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Journal articles on the topic 'Blood characteristics and cognitive function'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Waldstein, Shari R. "The Relation of Hypertension to Cognitive Function." Current Directions in Psychological Science 12, no. 1 (2003): 9–12. http://dx.doi.org/10.1111/1467-8721.01212.

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Hypertension is an established risk factor for stroke. However, prior to such a major clinical event, hypertension exerts a more subtle impact on the brain that is revealed by diminished cognitive function. Studies comparing the performance of people with high and normal blood pressure levels have shown that high blood pressure or hypertension is related to poorer performance on tests of attention, learning and memory, executive functions, visuospatial skills, psychomotor abilities, and perceptual skills. Hypertension is also predictive of cognitive decline. Variables that may alter (i.e., mod

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Turusheva, A. V., T. A. Bogdanova, E. V. Frolova, and D. L. Logunov. "Characteristics of an elderly patient with cognitive impairments in outpatient practice." Russian Medical Inquiry 5, no. 10 (2021): 618–22. http://dx.doi.org/10.32364/2587-6821-2021-5-10-618-622.

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Aim: to study the prevalence of cognitive impairments (CI) in patients over 65 y.o., determine concomitant diseases and factors affecting cognitive functions (CF). Patients and Methods: a single-stage cross-sectional study of a continuous sample of patients (over 65 y.o. who applied for outpatient care from 24.10.2019 to 15.12.2019) in St. Petersburg was conducted. The study methods included: Montreal Cognitive Assessment (MoCA), Geriatric Depression Scale (GDS), blood pressure (BP) test, the study of outpatient medical histories, assessment of pharmacological treatment, laboratory studies (cl

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Fithrie, Aida, Fasihah Irfani Fitri, and Muhammad Reza Putra. "Association of Vitamin D Level and Nerve Conduction Study Parameters with Cognitive Function in Diabetic Neuropathy Patients." Open Access Macedonian Journal of Medical Sciences 9, B (2021): 72–78. http://dx.doi.org/10.3889/oamjms.2021.5938.

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BACKGROUND: Type 2 diabetes mellitus (T2DM) and its major long-term complication, diabetic polyneuropathy (DPN), continue to be a major global health problem and are important contributors of significant disability worldwide. Vitamin D plays a significant role in their pathogenesis as well as in the development of dementia in non-diabetic patients. Nevertheless, the role of Vitamin D in the development of cognitive impairment in DPN patients has not yet been extensively studied. AIM: We aimed to investigate the association between Vitamin D level and cognitive function in DPN patients and to e

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Haghayegh, Shahab, Ramon C. Hermida, Michael H. Smolensky, et al. "Critical Review of the Methodological Shortcoming of Ambulatory Blood Pressure Monitoring and Cognitive Function Studies." Clocks & Sleep 7, no. 1 (2025): 11. https://doi.org/10.3390/clockssleep7010011.

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Growing evidence suggests that abnormal diurnal blood pressure rhythms may be associated with many adverse health outcomes, including increased risk of cognitive impairment and dementia. This study evaluates methodological aspects of research on bidirectional associations between ambulatory blood pressure monitoring (ABPM) patterns and cognitive function. By examining the 28 recent studies included in a recent systematic review on the association between ABPM patterns with cognitive function and risk of dementia, our review revealed several significant limitations in study design, sample chara

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Palupi, Khairizka Citra, Siti Irma Durotunisa, Rachmanida Nuzrina, Yulia Wahyuni, and Harna Harna. "Glucose levels, diabetes duration, vitamin intake and their association with cognitive function in patients with type 2 diabetes mellitus." AcTion: Aceh Nutrition Journal 10, no. 2 (2025): 245. https://doi.org/10.30867/action.v10i2.2172.

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Type 2 Diabetes Mellitus may also contribute to cognitive decline. Risk factors for cognitive decline in patients with type 2 DM include demographic characteristics, clinical conditions, and nutritional intake. However, there is controversy regarding whether micronutrient intake affects cognitive function among type 2 DM. Thus, we aimed to investigate the determinants of cognitive function in patients with type 2 diabetes mellitus. A cross-sectional design was used in this study. This research was conducted in Marzoeki Mahdi Hospital, Bogor, West Java, from May to June 2023 among 98 respondent

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Bogdanova, Tatiana Andreevna, Anna V. Turusheva, Elena V. Frolova, and Dmitriy L. Logunov. "Elderly patients with cognitive impairments on an ambulance care." Russian Family Doctor 25, no. 2 (2021): 19–27. http://dx.doi.org/10.17816/rfd70198.

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BACKGROUND: Cognitive impairment is one of the most common geriatric syndromes that occur in the elderly. Dementia is a severe cognitive disorder that results in the professional, social, and functional impairment and gradual loss of independence. However, in most cases, the stage of dementia is preceded by a long period of non-dementia cognitive impairment. In this regard, one of the priorities of public health is to identify potentially reversible forms of dementia and cognitive impairment in the early stages. AIM: To assess demographic characteristics, co-morbidities and factors that

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Fokin, Vitaly F., Alla A. Shabalina, Natalia V. Ponomareva, Roman B. Medvedev, Olga V. Lagoda та Marine M. Tanashyan. "Аssociation of parameters of energy metabolism and levels of stress hormone cortisol with cognitive characteristics of patients with vascular encephalopathy". Annals of Clinical and Experimental Neurology 12, № 4 (2018): 47–51. https://doi.org/10.25692/acen.2018.4.6.

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Introduction. In patients with vascular encephalopathy (VE), the performance of cognitive tasks may be accompanied by stress and an increase in the level of cortisol affecting the regulation of insulin and glucose metabolism. It is known that an elevated level of cortisol may cause neurodegenerative changes in the hippocampus, and it also can lead to insulin resistance and hyperglycemia, which negatively affects cognitive function. Objective: to evaluate the association of parameters of cortisol, insulin and glucose levels and their reactivity with the cognitive results in patients with VE. Me

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Herceg, Jakov, Gorana Vukorepa, and Sandra Karanović Štambuk. "Primary Aldosteronism and Cognitive Dysfunction: A Case-Control Study." Journal of Clinical Medicine 14, no. 13 (2025): 4618. https://doi.org/10.3390/jcm14134618.

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Background: Primary aldosteronism is characterized by elevated aldosterone levels, leading to adverse effects such as hypertension, hypokalaemia and increased risk for cardiovascular and cerebrovascular events. Aldosterone impacts the central nervous system by promoting vascular remodelling and oxidative stress, potentially impairing cognitive function. The presence of mineralocorticoid receptors in the hippocampus, a key region for cognition, further suggest a link between primary aldosteronism and cognitive dysfunction. This study aims to further explore the association between hyperaldoster

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Gillespie, Kerri M., Melanie J. White, Eva Kemps, Halim Moore, Alexander Dymond, and Selena E. Bartlett. "The Impact of Free and Added Sugars on Cognitive Function: A Systematic Review and Meta-Analysis." Nutrients 16, no. 1 (2023): 75. http://dx.doi.org/10.3390/nu16010075.

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A relationship between excessive sugar consumption and cognitive function has been described in animal models, but the specific effects of sugars in humans remains unclear. This systematic review and meta-analysis aimed to evaluate the current knowledge, research characteristics, and quality of evidence of studies investigating the impacts of free and added sugars on human cognition in healthy participants. The review identified 77 studies (65 experimental trials, n = 3831; 9 cross-sectional studies, n = 11,456; and 3 cohort studies, n = 2059). All cohort studies and eight of the nine cross-se

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Yu, Jia, Aria Wei, Xiang-Zuo Pan, et al. "Silent Cerebral Infarction on Brain MRI Is Associated with Cognitive Impairment in Ittp Survivors in Hematological Remission." Blood 138, Supplement 1 (2021): 774. http://dx.doi.org/10.1182/blood-2021-151304.

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Abstract BACKGROUND: Individuals with immune mediated thrombotic thrombocytopenic purpura (iTTP) frequently exhibit cognitive impairment and are at higher risk of stroke than matched controls. However, the etiology of cognitive impairment in these individuals has not been established. We conducted this prospective study to examine the patterns of cognitive impairment and to test the hypothesis that cognitive impairment in iTTP survivors is associated with silent cerebral infarction (SCI, ischemic lesions on brain MRI without corresponding overt neurodeficits), which are also a risk factor for

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Samoilova, Yu G., M. V. Matveeva, D. V. Podchinenova, et al. "The relationship of free fatty acid levels with cognitive status and neuroimaging characteristics in adolescents with obesity." Obesity and metabolism 21, no. 2 (2024): 116–24. http://dx.doi.org/10.14341/omet13017.

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BACKGROUND: Obesity is a progressive health and economic problem of modern society. Endocrine-metabolic changes in childhood and adolescence have an impact on cognitive status, which is accompanied by changes in the perfusion of gray and white matter of the brain, as well as its architectonics.AIM: Verification of fatty acid (FA) levels in relation to cognitive function and brain neuroimaging data in adolescents with obesity.MATERIALS AND METHODS: The study is a single-center observational one-stage comparative. 60 teenagers aged 10–16 years were selected to participate. The main study group w

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Fokin, Vitaly F., Natalia V. Ponomareva, Roman B. Medvedev, Alla A. Shabalina, Marine M. Tanashyan, and Olga V. Lagoda. "Autonomic support of cognitive functions and functional asymmetry in normal aging and chronic cerebrovascular disorders." Annals of Clinical and Experimental Neurology 12, no. 5S (2018): 38–45. https://doi.org/10.25692/acen.2018.5.5.

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The increase in life expectancy is accompanied by an increase in the number of patients suffering from chronic cerebrovascular diseases with progressive cognitive decline, up to dementia. Therefore, the search for new approaches to studying the disease pathogenesis, prevention and treatment is relevant. We analysed the data on correlation of cognitive characteristics with reactions of the autonomic nervous system (ANS) and ANS-regulated systems in normal aging and in patients with vascular encephalopathy (VE). Reactivity of cerebral blood flow as a result of cortical-ANS interaction was studie

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Amad, Harun Nurdiansah, Anak Agung Ayu Putri Laksmidewi, and Ketut Widyastuti. "Characteristics of Vascular Cognitive Impairment in Acute Stroke Patients at Prof. Dr. I.G.N.G. Ngoerah General Hospital, September-October 2023." International Journal of Research and Review 11, no. 8 (2024): 384–91. http://dx.doi.org/10.52403/ijrr.20240841.

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Background: Vascular cognitive impairment (VCI) is a medical term that encompasses a spectrum of cognitive impairments resulting from cerebral vascular disease. This includes a range of conditions, from mild cognitive impairment to dementia, which is caused by damage to the brain's blood vessels. Objective: There have been few studies that provide a comprehensive understanding of vascular cognitive impairment, particularly in acute stroke patients. This study was therefore conducted to describe the characteristics of gender, age, type of stroke, and cognitive function in patients with acute st

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Freire, Carmen, Rosa Ramos, Esperanza Amaya, et al. "Newborn TSH concentration and its association with cognitive development in healthy boys." European Journal of Endocrinology 163, no. 6 (2010): 901–9. http://dx.doi.org/10.1530/eje-10-0495.

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ObjectiveAn association between thyroid function during pregnancy or infancy and neurodevelopment in children has been demonstrated. We aimed to investigate whether newborn TSH concentrations are related to subsequent neurocognitive development.DesignWe conducted a longitudinal study on 178 children from a general population birth cohort in Granada (Spain) born in 2000–2002.MethodsTSH concentrations were measured in umbilical cord blood, and cognitive functions were assessed at 4 years of age using the McCarthy's scales of children's abilities (MSCA). Organochlorine (OC) compound concentration

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Nowosad, Karolina. "Characteristics of the healthiest diets in the world." Journal of Life and Medical Sciences 1 (27) 2020 (January 31, 2020): 22–32. https://doi.org/10.5281/zenodo.5090870.

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The use of Mediterranean, DASH and flexitarian diets reduces blood pressure, weight loss and has a positive effect on blood glucose, insulin and cholesterol. The purpose of this review was to analyze experimental studies on the healthiest diets in the world and disease prevention. The results were analyzed for the effects of diets on hypertension, cardiovascular diseases, diabetes, obesity, cancer and neurodegenerative diseases. The Mediterranean diet showed a positive effect on the prevention of cardiovascular disease by reducing blood pressure, LDL and triglyceride levels and increasing HDL

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Kong, Qianqian, Xinxin Xie, Ziyue Wang, et al. "Correlations of Plasma Biomarkers and Imaging Characteristics of Cerebral Small Vessel Disease." Brain Sciences 14, no. 3 (2024): 269. http://dx.doi.org/10.3390/brainsci14030269.

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Cerebral small vessel disease (CSVD), which is a group of pathological processes affecting cerebral microvessels, leads to functional loss in the elderly population and mostly presents as cognitive impairment and gait decline. CSVD is diagnosed based on brain imaging biomarkers, but blood biomarkers are of great significance for the early diagnosis and progression prediction of CSVD and have become a research focus because of their noninvasiveness and easy accessibility. Notably, many blood biomarkers have been reported to be associated with CSVD in a relatively large population, particularly

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Siew Wei, Jeremy Ling, Liew Seng Yung, Ong Sheng Yang, et al. "Effects of Hypertension on Cognitive Functions among Rungus Population in Sabah." Borneo Journal of Medical Sciences (BJMS) 13, no. 1 (2019): 45. http://dx.doi.org/10.51200/bjms.v13i1.1095.

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Hypertension is the global disease burden and not only a major risk factor for stroke, but is also crucial risk factor for cognitive impairment and subsequently dementia. However, literature highlighting on cognitive functions is scarce in Malaysia. This study aimed to assess the hypertension and cognitive functions among the Rungus population in rural areas of Kudat, Sabah. A community based cross-sectional study was conducted among population aged 18 and above living in two villages of Kudat. A validated Malay version of Mini-Mental State Examination (M-MMSE) was used to assess cognitive fun

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Dobrynina, Larisa A., Bulat M. Akhmetzyanov, Zukhra Sh Gadzhieva, Еlena I. Kremneva, Lyudmila A. Kalashnikova, and Marina V. Krotenkova. "The role of arterial and venous blood flow and cerebrospinal fluid flow disturbances in the development of cognitive impairments in cerebral microangiopathy." Annals of Clinical and Experimental Neurology 13, no. 2 (2019): 19–31. https://doi.org/10.25692/acen.2019.2.3.

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Cerebral microangiopathy (CMA) is the main cause of vascular cognitive disorders, the leading cause of mixed dementia, and the main modifiable risk factor in Alzheimers disease. Study objective. To investigate the role of arterial and venous blood flow and cerebrospinal fluid flow, as well as their interrelation in the development of cognitive disorders in patients with CMA. Materials and methods. Ninety-six patients (32 men and 64 women, mean age 60.66.3 years) with cognitive complaints and CMA, diagnosed according to the STRIVE international MRI criteria, were examined. The severity of cogni

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Ran, Fang, Feng Liu, Ying Zhang, and Linyun Chen. "Serum Uric Acid and High-Sensitivity C-Reactive Protein as Predictors of Cognitive Impairment in Patients with Cerebral Infarction." Dementia and Geriatric Cognitive Disorders 49, no. 3 (2020): 235–42. http://dx.doi.org/10.1159/000507806.

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<b><i>Background:</i></b> Cognitive impairment induced by cerebral infarction has become a devastating health problem. More efficient predictors are required to evaluate the potential cognitive decline after cerebral infarction in clinic. Serum uric acid (UA) and high-sensitivity C-reactive protein (hs-CRP) are two factors reported to correlate with cognitive impairment. However, the understanding on serum UA and hs-CRP with cognitive dysfunction remains unclear. <b><i>Methods:</i></b> Serum UA and hs-CRP were evaluated in patients with cerebral

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Lee, Jinhyun, and Richard K. Shields. "Extracellular to Intracellular Body Water and Cognitive Function among Healthy Older and Younger Adults." Journal of Functional Morphology and Kinesiology 7, no. 1 (2022): 18. http://dx.doi.org/10.3390/jfmk7010018.

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Compromised cognitive function is associated with increased mortality and increased healthcare costs. Physical characteristics including height, weight, body mass index, sex, and fat mass are often associated with cognitive function. Extracellular to intracellular body water ratio offers an additional anthropometric measurement that has received recent attention because of its association with systemic inflammation, hypertension, and blood–brain barrier permeability. The purposes of this study were to determine whether extracellular to intracellular body water ratios are different between youn

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Huang, Andrew Jonathan, David Kornguth, and Steven Kornguth. "Cognitive Decline Secondary to Therapeutic Brain Radiation—Similarities and Differences to Traumatic Brain Injury." Brain Sciences 9, no. 5 (2019): 97. http://dx.doi.org/10.3390/brainsci9050097.

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Traumatic brain injury (TBI) resulting from forceful impacts on the torso and head has been of major interest because of the prevalence of such injuries in military personnel, contact sports and the elderly. Cognitive and behavioral changes associated with TBI are also seen following whole brain radiation treatment for cancer and chemotherapy for disseminated tumors. The biological mechanisms involved in the initiation of TBI from impact, radiation, and chemotherapy to loss of cognitive function have several shared characteristics including increases in blood brain barrier permeability, blood

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Shishkova, V. N. "The meaning of hypertensive therapy choice in the correction of cerebral affection: from mild cognitive impairment to dementia." Systemic Hypertension 12, no. 1 (2015): 58–64. http://dx.doi.org/10.26442/sg29096.

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Disorders and neuropathy are the leading cause of disability. Their partof total morbidity and disability is increasing due to the global growth of vascular diseases of the brain: the acute and the chronic disorders of cerebral circulation. The clinical characteristics of chronic disorders of cerebral circulation have been forming gradually, and include the development of cognitive impairments, up to dementia. The base for their development can serve thelong-term cardiovascular diseases (CVD). The problem of cognitive impairments in patients with CVD, particularly with arterial hypertension (A

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Li, Mengqi. "Progress on the study of fibroblast growth factors as novel therapeutics in post-stroke cognitive impairment." Aging Pathobiology and Therapeutics 3, no. 3 (2021): 48–55. http://dx.doi.org/10.31491/apt.2021.09.065.

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Post-stroke cognitive impairment (PSCI) is one of the most common complications after stroke, which severely affects the daily life abilities and social function of patients. Fibroblast growth factor (FGF), as a regulator of homeostasis, participates in the regulation of cell metabolism and hormone secretion, and can increase cerebral blood flow and promote nerve repair which improves PSCI. Here, we will conduct a review on the typing, characteristics, and mechanism of action of FGF to further understand its function and mechanism in PSCI

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Basaria, Shehzad, Ravi Jasuja, Grace Huang, et al. "Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss." Journal of Clinical Endocrinology & Metabolism 101, no. 12 (2016): 4669–80. http://dx.doi.org/10.1210/jc.2016-2726.

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Context: Some men who use finasteride for hair loss report persistent sexual and other symptoms after discontinuing finasteride therapy. Objective: To determine whether these persistent symptoms after discontinuation of finasteride use are due to androgen deficiency, decreased peripheral androgen action, or persistent inhibition of steroid 5α-reductase (SRD5A) enzymes. Participants: Finasteride users, who reported persistent sexual symptoms after discontinuing finasteride (group 1); age-matched finasteride users who did not report sexual symptoms (group 2); and healthy men who had never used f

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Mullane, Erin, Taylor Jones, Jenna Voutsinas, et al. "Patient-Reported Outcomes at Time of CAR-T Cell Therapy." Blood 136, Supplement 1 (2020): 35–36. http://dx.doi.org/10.1182/blood-2020-134646.

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Chimeric antigen receptor (CAR)-T cell therapy is a novel treatment with promising results for patients with hematological malignancies. Currently three FDA approved products are available for treatment of relapsed/refractory lymphoid malignancies, and several products are in different stages of clinical investigations for treatment of multiple myeloma and other hematological malignancies. CAR-T cell therapy has known early toxicities of cytokine release syndrome (CRS) and neurotoxicity, but little is known about long-term neuropsychiatric adverse effects. We previously reported neuropsychiatr

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Cimino, Nicolas, Min Suk Kang, Lawrence S. Honig, and Bret R. Rutherford. "Blood-Based Biomarkers for Alzheimer’s Disease in Older Adults with Posttraumatic Stress Disorder." Journal of Alzheimer's Disease Reports 6, no. 1 (2022): 49–56. http://dx.doi.org/10.3233/adr-210048.

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Background: Posttraumatic stress disorder (PTSD) is associated with cognitive decline and risk for dementia, but the neuropathology involved is unclear. Objective: The aim of this study was to determine whether PTSD is associated with increased levels of Alzheimer’s disease (AD) blood-based biomarkers. Methods: Individuals aged 50 years and older with PTSD were compared to trauma-exposed healthy controls (TEHCs) at baseline on serum measures of amyloid-β (Aβ) 42 and 40 levels, the Aβ42/Aβ40 ratio, and total tau. Serum was analyzed using ultrasensitive Simoa Human Neurology 3-Plex A assay (N3PA

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Lance, Eboni I., Aliyah Allick, Alicia Cannon, et al. "Feasibility of Validating a Screening Tool for Neurocognitive Function in Adults with SCD." Blood 144, Supplement 1 (2024): 3882. https://doi.org/10.1182/blood-2024-204141.

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Introduction: Sickle cell disease (SCD) is an inherited hematological disorder with high rates of neurological complications, including ischemic stroke and silent cerebral infarction. Even without brain injury, individuals with SCD may experience progressive neurocognitive impairment. Executive dysfunction and processing speed deficits are particularly common in patients with SCD, negatively impacting medical adherence, educational and occupational outcomes, and the transition from pediatric to adult care. The latest guidelines recommend neurocognitive surveillance and screening in adult patie

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Oishi, Ayame, and Takao Yamasaki. "Benefits of Badminton for Preventing Cognitive Decline and Dementia." Encyclopedia 4, no. 2 (2024): 984–96. http://dx.doi.org/10.3390/encyclopedia4020063.

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Badminton is one of the most popular racket sports played by all age groups worldwide. Anyone can practice and play badminton as a leisure or competitive sport, regardless of age, experience, or skill level. It does not require physical contact among players or expensive equipment. Compared with closed-skill exercises (e.g., running and swimming), open-skill exercises (e.g., badminton and table tennis) have been reported to significantly improve cognitive function and prevent cognitive decline. This mini review aimed to investigate the findings related to badminton intervention for cognitive f

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Hoshide, Satoshi, Masafumi Nishizawa, Hiroshi Kanegae, and Kazuomi Kario. "NUMBER OF HOME BLOOD PRESSURE MEASUREMENT AND COGNITIVE IMPAIRMENT." Journal of Hypertension 42, Suppl 1 (2024): e81. http://dx.doi.org/10.1097/01.hjh.0001020068.05115.ff.

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Objective: The advantage of home blood pressure (BP) measurement compared to office BP measurement can only be achieved if the patients remember to take the measurements as instructed. Cognitive function tends to decline with age, and individuals with mild cognitive impairment (MCI) often have difficulty completing established self-management tasks. Design and method: The aim of this study was to investigate the association between the number of days within a 5-and-a-half-day period that patients took their home BP as instructed and MCI assessed by the Japanese version of the Montreal Cognitiv

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Cortés-Álvarez, Nadia Yanet, Alfredo Lara-Morales, Elizabeth Bautista-Rodríguez, et al. "Job burnout, cognitive functioning, and Brain-derived neurotrophic factor expression among hospital Mexican nurses." PLOS ONE 19, no. 5 (2024): e0304092. http://dx.doi.org/10.1371/journal.pone.0304092.

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Aim To analyze the relationship between burnout syndrome, cognitive functions, and sBDNF (Serum Brain-derived Neurotrophic Factor) in Mexican nurses. Method A descriptive cross-sectional design was used. This study target staff nurses working in hospitals in Guanajuato, México. Demographic and working condition data were collected via questionnaire. The Maslach Burnout Inventory (MBI) was used to evaluate burnout. A blood sample were collected and processed by ELISA technique to measure sBDNF. Finally, the General Cognitive Assessment (CAB) of the Cognifit© neuropsychological battery was used

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Sharafeldin, Noha, Joshua Richman, Alysia Bosworth, et al. "Candidate SNPs enhance prediction of cognitive impairment after blood or marrow transplantation (BMT) for hematologic malignancy (HM)." Journal of Clinical Oncology 37, no. 15_suppl (2019): 11520. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.11520.

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11520 Background: We tested the hypothesis that candidate genetic variants are associated with cognitive impairment in BMT recipients for HM, and that inclusion of genetic variants improves the performance of a risk prediction model that includes only clinical and demographic characteristics. Methods: We used standardized tests to assess cognitive function in 277 adult BMT recipients at City of Hope (COH). Global Deficit Score (GDS) ≥0.50 was used as indicator of cognitive impairment. Generalized estimating equation models and logic regression were used to identify single-SNP and gene-level as

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Yomogida, Yukihito, Junko Matsuo, Ikki Ishida, et al. "An fMRI Investigation into the Effects of Ketogenic Medium-Chain Triglycerides on Cognitive Function in Elderly Adults: A Pilot Study." Nutrients 13, no. 7 (2021): 2134. http://dx.doi.org/10.3390/nu13072134.

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Evidence suggests that oral intake of medium-chain triglycerides (MCTs), which promote the production of ketone bodies, may improve cognitive functions in elderly people; however, the underlying brain mechanisms remain elusive. We tested the hypothesis that cognitive improvement accompanies physiological changes in the brain and reflects the use of ketone bodies as an extra energy source. To this end, by using functional magnetic resonance imaging, cerebral blood oxygenation level-dependent (BOLD) signals were measured while 20 healthy elderly subjects (14 females and 6 males; mean age: 65.7 ±

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Candrasmurti, Cloresta Shafa, Nurhidayati Nurhidayati, and Arina Windri Rivarti. "Perbedaan Kejadian Penurunan Fungsi Kognitif pada Individu Normotensi dan Hipertensi dari Populasi Pesisir di Kecamatan Pemenang Kabupaten Lombok Utara." Unram Medical Journal 12, no. 2 (2023): 166–70. http://dx.doi.org/10.29303/jk.v12i2.4392.

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Hypertension occurs due to vasoconstriction and impaired vasodilation which causes increased vascular resistance. Hypertension is the risk factor of Cognitive impairment decreased cognitive function through the mechanism of vascular damage and toxicity. Cognitive function is a complex function in the human brain including aspects of memory, language, attention, visuospatial, and orientation. Cognitive impairment is also influenced by age, gender, physical activity, health factors, and education. The purpose of this study was to measure the effect of blood pressure on cognitive impairment in co

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Yamasaki, Takao. "Benefits of Judo Training for Brain Functions Related to Physical and Cognitive Performance in Older Adults." Encyclopedia 3, no. 3 (2023): 981–95. http://dx.doi.org/10.3390/encyclopedia3030071.

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Judo is a well-known Japanese martial art that also features in Olympic games. Recently, an increasing interest has been observed in the application of judo as a multicomponent exercise, with a growing body of evidence showing that this feature improves physical and cognitive performance in older adults. Therefore, this review highlights the benefits of judo training in preventing physical and cognitive decline in older adults. Specifically, first, this review outlines the basic characteristics of judo (philosophy, match, and training). Subsequently, prior research examining the impacts of jud

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Bar, Merav, Julia Ruark, Erin Mullane, et al. "Patient-Reported Neuropsychiatric Outcomes of Long-Term Survivors after Chimeric Antigen Receptor (CAR)-T Cell Therapy." Blood 134, Supplement_1 (2019): 4453. http://dx.doi.org/10.1182/blood-2019-122755.

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CD19-targeted chimeric antigen receptor (CAR)-T cell therapy is a novel treatment with promising results for patients with relapsed/refractory lymphoid malignancies. CAR-T cell therapy has known early toxicities of cytokine release syndrome (CRS) and neurotoxicity, but little is known about long-term neuropsychiatric adverse effects. We have utilized patient-reported outcomes (PROs), including PROMIS®measures, to assess outcomes of patients with relapse/refractory chronic lymphocytic leukemia (CLL), non-Hodgkin lymphoma (NHL), and acute lymphoblastic leukemia (ALL) who were treated with CD19-t

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Uchiyama, Ichiro. "Differentiation of Fear, Anger, and Joy." Perceptual and Motor Skills 74, no. 2 (1992): 663–67. http://dx.doi.org/10.2466/pms.1992.74.2.663.

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The purpose of the present study was to identify the physiological characteristics corresponding to three affects (fear, anger, and joy), which were elicited through real situations in a laboratory. The subjects were asked to rate their psychological responses using the Affect Rating Scales for each affective situation. Physiological indices (diastolic and systolic blood pressures, heart rate, respiration rate, and frequency of galvanic skin response) were measured. The subjects' affects can be characterized by two functions obtained through discriminant analysis. One discriminant function sep

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Samoilova, Yu G. Yu G., M. V. Matveeva, O. S. Tonkikh, et al. "Morphometric characteristics of the brain in patients with type 1 diabetes mellitus on diff erent modes of basic bolus insulin therapy." Clinical Medicine (Russian Journal) 98, no. 5 (2020): 363–67. http://dx.doi.org/10.30629/0023-2149-2020-98-5-363-367.

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Objective — to study the morphometric characteristics of the brain in patients with type 1 diabetes mellitus (DM) receiving insulin therapy in diff erent modes, taking into account the variability of glycemia. Material and methods. 120 patients with type 1 diabetes, living in Tomsk and the Tomsk Region, were examined. All patients were divided into 2 groups: group 1 — patients receiving insulin in the base-bolus regimen of multiple insulin injections (MII), group 2 — using pump insulin therapy by continuous subcutaneous infusion of insulin using a wearable dispenser (CSII). Patients took this

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Ellis, Kathryn A., Ashley I. Bush, David Darby, et al. "The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease." International Psychogeriatrics 21, no. 4 (2009): 672–87. http://dx.doi.org/10.1017/s1041610209009405.

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ABSTRACTBackground: The Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging aimed to recruit 1000 individuals aged over 60 to assist with prospective research into Alzheimer's disease (AD). This paper describes the recruitment of the cohort and gives information about the study methodology, baseline demography, diagnoses, medical comorbidities, medication use, and cognitive function of the participants.Methods: Volunteers underwent a screening interview, had comprehensive cognitive testing, gave 80 ml of blood, and completed health and lifestyle questionnaires. One quar

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Lee, Jung-Ju, Jong-Moo Park, Kyusik Kang, Ohyun Kwon, Woong-Woo Lee, and Byung-Kun Kim. "Three Cases of Aphasic Status Epilepticus: Clinical and Electrographic Characteristics." Clinical Medicine Insights: Case Reports 14 (January 2021): 117954762110092. http://dx.doi.org/10.1177/11795476211009241.

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Aphasic status epilepticus (ASE) is unusual and has clinical characteristics similar to those of other disorders. Herein, we report 3 cases of ASE. A left-handed man (patient 1) showed continuous aphasia after the administration of flumazenil. He had underlying alcoholic liver cirrhosis and traumatic brain lesions in the right hemisphere. Electroencephalography (EEG) revealed periodic epileptiform discharges in the right frontotemporal area, which were intervened by rhythmic activity with spatiotemporal evolutions. A right-handed woman (patient 2) showed recurrent aphasia. Blood tests revealed

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Sekar, Nandinii, Shane C. Lenhart, Paritosh Mondal, et al. "Heme-Mediated Tau Phosphorylation Is Critical for Neuroaxonal Damage and Cognitive Impairment in Sickle Cell Disease." Blood 144, Supplement 1 (2024): 624. https://doi.org/10.1182/blood-2024-211179.

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A large proportion of patients with sickle cell disease (SCD) suffer from deficits in learning and memory function, and magnetic resonance imaging (MRI) evidence of cerebrovascular disease and neuroaxonal damage. Chronic and acute intravascular hemolysis release toxic free heme from the hemolyzed red blood cells resulting in severe anemia, which is a risk factor for cerebrovascular disease and cognitive impairment in SCD. However, the mechanistic link between heme and cerebrovascular injury is poorly understood. Astrocytes, the modified glial cells, constitute the neurovascular coupling that m

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Maruvada, Sai Sindhuri, V. Sornavalli, Poonambalaganapathi, and A. Gowri Sankar. "Mini mental state examination (MMSE) as a predictor of cognitive recovery in acute stroke." Romanian Journal of Neurology 24, no. 1 (2025): 20–26. https://doi.org/10.37897/rjn.2025.1.5.

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Introduction. Acute cerebrovascular accident (CVA) is a leading cause of morbidity and mortality worldwide, often resulting in long-term disability and cognitive impairments. Acute ischemic stroke leads to a sudden loss of blood circulation to an area of the brain, causing neurological dysfunction. Cognitive deficits post-stroke significantly impact the patient’s quality of life and ability to perform daily activities. The mini mental state examination (MMSE) is a widely used tool to screen for cognitive impairments and monitor changes in cognitive function, assessing domains such as orientati

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Jenson, Tara E., Kelly M. Bakulski, Keith Dookeran, Ira Driscoll, and Amy E. Kalkbrenner. "108 Chronic cadmium exposure is associated with cognition among adults over age 60 in a representative US sample." Journal of Clinical and Translational Science 6, s1 (2022): 2–3. http://dx.doi.org/10.1017/cts.2022.28.

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OBJECTIVES/GOALS: To examine the relationship between chronic cadmium exposure and cognitive function in later life, we estimated the association of urinary cadmium concentration on composite cognitive score, an important marker of progression toward dementia, while accounting for diet and key co-pollutants tobacco use and lead exposure. METHODS/STUDY POPULATION: After excluding those missing cognitive data (141) or covariate data (190), we included 760 persons >/= 60 years of age from the National Health and Nutrition Examination Survey (NHANES), 2011-2014. Urinary cadmium reflects prolong

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Ammar, Achraf, Khaled Trabelsi, Patrick Müller, et al. "The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis." Journal of Clinical Medicine 9, no. 3 (2020): 835. http://dx.doi.org/10.3390/jcm9030835.

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Context: As the food industry is continually involved in the development of new attractive alternative therapeutic agents, the evaluation of the beneficial impact of (poly)phenols on cognitive and brain function during aging has gained increasing interest. Objective: This systematic review and meta-analysis aimed to evaluate the acute and chronic effects of (poly)phenol-rich diet supplementation on cognitive function and brain health in aging adults. Data Sources: PubMed and Web of Science databases were searched for relevant randomized placebo-controlled trials (RCTs) published from inception

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Reading, Christopher L., Clarence N. Ahlem, and Michael F. Murphy. "NM101 Phase III study of NE3107 in Alzheimer’s disease: rationale, design and therapeutic modulation of neuroinflammation and insulin resistance." Neurodegenerative Disease Management 11, no. 4 (2021): 289–98. http://dx.doi.org/10.2217/nmt-2021-0022.

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Recently, the roles of inflammation and insulin resistance in neurodegeneration have become better appreciated. NE3107, an oral small molecule, blood-brain permeable anti-inflammatory insulin sensitizer that binds extracellular signal-regulated kinase, has been shown to selectively inhibit inflammation-driven ERK- and NF-κB-stimulated inflammatory mediators, including TNF-α, without inhibiting their homeostatic functions. We describe the rationale and design of NM101, the first randomized, multicenter Phase III clinical study to examine the safety and efficacy of 30 week treatment with NE3107

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Lkhagvasuren, Battuvshin, Zhiping P. Pang, Tsolmon Jadamba, et al. "Obesity and its associations with autonomic and cognitive functions in the general population." PLOS One 20, no. 5 (2025): e0322802. https://doi.org/10.1371/journal.pone.0322802.

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Background Obesity poses a significant global health burden. This study aimed to investigate the prevalence of obesity in Mongolia and its associations with autonomic and cognitive functions while considering potential psychosocial risk factors. Methods This population-based, cross-sectional study included 382 participants who underwent physical examinations, completed health-related questionnaires, and participated in heart rate variability (HRV) testing for autonomic assessment and the mini-mental state examination for cognitive evaluation. Results Obesity prevalence was 28.1% (age-sex adjus

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Xu, Min, Xiao-ying He, and Pan Huang. "The Relationship between Serum Amyloid A Level and Cognitive Dysfunction in Patients with Vascular Dementia: Preliminary Findings." BioMed Research International 2021 (February 15, 2021): 1–6. http://dx.doi.org/10.1155/2021/6676144.

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Objective. This study was aimed at investigating the relationship between serum amyloid A (SAA) levels and cognitive dysfunction in patients with vascular dementia (VAD). Methods. Using cross-sectional research methods, 146 patients with VAD were selected as the VAD group and 70 normal people were selected as the NC group. Upon admission, the clinical and biochemical characteristics of the two groups of study subjects were collected, and the MMSE scale was used to assess cognitive function. A sandwich enzyme-linked immunosorbent assay was used to detect SAA levels. Results. There was no signif

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Matos-Rodríguez, Amalia, Sorelis Sargenton-Savon, Yunaisys Mosqueda-Lobaina, and Eduardo Enrique Chibas-Muñoz. "Characteristics of the Dementia Syndrome in Primary Health Care." Interdisciplinary Rehabilitation / Rehabilitacion Interdisciplinaria 3 (June 30, 2023): 45. http://dx.doi.org/10.56294/ri202345.

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Introduction: Dementia is one of the most important organic brain disorders. It manifests itself chronically and progressively, with alterations in cognitive functions such as memory, thinking, orientation, calculation, language and learning ability without initially causing consciousness disorders. Objective: To characterize patients diagnosed with dementia syndrome in the Geriatrics Clinic of the "Policlínico Asdrúbal López Vázquez" in Guantánamo from June 2019 to July 2021. Methods: An observational, descriptive, cross-sectional study was conducted in the "Policlínico Asdrúbal López Vázquez

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Mrozkowiak, Mirosław, and Magdalena Mrozkowiak. "Próba oceny skuteczności terapii BEMER w procesie odnowy biologicznej po wysiłku wytrzymałościowym i wybranych funkcjach poznawczych. Opis przypadku = An attempt to evaluate the effectiveness of BEMER therapy wellness process after endurance exercise and cognitive functions selected." Journal of Education, Health and Sport 5, no. 9 (2015): 11–62. https://doi.org/10.5281/zenodo.29904.

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<strong>Mrozkowiak Mirosław, Mrozkowiak Magdalena. Próba oceny skuteczności terapii BEMER w procesie odnowy biologicznej po wysiłku wytrzymałościowym i wybranych funkcjach poznawczych. Opis przypadku = An attempt to evaluate the effectiveness of BEMER therapy wellness process after endurance exercise and cognit</strong><strong>ive functions selected. Case study. </strong><strong>Journal of Education, Health and Sport. </strong><strong>2015;5(9):11-62. ISSN 2391-8306. DOI</strong> <strong>10.5281/zenodo.29904</strong> <strong>http://dx.doi.org/10.5281/zenodo.29904</strong> <strong>http:/

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Shaltout, Hossam A., Katelyn R. Garcia, Xiaoyan Leng, et al. "Autonomic Function and Cognitive Function in the U.S. POINTER Neurovascular Ancillary Study." Alzheimer's & Dementia 19, S15 (2023). http://dx.doi.org/10.1002/alz.077086.

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AbstractBackgroundAutonomic regulation plays a major role in maintaining stable blood supply to the brain. Impaired autonomic function, as evidenced by high blood pressure variability (BPV) and/or low heart rate variability (HRV), is common in older adults and is associated with reduced perfusion, which can ultimately lead to impaired cognitive function. The U.S. POINTER Neurovascular (POINTER‐NV) ancillary study is an ongoing study designed to evaluate autonomic function in participants from the U.S. POINTER trial. Here we describe the baseline characteristics of the POINTER‐NV participants,

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Liu, Xiangliang, Yuguang Li, Xinqiao Chen, et al. "Revisiting the mechanisms linking blood glucose to cognitive impairment: new evidence for the potential important role of klotho." Frontiers in Endocrinology 15 (March 5, 2024). http://dx.doi.org/10.3389/fendo.2024.1323407.

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BackgroundThe association between blood glucose and cognition is controversial. Klotho is an anti-aging protein with neural protective effects. This study aimed to use a population-based study to disentangle the relationship between blood glucose levels and cognitive function in older adults, and to explore the role of klotho in it.MethodsA total of 1445 eligible participants from National Health and Nutrition Examination Survey (NHANES) 2011-2014 were included in our study. Cognitive function was assessed by Digit Symbol Substitution Test (DSST) and categorized into four quartiles (Q1-Q4). Ge

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