Journal articles: 'Cardiopathie hypertensive'

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Galinier, M., A. Pathak, V. Fallouh, C. Baixas, L. Schmutz, J. Roncalli, S. Boveda, and J. M. Fauvel. "Intérêt du holter ECG dans la surveillance de la cardiopathie hypertensive." Annales de Cardiologie et d'Angéiologie 51, no. 6 (December 2002): 336–40. http://dx.doi.org/10.1016/s0003-3928(02)00151-8.

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Salami, O. F., K. M. Onuoha, P. K. Uduagbamen, B. A. Olayinka, and O. A. Alade. "Anaesthetic Management of the Elderly with Low Ejection Fraction Undergoing Non-cardiac Surgery." Research Journal of Health Sciences 8, no. 3 (October 9, 2020): 209–13. http://dx.doi.org/10.4314/rejhs.v8i3.7.

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Low ejection fraction in the elderly presenting for anaesthesia could be very challenging to the anaesthetist on account of the heightened risk of perioperative complications. The combined risk of low ejection fraction and poor cardiac reserve may predispose to increase perioperative mortality. Complications in the perioperative period includes acute exacerbation of heart failure which can arise from pump failure or cardiac dyskinesia, and these could be debilitating in the elderly. Therefore, maintaining good systolic function and cardiac rhythm will ensure cardiovascular stability. We present the management of an 89year old man who had hypertensive heart disease with ejection fraction of 40% that successfully had dynamic hip replacement under combined spinal epidural (CSE) anaesthesia. Keywords: neuraxial blockade, ejection fraction, elderly. French title: Prise en charge anesthésique des âgées à faible taux d'éjection subissant une chirurgie non cardiaqueUne faible fraction d'éjection chez les âgées se présentant pour une anesthésie pourrait être très difficile pour l'anesthésiste en raison du risque accru de complications péri opératoires. Le risque combiné de faible fraction d'éjection et de faible réserve cardiaque peut prédisposer à une augmentation de la mortalité péri opératoire. Les complications de la période péri opératoire comprennent une exacerbation aiguë de l'insuffisance cardiaque qui peut résulter d'une défaillance de la pompe ou d'une dyskinésie cardiaque, et celles-ci pourraient être débilitantes chez les personnes âgées. Par conséquent, le maintien d'une bonne fonction systolique et d'un bon rythme cardiaque assurera la stabilité cardiovasculaire. Nous présentons la prise en charge d'un homme de 89 ans qui avait une cardiopathie hypertensive avec une fraction d'éjection de 40% qui a eu avec succès une arthroplastie dynamique de la hanche sous anesthésie épidurale rachidienne combinée (AERC). Mots-clés : Blocage neuraxial, fraction d'éjection, personnes âgées

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A, Álvarez-Aliaga. "Non-hemodynamic factors associated to the risk of developing hypertensive cardiopathy." Journal of Cardiology and Cardiovascular Medicine 2, no. 1 (2017): 068–84. http://dx.doi.org/10.29328/journal.jccm.1001017.

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Swynghedauw, Bernard, and Christophe Baillard. "Biology of hypertensive cardiopathy." Current Opinion in Cardiology 15, no. 4 (July 2000): 247–53. http://dx.doi.org/10.1097/00001573-200007000-00007.

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Beghetti, M. "Hypertension artérielle pulmonaire des cardiopathies congénitales." Revue des Maladies Respiratoires 23, no. 4 (September 2006): 49–59. http://dx.doi.org/10.1016/s0761-8425(06)71797-1.

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M., Moussa, Kolié A., Camara A., Kourouma A., Saley M., and Touré A. "Prevalence Des Maladies Stomatologiques En Milieu Cardiologique Dans Les Hopitaux Nationaux De Niamey." European Scientific Journal, ESJ 17, no. 21 (June 30, 2021): 180. http://dx.doi.org/10.19044/esj.2021.v17n21p180.

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Objectif: Déterminer la prévalence des maladies stomatologiques en milieu cardiologique dans le service de stomatologie de l’Hôpital National de Niamey. Patients et Méthodes: Il s’agissait d’une étude prospective à-propos de 104 cas recensés en 5 mois (1er Novembre 2017 au 31 Mars 2018). Ont été inclus dans l’étude, les patients hospitalisés ou envoyés par le service de cardiologie ayant consenti à l’étude et présentant une (ou des) affection stomatologique. N’ont pas fait partie de l’étude tous les patients ne répondant pas aux critères sus cités. Les variables étudiées étaient le sexe, l’âge, la clinique, l’épidémiologie et la thérapeutique. Résultats: Soixante-dix patients avec une affection stomatologique soit 67,3% ont été adressés par le service de cardiologie et 34 patients avec une affection cardiologique soit 32,7% ont été vus au service service de stomatologie. 62 patients soit 59,6% étaient vus en consultation et 42 patients soit 40,4% étaient hospitalisés. Une prédominance féminine était notée dans 58,7% des cas. La tranche d’âge de 50 et 59 ans était la plus concernée avec un âge moyen de 30,8ans. La carie dentaire était retrouvée dans 59,6% des cas et la cardiopathie hypertensive dans 65,4 %. Le traitement était axé sur le brossage dentaire effectué dans 40,4% des cas, le régime hyposodé dans 90,4% des cas, les IEC dans 50% des cas, les diurétiques dans 35,6% des cas et l’antibiothérapie dans 34,6%. L’évolution sous traitement des deux affections était favorable à plus de 80%. Conclusion: L’étude a permis de dégager la prévalence des maladies stomatologiques et cardiovasculaires à l’Hôpital National de Niamey et l’Hôpital National de Lamordé et d’avoir une perspective thérapeutique adéquate permettant une bonne évolution de l’état de santé des patients. Aim: To determine the prevalence of stomatological diseases in a cardiological environment in the stomatology department of the National Hospital of Niamey. Patients and Methods: This was a prospective study of 104 cases identified in 5 months (November 1, 2017 to March 31, 2018). Included in the study were patients hospitalized or referred by the cardiology department, who consented to the study and presented one or more stomatologic disease. All patients who meet the above criteria were included in the study. The variables studied were sex, age, clinic, epidemiology, and therapy. Results: Seventy patients with a stomatological condition, i.e., 67.3%, were referred by the cardiology service. 34 patients with a cardiological condition or 32.7% of them were seen in the stomatology service. 62 patients or 59.6% were seen in consultation and 42 patients or 40.4% were hospitalized. A female predominance was noted in 58.7% of cases. The 50 and 59 age group was the most affected with an average age of 30.8 years. Dental caries was found in 59.6% of cases and hypertensive heart disease in 65.4%. The treatment focused on tooth brushing performed in 40.4% of cases, a low sodium diet in 90.4% of cases, ACE inhibitors in 50% of cases, diuretics in 35.6% of cases, and antibiotic therapy in 34.6% of cases. The outcome under treatment for both conditions was more than 80% favorable. Conclusion: The study made it possible to identify the prevalence of stomatological and cardiovascular diseases at the National Hospital of Niamey and the National Hospital of Lamordé. It also provided an adequate therapeutic perspective that allows a good evolution of the state of health of the patients.

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de Araújo Bueno Neto, Antenor, Yan Augusto Gomes Silva, Jacqueline Satomi Tho, Camila Gasparotto Fernandes, Felipe Gazza Romão, Beatriz Perez Floriano, and Luciene Maria Martinello Romão. "Retrospective study of the prevalence of heart diseases in dogs." Clínica Veterinária XXII, no. 129 (July 1, 2017): 46–54. http://dx.doi.org/10.46958/rcv.2017.xxii.n.129.p.46-54.

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This work aimed to analyze the frequency of the main cardiopathies in dogs treated in the region of Bauru, SP, Brazil. A population of 466 dogs (285 females and 181 males) referred to a veterinary cardiology center from January 1st, 2014 to July 31st, 2015 was evaluated by echocardiographic examination. Factors such as race, age and sex were considered. Valvular disease was the most prevalent heart condition, followed by pulmonary hypertension. The increase in complementary diagnostic methods in the clinical practice has increased the possibility of diagnosis of cardiopathies in veterinary medicine.

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Bartha, E., I. Solti, L. Kereskai, J. Lantos, E. Plozer, K. Magyar, E. Szabados, et al. "PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats." Cardiovascular Research 83, no. 3 (May 14, 2009): 501–10. http://dx.doi.org/10.1093/cvr/cvp144.

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Di Bello, V., R. Pedrinelli, A. Bertini, D. Giorgi, A. Cioppi, E. Talini, L. Moretti, et al. "CYCLIC VARIATION OF MYOCARDIAL INTEGRATED BACKSCATTER SIGNAL IN HYPERTENSIVE CARDIOPATHY." Journal of Hypertension 18 (June 2000): S70—S71. http://dx.doi.org/10.1097/00004872-200006001-00239.

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Juliano, Guilherme Ribeiro, Laura Sanches Aguiar, Maria Luíza Gonçalves dos Reis Monteiro, Gustavo Branquinho Alberto, Bianca Gonçalves Silva Torquato, Mariana Silva Oliveira, José Eduardo dos Reis Félix, et al. "Morphological and histopathological evaluation of autopsied patients with hypertensive cardiopathy." Annals of Diagnostic Pathology 41 (August 2019): 79–82. http://dx.doi.org/10.1016/j.anndiagpath.2019.04.012.

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Jalini, Shirin, Rajasumi Rajalingam, Rosane Nisenbaum, Angelo Dave Javier, Anna Woo, and Aleksandra Pikula. "Atrial cardiopathy in patients with embolic strokes of unknown source and other stroke etiologies." Neurology 92, no. 4 (December 5, 2018): e288-e294. http://dx.doi.org/10.1212/wnl.0000000000006748.

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ObjectiveTo investigate the prevalence and clinical determinants of atrial cardiopathy in patients with embolic stroke of unknown source (ESUS) and compare with other established stroke etiologies.MethodsIn a cross-sectional study of 846 consecutive patients with ischemic stroke, we compared the prevalence of atrial cardiopathy (defined by p-wave terminal force in V1 >5,000 µV·ms or severe left atrial enlargement) between ESUS patients and patients with large artery atherosclerosis (LAA) and small vessel disease (SVD) strokes. Baseline characteristics were also compared between ESUS and cardioembolic (CE) patients.ResultsOf all, 158 (19%) patients met ESUS diagnostic criteria, while others were classified into LAA (n = 224, 26%), SVD (n = 154, 18%), and CE (n = 310, 37%). The prevalence of atrial cardiopathy was higher in ESUS patients compared to noncardioembolic stroke patients (26.6% vs 12.1% in LAA vs 16.9% in SVD; p = 0.001). ESUS patients were younger, were less hypertensive, and had higher cholesterol and low-density lipoprotein levels, but also had less left ventricular or atrial abnormalities when compared to CE patients.ConclusionThe prevalence of atrial cardiopathy was high in ESUS patients compared with patients with nonembolic strokes. Interestingly, ESUS patients were also clinically different from CE patients. While the presence of atrial cardiopathy may reflect a unique mechanism of thromboembolism in ESUS patients, it is still unclear if they may benefit from anticoagulation, or if the presence of atrial cardiopathy in this population could serve as a risk-stratifying marker for stroke recurrence. Further efforts are necessary to provide better characterization of the ESUS population in order to develop better stroke preventive strategies.

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Ciarambino, Tiziana, Filippina Ciaburri, Venere Delli Paoli, Giuseppe Caruso, Mauro Giordano, and Maria D’Avino. "Arterial Hypertension and Diabetes Mellitus in COVID-19 Patients: What Is Known by Gender Differences?" Journal of Clinical Medicine 10, no. 16 (August 23, 2021): 3740. http://dx.doi.org/10.3390/jcm10163740.

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Background. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected >160 million people around the world. Hypertension (HT), chronic heart disease (CHD), and diabetes mellitus (DM) increase susceptibility to SARS-CoV-2 infection. Aims. We designed this retrospective study to assess the gender differences in hypertensive diabetic SARS-CoV-2 patients. We reported data, by gender differences, on the inflammatory status, on the hospital stays, intensive care unit (ICU) admission, Rx and CT report, and therapy. Methods. We enrolled 1014 patients with confirmed COVID-19 admitted into different Hospitals of Campania from 26 March to 30 June, 2020. All patients were allocated into two groups: diabetic-hypertensive group (DM-HT group) that includes 556 patients affected by diabetes mellitus and arterial hypertension and the non-diabetic- non-hypertensive group (non-DM, non-HT group) comprising 458 patients. The clinical outcomes (i.e., discharges, mortality, length of stay, therapy, and admission to intensive care) were monitored up to June 30, 2020. Results. We described, in the DM-HT group, higher proportion of cardiopathy ischemic (CHD) (47.5% vs. 14.8%, respectively; p < 0.0001) and lung diseases in females compared to male subjects (34.8% vs. 18.5%, respectively; p < 0.0001). In male subjects, we observed higher proportion of kidney diseases (CKD) (11% vs. 0.01%, respectively; p < 0.0001), a higher hospital stay compared to female subjects (22 days vs. 17 days, respectively, p < 0.0001), a higher admission in ICU (66.9% vs. 12.8%, respectively, p < 0.0001), and higher death rate (17.3% vs. 10.7%, respectively, p < 0.0001). Conclusion. These data confirm that male subjects, compared to female subjects, have a higher hospital stay, a higher admission to ICU, and higher death rate.

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Álvarez Aliaga, Alexis, Julio César González-Aguilera, Liliana del Rosario Maceo-Gómez, and Alexis Suárez-Quesada. "Predictive model for the development of hypertensive cardiopathy: A prospective cohort study." Medwave 17, no. 04 (May 15, 2017): e6954-e6954. http://dx.doi.org/10.5867/medwave.2017.04.6954.

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Akai, Kenju, Tetsuya Hirotomi, Aoi Mishima, Keiko Aoki, Tsunetaka Kijima, and Toru Nabika. "Continuous Efforts Leads to a Value for Hypertensive Patients: Development of a Casual Smart Na/K Meter and Smart Na/K Application Linked by NFC to Android." International Journal of Automation Technology 14, no. 5 (September 5, 2020): 791–99. http://dx.doi.org/10.20965/ijat.2020.p0791.

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This study develops a casual smart Na/K meter to measure the sodium and potassium in urine for hypertensive patients. To prevent hypertension from leading to cardiopathies, it is useful to reduce salt intake. The Omron Healthcare Co., Ltd. lunched the prototype, a casual Na/K meter to measure the salt intake from a diet. Nevertheless, it lacks the function to make the patients grasp the historical data. This study improves that meter by adding the NFC and developing the software application linked to Android smartphones and smart watches. Smartphones can store the data and display the historical data. Smart watches make up a part of their daily lives by alerts and messages. The concept of this study provides a continuous value for hypertensive patients. That value is similar to the learning value but it exists beyond the learning effect. For the learning value, after the subjects learn something and obtain the skills, ability, and knowledge, the value is fixed and completed. On the other hand, for the continuous value, the learning value is also included and the subjects receive the learning value; however, they need to continue that behavior until death. If they stop reducing salt intake, they return to hypertension. If they get satisfied with obtaining the learning value and stop their actions, they never receive the continuous value that exists beyond the learning value. The continuous value is brewed in the transtheoretical model of health behavior change. Throughout these stages, to encourage their behavioral change and obtain the continuous value, this study employs Fogg’s theory applied to developing the communication devices. The application stocks the historical data and displays it on the smartphones. The smart watches classify alerts into five colored displays from green (good) to red (bad). It can be helpful for the patients to make the reduction of salt intake as their dietary habit. In the future, the application needs to be improved for making patients adapt with their diets and motivations.

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Balbueno, Melina Castilho de Souza, Kleber da Cunha Peixoto, and Cidéli de Paula Coelho. "Evaluation of the Efficacy of Crataegus oxyacantha in Dogs with Early-Stage Heart Failure." Homeopathy 109, no. 04 (July 17, 2020): 224–29. http://dx.doi.org/10.1055/s-0040-1710021.

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Abstract Background Myxomatous mitral valve disease (MMVD) is the most common cardiopathy in middle-aged dogs. When the dog is asymptomatic and has an enlarged left atrium, treatment is beneficial; however, some allopathic drugs are very costly and may produce side effects. To extend the duration of this asymptomatic phase, complementary therapies such as herbal medicine and homeopathy are available. Although herbal therapy with extract of Crataegus oxyacantha is beneficial, there is a risk of adverse reactions—unlike with homeopathy, where the risk is minimized with the administration of ultra-diluted doses. Objective This study evaluated the efficacy of Crataegus oxyacantha, as mother tincture (MT) and in 6 cH homeopathic formulation, in treating the initial phase of heart failure due to MMVD in a veterinary clinic setting. Methods A total of 30 dogs with MMVD, 7 years or older and weighing up to 10 kg, were randomized into three groups as follows: Crataegus 6 cH, Crataegus MT, and hydroalcoholic solution (placebo). Animals were evaluated through echocardiography parameters, laboratory blood tests, and systolic blood pressure (SBP) measurements at 30, 60, 90, and 120 days after initiation of therapy, for statistical analysis and monitoring of the blinded study. Results Patients who received Crataegus 6 cH showed a reduction in SBP 60 days after treatment, while those receiving Crataegus MT exhibited a reduction 90 days after the therapy was initiated. There was a significant linear regression when evaluating the effect of treatment with Crataegus 6 cH on SBP measurements over the evaluation intervals (linear equation: SBP = 176.57 mm Hg – 0.21x, where x represents days of treatment). There was an increase in both fractional shortening and isovolumetric relaxation time for those patients receiving the homeopathic formulation. Conclusions Therapy with Crataegus was beneficial for hypertensive and cardiopathic dogs with MMVD, extending the duration of the asymptomatic phase. The reduction in SBP occurred more swiftly in the 6 cH group than in the MT-treated dogs.

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Corone, S., and L. Cohen. "Les nouvelles indications de la réadaptation cardiaque : cardiopathies congénitales et hypertension artérielle pulmonaire." Archives des Maladies du Coeur et des Vaisseaux - Pratique 2015, no. 237 (April 2015): 19–22. http://dx.doi.org/10.1016/s1261-694x(15)30032-8.

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Di Bello, V., R. Pedrinelli, A. Bertini, D. Giorgi, A. Cioppi, E. Talini, L. Moretti, M. T. Caputo, G. DellʼOmo, and C. Giusti. "DOPPLER TISSUE IMAGING AND MYOCARDIAL FUNCTION IN HYPERTENSIVE CARDIOPATHY. COMPARISON WITH ATHLETEʼS HEART." Journal of Hypertension 18 (June 2000): S70. http://dx.doi.org/10.1097/00004872-200006001-00237.

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Sokolov, A. A., G. I. Martsinkevich, and A. V. Smorgon. "THE DIAGNOSTIC VALUE OF THE ECHOCARDIOGRAPHIC MYOCARDIAL INDEX OF TEI IN THE ESTIMATION OF DISORDERS OF THE PUMP AND CONTRACTILE FUNCTIONS OF THE LEFT VENTRICLE." Siberian Medical Journal 34, no. 1 (April 23, 2019): 61–68. http://dx.doi.org/10.29001/2073-8552-2018-34-1-61-68.

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Aim. To evaluate the informational and diagnostic significance of the myocardial Tei index.Patients and methods. The study assessed data of echocardiographic studies of 9,256 patients aged 1 month to 60 years, 1,350 healthy individuals, and 7,906 patients with various cardiovascular diseases with abnormal volume-capacitive characteristics of the heart (congenital heart defects, different types of cardiopathy, and hypertensive disease).Results. The cutting points of the normal values of the indicator were established. Data showed that the Tei index did not reflect changes in the pumping function of the left ventricle and did not depend on the contractility of the left ventricle (LV), but it had direct significant correlation with the left ventricular filling pressure, both in normal and pathological conditions. Correlation was more significant in adult patients.Conclusion. Normal values of the Tei index less than 0.5 were observed in more than 95% of practically healthy individuals of any age. The maximum sensitivity and specificity of the myocardial performance index was found in patients with restrictive and dilated cardiopathy and common atrioventricular connection.

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Sokolov, A. A., G. I. Martsinkevich, and A. V. Smorgon. "THE DIAGNOSTIC VALUE OF THE ECHOCARDIOGRAPHIC MYOCARDIAL INDEX OF TEI IN THE ESTIMATION OF DISORDERS OF THE PUMP AND CONTRACTILE FUNCTIONS OF THE LEFT VENTRICLE." Siberian Medical Journal 34, no. 1 (April 23, 2019): 61–68. http://dx.doi.org/10.29001/2073-8552-2019-34-1-61-68.

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Aim. To evaluate the informational and diagnostic significance of the myocardial Tei index.Patients and methods. The study assessed data of echocardiographic studies of 9,256 patients aged 1 month to 60 years, 1,350 healthy individuals, and 7,906 patients with various cardiovascular diseases with abnormal volume-capacitive characteristics of the heart (congenital heart defects, different types of cardiopathy, and hypertensive disease).Results. The cutting points of the normal values of the indicator were established. Data showed that the Tei index did not reflect changes in the pumping function of the left ventricle and did not depend on the contractility of the left ventricle (LV), but it had direct significant correlation with the left ventricular filling pressure, both in normal and pathological conditions. Correlation was more significant in adult patients.Conclusion. Normal values of the Tei index less than 0.5 were observed in more than 95% of practically healthy individuals of any age. The maximum sensitivity and specificity of the myocardial performance index was found in patients with restrictive and dilated cardiopathy and common atrioventricular connection.

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Mogollón, M. V., E. Lage Gallé, R. Hinojosa Pérez, A. Herruzo Avilés, J. M. Sobrino Márquez, N. Romero Rodríguez, and Á. Martínez Martínez. "Prognosis After Heart Transplant in Patients With Pulmonary Hypertension Secondary to Cardiopathy." Transplantation Proceedings 40, no. 9 (November 2008): 3031–33. http://dx.doi.org/10.1016/j.transproceed.2008.09.051.

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Di Bello, Vitantonio, Roberto Pedrinelli, Alessio Bertini, Davide Giorgi, Enrica Talini, Giulia DellʼOmo, and Mario Mariani. "Cyclic variation of the myocardial integrated backscatter signal in hypertensive cardiopathy: a preliminary study." Coronary Artery Disease 12, no. 4 (June 2001): 267–75. http://dx.doi.org/10.1097/00019501-200106000-00002.

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Carpiniello, Bernardo, Federica Pinna, and Raffaella Tuveri. "Delusional Infestation in a Patient with Renal Failure, Metabolic Syndrome, and Chronic Cerebrovascular Disease Treated with Aripiprazole: A Case Report." Case Reports in Medicine 2011 (2011): 1–3. http://dx.doi.org/10.1155/2011/103652.

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Delusional infestation is an aspecific psychiatric condition manifested either as a primary psychotic disorder or a secondary disorder induced by a wide range of very different medical conditions. Both primary and secondary delusional infestations seem to respond to typical and atypical antipsychotics. The latter are considered the first-line treatment although the use of second-generation antipsychotics featuring a higher metabolic, cardiovascular, and renal tolerability is preferable in secondary cases, which often occur in patients with multiple, severe medical conditions. We report a case of a 72-year-old patient affected by delusional infestation associated with severe renal failure, metabolic syndrome, hypertensive cardiopathy, and chronic cerebrovascular disease.

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Gonçalves, Lucas Braz, Helio Amante Miot, Maria Aparecida Custódio Domingues, and Cristiano Claudino Oliveira. "Autopsy Patients With Obesity or Metabolic Syndrome as Basic Cause of Death: Are There Pathological Differences Between These Groups?" Clinical Medicine Insights: Pathology 11 (January 1, 2018): 117955571879157. http://dx.doi.org/10.1177/1179555718791575.

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Background: The objectives of this study were the evaluation of pathological characteristics of patients with obesity or metabolic syndrome (MS) as basic cause of death, associating the autopsy findings with some clinical aspects and the abdominal adipose panicle thickness. Methods: A total of 88 autopsy cases were studied, divided into 2 groups based on the main cause of death: group 1 (n = 15) obesity and group 2 (n = 73) MS. Clinical summaries of autopsy requests, macroscopic findings, and histologic sections were reviewed. Results: The definition of obesity as the basic cause of death is associated with larger thickness of the abdominal adipose panicle, being 8.5 cm ( P = .001) the best measurement, according to the receiver operating characteristic curve. Hypertensive cardiopathy ( P = .001), ischemic cardiopathy ( P = .003), coronary ( P = .008)/systemic ( P = .005) atherosclerosis, and arterial ( P = .014)/arteriolar ( P = .027) nephrosclerosis are associated with the diagnosis of MS. Steatohepatitis is associated with the diagnosis of obesity ( P = .030); however, its association with the thickness of the abdominal adipose panicle is not statistically significant ( P = .211). Conclusions: In the context of an obese patient in autopsy, pathologist may use the information about abdominal adipose panicle associated with heart, kidney, and liver findings, even macroscopic ones, to decide the basic cause death between obesity and MS.

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Di Bello, V. "Cyclic variation of myocardial integrated backscatter signal of the hypertensive cardiopathy. comparison with the athlete's heart." American Journal of Hypertension 13, no. 6 (June 2000): S3—S4. http://dx.doi.org/10.1016/s0895-7061(00)00310-1.

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Martins-Filho, Euclides Dias, José Bezerra Câmara-Neto, Álvaro Antônio Bandeira Ferraz, Melânia Amorim, and Edmundo Machado Ferraz. "Evaluation of risk factors in superobese patients submitted to conventional Fobi-Capella surgery." Arquivos de Gastroenterologia 45, no. 1 (March 2008): 3–10. http://dx.doi.org/10.1590/s0004-28032008000100002.

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BACKGROUND: Obesity is one of the world’s greatest health problems. The Roux-en-Y gastric bypass is the gold standard treatment for severe obesity. Surgery in obese patients has an acceptable level of morbidity and mortality. The superobese patient, a subcategory of severe obese patients with a high surgical risk has not yet been analyzed as a group. METHODS: A retrospective and prospective cohort study was conducted enrolling 135 patients submitted to Roux-en-Y gastric bypass for treatment of severe obesity at the " Hospital das Clínicas" , Federal University of Pernambuco, Recife, PE, Brazil, between November 1997 and September 2003. The independent variables were possible risk factors of adverse outcomes: age, gender, weight, body mass index, diabetes, hypertension, hypercholesterolemia, sleep apnea, cardiopathy/coronariopathy, pneumopathy or any other co-morbidity. The dependent variables were major complications, minor complications and death. RESULTS: Diabetes (RR = 1.6 and CI = 1.02-2.40) and sleep apnea (RR = 1.8 and CI = 1.18-2.64) were associated to minor complications. Cardiopathy/coronariopathy were associated with major complications (RR = 5.42 and CI = 1.22-2.40) and death (RR = 16.25 and CI = 3.00-87.95). BMI >55 kg/m² was associated with minor complications (RR = 1.58 and CI = 1.04-2.40), major complications (RR = 3.17 and CI = 1.03-9.80) and death (P = 0.007). After logistic regression, the body mass index >55 kg/m² remained as a strong risk factor of death (OR = 3.6 and CI = 1.05-12.32). CONCLUSIONS: The body mass index >55 kg/m² was the main risk factor for severe complications and death. Other risk factors affecting the outcome were diabetes, obstructive sleep apnea and cardiopathy/coronariopathy.

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Dossena, Marta, Anna Ferrario, Valentina Lopardo, Elena Ciaglia, and Annibale Alessandro Puca. "New Insights for BPIFB4 in Cardiovascular Therapy." International Journal of Molecular Sciences 21, no. 19 (September 28, 2020): 7163. http://dx.doi.org/10.3390/ijms21197163.

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Aging is the most relevant risk factor for cardiovascular diseases which are the main cause of mortality in industrialized countries. In this context, there is a progressive loss of cardiovascular homeostasis that translates in illness and death. The study of long living individuals (LLIs), which show compression of morbidity toward the end of their life, is a valuable approach to find the key to delay aging and postpone associate cardiovascular events. A contribution to the age-related decline of cardiovascular system (CVS) comes from the immune system; indeed, it is dysfunctional during aging, a process described as immunosenescence and comprises the combination of several processes overpowering both innate and adaptative immune system. We have recently discovered a longevity-associated variant (LAV) in bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4), which is a secreted protein able to enhance endothelial function through endothelial nitric oxide synthase (eNOS) activation and capable to protect from hypertension, atherosclerosis, diabetic cardiopathy, frailty, and inflammaging. Here, we sum up the state of the art of the mechanisms involved in the main pathological processes related to CVD (atherosclerosis, aging, diabetic cardiopathy, and frailty) and shed light on the therapeutic effects of LAV-BPIFB4 in these contexts.

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Álvarez-Aliaga, Alexis, Adonis Frómeta-Guerra, Alexis Suárez-Quesada, David del Llano-Sosa, Joel Berdú-Saumell, and Yasel Alberto Lago-Santiesteban. "Prognostic model of the adaptive changes from hypertensive cardiopathy: from mild diastolic dysfunction to depressed systolic function." Medwave 20, no. 03 (April 28, 2020): e7873-e7873. http://dx.doi.org/10.5867/medwave.2020.03.7873.

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Di Bello, V. "Doppler tissue imaging in the evaluation of myocardial function of the hypertensive cardiopathy, comparison with athlete's heart." American Journal of Hypertension 13, no. 6 (June 2000): S48—S49. http://dx.doi.org/10.1016/s0895-7061(00)00417-9.

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Gammone, Maria Alessandra, and Nicolantonio D’Orazio. "Cocoa Overconsumption and Cardiac Rhythm: Potential Arrhythmogenic Trigger or Beneficial Pleasure?" Current Research in Nutrition and Food Science Journal 9, no. 1 (April 27, 2021): 40–51. http://dx.doi.org/10.12944/crnfsj.9.1.05.

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The interrelation between arrhythmias and lifestyle factors is acknowledged. On the one side, there is a recognized interaction between atrial fibrillation and obesity, hypertension, dyslipidemia and type 2 diabetes mellitus. Saturated fats, excessive added salt, tea, coffee and energy drinks are often deleterious in rhythm disorders. The role of others, such as cocoa-rich foods, is less evident: several authors displayed the beneficial effect of the polyphenols content on numerous cardiovascular risk factors, while little is known about the potential link between diet and incident arrhythmias. Arrhythmias’ most frequent risk factors include aging, hypertension, congenital cardiopathy, heart failure, valvulopathy, thyroid diseases and diabetes. Nevertheless numerous arrhythmias are not related to any of these risk factors: in these cases, immunological, functional and even nutritional mechanisms might be involved in dysrhythmias’ genesis. Aim of this narrative review is to analyze the potential adverse effect of cocoa excessive consumption on cardiac rhythm and its mechanisms and to provide state-of-the-art knowledge on this topic.

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Vasquez-Rodríguez, Juan Felipe, Héctor Manuel Medina, Jaime Ramón Cabrales, and Adriana Gisella Torres. "MitraClip® as bridging strategy for heart transplantation in Chagas cardiomyopathy: a case report." European Heart Journal - Case Reports 4, no. 1 (January 18, 2020): 1–5. http://dx.doi.org/10.1093/ehjcr/ytz238.

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Abstract Background Patients with end-stage heart failure, suffering from severe pulmonary hypertension (PH) and elevated pulmonary vascular resistance, are not eligible for heart transplant due to high mortality risk and primary graft dysfunction. Severe PH may be favoured by functional severe mitral regurgitation, which is present in many cardiopathies like end-stage Chagasic cardiomyopathy. Case summary We present a case of a young man with end-stage heart failure secondary to Chagas cardiomyopathy with severe functional mitral regurgitation (FMR) and severe PH. The patient received percutaneous correction with MitraClip® system reducing PH and making him a suitable candidate for heart transplant. Discussion In patients with advanced heart failure, FMR, and severe PH, optimal treatment according to current guide lines is recommended. MitraClip® therapy appears to be safe and effective for control of severe PH as a bridge measure for cardiac transplantation.

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Carratala-Munuera, Concepción, Adriana Lopez-Pineda, Domingo Orozco-Beltran, Jose A. Quesada, Jose L. Alfonso-Sanchez, Vicente Pallarés-Carratalá, Cristina Soriano-Maldonado, Jorge Navarro-Perez, Vicente F. Gil-Guillen, and Jose M. Martin-Moreno. "Gender Inequalities in Diagnostic Inertia around the Three Most Prevalent Cardiovascular Risk Studies: Protocol for a Population-Based Cohort Study." International Journal of Environmental Research and Public Health 18, no. 8 (April 12, 2021): 4054. http://dx.doi.org/10.3390/ijerph18084054.

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Evidence shows that objectives for detecting and controlling cardiovascular risk factors are not being effectively met, and moreover, outcomes differ between men and women. This study will assess the gender-related differences in diagnostic inertia around the three most prevalent cardiovascular risk factors: dyslipidemia, arterial hypertension, and diabetes mellitus, and to evaluate the consequences on cardiovascular disease incidence. This is an epidemiological and cohort study. Eligible patients will be adults who presented to public primary health care centers in a Spanish region from 2008 to 2011, with hypertension, dyslipidemia, or/and diabetes and without cardiovascular disease. Participants’ electronic health records will be used to collect the study variables in a window of six months from inclusion. Diagnostic inertia of hypertension, dyslipidemia, and/or diabetes is defined as the registry of abnormal diagnostic parameters—but no diagnosis—on the person’s health record. The cohort will be followed from the date of inclusion until the end of 2019. Outcomes will be cardiovascular events, defined as hospital admission due to ischemic cardiopathy, stroke, and death from any cause. The results of this study could inform actions to rectify the structure, organization and training of health care teams in order to correct the inequality.

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Cocco, Giuseppe, and Armen Yuri Gasparyan. "A case report of a patient with Ribbing disease underlines the connections between the skeletal and cardiovascular complications." Clinics and Practice 1, no. 3 (June 22, 2011): 45. http://dx.doi.org/10.4081/cp.2011.e45.

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A 69-year-old woman suffered from Ribbing disease, a hereditary X autosomal dominant disease with multiple sclerosing dysplasias. However, it is less known that the genetic mutation can often induce cardiovascular complications. The patient had a hypertensive cardiopathy and had been treated with percutaneous coronary angioplasty and stenting because of a myocardial infarction. She was seen because of dyspnea and we detected an aneurysm of the ascending thoracic aorta. The patient underwent surgical repair. In Ribbing disease an up-regulation of genes interferes with the production, processing, or formation of collagen type II and XI. These genetic effects are thought to be specific for osteoblasts and are responsible for the skeletal pathology. However, the defective synthesis of collagen can also induce cardiovascular complications which may be similar to those described in patients with type III Ehlers-Danlos syndrome, with type IV Marfan syndrome, and with osteogenesis imperfecta. Rheumatologists who treat patients with Ribbing disease should seek the advice of cardiologists for the occurrence of cardiovascular complications.

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Puente, Dolores, Cecilia Colorio, Roxana Ratto, Martin Descalzo, Andrea Rossi, Francisco Perea, Mirta Diez, et al. "Clinical Implications of Anemia in Heart Failure (HF) Patients (pts)." Blood 110, no. 11 (November 16, 2007): 3776. http://dx.doi.org/10.1182/blood.v110.11.3776.3776.

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Abstract Previous studies have shown that anemia is frequently associated with higher morbidity and mortality in HF pts. Our aim was to determine the impact of anemia in pts hospitalized with congestive HF at our hospital. We analyzed data from 277 pts with diagnosis of HF admitted between 1 June 2004 and 31 December 2005, with a follow up of at least 6 months. Anemia was defined as hemoglobin (Hb) <11,5 g/dl. HF was classified according to Framingham criteria. Previous history of arterial hypertension, diabetes, dislipemia, chronic renal insufficiency and ACE inhibitors treatment was recorded. Ischaemic and non- ischaemic etiology of cardiopathy was established. Renal disfunction was defined as creatinin concentraction >1.9 mg/dl. Pts with HF were assigned to group A (with anemia) or B (control). Statistical analysis was performed using Pearson’s Chi square, Spearman’s rho, Fisher test and Kaplan Meyer survival function. Results: We evaluated 229 (82,7%) pts with a median follow up of 594 days (range: 1–1129 days). Mean age was 68,02 years (median 71, range: 17–91). 143/229 (62,4%) were male. In 75 /229 (32.75%) cases a Hb < 11,5 g/dl was measured at admission. The mean Hb was 13,1 g/dl for the entire group. Anemia pts showed a mean Hb of 10.6 g/dl. Demographic, clinical and outcome features are shown in table 1.Group A showed a higher number of readmissions because of HF and other cardiac. Conclussions: In our analysis the prevalence of anemia was 33% in pts hospitalized for HF. There was no significant differences among clinical variables between anemic and non-anemic pts. Anemia was associated with worse clinical outcome (Group A pts required more readmissions for HF and other cardiological causes)and all cause mortality. Mean survival was longer in Group B pts.according to Kaplan Meyer analysis. TABLE 1: RESULTS GROUP A (n=75) GROUP B (n= 154) p Male 42 (56%) 101 (65.5%) Mean age (years) 70.38 (R:20–90) 67.1 (R:17–91) Mean Hb (g/dl) 10.6 14.3 Ischaemic cardiopathy 38(50,6%) 78(50.6%) Non ischaemic cardiopathy 41(54,6%) 78 Arterial hypertension 54(72%) 106(68.8%) Diabetes 24(32%) 33(21.4%) Dislipaemia 35(46.6%) 64(41.5%) Chronic renal insufficiency 18(24%) 19(12.3%) 0.03 Previous ACE inhibitors treatment 25(33%) 71(46%) 0.08 Acute pulmonary edema 12(16%) 15(9.7%) Creatinin concentration > 1.9 mg/dl 16(21.3%) 18 (11.6%) Hospitalization days (mean) 9.6 (R: 1–51) 8.1(R:1–59) Readmission for HF 37 190 0.001 Readmission for other cardiologic causes 20 109 0.017 Readmission for non cardiologic diseases 18 58 Mean survival (days) 499 (R:1–1091) 658 (r=1–1129) 0.166 Global mortality 25 (33%) 32(21%) 0.05 HF related mortality 13 (20.9%) 24 (14.3%) Figure Figure

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Pop, Horia F., Tudor L. Pop, and Costel Sarbu. "Assessment of Heart Disease using Fuzzy Classification Techniques." Scientific World JOURNAL 1 (2001): 369–90. http://dx.doi.org/10.1100/tsw.2001.64.

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In this paper we discuss the classification results of cardiac patients of ischemical cardiopathy, valvular heart disease, and arterial hypertension, based on 19 characteristics (descriptors) including ECHO data, effort testings, and age and weight. In this order we have used different fuzzy clustering algorithms, namely hierarchical fuzzy clustering, hierarchical and horizontal fuzzy characteristics clustering, and a new clustering technique, fuzzy hierarchical cross-classification. The characteristics clustering techniques produce fuzzy partitions of the characteristics involved and, thus, are useful tools for studying the similarities between different characteristics and for essential characteristics selection. The cross-classification algorithm produces not only a fuzzy partition of the cardiac patients analyzed, but also a fuzzy partition of their considered characteristics. In this way it is possible to identify which characteristics are responsible for the similarities or dissimilarities observed between different groups of patients.

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Walther, T., S. Heringer-Walther, R. Tschope, A. Reinecke, HP Schultheiss, and C. Tschope. "Opposite regulation of brain and C-type natriuretic peptides in the streptozotocin-diabetic cardiopathy." Journal of Molecular Endocrinology 24, no. 3 (June 1, 2000): 391–95. http://dx.doi.org/10.1677/jme.0.0240391.

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C-type natriuretic peptide (CNP), a recent addition to the family of natriuretic peptides including atrial and brain natriuretic peptide (ANP, BNP), is believed to be an endothelium-derived vasodilator and to have an antimitotic effect. ANP and BNP concentrations are increased in conditions such as congestive heart failure, but cardiac CNP concentrations have not been investigated in this connection. Diabetes mellitus also involves myocardial dysfunctions without coronary artery disease or systemic hypertension. We therefore investigated the cardiac expression of CNP mRNA compared with that of BNP mRNA in streptozotocin (STZ)-diabetic rats. STZ- diabetic male Wistar rats (n=6) were studied in comparison with controls (n=6). The animals were characterised by their mean arterial blood pressure and plasma glucose concentrations. After extraction of total cardiac RNA, a specific cDNA probe of BNP was used for northern blot analysis, whereas myocardial CNP expression was analysed by an RNase-protection assay. Twelve weeks after diabetes was induced, the rats were normotensive (96.4+/-2.0 compared with 95.1+/-1.9 mmHg) and hyperglycaemic (615+/-61 compared with 165+/-21 mg/dl; P<0.001). Left ventricular pressure was significantly impaired (76.8+/-6.4 compared with 51.2+/-3.6 mmHg). STZ-diabetic rats had a 3.2-fold increase in cardiac BNP expression compared with controls. In contrast, cardiac CNP mRNA concentrations were decreased 2.6-fold. CNP seems to be downregulated like other peptides with antimitotic and vasodilator activities (nitric oxide, prostacyclin, kinins). This may contribute to cardiac dysfunction in diabetes mellitus and suggests that stimulation of CNP expression could provide cardiac protection in such cases.

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Obrezan, A. G., A. E. Filippov, and A. A. Obrezan. "A patient with atrial fibrillation and diabetes: selecting the optimal anticoagulant therapy regimen." Russian Journal of Cardiology 26, no. 5 (June 11, 2021): 4508. http://dx.doi.org/10.15829/1560-4071-2021-4508.

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Atrial fibrillation (AF) is a common arrhythmia in patients with type 2 diabetes (T2D). Patients with diabetes are at higher risk of AF than those without it. There is an increased risk of dysglycemia in AF. Patients with AF and concomitant diabetes are more likely to have coronary artery disease, hypertension, heart failure, while strokes in patients with AF and diabetes are more severe. Diabetes, in turn, causes the angiopathies and cardiopathy. There is a higher risk of both thrombotic and bleeding events in patients with AF and T2D. The article discusses the mutual burden of T2D and AF, as well as the risk scores for thrombotic, thromboembolic, and bleeding events. Anticoagulant therapy takes a special place in improving the prognosis in AF patients. Numerous studies and actual clinical practice have demonstrated the effectiveness of anticoagulants in the prevention of stroke and other comorbidities.

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Carvalho, Werther Brunow de, Antonio Carlos Camargo Carvalho, Gisele Limongeli Gurgueira, Angela Mityo Ikeda, June Ho Lee, and Dirceu Rodrigues Almeida. "Inhaled nitric oxide and high concentrations of oxygen in pediatrics patients with congenital cardiopathy and pulmonary hypertension: report of five cases." Sao Paulo Medical Journal 116, no. 1 (February 1998): 1602–5. http://dx.doi.org/10.1590/s1516-31801998000100002.

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Five patients with ages ranging from 6 months to 3 years were analyzed. All received inhaled nitric oxide (NO - 20 parts per million (ppm) ) and oxygen (0(2) - at a concentration of 90-95%) by means of an oxygen hood. Mean Pulmonary Artery Pressure (MPAP), Mean Aortic Pressure (MAoP), Pulmonary Vascular Resistance (PVR) and Systemic Vascular Resistance (SVR) were measured and the calculation of their relationship to pulmonary/systemic flow (Qp/Qs) was performed by the catheterization' of the femoral artery vein. Three patients presented reduction in PVR and increase in Qp/Qs. There were no systemic alterations or any side effect from using NO.

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Vale, Francisco A. C., and Stênio J. C. Miranda. "Clinical and demographic features of patients with dementia attended in a tertiary outpatient clinic." Arquivos de Neuro-Psiquiatria 60, no. 3A (September 2002): 548–52. http://dx.doi.org/10.1590/s0004-282x2002000400006.

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We describe clinical and socio-demographic features of patients with dementia attended in a tertiary outpatient clinic during a three years period (56.9% of the total attendance). Most of them were men, white, from the local community, urban district. Nobody had a job at the moment, two thirds of them got social welfare benefit. They lived with their family, the caregiver being the spouse or a daughter. The education level was very low, a quarter of them being illiterate. They were referred mostly from the public health care service, by neurologists or psychiatrists due to cognitive disorders. Family history as well as individual history of previous neurological/psychiatric disorders were frequent, especially alcoholism, stroke, head trauma and dementia. The neurological exam showed abnormalities in two thirds of cases, chiefly extra-pyramidal and pyramidal signs. Alzheimer's disease was the most frequent cause, followed by cerebrovascular disorder; alcoholism and normal pressure hydrocephalus were also frequent causes. Most patients presented concomitant non-etiological neurological/psychiatric disorders, mainly alcoholism and depression, and non-neurological/psychiatric diseases, predominantly hypertension, cardiopathy and diabetes. Most patients had been referred under medication, frequently politherapy, including psychotropics.

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Favre, Guillaume A., Vincent L. M. Esnault, and Emmanuel Van Obberghen. "Modulation of glucose metabolism by the renin-angiotensin-aldosterone system." American Journal of Physiology-Endocrinology and Metabolism 308, no. 6 (March 15, 2015): E435—E449. http://dx.doi.org/10.1152/ajpendo.00391.2014.

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The renin-angiotensin-aldosterone system (RAAS) is an enzymatic cascade functioning in a paracrine and autocrine fashion. In animals and humans, RAAS intrinsic to tissues modulates food intake, metabolic rate, adiposity, insulin sensitivity, and insulin secretion. A large array of observations shows that dysregulation of RAAS in the metabolic syndrome favors type 2 diabetes. Remarkably, angiotensin-converting enzyme inhibitors, suppressing the synthesis of angiotensin II (ANG II), and angiotensin receptor blockers, targeting the ANG II type 1 receptor, prevent diabetes in patients with hypertensive or ischemic cardiopathy. These drugs interrupt the negative feedback loop of ANG II on the RAAS cascade, which results in increased production of angiotensins. In addition, they change the tissue expression of RAAS components. Therefore, the concept of a dual axis of RAAS regarding glucose homeostasis has emerged. The RAAS deleterious axis increases the production of inflammatory cytokines and raises oxidative stress, exacerbating the insulin resistance and decreasing insulin secretion. The beneficial axis promotes adipogenesis, blocks the production of inflammatory cytokines, and lowers oxidative stress, thereby improving insulin sensitivity and secretion. Currently, drugs targeting RAAS are not given for the purpose of preventing diabetes in humans. However, we anticipate that in the near future the discovery of novel means to modulate the RAAS beneficial axis will result in a decisive therapeutic breakthrough.

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IWAKURA, Masaki, Yoshiro SHIBUYA, Yoko YASUNO, and Yoshihiro SHIMADA. "Prevalence of Gingival Hyperplasia in Adults Receiving a Health Examination in a Rural Area, in Reference to Medications for Hypertension and Cardiopathy." JOURNAL OF DENTAL HEALTH 41, no. 3 (1991): 289–93. http://dx.doi.org/10.5834/jdh.41.289.

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Todea-Moga, Ciprian, Radu Boja, Daniel Porav-Hodade, Adrian Maier, Oliver Vida, and Orsolya Mártha. "The Impact of Comorbidities on the Efficacy of Percutaneous Nephrolitotomy (PCNL) in Elderly Patients." Acta Medica Marisiensis 62, no. 2 (June 1, 2016): 243–47. http://dx.doi.org/10.1515/amma-2016-0025.

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AbstractIntroduction: The objective of this study is to evaluate the efficacy and safety of PCNL as a method of treatment of renal stones in elderly patients.Material and method: This was a retrospective study conducted over a period of 5 years in the Clinic of Urology, where we analyzed the surgical protocols and case reports of 56 patients who underwent PCNL intervention.Results: The incidence of urolithiasis was higher in females 69.6% (n = 39) than in males 30.4% (n = 17). Comorbidities included hypertension (48.2%), chronic ischemic cardiopathy (28.6%), chronic cardiac failure (16.1%), type II diabetes (17.9%), obesity (39.3%), chronic renal failure (8.9%), chronic or recurrent urinary tract infections (30.4%), history of kidney stones (21.4%), solitary kidney surgery (1.8%), renal malformation (horseshoe kidney and renal incomplete duplication) (3.6%), urethral stricture (3.6%). Nine patients had a duble “J” catheter inserted on admission. The group of male patients presented prostate hyperplasia in 35.3% of the cases and prostate carcinoma in 5.9% of the cases.Conclusions: PCNL is an effective and safe treatment of kidney stones in elderly patients, with a stone- free rate increased despite existing comorbidities. The presence of comorbidities requires careful preoperative evaluation. PCNL in elderly patient has similar results to those seen in younger patients.

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Santos, Ariane Gomes dos, Elaínny Cristina Rocha Fernandes, Evelyn Matias Pontes Barbosa, Kayo Alves Figueiredo, and Danielle Benigno de Andrade. "Arterial hypertension and associated risk factors in teachers / Hipertensão arterial e fatores de risco associados em docentes / Hipertensión arterial y factores de riesgo asociados en maestros." Revista de Enfermagem da UFPI 6, no. 3 (September 1, 2017): 37. http://dx.doi.org/10.26694/reufpi.v6i3.5880.

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Objetivo: identificar fatores associados à pressão arterial elevada em docentes de um Instituto Federal de Educação, ciência e Tecnologia do Piauí. Metodologia: trata-se de estudo transversal. Os participantes do estudo foram 150 docentes. O instrumento de coleta de dados foi um questionário seguido da verificação de pressão arterial dos docentes. A pesquisa foi aprovada pelo comitê de ética e pesquisa, com número de CAAE: 38967414.3.0000.5209. O período de coleta de dados foi de março a abril de 2015. Para análise foram utilizados testes de Qui-quadrado e exato de Fisher. Resultados: 25,33% dos indivíduos analisados apresentaram níveis pressóricos altos, 65,33% dos docentes eram do sexo masculino, as faixas etárias mais frequentes foram 30-39 anos (34,67%) e 40-49 anos (34,67%). Houve associação estatisticamente significativa entre a hipertensão e os fatores: sexo (p=0,0001), faixa de idade (p=0,0483), estado civil (p=0,0218), cor da pele autodeclarada (p=0,0051), cardiopatia (p=0,036), uso de bebida alcoólica (p=0,036), índice de massa corporal - IMC (p<0,05) e circunferência abdominal (p=0,004). Conclusão: foi possível identificar fatores que estão relacionados à hipertensão em docentes de um Instituto Federal do Piauí. Recomenda-se aos docentes a adequação do estilo de vida para uma melhor qualidade de vida.

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Rigacci, Luigi, Silvia Mappa, Luca Nassi, Renato Alterini, Valentina Carrai, Franco Bernardi, and Alberto Bosi. "Liposomal Doxorubicin in the Treatment of Elderly, Cardiopatic, or Pretreated Patients with Aggressive Lymphomas: Comparison with an Historical Series." Blood 108, no. 11 (November 16, 2006): 4685. http://dx.doi.org/10.1182/blood.v108.11.4685.4685.

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Abstract The majority of patients (pts) with diffuse large-B cell lymphoma (DLBCL) are elderly and may have limited tolerance to chemotherapy due to concomitant diseases. Non-pegylated liposomal doxorubicin has an improved therapeutic index in comparison to doxorubicin, resulting in less myelosuppression, lower GI toxicity and reduced risk of cardiotoxicity at dose level equivalent to standard formulations of doxorubicin. The aim of this study was to assess the efficacy and feasibility of the combination of cyclophosphamide, vincristine, prednisone and liposomal doxorubicin with rituximab every three weeks (R-COMP21) in DLBCL elderly pts with concomitant disease or relapsed pts pre-treated with anthracyclines containing regimens. We analysed twenty-five not consecutive pts from June 2003 to December 2005 according to following negative characteristics: 5 pts over 75 years (20%), 8 pts pretreated with anthracyclines (32%), 12 pts (48%) with heart disease (5 ischemic, 2 hypokinetic and 5 hypertensive cardiomiopathy). Median age was 71 years (range 54–76). 3 pts were stage I, 6 stage II, 5 stage III and 11 stage IV. According to IPI score 8 pts were low risk, 9 low-intermediate, 7 intermediate-high and 1 high risk. The median left ventricular ejection fraction (LVEF) at diagnosis was 59% (range 42%–75%). All pts were evaluable for response to therapy: 18 (72%) obtained a complete remission (62,5% in pre-treated pts), 5 (20%) obtained a partial remission with an overall response rate of 92%. Two pts did not respond to therapy. After a total of 126 cycles we observed three toxic event (congestive heart failure, stroke and gastrointestinal bleeding). No significant hematological toxicity was recorded. Four percent of cycles were delayed. Median final LVEF was 57% (47%–65%). All pts but one had no change in LVEF, one patient developed a congestive heart failure resolved with medical therapy: he was withdrawn due to decrease of LVEF. After a median observation period of 2 years (range 2–68 months), 71% of pts are alive, five pts died two due toxicity and three due to progressive disease. We compared these outcomes with an historical control of 26 aggressive NHL pts treated from February 2001 to June 2005; these pts received no doxorubicin (10 pts) or a mitoxantrone-based scheme devised for elderly (16 pts) due to age or concomitant disease. Case matching was performed with respect to clinical stage, IPI, sex, symptoms, bulky disease, LVEF, with the exception of age (which was greater in control group: median 76 vs 71 p=.001) and heart disease which was more frequent in experimental group (48% vs 31% p=.02). Allowing for the limitations of studies using historic controls, the R-COMP regimen was associated with higher CR (72% vs 42%) and OS rates (71% vs 42%). These results did not change when only pts treated with rituximab are considered. We conclude that the general tolerability and the low incidence of cardiac events of liposomal doxorubicin warrants further studies in a subset of pts with concomitant disease limiting the use of conventional anthracyclines.

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Salvi, Flavia, Michele Spina, Alessandro Pulsoni, Sergio Storti, Alessandra Tucci, Marianna Chiozzotto, Stefania Massidda, et al. "Multicenter Study with Mbvd Regimen in Elderly or Younger Patients with Cardiac Disorders Affected By Hodgkin’s Lymphoma. a Phase II Study on Behalf of the Fondazione Italiana Linfomi (FIL)." Blood 124, no. 21 (December 6, 2014): 1732. http://dx.doi.org/10.1182/blood.v124.21.1732.1732.

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Abstract Backgrounds: ABVD is considered the standard of care for Hodgkin’s Lymphoma (HL) patients; however few prospective studies have evaluated his efficacy and safety in elderly patients. Moreover anthracycline-based chemotherapy is not feasible in patients with moderate/severe concomitant heart disease. In comparison with conventional doxorubicin, non–pegylated liposomal doxorubicin (TLC-D99; Myocet ™) has shown a selective uptake and a reduced clearance by the tumor cells resulting in improved cardiac safety. Purpose: Aim of the study was to investigate efficacy and safety of an ABVD-like regimen with non-pegylated liposomal doxorubicin (TLC-D99; Myocet ™) instead of conventional doxorubicin. Patients and Methods : From March 2010 to January 2013, 41 non-frail elderly (age³ 70) and 6 younger cardiopathic patients with untreated HL were enrolled by 22 FIL centers. “Non-frail” definition was based on less than 3 grade CIRS-G co-morbidities, no grade 4 CIRS-G and no geriatric syndrome at diagnosis. Cardiac disorder was defined according to the presence of at least one of the following: left ventricular ejection fraction (LVEF) < 50%, left ventricular hypertrophy, uncontrolled moderate/severe arterial hypertension, history of ischemic cardiopathy, clinically significant ventricular arrhythmia, atrial fibrillation, pulmonary hypertension, moderate/severe mitral valvular disorder, moderate aortic valvular disorder. For advanced disease (IIB-IV) the treatment plan was 6 courses of MBVD ( Myocet 25 mg/m2; bleomycin 10 mg/m2; vinblastine 6 mg/m2; dacarbazine 375 mg/m2) plus radiotherapy (RT) on bulky disease or residual PET positive area; for early stages (I-IIA) the treatment plan was 3 courses of MBVD plus RT involved field (IF). Preventive use of granulocyte growth factors was recommended in elderly patients; erythropoietin treatment was considered for all patients if the haemoglobin value was < 11 gr/dl. The two primary objectives of the study were to evaluate the complete remission (CR) rate according to international criteria (Cheson 2007) and the rate of cardiac events (CE) defined as a reduction of LVEF ³ 15% from baseline or the occurrence of any significant cardiac disorder. Results. Patients’ median age was 75 (range 46–84); thirteen patients (28%) were in early stage and the remaining 34 (72%) in advanced stage. According to CGA-G scale one or more G2-3co-morbidities were present in 28 patients (60%). All the 13 early stages patients regularly ended the three planned courses of chemotherapy in an outpatients setting without complications; 1 of them refused subsequent RT IF. Among the advanced stage, 13 out 34 patients (38%) interrupted their treatment, mainly from course three to six, for the following reasons: 9 for severe toxicity; 1 for disease progression; 2 for poor compliance or consent retirement; 1 for lung cancer. Fifty-one % of patients experienced at least one episode of grade 3-4 haematological toxicity; severe infections were reported in 3 patients (6%); grade 4 acute cardiac toxicity in only 1 patient. A LVEF reduction ³ 15% from baseline was never documented. The final CR rate was 100% in early stage and 68% in advanced stage patients. At a median follow-up of 28 months all patients with early disease are alive and in CR. In advanced stage patients the 30 months actuarial OS rate is 62%, while the 30 months actuarial PFS rate is only 34% with a median PFS of 20 months. So far, 10 advanced patients have died: 3 of HL; 3 of acute toxicity including 1 sepsis, 1 pneumonia and 1 myocardial infarction, resulting in a 6% treatment-related mortality (TRM); moreover 2 patients died of lung cancer diagnosed within 7 months after the end of their treatment; 1 of heart failure and 1 of pneumonia, thrombocytopenia and gastrointestinal bleeding , both 1 year later the end of treatment. Acute and late CE with fatal exit from the study occurred in 2 patients (4%). Conclusions: In elderly patients with advanced disease MBVD shows an unfavourable toxic profile, not really different from ABVD, even if cardiac toxicity was spared. Prospective studies with baseline definition of comorbidity score and new less aggressive strategies are needed. Disclosures Off Label Use: Lenalidomide in MCL. Spina:Teva: Honoraria.

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Staub, Henrique Luiz, Gary Lewis Norman, Tiffany Crowther, Viviane Roseli da Cunha, Aline Polanczyk, Jussara Maria Bohn, Jefferson Gomes Fernandes, Wiliam Habib Chahade, and Carlos Alberto von Mühlen. "Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischemia." Arquivos de Neuro-Psiquiatria 61, no. 3B (September 2003): 757–63. http://dx.doi.org/10.1590/s0004-282x2003000500010.

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One third of cases of cerebral ischemia have no clear etiology. A humoral response to the atherosclerotic plaques components beta2-glycoprotein l (beta2-gpl) and heat-shock proteins (Hsp) might be involved in the pathogenesis of stroke. This case-control study includes a complete profile of anti-beta2-gpl antibodies and testing of IgG antibodies to the 60/65 kilodaltons (kDa) Hsp in stroke patients. Ninety-three patients with acute ischemic stroke and 93 controls were evaluated for age, sex, race, hypertension, smoking, previous cardiopathy, diabetes mellitus, hypercholesterolemia and previous history of cerebral ischemia. lgG/lgM/lgA anticardiolipin (aCL) and anti-beta2-gpl antibodies, as well as lgG antibodies to human 60 kDa Hsp and to Mycobacterium bovis 65 kDa Hsp, were detected by immunoassay. Adjusted odds ratios (OR) were calculated by logistic regression. The adjusted OR for IgA anti-beta2-gpl antibodies was 4.6 (90%Cl 1.5 to 14.3; p = 0.025). The non-adjusted OR for IgG antibodies to Hsp 60 was 26.1. The adjusted OR for IgG antibodies to Hsp 65 was 3.2 (90%Cl 1.2 to 8.3; p = 0.044). The adjusted OR for lgG to any Hsp (60 or 65) was 4.8 (90%Cl 1.9 to 12.1; p = 0.006). This study demonstrates that elevated IgA anti-beta2-gpl and lgG anti-Hsp 60/65 antibodies are associated with increased risk of ischemic stroke. The association occurred independently of other risk factors. This humoral response might link autoimmunity, thrombophilia and atherosclerosis in stroke patients.

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Pandolfi, Sergio, Claudio Di Giovanni, Eleonora Marinari, and Marianno Franzini. "Improvement of neurological conditions and recovery of the left ventricular ejection fraction subsequent to oxygen-ozone therapy through auto-hemoinfusion of ozonated blood." Ozone Therapy 1, no. 1 (April 5, 2016): 10. http://dx.doi.org/10.4081/ozone.2016.5840.

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Here we present the case of a 76-year-old patient who suffered from ischemic cardiopathy and myocardial infarction in January 2014, arterial hypertension, kidney failure, Parkinsonism, vascular multinfarctual ischemic cerebropathy, cerebral ictus, neurogenic bladder, and inguinal hernia. The left ventricular ejection fraction evaluated through repeated echocardiographic examinations remained reduced to 33% from January 2014 to March 2015. The left ventricular ejection fraction, after 14 months from acute myocardial infarction and despite the coronary angioplasty and medical therapy, remained constantly reduced to 33%. On 3<sup>rd</sup> July 2015 he started the oxygen-ozone therapy with 2 autohemoinfusions of ozonated blood per week. Over the first two months of therapy we noticed a marked improvement of his heart conditions with a net reduction in asthenia and neurological status, the improvement of heart conditions was corroborated by the echocardiogram of 5<sup>th</sup> November 2015 which showed an increase in the left ventricular ejection fraction from 33% to 50%. In this case the heart function improvement of left ventricular ejection fraction was noticed only after having started the systemic oxygen-ozone therapy through large autohemoinfusion. In April 2015, before starting the oxygen-ozone therapy we assessed the patient’s inguinal hernia to be inoperable due to the lapsed heart conditions, while the subsequent reassessment in December 2015, after the patient underwent oxygen-ozone therapy for 5 months, we assessed him to be operable considering the heart function improvement.

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D'Amico, A., V. Ficarra, A. Porcaro, R. Puce, S. Cicuto, G. Malossini, and C. Tallarigo. "L'eziopatogenesi della fibrosi retroperitoneale: Etiopathogenesis of retroperitoneal fibrosis." Urologia Journal 65, no. 2 (April 1998): 257–66. http://dx.doi.org/10.1177/039156039806500213.

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The etiopathogenesis of retroperitoneal fibrosis is still obscure and probably multifactorial. Among the secondary forms due to demonstrable causes, the one caused by aorto-iliac atherosclerosis has recently been recognised. Its pathogenesis is linked to the low density oxidised lipoproteins of the atheromatous plaque, which are responsible for a local immunologic reaction. The most common form is still idiopathic or primitive, hypothetically related to genetic, environmental, vascular and/or immunologic factors. Idiopathic retroperitoneal fibrosis is sometimes associated with other sclerosing syndromes and/or systemic diseases. In such cases a common pathogenesis, probably immunologic may be postulated. After having illustrated the different categories of retroperitoneal fibrosis, the authors report their experience with 25 patients of whom 14 had idiopathic fibrosis and 11 secondary fibrosis. In the former group 11 patients (78.5%) smoked more than 10 cigarettes a day, while there was a history of prolonged professional exposure to asbestos in one case. The following associated pathologies were observed: hypertension in 7 cases (50%), ischemic cardiopathy in 2 (14.3%), diabetes mellitus in 2 (14.3%), multiple myeloma in 1 (7.1%) and juvenile rheumatoid arthritis in 1 (7.1%). The disease was also associated with other sclerosing pathologies in 3 cases: sclerosing cholangitis in 2 and Dupuytren's contracture in 1. The location of the fibrosis was typically periaortic in 13 cases (92.8%), as shown by CT. Lastly, 10 patients underwent immunosuppressive therapy with a favourable response, suggesting the probable immunologic pathogenesis of the disease.

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Rubio-Rivas, Manuel, Xavier Corbella, José María Mora-Luján, Jose Loureiro-Amigo, Almudena López Sampalo, Carmen Yera Bergua, Pedro Jesús Esteve Atiénzar, et al. "Predicting Clinical Outcome with Phenotypic Clusters in COVID-19 Pneumonia: An Analysis of 12,066 Hospitalized Patients from the Spanish Registry SEMI-COVID-19." Journal of Clinical Medicine 9, no. 11 (October 29, 2020): 3488. http://dx.doi.org/10.3390/jcm9113488.

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(1) Background: Different clinical presentations in COVID-19 are described to date, from mild to severe cases. This study aims to identify different clinical phenotypes in COVID-19 pneumonia using cluster analysis and to assess the prognostic impact among identified clusters in such patients. (2) Methods: Cluster analysis including 11 phenotypic variables was performed in a large cohort of 12,066 COVID-19 patients, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish Society of Internal Medicine (SEMI)-COVID-19 Registry. (3) Results: Of the total of 12,066 patients included in the study, most were males (7052, 58.5%) and Caucasian (10,635, 89.5%), with a mean age at diagnosis of 67 years (standard deviation (SD) 16). The main pre-admission comorbidities were arterial hypertension (6030, 50%), hyperlipidemia (4741, 39.4%) and diabetes mellitus (2309, 19.2%). The average number of days from COVID-19 symptom onset to hospital admission was 6.7 (SD 7). The triad of fever, cough, and dyspnea was present almost uniformly in all 4 clinical phenotypes identified by clustering. Cluster C1 (8737 patients, 72.4%) was the largest, and comprised patients with the triad alone. Cluster C2 (1196 patients, 9.9%) also presented with ageusia and anosmia; cluster C3 (880 patients, 7.3%) also had arthromyalgia, headache, and sore throat; and cluster C4 (1253 patients, 10.4%) also manifested with diarrhea, vomiting, and abdominal pain. Compared to each other, cluster C1 presented the highest in-hospital mortality (24.1% vs. 4.3% vs. 14.7% vs. 18.6%; p < 0.001). The multivariate study identified age, gender (male), body mass index (BMI), arterial hypertension, chronic obstructive pulmonary disease (COPD), ischemic cardiopathy, chronic heart failure, chronic hepatopathy, Charlson’s index, heart rate and respiratory rate upon admission >20 bpm, lower PaO2/FiO2 at admission, higher levels of C-reactive protein (CRP) and lactate dehydrogenase (LDH), and the phenotypic cluster as independent factors for in-hospital death. (4) Conclusions: The present study identified 4 phenotypic clusters in patients with COVID-19 pneumonia, which predicted the in-hospital prognosis of clinical outcomes.

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Asmare, Melkamu H., Frehiwot Woldehanna, Samuel Hunegnaw, Luc Janssens, and Bart Vanrumste. "Prevalence of rheumatic heart disease in a major referral cardiology clinic in Ethiopia: A retrospective cross-sectional study." PLOS ONE 16, no. 2 (February 16, 2021): e0246519. http://dx.doi.org/10.1371/journal.pone.0246519.

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Background Rheumatic Heart Disease (RHD) remains one of the major causes of death and disability in developing countries. This preventable, treatable but not curable form of cardiovascular disease is needlessly killing scores of children and youth mainly due to the misunderstanding of the burden of the disease in these countries. We sought to describe the prevalence of RHD at one of the major referral cardiology clinics in Ethiopia. Methods This was a retrospective cross-sectional chart review of all patients referred for a cardiopathy at the Tikur Anbessa Referral Cardiac Clinic from June 2015 to August 2018. We excluded records of patients with a non-cardiac diagnosis and those without a clear diagnosis. A predesigned and tested EXCEL form was used to collect the data. The data was encoded directly from the patient record files. MATLAB’s statistics toolbox (MATLAB2019b) was used for statistical analysis. Results Among the total 7576 records analyzed 59.5% of the patients were women. 83.1% of the data belonged to adult patients with the largest concentration reported in the 18 to 27 age group. 69.7% of the patients were from urban areas. The median age of the study population was 30 (interquartile range = 21–50). 4151 cases were caused by RHD which showed that RHD constituted 54.8% of the cases. The median age for RHD patients was 25 (interquartile range = 19–34). The second most prevalent disease was hypertensive heart disease which constituted 13.6% that was followed by congenital heart disease with 9% prevalence rate. Conclusion The results of this study indicated the extent of the RHD prevalence in Ethiopia’s cardiac hospital was 54.8%. What was more critical was that almost 70% of the RHD patients were mainly the working-age group(19 to 34 years).

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MORENO, FUENSANTA, DÁMASO SANZ-GUAJARDO, JUAN MANUEL LÓPEZ-GÓMEZ, ROSA JOFRE, and FERNANDO VALDERRÁBANO. "Increasing the Hematocrit Has a Beneficial Effect on Quality of Life and Is Safe in Selected Hemodialysis Patients." Journal of the American Society of Nephrology 11, no. 2 (February 2000): 335–42. http://dx.doi.org/10.1681/asn.v112335.

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Target hematocrit/hemoglobin values in dialysis patients are still controversial. The Spanish Cooperative Renal Patients Quality of Life Study Group (including 34 hemodialysis units) conducted a prospective, 6-mo study of the effect on patient functional status and quality of life of using epoetin to achieve normal hematocrit in hemodialysis patients with anemia. The possible adverse effects of increased hematocrit, patient hospitalization, and epoetin requirements were also studied. The study included 156 patients (age range, 18 to 65 yr). Given the minimal experience in the safety of increasing hematocrit in dialysis patients to normal levels with epoetin, stable patients on hemodialysis who had received epoetin treatment for at least 3 mo and had a stable hemoglobin level of ≥9 g/dl were included in the study. Patients with antecedents of congestive cardiac failure, ischemic cardiopathy, diabetes mellitus, uncontrolled hypertension, cerebrovascular accident or seizures, malfunction of the vascular access or severe comorbidity (defined by a comorbidity index), and those over 65 yr of age were excluded from the study. Quality of life was measured with the Sickness Impact Profile (SIP) and Karnofsky scale. Patients completed questionnaires at home at onset and conclusion of the 6-mo study. Mean hematocrit increased from 30.9 to 38.4% and hemoglobin from 10.2 to 12.5 g/dl during the study. Health indicator scores improved significantly: mean Physical Dimension (SIP) from 5.38 to 4.1 (P < 0.005); mean Psychosocial Dimension from 9.2 to 7 (P < 0.001); mean global SIP from 8.9 to 7.25 (P < 0.001); mean Karnofsky scale score from 75.6 to 78.4 (P < 0.01). (SIP is scaled so that lower scores represent better functional status, and vice versa for the Karnofsky scale). Therefore, functional status and quality of life improved with increased hematocrit. No deaths occurred. Three patients (2%) were censored for hypertension and nine (5.7%) for thrombosis of the vascular access. The cumulative probability of thrombosis of the vascular access was 0.067. The average epoetin dose rose from 93 ± 62 U/kg per wk at onset to 141 ± 80 U/kg per wk at conclusion, a 51% increase. The number of patients hospitalized decreased and hospital lengths of stay were shorter during the study period than in the same patients in the 6-mo period preceding the study (P < 0.05). Nine patients (5.7%) had thrombosis of the vascular access. There were no changes in the prevalence of arterial hypertension, but three patients (2%) showed hypertension that was difficult to control. It is concluded that normalization of hematocrit in selected hemodialysis patients, i.e., nondiabetic patients without severe cardiovascular or cerebrovascular comorbidities, improves quality of life and decreases morbidity without significant adverse effects.

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Journal articles on the topic 'Cardiopathie hypertensive'

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