentare, dalla difesa, alla sicurezza. In letteratura scientifica sono stati studiati svariati tipi di biosensori basati su diversi principi fisici come elettrochimici, ottici e meccanici (sensibili a cambiamenti di massa). Una delle caratteristiche principali richieste dal mercato è che il sensore sia "label-free", ovvero che l'analisi venga

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Sancho, Fornés Gabriel. "Integración de diferentes fenómenos fotónicos en tecnología de disco compacto para el desarrollo de biosensores label-free." Doctoral thesis, Universitat Politècnica de València, 2019. http://hdl.handle.net/10251/124819.

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[ES] En esta tesis se ha abordado el desarrollo de biosensores ópticos label-free, basados en tecnología de disco compacto, permitiendo así abaratar y simplificar su fabricación. El trabajo llevado a cabo ha consistido en estudiar diferentes propiedades físico-químicas desarrolladas por diversos materiales. Ello ha permitido obtener sistemas compactos y accesibles, capaces de sensar con buenas prestaciones analíticas en diferentes escenarios. En el capítulo 1 se presenta un estudio de inhibición enzimática sobre discos Blu-ray como plataforma de ensayo para el cribado de fármacos. Para ello, s

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13

Faria, Henrique Antonio Mendonça. "Biossensores descartáveis de DNA para detecção dos vírus da zika e da dengue." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-05052017-094358/.

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Após setenta anos de sua descoberta, o vírus da zika surgiu no Brasil, espalhou-se rapidamente pelas Américas e trouxe complicações incomuns em doenças causadas por Flavivirus, como a microcefalia. A Organização Mundial da Saúde classifica a zika como a doença viral mais preocupante da atualidade e considera urgente desenvolver novos métodos de diagnóstico para ela e doenças correlatas como a dengue. Embora existam exames para identificar infecções pelos vírus dessas duas doenças, ainda não há um método rápido, específico e de baixo custo para o diagnóstico precoce. Visando preencher essa lacu

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Wang, M. (Meng). "Polymer integrated Young interferometers for label-free biosensing applications." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789514299643.

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Abstract Integrated optical (IO) sensor allowing sensitive, label-free, real-time and multi-parameter monitoring of bio-molecular interactions are conventionally fabricated with inorganic dielectrics inherited from CMOS manufacturing technology. Polymers as complement materials to inorganic dielectrics are becoming to have an increasing market share for IO circuits in optical communications networks owing to its good optical properties, versatile processibility and low cost. This work aims at developing disposable low-cost biosensors based mainly on polymeric materials, with a performance comp

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15

Han, Yinhua. "Label-free detection of biomolecules by a field effect transistor microarray biosensor with bio-functionalized gate surfaces." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982123027.

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16

Mohammed, Kader Hamno. "Development of a label-free biosensor method for the identification of sticky compounds which disturb GPCR-assays." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-220645.

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It is widely known that early estimates about the binding properties of drug candidates are important in the drug discovery process. Surface plasmon resonance (SPR) biosensors have become a standard tool for characterizing interactions between a great variety of biomolecules and it offers a unique opportunity to study binding activity. The aim of this project was to develop a SPR based assay for pre-screening of low molecular weight (LMW) drug compounds, to enable filtering away disturbing compounds when interacting with drugs. The interaction between 47 LMW compounds and biological ligands we

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17

Guo, Xuefei. "Development of Electrochemical Sensors for Biodegradable Metallic Implants and Development of a Label-free Biosensor for Bacteria." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342106824.

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18

Najeeb, Najla. "Design, fabrication and evaluation of a label-free silicon-on-insulator 'Lab on a Chip' optical biosensor." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/45421/.

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This thesis presents the design, fabrication and testing on a Silicon-on-Insulator (SOI) “lab on a chip” immunosensors based on interferometer technology capable of label-free, real time, parallel detection and identification of multiple analytes with extremely high sensitivity. The basic principles for the biosensor device are evanescent wave sensing and interferometry. Light is guided through a high index contrast photonic wire by total internal reflection. The high index contrast core-cladding photonic wires supporting a vector TM-like mode can be designed to have extremely high sensing sen

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19

González, Guerrero Ana Belén. "Bimodal waveguide interferometer device based on silicon photonics technology for label-free and high sensitive biosensing." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/107886.

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Els dispositius òptics biosensors basats en la detecció d’ona evanescent podrien superar les limitacions dels tests de diagnòstic actuals (que són lents i cars) degut a la possibilitat de realitzar les deteccions a temps reals i fent servir un esquema sense la necessitat de marcatges. Entre els diferents transductors òptics, els interferomètrics són els que posseeixen els millors límits de detecció (LOD) deguts a canvis en el índex de refracció de dissolucions (10-7-10-8 Unitats d’Índex de Refracció, RIU) així com per sensibilitat superficial (en el rang dels pg/ml) i un rang lineal més gran.

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20

Khosravi, Farhad. "Carbon nanotubes micro-arrays: characterization and application in biosensing of free proteins and label-free capture of breast cancer cells." Digital WPI, 2016. https://digitalcommons.wpi.edu/etd-dissertations/347.

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"Circulating tumor cells (CTCs) are cells released into the bloodstream from primary tumors and are suspected to be one of the main causes behind metastatic spreading of cancer. The ability to capture and analyze circulating tumor cells in clinical samples is of great interest in prevailing patient prognosis and clinical management of cancer. Carbon nanotubes, individual rolled-up graphene sheets, have emerged as exciting materials for probing the biomolecular interactions. With diameter of about 1 nm, they can attach themselves to cell surface receptors through specific antibodies and hold a

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21

Wang, Xingwei. "Label-free DNA Sequence Detection Using Oligonucleotide Functionalized Fiber Probe with a Miniature Protrusion." Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/28662.

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DNA is the substance that encodes the genetic information that cells need to replicate and to produce proteins. The detection of DNA sequences is of great importance in a broad range of areas including genetics, pathology, criminology, pharmacogenetics, public health, food safety, civil defense, and environmental monitoring. However, the established techniques suffer from a number of problems such as the bulky size, high equipment costs, and time-consuming algorithms so that they are limited to research laboratories and cannot be applied for in-vivo situations. In our research, we developed a

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22

Cansiz, Sena. "Development Of A Sandwich-type Dna Array Platform For The Detection Of Label-free Oligonucleotide Targets." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612658/index.pdf.

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DNA arrays have become a major bioanalytical method as they enable high-throughput screening and they can be manufactured on different surfaces depending on the nature of diagnostic purpose. However, current technologies to produce and detect arrays of DNA probes are expensive due to the requirement of specialized instrumentation. In this study we have established an array platform in sandwich hybridization format for the detection of label-free nucleic acid targets. Unlike direct hybridization, which is the main microarray hybridization principle, sandwich assay enables unlabeled target det

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23

Liu, Chen. "Advanced optical fibre grating sensors for biochemical applications." Thesis, Bangor University, 2019. https://research.bangor.ac.uk/portal/en/theses/advanced-optical-fibre-grating-sensors-for-biochemical-applications(29757d94-bfe1-4d75-a4db-8563be1a056f).html.

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This thesis describes a detailed study of advanced fibre optic sensors and their applications for label-free biochemical detection. The major contributions presented in this thesis are summarised below. A self-assembly based in-situ layer-by-layer (i-LbL) or multilayer deposition technique has been developed to deposit the 2D material nanosheets on cylindrical fibre devices. This deposition technique is based on the chemical bonding associated with the physical adsorption, securing high-quality 2D materials coating on specific fibre cylindrical surface with strong adhesion as well as a prospec

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Mazouzi, Yacine. "Design of label-free immunosensors : from surface functionalization to analyte detection." Electronic Thesis or Diss., Sorbonne université, 2021. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2021SORUS344.pdf.

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La détection rapide d’analytes est cruciale dans la société actuelle, comme l'illustre le développement récent de biocapteurs liés au SARS-Cov2. La conception d’un biocapteur débute par la fonctionnalisation de la surface du transducteur, suivie par la maitrise de l’immobilisation du biorécepteur et enfin la mesure des performances analytique du dispositif final. Dans ce travail, la compréhension fondamentale de l'interface organique-inorganique lors de la première étape de l’élaboration, i.e. : l'adsorption de molécules fonctionnelles à l'interface solide-liquide est d'abord abordée, puis la

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MOI, VALERIA. "Development and Optimization of a Label-free Optical Biosensor Based on Bloch Surface Waves Sustained by One Dimensional Photonic Crystals." Doctoral thesis, Politecnico di Torino, 2015. http://hdl.handle.net/11583/2593366.

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The Ph.D. thesis is focused on the development of a label-free optical biosensor based on the excitation of surface electromagnetic modes, Bloch Surface Waves (BSW), sustained by truncated One Dimensional Photonic Crystal (1DPC). BSWs are electromagnetic modes that can be coupled at the interface between a truncated dielectric 1DPC and a homogeneous external medium, for particular combinations of angle and wavelength of an incoming radiation. These modes are confined on the multilayer surface and propagate in the plane, while the electric field amplitude shows an exponential decay

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bhardwaj, vinay. "Label-free surface-enhanced Raman spectroscopy-linked immunosensor assay (SLISA) for environmental surveillance." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2321.

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The contamination of the environment, accidental or intentional, in particular with chemical toxins such as industrial chemicals and chemical warfare agents has increased public fear. There is a critical requirement for the continuous detection of toxins present at very low levels in the environment. Indeed, some ultra-sensitive analytical techniques already exist, for example chromatography and mass spectroscopy, which are approved by the US Environmental Protection Agency for the detection of toxins. However, these techniques are limited to the detection of known toxins. Cellular expression

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Castagna, Riccardo. "Detection of Angiogenic Growth Factor by Microcantilever Biosensors." Doctoral thesis, Università degli studi di Trieste, 2011. http://hdl.handle.net/10077/4578.

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2009/2010<br>To reach new and relevant insights in biomolecular sciences, new tools for fine and precise measurement are needed. Nowadays advances in the field of micro-electro-mechanical systems (MEMS) offer unique opportunities in the design of ultrasensitive analytical devices to support the molecular sensing investigations. Among them Microcantilever (MC) biosensors are label-free platforms that combine a biologically sensitive with a physical transducer in order to selectively and quantitatively detect the presence of specific compounds in a given external environment. Since they can be

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VANJUR, LUKA. "KINETICS OF NUCLEIC ACIDS HYBRIDIZATION AND OF COMPLEX DNA STRUCTURES FORMATION ON A BIOSENSING SURFACE." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/806961.

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Use of DNA-based molecular probes on a biosensing surface enables unprecedented designs, with nely tuned responsive structures. Furthermore, cost and production of DNA, in addition to its overall ability to interact with various biological molecules, make DNA the ideal candidate for biosensing surface functionalization. However, all DNA based biosensing relies at some point on the pairing of to single stranded DNA molecules, namely DNA hybridization. I utilized a label-free, optical, multiplexed, biosensing platform to study probing capabilities of surface grafted DNA, from simple short

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Ghasemi, Farshid. "Multiplexed label-free integrated photonic biosensors." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/53633.

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Optics and photonics enable important technological solutions for critical areas such as health, communications, energy, and manufacturing. Novel nanofabrication techniques, on the other hand, have enabled the realization of ever shirking devices. On-chip photonic micro-resonators, the fabrication of which was made possible in the recent decade thanks to the progress in nanofabrication, provide a sensitive and scalable transduction mechanism that can be used for biochemical sensing applications. The recognition and quantification of biological molecules is of great interest for a wide range of

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Gandolfi, Davide. "On-chip photonic label-free biosensors." Doctoral thesis, Università degli studi di Trento, 2015. https://hdl.handle.net/11572/368219.

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The development of a highly integrated optical biosensor is expected to significantly impact on the performances and on the throughput of biochemical assays, with applications in the field of pharmaceutical research, point-of-care diagnostic, food-borne pathogens screening and safety. This dissertation studies the development of a label-free on-chip biosensor for the selective detection of Aflatoxin-M1 from milk content. We detail the design and the realization of two types of multiplexed sensors. They are based on the silicon photonics technology and operates in liquid ambient at wavelengths

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Gandolfi, Davide. "On-chip photonic label-free biosensors." Doctoral thesis, University of Trento, 2015. http://eprints-phd.biblio.unitn.it/1452/1/Tesi_PhD_Gandolfi_Davide.pdf.

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The development of a highly integrated optical biosensor is expected to significantly impact on the performances and on the throughput of biochemical assays, with applications in the field of pharmaceutical research, point-of-care diagnostic, food-borne pathogens screening and safety. This dissertation studies the development of a label-free on-chip biosensor for the selective detection of Aflatoxin-M1 from milk content. We detail the design and the realization of two types of multiplexed sensors. They are based on the silicon photonics technology and operates in liquid ambient at wavelengt

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Dong, Jianchun. "Label free electronic detection of biomarkers /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5893.

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Gylfason, Kristinn Björgvin. "Integrated Optical Slot-Waveguide Ring Resonator Sensor Arrays for Lab-on-Chip Applications." Doctoral thesis, KTH, Mikrosystemteknik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-12214.

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This thesis treats the development of an integrated optical sensor array. The sensors are slot-waveguide ring resonators, integrated with on-chip surface grating couplers and light splitters, for alignment tolerant, real-time, refractive index sensing, and label-free biosensing. The work includes: the design of components and system layouts, the development of fabrication methods, the fabrication of sensor chips, the characterization of the chips, and the development of physical system models for accurate extraction of resonance wavelengths in measured spectra. The main scientific achievements

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Dar, T. "Numerical characterisation of label free optical biosensors." Thesis, City University London, 2015. http://openaccess.city.ac.uk/13075/.

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There is a significant need for the development and use of numerical methods to simulate advance and complex optical biosensor structures. Finite Element Method (FEM) has been established as one of the most powerful and versatile numerical method and has been implemented in this thesis to characterize, analyse and optimise label-free optical biosensors for the detection of micron size biological objects like bacteria such as E.coli and nanometre size biomolecules such as antibody, nucleic acids and proteins. These sensors are all suitable for deep-probe sensing as large evanescent field can be

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Zaccari, Irene. "Multiplexed label-free electronic biosensors for clinical diagnostics." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/6893/.

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The development of a highly sensitive, label-free, multiplexed biosensor platform for point-of-care diagnostics is presented. The sensor surface of a non-faradaic electrochemical impedance spectroscopy (EIS) immuno-sensor platform was developed and fully characterised. Optimisation of the binding of monoclonal antibodies (mAb) towards the model target human chorionic gonadotropin (hCG) to the OEG self-assembled monolayers (SAMs) was carried out. Optimal conditions for immobilisation were found for buffer pH approximately one unit below the pI of the antibody. The same condition resulted in bot

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Thompson, Liz. "A label free DNA hybridization sensor." Thesis, Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/26968.

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Brandigampala, Savindra Madhavi. "Label-free electrical immunoassay biosensors for early disease diagnosis." Thesis, Wichita State University, 2012. http://hdl.handle.net/10057/5378.

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This thesis focused on developing an inexpensive and user friendly “point- of- care” (POC) device for early disease diagnosis. Proteomics research has elucidated many new proteins as biomarkers that have the potential to greatly improve disease diagnosis. A combination of several biomarkers has been determined to provide the information necessary for robust diagnosis of a disease in any person within a population. This technology was employed in a clinical application to identify two disease states: (i) vulnerable coronary plaque rupture, which is the cause of acute coronary syndromes stroke;

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Martínez, Pérez Paula. "Development and Optimization of Experimental Biosensing Protocols Using Porous Optical Transducers." Doctoral thesis, Universitat Politècnica de València, 2021. http://hdl.handle.net/10251/172541.

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[ES] Los biosensores son dispositivos analíticos con aplicabilidad en diferentes campos y con numerosas ventajas frente a otros métodos analíticos convencionales, como son el uso de pequeños volúmenes de muestra y reactivos, su sensibilidad y su rápida respuesta, sin necesidad de pretratamiento de la muestra, equipos caros o personal especializado. Sin embargo, se trata de un campo de investigación relativamente nuevo en el que todavía queda mucho camino por andar. Esta Tesis doctoral pretende aportar un granito de arena a este campo de conocimiento mediante el estudio del potencial de dif

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Para, Prashanthi. "FABRICATION OF NANOSTRUCTURES FOR IMPROVED PERFORMANCE OF ELECTROCHEMICAL SENSORS AND FOR REFERENCE COMPENSATION IN LOCALIZED SURFACE PLASMON RESONANCE SENSORS." UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_theses/130.

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L‐glutamate is associated with several neurological disorders; thus, monitoring fast dynamics of L‐glutamate is of great importance in the field of neuroscience. Electrode miniaturization demanded by many applications leads to reduced surface area and decreased amounts of immobilized enzymes on coated electrodes. As a result, lower signal‐to‐noise ratios are observed for oxidase‐enzyme based sensors. To increase the signal‐to‐noise ratio we have developed a process to fabricate micro‐ and nano‐ structures on the microelectrode surface. Localized surface‐plasmon resonances (SPR) has been extens

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Salazar, Soto Arnoldo. "Conception d'un imageur CMOS à colonne active pour un biocapteur optique SPR." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENT063/document.

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Cette thèse présente la conception et la mise en œuvre d'un imageur CMOS pour être utilisé dans biocapteurs intégrés basés sur Résonance Plasmonique de Surface (SPR). Tout d'abord, les conditions optimales pour la résonance plasmon dans une interface compatible CMOS / post-CMOS sont obtenus par modélisation avec COMSOL. Deuxièmement, un imageur CMOS de Colonne Actif (CMOS-ACS) du 32x32 pixels est mis en œuvre sur une technologie CMOS 0,35 um. Dans une interface d'or-eau avec une excitation de prisme, on constate que pour les prismes avec des indices de réfraction de 1,55 et 1,46, le couplage o

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Lanfranco, R. "OPTICAL DETECTION OF MOLECULAR INTERACTIONS ON THE SURFACE OF MATERIALS INDEX-MATCHED TO WATER." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/378031.

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The idea to have highly effective autonomous sensors able to measure and share information about the quality of our environment, and particularly water, in our lakes and rivers, our water supply system and the outputs of municipal and industrial wastewater treatment systems is revolutionary and fascinating. These sensors could be densely deployed at multiple locations, and the information may be available to citizens through the Internet. This idyllic vision, nowadays, is far away from being reality, despite the huge effort made to develop innovative molecular sensors. The main challenge

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Ahn, Sunmin. "Performance improvement of label-free biosensors and their applications in DNA and protein microarrays." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12706.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Microarray technologies have provided powerful tools in modem biotechnology to decipher the complex interconnectivity of genetic and regulatory network. Label-free biosensors have emerged as competitive technol

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Zafﬁno, Rosa Letizia. "Development of a nano sensor for direct-electric free-label detection of DNA’s hybridization and single nucleotide polymorphism." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/384708.

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The search for analytical tools suitable for wide-scale application of DNA analysis is an hot research topic, although thanks to well-established microarray based technology, analysis of DNA sequences and SNP detection can be worked out through a fairly laboratory routine. DNA analysis has nowadays become of increasing interest for several different purposes, mainly thanks to the successful employment of microarray technology, characterized by high sensitiveness and high-throughput analysis, which rapidly advanced genetics leading to devel- opment of many fields of application of DNA analy

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Afonin, Kirill A. "Design and characterization of novel bio-sensor platform for sequence specific, label-free, fluorescent detection of native RNA molecules." Bowling Green, Ohio : Bowling Green State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1206395144.

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Combs, Zachary Allen. "Advanced substrate design for label-free detection of trace organic and biological molecules." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/50314.

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To truly realize and exploit the extremely powerful information given from surface-enhanced Raman scattering (SERS) spectroscopy, it is critical to develop an understanding of how to design highly sensitive and selective substrates, produce specific and label-free spectra of target analytes, and fabricate long-lasting and in-the-field ready platforms for trace detection applications. The study presented in this dissertation investigated the application of two- and three-dimensional substrates composed of highly-ordered metal nanostructures. These systems were designed to specifically detect

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Afonin, Kirill A. "Design and Characterization of Novel Bio-Sensor Platform for Sequence Specific, Label-Free, Fluorescent Detection of Native RNA Moledcules." Bowling Green State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1206395144.

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Bronder, Thomas Stefan [Verfasser], and Michael J. [Akademischer Betreuer] Schöning. "Label-free detection of tuberculosis DNA with capacitive field-effect biosensors / Thomas Stefan Bronder ; Betreuer: Michael J. Schöning." Marburg : Philipps-Universität Marburg, 2021. http://d-nb.info/1226287395/34.

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Nguyen, Thanh Chien [Verfasser], Andreas [Akademischer Betreuer] König, and Sven [Akademischer Betreuer] Ingebrandt. "Readout Concepts for Label-Free Biomolecule Detection with Advanced ISFET and Silicon Nanowire Biosensors / Thanh Chien Nguyen ; Andreas König, Sven Ingebrandt." Kaiserslautern : Technische Universität Kaiserslautern, 2018. http://d-nb.info/1154765415/34.

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Estrada, Leypón Oscar Emilio. "Micro-Nano-Bio Systems for on-line monitoring of in vitro biofilm responses." Doctoral thesis, Universitat Ramon Llull, 2015. http://hdl.handle.net/10803/300595.

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El treball presentat en aquesta tesi doctoral te com objectiu principal la contribució en el camp de la microbiologia per entendre el biofilms i el possible control de desenvolupament mitjançant l’ús de mètodes i enfoc multidisciplinari. Els biofilms estan definits com comunitats de microorganismes que creixen envoltats en una matriu exopolisacárida i s’adhereixen a una superfície inert o teixit viu. La formació dels biofilms bacterians tenen un gran interès en microbiologia clínica degut al desenvolupament d’infeccions que son causades pel contacte directe o per colonització de dispositius mè

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Gao, Shiuan-Huei, and 高炫揮. "Label-free and real-time protein biosensor." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/70401169843752291048.

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