Relevant bibliographies by topics / CAS PO 223

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Academic literature on the topic 'CAS PO 223'

Author: Grafiati
Published: 27 July 2024
Last updated: 31 July 2025

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Journal articles on the topic "CAS PO 223"

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Karve, Kunal, Stephanie Poon, Panagiotis Prinos, and Laurie Ailles. "Abstract PO-077: High-throughput 3D-spheroid invasion assay: A powerful tool to identify novel drugs targeting tumor micro-environment in HNSCC." Clinical Cancer Research 29, no. 18_Supplement (2023): PO—077—PO—077. http://dx.doi.org/10.1158/1557-3265.aacrahns23-po-077.

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Abstract Cancer metastasis is a complex cascade that involves activation of cancer cell invasion and migration. This activation is greatly attributed by multiple factors, including the tumor-microenvironment (TME). Cancer-associated fibroblasts (CAF), a prominent cell type within the TME, have been shown to promote cancer cell invasion and migration, causing metastasis in various cancers including head and neck squamous cell carcinoma (HNSCC). The molecular mechanisms of how CAFs promote HNSCC invasion remain elusive. Our research goal is to understand how CAFs influence HNSCC cells to become
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Rothberg, Brad S., and Karl L. Magleby. "Voltage and Ca2+ Activation of Single Large-Conductance Ca2+-Activated K+ Channels Described by a Two-Tiered Allosteric Gating Mechanism." Journal of General Physiology 116, no. 1 (2000): 75–100. http://dx.doi.org/10.1085/jgp.116.1.75.

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The voltage- and Ca2+-dependent gating mechanism of large-conductance Ca2+-activated K+ (BK) channels from cultured rat skeletal muscle was studied using single-channel analysis. Channel open probability (Po) increased with depolarization, as determined by limiting slope measurements (11 mV per e-fold change in Po; effective gating charge, qeff, of 2.3 ± 0.6 eo). Estimates of qeff were little changed for intracellular Ca2+ (Ca2+i) ranging from 0.0003 to 1,024 μM. Increasing Ca2+i from 0.03 to 1,024 μM shifted the voltage for half maximal activation (V1/2) 175 mV in the hyperpolarizing directio
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Saeki, Toshiaki, Tadashi Nomizu, Masakazu Toi, et al. "Dofequidar Fumarate (MS-209) in Combination With Cyclophosphamide, Doxorubicin, and Fluorouracil for Patients With Advanced or Recurrent Breast Cancer." Journal of Clinical Oncology 25, no. 4 (2007): 411–17. http://dx.doi.org/10.1200/jco.2006.08.1646.

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Purpose To evaluate the efficacy and tolerability of dofequidar plus cyclophosphamide, doxorubicin, and fluorouracil (CAF) therapy in comparison with CAF alone, in patients with advanced or recurrent breast cancer. Dofequidar is a novel, orally active quinoline derivative that reverses multidrug resistance. Patients and Methods In this randomized, double-blind, placebo-controlled trial, patients were treated with six cycles of CAF therapy: 28 days/cycle, with doxorubicin (25 mg/m2) and fluorouracil (500 mg/m2) administered on days 1 and 8 and cyclophosphamide (100 mg orally [PO]) administered
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Reeves, W. B., and R. W. Gurich. "Calcium-dependent chloride channels in endosomes from rabbit kidney cortex." American Journal of Physiology-Cell Physiology 266, no. 3 (1994): C741—C750. http://dx.doi.org/10.1152/ajpcell.1994.266.3.c741.

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Ion channels in endosomal membranes from rabbit kidney cortex were studied after reconstitution into planar lipid bilayers. The most frequently observed ion channel was anion selective (PCl/PK = 13) and had a single-channel conductance of 116 pS when the cis and trans solutions contained 410 and 150 mM KCl, respectively, and a conductance of 90 pS in symmetrical 150 mM KCl solutions. The anion selectivity sequence of the channel was NO3- > F- > Br- > Cl- >> I-. The activity of the channel was voltage dependent such that hyperpolarization of the cis, or cytoplasmic, surface of th
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Chen, Ren-Shiang, Yanyan Geng, and Karl L. Magleby. "Mg2+ binding to open and closed states can activate BK channels provided that the voltage sensors are elevated." Journal of General Physiology 138, no. 6 (2011): 593–607. http://dx.doi.org/10.1085/jgp.201110707.

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BK channels are activated by intracellular Ca2+ and Mg2+ as well as by depolarization. Such activation is possible because each of the four subunits has two high-affinity Ca2+ sites, one low-affinity Mg2+ site, and a voltage sensor. This study further investigates the mechanism of Mg2+ activation by using single-channel recording to determine separately the action of Mg2+ on the open and closed states of the channel. To limit Mg2+ action to the Mg2+ sites, the two high-affinity Ca2+ sites are disabled by mutation. When the voltage is stepped from negative holding potentials to +100 mV, we find
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Ho, Alan L., Douglas R. Adkins, Jochen Lorch, Jacob S. Thomas, and Jaspreet S. Grewal. "Abstract PO-007: A phase 2 open-label study of conditionally active biologic, ozuriftamab vedotin (BA3021) in PD-1/L1 failure patients with recurrent or metastatic squamous cell carcinoma of the head and neck." Clinical Cancer Research 29, no. 18_Supplement (2023): PO—007—PO—007. http://dx.doi.org/10.1158/1557-3265.aacrahns23-po-007.

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Abstract Background: Ozuriftamab vedotin (BA3021) is a conditionally active biologic (CAB) anti-receptor tyrosine kinase orphan receptor 2 (ROR2) humanized monoclonal antibody (IgG1) conjugated to monomethyl auristatin E (MMAE) using a cleavable linker (CAB ROR2 ADC) (Short, et al., 2014, Chang, et al. 2021). Conditional and reversible binding by CABs is designed to reduce off-tumor toxicity and immunogenicity, avoid tissue-mediated drug deposition, and improve pharmacokinetics (PK). ROR2 is a cell-surface transmembrane receptor protein tyrosine kinase highly expressed in several tumor types i
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Fassinou, Nonvignon Martial, Fadéby Modeste Gouissi, Souradjou Orou Goura, et al. "Impacts de la Contamination Agricole sur la Qualité Physicochimique des Eaux de Surface de l’Ouémé Supérieur au Bénin." European Scientific Journal, ESJ 19, no. 9 (2023): 102. http://dx.doi.org/10.19044/esj.2023.v19n9p102.

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Le présent travail vise à apprécier la qualité physico-chimique des eaux de l’Ouémé supérieur au Bénin. L’étude concerne quatre (04) communes. Les données ont été collectées en octobre 2021 et en mars 2022. Les paramètres physiques in-situ et les paramètres chimiques au laboratoire ont été étudiés. La description par les box plots (Boîtes à moustaches), le test de Shapiro-Wilk et celui de Kruskall Wallis au seuil α = 5% ont été utilisés. Les paramètres tels la salinité, T°C,〖 NO〗_2^-, NO_3^-, NH_4^+, PO_4^(3-), Ca2+, Mg2+, Fe2+ et le Cl- sont significativement différents des autres paramètres
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Gil, Adam. "Ograniczenia współczesnych generatorów obrazów opartych o AI w procesie projektowania architektonicznego." BUILDER 320, no. 3 (2024): 28–33. http://dx.doi.org/10.5604/01.3001.0054.3459.

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Wraz z wprowadzeniem narzędzi CAD, a potem BIM, architekci zaczęli dostrzegać, że narzędzia, których używają, mają wpływ na ich twórczość. Obecnie architekci zaczynają używać narzędzi AI umożliwiających eksplorację koncepcji projektowych poprzez generowanie obrazów. Te narzędzia, zwane generatorami obrazów AI, generują obrazy na podstawie opisów tekstowych oraz dowolnych wczytanych obrazów, w tym szkiców lub zdjęć. Na rynku dostępne są zarówno narzędzia przeznaczone bezpośrednio do projektowania architektonicznego, jak i narzędzia o charakterze ogólnym, służące do generowania dowolnych obrazów
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Perrone, R., P. Vadhana Ashok Kumaar, K. Gore, J. Favret, E. Verdin, and S. Felstead. "POS1022 A NEWLY DEVELOPED SMALL MOLECULE CD38 INHIBITOR EXERTS THERAPEUTIC EFFECTS IN A COLLAGEN-INDUCED ARTHRITIS MOUSE MODEL." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 828.1–828. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5084.

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BackgroundCD38 is a NAD+ consuming enzyme ubiquitously expressed on immune cells and its expression increases in several pathological conditions, including Rheumatoid Arthritis (RA) [1, 2]. Pre-clinical studies in CD38knock-outmodels have demonstrated that CD38 deficient animals develop an attenuated form of Collagen-Induced-Arthritis (CIA) characterized by reduced inflammation and damage at the joint level suggesting a causal role of CD38 in the pathogenesis of CIA and, potentially, RA [3-5].ObjectivesThis study investigated the efficacy of NTX-748, a newly developed, potent and orally availa
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Masuda, Muneyuki, Hirofumi Omori, Kuniaki Sato, Josef Penninger, and Silvio Gutkind. "Abstract PO-063: Environment-induced YAP1 transcriptional reprogramming drives head and neck cancer." Clinical Cancer Research 29, no. 18_Supplement (2023): PO—063—PO—063. http://dx.doi.org/10.1158/1557-3265.aacrahns23-po-063.

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Abstract Background: The biology of head and neck cancer (HNC) has been explained by the field carcinogenesis theory in which accumulated abnormalities (mainly gene mutations) caused by environmental stresses promote carcinogenesis. However, as clearly demonstrated by recent studies (Yokoyama et.al, Nature 2019; Hedberg et.al, JCI 2016), the genetic landscape of HNC (i.e., the loss-of-function mutations in tumor suppressor genes) fails to account for the onset and metastatic ability of HNC. In addition to being mutagen, environmental stresses induce oncogenic transcriptional programs (e.g., ti
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Books on the topic "CAS PO 223"

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Tories, Unionists and Conservatives 1815-1914. Hodder Headline, 2002.

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Young, Michael, Kate Gavron, and Geoff Dench. The New East End: Kinship, Race and Conflict. Profile Books, 2006.

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New East End: Kinship, Race and Conflict. Profile Books Limited, 2007.

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NEW EAST END: KINSHIP, RACE AND CONFLICT. PROFILE, 2009.

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Book chapters on the topic "CAS PO 223"

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Elmerrahi, Mohamed. "La poésie en classe de FLE dans le contexte marocain : pour une approche culturelle et didactique axée sur le résultat, cas du (Tronc commun)." In Aux carrefours de la langue, de la littérature, de la didactique et de la société : la recherche francophone en action. Observatoire européen du plurilinguisme, 2021. http://dx.doi.org/10.3917/oep.agbef.2021.01.0271.

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Dans cet article, nous nous sommes interrogés sur les causes de l’impertinence de l’enseignement de la poésie en classe de français langue étrangère sur le plan social, dans un système éducatif qui privilégie l’individualisme (Donnat, 2004, p. 98) et le formalisme comme approche qui prône l’objectivité aux dépens de la subjectivité du sujet lecteur. Ce constat nous pousse à se demander laquelle des approches serait la plus appropr
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Della Valle, Paola. "Chapter 18 - Transmedia Environmental Poetry in the Pacific: Between Literature and the New Media." In Reframing Souths. Milano University Press, 2025. https://doi.org/10.54103/milanoup.213.c421.

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Poetry is a major artistic expression in the Pacific, due to a longstanding tradition of indigenous oral literature. In the present climate emergency, “po- et-performers” or “spoken word artists” have risen in this geographic area as militant figures that compose poetry and act it out on websites, in videos, during public performances and in important political venues. Pacific poets trespass the boundaries of a single medium and genre, mixing narratives, poetry, mu- sic, acting, photographs, videos, and paintings. They have created a transmedia form of art, in which integrated elements of a na
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Blagojević, Filip. "Slučaj „Kolubara” : Evolucija ili odstupanje u disciplinskoj praksi FSS?" In Srpski fudbal - uporednopravni izazovi i perspektive IV. Institut za uporedno pravo, 2024. https://doi.org/10.56461/zr_24.sf.02.

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U ovom radu autor analizira pravnu prirodu UEFA prijava koje se odnose na potencijalno nameštanje utakmica i koje predstavljaju okidač za pokretanje disciplinskih postupaka pred nacionalnim fudbalskim savezima, uz kratak osvrt na praksu Sportskog arbitražnog suda u Lozani (CAS) i regulativu Fudbalskog saveza Srbije. Posebna pažnja posvećena je pravnoj normi iz člana 83. Disci-plinskog pravilnika Fudbalskog saveza Srbije, koja, između ostalog, reguliše dis-ciplinske prekršaje ugrožavanja i povrede integriteta fudbalskih utakmica. Ova norma, koja je pretrpela najviše izmena i dopuna od njenog uv
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Esso, Lasm constant. "Les noms devises comme actes de langage chez les odjoukrou." In Aux carrefours de la langue, de la littérature, de la didactique et de la société : la recherche francophone en action. Observatoire européen du plurilinguisme, 2021. http://dx.doi.org/10.3917/oep.agbef.2021.01.0139.

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Dans les sociétés dites orales à l’instar de celles des cultures négro-africaines traditionnelles, la communication ne s’effectue pas toujours au moyen de la parole nue. Elle prend toutes les formes du langage et se véhicule en certaines circonstances par le biais de médias comme le tambour, l’olifant etc. Ce langage transcodé met toujours en exergue la fonction performative des discours littéraires que sont entre autres la devise, le proverbe, le chant, la prière etc. En effet, chez
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Conference papers on the topic "CAS PO 223"

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Hosseini, Hadi, Aghaheybat Mammadov, and Tomasz Wąs. "Fairly Allocating Goods and (Terrible) Chores." In Thirty-Second International Joint Conference on Artificial Intelligence {IJCAI-23}. International Joint Conferences on Artificial Intelligence Organization, 2023. http://dx.doi.org/10.24963/ijcai.2023/305.

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We study the fair allocation of mixture of indivisible goods and chores under lexicographic preferences---a subdomain of additive preferences. A prominent fairness notion for allocating indivisible items is envy-freeness up to any item (EFX). Yet, its existence and computation has remained a notable open problem. By identifying a class of instances with "terrible chores", we show that determining the existence of an EFX allocation is NP-complete. This result immediately implies the intractability of EFX under additive preferences. Nonetheless, we propose a natural subclass of lexicographic pre
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Fučka, Matic, Marko Rus, Jakob Božič, and Danijel Skočaj. "Generiranje sintetičnih slik iz 3D modelov predmetov za učenje segmentacijskih modelov v industrijskem okolju." In ROSUS 2023 - Računalniška obdelava slik in njena uporaba v Sloveniji 2023. Univerza v Mariboru, Univerzitetna založba, 2023. http://dx.doi.org/10.18690/um.feri.4.2023.9.

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Ena večjih preprek uporabe globokega učenja v industriji je zahteva po velikem številu označenih slik potrebnih za nadzorovano učenje. Ker je pridobivanje označenih slik pogosto zamuden in drag proces, se veliko metod skuša izogniti temu problemu z bogatenjem učnih slik, ki so na voljo, ali z uporabo sintetičnih slik za predhodno učenje in poznejše doučenje z resničnimi slikami. V tem članku predlagamo metodo za generiranje sintetičnih slik iz danih 3D CAD modelov in novo podatkovno množico sestavljeno iz sintetičnih in resničnih slik ter njihovih segmentacijskih slik. Obravnavamo torej scenar
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Magri, Luca, Luigi Sequino, and Cristian Ferrari. "Advantages of 3d and 1d Modeling a Li-Po Battery for the Prediction of Overheating under Real Driving Conditions." In 16th International Conference on Engines & Vehicles. SAE International, 2023. http://dx.doi.org/10.4271/2023-24-0167.

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<div class="section abstract"><div class="htmlview paragraph">1d multi-domain modeling is a powerful tool for the fast prototyping of battery packs for electric vehicles. It can help identify the optimal layout for structural and thermal aspects and then support the battery sizing process. On the other hand, its simplicity may fail whereas precise simulations are needed. For example, a catastrophic event such as the thermal runaway can be triggered by a local peak of temperature on a single cell of the battery pack and then spread to the others. For this reason, the surface tempera
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Abdul Nasar, Rafath, and Mohammad A. Al-Shudeifat. "Employing Machine Learning to Detect Post Resonance Backward Whirl in a Faulty Rotor System." In ASME 2023 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/imece2023-116335.

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Abstract Machine Learning (ML) algorithms have several applications in various fields of science. One of the major applications of ML is to recognize patterns in input signals and classify the input accordingly to various classes. Employing ML with structural health monitoring tools to identify faults has become an emerging area in research. Faults in rotor systems generally cause asymmetries in the rotor shaft stiffness which further results in generating higher harmonic components. One of the recent tools that has been prevalently used to identify faults is the post-resonance backward whirl
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Floares, Doris, Diana Obistioiu, Anca Hulea, Ersilia Alexa, and Isidora Radulov. "THUJA OCCIDENTALIS AND PLATYCLADUS ORIENTALIS ANTIMICROBIAL ACTIVITY." In 23rd SGEM International Multidisciplinary Scientific GeoConference 2023. STEF92 Technology, 2023. http://dx.doi.org/10.5593/sgem2023v/6.2/s25.57.

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The rise of bacterial resistance to currently employed antibiotics is causing growing concerns for public health. The emergence of highly resistant bacterial strains results in the ineffectiveness of antibiotic treatments against many bacterial infections. As a result, there is an ongoing quest for new antimicrobial agents. This pursuit can take two main directions: one involves the design and synthesis of novel agents, while the other involves exploring natural sources to uncover previously undiscovered antimicrobial compounds. Herbal medications, particularly, have garnered renewed interest
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Li, Yiduo, Shiyi Qi, Zhe Li, Zhongwen Rao, Lujia Pan, and Zenglin Xu. "SMARTformer: Semi-Autoregressive Transformer with Efficient Integrated Window Attention for Long Time Series Forecasting." In Thirty-Second International Joint Conference on Artificial Intelligence {IJCAI-23}. International Joint Conferences on Artificial Intelligence Organization, 2023. http://dx.doi.org/10.24963/ijcai.2023/241.

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The success of Transformers in long time series forecasting (LTSF) can be attributed to their attention mechanisms and non-autoregressive (NAR) decoder structures, which capture long-range de- pendencies. However, time series data also contain abundant local temporal dependencies, which are often overlooked in the literature and significantly hinder forecasting performance. To address this issue, we introduce SMARTformer, which stands for SeMi-AutoRegressive Transformer. SMARTformer utilizes the Integrated Window Attention (IWA) and Semi-AutoRegressive (SAR) Decoder to capture global and local
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Stojanović, Željko, Milan Jovanović, and Asen Radovanov. "ANALIZA STANJA ELEMENATA PRENOSNE MREŽE PO OSNOVU PROBLEMATIKE UVEĆANIH VREDNOSTI STRUJA KRATKIH SPOJEVA I NJIHOV UTICAJ NA OPREMU U POTROJENJIMA." In 36. Savetovanja CIGRE Srbija 2023 Fleksibilnost elektroenergetskog sistema. Srpski nacionalni komitet Međunarodnog saveta za velike električne mreže CIGRE Srbija, 2023. http://dx.doi.org/10.46793/cigre36.0693s.

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The task of the analysis in question is to look at the problem and show what impact the new switching conditions in the operation of individual transformer stations have on the energy equipment in transformer stations and transmission lines. Examples that have been done include impacting: High power circuit breakers: This analysis is based on guaranteed values by the circuit breaker manufacturer. The dependence of the sum of the number of permitted interruptions n on the interruption current i is shown. On the basis of which calculations were made, from which it is clearly seen that a lower br
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Toksanbayev, N. K., and A. C. Adoko. "An Optimized Deep Neural Network for Rockburst Damage Potential Modelling." In 57th U.S. Rock Mechanics/Geomechanics Symposium. ARMA, 2023. http://dx.doi.org/10.56952/arma-2023-0905.

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ABSTRACT Managing ground prone to rockburst is challenging, especially in seismically active underground mines. Over the past few decades, numerous studies have been conducted on predicting rockburst damage potential. However, in most cases, only fair model performance was achieved due to the complex nature of rockburst as a seismic event and the non-linearity of data. To overcome these limitations, this paper presents a more reliable model for predicting rockburst damage potential (RDP). An Artificial Neural Network was established, and its parameters were optimized using the Adam optimizer.
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Ruginytė, Kristina Ruginytė, and Anatolijus Eisinas. "Sintetinio majenito adsorbcinės savybės vario jonams." In 23-oji jaunųjų mokslininkų konferencijos „Mokslas – Lietuvos ateitis“ teminė konferencija APLINKOS APSAUGOS INŽINERIJA. Vilnius Gediminas Technical University, 2020. http://dx.doi.org/10.3846/aainz.2020.011.

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Šio darbo tikslas yra ištirti vario jonų koncentracijos įtaką sintetinio majenito adsorbcinei gebai. Nustatyta, kad CaO-Al2O3-H2O sistemoje hidroterminės sintezės metu susidaro majenito prekursorius – katoitas bei lieka nedidelis kiekis portlandito. Antrajame sintezės etape katoitas buvo išdegtas 1 h 900 °C temperatūroje, kurioje jis visiškai suskyla ir susidaro majenitas, šio proceso metu identifikuotas ir portlandito skilimo produktas CaO. Nustatyta, kad 900 °C tem-peratūroje degto produkto paviršiaus plotas lygus 24,55 m2/g. Ištirta, kad bandinio porų paviršiuje susidaro stabilus ad-sorbuot
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