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Relevant bibliographies by topics / Cell death rate of gbm cells

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Academic literature on the topic 'Cell death rate of gbm cells'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Cell death rate of gbm cells"

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Dastghaib, Sanaz, Shahla Shojaei, Zohreh Mostafavi-Pour, et al. "Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells." Cells 9, no. 11 (2020): 2339. http://dx.doi.org/10.3390/cells9112339.

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Glioblastoma (GBM) is the most prevalent malignant primary brain tumor with a very poor survival rate. Temozolomide (TMZ) is the common chemotherapeutic agent used for GBM treatment. We recently demonstrated that simvastatin (Simva) increases TMZ-induced apoptosis via the inhibition of autophagic flux in GBM cells. Considering the role of the unfolded protein response (UPR) pathway in the regulation of autophagy, we investigated the involvement of UPR in Simva–TMZ-induced cell death by utilizing highly selective IRE1 RNase activity inhibitor MKC8866, PERK inhibitor GSK-2606414 (PERKi), and eIF

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Fann, Li-Yun, Jui-Hu Shih, Jen-Ho Tseng, Hsu-Shan Huang, and Sheng-Huang Hsiao. "CC12 Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Lines and Mouse Xenograft Model." Molecules 25, no. 8 (2020): 1793. http://dx.doi.org/10.3390/molecules25081793.

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Among central nervous system tumors, glioblastoma (GBM) is the most common and the most malignant type. Even under current standard treatments, the overall survival rate is still low and the recurrence rate is high. Therefore, developing novel and effective therapy is urgently needed. CC12, a synthesized small molecule, was evaluated for the potential anti-GBM effects in two GBM cell lines, U87MG and U118MG. The observations of cell morphology, MTT assay, flow cytometry-based apoptosis after CC12 treatment, were conducted. Western blot was performed for the investigation of the apoptotic mecha

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Rowland, Emma, and Nagi G. Ayad. "392 Targeting One-Carbon Metabolism in Brain Cancer." Journal of Clinical and Translational Science 8, s1 (2024): 116–17. http://dx.doi.org/10.1017/cts.2024.342.

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OBJECTIVES/GOALS: Glioblastoma (GBM) is the most malignant brain tumor in adults and remains incurable with an average survival of 15 months after diagnosis. There is great need for treatment options without side effects that are devastating to the quality of life for patients. GBM tumors can circumvent cellular damage by upregulating antioxidant production. METHODS/STUDY POPULATION: Highly aggressive tumors tend to exhibit increased oxidative metabolism, and thus rely on a mechanism to eliminate reactive oxygen species (ROS) in order for cells to evade autophagy and cell death. We propose tha

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Pirmoradi, Leila, Nayer Seyfizadeh, Saeid Ghavami, Amir A. Zeki, and Shahla Shojaei. "Targeting cholesterol metabolism in glioblastoma: a new therapeutic approach in cancer therapy." Journal of Investigative Medicine 67, no. 4 (2019): 715–19. http://dx.doi.org/10.1136/jim-2018-000962.

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Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor known with a poor survival rate despite current advances in the field of cancer. Additional research into the pathophysiology of GBM is urgently needed given the devastating nature of this disease. Recent studies have revealed the unique cellular physiology of GBM cells as compared with healthy astrocytes. Intriguingly, GBM cells are incapable of de novo cholesterol synthesis via the mevalonate pathway. Thus, the survival of GBM cells depends on cholesterol uptake via low-density lipoprotein receptors (LDLRs) in the for

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Vivithanaporn, Pornpun, Tanapan Siangcham, Varitta Tanawoot, et al. "Apoptotic and Autophagic Cell Death Effects of the Hexane Extract of Tropical Marine Algae Halymenia durvillei against Human Glioblastoma Cells: In vitro and in silico Studies." Trends in Sciences 21, no. 2 (2023): 7157. http://dx.doi.org/10.48048/tis.2024.7157.

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Glioblastoma (GBM) considered as aggressive brain cancer with high mortality rate in patients even after surgical resection. Resistant to chemotherapy is the major problem in GBM therapy. Discovery of novel bioactive compounds from algae is being investigated as alternative sources for potential treatment as well as prevention in glioblastoma. This study revealed the effects of marine red algae extract from hexane solvent fraction of Halymenia durvillei (HDHE) on proliferation and cell death in A172 human GBM cells. HDHE decreased proliferation and promoted cell cycle arrest at G2/M phase. HDH

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Samiei, Ehsan, Amir Seyfoori, Brian Toyota, Saeid Ghavami, and Mohsen Akbari. "Investigating Programmed Cell Death and Tumor Invasion in a Three-Dimensional (3D) Microfluidic Model of Glioblastoma." International Journal of Molecular Sciences 21, no. 9 (2020): 3162. http://dx.doi.org/10.3390/ijms21093162.

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Glioblastoma multiforme (GBM) is a rapidly progressive and deadly form of brain tumor with a median survival rate of ~15 months. GBMs are hard to treat and significantly affect the patient’s physical and cognitive abilities and quality of life. Temozolomide (TMZ)—an alkylating agent that causes DNA damage—is the only chemotherapy choice for the treatment of GBM. However, TMZ also induces autophagy and causes tumor cell resistance and thus fails to improve the survival rate among patients. Here, we studied the drug-induced programmed cell death and invasion inhibition capacity of TMZ and a meva

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Zalenski, Abby, Miranda Tallman, Luke Kollin, and Monica Venere. "EXTH-38. TARGETING KIF11 TO RADIOSENSITIZE GLIOBLASTOMA." Neuro-Oncology 23, Supplement_6 (2021): vi171—vi172. http://dx.doi.org/10.1093/neuonc/noab196.677.

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Abstract Glioblastoma (GBM) is the most lethal primary brain tumor, with a 5 year survival rate of only 5%. The standard of care for GBM is maximal surgical resection of the tumor, followed by irradiation and chemotherapy. Despite treatment, tumors recur in almost 100% of patients. There are subpopulations of cells in GBM that are radioresistant and chemoresistant, and new treatments will need to inclusively target these cells. KIF11 is a mitotic protein that drives bipolar spindle formation and is crucial for successful completion of mitosis. We previously reported that KIF11 is overexpressed

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Jiang, Michael Q., Shan Ping Yu, Takira Estaba, et al. "Reprogramming Glioblastoma Cells into Non-Cancerous Neuronal Cells as a Novel Anti-Cancer Strategy." Cells 13, no. 11 (2024): 897. http://dx.doi.org/10.3390/cells13110897.

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Glioblastoma Multiforme (GBM) is an aggressive brain tumor with a high mortality rate. Direct reprogramming of glial cells to different cell lineages, such as induced neural stem cells (iNSCs) and induced neurons (iNeurons), provides genetic tools to manipulate a cell’s fate as a potential therapy for neurological diseases. NeuroD1 (ND1) is a master transcriptional factor for neurogenesis and it promotes neuronal differentiation. In the present study, we tested the hypothesis that the expression of ND1 in GBM cells can force them to differentiate toward post-mitotic neurons and halt GBM tumor

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Chen, Dongjiang, Nagheme Thomas, Jie Ren, et al. "IMMU-06. TTFIELDS INDUCES IMMUNOGENIC CELL DEATH AND STING PATHWAY ACTIVATION THROUGH CYTOPLASMIC DOUBLE-STRANDED DNA IN GLIOBLASTOMA CELLS." Neuro-Oncology 21, Supplement_6 (2019): vi120. http://dx.doi.org/10.1093/neuonc/noz175.500.

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Abstract OBJECTIVES Glioblastoma (GBM) is the most common and deadliest malignant brain cancer in adults. Tumor Treating Fields (TTFields) was approved in combination with adjuvant temozolomide chemotherapy for newly diagnosed GBM patients. The addition of TTFields resulted in a significant improvement in overall survival. TTFields are low-intensity alternating electric fields that are thought to disturb mitotic macromolecules’ assembly. In many patients, a transient stage of increased peritumoral edema is often observed early during TTFields treatment followed subsequently by objective radiog

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Zheng, Ping, Dabin Ren, Yu Cong, Xiaoxue Zhang, and Yisong Zhang. "Single-Cell Sequencing Reveals Necroptosis-Related Prognostic Genes of Glioblastoma." Oxidative Medicine and Cellular Longevity 2023 (February 20, 2023): 1–15. http://dx.doi.org/10.1155/2023/2926655.

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Background. Glioblastoma (GBM) is one of the most malignant forms of brain cancer, with the extremely lower survival rate. Necroptosis (NCPS) is also one of the most wide types of cell death, and its clinical importance in GBM is not clear. Methods. We first identified necroptotic genes in GBM by single-cell RNA sequencing analysis of our surgical samples and weighted coexpression network analysis (WGNCA) from TCGA GBM data. The cox regression model with least absolute shrinkage and selection operator (LASSO) was used to construct the risk model. Then, KM plot and reactive operation curve (ROC

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Dissertations / Theses on the topic "Cell death rate of gbm cells"

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PILLAI, Vinoshene. "Intravital two photon clcium imaging of glioblastoma mouse models." Doctoral thesis, Scuola Normale Superiore, 2021. http://hdl.handle.net/11384/109211.

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Books on the topic "Cell death rate of gbm cells"

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Cattran, Daniel C., and Heather N. Reich. Membranous glomerulonephritis. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0064_update_001.

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It has been clear for several decades from comparison with the rodent model disease Heymann nephritis that membranous glomerulonephritis (MGN) is an immune condition in which antibodies, usually autoantibodies, bind to targets on the surface of podocytes. However, the antigen in Heymann nephritis, megalin, is not present on human podocytes. The first potential antigen was identified by studying rare examples of maternal alloimmunization, leading to congenital membranous nephropathy in the infant caused by antibodies to neutral endopeptidase. More recently, the target of autoantibody formation

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Goligorsky, Michael S., Julien Maizel, Radovan Vasko, May M. Rabadi, and Brian B. Ratliff. Pathophysiology of acute kidney injury. Edited by Norbert Lameire. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0221.

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In the intricate maze of proposed mechanisms, modifiers, modulators, and sensitizers for acute kidney injury (AKI) and diverse causes inducing it, this chapter focuses on several common and undisputable strands which do exist.Structurally, the loss of the brush border, desquamation of tubular epithelial cells, and obstruction of the tubular lumen are commonly observed, albeit to various degrees. These morphologic hallmarks of AKI are accompanied by functional defects, most consistently reflected in the decreased glomerular filtration rate and variable degree of reduction in renal blood flow, a

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Book chapters on the topic "Cell death rate of gbm cells"

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Pavard, Samuel, and C. Jessica E. Metcalf. "31. Trade-Offs between Mortality Components in Life History Evolution." In Human Evolutionary Demography. Open Book Publishers, 2024. http://dx.doi.org/10.11647/obp.0251.31.

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Little is known about the relative importance of different causes of death in driving the evolution of senescence and longevity across species. Here we argue that cause-specific mortality may be shaped by physiological trade-offs between mortality components, challenging the theoretical view that physiologically independent processes should senesce at the same rate, or that interactions between causes of death will make selection blind to the effects of specific causes of death. We review the evidence that risk of cancers trades off with risks of mortality from other diseases, and investigate

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Har-Shai, Yaron, and Lior Har-Shai. "Minimally Invasive Technologies for the Treatment of Hypertrophic Scars and Keloids: Intralesional Cryosurgery." In Textbook on Scar Management. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_28.

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AbstractA novel intralesional cryosurgical needle is inserted into the hypertrophic scars and keloid (HSK). It is connected to a canister of liquid nitrogen, which causes the cryoprobe to freeze, thereby freezing the HSK from inside out.Following the cryo-treatment, the histomorphometric analysis demonstrated rejuvenation of the treated scar. The frozen tissue was devoid of proliferating cells and of mast cells whereas the number of blood vessels remained unaltered.The surface thermal history showed slow cooling and thawing rates as well as less pronounced end temperature, which is “friendly”

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Agolti, Mariela, and Lucrecia Solari. "Review of F-18 FDG PET/CT in Evaluating Response to Immunotherapy Treatment." In Beyond Becquerel and Biology to Precision Radiomolecular Oncology: Festschrift in Honor of Richard P. Baum. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-33533-4_2.

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AbstractIntroduction: Immunotherapy is a wide-spreading therapeutic resource in oncology. The therapy is guided to improve the patient’s immune response to cancer cells, on the basis of the concept of immune surveillance by activating both cell-mediated and humoral immunity to fight cancer. Immunomodulatory monoclonal antibody therapy utilizes preformed monoclonal antibodies directed against molecular targets to regulate T-cell activation. There are three mechanisms involved in this kind of therapy: antibodies directed against the programmed death protein 1 (PD-1)/programmed death receptor lig

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Zhang, Zuowen, Mingchang Li, and Jie Huang. "Dendritic Cell-Based Glioblastoma Vaccines: Advances and Challenges." In Challenge of Glioblastoma - From Pathology to Survival [Working Title]. IntechOpen, 2025. https://doi.org/10.5772/intechopen.1009185.

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Glioblastoma (GBM) is the most aggressive malignancy of the central nervous system. Despite advances in standard treatments such as surgery, radiotherapy, and chemotherapy, patients have a very poor prognosis. Tumor vaccines based on dendritic cells (DCs) provide a promising new approach for GBM treatment. DCs, as the most effective antigen-presenting cells, initiate adaptive immune responses by activating tumor-specific T cells. However, the immunosuppressive microenvironment of GBM (characterized by regulatory T cells, myeloid suppressor cells, and immunosuppressive factors) and the physical

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Kulavi, Sohini, Debajit Dhar, Karan Iyer, Arnab Kumar Ghosh, and Jaya Bandyopadhyay. "Unveiling the Potentials of Withania somnifera (L.) Dunal as a Precise Therapeutic Intervention Against Glioblastoma Multiforme." In Life as Basic Science: An Overview and Prospects for the Future [Volume: 1]. International Academic Publishing House (IAPH), 2024. http://dx.doi.org/10.52756/lbsopf.2024.e01.007.

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Glioblastoma multiforme (GBM) is the most severe and fatal form of brain tumor, leading to a poor survival rate in patients and making a significant contribution to cancer-related deaths. The typical approaches to treating GBM involve surgical procedures followed by chemotherapy, targeting molecular pathways involving receptors like Epidermal Growth Factor Receptor (EGFR, EGFRvIII) and Vascular Endothelial Growth Factor Receptor (VEGFR) to modulate various cell signaling pathways. However, the effectiveness of current GBM treatments is notably constrained. Withania somnifera (WS) (L.) Dunal, c

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Dubrovska, Anna, Mechthild Krause, and Michael Baumann. "Biological effect of radiotherapy on cancer cells." In Oxford Textbook of Cancer Biology, edited by Francesco Pezzella, Mahvash Tavassoli, and David J. Kerr. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198779452.003.0030.

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Radiation therapy is a mainstay for curative treatment of many types of tumours. The cure rate of radiation therapy depends on its ability to induce non-repairable DNA damage leading to cellular death or loss of proliferative capacity. In addition to clinical factors, efficacy of radiation therapy has been explained by the radiobiological concept of 4R parameters summarized by Rodney Withers in 1975, which include Repair of DNA damage, Repopulation, Redistribution of tumour cells in the cell cycle, and Reoxygenation. This chapter reviews the direct and indirect effects of irradiation on cancer

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Zhang, Boyang. "The Effect of Oxaliplatin on the Immunogenic Cell Death and Cell Apoptosis of Human Merkel Cell Cancerous Tumor." In Studies in Health Technology and Informatics. IOS Press, 2023. http://dx.doi.org/10.3233/shti230870.

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Oxaliplatin, as previously studied in the paper, is a derivative of Cisplatin that is effective in treating the Lewis Lung Carcinoma (LLC)4. As it can actively induce immunogenic cell death of the cancer cells, and result in apoptosis, which increases the therapeutic efficacy in the LLC cancer treatment.4 Merkel cell caner is a type of skin cancer that is rare but highly aggressive, with high metastasizing and reoccurring rate. In this study, we aim the determine the potential of Oxaliplatin to induce apoptosis and ICD in cancerous Merkel cell line MCC1, in associate with the PD-1 inhibitor Ni

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Luo, Guotian, Giuliana E. Salazar-Noratto, Esther Potier, and Hervé Petite. "Engineering Bone with Mesenchymal Stem Cells: Challenges and Obstacles." In Stem Cells and Regenerative Medicine. IOS Press, 2021. http://dx.doi.org/10.3233/bhr210011.

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Repair and reconstruction of large bone defects remain a significant challenge. Cell construct, containing mesenchymal stem cells (MSCs) and scaffold, is a promising strategy for addressing and treating major orthopedic clinical conditions. However, the design of an ideal cell construct for engineering bone faces two critical challenges (i) matching the scaffold degradation rate to that of new bone formation and (ii) preventing the massive cell death post-implantation (caused by disruption of oxygen and nutrient supply). We will hereby primarily focus on the challenge of survival of MSCs post-

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Boes, Dr Christopher J. "Adult polyglucosan body disease (APBD)." In Fifty Neurologic Cases From Mayo Clinic. Oxford University PressNew York, NY, 2004. http://dx.doi.org/10.1093/oso/9780195177442.003.0012.

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Abstract The sural nerve specimen demonstrated frequent polyglucosan bodies in axons, and an axillary skin biopsy specimen showed them in the luminal cells of apocrine glands. Muscle biopsy showed diastase-resistant, periodic acid-Schiff (PAS)-positive material in a small population of muscle fibers. Glycogen branching enzyme (GBE) activity from skin fibroblasts was markedly decreased at 178 units (normal, 1,300±390 units). These findings suggested the diagnosis of APBD. APBD is a rare neurologic disorder characterized by progressive upper and lower motor neuron signs, early urinary incontinen

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Sadik, Saabira Banu Sahubar, and Ashok Kumar Pandurangan. "A Review on Regulation of Mitophagy in Colorectal Cancer and Possible Drug Interventions." In Roles of Mitophagy in Cancer Regulation. IGI Global, 2025. https://doi.org/10.4018/979-8-3693-3836-0.ch006.

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Colorectal cancer (CRC) is a serious health issue affecting people worldwide. The cure or survival rate for colon cancer has not increased despite significant clinical breakthroughs. This review discusses the regulation of mitophagy in CRC and compiles natural products that modulate mitophagy signaling. Mitochondria supply energy to cells, and malfunctions in mitochondrial function impact redox regulation, cell homeostasis, bioenergetics, and cell death. Mitophagy, selectively removing damaged mitochondria, alters the metabolic environment of cancer cells and their interactions with tumor micr

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Conference papers on the topic "Cell death rate of gbm cells"

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Williams, Terry M. "The Mechanism of Action of Isothiazolone Biocides." In CORROSION 2006. NACE International, 2006. https://doi.org/10.5006/c2006-06090.

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Abstract Isothiazolone biocides have proven efficacy and performance for microbial control in a variety of industrial water treatment applications. Understanding the mechanism of action of industrial biocides is important in optimizing their use and combating resistance if encountered. Isothiazolones utilizes a two-step mechanism involving rapid inhibition (minutes) of growth and metabolism, followed by irreversible cell damage resulting in loss of viability (hours). Cells are inhibited by disruption of the metabolic pathways involving dehydrogenase enzymes. Critical physiological functions ar

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Saadatzadeh, Mohammad Reza, Khadijeh Bijangi Vishehsaraei, Haiyan Wang, Aaron Cohen-Gadol, Karen E. Pollok, and Ahmad R. Safa. "Abstract B18: Targeting histone deacetylase 6 (HDAC6) depresses proliferation and induces caspase-associated cell death in glioblastoma multiforme (GBM) cells and GBM stem cell-like spheroids." In Abstracts: AACR Special Conference: Advances in Brain Cancer Research; May 27-30, 2015; Washington, DC. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.brain15-b18.

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Bijangi-Vishehsaraei, Khadijeh, Mohammad R. Saadatzadeh, Haiyan Wang, et al. "Abstract 2267: Sulforaphane depresses proliferation and induces cell death in glioblastoma multiforme (GBM) cells, GBM stem cell-like spheroids, and tumor xenografts through modulation of multiple cell signaling pathways." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2267.

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Pineda-Medina, Alfredo. "In Vitro Evaluation of Adjuvant Therapy With Hyperthermia Induced by Irradiation (Nir) of AuNPs and Icg in Tumor Cells." In 5th World Conference on Chemistry and Chemical Engineering and 5th World Conference on Advanced Materials, Nanoscience and Nanotechnology. Eurasia Conferences, 2024. https://doi.org/10.62422/978-81-970328-7-5-012.

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Hyperthermia (HT) is a novel alternative to cancer treatment based on the increase of temperature between 40-43°C inducing selective death in tumor cells, facing cancer treatment limitations such as drug resistance. HT employs nanomaterials such as gold nanoparticles (AuNPs) with the capacity to absorb light at a wavelength of 600-800nm by near-infrared region (NIR) producing heat, allowing efficient penetration of light into the tumor without damaging near tissue and improving cellular absorption. This work aimed to evaluate the effect on cell viability of HT combined with 5-FU on SW620-GFP c

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Saadatzadeh, Mohammad Reza, Haiyan Wang, Jixin Ding, et al. "Abstract A26: Inhibition of MDM2 and AKT signaling networks synergize to activate Forkhead box O-class transcription factors and promote cell death in mutant p53 GBM cells." In Abstracts: AACR Special Conference: Advances in Brain Cancer Research; May 27-30, 2015; Washington, DC. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.brain15-a26.

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Li, Yuhui, Fen Wang, Yanyan Lu, and Hao Wang. "The Directional Freezing Effects on Biological Cells in a Microfluidic Cell Culture System." In ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASMEDC, 2009. http://dx.doi.org/10.1115/mnhmt2009-18301.

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Cryotherapy is a prospective also green method for malignant tumor treatment. At low temperature, the cell viability relates with the cooling rate, temperature threshold, freezing interface as well as ice formation. In this paper a series of directional freezing processes and cell responses in a culture microchip were experimentally investigated. The temperature in the microchip was manipulated by a thermoelectric cooler. The surviving cells, necrotic and apoptotic cells under different cryotreatment (duration of the freezing process, freeze-thaw cycle, post-culture et al) were stained and dis

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Patel, Heet. "Cellular Metabolism Therapy Slowing Growth Rate of Glioblastomas." In 27th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2023. https://doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.137_2023.

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Glioblastoma Multiforme (GBM), more commonly known as glioblastomas, are a form of specialized brain tumors called gliomas. Glioblastomas most commonly occur in glial cells of the central nervous system and the average age of diagnosis is 64. Treatment methods implemented currently are surgery of the removable masses followed by courses of chemotherapy and radiotherapy. These methods can only prolong the life span by a few months and as such, new research focused on tumor cell metabolism is being conducted to determine its impact on the progression of this tumor. Tumor masses, such as Glioblas

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Salmanzadeh, Alireza, Harsha Kittur, Michael B. Sano, et al. "Investigating Dielectrophoretic Signature of Mouse Ovarian Surface Epithelial Cells, Macrophages and Fibroblasts." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80872.

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Epithelial ovarian carcinomas are the fourth leading cause of death in women in the United States among all cancers and the leading cause of death from gynecological malignancies1. The main reason for this high rate of mortality is the inability to properly detect these carcinomas early. Investigations for diagnosing ovarian cancer in early stages have been hindered by two major obstacles: lack of adequate cell models to study different cancer stages and lack of a reliable technique to isolate these cancer cells from peritoneal fluid. In trying to solve the first challenge, Dr. Schmelz and col

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Shah, Amit K., Li-Jen Yuan, Peter A. Torzilli, and C. T. Christopher Chen. "Strain Is the Major Factor for Chondrocyte Death in Articular Cartilage Under Static Load." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43059.

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Several studies have shown that stress, strain, and stress/strain rate at certain levels can kill chondrocytes, but the major factor is unclear. The objective of this study was to determine the effects of strain and stress on chondrocyte death. Bovine cartilage explants (5 mm) at the age of 2 and 24 month were indented (3 mm) at 3.12, 6.25 and 12.5 MPa to reach a final strain of 15, 30, 45, 60 and 75%. Cell death in the center and on the edges of the indented region was assessed at 0, 3 and 7 days post-loading, and quantified using commercially available software. Our results showed cell death

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Sigler, James S. "Raw Materials and Processing Issues in the Development of Vascugel, a Cell Therapy for Vascular Disease." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2502.

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Abstract Vascular arterial disease is the most common cause of death in the United States. Cardiovascular surgery such as coronary artery bypass graft surgery and therapies such as angioplasty and stenting are the current standard of care. However, a large number of these procedures fail due to a form of arterial disease known as restenosis. Restenosis is the re-narrowing of the treated blood vessel following vessel wall injury resulting in decreased blood flow. This re-narrowing occurs in large part because the smooth muscle cells in the wall of the vessel proliferate after the vessel is dama

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Reports on the topic "Cell death rate of gbm cells"

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Dechow, Chad Daniel, M. Cohen-Zinder, Morris Soller, et al. Genotypes and phenotypes of telomere length in Holstein cattle, actors or reporters. United States-Israel Binational Agricultural Research and Development Fund, 2020. http://dx.doi.org/10.32747/2020.8134156.bard.

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Selection programs aiming at improving health and survival in cattle are complicated by low heritability estimates, the fact that true herd life and carcass quality is not known until the end of an animal's life, and that many health conditions manifest late in life. Young animals are now heavily favored in breeding programs because low generation intervals accelerate the rate of genetic progress, which means selection decisions must be made before phenotypic observation of health and survival is feasible. Moreover, profitability is compromised when livestock producers raise animals that fail

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Granot, David, Richard Amasino, and Avner Silber. Mutual effects of hexose phosphorylation enzymes and phosphorous on plant development. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7587223.bard.

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Research objectives 1) Analyze the combined effects of hexose phosphorylation and P level in tomato and Arabidopsis plants 2) Analyze the combined effects of hexose phosphorylation and P level in pho1 and pho2 Arabidopsis mutants 3) Clone and analyze the PHO2 gene 4) Select Arabidopsis mutants resistant to high and low P 5) Analyze the Arabidopsis mutants and clone the corresponding genes 6) Survey wild tomato species for growth characteristics at various P levels Background to the topic Hexose phosphorylating enzymes, the first enzymes of sugar metabolism, regulate key processes in plants suc

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