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Dissertations / Theses on the topic 'Cd40lg-'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

MERCURI, ELISABETTA. "PRECLINICAL MODELING HIGHLIGHTS THE THERAPEUTIC POTENTIAL OF THE ADOPTIVE TRANSPLANT OF GENE CORRECTED T CELLS IN X-LINKED HYPER-IGM IMMUNODEFICIENCY." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2020. http://hdl.handle.net/10281/263922.

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La terapia genica di cellule staminali ematopoietiche (HSC) ha prodotto benefici clinici in diversi pazienti affetti da una varietà di malattie genetiche. Tuttavia, l’uso di vettori che si integrano nel genoma in modo semi-casuale pone il rischio di mutagenesi inserzionale e di una espressione del transgene ectopica/non regolata. Quest’ultimo problema è particolarmente rilevante quando si trattano geni strettamente regolati attivi sulla proliferazione cellulare, come il gene CD40LG, la cui espressione sulle cellule T attivate porta all’attivazione contatto-dipendente delle cellule B, alla loro

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2

Yeboah, Sybil A. Parise Leslie V. "Do CD40L and CD40 contribute to sickle cell anemia?" Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1640.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the degree of Master of Science in the Department of Biochemistry." Discipline: Biochemistry and Biophysics; Department/School: Medicine.

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3

Martins, Ryan Stephen. "Tumor-Bearing Host Macrophage Dysfunction: Role of CD40/CD40L Interactions." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/32405.

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A functional immune system is a potential barrier to tumor growth and progression. Cancer is caused, in part, by the loss of immune surveillance leading to the inability of the immune system to destroy the cancer cells. Macrophages (Mfs) are essential cellular components of the immune system; they influence immune responses in diverse and fundamental ways. As a consequence, Mfs present targets for tumors to evade, thereby enhancing tumor survival and growth. An interaction between CD40 on Mfs and CD40L on T cells is required for cell-mediated inflammatory responses. The CD40/CD40L interactio

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4

Oxer, Daniella Stefani. "Interação entre as vias de sinalização CD40/CD40L e os PPARs." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5159/tde-17062009-122735/.

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O receptor CD40 e seu ligante CD40L possuem um papel importante na interface entre a resposta imune inata e a adaptativa. Disfunções desta via de sinalização são descritas em doenças de origem inflamatória e autoimunes. Em Lúpus eritematoso sistêmico (LES) foi descrito um aumento nos níveis séricos de CD40L solúvel, que participa na produção de autoanticorpos. Receptores ativados por proliferadores de peroxisomos (PPARs) são fatores de transcrição que inicialmente foram descritos como envolvidos apenas no metabolismo lipídico, mas que atualmente são também descritos como atuantes no controle d

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5

Macina, Denis. "Étude de l'implication du système CD40/CD40L dans le syndrome hyper-IGM." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq33704.pdf.

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6

Morgenroth, Iris. "Charakterisierung des CD40-CD40L-Systems als wichtiger Regulator der B-Zellfunktion des Haushuhns." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-77513.

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7

Bürger, Christina [Verfasser], and Sabine [Akademischer Betreuer] Steffens. "Cell type-specific CD40-CD40L interaction in atherosclerosis / Christina Bürger ; Betreuer: Sabine Steffens." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1142787141/34.

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8

Pluvinet, Ortega Raquel. "Paper del receptor CD40 en l'activació de les cèl·lules endotelials. Rellevància de la interacció CD40-CD40L en processos immunoinflamatoris." Doctoral thesis, Universitat de Barcelona, 2007. http://hdl.handle.net/10803/1884.

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CD40 (TNFRSF5) és una glicoproteïna de membrana que pertany a la família de receptors del factor de necrosi tumoral (TNF-R). La interacció amb el seu lligand fisiològic (CD40L o CD154) regula una àmplia varietat de funcions biològiques, des de l'activació del sistema immune, tant humoral com cel·lular, a diferents aspectes de la resposta inflamatòria. <br/>Els principals objectius d'aquesta tesi han estat 1) l'estudi a nivell molecular del paper de CD40 en l'activació de les cèl·lules endotelials, i 2) les conseqüències del bloqueig d'aquesta via de senyalització en la resposta immunoinflamatò

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9

Meunier, Sylvain. "Impact de l’interaction CD40/CD40L sur les différents intervenants de la réponse immunitaire T CD8." Paris 5, 2011. http://www.theses.fr/2011PA05T039.

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Mon sujet de thèse consiste à étudier le rôle des différentes voies possible à l’interaction CD40/CD40L au cours de la réponse primaire des lymphocytes T CD8 et à caractériser la réponse des lymphocytes T CD8 CD40-/-. Les résultats obtenus jusqu’à présent semblent montrer deux effets à une interaction CD40/CD40L en fonction de la localisation de la molécule CD40 selon le type cellulaire (sur les lymphocytes T CD8 ou sur les cellules présentatrices d’antigène). Le premier effet est la mis en place d’une réponse primaire optimale de la part des lymphocytes T CD8 et est dû à l’expression de CD40

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10

Sakai, Hidemasa. "The CD40-CD40L axis and IFN-γ play critical roles in Langhans giant cell formation". Kyoto University, 2012. http://hdl.handle.net/2433/158049.

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11

Hirano, Ayumi. "T dependent B cell help in cattle : immunoregulatory function of interleukin-4 and CD40-CD40L interactions /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841150.

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12

NATOLI, SILVIA. "Riduzione della risposta monocitica al CD40L in corso di sepsi." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/1115.

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E’ stato suggerito che un sistema immunitario adattativo deficitario contribuisca all’immunosoppressione che si verifica in corso di sepsi. In questo lavoro si sono analizzate le risposte al CD40L di monociti prelevati da pazienti con sepsi da batteri Gram negativi. Se paragonati alle cellule prelevate da controlli sani, i monociti dei pazienti settici dimostravano una produzione significativamente ridotta di TNFα, IL-1β e IL-12 ed erano incapaci di esprimere alti livelli di CD80 e CD86 in seguito alla stimolazione con CD40L. Queste alterazioni che si sono osservate all’insorgenza della sepsi

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13

Michels, Monique. "Interação entre o receptor de membrana CD40 e o seu ligante CD40L sobre mecanismos neuroinflamatórios e comportamentais associados à sepse." reponame:Repositório Institucional da UNISUL, 2014. http://www.riuni.unisul.br/handle/12345/521.

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Made available in DSpace on 2016-11-30T14:53:34Z (GMT). No. of bitstreams: 2 109331_Monique.pdf: 821126 bytes, checksum: 211cd45acfda901f7808b74a824a0d73 (MD5) license.txt: 214 bytes, checksum: a5b8d016460874115603ed481bad9c47 (MD5) Previous issue date: 2014<br>A sepse e síndrome de disfunção orgânica múltipla representam um problema clínico de alta relevância, principalmente devido a sua grande incidência em pacientes críticos e aos seus altos índices de mortalidade. Apesar de medidas terapêuticas terem sido capazes de diminuir a mortalidade, sabe-se que muitos sobreviventes de sepse não

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Liljenfeldt, Lina. "CD40L Gene Therapy for Solid Tumors." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-222705.

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Adenoviral CD40L gene therapy (AdCD40L) is a strong inducer of anti-tumor immune responses via its activation of dendritic cells (DCs). Activated DCs can in turn activate T cells, which are key players in an efficient anti-tumor response. This thesis includes three papers that focus on different aspects of AdCD40L gene therapy. In the first paper, the infiltration of suppressive CD11b+Gr-1+ cells in orthotopic MB49 bladder tumors was investigated and found to be significantly reduced while activated T cells were increased when the tumors had been treated with local AdCD40L gene therapy. Furthe

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15

Henrique, Rocha Agnellini Andrielly. "The role of nitric oxide in cancer immunotherapy." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424452.

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The adoptive cell therapy (ACT) represents one promising and realistic strategy to treat cancer patients trough cancer immunotherapy. This clinical approach consists in the transfer of CD8+ T lymphocytes, specific for tumor antigens. The effectiveness of ACT so far is limited by crucial events as the trafficking of adoptively transferred cells to the tumor site and the highly immunosuppressive environment of developing cancer. Tumors are complex and flexible lesions where cancer cells and host immune cells dynamically interact. The immunosuppressive functions are exerted by distinct cell popu

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16

Inwald, David Philip. "The role of platelet CD40L in inflammation." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446614/.

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CD40L is a membrane protein belonging to the tumour necrosis factor family, originally found on activated T cells. The CD40L-CD40 interaction is of critical importance in the adaptive immune response, in innate immunity and in inflammation. Recently, activated platelets have been found to express CD40L. Platelets can stimulate endothelial cells via a CD40L-CD40 interaction to upregulate adhesion molecule expression, tissue factor expression and cytokine production. The aim of this project was to investigate the role of platelet CD40L in inflammation, focusing particularly on the platelet-monoc

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17

Capobianco, Marcela Petrolini [UNESP]. "Polimorfismos dos Genes CD40, CD40L e BLYS, associados na co-estimulação dos Linfócitos B, em indivíduos naturalmente infectados pelo Plasmodium vivax na Amazônia Brasileira." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/92537.

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Made available in DSpace on 2014-06-11T19:26:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-02-22Bitstream added on 2014-06-13T18:29:26Z : No. of bitstreams: 1 capobianco_mp_me_sjrp.pdf: 879411 bytes, checksum: 7dc3528f12158026ba11087f62447e13 (MD5)<br>Plasmodium vivax é a espécie mais prevalente de malária no Brasil. O processo co-evolutivo parasita-hospedeiro pode ser visto como uma ferramenta, na qual trocas genéticas adaptativas podem influenciar na diversidade da população. Objetivo: Investigar polimorfismos de genes envolvidos na resposta imune humoral visando identificar po

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Capobianco, Marcela Petrolini. "Polimorfismos dos Genes CD40, CD40L e BLYS, associados na co-estimulação dos Linfócitos B, em indivíduos naturalmente infectados pelo Plasmodium vivax na Amazônia Brasileira /." São José do Rio Preto, 2013. http://hdl.handle.net/11449/92537.

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Orientador: Ricardo Luiz Dantas Machado<br>Banca: Ana Elizabete Silva<br>Banca: Karin Kirchgatter<br>Resumo: Plasmodium vivax é a espécie mais prevalente de malária no Brasil. O processo co-evolutivo parasita-hospedeiro pode ser visto como uma "ferramenta", na qual trocas genéticas adaptativas podem influenciar na diversidade da população. Objetivo: Investigar polimorfismos de genes envolvidos na resposta imune humoral visando identificar possíveis associações com a malária. Material e Métodos: a amostra foi constiuída por 103 pacientes com malária vivax não complicada e como grupo controle 97

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19

Rousseau, Raphaël. "Application du transfert de gène à l'immunothérapie antitumorale : du développement préclinique aux essais cliniques de phase I dans les leucémies et les neuroblastomes de haut risque." Paris 7, 2002. http://www.theses.fr/2002PA077168.

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20

Marques, Otávio Cabral. "Alterações genético-moleculares em pacientes deficientes de CD40L." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-19112008-162056/.

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A deficiência de CD40 Ligante (CD40L) ou síndrome de Hiper-IgM ligada ao X (X-HIGM) é considerada uma imunodeficiência primária combinada de células T e B. O CD40L é expresso na superfície de linfócitos T ativados e interage com o CD40 expresso na superfície de linfócitos B, macrófagos, células dendríticas, células endoteliais e neutrófilos. A interação CD40L-CD40 transmite sinais que induzem ativação, diferenciação e proliferação celular. Nosso objetivo foi analisar as alterações genético-moleculares da molécula CD40L que acometeram indivíduos de 5 famílias brasileiras, ocasionando X-HIGM. Ge

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21

Grosdidier, Charlotte. "Anti-plaquettaires et risque hémorragique : rôle du CD40L." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5063/document.

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Le traitement des patients avec une coronarographie après un SCA est l'aspirine et les thiénopyridines. La réponse aux thiénopyridines est variable, cette variabilité, multifactorielle, a des répercutions cliniques. Leur efficacité a été évaluée sur la réduction de la survenue d'évènements cliniques et peu sur le risque d'hémorragie qui est un effet indésirable majeur. Les plaquettes, jouent un rôle dans l'athérosclérose et les SCA notamment par le CD40L.J'ai étudié les facteurs plaquettaires conditionnant le risque hémorragique chez ces patients et apporté un éclairage sur des fonctions plaqu

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22

Angin, Mathieu. "Induction de tolérance en transplantation par blocage de la voie CD40/CD40L : caractérisation des cellules tolérogènes induites chez le rat et évaluation chez le primate." Nantes, 2008. https://archive.bu.univ-nantes.fr/pollux/show/show?id=e840c663-196c-4edc-9608-019f57b0bd82.

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Le blocage de la voie de costimulation CD40/CD40L par injection d'un adénovirus codant pour CD40Ig génère des lymphocytes T régulateurs CD8+CD45RClo capables d'induire une tolérance indéfinie d'une allogreffe cardiaque chez le rat. L'étude du transcriptome de ces lymphocytes TCD8+ tolérogènes par puce à ADN a permis d'établir des hypothèses quant aux mécanismes impliqués. Le rôle de l'IFNg est retrouvé et pourrait induire l’expression d'une protéine immuno-régulatrice Fgl2. La présence des molécules du CMH de classe II semble également importante. De nombreuses molécules observées dans des ana

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Becker, Hans Jiro [Verfasser]. "Einfluss der Hypoxie auf den Immunphänotyp sowie auf die mRNA- und miRNA-Expressionsprofile CD40-aktivierter B-Zellen (CD40Bs) / Hans Jiro Becker." Köln : Deutsche Zentralbibliothek für Medizin, 2016. http://d-nb.info/1104192764/34.

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24

Rehklau, Jutta. "Untersuchung der Einflüsse auf die Regulation des Zelloberflächenmoleküles CD40L." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-10558.

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Wolf, Dennis [Verfasser], and Andreas [Akademischer Betreuer] Zirlik. "Deskriptive und funktionelle Charakterisierung der CD40L/Mac-1 Interaktion." Freiburg : Universität, 2012. http://d-nb.info/112347009X/34.

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26

Mühle, Kerstin. "Interaction of CD8+CD40L+ T cells with B cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19127.

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ZTLs vermitteln die Eliminierung von infizierten und entarteten Zellen durch Apoptose. Neuste Erkenntnisse unserer Gruppe haben gezeigt, dass eine Subpopulation der CD8+ T-Zellen, anstelle der zytotoxischen Marker das Oberflächenmolekül CD40L exprimiert. Die Expression von CD40L ist bislang als Schlüsselmolekül für die CD4+ T-Zell vermittelte Hilfe bekannt, welche durch Bindung an den CD40 Rezeptor auf anderen Immunzellen induziert wird. Das von den CD4+ T–Zellen ausgehende CD40L Signal ist besonders für die T-Zell abhängige B-Zell Aktivierung und die Bildung von Keimzentren essentiell, in den

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Loyal, Lucie. "The molecular regulation of CD40L in CD8+ T cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/20158.

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T Zellen können in zwei Hauptpopulationen mit unterschiedlichen Aufgaben unterschieden werden. CD4+ T Zellen exprimieren im Zuge ihrer Aktivierung CD40L, welches ein zentraler kostimulatorischer Rezeptor zur Induktion von B-Zell basierter humoraler Immunität, APC Aktivierung und einer effizienten Effektor CD8+ T Zell Entwicklung ist („Helfer-Funktion“). Im Gegensatz dazu sind die zytotoxischen CD8+ T Zellen dazu vorbestimmt, infizierte oder maligne Zellen direkt abzutöten. Jedoch wurde eine Fraktion von CD8+ T Zellen identifiziert, die nach Aktivierung CD40L exprimiert. Bisher ist nicht versta

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Tariket, Sofiane. "Investigation de la pathogenèse du syndrome de détresse respiratoire aiguë post-transfusionnel (TRALI) dans un modèle murin." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSES059/document.

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La transfusion sanguine permet de sauver des vies et réduit la morbidité pour un grand nombre de maladies et d'affections cliniques, mais elle n'est pas exempte de complications. Un incident néfaste lié à une transfusion, également appelé Effet Indésirable Receveur (EIR), est un incident défavorable survenant chez un patient pendant ou après une transfusion sanguine. Parmi eux, le TRALI est considéré comme l’une des réactions inflammatoires les plus critiques. Cette pathologie se développe généralement dans les 6 heures après transfusion. On en reconnaît deux types, les TRALI immunologiques et

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Bukosza, Eva Nora [Verfasser], and Andreas [Akademischer Betreuer] Zirlik. "Contribution of CD40L/Mac-1 pathway to the metabolic syndrome." Freiburg : Universität, 2018. http://d-nb.info/1156532655/34.

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Wieckowski, Sébastien. "Synthetic CD40L mimetics : Biological effects and potential applications in immunotherapy." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. https://publication-theses.unistra.fr/public/theses_doctorat/2007/WIECKOWSKI_Sebastien_2007.pdf.

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Le couple CD40/CD40L joue un rôle central dans le système immunitaire. CD40 appartient à la famille des récepteurs au TNF (tumor necrosis factor), et est constitutivement exprimé par les lymphocytes B, les cellules dendritiques et les monocytes/macrophages. Son ligand, CD40L, est un membre de la famille du TNF qui est exprimé transitoirement sur les cellules T activées. Les protéines de la superfamille des TNF-R/TNF s’assemblent selon une symétrie C3, formant des complexes hexavalents importants pour la transduction des signaux intracellulaires. Différents groupes ont utilisé des anticorps dir

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Wieckowski, Sébastien Fournel Sylvie Guichard Gilles. "Synthetic CD40L mimetics Biological effects and potential applications in immunotherapy /." Strasbourg : Université Louis Pasteur, 2008. http://eprints-scd-ulp.u-strasbg.fr:8080/903/01/WIECKOWSKI_Sébastien_2007.pdf.

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Thèse de octorat : Aspects moléculaires et cellulaires de la biologie. Immunologie : Strasbourg 1 : 2007.<br>Thèse soutenue sur un ensemble de travaux. Titre provenant de l'écran-titre. Notes bibliogr.

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Duran, Amparo. "Investigation of a Trimeric Hemagglutinin Stem Domain from Influenza B for a Universal Vaccine." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38200.

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Influenza infection occurs in as much as 5–15% of the world population, resulting in 3–5 million cases of severe illness and up to 500,000 deaths annually. According to the CDC, on average 24% of all influenza positive respiratory samples during 2001 to 2011 tested positive for Influenza B. Influenza has two main surface glycoproteins, neuraminidase (NA) and hemagglutinin (HA), HA being responsible for the binding of the virus to the host cell. Currently, seasonal influenza vaccines are produced using two strains of Influenza A and one or two strains of Influenza B viruses recommended by the W

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Field, Ann Elizabeth. "The development and characterization of transgenic Leishmania major expressing murine CD40L." College Park, Md. : University of Maryland, 2007. http://hdl.handle.net/1903/7006.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2007.<br>Thesis research directed by: Cell Biology & Molecular Genetics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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Abduh, Maisa. "Follicular CD4 T Cells Tutor CD8 Early Memory Precursors : an Initiatory Journey to the Frontier of B Cell Territory." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS371.

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Les lymphocytes T CD8+ spécifiques de l'antigène sont impliqués dans la réponse immunitaire adaptative et jouent un rôle essentiel dans la protection de l'hôte contre l'infection par des pathogènes intracellulaires. Cette protection de longue durée dépend de la génération de réponses lymphocytaires T CD8+ mémoires, hautement fonctionnelles en termes de fréquence et de fonctionnalité, après réinfection.Après présentation de l'antigène, une cellule T CD8 naïve subit une forte expansion clonale, générant une population hétérogène de cellules activées qui est dominée, au sommet de l'expansion, par

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Pietravalle, Fabienne. "Identification, caractérisation, et étude de l'activité biologique des formes solubles du CD40L." Toulouse 3, 1996. http://www.theses.fr/1996TOU30321.

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En presence d'un antigene t-dependant, l'activation des lymphocytes b, menant a la production d'anticorps specifiques, requiert l'aide des lymphocytes tauxiliaires (tn). Ces derniers controlent la reponse en anticorps en secretant des cytokines ou en exprimant de nouvelles proteines membranaires. Parmi elles, le ligand du cd40 ou cd40l, joue un role primordial dans le controle de la reponse immune. C'est une glycoproteine transmembranaire de 33kda, d'abord identifiee a la surface des cellules t activees puis sur les mastocytes et basophiles. En presence d'il-4 ou d'il-13, l'interaction du cd40

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Wagner, Nikki J. Vilen Barbara J. "In vivo regulation of autoreactive B cells by IL-6, CD40L and TNF[alpha]." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2132.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Feb. 17, 2009). "... in partial fulfillment of the requirements for the degree of Masters in Science in the Department of Microbiology and Immunology." Discipline: Microbiology and Immunology; Department/School: Medicine. On title page, [alpha] appears as Greek character.

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Schubert, Lisa Ann. "Characterization of the transcriptional regulation of the human CD40L gene in CD4 T cells /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/8325.

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38

Lee, Sheritha P. Parise Leslie V. "Chronic inflammation in sickle cell disease potential role of platelets and the inflammatory mediator CD40L /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,497.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillments of the requirements for the degree of Doctor of Philosophy in the Department of Pharmacology." Discipline: Pharmacology; Department/School: Medicine.

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Guillonneau, Carole. "Etude du rôle de différentes voies de costimulation dans le rejet d' allogreffe cardiaque chez le rat." Paris 7, 2005. http://www.theses.fr/2005PA077097.

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HASEGAWA, YOSHINORI, KAZUYOSHI IMAIZUMI, NAOZUMI HASHIMOTO, MIYOKO MATSUSHIMA, and TSUTOMU KAWABE. "CD40/CD40 LIGAND INTERACTIONS IN IMMUNE RESPONSES AND PULMONARY IMMUNITY." Nagoya University School of Medicine, 2011. http://hdl.handle.net/2237/15350.

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Dias, Junior Pedro Paulo 1986. "Avaliação das proteínas inflamatórias CD40L e light nas propriedades adesivas dos neutrófilos e outros tipos celulares." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311497.

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Orientador: Nicola Amanda Conran Zorzetto<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T11:46:04Z (GMT). No. of bitstreams: 1 DiasJunior_PedroPaulo_M.pdf: 932681 bytes, checksum: a8ceae0940e26759a4abe344de43b8f4 (MD5) Previous issue date: 2012<br>Resumo: A resposta vascular inflamatória envolve a interação complexa entre células. A adesão dos neutrófilos aos sítios inflamatórios é constituído de várias etapas que envolvem a interação das moléculas de adesão com os neutrófilos, intermediado pela L-selecti

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Merlotti, Guido. "Role of lymphocyte co-stimulation pathways and extracellular vesicles in cardiovascular damage of chronic uremic patients and new therapeutic strategies." Doctoral thesis, Università del Piemonte Orientale, 2021. http://hdl.handle.net/11579/127932.

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Introduction: Chronic kidney disease (CKD) is characterized by high cardiovascular (CV) risk and the RISCAVID study identified a correlation between CV risk and blood levels of sCD40L in uremia. Moreover, sCD40L correlates with osteoblastic differentiation of vascular smooth muscle cells (VSMC) and endothelial cells (EC) inflammation. In addition, CKD-related extracellular vesicles (EVs) express CD40L and polymethylmethacrylate (PMMA) dialyzer could reduce not only uremic toxins as indoxyl sulfate (IS), but also sCD40L and EVs by adsorption. Aim of the study: 1) identify a sCD40L predictive v

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Oliveira, Fabrícia Alvisi de. "Participação do CD40L solúvel e da metaloproteinase de matriz -9 na resposta imune na leishmaniose visceral humana." Universidade Federal de Sergipe, 2016. https://ri.ufs.br/handle/riufs/3621.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>In the present study, the sera levels of soluble CD40 ligand (sCD40L) and matrix metalloproteinase-9 (MMP-9) were quantified by Luminex assay in Visceral leishmaniasis patients before and during treatment follow-up and after regular antimony treatment and also in individuals exposed to infection, living in endemic areas. Different from the other molecules present in sera from classic VL patients, sCD40L and MMP-9 are fairly increased, and increase over time during the follow-up of VL patients undergoing antimony treatm

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Garrido, Vanessa Tonin 1985. "Avaliação do papel das citocinas inflamatórias, LIGHT e CD40L, na inflamação mediada por plaquetas na anemia falciforme." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312445.

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Orientador: Nicola Amanda Conran Zorzetto, Fernando Ferreira Costa<br>Texto em português e inglês<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-24T19:18:22Z (GMT). No. of bitstreams: 1 Garrido_VanessaTonin_D.pdf: 6610754 bytes, checksum: 9b799d90821835bae6ac5d806b1d2f1c (MD5) Previous issue date: 2014<br>Resumo: A anemia falciforme (AF) é uma hemoglobinopatia hereditária resultante de uma mutação no gene que codifica a subunidade ?-globina, levando à produção da hemoglobina S (HbS) nos eritrócitos. Com a polimeri

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Brittain, George C. IV. "A Novel Role for the TRAFs as Co-Activators and Co-Repressors of Transcriptional Activity." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/451.

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The tumor necrosis factor (TNF) receptor-associated factors (TRAFs) were initially discovered as proteins that inducibly interact with the intracellular region of TNF receptors (TNFRs). Because the TNFRs lack intrinsic catalytic activity, the TRAFs are hypothesized to orchestrate signaling activation downstream of the TNFR superfamily, however their mechanism of activation remains unclear (Inoue et al., 2000; Bishop, 2004). Originally, the TRAFs were compared to the signal transducers and activators of transcription (STAT) protein family, due to their sequence homology, and the presence of mul

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Bungenstock, Anne. "Endothelzellmigration." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2003. http://dx.doi.org/10.18452/14935.

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Angiogenese, die Bildung neuer Blutgefäße aus bereits bestehender Vaskulatur, ist ein Prozeß, der sowohl unter physiologischen Bedingungen abläuft, wie bei der Embryonalentwicklung und der Wundheilung, als auch unter pathologischen Bedingungen, wie der diabetischen Retinopathie und dem Wachstum und der Metastasierung solider Tumoren. Chronische Entzündungen wie die Atherosklerose und die Rheumatoide Arthritis gehen ebenfalls mit angiogenetischen Prozessen einher. Die Angiogenese ist ein stark regulierter Vorgang, der Migration, Proliferation und Differenzierung der Endothelzellen erfordert. D

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Blankenbach, Hermann [Verfasser], and Dennis [Akademischer Betreuer] Wolf. "Generierung und Charakterisierung eines neuen Liganden- und Aktivitäts-spezifischen Antikörpers zur selektiven Hemmung der CD40L/Mac-1 Interaktion." Freiburg : Universität, 2016. http://d-nb.info/112264731X/34.

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Tahir, Sibgha [Verfasser], and Markus [Akademischer Betreuer] Hecker. "CD40L-dependent von Willebrand factor-platelet string formation in the mouse microcirculation in vivo / Sibgha Tahir ; Betreuer: Markus Hecker." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177691280/34.

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Mühle, Kerstin [Verfasser], Hans-Dieter [Gutachter] Volk, Andreas [Gutachter] Thiel, and Ulf [Gutachter] Wagner. "Interaction of CD8+CD40L+ T cells with B cells / Kerstin Mühle ; Gutachter: Hans-Dieter Volk, Andreas Thiel, Ulf Wagner." Berlin : Humboldt-Universität zu Berlin, 2018. http://d-nb.info/1185495924/34.

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Loyal, Lucie [Verfasser], Andreas [Gutachter] Thiel, Chiara [Gutachter] Romagnani, and Hans-Dieter [Gutachter] Volk. "The molecular regulation of CD40L in CD8+ T cells / Lucie Loyal ; Gutachter: Andreas Thiel, Chiara Romagnani, Hans-Dieter Volk." Berlin : Humboldt-Universität zu Berlin, 2019. http://d-nb.info/1190641046/34.

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