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Journal articles on the topic 'Cancer of mammary gland'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Batan, Sonia, Jabunnesa Khanom, Sabarish Ramachandran, et al. "Abstract P3-04-04: The Butyrate Transporter SLC5A8 Selectively Inhibits Breast Tumor Metastasis." Clinical Cancer Research 31, no. 12_Supplement (2025): P3–04–04—P3–04–04. https://doi.org/10.1158/1557-3265.sabcs24-p3-04-04.

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Abstract Introduction: The mammary gland is a dynamic organ that undergoes significant developmental changes during pregnancy, lactation, and involution. The process of involution is a highly orchestrated series of molecular and physical events that can be divided into two distinct phases. (Lund et al., 1996). Accumulation of milk in the alveolar lumen (milk stasis) is required to initiate the first phase during which the secretory cells begin to enter apoptosis. Here we provide genetic and molecular biological evidence to shows that the short-chain fatty acid Butyrate (BTR), a significant com

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2

Mogus, Joshua Philip. "Exposure to the Endocrine Disruptor, Propylparaben, During Pregnancy and Lactation, Alters Typical Parity-Induced Reorganization of the Mouse Mammary Gland." Journal of the Endocrine Society 5, Supplement_1 (2021): A487—A488. http://dx.doi.org/10.1210/jendso/bvab048.997.

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Abstract The mammary gland is a hormone sensitive organ that is susceptible to endocrine disrupting chemicals (EDCs) during several vulnerable periods, including pregnancy and lactation. Mammary gland reorganization during pregnancy and lactation is hormone driven and provides long-term protection against breast cancer risk. It is unknown if EDC exposures during these sensitive windows can alter mammary reorganization to either enhance or offset parity-induced protection against breast cancer. Here, we examined effects of propylparaben (PP), a common preservative used in personal care products

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3

Atashgaran, Vahid, Pallave Dasari, Leigh J. Hodson, Andreas Evdokiou, Simon C. Barry, and Wendy V. Ingman. "Foxp3 heterozygosity does not overtly affect mammary gland development during puberty or the oestrous cycle in mice." Reproduction, Fertility and Development 32, no. 8 (2020): 774. http://dx.doi.org/10.1071/rd19378.

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Female mice heterozygous for a genetic mutation in transcription factor forkhead box p3 (Foxp3) spontaneously develop mammary cancers; however, the underlying mechanism is not well understood. We hypothesised that increased cancer susceptibility is associated with an underlying perturbation in mammary gland development. The role of Foxp3 in mammary ductal morphogenesis was investigated in heterozygous Foxp3Sf/+ and wildtype Foxp3+/+ mice during puberty and at specific stages of the oestrous cycle. No differences in mammary ductal branching morphogenesis, terminal end bud formation or ductal el

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4

Avagliano, Angelica, Giuseppe Fiume, Maria Rosaria Ruocco, et al. "Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination." Cancers 12, no. 6 (2020): 1697. http://dx.doi.org/10.3390/cancers12061697.

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The stromal microenvironment regulates mammary gland development and tumorigenesis. In normal mammary glands, the stromal microenvironment encompasses the ducts and contains fibroblasts, the main regulators of branching morphogenesis. Understanding the way fibroblast signaling pathways regulate mammary gland development may offer insights into the mechanisms of breast cancer (BC) biology. In fact, the unregulated mammary fibroblast signaling pathways, associated with alterations in extracellular matrix (ECM) remodeling and branching morphogenesis, drive breast cancer microenvironment (BCM) rem

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5

GARIFULLOVA, YU V., L. I. MALTSEVA, and M. G. KALINKINA. "Digital mammography in clinical practice of a gynecologist: highlighting the key points." Practical medicine 21, no. 1 (2023): 17–23. http://dx.doi.org/10.32000/2072-1757-2023-1-17-23.

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High density of the mammary gland, determined with the digital mammography method, is an independent risk factor for mammary gland cancer (MGC). Prescription of combined oral contraceptives, menopausal hormone therapy drugs, intrauterine system with levonorgestrel, and ovulation induction may lead to an increase of mammary gland density (MGD). The latest research showed that the insulin-like growth factor is also a risk factor for mammary gland density. In the Republic of Tatarstan, out of 265,217 examined women, a high mammary gland density was diagnosed in 7%, including in patients older tha

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6

Mustafi, Devkumar, Abby Leinroth, Xiaobing Fan, et al. "Magnetic Resonance Angiography Shows Increased Arterial Blood Supply Associated with Murine Mammary Cancer." International Journal of Biomedical Imaging 2019 (January 17, 2019): 1–6. http://dx.doi.org/10.1155/2019/5987425.

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Breast cancer is a major cause of morbidity and mortality in Western women. Tumor neoangiogenesis, the formation of new blood vessels from pre-existing ones, may be used as a prognostic marker for cancer progression. Clinical practice uses dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to detect cancers based on increased blood flow and capillary permeability. However, DCE-MRI requires repeated injections of contrast media. Therefore we explored the use of noninvasive time-of-flight (TOF) MR angiography for serial studies of mouse mammary glands to measure the number and size o

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Ma, Zhiyuan, Dumin Yuan, Xiaoming Cheng, Biguang Tuo, Xuemei Liu, and Taolang Li. "Function of ion transporters in maintaining acid-base homeostasis of the mammary gland and the pathophysiological role in breast cancer." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 318, no. 1 (2020): R98—R111. http://dx.doi.org/10.1152/ajpregu.00202.2019.

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The incidence of breast cancer is increasing year by year, and the pathogenesis is still unclear. Studies have shown that the high metabolism of solid tumors leads to an increase in hypoxia, glycolysis, production of lactic acid and carbonic acid, and extracellular acidification; a harsh microenvironment; and ultimately to tumor cell death. Approximately 50% of locally advanced breast cancers exhibit hypoxia and/or local hypoxia, and acid-base regulatory proteins play an important role in regulating milk secretion and maintaining mammary gland physiological function. Therefore, ion transporter

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8

Wu, Diana, Lilian U. Thompson, and Elena M. Comelli. "MicroRNAs: A Link between Mammary Gland Development and Breast Cancer." International Journal of Molecular Sciences 23, no. 24 (2022): 15978. http://dx.doi.org/10.3390/ijms232415978.

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Breast cancer is among the most common cancers in women, second to skin cancer. Mammary gland development can influence breast cancer development in later life. Processes such as proliferation, invasion, and migration during mammary gland development can often mirror processes found in breast cancer. MicroRNAs (miRNAs), small, non-coding RNAs, can repress post-transcriptional RNA expression and can regulate up to 80% of all genes. Expression of miRNAs play a key role in mammary gland development, and aberrant expression can initiate or promote breast cancer. Here, we review the role of miRNAs

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9

Anderson, Breanne M., Mira B. MacLennan, Lyn M. Hillyer, and David W. L. Ma. "Lifelong exposure to n-3 PUFA affects pubertal mammary gland development." Applied Physiology, Nutrition, and Metabolism 39, no. 6 (2014): 699–706. http://dx.doi.org/10.1139/apnm-2013-0365.

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There is growing evidence that early developmental periods may importantly influence future breast cancer risk. Also, there is great interest in the role of dietary fat in breast cancer risk, but the role of dietary fat during pubertal mammary gland development remains poorly understood. This study investigated the effect of n-3 polyunsaturated fatty acids (PUFA) using complementary dietary and genetic approaches to examine the effect of lifelong exposure of n-3 PUFA or n-6 PUFA (control) on mammary gland development and fatty acid composition. n-3 PUFA from both diet and genetics were enriche

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10

Chakraborty, Moumita, and Michal Hershfinkel. "Zinc Signaling in the Mammary Gland: For Better and for Worse." Biomedicines 9, no. 9 (2021): 1204. http://dx.doi.org/10.3390/biomedicines9091204.

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Zinc (Zn2+) plays an essential role in epithelial physiology. Among its many effects, most prominent is its action to accelerate cell proliferation, thereby modulating wound healing. It also mediates affects in the gastrointestinal system, in the testes, and in secretory organs, including the pancreas, salivary, and prostate glands. On the cellular level, Zn2+ is involved in protein folding, DNA, and RNA synthesis, and in the function of numerous enzymes. In the mammary gland, Zn2+ accumulation in maternal milk is essential for supporting infant growth during the neonatal period. Importantly,

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11

Werner, Lauryn R., Katelin A. Gibson, Merit L. Goodman, et al. "Abstract P4-04-07: Progesterone promotes immunomodulation and tumor development in the murine mammary gland." Cancer Research 82, no. 4_Supplement (2022): P4–04–07—P4–04–07. http://dx.doi.org/10.1158/1538-7445.sabcs21-p4-04-07.

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Abstract Clinical studies have linked usage of progestins (synthetic progesterone) to breast cancer risk. However, little is understood regarding the role of native progesterone (P4), signaling through the progesterone receptor (PR), in breast tumor formation. Recently, we reported a link between PR and immune signaling pathways, showing that P4/PR can repress type I interferon signaling pathways. Given these findings, we sought to investigate whether P4/PR drive immunomodulation in the mammary gland and promote tumor formation. To determine the effect of P4 on immune cell populations in the m

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12

Kruk, O. Yu. "Clinic-anamnestic factors of the risk of hyperplastic diseases an endometrium, mammary glands and their combination at women of perimenopause age." HEALTH OF WOMAN, no. 6(142) (July 29, 2019): 71–73. http://dx.doi.org/10.15574/hw.2019.142.71.

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The objective: to improve well-timed diagnostics of hyperplastic diseases the endometrium and mammary glands at women of perimenopause age on the basis of studying of the main clinical risk factors. Materials and methods. Were surveyed 145 patients of perimenopause age, 15 from which (group of control) the women who didn’t have hyperplastic diseases of organs of genesial system (made of the contingent gynecological and mammology healthy). Results. Clinical-anamnestic risk factors of the isolated hyperplastic process an endometrium are: early menarche, long and plentiful menses, inflammatory di

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13

Miller, James L., Alexandra Reddy, Rebecca M. Harman, and Gerlinde R. Van de Walle. "A xenotransplantation mouse model to study physiology of the mammary gland from large mammals." PLOS ONE 19, no. 2 (2024): e0298390. http://dx.doi.org/10.1371/journal.pone.0298390.

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Although highly conserved in structure and function, many (patho)physiological processes of the mammary gland vary drastically between mammals, with mechanisms regulating these differences not well understood. Large mammals display variable lactation strategies and mammary cancer incidence, however, research into these variations is often limited to in vitro analysis due to logistical limitations. Validating a model with functional mammary xenografts from cryopreserved tissue fragments would allow for in vivo comparative analysis of mammary glands from large and/or rare mammals and would impro

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14

Hama, Yukihiro. "Quantitative evaluation of radiation-induced metabolic changes in the ipsilateral breast by FDG-PET/CT." Imaging 14, no. 2 (2022): 99–103. http://dx.doi.org/10.1556/1647.2022.00090.

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AbstractBackground and aimThere are no reports of quantitative evaluation of metabolic changes in the mammary gland after radiation therapy. The purpose of this study was to investigate metabolic changes in the ipsilateral mammary gland after radiation therapy and to evaluate the late radiation effects.Patients and methodsMetabolic changes of the ipsilateral and contralateral mammary glands were retrospectively evaluated by F-18 fluorodeoxyglucose (FDG) PET/CT after whole breast irradiation following lumpectomy in five breast cancer patients. The maximum standardized uptake values (SUVmax) of

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15

Werner, Lauryn Rose, Katelin A. Gibson, Merit L. Goodman, et al. "Abstract 1351: Lauryn Werner." Cancer Research 82, no. 12_Supplement (2022): 1351. http://dx.doi.org/10.1158/1538-7445.am2022-1351.

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Abstract Clinical studies have linked usage of progestins (synthetic progesterone) to breast cancer risk. However, little is understood regarding the role of native progesterone (P4), signaling through the progesterone receptor (PR), in breast tumor formation. Recently, we reported a link between PR and immune signaling pathways, showing that P4/PR can repress type I interferon signaling pathways. Given these findings, we sought to investigate whether P4/PR drive immunomodulation in the mammary gland and promote tumor formation. To determine the effect of P4 on immune cell populations in the m

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16

Werner, Lauryn R., Katelin A. Gibson, Merit L. Goodman, et al. "Progesterone promotes immunomodulation and tumor development in the murine mammary gland." Journal for ImmunoTherapy of Cancer 9, no. 5 (2021): e001710. http://dx.doi.org/10.1136/jitc-2020-001710.

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BackgroundClinical studies have linked usage of progestins (synthetic progesterone [P4]) to breast cancer risk. However, little is understood regarding the role of native P4, signaling through the progesterone receptor (PR), in breast tumor formation. Recently, we reported a link between PR and immune signaling pathways, showing that P4/PR can repress type I interferon signaling pathways. Given these findings, we sought to investigate whether P4/PR drive immunomodulation in the mammary gland and promote tumor formation.MethodsTo determine the effect of P4 on immune cell populations in the muri

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17

Ma, Gui, Ang Gao, Mingshan Hu, Ngai Ting Chan, Yidan Wang, and Wei Xu. "Abstract 4312: CTR9 controls the mammary luminal lineage and susceptibility to carcinogen/hormone-induced breast tumors." Cancer Research 85, no. 8_Supplement_1 (2025): 4312. https://doi.org/10.1158/1538-7445.am2025-4312.

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CTR9 encodes a key component of the human RNA polymerase II (RNAPII)-associated factor complex (hPAFc). CTR9 loss-of-function variants are predisposed to rare myeloid malignancies and Wilms tumors. Although CTR9 promotes the growth of estrogen receptor (ER)-positive breast cancer cells and controls the expression of 90% of ER-target genes, the roles of CTR9 in mammary gland development and breast cancer etiology in vivo remain unknown. About 0.1 % of breast cancer patients were found to harbor loss of function CTR9 mutations based on TCGA data. Analyzing normal mouse mammary gland scRNA-seq da

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18

Eivani, D., and P. Mortazavi. "The relationship between basal and luminal cytokeratins with histopathologic characteristics of canine mammary gland cancer." Polish Journal of Veterinary Sciences 19, no. 2 (2016): 261–69. http://dx.doi.org/10.1515/pjvs-2016-0033.

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Abstract Neoplasia occurs mostly in mammary glands in female dogs and mammary gland cancer is one of the causes of death in these animals cytokeratins are one of the most important of tumor markers for identification of tumor prognosis. In this study, 120 canine malignant tumor samples of mammary glands were studied. From each sample, a section was taken for hematoxylin-eosin staining and two sections for immunohistochemical staining of markers CK5/6 and CK7. Histopathology slides was evaluated by light microscope. The results show that the presence of markers CK7 and CK5/6 had no significant

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19

Järvensivu, Päivi, Taija Heinosalo, Janne Hakkarainen, Pauliina Kronqvist, Niina Saarinen, and Matti Poutanen. "HSD17B1 expression induces inflammation-aided rupture of mammary gland myoepithelium." Endocrine-Related Cancer 25, no. 4 (2018): 393–406. http://dx.doi.org/10.1530/erc-17-0476.

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Hydroxysteroid (17-beta) dehydrogenase type 1 (HSD17B1) converts low-active estrogen estrone to highly active estradiol. Estradiol is necessary for normal postpubertal mammary gland development; however, elevated estradiol levels increase mammary tumorigenesis. To investigate the significance of the human HSD17B1 enzyme in the mammary gland, transgenic mice universally overexpressing human HSD17B1 were used (HSD17B1TG mice). Mammary glands obtained from HSD17B1TG females at different ages were investigated for morphology and histology, and HSD17B1 activity and estrogen receptor activation in m

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20

Breindel, Jerrica, Kayla M. Gross, and Charlotte Kuperwasser. "Abstract 54: Regulation of luminal epithelial cell identity in the pre-tumorigenic mammary gland." Cancer Research 83, no. 7_Supplement (2023): 54. http://dx.doi.org/10.1158/1538-7445.am2023-54.

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Abstract The transcription factor MYC is frequently altered in a large portion of human breast cancers; the gene is amplified in ~15% of breast cancers and overexpressed in another 30-50%. Mouse mammary tumor models driven by overexpression of MYC, such as MMTV-Myc, also exhibit a rapid onset and high frequency of mammary tumors indicating that MYC overexpression plays an important role in driving breast carcinogenesis. However, the role of MYC in breast cancer initiation and subtype determination is not well understood. In the normal mammary gland, MYC is a critical regulator of and is essent

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Wang, Wei, Priyanka S. Rana, Akram Alkrekshi та ін. "Targeted Deletion of Kindlin-2 in Mouse Mammary Glands Inhibits Tumor Growth, Invasion, and Metastasis Downstream of a TGF-β/EGF Oncogenic Signaling Pathway". Cancers 14, № 3 (2022): 639. http://dx.doi.org/10.3390/cancers14030639.

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Breast cancer (BC) is one of the leading causes of cancer-related deaths due in part to its invasive and metastatic properties. Kindlin-2 (FERMT2) is associated with the pathogenesis of several cancers. Although the role of Kindlin-2 in regulating the invasion-metastasis cascade in BC is widely documented, its function in BC initiation and progression remains to be fully elucidated. Accordingly, we generated a floxed mouse strain by targeting the Fermt2 (K2lox/lox) locus, followed by tissue-specific deletion of Kindlin-2 in the myoepithelial compartment of the mammary glands by crossing the K2

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Werner, Lauryn R., Dominika E. Helm, Julio Tinoco, et al. "Abstract P2-20-11: Progesterone impacts the growth and immune cell infiltration of murine mammary gland tumors." Cancer Research 83, no. 5_Supplement (2023): P2–20–11—P2–20–11. http://dx.doi.org/10.1158/1538-7445.sabcs22-p2-20-11.

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Abstract Clinical studies have linked usage of progestins (synthetic progesterone) to breast cancer risk. However, little is understood regarding the role of native progesterone (P4), signaling through the progesterone receptor (PR), in breast tumor formation. Recently, we demonstrated that P4 treatment or PR overexpression can drive changes in immune cell populations in the murine mammary gland and that PR overexpression leads to increased development of mammary gland tumors in mice. Given these findings, we sought to investigate whether P4 impacts tumor growth and immune cell infiltration of

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23

CHOUDHARY, RATAN KUMAR, DEVENDRA PATHAK, SHANTI CHOUDHARY, and RAMNEEK VERMA. "Immunolocalization of estrogen alpha and progesterone beta receptors in goat mammary gland." Indian Journal of Animal Sciences 88, no. 4 (2018): 420–27. http://dx.doi.org/10.56093/ijans.v88i4.78803.

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Steroid receptors particularly estrogen receptor alpha and progesterone receptor beta are essential for mammary gland development. Objective of this study was to explore transcript and protein expression profile of steroid receptors in goat mammary glands. A varied expression of ER-alpha and PR-B was observed during lactation, nonlactating/ dry, mastitic and mammary pre-cancer/cancer in goats. During lactation, immunopositivity of ER-alpha was observed only in the nuclei of mammary epithelial cells (MEC) and stromal cells. However, in non-lactating stage, ER-alpha immunopositivity was observed

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Valencakova, Alexandra, Beata Kiselova-Bilekova, Maria Figurova, Slavomir Hornak, and Lubica Hornakova. "Tumor Markers in Dogs with Mammary Gland Tumors." Acta Veterinaria 73, no. 4 (2023): 473–85. http://dx.doi.org/10.2478/acve-2023-0036.

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Abstract The aim of this study was to determine and compare values of carcinoembryonic antigen (CEA) and cancer antigen (CA 15-3) in 50 bitches with mammary tumors and 150 clinically healthy dogs. A modified procedure was used to determine the CEA and CA 15-3 markers with the human kits using the radioimmunoassay method (RIA). Samples collected from extirpated tumors of mammary glands were histologically processed and classified as per WHO guidelines. The mean values of the carcinoembryonic antigen markers ± SD were as follows: control group 0.89 ± 0.79, group with mammary gland tumor 1.53 ± 1

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Cataldo, Alessandra, Douglas G. Cheung, John P. Hagan, et al. "Genetic Loss of miR-205 Causes Increased Mammary Gland Development." Non-Coding RNA 10, no. 1 (2023): 4. http://dx.doi.org/10.3390/ncrna10010004.

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MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205−/− female mice at different ages (1.5 and 5.5 mon

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Si, Hongjiang, Jeffrey Rosen, Chad Creighton, and Kevin Roarty. "Abstract B012: Wnt/Ror2 signaling regulates myoepithelial cell fate and luminal cell proliferation during mammary development." Cancer Research 84, no. 3_Supplement_1 (2024): B012. http://dx.doi.org/10.1158/1538-7445.advbc23-b012.

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Abstract Background: The mammary gland exhibits extensive proliferative and differentiation potential throughout development. Wnt signaling has been recognized as a crucial player in multiple stages of mammary gland development, including mammary placode specification, gland branching morphogenesis, stem cell maintenance, and alveolar development. In our laboratory, prior research has revealed the importance of the β-catenin-independent noncanonical Wnt receptor, Ror2, in branching morphogenesis, cell differentiation, and actin-cytoskeletal dynamics within the mammary epithelium. However, the

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Ormiston, Kate, Neelam Shinde, Gautam Sarathy, et al. "Abstract P1-03-06: Abrupt Involution Leads to Long-Term Mitochondrial Dysfunction and Metabolic Shift – Increasing Risk of Breast Cancer." Clinical Cancer Research 31, no. 12_Supplement (2025): P1–03–06—P1–03–06. https://doi.org/10.1158/1557-3265.sabcs24-p1-03-06.

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Abstract Epidemiological data links higher parity and lack of breastfeeding with increased risk of breast cancer, specifically triple negative breast cancer (TNBC). TNBC is the aggressive hormone receptor and HER2 negative subtype associated with higher mortality rate1. Following pregnancy and lactation, breast remodels to near pre-pregnancy stage through apoptotic cell death and adipocyte repopulation process2. Long-term breastfeeding and gradual weaning of an infant leads to gradual involution (GI) of the breast, while lack of or abrupt discontinuation of breastfeeding after birth leads to a

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Kultaev, A., and I. Zakiryarov. "S-DETECT FUNCTION AS THE LATEST METHOD OF ULTRASOUND EXAMINATION OF MAMMARY GLAND FORMATIONS: COMPARATIVE CHARACTERISTICS." Oncologia i radiologia Kazakhstana 66, no. 4 (2022): 24–32. http://dx.doi.org/10.52532/2663-4864-2022-4-66-24-32.

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Relevance: Worldwide, mammary gland formations remain a public health dilemma. Breast cancer (BC) is one of the leading causes of cancer mortality. Breast cancer ranked 3rd with 8.7-8.1% in the structure of malignant disease mortality in Kazakhstan in 2018-2019. Female breast cancer is the most common cancer. Over 2.2 million cases of breast cancer were registered in 2020, according to the WHO. Worldwide, breast cancer ranks fifth among the causes of mortality (685,000 deaths per year). On average, about 3,000 breast cancer cases are detected yearly in the Republic of Kazakhstan, a

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Mazumdar, Abhijit, Jamal Hill, William Tahaney, et al. "Abstract 715: Targeting the mTOR pathway for the prevention of er-negative breast cancer." Cancer Research 82, no. 12_Supplement (2022): 715. http://dx.doi.org/10.1158/1538-7445.am2022-715.

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Abstract Background: Triple-Negative breast cancer (TNBC) is an aggressive cancer that lacks expression of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. These cancers have a poor prognosis and are treated predominantly with chemotherapy. Therefore, we are working to find preventive therapies for these potentially lethal cancers. Dysregulation of PI3K-mTOR pathway is commonly associated with TNBC and other ER-negative breast cancers. We hypothesized that targeting mTOR may prevent development of ER-negative breast cancers and in this study tested wh

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Suarez-Cabrera, Cristian, Isabel Ojeda-Perez, Raquel Sanchez-Baltasar, et al. "ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland." Cancers 13, no. 21 (2021): 5588. http://dx.doi.org/10.3390/cancers13215588.

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ERAS is a relatively uncharacterized gene of the Ras superfamily. It is expressed in ES cells and in the first stages of embryonic development; later on, it is silenced in the majority of cell types and tissues. Although there are several reports showing ERAS expression in tumoral cell lines and human tumor samples, it is unknown if ERAS deregulated expression is enough to drive tumor development. In this report, we have generated transgenic mice expressing ERAS in myoepithelial basal cells of the mammary gland and in basal cells of stratified epithelia. In spite of the low level of ERAS expre

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McGee, Sharon F., Fiona Lanigan, Emer Gilligan, and Bernd Groner. "Mammary gland biology and breast cancer." EMBO reports 7, no. 11 (2006): 1084–88. http://dx.doi.org/10.1038/sj.embor.7400839.

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Jayraj, Aarthi S., and Seema Singhal. "Mammary gland metastasis of ovarian cancer." International Journal of Gynecologic Cancer 34, no. 10 (2024): 1656. http://dx.doi.org/10.1136/ijgc-2024-005436.

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Johnstone, Megan, Ashley Leck, Taylor Lange, and Lisa Privette Vinnedge. "Abstract A084: DEK overexpression in the murine mammary gland promotes epithelial hyperplasia." Cancer Research 84, no. 3_Supplement_1 (2024): A084. http://dx.doi.org/10.1158/1538-7445.advbc23-a084.

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Abstract Introduction: Breast cancer (BC) remains a leading cause of cancer-associated mortality for women in the USA, which makes it critically important to identify and study molecular drivers of pathogenesis. We have previously identified the chromatin modifying DEK protein to have oncogenic properties. DEK is a histone H3 chaperone that is over-expressed in over 60% of breast cancers, particularly triple negative breast cancers, and is associated with poor survival. To date, all studies regarding the role of DEK in BC have manipulated DEK expression in cultured immortalized MCF10A human ma

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Dickson, Clive, Anna Creer, and Vera Fantl. "Mammary gland oncogenes as indicators of pathways important in mammary gland development." Oncogene 19, no. 8 (2000): 1097–101. http://dx.doi.org/10.1038/sj.onc.1203267.

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35

Wicker, Madison, and Kay-Uwe Wagner. "Cellular Plasticity in Mammary Gland Development and Breast Cancer." Cancers 15, no. 23 (2023): 5605. http://dx.doi.org/10.3390/cancers15235605.

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Cellular plasticity is a phenomenon where cells adopt different identities during development and tissue homeostasis as a response to physiological and pathological conditions. This review provides a general introduction to processes by which cells change their identity as well as the current definition of cellular plasticity in the field of mammary gland biology. Following a synopsis of the evolving model of the hierarchical development of mammary epithelial cell lineages, we discuss changes in cell identity during normal mammary gland development with particular emphasis on the effect of the

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Kuorelahti, Aino, Susana Rulli, Ilpo Huhtaniemi та Matti Poutanen. "Human Chorionic Gonadotropin (hCG) Up-Regulates wnt5b and wnt7b in the Mammary Gland, and hCGβ Transgenic Female Mice Present with Mammary Gland Tumors Exhibiting Characteristics of the Wnt/β-Catenin Pathway Activation". Endocrinology 148, № 8 (2007): 3694–703. http://dx.doi.org/10.1210/en.2007-0249.

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Transgenic (TG) mice expressing human chorionic gonadotropin (hCG) β-subunit under the ubiquitin C promoter, presenting with a moderately elevated level of LH/hCG bioactivity develop multiple neoplasms secondary to the endocrine abnormalities, including mammary gland tumors after the age of 9 months. The increased levels of circulating estradiol, progesterone, and prolactin of the TG females after puberty boost the lobuloalveolar development in the mammary gland resulting ultimately in the formation of estrogen and progesterone receptor-negative, malignant tumors. These tumors have a similar h

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Dr., Diksha Singh Dr. Rokade Prashant Prakash Dr. Abhishek Saxena Dr. Mukul Gabhane Gajanan. "The Hidden Danger: Canine Mammary Tumour." Veterinary Today 4, no. 5 (2025): 760–63. https://doi.org/10.5281/zenodo.15479062.

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The most common neoplasia in female dogs is a mammary tumour, which typically manifests between the ages of 9 and 11. The posterior mammary glands are more commonly affected than the anterior glands, and they might manifest as a single or multiple nodules. Dogs can develop benign as well as malignant tumours; based on histological criteria, around half of the tumours are malignant. A broad spectrum of pathogenic characteristics and clinical signs can be seen in mammary gland tumours. A variety of hormones and growth factors are important in the formation of this tumour, but research is still o

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Tavera-Mendoza, Luz E., and Myles Brown. "A less invasive method for orthotopic injection of breast cancer cells into the mouse mammary gland." Laboratory Animals 51, no. 1 (2016): 85–88. http://dx.doi.org/10.1177/0023677216640706.

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Breast cancer is the most common type of cancer diagnosed in women, and the second most common cause of cancer-related deaths in women in North America. The use of laboratory mice in research is an essential tool for the study of breast cancer biology and for pre-clinical therapeutic development. While subcutaneous flank injections of cancer cells are widely used for studying breast cancer biology and for exploring novel therapies, orthotopic xenografting of tumors into the mouse mammary gland allow for the study of breast cancers in a biologically relevant microenvironment. In this study we r

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Johnstone, Megan E., Ashley L. Leck, Taylor E. Lange, et al. "DEK promotes mammary hyperplasia and is associated with H3K27me3 epigenetic modifications." Life Science Alliance 8, no. 9 (2025): e202503230. https://doi.org/10.26508/lsa.202503230.

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The DEK chromatin remodeling protein has oncogenic functions in breast cancers, but its functional role in normal mammary gland epithelium has remained unexplored. We developed two novel genetically engineered mouse models to study the role of Dek in normal mammary gland biology in vivo. Mammary gland-specific Dek transgenic mice developed hyperplasia and had a transcriptional profile that revealed increased expression of cell cycle, mammary stem/progenitor, and lactation-associated genes. Conversely, Dek knockout mice exhibited mammary gland functional defects resulting in dramatically reduce

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Gardner, H. P., G. K. Belka, G. B. Wertheim, et al. "Developmental role of the SNF1-related kinase Hunk in pregnancy-induced changes in the mammary gland." Development 127, no. 20 (2000): 4493–509. http://dx.doi.org/10.1242/dev.127.20.4493.

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The steroid hormones 17 beta-estradiol and progesterone play a central role in the pathogenesis of breast cancer and regulate key phases of mammary gland development. This suggests that developmental regulatory molecules whose activity is influenced by ovarian hormones may also contribute to mammary carcinogenesis. In a screen designed to identify protein kinases expressed in the mammary gland, we previously identified a novel SNF1-related serine/threonine kinase, Hunk (hormonally upregulated Neu-associated kinase). During postnatal mammary development, Hunk mRNA expression is restricted to a

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He, Zongsheng, Abdel-Majid Khatib, and John W. M. Creemers. "Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer." Cancers 12, no. 9 (2020): 2686. http://dx.doi.org/10.3390/cancers12092686.

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In triple negative breast cancer (TNBC) cell lines, the proprotein convertase Furin cleaves and then activates several protein precursors involved in oncogenesis. However, the in vivo role of Furin in the mammary gland and how mammary gland-specific Furin knockout specifically influences tumor initiation and progression of TNBC is unknown. Here, we report that Furin is frequently overexpressed in TNBC tumors and this correlates with poor prognosis in patients with TNBC tumors. In a whey acidic protein (WAP)-induced mammary epithelial cell-specific Furin knockout mouse model, mice show normal m

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Parmar, Hema, and Gerald R. Cunha. "Epithelial–stromal interactions in the mouse and human mammary gland in vivo." Endocrine-Related Cancer 11, no. 3 (2004): 437–58. http://dx.doi.org/10.1677/erc.1.00659.

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This review deals with the development and hormonal responses of mouse and human mammary glands. A major focus of the review is the role of mesenchymal–epithelial interactions in embryonic mammary development and the role of stromal–epithelial interactions in mammary gland biology. Finally, we present a new model for studying growth, differentiation and hormonal response in human breast epithelium grown in vivo in nude mouse hosts. This new model involves the construction of tissue recombinants composed of human or mouse mammary fibroblasts plus human breast epithelium in polymerized collagen

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Andres, Anne-Catherine, and Valentin Djonov. "The Mammary Gland Vasculature Revisited." Journal of Mammary Gland Biology and Neoplasia 15, no. 3 (2010): 319–28. http://dx.doi.org/10.1007/s10911-010-9186-9.

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Fidianingsih, Ika, Teguh Aryandono, Sitarina Widyarini, and Sri Herwiyanti. "Profile of Histopathological Type and Molecular Subtypes of Mammary Cancer of DMBA-induced Rat and its Relevancy to Human Breast Cancer." Open Access Macedonian Journal of Medical Sciences 10, A (2022): 71–78. http://dx.doi.org/10.3889/oamjms.2022.7975.

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BACKGROUND: Animal models with mammary cancer that closely mimic human breast cancer for treatment development purposes are still required. Induction of 7,12-dimethylbenzanthracene (DMBA) to rats shows the histopathological features and mammary cancer characterization similar to humans. Examinations of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki67 expressions are crucial in deciding the treatment and prognosis of breast cancer. AIM: This research aimed to view histopathology images of mammary glands and expressions of ER, PR, Ki67

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Baumrucker, Camille C., Ganesan Ramamoorthi, William Dominguez-Viqueira, and Brian J. Czerniecki. "Abstract 6150: Intramammary gland activation of invariant natural killer T cells with anti-tumor CD4Th1 cells prevents the development of invasive mammary carcinoma." Cancer Research 85, no. 8_Supplement_1 (2025): 6150. https://doi.org/10.1158/1538-7445.am2025-6150.

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Breast cancer (BC) remains one of the most prevalent cancers in the world thus prompting efforts in risk reduction and prevention. Current strategies for prevention are limited to hormone therapy or prophylactic surgery, which are not without complication. Patients with preinvasive malignant lesions of the breast, including ductal carcinoma in situ (DCIS), if left untreated or after surgical resection, have a higher risk of developing invasive BC (IBC). In addition, clinical studies have shown that a subset of DCIS patients who did not progress to invasive disease died from recurrence or dista

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Banks, Briana, Marianna Johnson, Joscelyn Hoffmann, et al. "Abstract 24: The effect of chronic psychological stress during puberty and early adulthood on mammary gland development and mammary cancer risk in adulthood." Cancer Research 82, no. 12_Supplement (2022): 24. http://dx.doi.org/10.1158/1538-7445.am2022-24.

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Abstract Breast cancer is the second most common cancer among women in the United States. Puberty is a well-established sensitive period in women when breast cancer (BC) risk is increased by the physical environment for example exposure to chemical carcinogens, synthetic estrogens, endocrine disrupters, radiation, etc. However, relatively little is known about effects of exposure to chronic psychological stress from the social environment during this time period (puberty and early adulthood). In previous studies using the Sprague-Dawley rat model of spontaneous mammary cancer, chronically heig

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Hipp, Elizabeth, Xiaobing Fan, Sanaz A. Jansen, et al. "T2* relaxation times of intraductal murine mammary cancer, invasive mammary cancer, and normal mammary gland." Medical Physics 39, no. 3 (2012): 1309–13. http://dx.doi.org/10.1118/1.3684950.

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Jung, Nora, Veronique Maguer-Satta, and Boris Guyot. "Early Steps of Mammary Stem Cell Transformation by Exogenous Signals; Effects of Bisphenol Endocrine Disrupting Chemicals and Bone Morphogenetic Proteins." Cancers 11, no. 9 (2019): 1351. http://dx.doi.org/10.3390/cancers11091351.

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Estrogens are major regulators of the mammary gland development, notably during puberty, via estrogen receptor (ER) activation, leading to the proliferation and differentiation of mammary cells. In addition to estrogens, the bone morphogenetic proteins (BMPs) family is involved in breast stem cell/progenitor commitment. However, these two pathways that synergistically contribute to the biology of the normal mammary gland have also been described to initiate and/or promote breast cancer development. In addition to intrinsic events, lifestyle habits and exposure to environmental cues are key ris

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Schedin, Pepper, Jenean O’Brien, Michael Rudolph, Torsten Stein, and Virginia Borges. "Microenvironment of the Involuting Mammary Gland Mediates Mammary Cancer Progression." Journal of Mammary Gland Biology and Neoplasia 12, no. 1 (2007): 71–82. http://dx.doi.org/10.1007/s10911-007-9039-3.

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Barnes, Betsy, Zarina Brune, Matthew Rice, and Carter Somerville. "Abstract P5-15-01: Rediscovering IRF5: A prognostic indicator with novel roles in mammary gland development, ribosome biogenesis, tumor initiation, and metastasis." Cancer Research 83, no. 5_Supplement (2023): P5–15–01—P5–15–01. http://dx.doi.org/10.1158/1538-7445.sabcs22-p5-15-01.

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Abstract Breast cancer is the second leading cause of death for women in the United States. However, only 10% of breast cancers have been linked to inherited genomic mutations. Thus, identifying biomarkers to predict cancer progression and metastasis remains a clear need in the research and medical world. Here, we report a novel role for Interferon Regulatory Factor 5 (IRF5) in mammary gland development, tumorigenesis, and metastasis. Historically, IRF5 has been studied as a transcription factor in the context of genetic risk for autoimmune diseases. However, mining of The Cancer Genome Atlas

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