Relevant bibliographies by topics / Cationic Vector

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  2. Dissertations / Theses
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Academic literature on the topic 'Cationic Vector'

Author: Grafiati
Published: 7 July 2024
Last updated: 31 July 2025

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Journal articles on the topic "Cationic Vector"

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TAN, AMELIA LI MIN, ALISA XUE LING LIM, YITING ZHU, YI YAN YANG, and MAJAD KHAN. "CATIONIC BOLAAMPHIPHILES FOR GENE DELIVERY." COSMOS 10, no. 01 (2014): 25–38. http://dx.doi.org/10.1142/s0219607714400059.

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Advances in medical research have shed light on the genetic cause of many human diseases. Gene therapy is a promising approach which can be used to deliver therapeutic genes to treat genetic diseases at its most fundamental level. In general, nonviral vectors are preferred due to reduced risk of immune response, but they are also commonly associated with low transfection efficiency and high cytotoxicity. In contrast to viral vectors, nonviral vectors do not have a natural mechanism to overcome extra- and intracellular barriers when delivering the therapeutic gene into cell. Hence, its design h
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Bengali, Zain, and Lonnie D. Shea. "Gene Delivery by Immobilization to Cell-Adhesive Substrates." MRS Bulletin 30, no. 9 (2005): 659–62. http://dx.doi.org/10.1557/mrs2005.193.

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AbstractBiomaterials can potentially enhance the delivery of viral and nonviral vectors for both basic science and clinical applications.Vectors typically consist of nucleic acids (DNA, RNA) packaged with proteins, lipids, or cationic polymers, which facilitate cellular internalization and trafficking. These vectors can associate with biomaterials that support cell adhesion, a process we term substrate-mediated delivery. Substrate immobilization localizes the DNA and the delivery vector to the cellular microenvironment.The interaction between the vector and substrate must be appropriately bala
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Nakayama, Yasuhide, Takeshi Masuda, Makoto Nagaishi, Michiko Hayashi, Moto Ohira, and Mariko Harada-Shiba. "High Performance Gene Delivery Polymeric Vector: Nano-Structured Cationic Star Polymers (Star Vectors)." Current Drug Delivery 2, no. 1 (2005): 53–57. http://dx.doi.org/10.2174/1567201052772825.

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Porter, Colin D., Katalin V. Lukacs, Gary Box, Yasuhiro Takeuchi, and Mary K. L. Collins. "Cationic Liposomes Enhance the Rate of Transduction by a Recombinant Retroviral Vector In Vitro and In Vivo." Journal of Virology 72, no. 6 (1998): 4832–40. http://dx.doi.org/10.1128/jvi.72.6.4832-4840.1998.

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ABSTRACT Cationic liposomes enhanced the rate of transduction of target cells with retroviral vectors. The greatest effect was seen with the formulation DC-Chol/DOPE, which gave a 20-fold increase in initial transduction rate. This allowed an efficiency of transduction after brief exposure of target cells to virus plus liposome that could be achieved only after extensive exposure to virus alone. Enhancement with DC-Chol/DOPE was optimal when stable virion-liposome complexes were preformed. The transduction rate for complexed virus, as for virus used alone or with the polycation Polybrene, show
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Guo, Man, Yingcai Meng, Xiaoqun Qin та Wenhu Zhou. "Dopamine-Grafted Hyaluronic Acid Coated Hyperbranched Poly(β-Amino Esters)/DNA Nano-Complexes for Enhanced Gene Delivery and Biosafety". Crystals 11, № 4 (2021): 347. http://dx.doi.org/10.3390/cryst11040347.

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Gene therapy has attracted particular attention for the treatment of various genetic diseases, and the development of gene delivery vectors is of utmost importance for in vivo applications of gene drugs. Various cationic polymers with high nucleic acid loading and intracellular transfection efficiency have been reported, however, their biological applications are limited by potential toxicity. Surface modification is a robust solution to detoxify the cationic vectors, but this can inevitably weaken the transfection efficiency. To address this dilemma, we reported the ability of a dopamine (DA)
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Marquet, Franck, Viorica Patrulea та Gerrit Borchard. "Comparison of triblock copolymeric micelles based on α- and ε-poly(L-lysine): a Cornelian choice". Polymer Journal 54, № 2 (2021): 199–209. http://dx.doi.org/10.1038/s41428-021-00552-5.

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AbstractDue to the lack of safe carriers for the delivery of small interfering RNA (siRNA), clinical applications of nucleotide-based therapeutics have been limited. In this study, biodegradable amphiphilic triblock copolymers with tailored molecular weights for each block composed of methoxy poly(ethylene glycol) (2000 g/mol), poly(L-lysine) (1300 g/mol) and poly(D,L-lactic acid) (1800 g/mol) (mPEG45-α-PLL10-PLA25) were synthesized and fully characterized. The peptide synthesis was carried out on a solid phase to limit the presence of cationic charges. The arrangement and availability of cati
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El-Mahdy, Ahmed F. M., Takayuki Shibata, Tsutomu Kabashima, Qinchang Zhu, and Masaaki Kai. "Delivery of siRNA using siRNA/cationic vector complexes encapsulated in dendrimer-like polymeric DNAs." RSC Advances 5, no. 41 (2015): 32775–85. http://dx.doi.org/10.1039/c5ra01032b.

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Berchel, Mathieu, Tony Le Gall, Olivier Lozach, Jean-Pierre Haelters, Tristan Montier, and Paul-Alain Jaffrès. "Lipophosphoramidate-based bipolar amphiphiles: their syntheses and transfection properties." Organic & Biomolecular Chemistry 14, no. 10 (2016): 2846–53. http://dx.doi.org/10.1039/c5ob02512e.

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Budker, Vladimir, Vladimir Gurevich, James E. Hagstrom, Fedor Bortzov, and Jon A. Wolff. "pH-sensitive, cationic liposomes: A new synthetic virus-like vector." Nature Biotechnology 14, no. 6 (1996): 760–64. http://dx.doi.org/10.1038/nbt0696-760.

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Ito, Akira, Tetsuya Takahashi, Yujiro Kameyama, Yoshinori Kawabe, and Masamichi Kamihira. "Magnetic Concentration of a Retroviral Vector Using Magnetite Cationic Liposomes." Tissue Engineering Part C: Methods 15, no. 1 (2009): 57–64. http://dx.doi.org/10.1089/ten.tec.2008.0275.

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Dissertations / Theses on the topic "Cationic Vector"

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Nouveau, Thibaut. "Nébulisation de nouveaux polyplexes pour le transfert de gènes." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS734.pdf.

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La thérapie génique est une forme de thérapie pour traiter les maladies génétiques héréditaires ou acquises tels que les cancers ou la mucoviscidose. L’introduction d’un polynucléotide, par voie systémique ou locale (orale ou nasale par exemple), au sein des cellules malades permet de corriger les défauts à l’origine des mutations génétiques. Néanmoins, le franchissement des différentes barrières biologiques nécessaire à l’internalisation de l’ADN ne peut se faire que par l’intermédiaire d’un vecteur qui va le protéger et lui permettre d’atteindre le noyau de la cellule où il sera transcrit. D
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Terp, Megan Cavanaugh. "Improved Nanoparticle Preparation and Delivery Technology for DOTAP and Oligonucleotide Based Lipoplexes." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338301430.

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Ho, J. K. W. "Synthesis and biophysical studies of cationic lipids as gene delivery vectors." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1389331/.

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Non–viral gene vectors exhibit several desirable properties, over their viral counterparts. This has generated vast interest in the development of efficient non–viral vectors for DNA in gene therapy. The first generation lipid/peptide/DNA (LID) vector was comprised of Lipofectin™, a 1:1 mixture of DOTMA and DOPE, together with a targeting peptide. The resulting LID vector exhibited significant advantages over cationic liposome vectors (lipoplex systems) for gene delivery, transfecting a range of cells with high transfection efficiencies. The LID vector is introduced, and its advantages are out
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Mohammadi, A. "Design and development of tuneable cationic lipopolyplexes as vectors in gene therapy." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1389064/.

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Gene therapy is a promising technique that offers great potential for the treatment of inherited and acquired disorders. However, one of the major obstacles is identifying suitable vectors with high targeting and transfection efficiency. A literature review on gene therapy and studies on the developments of vectors in gene therapy is presented in Chapter 1. The results and discussion for the development of novel targeting peptides is outlined in Chapter 2. Biophysical analyses of the peptides were performed in PD (peptide-DNA) and LPD (lipid-peptide-DNA) formulations, and found to be stable ov
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Belmadi, Nawal. "Développement, formulation et biodistribution de vecteurs synthétiques pour le transfert de gènes dans le cadre de la thérapie génique de la mucoviscidose." Thesis, Brest, 2015. http://www.theses.fr/2015BRES0093/document.

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La mucoviscidose est une maladie monogénique, caractérisée par des mutations survenant au niveau du gène CFTR (Cystic Fibrosis Transmembrane Conductance Regulator). Le clonage en 1989 du gène CFTR a permis d’envisager de traiter cette maladie par thérapie génique. Cela consiste à transférer à l’aide d’un vecteur, une version normale du gène CFTR dans les cellules atteintes des patients. En raison de la gravité des complications pulmonaires, c’est l’épithélium respiratoire qui constitue aujourd’hui le tissu cible pour le transfert de gènes. Le principe de la thérapie génique est évidemment très
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Cruz, Claudemir Mota da. "Estudo dos campos vetoriais polinomiais quadráticos que possuem integral primeira racional de grau 3." Universidade Federal da Paraí­ba, 2011. http://tede.biblioteca.ufpb.br:8080/handle/tede/7354.

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Made available in DSpace on 2015-05-15T11:46:00Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 3489954 bytes, checksum: 857373bbfa0d1a2ba6e371f0fab25e09 (MD5) Previous issue date: 2011-04-18<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>This work was dedicated to classify all the global phase portraits of the quadratic polynomial vector fields having a rational first integral of degree three. For this, techniques were used as blow-up, classification of singular points, invariant curves for a system of ordinary diferential equations and vector fields induced o
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Ver?ssimo, Lourena Mafra. "Desenvolvimento de nanosistemas farmac?uticos para terapia g?nica." Universidade Federal do Rio Grande do Norte, 2011. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12638.

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Made available in DSpace on 2014-12-17T14:05:18Z (GMT). No. of bitstreams: 1 LourenaMF_TESE_Capa_ate_pag79.pdf: 4572586 bytes, checksum: 2630047160ff526cc964f166fb86ab33 (MD5) Previous issue date: 2011-03-14<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>Gene therapy is one of the major challenges of the post-genomic research and it is based on the transfer of genetic material into a cell, tissue or organ in order to cure or improve the patient s clinical status. In general, gene therapy consists in the insertion of functional genes aiming substitute, complement or inhib
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Le, Bihan Olivier. "Etude par microscopie électronique des mécanismes d'action de vecteurs synthétiques pour le transfert de gènes." Thesis, Bordeaux 1, 2009. http://www.theses.fr/2009BOR13972/document.

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La grande majorité des essais cliniques de transfert de gènes in vivo utilise des vecteurs viraux. Si ces derniers sont efficaces, ils présentent des risques immunogènes, toxiques, voire mutagènes avérés. Les vecteurs synthétiques (non viraux), par leur grande modularité et leur faible toxicité représentent une alternative très prometteuse. Le principal frein à leur utilisation est leur manque d’efficacité. L’objectif majeur de ce travail de thèse a été de comprendre le mécanisme de transfert de gènes associé à différents complexes vecteurs synthétiques/ADN plasmidique, ce qui est indispensabl
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Feng, Tzu-Hua, and 馮子驊. "Synthesis and Characterization of Star-Shaped Cationic Copolymer Hybrid Micelles as a Gene Vector." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/52853289244065649927.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>100<br>In this study, amphiphilic star-shaped cationic copolymers were synthesized of hydrophobic monomer and hydrophilic cationic monomer. The synthesized polymer was determined by 1H-NMR spectroscopy and gel permeation chromatography (GPC). The synthesized star-shaped cationic copolymer micelles and hybrid micelles contained PEG are formed by oil-in-water solvent evaporation method. The polyplex binding ability, transfection efficiency and cytotoxicity of micelles are all compared by gel electrophoresis performance, luciferase assay and MTT assay.
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Lee, Chien Hsing, and 李建興. "THE STUDY OF POLYCATIONS AND CATIONIC LIPOSOMES AS A NON-VIRAL VECTOR FOR GENE DELIVERY." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/67776008321623946734.

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博士<br>國立臺灣大學<br>生物化學暨分子生物學研究所<br>91<br>During the past years, non-viral gene delivery vector was emerging as a new modality as well as a technology in laboratory and in medical practice. A promising area of research is the design of targeted lipid-DNA complexes. It is clear that the physicochemical properties of lipid-DNA complexes are very important in the design of the ideal lipidic vector. The requirements for such an ideal vector can be summarized as follows: (1) the particles should be small enough to be taken up by organs and surface protected by polyethylene glycol (PEG), to avoid pr
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Book chapters on the topic "Cationic Vector"

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Jubeli, Emile, William P. D. Goldring, and Michael D. Pungente. "Cationic Lipid-Based Nucleic Acid Vectors." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3718-9_2.

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Sherly, M. Caroline Diana, S. S. Priya, and M. R. Rekha. "Cationic Polyelectrolyte Vectors in Gene Delivery." In Particulate Technology for Delivery of Therapeutics. Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-3647-7_12.

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Falsini, Sara, and Sandra Ristori. "Lipoplexes from Non-viral Cationic Vectors: DOTAP-DOPE Liposomes and Gemini Micelles." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3718-9_3.

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Flechsler, Insa, A. Surovoy, K. Charissé, E. Bayer, and G. Jung. "Comparison of Antisense Vectors and Antisense Oligonucleotides Delivered by Means of the New Cationic Lipids Unifectin and Maxifectin." In Advances in Experimental Medicine and Biology. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5357-1_72.

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Arruda, Danielle Campiol, Anne Schlegel, Pascal Bigey, and Virginie Escriou. "Lipoplexes Strengthened by Anionic Polymers: Easy Preparation of Highly Effective siRNA Vectors Based on Cationic Lipids and Anionic Polymers." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3718-9_8.

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Zahid, Maliha, Xiaoli Lu, Zhibao Mi, and Paul D. Robbins. "Cationic and Tissue-Specific Protein Transduction Domains." In Tissue-Specific Vascular Endothelial Signals and Vector Targeting, Part B. Elsevier, 2010. http://dx.doi.org/10.1016/s0065-2660(10)69007-4.

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Bulbake, Upendra, Anjali Jain, and Wahid Khan. "Nanocarriers as Non-Viral Vectors in Gene Delivery Application." In Multifunctional Nanocarriers for Contemporary Healthcare Applications. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-4781-5.ch013.

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Gene therapy is the emerging trend in biomedical science for treatment of life-threatening diseases. This involves delivery of a therapeutic gene to the nucleus of an affected cell by a suitable vector. Gene delivery using non-viral vectors such as cationic polymer and lipid is gaining attention due to their favourable properties, including lack of immunogenicity, low toxicity, and potential for tissue specificity when compared with viral vectors. A variety of non-viral vectors have been proposed, most of which facilitate gene delivery by electrostatic interactions, encapsulation, and in some
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"Nomenclature and Classifi cation." In Plant Virus, Vector. CRC Press, 2010. http://dx.doi.org/10.1201/9780429196409-6.

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Fang, Yang, and Ke Zhang. "Cationic vs. non-cationic polymeric vectors for nucleic acid delivery." In Reference Module in Materials Science and Materials Engineering. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-822425-0.00024-5.

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Marshall, John, Nelson S. Yew, Simon J. Eastman, Canwen Jiang, Ronald K. Scheule, and Seng H. Cheng. "Cationic Lipid-Mediated Gene Delivery to the Airways." In Nonviral Vectors for Gene Therapy. Elsevier, 1999. http://dx.doi.org/10.1016/b978-012358465-6/50015-3.

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Conference papers on the topic "Cationic Vector"

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Ito, Akira, Tetsuya Takahashi, Yujiro Kameyama, Yoshinori Kawabe, and Masamichi Kamihira. "Magnetic Manipulation of a Retroviral Vector Using Magnetite Cationic Liposomes." In 2008 International Symposium on Micro-NanoMechatronics and Human Science (MHS). IEEE, 2008. http://dx.doi.org/10.1109/mhs.2008.4752479.

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Naruki, M., H. En’yo, R. Muto, et al. "Medium Modi cation on Vector Mesons Observed in 12 GeV p + A Reactions." In INTERSECTIONS OF PARTICLE AND NUCLEAR PHYSICS: 9th Conference CIPAN2006. AIP, 2006. http://dx.doi.org/10.1063/1.2402687.

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Reports on the topic "Cationic Vector"

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Ohad, Itzhak, and Himadri Pakrasi. Role of Cytochrome B559 in Photoinhibition. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7613031.bard.

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The aim of this research project was to obtain information on the role of the cytochrome b559 in the function of Photosystem-II (PSII) with special emphasis on the light induced photo inactivation of PSII and turnover of the photochemical reaction center II protein subunit RCII-D1. The major goals of this project were: 1) Isolation and sequencing of the Chlamydomonas chloroplast psbE and psbF genes encoding the cytochrome b559 a and b subunits respectively; 2) Generation of site directed mutants and testing the effect of such mutation on the function of PSII under various light conditions; 3)
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