Academic literature on the topic 'Cd40lg-'

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Journal articles on the topic "Cd40lg-"

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Hubbard, Nicholas, David Hagin, Karen Sommer, et al. "Targeted gene editing restores regulated CD40L function in X-linked hyper-IgM syndrome." Blood 127, no. 21 (2016): 2513–22. http://dx.doi.org/10.1182/blood-2015-11-683235.

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Key PointsThe CD40LG locus can be specifically targeted and repaired in primary human T cells by insertion of a spliced CD40LG complementary DNA. Gene editing restores regulated CD40L expression in X-HIGM T cells, reconstituting B-cell immunoglobulin class switching.
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Hubbard, Nicholas Wesley, David Hagin, Karen Sommer, et al. "Targeted Gene Editing Restores Regulated CD40L Expression and Function in X-HIGM T cells." Journal of Immunology 196, no. 1_Supplement (2016): 214.28. http://dx.doi.org/10.4049/jimmunol.196.supp.214.28.

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Abstract Loss of CD40L expression or function results in X-Linked Hyper-IgM Syndrome (X-HIGM), characterized by recurrent infections due to impaired immunoglobulin class-switching and somatic hypermutation. Previous attempts using retroviral gene transfer to correct murine CD40L expression restored immune function; however, treated mice developed lymphoproliferative disease, likely due to viral-promoter dependent constitutive CD40L expression. These observations highlight the importance of preserving endogenous gene regulation in order to safely correct this disorder. Here we report efficient,
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Kutukculer, Necil, Neslihan Edeer Karaca, Guzide Aksu, Ayca Aykut, Erhan Pariltay, and Ozgur Cogulu. "An X-Linked Hyper-IgM Patient Followed Successfully for 23 Years without Hematopoietic Stem Cell Transplantation." Case Reports in Immunology 2018 (October 14, 2018): 1–4. http://dx.doi.org/10.1155/2018/6897935.

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When caring for patients with life-limiting diseases, improving survival and optimizing quality of life are the primary goals. For patients with X-linked hyper-IgM syndrome (XHIGM), the treatment modality has to be decided for a particular patient regarding hematopoietic stem cell transplantation or intravenous immunoglobulin replacement therapy with P. jiroveci prophylaxis. A seven-year-old male patient was admitted with recurrent upper and lower respiratory tract infections and recurrent otitis media. His initial immunologic evaluation revealed low IgG and normal IgA and IgM levels with norm
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Kato, Kazunori, Yukari Masuta, Kei Tomihara, Katsunori Sasaki, and Hirofumi Hamada. "A Novel Non-Cleavable Cell Surface Mutant of CD40-Ligand Induces Anti-Leukemic Immune Response and Prevent Systemic Inflammatory Reaction." Blood 104, no. 11 (2004): 3174. http://dx.doi.org/10.1182/blood.v104.11.3174.3174.

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Abstract CD40-ligand (CD40L), a member of the TNF family, is expressed transiently on activated CD4-positive T cells and mediates cognate interaction between T cell and antigen-presenting cell (APC) such as dendritic cells. We and other investigators have reported previously that transduction of human leukemia cells with adenovirus encoding full-length CD40-ligand resulted in upregulation of immune costimulatory molecules, enhance APC activity and generation of CTL to leukemia B cells. However, CD40L is cleaved to a soluble form (sCD40L) by metalloproteases and high levels of sCD40L may contri
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Yeh, Yu-Min, Peng-Chan Lin, Wu-Chou Su, and Meng-Ru Shen. "CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c.1085 Genotypes." International Journal of Molecular Sciences 22, no. 22 (2021): 12565. http://dx.doi.org/10.3390/ijms222212565.

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Colony-stimulating factor 1 receptor (CSF-1R) acts as the receptor for colony stimulating factor 1, a cytokine that controls the production, differentiation, and function of macrophages. Prior studies showed cancer patients harboring germline CSF1R c.1085A>G genetic variant had better survival. Here, primary tumor samples from a stage III colorectal cancer (CRC) cohort were analyzed by a targeted gene expression assay containing 395 immune-related genes to study the immune mechanism underlying the different outcomes. CRC patients with CSF1R c.1085 genotype A_G had a better disease-free and
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Dong, Qiuting, Jinxia Zhao, Zhongqiang Yao, Xiangyuan Liu, and Huiying He. "A Case Report of X-Linked Hyperimmunoglobulin M Syndrome with Lipoma Arborescens of Knees." Case Reports in Medicine 2016 (2016): 1–4. http://dx.doi.org/10.1155/2016/5797232.

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The X-linked hyperimmunoglobulin M syndrome (HIGM), caused by mutations in the CD40LG gene, is a kind of primary immunodeficiency disease (PID). Patients with X-linked HIGM are susceptible to infection as well as autoimmune diseases. Lipoma arborescens (LA) is a rare benign tumor, of which the pathogenesis mechanism has not been clearly understood. We report a case of HIGM combined with LA in a 22-year-old male patient. A new deletion mutation of CD40LG gene was detected in this case. The possible relationship between HIGM and LA was also discussed.
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Rigaud, Stéphanie, Eduardo Lopez-Granados, Sophie Sibéril, et al. "Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG." Blood 118, no. 2 (2011): 252–61. http://dx.doi.org/10.1182/blood-2011-01-328849.

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Abstract The present study focuses on a large family with an X-linked immunodeficiency in which there are variable clinical and laboratory phenotypes, including recurrent viral and bacterial infections, hypogammaglobulinemia, Epstein-Barr virus–driven lymphoproliferation, splenomegaly, colitis, and liver disease. Molecular and genetic analyses revealed that affected males were carriers of a hypomorphic hemizygous mutation in XIAP (XIAPG466X) that cosegregated with a rare polymorphism in CD40LG (CD40 ligandG219R). These genes are involved in the X-linked lymphoproliferative syndrome 2 and the X
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Brune, Zarina, Bharati Matta, and Betsy Barnes. "IRF5 regulation of CD4+ T cell metabolism controls CD40L expression." Journal of Immunology 208, no. 1_Supplement (2022): 165.02. http://dx.doi.org/10.4049/jimmunol.208.supp.165.02.

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Abstract Systemic Lupus Erythematosus (SLE) is a devastating autoimmune disease that results from failure of the immune system to distinguish “self” from “non-self”. Studies in our lab and others demonstrated that human SLE CD4+ T cells have elevated levels of IRF5 and increased metabolism, while Irf5 knockout murine CD4+ T cells show diminished utilization of oxidative phosphorylation and glycolysis, respectively. However, how IRF5 contributes to CD4+ T cell support of B cell function and dysfunction has not been fully elucidated. Here, using IRF5 KO C57BL/6J mice, we show that loss of IRF5 i
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Horrillo, Angélica, Tomás Fontela, Elena G. Arias-Salgado, et al. "Generation of mice with conditional ablation of the Cd40lg gene: new insights on the role of CD40L." Transgenic Research 23, no. 1 (2013): 53–66. http://dx.doi.org/10.1007/s11248-013-9743-2.

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Shimoda, Michiko, Anna Bolduc, Mayuko Takezaki, Takeshi Tsubata, and Pandelakis Koni. "Excess B cell CD40/CD40L signaling promotes CD4 T cell-mediated encephalomyelitis in mice (44.22)." Journal of Immunology 186, no. 1_Supplement (2011): 44.22. http://dx.doi.org/10.4049/jimmunol.186.supp.44.22.

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Abstract To test the pathogenic role of B cells under excess inflammatory CD40/CD40L signaling, experimental autoimmune encephalomyelitis (EAE) was induced in B cell specific CD40L transgenic (CD40LBTg) and C57BL/6 control mice by immunization with MOG35-55 peptide. Clinical symptoms were monitored using a 0-5 scoring system during days 10-30 after induction. Alternatively, MOG-specific CD4 TCR Tg (2D2) mice were crossed onto a CD40LBTg background and the incidence of spontaneous encephalomyelitis monitored at 4-35 weeks of age. Both CD40LBTg and control mice developed EAE with similar kinetic
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Dissertations / Theses on the topic "Cd40lg-"

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MERCURI, ELISABETTA. "PRECLINICAL MODELING HIGHLIGHTS THE THERAPEUTIC POTENTIAL OF THE ADOPTIVE TRANSPLANT OF GENE CORRECTED T CELLS IN X-LINKED HYPER-IGM IMMUNODEFICIENCY." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2020. http://hdl.handle.net/10281/263922.

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La terapia genica di cellule staminali ematopoietiche (HSC) ha prodotto benefici clinici in diversi pazienti affetti da una varietà di malattie genetiche. Tuttavia, l’uso di vettori che si integrano nel genoma in modo semi-casuale pone il rischio di mutagenesi inserzionale e di una espressione del transgene ectopica/non regolata. Quest’ultimo problema è particolarmente rilevante quando si trattano geni strettamente regolati attivi sulla proliferazione cellulare, come il gene CD40LG, la cui espressione sulle cellule T attivate porta all’attivazione contatto-dipendente delle cellule B, alla loro
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Yeboah, Sybil A. Parise Leslie V. "Do CD40L and CD40 contribute to sickle cell anemia?" Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1640.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the degree of Master of Science in the Department of Biochemistry." Discipline: Biochemistry and Biophysics; Department/School: Medicine.
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Martins, Ryan Stephen. "Tumor-Bearing Host Macrophage Dysfunction: Role of CD40/CD40L Interactions." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/32405.

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A functional immune system is a potential barrier to tumor growth and progression. Cancer is caused, in part, by the loss of immune surveillance leading to the inability of the immune system to destroy the cancer cells. Macrophages (Mfs) are essential cellular components of the immune system; they influence immune responses in diverse and fundamental ways. As a consequence, Mfs present targets for tumors to evade, thereby enhancing tumor survival and growth. An interaction between CD40 on Mfs and CD40L on T cells is required for cell-mediated inflammatory responses. The CD40/CD40L interactio
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Oxer, Daniella Stefani. "Interação entre as vias de sinalização CD40/CD40L e os PPARs." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5159/tde-17062009-122735/.

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O receptor CD40 e seu ligante CD40L possuem um papel importante na interface entre a resposta imune inata e a adaptativa. Disfunções desta via de sinalização são descritas em doenças de origem inflamatória e autoimunes. Em Lúpus eritematoso sistêmico (LES) foi descrito um aumento nos níveis séricos de CD40L solúvel, que participa na produção de autoanticorpos. Receptores ativados por proliferadores de peroxisomos (PPARs) são fatores de transcrição que inicialmente foram descritos como envolvidos apenas no metabolismo lipídico, mas que atualmente são também descritos como atuantes no controle d
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Macina, Denis. "Étude de l'implication du système CD40/CD40L dans le syndrome hyper-IGM." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq33704.pdf.

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Morgenroth, Iris. "Charakterisierung des CD40-CD40L-Systems als wichtiger Regulator der B-Zellfunktion des Haushuhns." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-77513.

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Bürger, Christina [Verfasser], and Sabine [Akademischer Betreuer] Steffens. "Cell type-specific CD40-CD40L interaction in atherosclerosis / Christina Bürger ; Betreuer: Sabine Steffens." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1142787141/34.

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Pluvinet, Ortega Raquel. "Paper del receptor CD40 en l'activació de les cèl·lules endotelials. Rellevància de la interacció CD40-CD40L en processos immunoinflamatoris." Doctoral thesis, Universitat de Barcelona, 2007. http://hdl.handle.net/10803/1884.

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CD40 (TNFRSF5) és una glicoproteïna de membrana que pertany a la família de receptors del factor de necrosi tumoral (TNF-R). La interacció amb el seu lligand fisiològic (CD40L o CD154) regula una àmplia varietat de funcions biològiques, des de l'activació del sistema immune, tant humoral com cel·lular, a diferents aspectes de la resposta inflamatòria. <br/>Els principals objectius d'aquesta tesi han estat 1) l'estudi a nivell molecular del paper de CD40 en l'activació de les cèl·lules endotelials, i 2) les conseqüències del bloqueig d'aquesta via de senyalització en la resposta immunoinflamatò
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Meunier, Sylvain. "Impact de l’interaction CD40/CD40L sur les différents intervenants de la réponse immunitaire T CD8." Paris 5, 2011. http://www.theses.fr/2011PA05T039.

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Mon sujet de thèse consiste à étudier le rôle des différentes voies possible à l’interaction CD40/CD40L au cours de la réponse primaire des lymphocytes T CD8 et à caractériser la réponse des lymphocytes T CD8 CD40-/-. Les résultats obtenus jusqu’à présent semblent montrer deux effets à une interaction CD40/CD40L en fonction de la localisation de la molécule CD40 selon le type cellulaire (sur les lymphocytes T CD8 ou sur les cellules présentatrices d’antigène). Le premier effet est la mis en place d’une réponse primaire optimale de la part des lymphocytes T CD8 et est dû à l’expression de CD40
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Sakai, Hidemasa. "The CD40-CD40L axis and IFN-γ play critical roles in Langhans giant cell formation". Kyoto University, 2012. http://hdl.handle.net/2433/158049.

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Books on the topic "Cd40lg-"

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Cooke, Peter William. CD40 expression in bladder cancer. University of Birmingham, 2001.

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Wheeler, Kay. The role of CD40 in human B cell activation. University of Birmingham, 1993.

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Davies, Clare Charlotte. Mechanisms of CD40 signalling and apoptosis in carcinoma cells. University of Birmingham, 2003.

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Armour, Carolyn Anne. The role of CD40 in the regulation of cell growth. University of Birmingham, 1998.

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Baker, Matthew Paul. Functional and molecular aspects of CD40 signalling in human B cells. University of Birmingham, 1997.

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Teale, Glyn Robert. Characterisation of the CD40 cell surface receptor in cervical invasive and preinvasive disease. University of Birmingham, 2001.

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Püschner, Stephanie Marie. Die Bedeutung Tumor Nekrose Faktor Rezeptor assoziierter Faktoren für die Signaltransduktion des CD40 Rezeptors. [s.n.], 2000.

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Total integrated dose testing of solid-state scientific CD4011, CD4013, and CD4060 devices with CO-60 gamma rasys. National Aeronautics and Space Administration, 1985.

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Lucas, Carrie Lynn. Mechanisms of deletional tolerance of peripheral CD8⁺ T cells induced by anti-CD40L and allogeneic bone marrow transplantation. 2010.

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Breisgau, Universität Freiburg im, ed. T-Zell/B-Zellinteraktion bei Variablem Immundefektsyndrom (CVI): Phänotypische Analyse der Expression des Ligandenpaares CD40/CD40-Ligand und der B7-Familie. 1994.

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Book chapters on the topic "Cd40lg-"

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Kotlyar, David, and Anthony Leonardi. "Anti-CD40/Anti-CD40L." In Cancer Therapeutic Targets. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4419-0717-2_92.

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Kotlyar, David, and Anthony Leonardi. "Anti-CD40/Anti-CD40L." In Cancer Therapeutic Targets. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6613-0_92-1.

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Law, Che-Leung, and Iqbal S. Grewal. "Therapeutic Interventions Targeting CD40L (CD154) and CD40: The Opportunities and Challenges." In Advances in Experimental Medicine and Biology. Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-89520-8_2.

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Wenzel, Folker. "Soluble CD40L in Stem Cell Products." In Stem Cells and Cancer Stem Cells, Volume 12. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-017-8032-2_21.

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Bishop, Gail A., and Bruce S. Hostager. "CD40." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_148.

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Covey, Lori R. "CD40." In Encyclopedia of Medical Immunology. Springer New York, 2014. http://dx.doi.org/10.1007/978-0-387-84828-0_32.

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Bishop, Gail A., and Bruce S. Hostager. "CD40." In Encyclopedia of Signaling Molecules. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_148-1.

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van Roy, Frans, Volker Nimmrich, Anton Bespalov, et al. "CD40." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_148.

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Burkly, Linda C. "CD40L Pathway Blockade as an Approach to Immunotherapy." In Advances in Experimental Medicine and Biology. Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1277-6_12.

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Schultz, A., A. Greiner, R. Nenninger, et al. "CD40-Expression in Thymoma." In Epithelial Tumors of the Thymus. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-0033-3_31.

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Conference papers on the topic "Cd40lg-"

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França, Tábata Takahashi, Luiz Fernando Bacarini Leite, Tiago Arruda Maximo, et al. "NOVA MUTAÇÃO NO GENE CD40LG EM PACIENTE COM FENÓTIPO BRANDO DE SÍNDROME DE HIPER- IGM LIGADA AO X." In 4º Congresso Internacional Sabará de Saúde Infantil. Editora Blucher, 2020. http://dx.doi.org/10.5151/cissi2020-54.

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Merz, Christian, Jaromir Sykora, Meinolf Thiemann, et al. "Abstract 1688: HERA-CD40L: A novel hexavalent CD40 agonist with superior biological activity." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-1688.

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Sun, Zhijian, and Lusong Luo. "Abstract 1298: CD40L-CD40 signaling on B-cell lymphoma response to BTK inhibitors." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1298.

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Merz, Christian, Jaromir Sykora, Viola Marschall, et al. "Abstract 1760: The hexavalent CD40 agonist HERA-CD40L augments multi-level crosstalk between T cells and antigen-presenting cells." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1760.

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Bauer, NN, JT Baker, J. Rai, and TM Moore. "Soluble CD40L Directly Regulates PMVEC Barrier Function." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2327.

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Glick, Adam B., Jacob T. Bailey, Andrew Gunderson, Kyle Breech, and Michael Podolsky. "Abstract 2673: Divergent therapeutic responses to CD40L blockade or CD40 activation in Ras-driven skin cancers determined by origin of tumor initiating cell." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2673.

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Gieffers, Christian, David M. Richards, Jaromir Sykora, et al. "Abstract 1076: Hexavalent HERA-CD40L induces a productive T cell-mediated anti-tumor immune response and shows superior activity in comparison to benchmark CD40 agonistic antibodies." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-1076.

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Trella, Emanuele. "Abstract A016: Multipotency of a CD40L-expressing recombinant vaccinia virus." In Abstracts: Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; September 25-28, 2016; New York, NY. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/2326-6066.imm2016-a016.

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Gieffers, Christian, Jaromir Sykora, Christian Merz, et al. "Abstract 5015: HERA-CD40L a hexavalent CD40 agonist induces T cell mediated anti-tumor immune response and shows superior activity in direct comparison to benchmark agonistic antibodies." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-5015.

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Gieffers, Christian, Jaromir Sykora, Christian Merz, et al. "Abstract 5015: HERA-CD40L a hexavalent CD40 agonist induces T cell mediated anti-tumor immune response and shows superior activity in direct comparison to benchmark agonistic antibodies." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-5015.

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Reports on the topic "Cd40lg-"

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Sorensen, Neil Robert. Failure analysis for the dual input quad NAND gate CD4011 under dormant storage conditions. Office of Scientific and Technical Information (OSTI), 2007. http://dx.doi.org/10.2172/908064.

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Sorensen, Neil Robert. Failure analysis for the dual input quad NAND fate CD4011 under dormant storage conditions. Office of Scientific and Technical Information (OSTI), 2004. http://dx.doi.org/10.2172/975246.

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Mahanonda, Rangsini, Orawan Charatkulangkun, and Sathit Pichyangkul. The role of IL-17 in periodontitis. Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.12.

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Background and objectives: IL-17 is a novel T cell-derived cytokine that promotes inflammatory responses. It is presence in inflamed gingival tissues and gingival crevicular fluid of periodontitis patients. In this study we investigated the effects of IL-17 alone or in combination with IFN-Y on the immune modulation of human gingival fibroblasts (HGFs) which would contribute to pathogenesis of periodontium. Methods and results: Various concentrations of IL-17, IFN-Y or the combination of these two cytokines were added to HGF cultures. The expression of ICAM-1, HLA-DR, and CD40 was assessed by
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