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Journal articles on the topic 'Cell uptake'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Zehra, Pınar Koc, Pınar Özcan Kara Pelin, Sezer Emel, Özcan Cengiz, Yaldız Mehmet, and Görür Kemal. "Squamous cell carcinoma associated granular cell tumor with progressive FDG accumulation." International Journal of Medical Reviews and Case Reports 3, no. 11 (2019): 777–78. https://doi.org/10.5455/IJMRCR.Granular-cell-tumor-FDG-uptake.

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Granular cell tumor is a usually benign rare tumor of middle age women with variable FDG uptake patterns. The case that we presented was the first in the literature as far as we know with presentation of two different concurrent pathologies and progressive FDG uptake. Since the case was considered unresectable the patients received further chemotherapy. The patients' PET/CT results showed progression under treatment.

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2

Xu, Hengyi, Zoraida P. Aguilar, Hua Wei, and Andrew Wang. "Cell Uptake of Nanoparticles." ECS Transactions 25, no. 31 (2019): 9–17. http://dx.doi.org/10.1149/1.3327198.

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3

Yanagawa, N., and O. D. Jo. "Intracellular acidification inhibits opposum kidney cell phosphate uptake." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 272, no. 6 (1997): R1904—R1911. http://dx.doi.org/10.1152/ajpregu.1997.272.6.r1904.

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The aim of our study is to examine the effect of intracellular pH (pHi) on inorganic phosphate (Pi) uptake by a proximal tubular cell line, the opposum kidney (OK) cells. The OK cell pHi (7.48 +/- 0.02; n = 12) was altered to levels between 6.5 and 8.5 by the high-K+ nigericin method, and cell uptakes were measured at 7.5 extracellular pH. It was found that pHi acidification suppressed Pi uptake with a decrease in maximal reaction rate, whereas alkalinization had no significant effect. Other Na(+)-dependent transport systems for glucose and amino acid were not affected by these pHi changes. Th

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4

Taher, Muhammad, Fadzilah Adibah Abdul Majid, and Mohamad Roji Sarmidi. "The Effect of Cinnamtannin B1 on Cell Proliferation and Glucose Uptake of 3T3-L1 Cells." Natural Product Communications 2, no. 1 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200112.

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The effects of cinnamtannin B1 on cell proliferation and glucose uptake of 3T3-L1 cells were examined. Cinnamtannin B1 promoted cell proliferation of 3T3-L1 adipocytes at a concentration range between 0.11-0.17 mM. The effect of cinnamtannin B1 on cellular 2-deoxy-D-[1-3H] glucose uptake in differentiated 3T3-L1 adipocytes, following treatment with a 0.11 mM concentration of cinnamtannin B1 for 15, 30 and 60 minutes, was an increase in the glucose uptake from a basal value to 702.0, 1111.0 and 2226.0 cpm, respectively (p<0.005). The comparable glucose uptakes with insulin treatment were 660

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Emoto, Akiko, Fumihiko Ushigome, Noriko Koyabu, et al. "H+-linked transport of salicylic acid, an NSAID, in the human trophoblast cell line BeWo." American Journal of Physiology-Cell Physiology 282, no. 5 (2002): C1064—C1075. http://dx.doi.org/10.1152/ajpcell.00179.2001.

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We investigated the transport of salicylic acid and l-lactic acid across the placenta using the human trophoblast cell line BeWo. We performed uptake experiments and measured the change in intracellular pH (pHi). The uptakes of [14C]salicylic acid andl-[14C]lactic acid were temperature- and extracellular pH-dependent and saturable at higher concentrations. Both uptakes were also reduced by FCCP, nigericin, and NaN3. Various nonsteroidal anti-inflammatory drugs (NSAIDs) strongly inhibited the uptake of l-[14C]lactic acid. Salicylic acid and ibuprofen noncompetitively inhibited the uptake ofl-[1

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6

Chen, Ran, Tatsiana A. Ratnikova, Matthew B. Stone, et al. "Cell uptake: Small 5/2010." Small 6, no. 5 (2010): NA. http://dx.doi.org/10.1002/smll.201090015.

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7

Moglia, Italo, Margarita Santiago, Simon Guerrero, Mónica Soler, Alvaro Olivera-Nappa, and Marcelo J. Kogan. "Enhanced Cellular Uptake of H-Chain Human Ferritin Containing Gold Nanoparticles." Pharmaceutics 13, no. 11 (2021): 1966. http://dx.doi.org/10.3390/pharmaceutics13111966.

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Gold nanoparticles (AuNP) capped with biocompatible layers have functional optical, chemical, and biological properties as theranostic agents in biomedicine. The ferritin protein containing in situ synthesized AuNPs has been successfully used as an effective and completely biocompatible nanocarrier for AuNPs in human cell lines and animal experiments in vivo. Ferritin can be uptaken by different cell types through receptor-mediated endocytosis. Despite these advantages, few efforts have been made to evaluate the toxicity and cellular internalization of AuNP-containing ferritin nanocages. In th

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8

Margovsky, A. I., R. S. A. Lord, A. C. Meek, and Y. V. Bobryshev. "Artery Wall Damage and Platelet Uptake from So-Called Atraumatic Arterial Clamps: An Experimental Study." Cardiovascular Surgery 5, no. 1 (1997): 42–47. http://dx.doi.org/10.1177/096721099700500109.

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A ‘traumatic’ clamps are routinely used to control arteries during reconstruction, but little is known about the arterial damage caused and the effects on platelet uptake. This experiment used sheep carotid arteries to correlate the degree of histologic damage observed with the level of indium-111-labelled platelet uptake in clamped arterial segments. Scanning electron microscopy and light microscopy enabled three degrees of injury to be recognized. In mild injuries, endothelial cell orientation was changed but local platelet uptake was little different from controls. In moderate injuries, the

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9

CPK, Cheung. "T Cells, Endothelial Cell, Metabolism; A Therapeutic Target in Chronic Inflammation." Open Access Journal of Microbiology & Biotechnology 5, no. 2 (2020): 1–6. http://dx.doi.org/10.23880/oajmb-16000163.

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The role of metabolic reprogramming in the coordination of the immune response has gained increasing consideration in recent years. Indeed, it has become clear that changes in the metabolic status of immune cells can alter their functional properties. During inflammation, stimulated immune cells need to generate sufficient energy and biomolecules to support growth, proliferation and effector functions, including migration, cytotoxicity and production of cytokines. Thus, immune cells switch from oxidative phosphorylation to aerobic glycolysis, increasing their glucose uptake. A similar metaboli

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10

Vorasubin, Nopawan, Quyen To Nguyen, Emilia Olson, Todd A. Aguilera, Tao Jiang, and Roger Y. Tsien. "Cell Penetrating Peptide Uptake by Human Tissue." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (2008): P35. http://dx.doi.org/10.1016/j.otohns.2008.05.116.

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Objective 1) Assess activatable cell penetrating peptide (ACPP) uptake by human tissue. 2) Compare ACPP uptake in normal and cancer tissue. Methods ACPPs are peptides that become activated for cellular uptake by cleavage in the presence of specific proteases. Fluorescently tagging ACPPs and designing a cleavage site recognized by proteases abundant in cancer allows for selective uptake and imaging. Cleavable ACPPs consist of L-amino acids linkers, while uncleavable linkers consist of corresponding D-isomers. To assess ACPP uptake by human tissue, we imaged freshly ressected surgical specimens

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11

Law, D., K. S. Hering-Smith, and L. L. Hamm. "Citrate transport in proximal cell line." American Journal of Physiology-Cell Physiology 263, no. 1 (1992): C220—C225. http://dx.doi.org/10.1152/ajpcell.1992.263.1.c220.

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Citrate uptake into kidney proximal tubules occurs via an apical dicarboxylate transporter and a poorly characterized process in the basolateral membrane. We used OK cells, a cell line derived from opossum kidney, to study citrate transport in proximal tubule-like cells. Citrate uptake into cell monolayers was studied using [14C]citrate with [3H]mannitol as a volume marker. Citrate uptake into these cells was sodium dependent and saturable with increasing concentrations of citrate. In contrast to previous models, citrate transport was altered minimally by changes in pH from 6.2 to 7.0 and incr

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12

Eiríksdottir, E., H. Myrberg, M. Hansen, and U. Langel. "Cellular Uptake of Cell-Penetrating Peptides." Drug Design Reviews - Online 1, no. 2 (2004): 161–73. http://dx.doi.org/10.2174/1567269043480636.

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13

Levin, P., T. Bistritzer, L. Hanukoglu, S. Max, and L. Roeder. "ACTH1-24Stimulates Muscle Cell Glucose Uptake." Hormone and Metabolic Research 22, no. 12 (1990): 608–11. http://dx.doi.org/10.1055/s-2007-1004984.

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14

Pistocchi, Rossella, Nello Bagni, and José A. Creus. "Polyamine Uptake in Carrot Cell Cultures." Plant Physiology 84, no. 2 (1987): 374–80. http://dx.doi.org/10.1104/pp.84.2.374.

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15

Morita, Aryan, Felipe P. Perona Martinez, Mayeul Chipaux, et al. "Cell Uptake of Lipid‐Coated Diamond." Particle & Particle Systems Characterization 36, no. 8 (2019): 1900116. http://dx.doi.org/10.1002/ppsc.201900116.

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16

Su, T. Z., C. D. Logsdon, and D. L. Oxender. "Chinese hamster ovary mRNA-dependent, Na(+)-independent L-leucine transport in Xenopus laevis oocytes." Molecular and Cellular Biology 12, no. 12 (1992): 5281–87. http://dx.doi.org/10.1128/mcb.12.12.5281-5287.1992.

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In freshly prepared uninjected folliculated oocytes, Na(+)-independent leucine uptake is mediated predominantly by a system L-like transport system. Removal of follicular cells, however, results in an irreversible loss of this transport activity. When total poly(A)+ mRNA derived from Chinese hamster ovary (CHO) cells was injected into prophase-arrested stage V or VI Xenopus laevis oocytes, enhanced expression of Na(+)-independent leucine transport was observed. The injected mRNAs associated with increased levels of leucine uptake were between 2 and 3 kb in length. The newly expressed leucine t

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17

Mitchell, A. M., S. W. Manley, E. J. Payne, and R. H. Mortimer. "Uptake of thyroxine in the human choriocarcinoma cell line JAR." Journal of Endocrinology 146, no. 2 (1995): 233–38. http://dx.doi.org/10.1677/joe.0.1460233.

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Abstract We have studied the uptake of 125I-thyroxine (125I-T4) in the human choriocarcinoma cell line JAR. Uptake of 125I-T4 was time-dependent, stereospecific and reversible, with a saturable component of 33% after 120 min of incubation. Kinetic analysis of the initial specific uptake rates indicated the presence of a single uptake process with a Michaelis constant of 59·4 ± 13·9 nm (n=12) and maximum velocity of 0·29 ± 0·06 pmol/min per mg protein. Uptake was dependent on intracellular energy as, in the presence of 2 mm potassium cyanide, saturable uptake was reduced to 60·6 ± 8·5% (n=4) of

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18

Yepes, Maria Monica, Andrés Felipe Herrera Ortiz, Valeria del Castillo, and Julian Rojas. "Clear cell renal cell carcinoma with high PSMA uptake." BMJ Case Reports 17, no. 4 (2024): e260372. http://dx.doi.org/10.1136/bcr-2024-260372.

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19

Nickel, Robert Sheppard, Elizabeth Seashore, Adina L. Alazraki, John T. Horan, Monica Bhatia, and Ann E. Haight. "Improved Splenic Function after Stem Cell Transplant for Sickle Cell Disease." Blood 124, no. 21 (2014): 3966. http://dx.doi.org/10.1182/blood.v124.21.3966.3966.

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Abstract Introduction: Splenic dysfunction is a critical complication of SCD that begins in early childhood and can cause fatal sepsis. Hematopoietic stem cell transplant (HSCT) is a proven cure for SCD, however, its long-term effect on the spleen in patients who had SCD is not well characterized. This information could be helpful to further inform medical professionals and families considering HSCT for SCD. Better understanding of the splenic function of patients after transplant for SCD could also provide important information regarding these patients' future risk of infection and other poss

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20

Phoaubon, Supathra, Kornkamon Lertsuwan, Jarinthorn Teerapornpuntakit, and Narattaphol Charoenphandhu. "Hepcidin induces intestinal calcium uptake while suppressing iron uptake in Caco-2 cells." PLOS ONE 16, no. 10 (2021): e0258433. http://dx.doi.org/10.1371/journal.pone.0258433.

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Abnormal calcium absorption and iron overload from iron hyperabsorption can contribute to osteoporosis as found in several diseases, including hemochromatosis and thalassemia. Previous studies in thalassemic mice showed the positive effects of the iron uptake suppressor, hepcidin, on calcium transport. However, whether this effect could be replicated in other conditions is not known. Therefore, this study aimed to investigate the effects of hepcidin on iron and calcium uptake ability under physiological, iron uptake stimulation and calcium uptake suppression. To investigate the potential mecha

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21

Ford, D. M., R. H. Dahl, C. A. Lamp, and B. A. Molitoris. "Apically and basolaterally internalized aminoglycosides colocalize in LLC-PK1 lysosomes and alter cell function." American Journal of Physiology-Cell Physiology 266, no. 1 (1994): C52—C57. http://dx.doi.org/10.1152/ajpcell.1994.266.1.c52.

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Aminoglycosides bind to apical and basolateral (BL) membranes of renal epithelial cells. However, little is known regarding differential uptake and intracellular processing after internalization across these distinct surface membrane domains. To examine these processes independently, LLC-PK1 cells were grown on porous filters, which allow selective access to both domains. Apical and BL membrane uptakes of gentamicin (0.5 mM), quantified using [3H]gentamicin, were linear from 2 to 24 h (r = 0.99). The 4-h apical gentamicin uptake was 667 +/- 59 pmol/mg protein, the BL 748 +/- 26 pmol/mg protein

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22

Hamzah, Rabab N., Karrer M. Alghazali, Alexandru S. Biris, and Robert J. Griffin. "Exosome Traceability and Cell Source Dependence on Composition and Cell-Cell Cross Talk." International Journal of Molecular Sciences 22, no. 10 (2021): 5346. http://dx.doi.org/10.3390/ijms22105346.

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Exosomes are small vesicles with an average diameter of 100 nm that are produced by many, if not all, cell types. Exosome cargo includes lipids, proteins, and nucleic acids arranged specifically in the endosomes of donor cells. Exosomes can transfer the donor cell components to target cells and can affect cell signaling, proliferation, and differentiation. Important new information about exosomes’ remote communication with other cells is rapidly being accumulated. Recent data indicates that the results of this communication depend on the donor cell type and the environment of the host cell. In

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23

Fujita, Yosuke, Tomoki Nagakura, Hiroyuki Uchino, Masato Inazu, and Tsuyoshi Yamanaka. "Functional Expression of Choline Transporters in Human Neural Stem Cells and Its Link to Cell Proliferation, Cell Viability, and Neurite Outgrowth." Cells 10, no. 2 (2021): 453. http://dx.doi.org/10.3390/cells10020453.

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Choline and choline metabolites are essential for all cellular functions. They have also been reported to be crucial for neural development. In this work, we studied the functional characteristics of the choline uptake system in human neural stem cells (hNSCs). Additionally, we investigated the effect of extracellular choline uptake inhibition on the cellular activities in hNSCs. We found that the mRNAs and proteins of choline transporter-like protein 1 (CTL1) and CTL2 were expressed at high levels. Immunostaining showed that CTL1 and CTL2 were localized in the cell membrane and partly in the

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24

Shinada, Mitsuhiro, Masashi Takahashi, Chika Igarashi, et al. "64Cu2+ Complexes of Tripodal Amine Ligands’ In Vivo Tumor and Liver Uptakes and Intracellular Cu Distribution in the Extrahepatic Bile Duct Carcinoma Cell Line TFK-1: A Basic Comparative Study." Pharmaceuticals 17, no. 7 (2024): 820. http://dx.doi.org/10.3390/ph17070820.

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Copper (Cu) is a critical element for cancer cell proliferation and considerably accumulates in the nucleus. 64Cu2+ is an anticancer radiopharmaceutical that targets the copper requirement of cancer cells. However, intravenously injected 64Cu2+ ions primarily accumulate in the liver. Ligand complexation of 64Cu2+ may be a promising method for increasing tumor delivery by reducing liver uptake. In this study, we used three tripodal amine ligands [tris(2-aminoethyl)amine (Tren), diethylenetriamine (Dien), and tris(2-pyridylmethyl)amine (TPMA)] to enclose 64Cu2+ ions and compared their in vivo tu

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Chothe, Paresh, Nagendra Singh, and Vadivel Ganapathy. "Evidence for two different broad-specificity oligopeptide transporters in intestinal cell line Caco-2 and colonic cell line CCD841." American Journal of Physiology-Cell Physiology 300, no. 6 (2011): C1260—C1269. http://dx.doi.org/10.1152/ajpcell.00299.2010.

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Recently the existence of two different Na+-coupled oligopeptide transport systems has been described in mammalian cells. These transport systems are distinct from the previously known H+/peptide cotransporters PEPT1 and PEPT2, which transport only dipeptides and tripeptides. To date, the only peptide transport system known to exist in the intestine is PEPT1. Here we investigated the expression of the Na+-coupled oligopeptide transporters in intestinal cell lines, using the hydrolysis-resistant synthetic oligopeptides deltorphin II and [d-Ala2,d-Leu5]enkephalin (DADLE) as model substrates. Cac

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van der Putten, HH, BJ Joosten, PH Klaren, and ME Everts. "Uptake of tri-iodothyronine and thyroxine in myoblasts and myotubes of the embryonic heart cell line H9c2(2-1)." Journal of Endocrinology 175, no. 3 (2002): 587–96. http://dx.doi.org/10.1677/joe.0.1750587.

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Uptake of tri-iodothyronine (T(3)) was compared with that of thyroxine (T(4)) in the embryonic heart cell line H9c2 (2-1). These cells propagate as myoblasts and form differentiated myotubes upon reduction of the serum concentration, as indicated by a 31-fold increase in creatine kinase activity. Protein and DNA content per well were around 2-fold higher in myotubes than in myoblasts. When expressed per well, T(3) and T(4) uptake were, compared with myoblasts, 1.9- to 2-fold and 3.1- to 4-fold higher in myotubes respectively. On the other hand, the characteristics of T(3) and T(4) uptake were

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27

Petersen, Fernanda C., Lin Tao, and Anne A. Scheie. "DNA Binding-Uptake System: a Link between Cell-to-Cell Communication and Biofilm Formation." Journal of Bacteriology 187, no. 13 (2005): 4392–400. http://dx.doi.org/10.1128/jb.187.13.4392-4400.2005.

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ABSTRACT DNA has recently been described as a major structural component of the extracellular matrix in biofilms. In streptococci, the competence-stimulating peptide (CSP) cell-to-cell signal is involved in competence for genetic transformation, biofilm formation, and autolysis. Among the genes regulated in response to the CSP are those involved in binding and uptake of extracellular DNA. We show in this study that a functional DNA binding-uptake system is involved in biofilm formation. A comGB mutant of Streptococcus mutans deficient in DNA binding and uptake, but unaffected in signaling, sho

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28

Morrison, R. F., and E. R. Seidel. "Cell spreading and the regulation of ornithine decarboxylase." Journal of Cell Science 108, no. 12 (1995): 3787–94. http://dx.doi.org/10.1242/jcs.108.12.3787.

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The aim of this study was to investigate the effect of cell spreading on the induction of ornithine decarboxylase and the rate of putrescine uptake in anchorage-dependent and anchorage-independent cells. Plating non-transformed IEC-6 epithelial cells at high versus low cell density restricted cell spreading from 900 microns 2 to approximately 140 microns 2, blunted the transient induction of ornithine decarboxylase activity from 202 to 32 pmol 14CO2/mg protein per hour and reduced the rate of [14C] putrescine uptake from 46 to 23 pmol/10(5) cells per hour. The mean spreading area of the cell p

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29

Delvaux, M., M. J. Bastie, J. Chentoufi, E. J. Cragoe, N. Vaysse, and A. Ribet. "Amiloride and analogues inhibit Na(+)-H+ exchange and cell proliferation in AR42J pancreatic cell line." American Journal of Physiology-Gastrointestinal and Liver Physiology 259, no. 5 (1990): G842—G849. http://dx.doi.org/10.1152/ajpgi.1990.259.5.g842.

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To study the relation between activation of the Na(+)-H+ antiporter and gastrointestinal cell proliferation, we characterized this antiporter in a pancreatic cell line (AR42J) and studied the effects of mitogenic and nonmitogenic agents as well as those of Na(+)-H+ exchange blocking agents on DNA synthesis. Characteristics of amiloride-sensitive Na+ uptake were those of the Na(+)-H+ exchanger: 1) Na+ uptake was increased by intracellular acidification and depended on external [Na+] and pH; 2) concentrations for half-maximal inhibition (IC50) of Na+ uptake (3 mM [Na+] in medium) were 40 nM 5-(N

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30

Chen, Ruohua, Xiang Zhou, Gang Huang, and Jianjun Liu. "Fructose 1,6-Bisphosphatase 1 Expression Reduces 18F-FDG Uptake in Clear Cell Renal Cell Carcinoma." Contrast Media & Molecular Imaging 2019 (January 6, 2019): 1–6. http://dx.doi.org/10.1155/2019/9463926.

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Purpose. To determine the relationship between fructose 1,6-bisphosphatase 1 (FBP1) expression and fluorine 18 (18F) fluorodeoxyglucose (FDG) uptake in patients with clear cell renal cell carcinoma (ccRCC), and to investigate how 18F-FDG uptake and FBP1 expression are related to tumor metabolism and tumor differentiation grade. Materials and Methods. A total of 54 patients with ccRCC underwent 18F-FDG combined positron emission tomography and computed tomography (PET/CT) before tumor resection. The maximum standardized uptake value (SUVmax) for the primary tumor was calculated from the 18F-FDG

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Rhainds, David, and Louise Brissette. "Low density lipoprotein uptake: holoparticle and cholesteryl ester selective uptake." International Journal of Biochemistry & Cell Biology 31, no. 9 (1999): 915–31. http://dx.doi.org/10.1016/s1357-2725(99)00046-1.

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Ibarra, Kristie D., and Julie K. Pfeiffer. "Reduced Ribavirin Antiviral Efficacy via Nucleoside Transporter-Mediated Drug Resistance." Journal of Virology 83, no. 9 (2009): 4538–47. http://dx.doi.org/10.1128/jvi.02280-08.

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ABSTRACT Treatment for hepatitis C virus infection currently consists of pegylated interferon and ribavirin (RBV), a nucleoside analog. Although RBV clearly plays a role in aiding the treatment response, its antiviral mechanism is unclear. Regardless of the specific mechanism of RBV, we hypothesize that differences in levels of cellular uptake of RBV may affect antiviral efficacy and treatment success and that cells may become RBV resistant through reduced uptake. We monitored RBV uptake in various cell lines and determined the effect of uptake capacity on viral replication. RBV-resistant cell

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Simpson, S. J. "Unintentional Uptake." Science Signaling 1, no. 18 (2008): ec171-ec171. http://dx.doi.org/10.1126/stke.118ec171.

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Podolsky, Michael J., Deepti Gupta, Arnold Ha, et al. "Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation." American Journal of Physiology-Lung Cellular and Molecular Physiology 315, no. 3 (2018): L360—L370. http://dx.doi.org/10.1152/ajplung.00144.2018.

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Although extensive work has delineated many of the mechanisms of extracellular matrix (ECM) production, far less is known about pathways that regulate ECM degradation. This is particularly true of cellular internalization and degradation of matrix, which play an underappreciated role in ECM metabolism and lung fibrosis. For example, genetic perturbation of this pathway leads to exacerbated fibrosis in experimental animal models. In this work, we present the results of an unbiased screen of Drosophila phagocytes that yielded multiple genes that, when silenced, led to increased collagen uptake.

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Worthington, Mark T., Steven M. Cohn, Suzanne K. Miller, Roger Qi Luo, and Carl L. Berg. "Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines." American Journal of Physiology-Gastrointestinal and Liver Physiology 280, no. 6 (2001): G1172—G1177. http://dx.doi.org/10.1152/ajpgi.2001.280.6.g1172.

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Heme is the most bioavailable form of dietary iron and a component of many cellular proteins. Controversy exists as to whether heme uptake occurs via specific transport mechanisms or passive diffusion. The aims of this study were to quantify cellular heme uptake with a fluorescent heme analog and to determine whether heme uptake is mediated by a heme transporter in intestinal and hepatic cell lines. A zinc-substituted porphyrin, zinc mesoporphyrin (ZnMP), was validated as a heme homolog in uptake studies of intestinal (Caco-2, I-407) and hepatic (HepG2) cell lines. Uptake experiments to determ

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Ohrui, T., W. Skach, M. Thompson, J. Matsumoto-Pon, C. Calayag, and J. H. Widdicombe. "Radiotracer studies of cystic fibrosis transmembrane conductance regulator expressed in Xenopus oocytes." American Journal of Physiology-Cell Physiology 266, no. 6 (1994): C1586—C1593. http://dx.doi.org/10.1152/ajpcell.1994.266.6.c1586.

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We measured fluxes of radiotracers in Xenopus oocytes expressing the cystic fibrosis transmembrane conductance regulator (CFTR). Addition of adenosine 3',5'-cyclic monophosphate (cAMP)-elevating agents [forskolin and 3-isobutyl-1-methylxanthine (I/F)] led to large increases in uptake of 36Cl, 125I, and 82Br into oocytes expressing wild-type CFTR or delta F508 CFTR but not sham-injected oocytes. I/F also stimulated halide efflux from CFTR and delta F508 oocytes in the sequence Cl > Br > I. cAMP-induced increases in 36Cl efflux from delta F508 oocytes were approximately 20% of those in CFT

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Męczyńska-Wielgosz, Sylwia, Katarzyna Sikorska, Malwina Czerwińska, Lucyna Kapka-Skrzypczak, and Marcin Kruszewski. "Uptake and Toxicity of Polystyrene NPs in Three Human Cell Lines." International Journal of Molecular Sciences 26, no. 10 (2025): 4783. https://doi.org/10.3390/ijms26104783.

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Internalization of nanoparticles (NPs), including nanoplastic, is one of the key factors determining their toxicity. In this work, we studied the toxicity and mechanisms of the uptake of model fluorescent polystyrene NPs (PS NPs) of three different sizes (30, 50, and 100 nm) in three human cancer cells lines; two originated from gut tissue (HT-29 and Caco-2) and one originated from liver tissue (Hep G2). Toxicity was measured by Neutral Red Assay (NRU), whereas mechanisms of uptake were studied using flow cytometry and different uptake inhibitors. The toxicity of the studied NPs followed a gen

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Sathekge, M. M., and R. P. Clauss. "Tc99m Diphosphonate imaging: Giant cell tumours on MDP scanning." South African Journal of Radiology 1, no. 3 (1996): 38–40. http://dx.doi.org/10.4102/sajr.v1i3.1606.

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Ten patients with histologically proven giant cell tumour (biopsy) were imaged with 3-phase bone scanning, using 99m Tc-MDP. The perfusion (Phase I) and uptake (Phase III) were compared to the normal contralateral side and the rest of the skeleton was inspected for other abnormalities. Ninety per cent of lesions showed a doughnut-type pattern of uptake and presented with moderately increased perfusion (2.9 normal ± 0.7) and markedly increased uptake of tracer (7.5 normal ± 1.4). The patient with diffuse uptake had a pathological fracture.

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Petzinger, E., N. Muller, W. Follmann, J. Deutscher, and R. K. Kinne. "Uptake of bumetanide into isolated rat hepatocytes and primary liver cell cultures." American Journal of Physiology-Gastrointestinal and Liver Physiology 256, no. 1 (1989): G78—G86. http://dx.doi.org/10.1152/ajpgi.1989.256.1.g78.

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Uptake of bumetanide into rat liver cells was investigated using isolated hepatocytes and primary cell cultures. The kinetics of [3H]-bumetanide uptake revealed two saturable components in addition to an unsaturable component. Saturable bumetanide uptake consists of a high-affinity, sodium-dependent uptake and a low-affinity transport system. Bumetanide uptake into isolated rat hepatocytes is energy dependent and temperature sensitive. At low temperatures, bumetanide uptake is due to diffusion with a permeability coefficient of 1.16 x 10(-6) cm/s. In primary liver cell cultures, uptake of bume

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40

de Boer, Isa, Ceri J. Richards, and Christoffer Åberg. "Simultaneous Exposure of Different Nanoparticles Influences Cell Uptake." Pharmaceutics 14, no. 1 (2022): 136. http://dx.doi.org/10.3390/pharmaceutics14010136.

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Drug delivery using nano-sized carriers holds tremendous potential for curing a range of diseases. The internalisation of nanoparticles by cells, however, remains poorly understood, restricting the possibility for optimising entrance into target cells, avoiding off-target cells and evading clearance. The majority of nanoparticle cell uptake studies have been performed in the presence of only the particle of interest; here, we instead report measurements of uptake when the cells are exposed to two different types of nanoparticles at the same time. We used carboxylated polystyrene nanoparticles

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Viertl, D., F. Perillo-Adamer, P. A. André, et al. "18F-FLT and 125I-IdUrd uptake increase in human tumour cell lines induced by the thymidylate synthase inhibitor FdUrd." Nuklearmedizin 51, no. 05 (2012): 163–69. http://dx.doi.org/10.3413/nukmed-0459-12-01.

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Summary Aim: 5-fluoro-2′-deoxyuridine (FdUrd) depletes the endogenous 5′-deoxythymidine triphosphate (dTTP) pool. We hypothesized whether uptake of exogenous dThd analogues could be favoured through a feedback enhanced salvage pathway and studied the FdUrd effect on cellular uptake of 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) and 5-125I-iodo-2′-deoxyuridine (125I-IdUrd) in different cancer cell lines in parallel. Methods: Cell uptake of 18F-FLT and 125I-IdUrd was studied in 2 human breast, 2 colon cancer and 2 glioblastoma lines. Cells were incubated with/without 1 μmol/l FdUrd for 1 h and, af

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Waseem, Tayab C., Breanne Gjurich, Matthew J. Butcher, Alina Moriarty, William Coles Keeter, and Elena Galkina. "Dampening the B Cell Response, a modified lipid story." Journal of Immunology 200, no. 1_Supplement (2018): 107.15. http://dx.doi.org/10.4049/jimmunol.200.supp.107.15.

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Abstract Atherosclerosis is a multifaceted chronic inflammatory disease characterized by the accumulation of modified low density lipoproteins (mLDL) and immune cells in the aortic wall leading to vascular dysfunction. Uptake of mLDL by macrophages (MF) and the formation of foam cells are key events in the induction of atherosclerosis. Our data shows that B cells can also uptake acetylated and oxidized LDL (acLDL and oxLDL, respectively), but the functional consequences of this uptake are currently not well-understood. The transcriptional profiles of sorted B cells that took up acLDL in vivo b

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Sato, Toshinori, Hajime Miyaguchi, and Yoshio Okahata. "Cell uptake of albumin with synthetic glycolipid." Drug Delivery System 10, no. 3 (1995): 199–200. http://dx.doi.org/10.2745/dds.10.199.

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Kusoglu, Ahmet, Anthony Kwong, Kyle T. Clark, Haluna P. Gunterman, and Adam Z. Weber. "Water Uptake of Fuel-Cell Catalyst Layers." Journal of The Electrochemical Society 159, no. 9 (2012): F530—F535. http://dx.doi.org/10.1149/2.031209jes.

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Wang, Jing, Lixin Liu, Wen Zhu, Yongming Chen, and Chun Wang. "Cancer Cell Uptake of Polymer Hydrogel Nanotubes." Journal of Biomedical Nanotechnology 10, no. 11 (2014): 3329–36. http://dx.doi.org/10.1166/jbn.2014.1923.

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Vila, M., M. T. Portolés, P. A. A. P. Marques, et al. "Cell uptake survey of pegylated nanographene oxide." Nanotechnology 23, no. 46 (2012): 465103. http://dx.doi.org/10.1088/0957-4484/23/46/465103.

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GARBO, GRETA M., RICK W. KECK, STEVEN H. SELMAN, and MARTHA KREIMER-BIRN BAUM. "Hematoporphyrin Derivative Uptake and Tumor Cell Density." Annals of the New York Academy of Sciences 514, no. 1 Mechanisms of (1987): 328–29. http://dx.doi.org/10.1111/j.1749-6632.1987.tb48789.x.

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Elsworth, Brendan, Caroline D. Keroack, and Manoj T. Duraisingh. "Elucidating Host Cell Uptake by Malaria Parasites." Trends in Parasitology 35, no. 5 (2019): 333–35. http://dx.doi.org/10.1016/j.pt.2019.03.005.

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Ohkubo, Satoko, Koichi Nagata, and Norimichi Nakahata. "Adenosine uptake-dependent C6 cell growth inhibition." European Journal of Pharmacology 577, no. 1-3 (2007): 35–43. http://dx.doi.org/10.1016/j.ejphar.2007.08.025.

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Winslow, Robert M. "A model for red cell O2 uptake." International Journal of Clinical Monitoring and Computing 2, no. 2 (1985): 81–93. http://dx.doi.org/10.1007/bf02916236.

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