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Dissertations / Theses on the topic 'Calcium Channel Blockers – pharmacokinetics'

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Published: 4 June 2021

Last updated: 9 February 2022

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1

Al, Tafif Abdullah. "PREDICTION OF HUMAN SYSTEMIC, BIOLOGICALLY RELEVANT PHARMACOKINETIC PROPERTIES BASED ON PHYSICOCHEMICAL PROPERTIES OF CALCIUM CHANNEL BLOCKERS." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2868.

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This research explored quantitative relationships (QSPKR) between different molecular descriptors and pertinent, systemic PK properties for 14 calcium channel blockers (CCB). Physicochemical properties (PC) such as molecular weight (MW), molar volume (MV), calculated logP (clogP), pKa, calculated logD7.4 (clogD), % ionized at pH 6.3 and pH 7.4, hydrogen bond donors (HBD), hydrogen bond acceptors (HBA), and number of rotatable bonds (nRot) were chosen as possible predictor variables for systemic PK properties for CCB, obtained from pertinent literature, assessing the PK of CCB after intravenous

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2

Waite, Robert Patrick. "The actions of calcium antagonists on systemic hemodynamics, blood flow distribution and venous tone of the rat." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26661.

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The purpose of my study was to determine and compare the effects of three calcium antagonists on systemic hemodynamics, ECG, blood flow distribution, tissue conductance and venous tone of the rat. The effects of a representative drug from Spedding's (1985) three subclasses of calcium antagonists on systemic hemodynamics, ECG, cardiac output and the distribution of blood flow were investigated by the microsphere technique in pentobarbital-anesthetized rats. The representative drugs were: I, nifedipine (12 and 35 µg/kg/min); II, verapamil (43 and 83 µg/kg/min) and III, flunarizine (174 and 27

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3

Rajab, M. "Investigating calcium channel blockers as antimalarials." Thesis, University of Salford, 2018. http://usir.salford.ac.uk/47791/.

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The rise in resistance to current antimalarial drugs has led researchers to consider drug repositioning as a quicker alternative for drug development and discovery. Preliminary drug repositioning screens carried out at the University of Salford identified calcium channel blockers (CCBs) as potential antimalarial agents. A growing body of evidence has demonstrated the importance of calcium within the <I>Plasmodium</I> life cycle. Studies have shown CCBs and calmodulin inhibitors to exhibit antimalarial activity. The research carried out in this project aims to evaluate the antimalarial efficacy

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4

Ting, Mo-sin Queenie. "The relationship between calcium channel blockers and endothelial inflammation /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38297085.

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5

Ting, Mo-sin Queenie, and 丁慕仙. "The relationship between calcium channel blockers and endothelial inflammation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011485.

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6

Schwarzwald, Colin C. "Atrial and AV-nodal physiology in horses electrophysiologic and echocardiographic characterization and pharmacologic effects of diltiazem /." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1158079213.

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7

McNally, P. G. "The influence of calcium channel blockers on cyclosporin A nephrotoxicity." Thesis, University of Leicester, 1990. http://hdl.handle.net/2381/34162.

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Intrarenal vasoconstriction is a characteristic feature of cyclosporin A nephrotoxicity. This thesis investigates the effect of nifedipine, a dihydropyridine calcium channel blocker and potent renal vasodilator, on various aspects of experimental and clinical cyclosporin A nephrotoxicity. In the surgically intact spontaneously hypertensive rat (two-kidney model), short-term administration of cyclosporin A (14 days) induced a marked reduction in glomerular filtration rate and effective renal plasma flow, and an increase in renal vascular resistance. These changes were both reversible on stoppin

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8

Myrillas, Theofilos T. "Cellular mechanisms underlying the pathogenesis of cyclosporin A-induced gingival overgrowth." Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284391.

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9

Peterson, Blaise. "Molecular determinants of dihydropyridine binding on L-type calcium channels /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/6269.

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10

Wide-Swensson, Dag. "Hypertension in pregnancy effects of calcium channel blockade /." Lund : Dept. of Obstetrics and Gynecology, University of Lund, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39783426.html.

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11

Victory, Jason G. G. "Ion channels and the myocardium : interactions between general anaesthetics and calcium channel blockers." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253420.

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12

Brown, Clint. "In vitro effects of three organic calcium channel blockers on the rat pineal gland." Thesis, Rhodes University, 1992. http://hdl.handle.net/10962/d1003223.

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The calcium signal has emerged as an imponant component of intracellular regulation. Pineal function was thought to be slowed by the prominent calcification seen with increasing age, but recently it has been shown that calcium plays a crucial role in the adrenergic regulation of the gland. Beta-adrenoceptor stimulation increases melatonin (aMT) synthesis by increasing the activity of cyclic 3 '-5' adenosine mono phosphate (cAMP). Cyclic-AMP regulates the production of the pineal hormone, melatonin, from serotonin via the rate-limiting enzyme N-acetyltransferase (NAT). Increased intracellular c

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13

Achike, Francis Ifejika. "The cardiovascular responses to calcium channel blockers in rats subjected to blood gas/pH changes." Thesis, [Hong Kong] : University of Hong Kong, 1990. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12937095.

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14

Lynch, Mark. "A possible role for abscisic acid analogues as calcium channel blockers in mammalian smooth muscle." Thesis, Lancaster University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306480.

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15

Cunha, Gilmara Holanda da. "Efeito farmacolÃgico das fraÃÃes hexÃnica, clorofÃrmica e metanÃlica do Ãleo essencial da Alpinia zerumbet na reatividade vascular in vitro e nos parÃmetros cardiovasculares in vivo." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8041.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>A Alpinia zerumbet Ã uma planta da famÃlia Zingiberaceae, denominada popularmente âcolÃniaâ no Nordeste do Brasil. Ã utilizada com fins medicinais no tratamento de hipertensÃo e tem sido estudada em relaÃÃo as suas propriedades farmacolÃgicas. Esta pesquisa teve por objetivo analisar o efeito farmacolÃgico das fraÃÃes hexÃnica (FHOEAz), clorofÃrmica (FCOEAz) e metanÃlica (FMOEAz) do Ãleo essencial da Alpinia zerumbet (OEAz) na reatividade vascular in vitro e nos parÃmetros cardiovasculares in vivo. O projeto de pesquisa foi aprovad

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16

Kiguti, Luiz Ricardo de Almeida [UNESP]. "Velhas drogas, novas terapêuticas: investigação da utilização de antagonistas de adrenoceptores α1 e de bloqueadores de canais de cálcio no retardo da ejaculação". Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/91625.

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Made available in DSpace on 2014-06-11T19:25:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-06-23Bitstream added on 2014-06-13T20:53:14Z : No. of bitstreams: 1 kiguti_lra_me_botib.pdf: 1147680 bytes, checksum: 2af4ebdd84a8cedf1deef8d15145e30a (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A ejaculação precoce é a disfunção sexual masculina com maiores taxas de incidência e prevalência. De etiologia complexa, as principais abordagens farmacológicas desta condição têm sido a utilização de anestésicos locais, inibidores seletivos da recaptura de serotonina

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17

Alomari, Abdul-Hakeem Hussein Electrical Engineering &amp Telecommunications Faculty of Engineering UNSW. "Spectral analysis of arterial blood prssure and stroke volume variability: the role of Calcium channel blockers and sensitizers." Publisher:University of New South Wales. Electrical Engineering & Telecommunications, 2008. http://handle.unsw.edu.au/1959.4/43923.

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In this thesis, we included results from two studies. The first one considered the effects of the blood volume changes, during blood donation, on the heart rate variability (HRV) measured, non-invasively, form electrocardiographic (ECG) and photoplethysmographic (PPG) signals. Our results showed that, during blood donation, there were no significant changes in the pulsatile area of PPG signal, while heart rate increased. No significant changes were noticed in HRV extracted from both signals. Error analysis between the HRV extracted from ECG and peak interval variability (PIV) suggested that th

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18

Kiguti, Luiz Ricardo de Almeida. "Velhas drogas, novas terapêuticas : investigação da utilização de antagonistas de adrenoceptores α1 e de bloqueadores de canais de cálcio no retardo da ejaculação /". Botucatu : [s.n.], 2010. http://hdl.handle.net/11449/91625.

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Orientador: André Sampaio Pupo<br>Banca: Wilma de Grava Kempinas<br>Banca: Edson Antunes<br>Resumo: A ejaculação precoce é a disfunção sexual masculina com maiores taxas de incidência e prevalência. De etiologia complexa, as principais abordagens farmacológicas desta condição têm sido a utilização de anestésicos locais, inibidores seletivos da recaptura de serotonina e mais recentemente, inibidores da fosfodiesterase tipo 5. O reflexo ejaculatório é um processo altamente organizado com a interação de áreas centrais encefálicas e espinhais, centros autonômicos simpáticos e parasimpáticos além d

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19

Wong, Michelle Mon Yee. "A systematic review of the blood pressure lowering efficacy of calcium channel blockers in the treatment of primary hypertension." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31609.

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Context - Calcium channel blockers (CCBs) are widely used drugs to lower elevated blood pressure and manage angina and arrhythmias. Although the goal of antihypertensive therapy is to lower the risk of cardiovascular disease-related morbidity and mortality, efficacy is most often gauged by blood pressure reduction. Objectives — This systematic review of the blood pressure lowering efficacy of CCBs aims to determine the dose-related changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, and withdrawals due to adverse events (WDAE) with CCB treatment compare

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20

Hermann, David [Verfasser], and Andreas [Akademischer Betreuer] Draguhn. "Effects of Abeta Oligomers and State-Dependent Channel Blockers on High Voltage-Activated Calcium Channels / David Hermann ; Betreuer: Andreas Draguhn." Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://d-nb.info/1177148390/34.

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21

Lauener, Franz. "Comparative acute effects of the calcium channel blockers tiapamil, nisoldipine and nifedipine on blood pressure, heart rate, catecholamines, renin and aldosterone /." [S.l : s.n.], 1985. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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22

Deshpande, Laxmikant Sudhir. "Glutamate Excitotoxicty Activates a Novel Calcium Permeable Ion Channel in Cultured Hippocampal Neurons." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/688.

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Glutamate excitotoxicity is the predominant mechanism implicated in neuronal cell death associated with neurological disorders such as stroke, epilepsy, traumatic brain injury and ALS. Excessive stimulation of NMDA subtypes of glutamate receptors leads to protracted intracellular calcium elevations triggering calcium mediated neurotoxic mechanisms culminating in delayed neuronal cell death. In addition, glutamate excitotoxicity induces a NMDA dependent extended neuronal depolarization mediated by continuous calcium influx that correlates with delayed neuronal death. Attempts to prevent neurona

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23

Selvey, Christine Enid. "Comparative effects of calcium channel antagonism and beta-1 selective blockade on exercise performance in physically active hypertensive patients." Master's thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/26736.

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The current recommendations by the American Heart Association for health promotion are that all persons should partake in regular physical activity in order to reduce the risk of cardiovascular disease. Regular physical exercise reduces blood pressure and is an important component of the management of hypertension. It is therefore important that patients with hypertension participate in habitual physical exercise. Many hypertensive patients who exercise will require anti-hypertensive medication. However, some antihypertensive agents cause fatigue during exercise. In order for patients to gain

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24

Smit, Ruan. "Retrospective analysis of the prescribing patterns of calcium channel blockers in a section of the private health care sector of South Africa / Ruan Smit." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4934.

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Background: Calcium channel blockers are mainly divided into antihypertensive and antianginal treatment agents. In 2000 it was estimated that 972 million adults worldwide were living with hypertension and it is expected to affect 1.56 billion patients by 2025. The incremental expenditure for the antihypertensive therapeutic group in the United States of America was estimated at $US 55 billion per annum in 2006. It was stated that around seven million people in the United States of America suffered from angina, with around 400 000 new reports every year. Objective: To determine the prescribing

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25

Zhang, Yi. "Potential impact of breast cancer resistance protein on drug disposition during pregnancy /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/7970.

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26

Segawa, Daisuke. "Time dependency in the protection from myocardial injury after myocardial ischemia and reperfusion : new insights from experimental studies with the ultrashort-acting calcium antagonist clevidipine /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-141-1.

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27

Federico, Leonardo Bruno. "Planejamento e validação anti-proliferativa e anti-leishmania, de novos híbridos tri-funcionalizados unidos através do anel 1,2,3-triazol e compostos similares." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/59/59138/tde-03022017-141932/.

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As concepções de moduladores da dinâmica dos microtúbulos, que levam ao bloqueio do ciclo celular, e de bloqueadores de canais de cálcio tipo L (Cav), tais como o 1,4-di-hidropiridinas e análogos, que diminuem a resistência do organismo humano aos tratamentos quimioterápicos através da inibição da proteína de transmembrana P-gp, são estratégias importantes tanto para terapias antitumorais quanto para leishmanicida. Esta abordagem tem mostrado resultados interessantes na diminuição da resistência à quimioterapia em câncer chamada de MDR (do inglês Multi Drug Resistence), além de também serem u

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28

Spasevska, Ivana. "The role of EGR-1 and calcium influx in the antitumor activity of anti-CD20 monoclonal antibodies." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1304/document.

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Les anticorps monoclonaux (AcM) anti-CD20 sont essentiels pour le traitement du lymphome non hodgkinien et de la leucémie lymphoïde chronique (LLC). Les AcM agissent soit en activant directement la signalisation apoptotique dans les cellules cibles, soit via le système immunitaire. Dans une étude préclinique, nous avons montré que le traitement avec AcM anti-CD20, rituximab et GA101, induit l'expression de la protéine early growth response 1 (EGR-1) (Dalle et al., 2011). EGR-1 est un facteur de transcription régulé par le calcium (Ca2+) et CD20 est impliqué dans la régulation du flux calcique

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29

Vicentini, Fabio Carvalho. "Efeito da tansulosina e do nifedipino na eliminação de fragmentos após litotripsia extracorpórea por ondas de choque em pacientes com cálculos renais: estudo prospectivo, duplo-cego e randomizado." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-05052011-122956/.

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Introdução: A litotripsia extracorpórea por ondas de choque (LEOC) é o tratamento mais utilizado para cálculos renais de até 20 mm. O uso adjuvante de algumas drogas pode aumentar as taxas de sucesso do procedimento e diminuir a sua morbidade. Objetivos: Avaliar os efeitos da tansulosina e do nifedipino nas taxas de sucesso, nos episódios de dor e na velocidade de eliminação dos fragmentos após o tratamento de cálculos renais de 5 a 20 mm com uma única sessão de LEOC. Casuística e Métodos: Foram estudados prospectivamente 136 indivíduos portadores de cálculos renais entre 5 e 20 mm, submetidos

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30

Young, Lois-May. "Evaluation of polycyclic amines as modulators of calcium homeostasis in models of neurodegeneration / Young L." Thesis, North-West University, 2012. http://hdl.handle.net/10394/7591.

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Compromised calcium homeostasis in the central nervous system (CNS) is implicated as a major contributor in the pathology of neurodegeneration. Dysregulation of Ca2+ homeostasis initiates downstream Ca2+–dependent events that lead to apoptotic and/or necrotic cell death. Increases in the intracellular free calcium concentration ([Ca2+]i) may be the result of Ca2+ influx from the extracellular environment or Ca2+ release from intracellular Ca2+ stores such as the endoplasmic reticulum (ER). Influx from the extracellular environment is controlled predominantly by voltage gated calcium channels (

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31

Maynard, Luana Godinho. "Efeitos cardiovasculares do óleo essencial de Lippia alba (Mill) N.E. Brown. (Erva Cidreira Brasileira) em ratos." Universidade Federal de Sergipe, 2011. https://ri.ufs.br/handle/riufs/3845.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Lippia alba (Mill.) N.E. Brown (VERBENACEAE), popularly know as Erva Cidreira Brasileira, has been one of the most commonly herbs used in the Brazilian folk medicine to blood pressure control. This study aimed to investigate the cardiovascular effects of the essential oil of Lippia alba (EOLA) in rats. For the hemodynamic measurement, normotensive male Wistar rats had their abdominal aorta and lower vena cava cannulated. Initially, five chemotypes (geranial, limonene, linalool, mircene, and carvone) were tested in normotensive co

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Moraes, Rogerio Bonfante. "Efeitos do bloqueador de canais de cálcio amlodipina na reparação óssea em defeito cirúrgico no ramo mandibular de ratos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/23/23149/tde-24102009-114756/.

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Os anti-hipertensivos bloqueadores de canais de cálcio, por interferirem no transporte de cálcio através das membranas celulares, podem afetar muitos processos metabólicos, incluindo o metabolismo ósseo. O objetivo deste estudo foi avaliar, de forma radiográfica, histológica e bioquímica, os efeitos do bloqueador de canais de cálcio amlodipina no processo de reparo de um defeito ósseo, simulando fratura, no ramo mandibular de ratos. Foram utilizados 50 ratos machos Wistar, que foram submetidos ao mesmo procedimento cirúrgico unilateral simulando fratura mandibular, e distribuídos em dois grupo

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33

Gourine, Andrey. "The importance of nitric oxide bioavailability and endothelial mechanisms for cardioprotection by pharmacological intervention during myocardial ischaemia and reperfusion /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-069-9/.

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34

Lee, Mei-Jing, and 李玫靜. "Synthetic Studies on 1) Chiral Dihydropyridine Calcium Channel Blockers, and." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/14597829951321047479.

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博士<br>國立臺灣大學<br>藥學研究所<br>87<br>Abstract (I) 2,6-Disubstituted-4-aryl-1,4-dihydropyridine-3,5-dicarboxylic diesters are the most effective among clinically useful calcium channel blockers. Some second-generation dihydropyridines, such as nitrendipine, nivodipine, nimodipine , and amlodipine, are chiral due to unsymmetrical substitution, and demonstrate moderate to significant enantioselectivity in their pharmacological effects. The aim of this study is to apply literature methodolgies for the asymmetric nucleophilic addition at C-4 of pyridines to the synthesis of chiral d

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Lin, Xue-E., and 林雪娥. "Effects of organic calcium channel blockers on the neuromus cular transmission." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/51697770638621354022.

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McTavish, Alison J. "Calcium, calcium channel blockers, and aging in the rotifer Asplanchna brightwelli, gosse /Alison J. McTavish. --." Thesis, 1989. http://spectrum.library.concordia.ca/5828/1/ML49091.pdf.

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Mahmoud, Sherif. "Drug-disease interaction: effect of inflammation on the pharmacological response to calcium channel blockers." Phd thesis, 2010. http://hdl.handle.net/10048/1540.

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The present research is focused on the topic of inflammation-drug interaction. Inflammation complicates many human diseases and conditions ranging from obesity to cancer. Therefore, the study of the effect of inflammation on drug pharmacokinetics and pharmacodynamics is pivotal. First, we tested the hypothesis that controlling inflammation using valsartan can restore the previously reported altered verapamil pharmacokinetics and pharmacodynamics. Such an effect is expected due to the anti-inflammatory properties of angiotensin II inhibition. Inflammation resulted in L-type calcium channel targ

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Chen, Chun-Zhu, and 陳春珠. "Effects of intracerebrally administered calcium channel blockers in normal and cerebral ischemic rats." Thesis, 1986. http://ndltd.ncl.edu.tw/handle/33111726822959753482.

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"Exploring calcium channels using divalent cations and specific channel blockers in frog sympathetic neurons." Tulane University, 2001.

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In the present study, distinctive interactions of divalent cations and specific blockers with calcium channels were exploited to probe several functional features related to permeation through calcium channels in frog sympathetic neurons In the first study, our experiments have focused on resolving a paradox why the whole-cell current has not been observed under typical recording conditions for one type of calcium channel that is highly expressed in frog sympathetic neurons. These channels are referred to as Ef-channels, and they are present in the membrane at a density greater than the channe

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Yi-Tung and 張益通. "Meta-Analysis for Comparison of Calcium Channel Blockers in Nifedipine With Amlodipine (Evidence-Based Medicine)." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/06316604978798939523.

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碩士<br>中山醫學大學<br>醫學研究所<br>100<br>Background :According to statistics, the blood pressure lowering drugs is the best selling drug in Taiwan. Taiwan ranked top 20 selling drugs in lowering blood pressure drug accounted for five, the five major antihypertensive drug annual sales of more than 6.5 billion yuan, sales approaching three hundred million, people eat more than eighty per day ten thousand blood pressure lowering drugs. Because hypertension is caused by stroke and coronary heart disease is one important reason, the law is very important to take medicine to control blood pressure, coupled w

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Huang, An-Hsiang, and 黃安祥. "Electrophysiological and antiarrhythmic studies of new-type calcium channel blockers, labedipinedilols, on cardiac myocytes and tissues." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/91288360312702163441.

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碩士<br>高雄醫學大學<br>醫學研究所<br>91<br>Labedipinedilol-A, -B and -C are synthetic 1,4-dihydropyride derivatives with /-adrenoceptor and calcium channel blockading activities. As demonstrated previously, labedipinedilol-A, -B and -C have been described with triple blocking activities on /-adrenergic receptor and L-type calcium channel, functioning in a molecule displaying monotherapy properties on rats. However, a direct electrophysiological characterization of these drugs has not yet been documented at single cell level. The aim of present study is to elucidate the ionic mechanisms underlying the

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Wang, YI-CHUN, and 王奕淳. "Risks of Adverse Events Following Coprescritption of Statins and Calcium Channel Blockers – A Nationwide Population-Based Study." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/8hf8es.

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博士<br>慈濟大學<br>醫學科學研究所<br>104<br>Some statins (simvastatin, lovastatin, and atorvastatin) are metabolized by cytochrome P450s 3A4 (CYP3A4). Inhibitors of CYP3A4 including some calcium channel blockers (CCB) might increase statin blood concentration, owing to drug-drug interactions. Risk of adverse events such as acute kidney injury might occur following the coprescription of CYP3A4-metabolized statins and CCBs that inhibit CYP3A4. This was a population-based cohort study. The study analyzed data of patients treated between 1997 and 2011, retrieved from Taiwan’s National Health Insurance databas

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Chikhale, R., S. Thorat, A. Pant, et al. "Design, synthesis and pharmacological evaluation of pyrimidobenzothiazole-3-carboxylate derivatives as selective L-type calcium channel blockers." 2015. http://hdl.handle.net/10454/9327.

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No<br>L-type voltage gated calcium channels play essential role in contraction of various skeletal and vascular smooth muscles, thereby plays important role in regulating blood pressure. Dihydropyridine receptors have been targeted for development of newer antihypertensive agents, one of the structurally analogs nucleus dihydropyrimidines have been reported earlier by us as a potential agent toward development of calcium channel modulator. A pre-synthetic QSAR was run and on the basis of structure activity relationship a series of twenty three molecules was synthesized and studied by myosin li

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Hsieh, Pocheng, and 謝博丞. "Effects Of Calcium Channel Blockers On Mechanical Contractions Of Rabbits Pulmonary Veins Sleeves: An In-vitro Study." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/64408419164178410243.

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碩士<br>靜宜大學<br>財務與計算數學系<br>100<br>Pulmonary vein sleeves are composed of cardiac muscles cells and play certain roles in the arrhythmogenesis of certain atrial arrhythmias. In literatures, it has been demonstrated that there exist a high proportion of intrinsic pacemakers and triggered activities in pulmonary vein sleeves of dogs and rabbits. By contrast, other research groups discovered a contradictory finding: under normal condition, there are no intrinsic pacemakers in cardiac myocytes of pulmonary vein sleeves of dogs, rabbits and rabbits. The main purpose of the present study is to explore

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Chao, Su-Hui, and 趙素慧. "Photosensitivity drugs(I) Photodegradation of calcium channel blockers(II) Photoproducts of NSAIDs and their anti-inflammatory activities." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/89841605521014148399.

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博士<br>臺北醫學大學<br>藥學研究所<br>95<br>Photosensitivity is a commonly adverse effect of drugs. The purpose of the first part of this study is focus on the photodegradation of nicardipine. When nicardipine was exposed to the Hg lamp, eight photoproducts of nicardipine were identification by LC/MS. The main degraded product was a pyridine analogue (NIC-7). Nicardipine apparently undergoes a series of nitro group photo-reduction pathways under irradiation leading to a complex formation of mainly the reduced products. A reaction scheme of nicardipine was proposed. The second part, gives a study on the ph

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林立婷. "Studies on new interactive compounds between photosensitive 1,4-dihydropyridine calcium channel blockers and vitamin C : The changes in calcium ions blocking activity." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/ppszt4.

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碩士<br>國立中正大學<br>化學暨生物化學研究所<br>105<br>This study was based on the preparation of new interactive compounds between photosensitive 1,4-dihydropyridine drugs (i.e. nifedipine and nisoldipine) and vitamin C. These compounds are purified and identified as 6-Hydroxy-2,4-dimethyl-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridinen-1-carboxylic acid methyl ester (named as cpd.4 in this thesis) and 6-Hydroxy-2,4-dimethyl-5-oxo-5,6-dihydrobenzo[c][2,7] naphthyridinen-1-carboxylic acid isobutyl ester (named as cpd.8) using high-performance liquid chromatography (HPLC) and electrospray ionization mass spectromet

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Doong, Joe-Yuan Howard. "Alteration of fibroblast cell shape and induction of procollagenase synthesis by calcium channel blockers, calmodulin inhibitors and protein kinase C inhibitors /." 1996. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:9720032.

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Chen, Jy-Yih, and 陳之益. "Investigation on the synthesis of Dihydropyridine Calcium Channel Blockers via Nucleophilic Addition of Organometallics onto 2,3,5,6-Tetrasubstitued Pyridines." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/58397070595361149891.

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碩士<br>國立臺灣大學<br>藥學研究所<br>82<br>2,6-雙取代-4-芳香基-1,4-二氫仳啶-3,5-雙羧酸雙酯類化合物 (1)是當今最有效的鈣離子通道阻斷劑 (鈣離子拮抗劑)。合成這一類化合物最通用的方法為Hantzsch 反應，它是一種由乙醯乙酸酯，醛及氨氣等所進行的縮合反應。有機金屬與啶類衍生物之親核性反應，在文獻中已有相當廣泛的研究報導。但據我們所知，以有機金屬加成至啶類衍生物的方法，尚未被成功地應用於合成具有活性亦即具有 2,6-雙甲基取代的二氫啶類化合物.我們為了以親核性反應合成具 2,6-雙甲基取代的二氫仳啶類化合物，首先合成了 5-(4,4-雙甲基-4,5-二氫-2-愕唑基)-2,6-雙甲基-菸鹼酸乙酯 (6)。再以化合物6與苯基鋰反應。但並沒有如同2,6位置無取代之仳啶類化合物 10一樣得到二氫仳啶類似物11，卻產生 [(5-(4,4-雙甲基-4,5-二氫-2-愕唑基)-2,6-雙甲基-3-仳啶基]-苯基-甲

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Oudit, Gavin Y. "Role of L-type Ca2+ channel and oxidative stress in the pathogenesis of iron-overload cardiomyopathy : calcium channel blockers and taurine as potential therapies." 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=371012&T=F.

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Ko, Li-Chin, and 柯孋衿. "Effects of Angiotensin II Receptor Antagonists and Calcium Channel Blockers on Cardiovascular Neural Regulation in Hypertensive Patients During Daytime Nap Sleep." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/02598723125739492210.

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碩士<br>國立陽明大學<br>腦科學研究所<br>103<br>Background: Enhanced sympathetic drive has been established as being associated with the early stage of essential hypertension, suggesting the autonomic dysregulation may be key to the disease's etiology and progression. Sympathetic predominance in hypertension is associated with deleterious effects on target organs and predicts the development of cardiovascular complications. The effects of antihypertensive agents on cardiovascular autonomic function remain controversial. Methods: In total, 53 patients with essential hypertension and 39 healthy control subject

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