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Dissertations / Theses on the topic 'Cancer of mammary gland'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Pascual, Domingo Rosa. "CPEB2 in mammary gland homeostasis and breast cancer." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/586313.

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The mammary gland develops postnatally and is remodeled, during each estrous cycle and pregnancy, through very dynamic expansions and involutions of its polarized epithelial tree. Moreover, the mammary gland is hierarchically organized, where the two main epithelial populations may arise from a common bipotent mammary stem cell (MaSC). The principal epithelial cell types in the mammary gland are luminal cells and myoepithelial cells (also named basal cells), which are found surrounding luminal cells and in contact with the extracellular matrix. Further, the luminal compartment has two main li

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2

Artibani, Mara. "WT1 role in mammary gland and breast cancer biology." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/21036.

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The Wilms' Tumour Suppressor gene 1, WT1, encodes for a complex protein which is essential in mammals throughout life. Its roles vary with the developmental stages: in the embryo, it regulates the epithelial-mesenchymal balance required for a correct organogenesis and acts as a tumour suppressor; in the adult, it is involved in the maintenance of tissue homeostasis and has been controversially considered as an oncogene. Breast cancer is one of the adult tumours in which WT1 oncogenic function was first hypothesised. This malignancy is the most common in women, with more than one million cases

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3

Dawson, Simon Paul. "Genes expressed in the lactating rabbit mammary gland." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335293.

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4

Kutanzi, Kristy, and University of Lethbridge Faculty of Arts and Science. "The role of epigenetics in the rat mammary gland." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010, 2010. http://hdl.handle.net/10133/2492.

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Epigenetics plays an important role in carcinogenesis with heritable changes in DNA methylation and histone modifications intricately linked to the initiation, promotion, and progression of cancer. Evidence shows that a number of chemical and physical agents can induce epigenetic changes during carcinogenesis. Two such agents, estrogen and ionizing radiation, are generally recognized as being carcinogenic. Yet the epigenetic repercussions of these carcinogens remain relatively unknown. More importantly, the combined effect of these carcinogens has never been addressed in vivo from an epigeneti

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5

Knostman, Katherine A. B. "Sodium/iodide symporter regulation by oncogenes in the mammary gland and thyroid gland using mouse models." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1181659993.

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6

Staniszewska, Anna Dominika. "Roles of Stat3 in mammary gland development, involution and breast cancer." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610277.

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7

Ferrari, Nicola. "Investigating RUNX transcription factors in mammary gland development and breast cancer." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4790/.

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Breast cancer is the third most common cause of cancer death in the UK, accountable for more than 11000 deaths in 2010 alone (www.cancerresearchuk. org). Developmental pathways commonly required for normal development are often hijacked during tumour progression, so a better understanding of mammary gland development is necessary to fully understand the roots of breast cancer. The Runx gene family are known to be important regulators of development in different lineages. In particular RUNX1 and RUNX2 have been widely studied in the context of haematopoiesis and osteogenesis respectively, but t

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8

Charifou, Elsa. "Characterization and impact of cellular senescence during mammary gland involution." Electronic Thesis or Diss., Sorbonne université, 2022. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2022SORUS559V2.pdf.

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La sénescence est une réponse à un stress biologique, caractérisée par un arrêt stable du cycle cellulaire. Néanmoins, les cellules restent métabolliquement actives et acquièrent un phenotype sécrétoire associé à la sénescence, avec la production d’un sécrétome complexe composé de cytokines, chémiokines, facteurs de croissance et modulateurs du remodelage de la matrice extracellulaire. La sénescence est associée à de nombreux processus pathologiques, comme la tumorigénèse et le vieillessement. Cependant, où, quand et comment la sénescence contribue aux processus physiologiques reste méconnu. P

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9

Williams, Rebecca. "The role of the Edar signalling pathway in mammary gland development and tumourigenesis." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-the-edar-signalling-pathway-in-mammary-gland-development-and-tumourigenesis(2cfad486-e1ad-4f70-9c39-212e2c6a0c6c).html.

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Edar is a member of the death receptor subfamily of TNF receptors that plays an important role in the development of ectodermal appendages. Mutations in this signalling pathway cause the developmental disorder hypohidrotic ectodermal dysplasia (HED). HED has a similar phenotype in a number of mammals, and includes improper development of ectodermal appendages such as hair, teeth and glands. Edar signalling has not previously been linked with tumourigenesis, however, increased NFĸB signalling has been associated with a number of cancers, including breast cancer, and is known to be downstream of

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10

Bernardo, Gina M. "Discerning the Role of FOXA1 in Mammary Gland Development and Breast Cancer." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1315607905.

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11

Ruiz-Torres, Sasha J. "Role of HGFL-RON Signaling in Mammary Gland Development and Breast Cancer." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543920539146247.

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12

Girnius, Nomeda A. "The cJUN NH2-terminal kinase pathway in mammary gland biology and carcinogenesis." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/961.

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The cJUN NH2-terminal kinase (JNK) pathway responds to environmental stresses and participates in many cellular processes, including cell death, survival, proliferation, migration, and genome maintenance. Importantly, genes that encode components of the JNK signaling pathway are frequently mutated in human breast cancer, but the functional consequence of these mutations in mammary carcinogenesis is unclear. Anoikis – suspension-induced apoptosis – has been implicated in oncogenic transformation and tumor cell metastasis. Anoikis also contributes to lumen formation during mammary gland developm

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13

Jobling, Stephanie. "The Notch and EDAR signalling pathways in mammary gland development and tumourigenesis." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/the-notch-and-edar-signalling-pathways-in-mammary-gland-development-and-tumourigenesis(69b68d49-9f6b-4e98-8521-a21f3af3c4fb).html.

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Worldwide, more than 1,000,000 women develop breast cancer each year, and more than 400,000 die because of it. Basal-like breast cancers, which account for 8% to 20% of all breast cancer cases, represent the most aggressive of breast cancers with the majority resistant to existing targeted therapies. Accumulating lines of evidence implicate the Notch pathway in the aetiology of these basal-like breast cancers; while current work in our lab supports the notion that signalling through the Ectodermal Dysplasin Receptor (EDAR) pathway is also important. Notch signalling functions in normal develop

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14

Schmidt, Xénia. "TOX3 – A candidate breast cancer predisposition gene." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21831/document.

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Deux tiers des cancers du sein expriment le récepteur à l’estrogène alpha (REα) et leur croissance dépend des estrogènes alors que l’expression de REα induit la différenciation et la sénescence des cellules humaines mammaires épithéliales normales. Le développement embryonnaire et la différenciation de la glande mammaire adulte sont contrôlés par des facteurs de transcription, dont beaucoup sont aussi impliqués dans la tumorigenèse. Plusieurs études d'association pan-génomiques ont identifié le putatif facteur de transcription TOX high mobility group box family member 3 (TOX3) comme un nouveau

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15

Pai, Vaibhav Prakash. "Serotonin Regulation of Mammary Gland Involution and its Role in Breast Cancer Progression." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1237565289.

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16

Johnson, Abby L. "Vitamin D3 Receptor Signaling in Mammary Gland Development and Ron-Mediated Breast Cancer." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1416230815.

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17

Yuan, Yan. "Potential roles of lutein in mammary gland development and breast cancer cell growth." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1513374861687537.

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18

Oakes, Samantha Richelle St Vincent's Clinical School UNSW. "Investigation of the role of prolactin in mammary gland development and carcinogenesis." Awarded by:University of New South Wales. St. Vincent's Clinical School, 2006. http://handle.unsw.edu.au/1959.4/28846.

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The pituitary hormone prolactin (Prl) is essential for alveolar morphogenesis and plays a role in breast carcinogenesis, however the mechanism that underlies these actions remains to be defined. Alterations in serum Prl provide the primary endocrine signal regulating developmental events in the mammary gland in sexually mature mammals. Prl production and post-translational phosphorylation by the pituitary is regulated by the neuropeptide Galanin (Gal) in response to hypothalamic signals integrating neuronal and endocrine inputs. Prl exerts its effects on the mammary epithelium in two ways, ind

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19

Benítez, Sandra. "New insights into RANK signaling pathway in the mammary gland." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673589.

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Receptor activator of nuclear factor kappa-β ligand (RANKL) and its receptor RANK are key mediators of bone resorption1,2. RANKL, its receptor RANK and its natural decoy receptor OPG, which is a competitive inhibitor that binds to RANKL and negatively regulates the pathway3, are members of the tumor necrosis factor (TNF) superfamily. Based on this key role in bone remodeling, a monoclonal antibody against RANKL, called denosumab, has been developed and is used in the clinics for the treatment of osteoporosis and bone metastasis. Moreover, RANK pathway is not only essential for bone remodeling

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20

Sharma, Puja. "High Sugar Consumption Results in Mammary Epithelial Hyperplasia and Adipocyte Hypertrophy in a Mouse Model of Hyperglycemia." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593268272488285.

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21

vanGils, Louderbough Jeanne Marguerite. "CD44 and Hyaluronan in the Regulation of Mammary Gland Development and Breast Cancer Progression." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/146075.

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Metastasis is the leading cause of death in patients with cancer, and the extracellular matrix is critical to cancer dissemination. The adhesion receptor, CD44, mediates cellular communication with the extracellular matrix by binding to the glycosaminoglycan, hyaluronan (HA). CD44 and HA play critical roles in cancer progression and development. HA is deposited in extracellular and pericellular matrices where it directs intracellular signaling through interactions with cell-surface CD44. CD44-HA interactions, in turn, direct signaling that is relevant to cancer progression. Importantly, t

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22

Jenkinson, Sarah Rhiannon. "In vitro models to study the role of S100A4 in mammary epithelial cell metastasis." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367678.

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23

Ramamoorthy, Sivapriya. "Role of E6-Associated Protein (E6-AP) in Mammary Gland Development and Tumorigenesis." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/272.

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E6-associated protein (E6-AP), which was originally identified as an ubiquitin-protein ligase, also functions as a co-activator that enhances the hormone-dependent transactivation of estrogen (ER) and progesterone (PR) receptors. To investigate the in vivo role of E6-AP in mammary gland development, we generated transgenic mouse lines that specifically overexpress either wild-type human E6-AP (E6-APWT) or the ubiquitin-protein ligase defective mutant E6-AP (E6-APC833S) in the mammary gland. Here we show that overexpression of E6-APWT results in impaired mammary gland development. In contrast,

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24

MUNGO, GIORGIA. "ROLE OF p27Kip1 IN MAMMARY GLAND DEVELOPMENT AND TUMORIGENESIS IN Δ16HER2 MODEL". Doctoral thesis, Università degli Studi di Trieste, 2020. http://hdl.handle.net/11368/2963754.

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Breast Cancer is the most frequent cancer among women worldwide. The oncogene HER2 is amplified and overexpressed in about 15-20% of invasive BC and is associated with poor prognosis. A splice variant of the human HER2 gene, the Δ16HER2, displaying enhanced transforming activity, has been identified in BC patients. p27kip1 is a well-known cell cycle inhibitor whose expression is frequently downmodulated in tumors, including BC. However, its role in HER2 BC remains elusive and we thus decided to investigate the impact of p27 loss in Δ16HER2-driven breast cancer onset and progression. Δ16HER2p27

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25

Schmidt, Xenia. "TOX3 : a candidate breast cancer predisposition gene." Thesis, University of St Andrews, 2012. http://hdl.handle.net/10023/3104.

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26

Creer, Anna Elisabeth. "The EGF receptor family : intracellular targeting in vitro and their role in mammary gland development." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325523.

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27

Hume, Robert David. "Recapitulating mammary gland development and breast cancer cell migration in vitro using 3D engineered scaffolds." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/271099.

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The adult mammary gland is comprised of a bi-layered epithelium of luminal and myoepithelial cells surrounded by an adipocyte-rich fat pad, a highly collagenous extra-cellular matrix (ECM) and a number of other stromal and endothelial cell types. Mammary stem cells (MaSCs) reside within the epithelium and these are capable of repopulating a mammary fat pad that is devoid of epithelium, upon transplantation. It was sought to recapitulate this process of MaSCs repopulating a fat pad using a synthetic fat pad, engineered from a collagen scaffold invested with adipocytes, to provide an in vitro 3D

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28

McRae, Dorothy A., and University of Lethbridge Faculty of Arts and Science. "Radiation induced epigenetic dysregulation in rat mammary gland tissue / Dorothy A. McRae." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010, 2010. http://hdl.handle.net/10133/2615.

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Most breast cancer patients undergo radiation diagnostics and are also treated with radiotherapy. In addition to being an important treatment modality, ionizing radiation (IR) is a potent tumour-causing agent that has been linked to breast cancer development. However, the exact molecular etiology of IR-induced mammary gland carcinogenesis remains unknown. We set out to analyze the role of DNA methylation in mammary gland responses to low dose IR using a well-established rat model. We also studied low dose IR effects on global gene expression and microRNAome. We found that exposure to low, mamm

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29

PASI, CRISTINA ELISABETTA. "DISSECTING THE TRANSFORMATION PROCESS IN MAMMARY STEM CELLS." Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/155503.

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Stem Cells (SCs) may play a critical role in cancer development, yet the direct demonstration is still lacking. The characterization of mechanisms that sustain and regulate Cancer Stem Cells (CSCs) may help elucidating their role in tumors. Using a MMTV-ErbB2 breast cancer mouse-model, we had previously shown that CSCs, through multiple rounds of symmetric divisions and extended self-renewal, drive tumor growth and the expansion of the CSC pool. Critical for this property is the lack of functional p53, that drives CSCs to symmetric divisions. Here we show that symmetric divisions and extended

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30

Jones, Caitlin. "Stromal PTEN Expression Regulates Extracellular Matrix Deposition and Organization in the Mammary Gland." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1585750384613682.

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31

Park, Jung. "The transcription factor activator protein family of genes in mammary gland development and breast cancer progression." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/5596.

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Breast cancer is currently the second most common form of cancer and the second leading cause of death due to cancer in the United States. Breast cancer itself is subdivided into at least four subtypes, luminal A, luminal B, HER2-enriched, and basal-like, based on genomewide molecular expression patterns. Luminal A is the most common form and typically characterized by high levels of estrogen receptor (ER). HER2-enriched cancers usually, but not always, harbor amplified copies of the HER2 oncogene. Luminal B cancers share characteristics with the luminal A and HER2-enriched subtypes. Finally,

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32

Hindman, Andrea R. "The mechanisms of BPA exposure and in the developing mammary gland." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1503321233777122.

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33

Bresson, Laura. "Rôle de la Podoplanine dans le développement et la tumorigenèse mammaires." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS403/document.

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L’épithélium mammaire est composé de cellules luminales et basales myoépithéliales. Il comprend des cellules souches et progénitrices qui gouvernent le développement de la glande. Leur dérégulation est probablement à l’origine de certains cancers du sein très agressifs, dits « triple-‐négatifs » (négatifs pour les récepteurs hormonaux et HER2), pour lesquels il n’existe pas de thérapie ciblée. L’équipe a identifié un nouveau marqueur spécifique du compartiment basal comprenant les cellules souches, la Podoplanine (Pdpn), dont l’expression est concentrée aux contactsintercellulaires basal-‐lu

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34

Song, Xiaozheng. "Estrogen Receptor Beta Is A Negative Regulator Of Mammary Cell Proliferation." ScholarWorks @ UVM, 2014. http://scholarworks.uvm.edu/graddis/259.

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The mammary gland cell growth and differentiation are under the control of both systemic hormones and locally produced growth factors. Among all these important hormones and growth factors, estrogen plays a central role in mammary gland development. The biological function of estrogen is mediated by estrogen receptor α (ERα) and estrogen receptor β (ERβ). Both ERα and ERβ are expressed in the mammary gland, but with distinct expression patterns. In the mammary gland, ERα has been proved to be the estrogen receptor that mediates the mitogenic function of estrogen. However the function of ERβ in

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35

Clément, Flora. "Regulating human mammary epithelial stem cells transformation : an interplay between extrinsic and intrinsic signals." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1078.

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L'incidence, le coût et l'issue fatale dans un nombre encore trop élevé de cas font du cancer un problème majeur en santé publique. Malgré les progrès réalisés dans le développement de thérapies ciblées, la plupart des cancers rechutent, vraisemblablement à cause de l'échappement des cellules souches cancéreuses (CSC) qui survivent et régénèrent la tumeur. L'enjeu clinique en cancérologie aujourd'hui est d'éliminer les cellules souches cancéreuses en épargnant les cellules souches normales. Pour atteindre cet objectif, il est primordial de comprendre leurs mécanismes spécifiques de transformat

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36

Hammer, Anisha Mathur. "Elucidating the Roles of Stromal PDGF-receptors alpha and beta in Mammary Gland Development and Carcinogenesis." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492446436437557.

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37

Sammarco, Alessandro. "Study on normal and tumoral cell subpopulations and their interactions in the mammary gland cancer of humans and animals." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3425737.

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Human breast cancer (HBC), canine (CMT), and feline mammary tumors (FMT) are extremely common and are characterized by a remarkable both inter- and intra-tumor heterogeneity. Intra-tumor heterogeneity is due to the coexistence of cancer cells that differ between each other in terms of phenotypic, genetic, behavioral characteristics, and metastatic potential. Cancer stem cells (CSCs) are thought to be responsible for such heterogeneity, resistance to therapy, and metastasis development. Several pathways are altered in CSCs, such as the oncogenic Wnt/-catenin and Hippo pathways, and CSCs are ass

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38

Романюк, Анатолій Миколайович, Анатолий Николаевич Романюк, Anatolii Mykolaiovych Romaniuk та ін. "Особливості діагностики медулярного і протокового інфільтративного раку молочної залози в морфологічній практиці". Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/26809.

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Андрющенко, Володимир Вікторович, Владимир Викторович Андрющенко, Volodymyr Viktorovych Andriushchenko, Артем Іванович Гребенюк, Артем Иванович Гребенюк та Artem Ivanovych Hrebeniuk. "Лікування ускладнень після мастектомії у хворих на рак молочної залози". Thesis, Вид-во СумДУ, 2007. http://essuir.sumdu.edu.ua/handle/123456789/5074.

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Андрющенко, Володимир Вікторович, Владимир Викторович Андрющенко, Volodymyr Viktorovych Andriushchenko, А. Д. Саенко та Г. А. Журбенко. "Диагностика и лечение рака молочной железы". Thesis, Издательство СумГУ, 1997. http://essuir.sumdu.edu.ua/handle/123456789/25094.

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Романюк, С. А., Микола Сергійович Линдін, Николай Сергеевич Лындин та Mykola Serhiiovych Lyndin. "Особливості гормональної залежності раку молочної залози у жінок різного віку". Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/26872.

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Сокрут, Б. Є., Ю. Е. Марченко та В. О. Бевз. "Сучасний погляд на гормонзалежні форми інвазивного раку молочної залози. Особливості та статистика захворюванння у Вінницькій області". Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/45017.

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Мета: дослідити захворюваність на інвазивні форми раку молочної залози у Вінницькій області та порівняти із загальноукраїнськими показниками. Визначити частку гормонозалежного раку із загальної кількості випадків за результатами імуногістологічного аналізу пухлин молочної залози.

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Трофимець, Д. О., А. С. Чернишенко, А. О. Прилуцький, В. Г. Шлопов та Л. І. Волос. "Патоморфологічні особливості низько- та недиференційованого раку молочної залози". Thesis, Видавництво СумДУ, 2008. http://essuir.sumdu.edu.ua/handle/123456789/11313.

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Santoro, A. "A ROLE FOR MYC IN THE SELF RENEWAL OF MAMMARY STEM CELLS AND CANCER STEM CELLS." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/365891.

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Cancer Stem Cells (CSCs) are a clinically relevant population at the apex of the inner hierarchical organization of many tumors. It was previously demonstrated by our group that loss of the p53 tumor suppressor leads to an increase in the mammary stem cell (MaSC) and breast CSC content, due to a switch of the mode of division from mainly asymmetric to symmetric. However, which of the many pathways instructed by p53 is directly involved in the execution of this biological phenotype remains to be determined. Following a candidate gene approach, we investigated Myc as the putative key downstream

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Meyer, Sara. "The Ron Receptor Tyrosine Kinase in Tissue Morphogenesis." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1258666269.

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Gaiko-Shcherbak, Aljona [Verfasser]. "Functional and Mechanical in vitro Analyses of the Mammary Gland Basement Membrane as a Barrier During Cancer Invasion / Aljona Gaiko-Shcherbak." Bonn : Universitäts- und Landesbibliothek Bonn, 2019. http://d-nb.info/1188732315/34.

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47

Gagniac, Laurine. "Physiologie et physiopathologie des effets membranaires du récepteur des œstrogènes alpha (ERα) dans la glande mammaire". Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30101.

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It is well established that the 17-estradiol is involved in the development and homeostasis of reproductive and extra-reproductive tissues, particularly the mammary gland. Estradiol classically binds to Estrogen Receptor (ERα), which is a member of the nuclear receptor superfamily. ER mediates nuclear (transcription) and plasma membrane (signaling) ERα function. Interestingly, the membrane initiated steroid signaling (MISS) required a post translational modification of the receptor: palmitoylation of the human Cys-447 or the murine Cys-451 counterpart. The main objectives of my PhD thesis we

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Hale, Amber N. "ANALYSIS OF THE ROLE OF TWO AUTOPHAGY PATHWAY RELATED GENES, BECN1 AND TSC1, IN MURINE MAMMARY GLAND DEVELOPMENT AND DIFFERENTIATION." UKnowledge, 2014. http://uknowledge.uky.edu/biology_etds/18.

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The mammary gland is a dynamic organ that undergoes the majority of its development in the postnatal period in four stages; mature virgin, pregnancy, lactation, and involution. Every stage relies on tightly regulated cellular proliferation, programmed cell death, and tissue remodeling mechanisms. Misregulation of autophagy, an intracellular catabolic process to maintain energy stores, has long been associated with mammary tumorigenesis and other pathologies. We hypothesize that appropriate regulation and execution of autophagy are necessary for proper development of the mammary ductal tree and

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Lee, Paula Maria. "Do women who die of early breast cancer experience a burst of mutations during the growth of the mammary gland in puberty?" Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/39381.

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Pellegrini, Pasquale 1983. "RANK signaling, a master regulator of mammary stemness and cancer : characterization of RANK and RANKL pathway stem cell fate, tumorigenesis and metastasis." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/586316.

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RESUME RANK signaling is essential for mammary gland development and progesterone induced tumorigenesis. Here we show that RANK controls mammary stem cell fate; increased RANK signaling results in accumulation of stem and progenitor cells leading to spontaneous tumor formation. RANK signaling interferes with alveolar commitment through depletion of CD61+ alveolar progenitors and regulation of Elf-5/STAT5 pathway. Using pharmacological and genetic approaches we show that RANK signaling promotes tumor initiation, progression and metastasis in spontaneous breast cancer models and expands tumor in

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