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Journal articles on the topic 'Biosensor label-free'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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1

Rho, Donggee, Caitlyn Breaux, and Seunghyun Kim. "Label-Free Optical Resonator-Based Biosensors." Sensors 20, no. 20 (2020): 5901. http://dx.doi.org/10.3390/s20205901.

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The demand for biosensor technology has grown drastically over the last few decades, mainly in disease diagnosis, drug development, and environmental health and safety. Optical resonator-based biosensors have been widely exploited to achieve highly sensitive, rapid, and label-free detection of biological analytes. The advancements in microfluidic and micro/nanofabrication technologies allow them to be miniaturized and simultaneously detect various analytes in a small sample volume. By virtue of these advantages and advancements, the optical resonator-based biosensor is considered a promising p

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Srinivas, Burra. "Simulation Study of Dielectric Modulated Dual Material Gate TFET Based Biosensor." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 09, no. 05 (2025): 1–9. https://doi.org/10.55041/ijsrem49228.

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ABSTRACT - This study focuses on the simulation and modeling of Tunnel Field-Effect Transistor (TFET) based biosensors for label-free detection of biomolecules. TFET biosensors offer high sensitivity and selectivity, making them promising for biomedical applications. Our simulation and modeling approach aims to optimize TFET biosensor design, improve detection accuracy, and reduce development time. We investigate the impact of various design parameters on biosensor performance and explore the potential of TFET biosensors for real-world applications. This research contributes to the development

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Zhang, Pengfei, and Rui Wang. "Label-Free Biosensor." Biosensors 13, no. 5 (2023): 556. http://dx.doi.org/10.3390/bios13050556.

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Label-free biosensors have become an indispensable tool for analyzing intrinsic molecular properties, such as mass, and quantifying molecular interactions without interference from labels, which is critical for the screening of drugs, detecting disease biomarkers, and understanding biological processes at the molecular level [...]

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Reuter, Cornelia, Walter Hauswald, Sindy Burgold-Voigt, et al. "Imaging Diffractometric Biosensors for Label-Free, Multi-Molecular Interaction Analysis." Biosensors 14, no. 8 (2024): 398. http://dx.doi.org/10.3390/bios14080398.

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Biosensors are used for the specific and sensitive detection of biomolecules. In conventional approaches, the suspected target molecules are bound to selected capture molecules and successful binding is indicated by additional labelling to enable optical readout. This labelling requires additional processing steps tailored to the application. While numerous label-free interaction assays exist, they often compromise on detection characteristics. In this context, we introduce a novel diffractometric biosensor, comprising a diffractive biosensor chip and an associated optical reader assembly. Thi

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Janssen, Jesslyn, Mike Lambeta, Paul White, and Ahmad Byagowi. "Carbon Nanotube-Based Electrochemical Biosensor for Label-Free Protein Detection." Biosensors 9, no. 4 (2019): 144. http://dx.doi.org/10.3390/bios9040144.

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There is a growing need for biosensors that are capable of efficiently and rapidly quantifying protein biomarkers, both in the biological research and clinical setting. While accurate methods for protein quantification exist, the current assays involve sophisticated techniques, take long to administer and often require highly trained personnel for execution and analysis. Herein, we explore the development of a label-free biosensor for the detection and quantification of a standard protein. The developed biosensors comprise carbon nanotubes (CNTs), a specific antibody and cellulose filtration p

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Lai, Meimei, and Gymama Slaughter. "Label-Free MicroRNA Optical Biosensors." Nanomaterials 9, no. 11 (2019): 1573. http://dx.doi.org/10.3390/nano9111573.

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MicroRNAs (miRNAs) play crucial roles in regulating gene expression. Many studies show that miRNAs have been linked to almost all kinds of disease. In addition, miRNAs are well preserved in a variety of specimens, thereby making them ideal biomarkers for biosensing applications when compared to traditional protein biomarkers. Conventional biosensors for miRNA require fluorescent labeling, which is complicated, time-consuming, laborious, costly, and exhibits low sensitivity. The detection of miRNA remains a big challenge due to their intrinsic properties such as small sizes, low abundance, and

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Choudhury, Sagarika, Krishna Lal Baishnab, Koushik Guha, Zoran Jakšić, Olga Jakšić, and Jacopo Iannacci. "Modeling and Simulation of a TFET-Based Label-Free Biosensor with Enhanced Sensitivity." Chemosensors 11, no. 5 (2023): 312. http://dx.doi.org/10.3390/chemosensors11050312.

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This study discusses the use of a triple material gate (TMG) junctionless tunnel field-effect transistor (JLTFET) as a biosensor to identify different protein molecules. Among the plethora of existing types of biosensors, FET/TFET-based devices are fully compatible with conventional integrated circuits. JLTFETs are preferred over TFETs and JLFETs because of their ease of fabrication and superior biosensing performance. Biomolecules are trapped by cavities etched across the gates. An analytical mathematical model of a TMG asymmetrical hetero-dielectric JLTFET biosensor is derived here for the f

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Saha, Soumyadeep, Manoj Sachdev, and Sushanta K. Mitra. "Recent advances in label-free optical, electrochemical, and electronic biosensors for glioma biomarkers." Biomicrofluidics 17, no. 1 (2023): 011502. http://dx.doi.org/10.1063/5.0135525.

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Gliomas are the most commonly occurring primary brain tumor with poor prognosis and high mortality rate. Currently, the diagnostic and monitoring options for glioma mainly revolve around imaging techniques, which often provide limited information and require supervisory expertise. Liquid biopsy is a great alternative or complementary monitoring protocol that can be implemented along with other standard diagnosis protocols. However, standard detection schemes for sampling and monitoring biomarkers in different biological fluids lack the necessary sensitivity and ability for real-time analysis.

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Angelopoulou, Michailia, Sotirios Kakabakos, and Panagiota Petrou. "Label-Free Biosensors Based onto Monolithically Integrated onto Silicon Optical Transducers." Chemosensors 6, no. 4 (2018): 52. http://dx.doi.org/10.3390/chemosensors6040052.

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The article reviews the current status of label-free integrated optical biosensors focusing on the evolution over the years of their analytical performance. At first, a short introduction to the evanescent wave optics is provided followed by detailed description of the main categories of label-free optical biosensors, including sensors based on surface plasmon resonance (SPR), grating couplers, photonic crystals, ring resonators, and interferometric transducers. For each type of biosensor, the detection principle is first provided followed by description of the different transducer configurati

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O'Malley, Shawn M., Xinying Xie, and Anthony G. Frutos. "Label-Free High-Throughput Functional Lytic Assays." Journal of Biomolecular Screening 12, no. 1 (2006): 117–25. http://dx.doi.org/10.1177/1087057106296496.

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Refractive index-sensitive resonant waveguide grating biosensors are used to assay the label-free enzymatic degradation of biomolecules. These assays provide a robust means of screening for functional lytic modulators. The biomolecular substrates in this study were covalently immobilized through amine groups. Using the Corning® Epic™ System, the digestion signatures for multiple protein substrates on the biosensors are measured. Label-free digestion profiles for these proteins were substrate specific. Similarly, the authors find that the label-free digestion is protease specific. Enzyme-substr

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Koyappayil, Aneesh, and Min-Ho Lee. "Ultrasensitive Materials for Electrochemical Biosensor Labels." Sensors 21, no. 1 (2020): 89. http://dx.doi.org/10.3390/s21010089.

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Since the fabrication of the first electrochemical biosensor by Leland C. Clark in 1956, various labeled and label-free sensors have been reported for the detection of biomolecules. Labels such as nanoparticles, enzymes, Quantum dots, redox-active molecules, low dimensional carbon materials, etc. have been employed for the detection of biomolecules. Because of the absence of cross-reaction and highly selective detection, labeled biosensors are advantageous and preferred over label-free biosensors. The biosensors with labels depend mainly on optical, magnetic, electrical, and mechanical princip

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Orlov, Alexey V., Maria O. Zolotova, Denis O. Novichikhin, et al. "Stannous Chloride-Modified Glass Substrates for Biomolecule Immobilization: Development of Label-Free Interferometric Sensor Chips for Highly Sensitive Detection of Aflatoxin B1 in Corn." Biosensors 14, no. 11 (2024): 531. http://dx.doi.org/10.3390/bios14110531.

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This study presents the development of stannous chloride (SnCl2)-modified glass substrates for biomolecule immobilization and their application in fabricating sensor chips for label-free interferometric biosensors. The glass modification process was optimized, identifying a 5% SnCl2 concentration, a 45 min reaction time, and a 150 °C drying temperature as conditions for efficient protein immobilization. Based on the SnCl2-modified glass substrates and label-free spectral-phase interferometry, a biosensor was developed for the detection of aflatoxin B1 (AFB1)—a highly toxic and carcinogenic con

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M. Shaifullah A. S, J. Jumat, M. N. M. Nuzaihan, et al. "Silicon Nanowire Biosensors for Diabetes Mellitus Monitoring." International Journal of Nanoelectronics and Materials (IJNeaM) 17, no. 4 (2024): 499–509. http://dx.doi.org/10.58915/ijneam.v17i4.1276.

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The main goal of this research is the development of a label-free biosensor for the detection of diabetes mellitus (DM) using the target molecule retinol-binding protein 4 (RBP4). The enzyme-linked immunosorbent assay (ELISA) approach, currently used to detect DM, is time-consuming and difficult. As a result, label-free biosensors are being considered as an alternative. In this research, silicon nanowires (SiNWs) were selected as the transducer for this biosensor due to their low cost, real-time analysis capability, high sensitivity, and low detection limit. The SiNWs were created using conven

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Luka, George, Ehsan Samiei, Soroush Dehghani, Thomas Johnson, Homayoun Najjaran, and Mina Hoorfar. "Label-Free Capacitive Biosensor for Detection of Cryptosporidium." Sensors 19, no. 2 (2019): 258. http://dx.doi.org/10.3390/s19020258.

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Cryptosporidium, an intestinal protozoan pathogen, is one of the leading causes of diarrhea in healthy adults and death in children. Detection of Cryptosporidium oocysts has become a high priority to prevent potential outbreaks. In this paper, a label-free interdigitated-based capacitive biosensor has been introduced for the detection of Cryptosporidium oocysts in water samples. Specific anti-Cryptosporidium monoclonal antibodies (IgG3) were covalently immobilized onto interdigitated gold electrodes as the capture probes, and bovine serum albumin was used to avoid non-specific adsorption. The

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Savas, Sumeyra, and Melike Sarıçam. "A Novel PCR-Free Ultrasensitive GQD-Based Label-Free Electrochemical DNA Sensor for Sensitive and Rapid Detection of Francisella tularensis." Micromachines 15, no. 11 (2024): 1308. http://dx.doi.org/10.3390/mi15111308.

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Biological warfare agents are infectious microorganisms or toxins capable of harming or killing humans. Francisella tularensis is a potential bioterrorism agent that is highly infectious, even at very low doses. Biosensors for biological warfare agents are simple yet reliable point-of-care analytical tools. Developing highly sensitive, reliable, and cost-effective label-free DNA biosensors poses significant challenges, particularly when utilizing traditional techniques such as fluorescence, electrochemical methods, and others. These challenges arise primarily due to the need for labeling, enzy

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Konoplev, Georgii, Darina Agafonova, Liubov Bakhchova, et al. "Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures." Biomedicines 10, no. 2 (2022): 207. http://dx.doi.org/10.3390/biomedicines10020207.

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Proteins in biological fluids (blood, urine, cerebrospinal fluid) are important biomarkers of various pathological conditions. Protein biomarkers detection and quantification have been proven to be an indispensable diagnostic tool in clinical practice. There is a growing tendency towards using portable diagnostic biosensor devices for point-of-care (POC) analysis based on microfluidic technology as an alternative to conventional laboratory protein assays. In contrast to universally accepted analytical methods involving protein labeling, label-free approaches often allow the development of bios

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Nikitin, P. I., B. G. Gorshkov, E. P. Nikitin, and T. I. Ksenevich. "Picoscope, a new label-free biosensor." Sensors and Actuators B: Chemical 111-112 (November 2005): 500–504. http://dx.doi.org/10.1016/j.snb.2005.03.043.

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Li, Ming. "(Invited) Paper-Based SERS Quantitative Analysis for Cancer Diagnosis and Subtyping." ECS Meeting Abstracts MA2023-02, no. 63 (2023): 2969. http://dx.doi.org/10.1149/ma2023-02632969mtgabs.

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Paper-based biosensors are typically low-cost and user-friendly, which enable fast and easy detection of biomarkers of pathological significance for disease point-of-care diagnosis and therapeutic monitoring. Quantitative analysis of biomarkers in body fluids provides a good opportunity for early diagnosis, prompt treatment and longitudinal therapeutic surveillance of diseases such as cancer. Surface-enhanced Raman spectroscopy (SERS) is a powerful spectroscopic analytical technique capable of ultrasensitive and nondestructive analysis of biomarkers directly in biological samples with a multit

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Sierpe, Rodrigo, Marcelo J. Kogan, and Soledad Bollo. "Label-Free Oligonucleotide-Based SPR Biosensor for the Detection of the Gene Mutation Causing Prothrombin-Related Thrombophilia." Sensors 20, no. 21 (2020): 6240. http://dx.doi.org/10.3390/s20216240.

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Prothrombin-related thrombophilia is a genetic disorder produced by a substitution of a single DNA base pair, replacing guanine with adenine, and is detected mainly by polymerase chain reaction (PCR). A suitable alternative that could detect the single point mutation without requiring sample amplification is the surface plasmon resonance (SPR) technique. SPR biosensors are of great interest: they offer a platform to monitor biomolecular interactions, are highly selective, and enable rapid analysis in real time. Oligonucleotide-based SPR biosensors can be used to differentiate complementary seq

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Umar, Ahmad, Mazharul Haque, Shafeeque G. Ansari, et al. "Label-Free Myoglobin Biosensor Based on Pure and Copper-Doped Titanium Dioxide Nanomaterials." Biosensors 12, no. 12 (2022): 1151. http://dx.doi.org/10.3390/bios12121151.

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In this study, using pure and copper-doped titanium dioxide (Cu-TiO2) nanostructures as the base matrix, enzyme-less label free myoglobin detection to identify acute myocardial infarction was performed and presented. The Cu-TiO2 nanomaterials were prepared using facile sol–gel method. In order to comprehend the morphologies, compositions, structural, optical, and electrochemical characteristics, the pure and Cu-TiO2 nanomaterials were investigated by several techniques which clearly revealed good crystallinity and high purity. To fabricate the enzyme-less label free biosensor, thick films of s

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Shi, Ya Min, Guo Guang Rong, Dan Ni Wang, Shu Lin Zhang, and Yong Xin Zhu. "A Label-Free Biosensor Based on Nanoscale Porous Silicon Thin Film for Tuberculosis Detection." Advanced Materials Research 1082 (December 2014): 555–61. http://dx.doi.org/10.4028/www.scientific.net/amr.1082.555.

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Though techniques in medicine develop in a very fast pace, tuberculosis still bothers researchers for its extensive existence. It is urgent to find faster, cheaper and more convenient new ways for diagnosis of tuberculosis. In this paper, we demonstrated a novel serodiagnostic method based on porous silicon thin film. Porous silicon has been proven feasible to function as biosensors in a lot of research. While most serodiagnostic methods are labeled detection, our porous silicon biosensor is a label-free technique. This kind of biosensor is manufactured in a simple way with relatively lower co

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Ivanova, Nataliia, Soha Ahmadi, Edmund Chan, Léa Fournier, Sandro Spagnolo, and Michael Thompson. "Detection of Ovarian Cancer Biomarker Lysophosphatidic Acid Using a Label-Free Electrochemical Biosensor." Electrochem 5, no. 2 (2024): 243–57. http://dx.doi.org/10.3390/electrochem5020015.

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Electrochemical biosensors are valued for their sensitivity and selectivity in detecting biological molecules. Having the advantage of generating signals that can be directly or indirectly proportional to the concentration of the target analyte, these biosensors can achieve specificity by utilizing a specific biorecognition surface designed to recognize the target molecule. Electrochemical biosensors have garnered substantial attention, as they can be used to fabricate compact, cost-effective devices, making them promising candidates for point-of-care testing (POCT) devices. This study introdu

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García-Milán, Víctor, Alfredo Franco, Margarita Estreya Zvezdanova, et al. "INNV-05. DEVELOPMENT OF A LABEL-FREE PLASMONIC OPTICAL BIOSENSOR FOR INTRAOPERATIVE DETECTION OF TUMOR TISSUE IN GLIOBLASTOMA." Neuro-Oncology 26, Supplement_8 (2024): viii169—viii170. http://dx.doi.org/10.1093/neuonc/noae165.0668.

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Abstract Safe maximal resection of patients with glioblastoma remains a surgical challenge due to the invasive nature of the tumor and the difficulty in distinguishing tumor margins during resection. Several tools are currently used for this purpose, such as, confocal laser endomicroscopy and fluorescence-guided surgery. In this context, biosensors based on plasmonic technology using the extraordinary optical transmission (EOT) phenomenon can help to distinguish between tumor and surrounding tissue based on their optical properties. We developed a biosensor utilizing EOT through a nanostructur

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Jerinsajeev, C. R., and Herobin Rani A. Sheeja. "Analyzing performance free biosensor utilizing a split- gate t-shape and modeling of a label-channel design with DM DPDG-TFET technology." i-manager's Journal on Circuits and Systems 12, no. 2 (2024): 29. https://doi.org/10.26634/jcir.12.2.21508.

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This paper introduces a novel split gate T-shape channel dielectrically modulated (DM) double-gate tunnel field-effect transistor (DGTFET) with a drain pocket (DP), proposing its application as a label-free biosensor. Through the development and validation of an analytical model using Silvaco TCAD simulation software, the focus is on both the biosensor's sensitivity and its performance as a TFET device. By innovatively shaping the channel, the device demonstrates improved sensitivity, a higher ION/IOFF current ratio, and a reduced sub threshold slope. Notably, the inclusion of the drain pocket

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Shao, Long, Biyu Zhang, Wei Wu, Gengyan Cui, and Mao Liu. "A Label-Free Photoelectrochemical Biosensor Based on ZnO/Cs3MnBr5 Heterogeneous Films for Alpha-Fetoprotein Detection." Nanomaterials 14, no. 13 (2024): 1127. http://dx.doi.org/10.3390/nano14131127.

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Highly sensitive and specific biomarker detection is of outstanding importance for the diagnosis and treatment of cancers. Herein, we developed robust photoelectrochemical (PEC) biosensors with low background noise and high sensitivity based on a heterojunction, which can improve semiconductor photoelectric properties by limiting the recombination of photogenerated electron–hole pairs and successfully widening the range of light absorption. Alpha-fetoprotein (AFP) was used as a target model to examine the analytical performances of the designed PEC biosensors. ZnO/Cs3MnBr5 heterogeneous film w

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Liyanage, Thakshila, Meimei Lai, and Gymama Slaughter. "Label-free tapered optical fiber plasmonic biosensor." Analytica Chimica Acta 1169 (July 2021): 338629. http://dx.doi.org/10.1016/j.aca.2021.338629.

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Frutiger, Andreas, Karl Gatterdam, Yves Blickenstorfer, Andreas Michael Reichmuth, Christof Fattinger, and János Vörös. "Ultra Stable Molecular Sensors by Submicron Referencing and Why They Should Be Interrogated by Optical Diffraction—Part II. Experimental Demonstration." Sensors 21, no. 1 (2020): 9. http://dx.doi.org/10.3390/s21010009.

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Label-free optical biosensors are an invaluable tool for molecular interaction analysis. Over the past 30 years, refractometric biosensors and, in particular, surface plasmon resonance have matured to the de facto standard of this field despite a significant cross reactivity to environmental and experimental noise sources. In this paper, we demonstrate that sensors that apply the spatial affinity lock-in principle (part I) and perform readout by diffraction overcome the drawbacks of established refractometric biosensors. We show this with a direct comparison of the cover refractive index jump

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Dalmay, Claire, Arnaud Pothier, Mathilde Cheray, Fabrice Lalloue, Marie-Odile Jauberteau, and Pierre Blondy. "Label-free RF biosensors for human cell dielectric spectroscopy." International Journal of Microwave and Wireless Technologies 1, no. 6 (2009): 497–504. http://dx.doi.org/10.1017/s1759078709990614.

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This paper presents an original biosensor chip allowing determination of intrinsic relative permittivity of biological cells at microwave frequencies. This sensor permits non-invasive cell identification and discrimination using an RF signal to probe intracellular medium of biological samples. Indeed, these sensors use an RF planar resonator that allows detection capabilities on less than 10 cells, thanks to the microscopic size of its sensitive area. Especially, measurements between 15 and 35 GHz show the ability label-free biosensors to differentiate two human cell types using their own elec

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Raghav, Pooja, Manisha Bharti, and Neha Paras. "Detection of Herpes Biomolecule using Ge-based Dielectrically Modulated TFET." International Journal of Microsystems and IoT 2, no. 10 (2024): 1246–53. https://doi.org/10.5281/zenodo.14167709.

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In this, dielectrically modulated TFET architecture based on Germanium is proposed for label-free detection of herpes virus. Comprehensive numerical device simulations performed on Silvaco 2D TCAD tool are used to study the performance of these biosensor. By altering the gate voltage, the effectiveness of this biosensor is evaluated based on current sensitivity. This paper will primarily focus on examining the biosensor's sensitivity and performance of a tunnel field-effect transistor (TFET) device. A detailed analysis of the device's ON current, OFF current and subthreshold swing has been con

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Ebrahimi, Aida. "(Invited) Electrochemical Biosensors for Label-Free Bacterial Analysis." ECS Meeting Abstracts MA2022-01, no. 53 (2022): 2203. http://dx.doi.org/10.1149/ma2022-01532203mtgabs.

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Traditional methods for bacterial detection and analysis are time consuming, labor-demanding, and have limited portability. This presents a significant opportunity for biosensor engineers to develop low-cost devices for bacterial studies. In this talk, I will discuss our recent advances in developing electrochemical biosensing devices for bacterial analysis. The devices enable characterizing cell envelope, metabolic activity, and quorum sensing molecules, and can provide real-time insight into bacterial response to environmental stress, such as drugs. The sensors feature functional materials t

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Olukotun, Ibukunoluwa Fikayo, Akuchinyere Onyinyechukwu Titus-Okpanachi, Rachael Taiwo Tiamiyu, and Ehinomhen Inegbedion. "Development of a Label-Free Electrochemical Biosensor for Early Detection of Neurodegenerative Disease Biomarkers." International Journal of Medical and All Body Health Research 6, no. 2 (2025): 61–66. https://doi.org/10.54660/ijmbhr.2025.6.2.61-66.

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Early diagnosis of neurodegenerative diseases (NDs) such as Alzheimer’s (AD) and Parkinson’s (PD) is critically dependent on detecting specific protein biomarkers at very low concentrations. This study presents the design, fabrication, and characterization of a novel label-free electrochemical biosensor for ultrasensitive detection of key ND biomarkers (β-amyloid (Aβ), tau, and α-synuclein). A glassy carbon electrode (GCE) was modified with a nanocomposite of carboxyl graphene (CG), thionin, and electrodeposited Au nanoparticles (AuNPs) to immobilize a specific aptamer against tau protein. Ele

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Vora, Kunj, Norbert Kordas, and Karsten Seidl. "Label-Free, Impedance-Based Biosensor for Kidney Disease Biomarker Uromodulin." Sensors 23, no. 24 (2023): 9696. http://dx.doi.org/10.3390/s23249696.

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We demonstrate the development of a label-free, impedance-based biosensor by using a passivation layer of 50-nm tantalum pentoxide (Ta2O5) on interdigitated electrodes (IDE). This layer was fabricated by atomic layer deposition (ALD) and has a high dielectric constant (high-κ), which improves the capacitive property of the IDE. We validate the biosensor’s performance by measuring uromodulin, a urine biomarker for kidney tubular damage, from artificial urine samples. The passivation layer is functionalized with uromodulin antibodies for selective binding. The passivated IDE enables the non-fara

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Bai, Yongchang, and Shuang Li. "Oxidative Stress Sensing System for 8-OHdG Detection Based on Plasma Coupled Electrochemistry by Transparent ITO/AuNTAs/PtNPs Electrode." Biosensors 13, no. 6 (2023): 643. http://dx.doi.org/10.3390/bios13060643.

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8-Hydroxydeoxyguanosine (8-OHdG) is the most widely used oxidative stress biomarker of the free radical-induced oxidative damage product of DNA, which may allow a premature assessment of various diseases. This paper designs a label-free, portable biosensor device to directly detect 8-OHdG by plasma-coupled electrochemistry on a transparent and conductive indium tin oxide (ITO) electrode. We reported a flexible printed ITO electrode made from particle-free silver and carbon inks. After inkjet printing, the working electrode was sequentially assembled by gold nanotriangles (AuNTAs) and platinum

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Aliheidari, Nahal, Nojan Aliahmad, Mangilal Agarwal, and Hamid Dalir. "Electrospun Nanofibers for Label-Free Sensor Applications." Sensors 19, no. 16 (2019): 3587. http://dx.doi.org/10.3390/s19163587.

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Electrospinning is a simple, low-cost and versatile method for fabricating submicron and nano size fibers. Due to their large surface area, high aspect ratio and porous structure, electrospun nanofibers can be employed in wide range of applications. Biomedical, environmental, protective clothing and sensors are just few. The latter has attracted a great deal of attention, because for biosensor application, nanofibers have several advantages over traditional sensors, including a high surface-to-volume ratio and ease of functionalization. This review provides a short overview of several electros

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Feng, Hui, Sheng Bo Sang, Wen Dong Zhang, et al. "Fundamental Study of the Micro-Cantilever for more Sensitive Surface Stress-Based Biosensor." Key Engineering Materials 562-565 (July 2013): 334–38. http://dx.doi.org/10.4028/www.scientific.net/kem.562-565.334.

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Surface stress-based biosensors as a crucial part of micro-scale and label-free system, use free energy change, the underlying concept in any binding reaction, have been investigated extensively in recent years. In this paper, a new bi-micro-cantilever surface stress biosensor is proposed which can be used to detect cells. Some fundamental study has been done, especially for the micro-cantilever due to its crucial role in the whole system. To acquiring the optimal material for more sensitive sensor, four material, Si, SiN, AlN, PMMA(polymethylmethacrylate), were contrastively analyzed under th

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Sedlackova, Eliska, Zuzana Bytesnikova, Eliska Birgusova, et al. "Label-Free DNA Biosensor Using Modified Reduced Graphene Oxide Platform as a DNA Methylation Assay." Materials 13, no. 21 (2020): 4936. http://dx.doi.org/10.3390/ma13214936.

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This work reports the use of modified reduced graphene oxide (rGO) as a platform for a label-free DNA-based electrochemical biosensor as a possible diagnostic tool for a DNA methylation assay. The biosensor sensitivity was enhanced by variously modified rGO. The rGO decorated with three nanoparticles (NPs)—gold (AuNPs), silver (AgNPs), and copper (CuNPs)—was implemented to increase the electrode surface area. Subsequently, the thiolated DNA probe (single-stranded DNA, ssDNA−1) was hybridized with the target DNA sequence (ssDNA-2). After the hybridization, the double-stranded DNA (dsDNA) was me

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Chiorcea-Paquim, Ana-Maria, and Ana Maria Oliveira-Brett. "DNA Electrochemical Biosensors for In Situ Probing of Pharmaceutical Drug Oxidative DNA Damage." Sensors 21, no. 4 (2021): 1125. http://dx.doi.org/10.3390/s21041125.

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Deoxyribonucleic acid (DNA) electrochemical biosensors are devices that incorporate immobilized DNA as a molecular recognition element on the electrode surface, and enable probing in situ the oxidative DNA damage. A wide range of DNA electrochemical biosensor analytical and biotechnological applications in pharmacology are foreseen, due to their ability to determine in situ and in real-time the DNA interaction mechanisms with pharmaceutical drugs, as well as with their degradation products, redox reaction products, and metabolites, and due to their capacity to achieve quantitative electroanaly

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Chiang, Hao-Chun, Yanyan Wang, Qi Zhang, and Kalle Levon. "Optimization of the Electrodeposition of Gold Nanoparticles for the Application of Highly Sensitive, Label-Free Biosensor." Biosensors 9, no. 2 (2019): 50. http://dx.doi.org/10.3390/bios9020050.

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A highly sensitive electrochemical biosensor with a signal amplification platform of electrodeposited gold nanoparticle (AuNP) has been developed and characterized. The sizes of the synthesized AuNP were found to be critical for the performance of biosensor in which the sizes were dependent on HAuCl4 and acid concentrations; as well as on scan cycles and scan rates in the gold electro-reduction step. Systematic investigations of the adsorption of proteins with different sizes from aqueous electrolyte solution onto the electrodeposited AuNP surface were performed with a potentiometric method an

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Cunningham, Brian T., Peter Li, Stephen Schulz, et al. "Label-Free Assays on the BIND System." Journal of Biomolecular Screening 9, no. 6 (2004): 481–90. http://dx.doi.org/10.1177/1087057104267604.

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Screening of biochemical interactions becomes simpler, less expensive, and more accurate when labels, such as fluorescent dyes, radioactive markers, and colorimetric reactions, are not required to quantify detected material. SRU Biosystems has developed a biosensor technology that is manufactured on continuous sheets of plastic film and incorporated into standard microplates and microarray slides to enable label-free assays to be performed with high throughput, high sensitivity, and low cost per assay. The biosensor incorporates a narrow band guided-mode resonance reflectance filter, in which

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Angulo Barrios, Carlos. "An Analysis of a Compact Label-Free Guiding-Wave Biosensor Based on a Semiconductor-Clad Dielectric Strip Waveguide." Sensors 20, no. 12 (2020): 3368. http://dx.doi.org/10.3390/s20123368.

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In this paper, a compact, integrated, semiconductor-clad strip waveguide label-free biosensor is proposed and analyzed. The device is based on CMOS-compatible materials such as amorphous-Si and silicon oxynitride. The optical sensor performance has been modeled by a three-dimensional beam propagation method. The simulations indicate that a 20-μm-long device can exhibit a surface limit of detection of 3 ng/cm2 for avidin molecules in aqueous solution. The sensor performance compares well to those displayed by other photonic biosensors with much larger footprints. The fabrication tolerances have

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Kaewda, Chanaporn, and Saengrawee Sriwichai. "Label-Free Electrochemical Dopamine Biosensor Based on Electrospun Nanofibers of Polyaniline/Carbon Nanotube Composites." Biosensors 14, no. 7 (2024): 349. http://dx.doi.org/10.3390/bios14070349.

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The development of conducting polymer incorporated with carbon materials-based electrochemical biosensors has been intensively studied due to their excellent electrical, optical, thermal, physical and chemical properties. In this work, a label-free electrochemical dopamine (DA) biosensor based on polyaniline (PANI) and its aminated derivative, i.e., poly(3-aminobenzylamine) (PABA), composited with functionalized multi-walled carbon nanotubes (f-CNTs), was developed to utilize a conducting polymer as a transducing material. The electrospun nanofibers of the composites were fabricated on the sur

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Yuhana Ariffin, Eda, Lee Yook Heng, Ling Ling Tan, Nurul Huda Abd Karim, and Siti Aishah Hasbullah. "A Highly Sensitive Impedimetric DNA Biosensor Based on Hollow Silica Microspheres for Label-Free Determination of E. coli." Sensors 20, no. 5 (2020): 1279. http://dx.doi.org/10.3390/s20051279.

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A novel label-free electrochemical DNA biosensor was constructed for the determination of Escherichia coli bacteria in environmental water samples. The aminated DNA probe was immobilized onto hollow silica microspheres (HSMs) functionalized with 3-aminopropyltriethoxysilane and deposited onto a screen-printed electrode (SPE) carbon paste with supported gold nanoparticles (AuNPs). The biosensor was optimized for higher specificity and sensitivity. The label-free E. coli DNA biosensor exhibited a dynamic linear response range of 1 × 10−10 µM to 1 × 10−5 µM (R2 = 0.982), with a limit of detection

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Fardoost, Ali, Hassan Raji, and Mehdi Javanmard. "Optimization of Nanowell-Based Label-Free Impedance Biosensor Based on Different Nanowell Structures." Biosensors 14, no. 9 (2024): 426. http://dx.doi.org/10.3390/bios14090426.

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Nanowell-based impedance-based label-free biosensors have demonstrated significant advantages in sensitivity, simplicity, and accuracy for detecting cancer biomarkers and macromolecules compared to conventional impedance-based biosensors. Although nanowell arrays have previously been employed for biomarker detection, a notable limitation exists in the photolithography step of their fabrication process, leading to a reduced efficiency rate. Historically, the diameter of these nanowells has been 2 μm. To address this issue, we propose alternative geometries for nanowells that feature larger surf

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Cui, Lin, Meng Wang, Bing Sun, Shiyun Ai, Shaocong Wang, and Chun-yang Zhang. "Substrate-free and label-free electrocatalysis-assisted biosensor for sensitive detection of microRNA in lung cancer cells." Chemical Communications 55, no. 8 (2019): 1172–75. http://dx.doi.org/10.1039/c8cc09688k.

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Shoute, Lian C. T., Carmen L. Charlton, Jamil N. Kanji, Shawn Babiuk, Lorne Babiuk, and Jie Chen. "Faradaic Impedimetric Immunosensor for Label-Free Point-of-Care Detection of COVID-19 Antibodies Using Gold-Interdigitated Electrode Array." Biosensors 14, no. 1 (2023): 6. http://dx.doi.org/10.3390/bios14010006.

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Label-free electrochemical biosensors have many desirable characteristics in terms of miniaturization, scalability, digitization, and other attributes associated with point-of-care (POC) applications. In the era of COVID-19 and pandemic preparedness, further development of such biosensors will be immensely beneficial for rapid testing and disease management. Label-free electrochemical biosensors often employ [Fe(CN)6]−3/4 redox probes to detect low-concentration target analytes as they dramatically enhance sensitivity. However, such Faradaic-based sensors are reported to experience baseline si

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Zhou, Jiawan, Wenyang Wang, Peng Yu, Erhu Xiong, Xiaohua Zhang, and Jinhua Chen. "A simple label-free electrochemical aptasensor for dopamine detection." RSC Adv. 4, no. 94 (2014): 52250–55. http://dx.doi.org/10.1039/c4ra08090d.

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Sana, Amrita Kumar, Keita Honzawa, Yoshiteru Amemiya, and Shin Yokoyama. "Silicon photonic crystal resonators for label free biosensor." Japanese Journal of Applied Physics 55, no. 4S (2016): 04EM11. http://dx.doi.org/10.7567/jjap.55.04em11.

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Zhuo, Yue, and Brian Cunningham. "Label-Free Biosensor Imaging on Photonic Crystal Surfaces." Sensors 15, no. 9 (2015): 21613–35. http://dx.doi.org/10.3390/s150921613.

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Syahir, Amir. "Label-free photonics biosensor transducing nano-biological events." Journal of Biochemistry, Microbiology and Biotechnology 2, no. 1 (2014): 32–38. http://dx.doi.org/10.54987/jobimb.v2i1.126.

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Studying protein characteristics and their molecular interactions can provide an important route to investigate protein networks in living cell. It can also postulate the functions of newly discovered genes or proteins, thus, hold great value for understanding disease mechanisms9-11 and providing suitable diagnostics for the global-threatening diseases.12,13 To date, works have vastly being done in these areas (proteomics studies) in order to develop a simple noninvasive tests that can indicate disease risk at early stage.14One of the keys that plays important role in these research areas is n

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de Goede, Michiel, Lantian Chang, Jinfeng Mu, et al. "Al2O3:Yb3+ integrated microdisk laser label-free biosensor." Optics Letters 44, no. 24 (2019): 5937. http://dx.doi.org/10.1364/ol.44.005937.

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