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Dissertations / Theses on the topic 'Cell receptors'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Ferletta, Maria. "The Laminins and their Receptors." Doctoral thesis, Uppsala University, Department of Cell and Molecular Biology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1771.

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<p>Basement membranes are thin extracellular sheets that surround muscle, fat and peripheral nerve cells and underlay epithelial and endothelial cells. Laminins are one of the main protein families of these matrices. Integrins and dystroglycan are receptors for laminins, connecting cells to basement membranes. Each laminin consists of three different chains, (α, β, γ). Laminin-1 (α1β1γ1) was the first laminin to be found and is the most frequently studied. Despite this, it was unclear where its α1 chain was expressed. A restricted distribution of the α1 chain in the adult epithelial basement m

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2

Eckl-Dorna, J. "How B cell receptors and Toll-like receptors collaborate in shaping B cell responses." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18762/.

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Antigen recognition by B cells results in their activation followed by specific antibody production. These events are initiated by antigen binding to their surface B cell receptors (BCR) which triggers both signalling and internalization of the receptor bound antigen to the endosome. However B cells also express features of the innate immune system such as Toll like receptors (TLRs), that can be located either on the surface of the cell or intracellularly where they recognize bacterial and viral nucleic acids. Engagement of these receptors within B cells is associated with enhancement of humor

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3

Betson, Martha Elizabeth. "Regulation of cell-cell adhesion in keratinocyes." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274930.

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4

Jorgenson, Rebecca L. "The innate immune response and toll-like receptors in the human endometrium." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/4178.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2005.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "December 2005" Includes bibliographical references.

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5

Jiang, Ning. "Kinetic analysis of Fcγ receptor and T cell receptor interacting with respective ligands". Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/26716.

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Low affinity Fcg receptor III (FcgRIII, CD16) triggers a variety of cellular events upon binding to the Fc portion of IgG. A real-time flow cytometry method was developed to measure the affinity and kinetics of such low affinity receptor/ligand interactions, which was shown as an easily operated yet powerful tool. Results revealed an unusual temperature dependence of reverse rate of CD16aTM dissociating from IgG. Except for a few studies using mammalian cell CD16s, most kinetics analyses use purified aglycosylated extracellular portion of the molecules, making it impossible to assess the impor

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6

Im, Jin Seon. "Molecular characterization of T cell receptors and non-MHC restricted T cell receptor binding peptides." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/284969.

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T cells recognize antigenic peptides presented by MHC molecules on antigen presenting cells (APC) through T cell receptors (TCRs). Since TCRs are very similar to antibodies in structure and genetics, TCRs might have the potential to bind free antigens as antibodies do. Here, peptides which bound TCRs irrespective of MHC molecules have been identified by screening "one-bead one-peptide" combinatorial libraries. Peptides: VRENAR, RTGNYV, GKMHFK, KDAVKR and RKPQAI bound recombinant Jurkat single chain T cell receptors (scTcrs). GKMHFK, KDAVKR and RKPQAI were also specific for natural TCRs on the

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7

Ihenetu, Kenneth. "Characterisation of cannabinoid receptors on immune cells and cell lines." Thesis, University of Hertfordshire, 2003. http://hdl.handle.net/2299/14124.

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Cannabinoids may inhibit immune cell function by modulating cytokine/chemokine release but the receptors mediating these events are poorly characterised. The aim of this thesis is to characterise cannabinoid receptors mediating cytokine/chemokine release from immune and inflammatory cells by measuring the effects of cannabinoids on cytokine release using ELISA technique. Apoptosis of inflammatory cells was also assessed by visual evaluation of cells treated with cannabinoids using a nuclear fluorochrome 4'6-diamidino-2 phenyl indole dihydrochloride (DAPI). Non-selective cannabinoid receptor ag

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8

Campbell, M.-A. "Functional receptors on B-cell membranes." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383704.

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9

Paramasivam, Anbalakan. "Regulation of immune cell P2X receptors." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612427.

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10

Hannan, S. B. "Cell surface mobility of GABAB receptors." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1335825/.

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Type-B γ-aminobutyric acid receptors (GABABRs) are important for mediating slow inhibition in the central nervous system and the kinetics of their internalisation and lateral mobility will be a major determinant of their signalling efficacy. Functional GABABRs require R1 and R2 subunit co-assembly, but how heterodimerisation affects the trafficking kinetics of GABABRs is unknown. Here, an α-bungarotoxin binding site (BBS) was inserted into the N-terminus of R2 to monitor receptor mobility in live cells. GABABRs are internalised via clathrin- and dynamin-dependent pathways and recruited to endo

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11

Gray, Phillip Neal. "Characterization of the membrane associated progesterone receptor (MAPR) homologues in Saccharomyces cervisiae and Arabidopsis thaliana." Diss., Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/25589.

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12

Kalogeropoulos, Michail. "Novel mechanisms of dendritic cell regulation by leukocyte immunoglobulin-like receptor B1." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=210082.

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Dendritic cells play an essential role in activating immune responses upon recognition of pathogens. This results in maturation and migration to the lymph nodes, where T cells are stimulated by upregulated antigen presentation, co-stimulation and cytokine secretion. DCs are also considered important in inhibiting inappropriate immune responses against self-peptides which could lead to the development of autoimmunity. This has been attributed to DCs that demonstrate inhibited co-stimulation and cytokine secretion. It has been previously shown that the continuous ligation of an immunomodulatory

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13

Burford, Neil Thornton. "Cell signalling in Chinese hamster ovary cells expressing recombinant muscarinic receptors." Thesis, University of Leicester, 1994. http://hdl.handle.net/2381/33575.

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Agonist stimulation of recombinant m1, m2, and m3 muscarinic receptors, expressed in Chinese hamster ovary (CHO) cells, was compared. Carbachol binding affinity, and its modification by cations, guanine nucleotides and PTX pretreatment, was compared in washed membrane preparations of each of the CHO cell clones. Functional responses, determined by carbachol stimulation, were: [35S]GTPS binding in membranes; Ins(l,4,5)P3 accumulation in intact cells; 45ca2+ release from permeabilized cells; and cAMP accumulation in intact cells. m2-Transfected CHO cells were found to couple to AC, mediating inh

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14

Burdon, Drew. "Cell growth regulation by muscarinic acetylcholine receptors." Thesis, University of Leicester, 2002. http://hdl.handle.net/2381/29932.

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The growth response of Chinese hamster ovary (CHO) cells to activation of recombinantly expressed G protein-coupled muscarinic M2 or M3 acetylcholine (ACh) receptors has been assessed. Activation of these receptors leads to divergent growth responses: M2 ACh receptor activation causes an increase in DNA synthesis, whereas M3 ACh receptor activation causes a dramatic inhibition of DNA synthesis. The M3 ACh receptor-mediated growth inhibition has been characterised, and shown to comprise a G1-phase cell cycle arrest, involving an increase in p21Cip1/Waf1 protein expression. Further, a receptor-m

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15

Lester, Robin D. "Hypoxia activated cell signaling receptors in cancer." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3297526.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed April 28, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 114-134).

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16

Abraham, Linda Ann. "Thrombin, protease receptors and bone cell function." Thesis, Royal Veterinary College (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287938.

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17

Joseph, Ansamma K. "DNA sequence analysis of T cell receptors." Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321849.

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18

Soper, David Michael. "Interleukin-2 receptor and T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8344.

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19

McLane, Jesica Mata. "Investigation of 1alpha,25-dihydroxy vitamin D3 membrane receptor ERp60 in adipocytes from male and female lean and obese mice." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31793.

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Thesis (M. S.)--Biomedical Engineering, Georgia Institute of Technology, 2010.<br>Committee Chair: Dr. Barbara Boyan; Committee Co-Chair: Dr. Zvi Schwartz; Committee Member: Dr. Hanjoong Jo. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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20

Siow, Lam. "ATP and P2Y1 nucleotide receptor in cortical neurons : localization, signal transduction and transcriptional regulation /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202006%20SIOW.

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21

Dagkalis, Athanasios. "CCR2 and CX3CR1 in monocyte trafficking in experimental autoimmune uveoretinitis." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24809.

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22

Williams, Tom E. "Adhesion of membrane-bound receptors and ligands : concurrent binding and the role of microtopology." Diss., Georgia Institute of Technology, 1998. http://hdl.handle.net/1853/17335.

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23

Prevo, Remko. "Characterisation of new Link superfamily Hyaluronan receptors." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275401.

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24

Hauser, Jannek. "Regulation of B cell development by antigen receptors." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40819.

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The developmental processes of lymphopoiesis generate mature B lymphocytes from hematopoietic stem cells through increasingly restricted intermediates. Networks of transcription factors regulate these cell fate choices and are composed of both ubiquitously expressed and B lineage-specific factors. E-protein transcription factors are encoded by the three genes E2A, E2-2 (SEF2-1), and HEB. The E2A gene is required for B cell development and encodes the alternatively spliced proteins E12 and E47. During B lymphocyte development, the cells have to pass several checkpoints verifying the functionali

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25

Yuan, Fang. "Cell Surface Recognitions by Viral and Immune Receptors." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491598.

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Cell surface recognition is an important interaction occurring between proteins on opposite cell surfaces and transmits signals that allow cells to adapt to their environment. Viruses utilise recognition for entering host cells, and the immune system may defend against numerous attacks from environment through these interactions, by generating a protective adaptive immune response. This thesis offers insight into cell surface recognition through both viral and immune system molecules. For virus research, West Nile virus receptor binding domain was refolded and crystallized. Structural informat

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26

Chang, C. "Human decidual NK cell receptors and their functions." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597450.

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In this thesis I have studied the possible receptors on decidual leukocytes which will bind to the HLA class I ligands on trophoblast. Of particular importance is the identity and function of the receptor for HLA-G as this molecule is only found on invading trophoblast cells. I have studied the expression, binding characteristics and functions of two possible HLA-G receptors, KIR2DL4 and ILT2. cDNA for these receptors was transfected into NK cell line, several functional assays were performed including cytotoxicity and cytokine production. The results showed the recognition of HLA-G by ILT2 an

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27

Melia, M. "Investigation of cell entry receptors used by morbillliviruses." Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432851.

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28

Summers, Andrea Eva. "Characterisation of nicotine receptors on immune cell lines." Thesis, University of Hertfordshire, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289604.

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29

Al-Lazikani, Bissan. "Canonical structures of immunoglobulins and T cell receptors." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624098.

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30

Border, Ellen Clare. "Structural and functional studies of cell surface receptors." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:907793da-3ba1-4a57-8bdb-c185aa84c28c.

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Receptor proteins on the surfaces of cells equip them to communicate with each other and to sense and interact with their environment. One receptor family, the αβ T-cell receptors (TCRs), allow T lymphocytes to detect and respond to pathogens via interactions with antigen-presenting major histocompatibility complex (MHC) molecules on target cells. A degree of TCR cross-reactivity (e.g. through structural similarity between peptide-MHC (pMHC) complexes) is essential to account for all possible pathogens, but can also lead to the misinterpretation of self antigens as foreign, and thereby elicit

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31

Bonyanian, Zeinab. "Adenosine Receptors And Endothelial Cell Mediated Wound Healing." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/367912.

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Impaired wound healing is a common and serious complication of diabetes mellitus causing an increased risk of infection and tissue damage. Chronic wounds associated with diabetes may be caused by peripheral neuropathy, vascular complications and alterations in immune function and contributes to non-traumatic amputations. Consequently, therapeutic management of wounds in diabetes is centred on infection control and stimulating revascularization. This research will focus on the latter and investigate the effects of high glucose on endothelial function with a view of finding new strategies to imp

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32

Parra, Eduardo. "Molecular basis for costimulation of human T lymphocytes." Lund : Lund University, 1998. http://books.google.com/books?id=SgFrAAAAMAAJ.

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33

Kautsky, Mikael B. "The role of retinoic acid receptors in oral epithelial differentiation /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/6395.

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34

Moody, Anne Marie. "T-cell receptor studies in myasthenia gravis." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337448.

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35

Tung, Kwok Kwan. "Functional roles of P2Y2 nucleotide receptor in the formation and maintenance of vertebrate neuromuscular junctions /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202003%20TUNG.

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Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003.<br>Includes bibliographical references (leaves 127-140). Also available in electronic version. Access restricted to campus users.

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36

Yuan, Xiaohui. "Characterization of the ligand-binding specificity and transcriptional properties of estrogen receptor homodimeric/heterodimeric complexes." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3036871.

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37

Carson, Bryan David. "Impaired T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8337.

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38

Ravi, Janani. "CROSSTALK BETWEEN CANNABINOID RECEPTORS AND EPIDERMAL GROWTH FACTOR RECEPTOR IN NON-SMALL CELL LUNG CANCER." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1426697196.

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39

Teixeira, de Matos Cristina. "Modulation of natural killer cell and T-cell functions by CD94/NKG2A receptors /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-846-0/.

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40

Slessareva, Janna Eugenievna. "Molecular mechanisms of G protein-receptor coupling." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2907.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains vi, 200 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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41

Ma, Hongzheng. "Molecular mechanisms of G protein-receptor coupling." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2978.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains viii, 264 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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42

Buhler, Marc McWilliams. "Genetics of the immune cell receptors TCRB and CCR5 in human disease." University of Sydney, 2003. http://hdl.handle.net/2123/601.

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Abstract Early in the evolution of the vertebrates it is thought that two genomic duplications occurred, providing a basis for the evolution in body plan and neural crest of very early vertebrates and substantive material for further evolution of various gene families such as those making up a number of components of the adaptive vertebrate immune system. While the bony fish possibly had another, genome duplications are not generally a feature of vertebrate evolution and indeed the appearance of an antigen-adaptive immune recognition system may have served to limit the size that various verteb

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43

Zhang, Min, and 張敏. "The role of B cell activating factor in B cell development and autoimmunity." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37659807.

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44

Conway, Ann Marie. "Growth factor receptor tyrosine kinase-, G-protein coupled receptor- and sphingolipid-dependent regulation of the extracellular signal-regulated kinase cascade in cultured airway smooth muscle cells." Thesis, University of Strathclyde, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366970.

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45

Asamaphan, Patawee. "Exploring the structure and function of MelLec, a C-type lectin-like receptor that recognises DHN melanin." Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=239859.

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46

Dorning, Ashley J. "The pharmacology, signalling and expression of the lipid-sensing receptor GPR92." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=201860.

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G protein-coupled receptors (GPCRs) are 7 transmembrane domain proteins capable of initiating cellular responses following ligand binding. GPR92 is expressed in the central nervous system (CNS) and is demonstrated to be involved in pain signalling via neurons of the spinal cord and dorsal root ganglion (DRG). Activated by the endogenous lipid lysophosphatidic acid (LPA), GPR92 is now considered the 5th LPA receptor. There remains controversy regarding GPR92 pharmacology however, as studies show another endogenous lipid, farnesyl pyrophosphate (FPP), also activates GPR92 with similar potency an

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47

Clark, Alexandra Elsie. "Characterisation of the C-type lectin-like receptor 1 (CLEC-1)." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=210080.

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48

Cheng, Wai, and 鄭蔚. "The relationship between peroxisome proliferator-activated receptors (PPARs) and cell proliferation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45010614.

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49

Hussein, Mohamed Osman. "Hormonal modulation of Leydig cell membrane luteinizing hormone receptors /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487267024995937.

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50

Ammoun, Sylwia. "Orexin Receptors in Recombinant CHO Cells : Signaling to Short- and Long-Term Cell Responses." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5890.

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