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Journal articles on the topic 'CANCER-ASSOCIATED MICROBE'

Author: Grafiati

Published: 11 September 2023

Last updated: 31 July 2025

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1

Gnanasekar, Aditi, Neil Shende, Jaideep Chakladar, et al. "Abstract 3528: Influence of obesity-associated intra-tumor microbes on exacerbating cancer severity." Cancer Research 82, no. 12_Supplement (2022): 3528. http://dx.doi.org/10.1158/1538-7445.am2022-3528.

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Abstract Background: Despite there being a well-established connection between the gut microbiome and metabolic disease in humans, intra-tumor microbes and the mechanisms by which they regulate cell signaling, inflammation, and adipocyte growth to exacerbate disease severity in cancer patients also suffering from obesity remains largely unclear. In this study, we identified microbes to be distinctly abundant in cancer patients who are obese and correlated microbe abundance to patient survival, clinical variables, and immunological genes and pathways, in order to mechanistically explain how dif

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Bose, Mukulika, and Pinku Mukherjee. "Microbe–MUC1 Crosstalk in Cancer-Associated Infections." Trends in Molecular Medicine 26, no. 3 (2020): 324–36. http://dx.doi.org/10.1016/j.molmed.2019.10.003.

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Li, Wei Tse, Anjali S. Iyangar, Rohan Reddy, et al. "The Bladder Microbiome Is Associated with Epithelial–Mesenchymal Transition in Muscle Invasive Urothelial Bladder Carcinoma." Cancers 13, no. 15 (2021): 3649. http://dx.doi.org/10.3390/cancers13153649.

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The intra-tumor microbiome has recently been linked to epithelial–mesenchymal transition (EMT) in a number of cancers. However, the relationship between EMT and microbes in bladder cancer has not been explored. In this study, we profiled the abundance of individual microbe species in the tumor samples of over 400 muscle invasive bladder carcinoma (MIBC) patients. We then correlated microbe abundance to the expression of EMT-associated genes and genes in the extracellular matrix (ECM), which are key players in EMT. We discovered that a variety of microbes, including E. coli, butyrate-producing

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Malik, Hafiza Iqra, and Muhammad Imran Qadir. "Relation between Gut Microbiota and Cancer." JOURNAL OF MICROBIOLOGY AND MOLECULAR GENETICS 2, no. 1 (2021): 45–54. http://dx.doi.org/10.52700/jmmg.v2i1.28.

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Human has about 100 trillion symbiotic microbes in the gut with 300-1000 different species. Gut microbiota is associated with host metabolism, obesity, diabetes, hepatic disorder, and cancer. Nowadays, studies are focusing on the role of gut microbiota in cancer. Evidence shows that Fusobacterium is associated with colorectal cancer when its genome was confirmed by 16SRNA analysis and PCR technique in cancerous cell. The complete mechanism of gut microbe involvement in cancer is still unknown. There may be some association of toxic metabolites of gut microbes, dietary substances, and the immun

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Sayed, Ibrahim M., Anirban Chakraborty, Amer Ali Abd El-Hafeez, et al. "The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells." Cells 9, no. 9 (2020): 1980. http://dx.doi.org/10.3390/cells9091980.

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Colorectal cancer (CRC) is the third most prevalent cancer, while the majority (80–85%) of CRCs are sporadic and are microsatellite stable (MSS), and approximately 15–20% of them display microsatellite instability (MSI). Infection and chronic inflammation are known to induce DNA damage in host tissues and can lead to oncogenic transformation of cells, but the role of DNA repair proteins in microbe-associated CRCs remains unknown. Using CRC-associated microbes such as Fusobacterium nucleatum (Fn) in a coculture with murine and human enteroid-derived monolayers (EDMs), here, we show that, among

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Ponath, Falk, Caroline Tawk, Yan Zhu, Lars Barquist, Franziska Faber, and Jörg Vogel. "RNA landscape of the emerging cancer-associated microbe Fusobacterium nucleatum." Nature Microbiology 6, no. 8 (2021): 1007–20. http://dx.doi.org/10.1038/s41564-021-00927-7.

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Uzelac, Matthew, Wei Tse Li, Jaideep Chakladar, Daniel John, and Weg M. Ongkeko. "Abstract LB110: Racial and ethnic disparities associated with the intratumor microbiome in female cancers." Cancer Research 83, no. 8_Supplement (2023): LB110. http://dx.doi.org/10.1158/1538-7445.am2023-lb110.

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Abstract Background: The intratumor microbiome is implicated in tumor initiation, progression, and altered immune response to cancer therapies. Furthermore, recent studies have revealed correlations between microbial abundance and racial disparities in cancer. While these investigations provide novel insights into cancer disparities research, few have investigated which racial and ethnic disparities exist for patients with female malignancies. In this study, we characterized the intratumor microbiome according to racial and ethnic disparities in common female malignancies including breast, cer

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Armstrong, Heather, Michael Bording-Jorgensen, Stephanie Dijk, and Eytan Wine. "The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It." Cancers 10, no. 3 (2018): 83. http://dx.doi.org/10.3390/cancers10030083.

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Cancer is a multifaceted condition, in which a senescent cell begins dividing in an irregular manner due to various factors such as DNA damage, growth factors and inflammation. Inflammation is not typically discussed as carcinogenic; however, a significant percentage of cancers arise from chronic microbial infections and damage brought on by chronic inflammation. A hallmark cancer-inducing microbe is Helicobacter pylori and its causation of peptic ulcers and potentially gastric cancer. This review discusses the recent developments in understanding microbes in health and disease and their poten

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Wang, Di, Yan Cui, Yuxuan Cao, Yuehan He, and Hui Chen. "Human Microbe-Disease Association Prediction by a Novel Double-Ended Random Walk with Restart." BioMed Research International 2020 (August 11, 2020): 1–8. http://dx.doi.org/10.1155/2020/3978702.

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Microorganisms in the human body play a vital role in metabolism, immune defense, nutrient absorption, cancer control, and prevention of pathogen colonization. More and more biological and clinical studies have shown that the imbalance of microbial communities is closely related to the occurrence and development of various complex human diseases. Finding potential microbial-disease associations is critical for understanding the pathology of a few diseases and thus further improving disease diagnosis and prognosis. In this study, we proposed a novel computational model to predict disease-associ

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Liu, Yunjie, Yao-zhong Zhang, and Seiya Imoto. "Microbial Gene Ontology informed deep neural network for microbe functionality discovery in human diseases." PLOS ONE 18, no. 8 (2023): e0290307. http://dx.doi.org/10.1371/journal.pone.0290307.

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The human microbiome plays a crucial role in human health and is associated with a number of human diseases. Determining microbiome functional roles in human diseases remains a biological challenge due to the high dimensionality of metagenome gene features. However, existing models were limited in providing biological interpretability, where the functional role of microbes in human diseases is unexplored. Here we propose to utilize a neural network-based model incorporating Gene Ontology (GO) relationship network to discover the microbe functionality in human diseases. We use four benchmark da

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Wei, Yu-Feng, Ming-Shyan Huang, Cheng-Hsieh Huang, Yao-Tsung Yeh, and Chih-Hsin Hung. "Impact of Gut Dysbiosis on the Risk of Non-Small-Cell Lung Cancer." International Journal of Environmental Research and Public Health 19, no. 23 (2022): 15991. http://dx.doi.org/10.3390/ijerph192315991.

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Background: The imbalance of gut microbiota, dysbiosis, is associated with various malignant diseases. This study aimed to identify the characteristics of gut microbiota in age-matched treatment-naïve non-small-cell lung cancer (NSCLC) patients and healthy individuals to investigate possible gut-microbe-related pathways involved in the development of NSCLC. Methods: We enrolled 34 age-matched NSCLC patients and 268 healthy individuals. Hypervariable V3–V4 amplicons of 16S rRNA in freshly collected fecal samples were sequenced. Diversity, microbial composition, functional pathways, smoking hist

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Chakladar, Jaideep, Daniel John, Shruti Magesh, et al. "The Intratumor Bacterial and Fungal Microbiome Is Characterized by HPV, Smoking, and Alcohol Consumption in Head and Neck Squamous Cell Carcinoma." International Journal of Molecular Sciences 23, no. 21 (2022): 13250. http://dx.doi.org/10.3390/ijms232113250.

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Head and neck squamous cell carcinoma (HNSCC) tumor phenotypes and clinical outcomes are significantly influenced by etiological agents, such as HPV infection, smoking, and alcohol consumption. Accordingly, the intratumor microbiome has been increasingly implicated in cancer progression and metastasis. However, few studies characterize the intratumor microbial landscape of HNSCC with respect to these etiological agents. In this study, we aimed to investigate the bacterial and fungal landscape of HNSCC in association with HPV infection, smoking, and alcohol consumption. RNA-sequencing data were

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Wang, Yen-Chieh, Wei-Chi Ku, Chih-Yi Liu, et al. "Supplementation of Probiotic Butyricicoccus pullicaecorum Mediates Anticancer Effect on Bladder Urothelial Cells by Regulating Butyrate-Responsive Molecular Signatures." Diagnostics 11, no. 12 (2021): 2270. http://dx.doi.org/10.3390/diagnostics11122270.

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In bladder cancer, urothelial carcinoma is the most common histologic subtype, accounting for more than 90% of cases. Pathogenic effects due to the dysbiosis of gut microbiota are localized not only in the colon, but also in regulating bladder cancer distally. Butyrate, a short-chain fatty acid produced by gut microbial metabolism, is mainly studied in colon diseases. Therefore, the resolution of the anti-cancer effects of butyrate-producing microbes on bladder urothelial cells and knowledge of the butyrate-responsive molecules must have clinical significance. Here, we demonstrate a correlatio

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Hoyd, Rebecca, Caroline E. Wheeler, Samuel Coleman, et al. "Abstract 5907: The tumor microbiome associates with features of the tumor microenvironment, treatment outcomes, and histologies: A national collaboration of the exORIEN Consortium." Cancer Research 83, no. 7_Supplement (2023): 5907. http://dx.doi.org/10.1158/1538-7445.am2023-5907.

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Abstract A tumor microbiome has recently been established as present in many cancer types. Further study is needed to define the scope of its role in cancer tumorigenesis, progression, and treatment outcomes. The Oncology Research Information Exchange Network (ORIEN) established a collaboration among eight member institutions to study the tumor microbiome and clinical features across several cancers. We evaluated RNAseq data from n = 2,892 tumors, including colorectal adenocarcinomas, lung adeno- and squamous cell carcinomas, pancreatic adenocarcinomas, sarcomas, melanomas, and thyroid carcino

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Zhang, Qinyuan, Wen Wu, Fanying Guo, et al. "Characteristics of Gut Microbiota and Fecal Metabolites in Patients with Colorectal Cancer-Associated Iron Deficiency Anemia." Microorganisms 12, no. 7 (2024): 1319. http://dx.doi.org/10.3390/microorganisms12071319.

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Patients with colorectal cancer (CRC) have a high prevalence of iron deficiency anemia (IDA), and the gut microbiota is closely related to iron metabolism. We performed metagenomic and metabolomic analyses of stool samples from 558 eligible samples, including IDA CRC patients (IDA, n = 69), non-anemia CRC patients (Non-Anemia, n = 245), and healthy controls (CTRL, n = 244), to explore the dynamically altered gut microbes and their metabolites. Compared with the CTRL group, fecal bacteria in both the IDA group and the Non-Anemia group showed a decrease in alpha diversity and changes in microbia

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Yang, Jihye, Hyumin Woo, Siyoung Yang, and Seong-il Eyun. "Abstract 5021: Multi-omics integration reveals interplay among intratumoral microbiome, host metabolism, and immune response in non-small cell lung cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 5021. https://doi.org/10.1158/1538-7445.am2025-5021.

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Abstract The lung, constantly exposed to diverse microorganisms, harbors a microbiome that can influence disease development, including cancer, through mechanisms such as altered immune function and host metabolism. While intratumoral microbiota have been linked to cancer progression and therapy response, their specific role in lung cancer remains poorly understood. Microbial metabolites play a crucial role in mediating the host signaling and metabolic pathways. However, the precise connection between intratumoral microbiota and cancer metabolism is still unresolved. To address this, we compre

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Kim, Boram, Eun Ju Cho, Jung-Hwan Yoon, et al. "Pathway-Based Integrative Analysis of Metabolome and Microbiome Data from Hepatocellular Carcinoma and Liver Cirrhosis Patients." Cancers 12, no. 9 (2020): 2705. http://dx.doi.org/10.3390/cancers12092705.

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Aberrations of the human microbiome are associated with diverse liver diseases, including hepatocellular carcinoma (HCC). Even if we can associate specific microbes with particular diseases, it is difficult to know mechanistically how the microbe contributes to the pathophysiology. Here, we sought to reveal the functional potential of the HCC-associated microbiome with the human metabolome which is known to play a role in connecting host phenotype to microbiome function. To utilize both microbiome and metabolomic data sets, we propose an innovative, pathway-based analysis, Hierarchical structu

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León-Letelier, Ricardo A., Rongzhang Dou, Jody Vykoukal, et al. "Contributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer." Clinical Chemistry 70, no. 1 (2024): 102–15. http://dx.doi.org/10.1093/clinchem/hvad186.

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Abstract Background Increasing evidence implicates microbiome involvement in the development and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of gut or oral microbiota can lead to colonization in the pancreas, resulting in dysbiosis that culminates in release of microbial toxins and metabolites that potentiate an inflammatory response and increase susceptibility to PDAC. Moreover, microbe-derived metabolites can exert direct effector functions on precursors and cancer cells, as well as other cell types, to either promote or attenuate tumor development and

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Spakowicz, Daniel, Rebecca Hoyd, Caroline E. Wheeler, et al. "Pan-cancer analysis of exogenous (microbial) sequences in tumor transcriptome data from the ORIEN consortium and their association with cancer and tumor microenvironment." Journal of Clinical Oncology 40, no. 16_suppl (2022): 3113. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.3113.

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3113 Background: The tumor microbiome holds great potential for its ability to characterize various aspects of cancer biology and as a target for rational manipulation. For many cancer types, little is known about the role of microbes and in what contexts they affect clinical outcomes. Non-human (i.e. exogenous) sequences can be observed in low abundance within high throughput sequencing data of tumors. Here, we describe a collaboration among members of The Oncology Research Information Exchange Network (ORIEN) to leverage tumor biopsy RNAseq data collected under a shared protocol and generate

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Murad, John Paul, Lea Christian, Yukiko Yamaguchi, et al. "Abstract 6676: Microbiome modification impacts PSCA directed chimeric antigen receptor (CAR) T cell therapy for prostate cancer." Cancer Research 84, no. 6_Supplement (2024): 6676. http://dx.doi.org/10.1158/1538-7445.am2024-6676.

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Abstract Background: There is growing evidence that responsiveness to immunotherapy is influenced by the composition of a patient’s gut microbiota. Recent analysis identified strong correlations between abundance of gut microbial species and positive response to immune based therapies in cancer patients. Further, enrichment of commensal microbes can promote immunostimulatory effects, immune based anti-tumor responses, and increased cytotoxic T cell abundance within the TME. Conversely, the presence of gut microbes known to cause inflammatory states in gut tissues may be correlated to negative

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Pani, Giovambattista. "Fusobacterium & Co. at the Stem of Cancer: Microbe–Cancer Stem Cell Interactions in Colorectal Carcinogenesis." Cancers 15, no. 9 (2023): 2583. http://dx.doi.org/10.3390/cancers15092583.

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Adult stem cells lie at the crossroads of tissue repair, inflammation, and malignancy. Intestinal microbiota and microbe–host interactions are pivotal to maintaining gut homeostasis and response to injury, and participate in colorectal carcinogenesis. Yet, limited knowledge is available on whether and how bacteria directly crosstalk with intestinal stem cells (ISC), particularly cancerous stem-like cells (CR-CSC), as engines for colorectal cancer initiation, maintenance, and metastatic dissemination. Among several bacterial species alleged to initiate or promote colorectal cancer (CRC), the pa

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Arnone, Alana, Adam S. Wilson, Valerie S. Payne, and Katherine Ansley. "Abstract 6333: Interactions between endocrine-targeting therapies and short-chain fatty acids in reducing ER+ breast cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 6333. https://doi.org/10.1158/1538-7445.am2025-6333.

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Abstract Emerging evidence highlights the gut microbiome as a key player in estrogen receptor-positive (ER+) breast cancer development and recurrence, with breast cancer patients often exhibiting altered gut microbial profiles. Although oral endocrine-targeting therapies have proven effective in treating and preventing ER+ breast cancer recurrence, the risk of therapeutic resistance and tumor recurrence remains decades post-diagnosis. Whether these endocrine targeting therapies interact to shift the gut microbiome and whether modifying diet-microbe-metabolite interactions could enhance the eff

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Feng, Jia, Kailan Yang, Xuexue Liu, et al. "Machine learning: a powerful tool for identifying key microbial agents associated with specific cancer types." PeerJ 11 (October 23, 2023): e16304. http://dx.doi.org/10.7717/peerj.16304.

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Machine learning (ML) includes a broad class of computer programs that improve with experience and shows unique strengths in performing tasks such as clustering, classification and regression. Over the past decade, microbial communities have been implicated in influencing the onset, progression, metastasis, and therapeutic response of multiple cancers. Host-microbe interaction may be a physiological pathway contributing to cancer development. With the accumulation of a large number of high-throughput data, ML has been successfully applied to the study of human cancer microbiomics in an attempt

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Vadhwana, Bhamini, Munir Tarazi, Piers R. Boshier, and George B. Hanna. "Evaluation of the Oesophagogastric Cancer-Associated Microbiome: A Systematic Review and Quality Assessment." Cancers 15, no. 10 (2023): 2668. http://dx.doi.org/10.3390/cancers15102668.

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Objective. Oesophagogastric cancer is the fifth most common cancer worldwide, with poor survival outcomes. The role of bacteria in the pathogenesis of oesophagogastric cancer remains poorly understood. Design. A systematic search identified studies assessing the oesophagogastric cancer microbiome. The primary outcome was to identify bacterial enrichment specific to oesophagogastric cancer. Secondary outcomes included appraisal of the methodology, diagnostic performance of cancer bacteria and the relationship between oral and tissue microbiome. Results. A total of 9295 articles were identified,

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Spakowicz, Daniel, Rebecca Hoyd, Caroline E. Wheeler, et al. "Abstract PR004: Older adult-specific microbes correlate with treatment response and markers of T-cell senescence in NSCLC." Cancer Research 83, no. 2_Supplement_1 (2023): PR004. http://dx.doi.org/10.1158/1538-7445.agca22-pr004.

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Abstract The gut microbiome changes with age and affects many aspects of human health, including response to cancer treatments. Cancer survival rates have improved with new treatment options, including immune checkpoint blockade (ICB); however, the objective response rate remains low. Manipulation of the microbiome is a promising approach to improving cancer outcomes, but the effect of age is understudied. Here, we sought to understand whether (1) specific microbes are associated with treatment response in older adults with non-small cell lung cancer (NSCLC) and (2) whether these microbes are

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Williams, Nyelia, Rebecca Hoyd, Caroline E. Wheeler, et al. "The effect of the microbiome on immune checkpoint inhibitor toxicity in patients with melanoma." Journal of Clinical Oncology 40, no. 16_suppl (2022): 9568. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.9568.

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9568 Background: Immune-checkpoint inhibitor (ICI) immunotherapy has increased survival in patients with melanoma. However, only half of the patients respond, and many experience immune-related adverse events (irAEs). Recent evidence suggests that modification of the gut microbiome may increase response to ICIs and decrease toxicity. Here we describe the first results of a clinical trial to determine if the microbiome can predict the response or toxicity during the first 16 weeks of ICI treatment. Methods: We enrolled patients aged 18 or older in a prospective observational cohort study at The

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Luo, Wenhao, Zhe Cao, Jiangdong Qiu, Yueze Liu, Lianfang Zheng, and Taiping Zhang. "Novel Discoveries Targeting Pathogenic Gut Microbes and New Therapies in Pancreatic Cancer: Does Pathogenic E. coli Infection Cause Pancreatic Cancer Progression Modulated by TUBB/Rho/ROCK Signaling Pathway? A Bioinformatic Analysis." BioMed Research International 2020 (May 11, 2020): 1–12. http://dx.doi.org/10.1155/2020/2340124.

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Pancreatic cancer (PC) is a pernicious cancer of the digestive system which remains a high degree of malignancy. Increasing studies demonstrated that regulating the gut microbiome may become a brand new strategy to improve the therapeutic outcomes of PC. This study is aimed at obtaining the pathway in the microbial tumorigenesis of PC. Microarray datasets GSE27890, GSE46234, and GSE17610 were downloaded from the GEO (Gene Expression Omnibus) database. Differential analysis was performed for every single gene chip using the R software package (“Limma” package), and functional enrichment analyse

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Loncar, Alexander, Dennis Grencewicz, Rebecca Hoyd, et al. "Abstract 6842: The effect of intra-tumoral Candida albicans on host gene expression." Cancer Research 84, no. 6_Supplement (2024): 6842. http://dx.doi.org/10.1158/1538-7445.am2024-6842.

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Abstract The gut and tumor microbiome have been shown to affect tumorigenesis, tumor immune infiltration, and response to traditional cancer therapeutics such as radiation therapy. Further, specific microbe-cancer relationships have been established. One such microbe is Candida albicans, which has been identified within several gastrointestinal cancers and is associated with an increased risk of metastases and decreased overall survival. By completing RNA-sequencing on murine rectal tumors colonized with C. albicans, we can better understand whether intratumoral changes in gene expression exis

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Oliva, Marc, Nuria Mulet-Margalef, Maria Ochoa-De-Olza, et al. "Tumor-Associated Microbiome: Where Do We Stand?" International Journal of Molecular Sciences 22, no. 3 (2021): 1446. http://dx.doi.org/10.3390/ijms22031446.

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The study of the human microbiome in oncology is a growing and rapidly evolving field. In the past few years, there has been an exponential increase in the number of studies investigating associations of microbiome and cancer, from oncogenesis and cancer progression to resistance or sensitivity to specific anticancer therapies. The gut microbiome is now known to play a significant role in antitumor immune responses and in predicting the efficacy of immune-checkpoint inhibitors in cancer patients. Beyond the gut, the tumor-associated microbiome—microbe communities located either in the tumor or

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Cavallucci, Virve, Ivana Palucci, Marco Fidaleo, et al. "Proinflammatory and Cancer-Promoting Pathobiont Fusobacterium nucleatum Directly Targets Colorectal Cancer Stem Cells." Biomolecules 12, no. 9 (2022): 1256. http://dx.doi.org/10.3390/biom12091256.

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Intestinal bacterial communities participate in gut homeostasis and are recognized as crucial in bowel inflammation and colorectal cancer (CRC). Fusobacterium nucleatum (Fn), a pathobiont of the oral microflora, has recently emerged as a CRC-associated microbe linked to disease progression, metastasis, and a poor clinical outcome; however, the primary cellular and/or microenvironmental targets of this agent remain elusive. We report here that Fn directly targets putative colorectal cancer stem cells (CR-CSCs), a tumor cell subset endowed with cancer re-initiating capacity after surgery and che

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Shi, Shuo, Yuwen Chu, Haiyan Liu, et al. "Predictable regulation of survival by intratumoral microbe-immune crosstalk in patients with lung adenocarcinoma." Microbial Cell 11 (2024): 29–40. http://dx.doi.org/10.15698/mic2024.02.813.

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Intratumoral microbiota can regulate the tumor immune microenvironment (TIME) and mediate tumor prognosis by promoting inflammatory response or inhibiting anti-tumor effects. Recent studies have elucidated the potential role of local tumor microbiota in the development and progression of lung adenocarcinoma (LUAD). However, whether intratumoral microbes are involved in the TIME that mediates the prognosis of LUAD remains unknown. Here, we obtained the matched tumor microbiome and host transcriptome and survival data of 478 patients with LUAD in The Cancer Genome Atlas (TCGA). Machine learning

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Williams, Nyelia, Caroline E. Wheeler, Marium Husain, et al. "De-correlating immune checkpoint inhibitor toxicity and response in melanoma via the microbiome." Journal of Clinical Oncology 41, no. 16_suppl (2023): 9569. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.9569.

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9569 Background: Immune-checkpoint inhibitor (ICI) immunotherapy increases survival in patients with melanoma. Yet only half of the patients respond, and 10-40% of patients experience immune-related adverse events (irAEs). Previous studies have found a correlation between the development of an irAE and treatment response. Modifying the gut microbiome could positively affect response to ICIs and reduce toxicities. We sought to determine if the microbiome at the onset of treatment, during an irAE, and at 12 weeks, can predict the response or toxicity during ICI treatment for metastatic melanoma.

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Su, Yanfang, Shiyu Li, Die Sang, and Yurong Zhang. "Association of tissue microbiota with cancer stages in lung adenocarcinoma." Journal of Clinical Oncology 42, no. 16_suppl (2024): e20061-e20061. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e20061.

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e20061 Background: There has been a lack of comprehensive investigation into changes in the tissue microbial environment at various stages of lung adenocarcinoma (LUAD). This study aims to identify and analyze microbial markers that show significant differences at different stages of LUAD and to assess their impact on the tumor microenvironment. Methods: Microbiome data, gene expression, and clinical information from LUAD patient tissues were retrieved by reanalyzing the sample sequencing data from the Cancer Genome Atlas (TCGA) database, as conducted by Rob Knight’s group. The samples, catego

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Nandi, Deeptashree, Sheetal Parida, Sowjanya Thatikonda, et al. "Abstract 5905: Enterotoxigenic Bacteroides fragilis, a colon microbe, dysregulates polyamine catabolism to promote breast cancer progression." Cancer Research 83, no. 7_Supplement (2023): 5905. http://dx.doi.org/10.1158/1538-7445.am2023-5905.

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Abstract Background: With more than 2.3 million cases worldwide, breast cancer persists as a major health burden and warrants a greater understanding of the molecular triggers underlying this disease. Focusing on microbial dysbiosis, our lab discovered the pivotal role of the enterotoxigenic Bacteroides fragilis (ETBF) in promoting breast tumorigenesis through activation of key oncogenic pathways. A gap in knowledge exists regarding how microbes/microbial toxins modulate the oncogenic pathways in cancer cells. Polyamines are imperative for various physiological processes, including cell growth

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Hamada, Masakazu, Hiroaki Inaba, Kyoko Nishiyama, et al. "Potential Role of the Intratumoral Microbiota in Prognosis of Head and Neck Cancer." International Journal of Molecular Sciences 24, no. 20 (2023): 15456. http://dx.doi.org/10.3390/ijms242015456.

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The tumor microbiome, a relatively new research field, affects tumor progression through several mechanisms. The Cancer Microbiome Atlas (TCMA) database was recently published. In the present study, we used TCMA and The Cancer Genome Atlas and examined microbiome profiling in head and neck squamous cell carcinoma (HNSCC), the role of the intratumoral microbiota in the prognosis of HNSCC patients, and differentially expressed genes in tumor cells in relation to specific bacterial infections. We investigated 18 microbes at the genus level that differed between solid normal tissue (n = 22) and pr

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Zeng, Huawei, Shahid Umar, Bret Rust, Darina Lazarova, and Michael Bordonaro. "Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer." International Journal of Molecular Sciences 20, no. 5 (2019): 1214. http://dx.doi.org/10.3390/ijms20051214.

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Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial metabolites in the colon, cause opposing effects on colonic inflammation at chronically high physiological levels. Primary BAs play critical roles in cholesterol metabolism, lipid digestion, and host–microbe interaction. Although BAs are reabsorbed via enterohepatic circulation, primary BAs serve as substrates for bacterial biotransformation to secondary BAs in the colon. High-fat diets increase secondary BAs, such as deoxycholic acid (DCA) and lithocholic acid (LCA), which are risk factors for colonic

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Wheeler, Caroline E., Samuel Coleman, Rebecca Hoyd, et al. "Abstract 5904: Intra-tumor microbes identified by RNAseq associated with response to immune checkpoint blockade in metastatic melanoma." Cancer Research 83, no. 7_Supplement (2023): 5904. http://dx.doi.org/10.1158/1538-7445.am2023-5904.

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Abstract The tumor microbiome has recently been shown to play a key role in the context of oncogenesis, cancer immune phenotype, cancer progression and treatment outcomes in a variety of cancers. We investigated the possible associations between tumor microbiome and successful treatment outcomes with immune checkpoint blockade (ICB) in patients with metastatic melanoma. We evaluated RNAseq from tumor samples, collected prior to the start of treatment with ICB, from 71 patients with metastatic melanoma. Samples were provided by eight members of the Oncology Research Information Exchange Network

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Yusuf, Kafayat, Venkatesh Sampath, and Shahid Umar. "Bacterial Infections and Cancer: Exploring This Association And Its Implications for Cancer Patients." International Journal of Molecular Sciences 24, no. 4 (2023): 3110. http://dx.doi.org/10.3390/ijms24043110.

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Bacterial infections are common in the etiology of human diseases owing to the ubiquity of bacteria. Such infections promote the development of periodontal disease, bacterial pneumonia, typhoid, acute gastroenteritis, and diarrhea in susceptible hosts. These diseases may be resolved using antibiotics/antimicrobial therapy in some hosts. However, other hosts may be unable to eliminate the bacteria, allowing them to persist for long durations and significantly increasing the carrier's risk of developing cancer over time. Indeed, infectious pathogens are modifiable cancer risk factors, and throug

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Tosado-Rodríguez, Eduardo, Loyda B. Mendez, Ana M. Espino, et al. "Inflammatory cytokines and a diverse cervicovaginal microbiota associate with cervical dysplasia in a cohort of Hispanics living in Puerto Rico." PLOS ONE 18, no. 12 (2023): e0284673. http://dx.doi.org/10.1371/journal.pone.0284673.

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Cervical cancer (CC) is women’s fourth most common cancer worldwide. A worrying increase in CC rates in Hispanics suggests that besides Human papillomavirus infections, there may be other cofactors included in the epithelial microenvironment that could play a role in promoting the disease. We hypothesized that the cervical microbiome and the epithelial microenvironment favoring inflammation is conducive to disease progression in a group of Hispanics attending gynecology clinics in Puerto Rico. Few studies have focused on the joint microbiota and cytokine profile response in Hispanics outside t

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Holmes, Laurens, Jasmine Rios, Betyna Berice, et al. "Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis." Medicines 8, no. 1 (2021): 1. http://dx.doi.org/10.3390/medicines8010001.

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Helicobacter pylori (H. pylori) is a bacterial pathogen implicated in gastritis, gastric ulceration, and gastric carcinoma. This study aimed to synthesize literature in providing evidence on the causative role of H. pylori in gastric carcinoma development. This study is based on assessing public literature using an applied meta-analysis, namely, quantitative evidence synthesis (QES). The analytic procedure uses DerSimonian-Laird, including assessing heterogeneity. The QES also utilizes meta-regression and the environmental effect associated with H. pylori in gastric cancer development. Eightee

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Kustrimovic, Natasa, Giorgia Bilato, Lorenzo Mortara, and Denisa Baci. "The Urinary Microbiome in Health and Disease: Relevance for Bladder Cancer." International Journal of Molecular Sciences 25, no. 3 (2024): 1732. http://dx.doi.org/10.3390/ijms25031732.

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Bladder cancer (BC) constitutes one of the most diagnosed types of cancer worldwide. Advancements in and new methodologies for DNA sequencing, leading to high-throughput microbiota testing, have pinpointed discrepancies in urinary microbial fingerprints between healthy individuals and patients with BC. Although several studies suggest an involvement of microbiota dysbiosis in the pathogenesis, progression, and therapeutic response to bladder cancer, an established direct causal relationship remains to be elucidated due to the lack of standardized methodologies associated with such studies. Thi

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Panneerselvam, Janani, Venkateshwar Madka, Rajani Rai, et al. "Inflammatory Mediators and Gut Microbial Toxins Drive Colon Tumorigenesis by IL-23 Dependent Mechanism." Cancers 13, no. 20 (2021): 5159. http://dx.doi.org/10.3390/cancers13205159.

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Obesity-associated chronic inflammation predisposes colon cancer risk development. Interleukin-23 (IL-23) is a potential inflammatory mediator linking obesity to chronic colonic inflammation, altered gut microbiome, and colon carcinogenesis. We aimed to elucidate the role of pro-inflammatory eicosanoids and gut bacterial toxins in priming dendritic cells and macrophages for IL-23 secretion to promote colon tumor progression. To investigate the association of IL-23 with obesity and colon tumorigenesis, we utilized TCGA data set and colonic tumors from humans and preclinical models. To understan

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Banerjee, Anik, Christina Roland, Sarah Johnson, Nadim Ajami, and Jennifer Wargo. "Abstract 5906: Gut microbiota signatures are associated with immunotherapy induced cognitive decline and neurotoxicity." Cancer Research 83, no. 7_Supplement (2023): 5906. http://dx.doi.org/10.1158/1538-7445.am2023-5906.

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Abstract Studies have demonstrated promising outcomes of combined immune checkpoint blockade (CICB) modulating tumor cytotoxicity via targeting cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death 1 (PD-1). The emergence of long-term patient management has been transformed among health care professionals as patient survival rates are increasing significantly. Despite promising advances, patient outcomes are heterogenic and are correlative to host intrinsic and extrinsic factors. Multiple reports have highlighted the negative effects of cancer treatments towards induci

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Bhowmick, Krishanu, Kazufumi Ohshiro, Xiyan Xiang та ін. "Abstract 753: CEACAM1 induces microbiome and metabolite driven diversion of TGF-β signaling to promote colon cancer". Cancer Research 84, № 6_Supplement (2024): 753. http://dx.doi.org/10.1158/1538-7445.am2024-753.

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Abstract Background: Colon cancer is rising in younger individuals in the United States. Potential causal factors are altered diets and gut microbiomes. Yet key signaling pathways, host-microbe interactions, and metabolites such as ammonia in cancer remain unclear. CEACAM1 responds to pathogenic microbes, interacts with the TGF-β/SPTBN1 and levels are raised in invasive colon cancer. Alterations in the TGF-β pathway occur ~40% of human GI cancers, and mouse models with disrupted TGF-β signaling (Tgfbr2−/−, Smad4+/−Sptbn1+/−, and Tgfb1−/−) develop colorectal cancer (CRC) that is dependent upon

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Shi, Zhongcheng, Robert S. Fultz, Melinda A. Engevik, et al. "Distinct roles of histamine H1- and H2-receptor signaling pathways in inflammation-associated colonic tumorigenesis." American Journal of Physiology-Gastrointestinal and Liver Physiology 316, no. 1 (2019): G205—G216. http://dx.doi.org/10.1152/ajpgi.00212.2018.

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Inflammatory bowel disease (IBD) is a well-known risk factor for the development of colorectal cancer. Prior studies have demonstrated that microbial histamine can ameliorate intestinal inflammation in mice. We tested the hypothesis whether microbe-derived luminal histamine suppresses inflammation-associated colon cancer in Apcmin/+ mice. Mice were colonized with the human-derived Lactobacillus reuteri. Chronic inflammation was induced by repeated cycles of low-dose dextran sulfate sodium (DSS). Mice that were given histamine-producing L. reuteri via oral gavage developed fewer colonic tumors,

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Rodríguez, Eduardo Lemuel Tosado, Anelisse Dominicci-Maura, Loyda Mendez, Stephanie Dorta, Josefina Romaguera та Filipa Godoy-Vitorino. "Abstract 712: Cytokine and TGF-β levels are associated with changes in cervicovaginal microbiota in a cohort of Caribbean women". Cancer Research 82, № 12_Supplement (2022): 712. http://dx.doi.org/10.1158/1538-7445.am2022-712.

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Abstract Recent studies suggest that the cervical microbiome can strongly influence inflammation and pre-cancerous lesion progression. However, research focused on understanding the role of microbial communities in the progression of pre-cancerous lesions to cancer in Latino women is scarce. We aimed to investigate the relationship between the cervicovaginal microbiome and inflammation while considering cervical neoplasia and HPV infection in Puerto Rican women. We collected cervical swabs and lavages from 142 participants coming to colposcopy clinics in San Juan, Puerto Rico. Genomic DNA was

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Cook, Katherine L., Erin Giles, Amy Kreutzjans, et al. "Abstract PO5-14-01: Weight loss and omega-3 polyunsaturated fatty acid intervention in overweight and obese peri- and postmenopausal women with increased breast cancer risk modifies the gut microbiome and is associated with circulating biomarkers." Cancer Research 84, no. 9_Supplement (2024): PO5–14–01—PO5–14–01. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-14-01.

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Abstract Background: Obesity-associated gut microbiome dysbiosis is thought to increase risk for postmenopausal breast cancer through alteration of estrogen metabolism and an increase in pro-inflammatory microbe abundance. Many studies have reported an increase in the Firmicutes/Bacteroidetes phyla ratio as a biomarker of obesity and is associated with adverse metabolic outcomes. Marine omega-3 eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids are thought to have favorable metabolic and inflammation resolving properties resulting in reduced risk for several epithelial cancers. One p

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Ruiz, Christian F., Rylee McDonnell, Lauren Lawres, et al. "Abstract C048: Obesity transforms the gut microbiome to invoke a cancer permissive state." Cancer Research 84, no. 2_Supplement (2024): C048. http://dx.doi.org/10.1158/1538-7445.panca2023-c048.

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Abstract Obesity – an established, modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC) – has increased in prevalence worldwide yet the precise mechanisms underlying its propensity to promote cancer have remained an enigma. Alterations to the gut microbiota, the microorganisms that colonize the intestinal tract of humans and mice, may provide a link between obesity and PDAC, offering a previously untapped target to develop novel anti-cancer strategies in this highly lethal disease. To ascertain the importance of the obesity-associated microbiome in PDAC progression, we leveraged

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Cavadas, Bruno, Rui Camacho, Joana C. Ferreira, et al. "Gastric Microbiome Diversities in Gastric Cancer Patients from Europe and Asia Mimic the Human Population Structure and Are Partly Driven by Microbiome Quantitative Trait Loci." Microorganisms 8, no. 8 (2020): 1196. http://dx.doi.org/10.3390/microorganisms8081196.

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The human gastrointestinal tract harbors approximately 100 trillion microorganisms with different microbial compositions across geographic locations. In this work, we used RNASeq data from stomach samples of non-disease (164 individuals from European ancestry) and gastric cancer patients (137 from Europe and Asia) from public databases. Although these data were intended to characterize the human expression profiles, they allowed for a reliable inference of the microbiome composition, as confirmed from measures such as the genus coverage, richness and evenness. The microbiome diversity (weighte

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Uzelac, Matthew, Yuxiang Li, Jaideep Chakladar, Wei Tse Li, and Weg M. Ongkeko. "Archaea Microbiome Dysregulated Genes and Pathways as Molecular Targets for Lung Adenocarcinoma and Squamous Cell Carcinoma." International Journal of Molecular Sciences 23, no. 19 (2022): 11566. http://dx.doi.org/10.3390/ijms231911566.

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The human microbiome is a vast collection of microbial species that exist throughout the human body and regulate various bodily functions and phenomena. Of the microbial species that exist in the human microbiome, those within the archaea domain have not been characterized to the extent of those in more common domains, despite their potential for unique metabolic interaction with host cells. Research has correlated tumoral presence of bacterial microbial species to the development and progression of lung cancer; however, the impacts and influences of archaea in the microbiome remain heavily un

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