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Journal articles on the topic 'Cellular Delivery - Anionic Nanoparticles'

Author: Grafiati

Published: 7 September 2023

Last updated: 31 July 2025

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1

Maity, Amit Ranjan, and Nikhil R. Jana. "Chitosan−Cholesterol-Based Cellular Delivery of Anionic Nanoparticles." Journal of Physical Chemistry C 115, no. 1 (2010): 137–44. http://dx.doi.org/10.1021/jp108828c.

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Xu, Zhi Ping, and G. Q. (Max) Lu. "Layered double hydroxide nanomaterials as potential cellular drug delivery agents." Pure and Applied Chemistry 78, no. 9 (2006): 1771–79. http://dx.doi.org/10.1351/pac200678091771.

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This paper briefly reviews the recent progress in using layered double hydroxide (LDH) nanomaterials as cellular delivery agents. The advantages of LDHs as cellular delivery agents are summarized, and the processes of interaction/de-intercalation of anionic drugs (genes) into/from LDH nanoparticles are discussed. Then the cellular delivery of LDH-drug (gene) nanohybrids and subsequent intracellular processes are presumably proposed. At the end, some challenges and remarks for efficient delivery of drugs (genes) via LDH nanoparticles are provided to the best of our knowledge.

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Choi, Soo-Jin, Jae-Min Oh, Taeun Park, and Jin-Ho Choy. "Cellular Toxicity of Inorganic Hydroxide Nanoparticles." Journal of Nanoscience and Nanotechnology 7, no. 11 (2007): 4017–20. http://dx.doi.org/10.1166/jnn.2007.085.

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Layered double hydroxides (LDHs), anionic clays, have attracted increasing interest as nanovehicles for delivering genes, drugs, and bio-active molecules into cells. However, no attempts have been made to evaluate the potential undesirable effects of LDH nanoparticles. The cytotoxicity of LDHs with different chemical compositions (ZnAl- and MgAl-LDH) was systematically evaluated in various cell types, such as human normal cells, carcinoma cells, and red blood cells, by measuring cell viability, cell proliferation, membrane damage, and hemolytic effect. No significant cytotoxic effects could be

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Choi, Soo-Jin, Jae-Min Oh, Taeun Park, and Jin-Ho Choy. "Cellular Toxicity of Inorganic Hydroxide Nanoparticles." Journal of Nanoscience and Nanotechnology 7, no. 11 (2007): 4017–20. http://dx.doi.org/10.1166/jnn.2007.18081.

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Layered double hydroxides (LDHs), anionic clays, have attracted increasing interest as nanovehicles for delivering genes, drugs, and bio-active molecules into cells. However, no attempts have been made to evaluate the potential undesirable effects of LDH nanoparticles. The cytotoxicity of LDHs with different chemical compositions (ZnAl- and MgAl-LDH) was systematically evaluated in various cell types, such as human normal cells, carcinoma cells, and red blood cells, by measuring cell viability, cell proliferation, membrane damage, and hemolytic effect. No significant cytotoxic effects could be

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Berger, Eric, Dalibor Breznan, Sandra Stals, et al. "Cytotoxicity assessment, inflammatory properties, and cellular uptake of Neutraplex lipid-based nanoparticles in THP-1 monocyte-derived macrophages." Nanobiomedicine 4 (January 1, 2017): 184954351774625. http://dx.doi.org/10.1177/1849543517746259.

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Current antiretroviral drugs used to prevent or treat human immunodeficiency virus type 1 (HIV-1) infection are not able to eliminate the virus within tissues or cells where HIV establishes reservoirs. Hence, there is an urgent need to develop targeted delivery systems to enhance drug concentrations in these viral sanctuary sites. Macrophages are key players in HIV infection and contribute significantly to the cellular reservoirs of HIV because the virus can survive for prolonged periods in these cells. In the present work, we investigated the potential of the lipid-based Neutraplex nanosystem

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Tsai, Li-Hui, Chia-Hsiang Yen, Hao-Ying Hsieh, and Tai-Horng Young. "Doxorubicin Loaded PLGA Nanoparticle with Cationic/Anionic Polyelectrolyte Decoration: Characterization, and Its Therapeutic Potency." Polymers 13, no. 5 (2021): 693. http://dx.doi.org/10.3390/polym13050693.

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Optimized Doxorubicin hydrochloride (DOX) loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (DPN) were prepared by controlling the water/oil distribution of DOX at different pH solutions and controlling the electrostatic interaction between DOX and different terminated-end PLGAs. Furthermore, cationic polyethylenimine (PEI) and anionic poly (acrylic acid) (PAA) were alternately deposited on DPN surface to form PEI-DPN (IDPN) and PAA-PEI-DPN (AIDPN) to enhance cancer therapy potency. Compared to DPN, IDPN exhibited a slower release rate in physiological conditions but PEI was demonstrat

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Rotan, Olga, Katharina N. Severin, Simon Pöpsel, et al. "Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles." Beilstein Journal of Nanotechnology 8 (February 7, 2017): 381–93. http://dx.doi.org/10.3762/bjnano.8.40.

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The efficient intracellular delivery of (bio)molecules into living cells remains a challenge in biomedicine. Many biomolecules and synthetic drugs are not able to cross the cell membrane, which is a problem if an intracellular mode of action is desired, for example, with a nuclear receptor. Calcium phosphate nanoparticles can serve as carriers for small and large biomolecules as well as for synthetic compounds. The nanoparticles were prepared and colloidally stabilized with either polyethyleneimine (PEI; cationic nanoparticles) or carboxymethyl cellulose (CMC; anionic nanoparticles) and loaded

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Uto, Tomofumi, Takami Akagi, Mitsuru Akashi, and Masanori Baba. "Induction of Potent Adaptive Immunity by the Novel Polyion Complex Nanoparticles." Clinical and Vaccine Immunology 22, no. 5 (2015): 578–85. http://dx.doi.org/10.1128/cvi.00080-15.

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ABSTRACTThe development of effective and simple methods of vaccine preparation is desired for the prophylaxis and treatment of a variety of infectious diseases and cancers. We have created novel polyion complex (PIC) nanoparticles (NPs) composed of amphiphilic anionic biodegradable poly(γ-glutamic acid) (γ-PGA) and cationic polymers as a vaccine adjuvant. PIC NPs can be prepared by mixing γ-PGA-graft-l-phenylalanine ethylester (γ-PGA-Phe) polymer with cationic polymer in phosphate-buffered saline. We examined the efficacy of PIC NPs for antigen delivery and immunostimulatory activityin vitroan

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Tukova, Anastasiia, Inga Christine Kuschnerus, Alfonso Garcia-Bennett, Yuling Wang, and Alison Rodger. "Gold Nanostars with Reduced Fouling Facilitate Small Molecule Detection in the Presence of Protein." Nanomaterials 11, no. 10 (2021): 2565. http://dx.doi.org/10.3390/nano11102565.

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Gold nanoparticles have the potential to be used in biomedical applications from diagnostics to drug delivery. However, interactions of gold nanoparticles with different biomolecules in the cellular environment result in the formation of a “protein corona”—a layer of protein formed around a nanoparticle, which induces changes in the properties of nanoparticles. In this work we developed methods to reproducibly synthesize spheroidal and star-shaped gold nanoparticles, and carried out a physico-chemical characterization of synthesized anionic gold nanospheroids and gold nanostars through transmi

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Cotta, Karishma Berta, Sarika Mehra, and Rajdip Bandyopadhyaya. "pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages." Beilstein Journal of Nanotechnology 12 (October 7, 2021): 1127–39. http://dx.doi.org/10.3762/bjnano.12.84.

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Nanoparticle deployment in drug delivery is contingent upon controlled drug loading and a desired release profile, with simultaneous biocompatibility and cellular targeting. Iron oxide nanoparticles (IONPs), being biocompatible, are used as drug carriers. However, to prevent aggregation of bare IONPs, they are coated with stabilizing agents. We hypothesize that, zwitterionic drugs like norfloxacin (NOR, a fluoroquinolone) can manifest dual functionality – nanoparticle stabilization and antibiotic activity, eliminating the need of a separate stabilizing agent. Since these drugs have different c

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Kont, Ayse, Monique C. P. Mendonça, Michael F. Cronin, Mary R. Cahill, and Caitriona M. O’Driscoll. "Co-Formulation of Amphiphilic Cationic and Anionic Cyclodextrins Forming Nanoparticles for siRNA Delivery in the Treatment of Acute Myeloid Leukaemia." International Journal of Molecular Sciences 23, no. 17 (2022): 9791. http://dx.doi.org/10.3390/ijms23179791.

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Non-viral delivery of therapeutic nucleic acids (NA), including siRNA, has potential in the treatment of diseases with high unmet clinical needs such as acute myeloid leukaemia (AML). While cationic biomaterials are frequently used to complex the nucleic acids into nanoparticles, attenuation of charge density is desirable to decrease in vivo toxicity. Here, an anionic amphiphilic CD was synthesised and the structure was confirmed by Fourier-transform infrared spectroscopy (FT-IR), Nuclear Magnetic Resonance (NMR), and high-resolution mass spectrometry (HRMS). A cationic amphiphilic cyclodextri

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Tripathi, R. M., Sun-Young Yoon, Dohee Ahn, and Sang J. Chung. "Facile Synthesis of Triangular and Hexagonal Anionic Gold Nanoparticles and Evaluation of Their Cytotoxicity." Nanomaterials 9, no. 12 (2019): 1774. http://dx.doi.org/10.3390/nano9121774.

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Comprehension of the shape-dependent properties of gold nanoparticles (AuNPs) could benefit the advancements in cellular uptake efficiency. Spherical AuNPs have generally been used for drug delivery, and recent research has indicated that the cellular uptake of triangular AuNPs was higher than that of spherical ones. Previous reports have also revealed that chemically synthesized AuNPs were cytotoxic. Therefore, we have developed a facile, cost-effective, and environmentally friendly method for synthesizing triangular and hexagonal anionic AuNPs. The zeta potential of the synthesized AuNPs was

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Guagliardo, Roberta, Pieterjan Merckx, Agata Zamborlin, et al. "Nanocarrier Lipid Composition Modulates the Impact of Pulmonary Surfactant Protein B (SP-B) on Cellular Delivery of siRNA." Pharmaceutics 11, no. 9 (2019): 431. http://dx.doi.org/10.3390/pharmaceutics11090431.

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Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by various extra- and intracellular barriers, requiring its encapsulation in a suitable (nanosized) delivery system. On the intracellular level, the endosomal membrane is a major barrier following endocytosis of siRNA-loaded nanoparticles in target cells and innovative materials to promote cytosolic siRNA delivery are highly sought after. We previously identifi

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Mazzaglia, Antonino, Norberto Micali, Luigi Monsù Scolaro, Maria Teresa Sciortino, Salvatore Sortino, and Valentina Villari. "Design of photosensitizer/cyclodextrin nanoassemblies: spectroscopy, intracellular delivery and photodamage." Journal of Porphyrins and Phthalocyanines 14, no. 08 (2010): 661–77. http://dx.doi.org/10.1142/s1088424610002562.

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The engineering of multifunctional nanoparticles carrying photosensitizer drugs (PS) and exposing binding groups for cellular receptors is of increasing interest in therapeutics and diagnostics applications. Natural and modified cyclodextrins (CDs) offer useful scaffolds to bind PS guests by supramolecular interactions. In particular, amphiphilic β-CDs, which form nanoaggregates of diverse shape and size according to the polarity of substituent groups on the rims, include in their different compartments as CD cavity, hydrophilic and hydrophobic portion, PS with different physicochemical proper

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Khalil, Ali, Saad Saba, Catherine Ribault, et al. "Synthesis of Poly(Dimethylmalic Acid) Homo- and Copolymers to Produce Biodegradable Nanoparticles for Drug Delivery: Cell Uptake and Biocompatibility Evaluation in Human Heparg Hepatoma Cells." Polymers 12, no. 8 (2020): 1705. http://dx.doi.org/10.3390/polym12081705.

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Hydrophobic and amphiphilic derivatives of the biocompatible and biodegradable poly(dimethylmalic acid) (PdiMeMLA), varying by the nature of the lateral chains and the length of each block, respectively, have been synthesized by anionic ring-opening polymerization (aROP) of the corresponding monomers using an initiator/base system, which allowed for very good control over the (co)polymers’ characteristics (molar masses, dispersity, nature of end-chains). Hydrophobic and core-shell nanoparticles (NPs) were then prepared by nanoprecipitation of hydrophobic homopolymers and amphiphilic block copo

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Straehla, Joelle, Cynthia Hajal, Hannah Safford, et al. "EXTH-26. LAYER-BY-LAYER NANOPARTICLES DESIGNED FOR DUAL BLOOD-BRAIN BARRIER AND GLIOMA TARGETING." Neuro-Oncology 23, Supplement_6 (2021): vi168—vi169. http://dx.doi.org/10.1093/neuonc/noab196.665.

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Abstract BACKGROUND While biologically diverse, high grade gliomas (HGGs) have a dismal prognosis in both adults and children. Promising therapeutics have been identified for HGGs based on common genomic alterations and aberrant signaling pathways, but achieving effective drug exposure at the tumor site remains a challenge largely due to the blood-brain barrier (BBB). HYPOTHESIS: A tunable nanocarrier platform can improve nanoparticle delivery across the (BBB) and into glioma cells. METHODS We synthesized layer-by-layer nanoparticles by coating anionic, fluorescent liposomes with nanometers-th

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17

García-Cambrón, José Bryan, José Luis Cerriteño-Sánchez, Rocío Lara-Romero, et al. "Development of Glycyrrhizinic Acid-Based Lipid Nanoparticle (LNP-GA) as An Adjuvant That Improves the Immune Response to Porcine Epidemic Diarrhea Virus Spike Recombinant Protein." Viruses 16, no. 3 (2024): 431. http://dx.doi.org/10.3390/v16030431.

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Porcine epidemic diarrhea virus (PEDV) has affected the pork industry worldwide and during outbreaks the mortality of piglets has reached 100%. Lipid nanocarriers are commonly used in the development of immunostimulatory particles due to their biocompatibility and slow-release delivery properties. In this study, we developed a lipid nanoparticle (LNP) complex based on glycyrrhizinic acid (GA) and tested its efficacy as an adjuvant in mice immunized with the recombinant N-terminal domain (NTD) of porcine epidemic diarrhea virus (PEDV) spike (S) protein (rNTD-S). The dispersion stability analysi

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18

Kim, Tae-Hyun, Gyeong Jin Lee, Joo-Hee Kang, Hyoung-Jun Kim, Tae-il Kim, and Jae-Min Oh. "Anticancer Drug-Incorporated Layered Double Hydroxide Nanohybrids and Their Enhanced Anticancer Therapeutic Efficacy in Combination Cancer Treatment." BioMed Research International 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/193401.

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Objective. Layered double hydroxide (LDH) nanoparticles have been studied as cellular delivery carriers for anionic anticancer agents. As MTX and 5-FU are clinically utilized anticancer drugs in combination therapy, we aimed to enhance the therapeutic performance with the help of LDH nanoparticles.Method. Anticancer drugs, MTX and 5-FU, and their combination, were incorporated into LDH by reconstruction method. Simply, LDHs were thermally pretreated at 400°C, and then reacted with drug solution to simultaneously form drug-incorporated LDH. Thus prepared MTX/LDH (ML), 5-FU/LDH (FL), and (MTX +

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Tseu, Gloria Yi Wei, and Khairul Azfar Kamaruzaman. "A Review of Different Types of Liposomes and Their Advancements as a Form of Gene Therapy Treatment for Breast Cancer." Molecules 28, no. 3 (2023): 1498. http://dx.doi.org/10.3390/molecules28031498.

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Breast cancer incidence and mortality rates have increased exponentially during the last decade, particularly among female patients. Current therapies, including surgery and chemotherapy, have significant negative physical and mental impacts on patients. As a safer alternative, gene therapy utilising a therapeutic gene with the potential to treat various ailments is being considered. Delivery of the gene generally utilises viral vectors. However, immunological reactions and even mortality have been recorded as side effects. As a result, non-viral vectors, such as liposomes, a system composed o

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Busmann, Eike Folker, and Henrike Lucas. "Particle Engineering of Innovative Nanoemulsion Designs to Modify the Accumulation in Female Sex Organs by Particle Size and Surface Charge." Pharmaceutics 14, no. 2 (2022): 301. http://dx.doi.org/10.3390/pharmaceutics14020301.

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Particle engineering of nanosized drug delivery systems (DDS) can be used as a strategic tool to influence their pharmacokinetics after intravenous (i.v.) application by the targeted adaptation of their particle properties according to the needs at their site of action. This study aimed to investigate particle properties depending on patterns in the biodistribution profile to modify the accumulation in the female sex organs using tailor-made nanoemulsion designs and thereby to either increase therapeutic efficiency for ovarian dysfunctions and diseases or to decrease the side effects caused by

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Das, Horváth, Šafranko, Jokić, Széchenyi, and Kőszegi. "Antimicrobial Activity of Chamomile Essential Oil: Effect of Different Formulations." Molecules 24, no. 23 (2019): 4321. http://dx.doi.org/10.3390/molecules24234321.

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Essential oils (EOs) are highly lipophilic, which makes the measurement of their biological action difficult in an aqueous environment. We formulated a Pickering nanoemulsion of chamomile EO (CPe). Surface-modified Stöber silica nanoparticles (20 nm) were prepared and used as a stabilizing agent of CPe. The antimicrobial activity of CPe was compared with that of emulsion stabilized with Tween 80 (CT80) and ethanolic solution (CEt). The antimicrobial effects were assessed by their minimum inhibitory concentration (MIC90) and minimum effective (MEC10) concentrations. Besides growth inhibition (C

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Das, Sourav, Barbara Vörös-Horváth, Tímea Bencsik, et al. "Antimicrobial Activity of Different Artemisia Essential Oil Formulations." Molecules 25, no. 10 (2020): 2390. http://dx.doi.org/10.3390/molecules25102390.

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The extreme lipophilicity of essential oils (EOs) impedes the measurement of their biological actions in an aqueous environment. We formulated oil in water type Pickering Artemisia annua EO nanoemulsions (AEP) with surface-modified Stöber silica nanoparticles (20 nm) as the stabilizing agent. The antimicrobial activity of AEP and its effects on mature Candida biofilms were compared with those of Tween 80 stabilized emulsion (AET) and ethanolic solution (AEE) of the Artemisia EO. The antimicrobial activity was evaluated by using the minimum inhibitory concentrations (MIC90) and minimum effectiv

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Uchida, Noriyuki, Masayoshi Yanagi, and Hiroki Hamada. "Transdermal Delivery of Anionic Phospholipid Nanoparticles Containing Fullerene." Natural Product Communications 17, no. 2 (2022): 1934578X2210784. http://dx.doi.org/10.1177/1934578x221078444.

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In this work, we prepared a transparent dispersion of fullerene nanoparticles by sonication with anionic phospholipids of 1,2-dipalmitoyl-sn-glycero-3-phosphorylglycerol (DPPG) with fluorescently NBD-labeled 1,2-dipalmitoyl-sn-glycero-3-phosphorylethanolamine (DPPE). Upon incubation of the fullerene nanoparticles with a rat skin, the nanoparticles successfully penetrated the stratum corneum and reached the epidermis.

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Yuan, Hong, Wei Zhang, Yong-Zhong Du, and Fu-Qiang Hu. "Ternary nanoparticles of anionic lipid nanoparticles/protamine/DNA for gene delivery." International Journal of Pharmaceutics 392, no. 1-2 (2010): 224–31. http://dx.doi.org/10.1016/j.ijpharm.2010.03.025.

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Parlea, Lorena, Anu Puri, Wojciech Kasprzak, et al. "Cellular Delivery of RNA Nanoparticles." ACS Combinatorial Science 18, no. 9 (2016): 527–47. http://dx.doi.org/10.1021/acscombsci.6b00073.

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Faraji, Amir H., and Peter Wipf. "Nanoparticles in cellular drug delivery." Bioorganic & Medicinal Chemistry 17, no. 8 (2009): 2950–62. http://dx.doi.org/10.1016/j.bmc.2009.02.043.

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Hamada, Hiroki, Daisuke Uesugi, Kohji Ishihara, et al. "Transdermal Delivery of Paclitaxel-Anionic Nanoparticles to Epidermis Layer, Pterostilbene, and Pterostilbene glycoside, and Their Application for Treatment of Skin Cancer and Wrinkle." International Journal of Current Microbiology and Applied Sciences 13, no. 4 (2024): 1–7. http://dx.doi.org/10.20546/ijcmas.2024.1304.001.

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Composite nanoparticles, “anionic bicelles”, composed of anionic phospholipid of 1,2- dipalmitoyl- sn-glycero-3-phosphorylglycerol (DPPG) and paclitaxel were prepared by mixing them in water and a subsequent heating/cooling/ultrasonicating process. Anionic DPPG-paclitaxel nanoparticles (particle size: 12 nm) could be prepared after ultrasonic fragmentation at low temperature of 4°C. Upon addition of fluorescently labeled paclitaxel nanoparticles stabilized with DPPG to rat skin tissue (in vitro), the nanoparticles “anionic bicelles” (particle size: 12 nm) infiltrated into the epidermis layer p

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Uchida, Noriyuki, Masayoshi Yanagi, and Hiroki Hamada. "Piceid Nanoparticles Stabilized by Anionic Phospholipids for Transdermal Delivery." Natural Product Communications 15, no. 5 (2020): 1934578X2092557. http://dx.doi.org/10.1177/1934578x20925578.

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Piceid, stilbenoid glucoside, is a representative resveratrol derivative. Because of a high tyrosinase inhibitory activity of piceid through resveratrol derivatives, transdermal delivery of piceid has been desired for taking advantage of the activity. Here we successfully prepared composite nanoparticles composed of anionic phospholipid of 1,2-dipalmitoyl- sn-glycero-3-phosphorylglycerol (DPPG) and piceid by mixing them in water and a subsequent heating/cooling process. When small-sized fluorescently labeled DPPG-piceid (DPPG-FLpiceid) nanoparticles were added to rat skin tissue, FLpiceid mole

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Chavanpatil, Mahesh D., Ayman Khdair, and Jayanth Panyam. "Nanoparticles for Cellular Drug Delivery: Mechanisms and Factors Influencing Delivery." Journal of Nanoscience and Nanotechnology 6, no. 9 (2006): 2651–63. http://dx.doi.org/10.1166/jnn.2006.443.

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Polymeric nanoparticles have demonstrated enormous potential as cellular drug delivery vehicles. Nanoparticles improve drug's stability as well as its availability and retention at the target intracellular site of action. Therapeutic efficacy of nanoparticles can be further enhanced by conjugating specific ligands to nanoparticle surface. Ligand conjugation can also be used to favorably modify the intracellular disposition of nanoparticles. A number of ligands are available for this purpose; use of a specific ligand depends on the target cell, the material used for nanoparticle formulation, an

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Huang, Xiaomeng, Sebastian Schwind, Ann-Kathrin Eisfeld, et al. "Therapeutic Targeting of the RAS-Pathway by Synthetic Mir-181a Nanoparticles in Acute Myeloid Leukemia (AML)." Blood 120, no. 21 (2012): 2422. http://dx.doi.org/10.1182/blood.v120.21.2422.2422.

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Abstract Abstract 2422 Today most AML patients (pts) still fail to achieve long-term survival. New therapeutic options are needed. We and others reported that high miR-181a expression associated with better outcomes in AML pts (Marcucci et al NEJM 2008; Schwind et al JCO 2010; Li et al Blood 2012), but the underlying mechanisms remain unclear. Aberrant RAS activation by mutations or overexpression is frequent in human malignancies, including AML. Previously KRAS was described as a direct miR-181a target in oral squamous cell carcinoma (Shin et al BBRC 2011). Here we confirmed KRAS as a direct

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Pamujula, Sarala, Sidhartha Hazari, Gevoni Bolden, et al. "Cellular delivery of PEGylated PLGA nanoparticles." Journal of Pharmacy and Pharmacology 64, no. 1 (2011): 61–67. http://dx.doi.org/10.1111/j.2042-7158.2011.01376.x.

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Uchida, Noriyuki, Masayoshi Yanagi, Kei shimoda, and Hiroki Hamada. "Transdermal Delivery of Small-Sized Resveratrol Nanoparticles to Epidermis Using Anionic Phospholipids." Natural Product Communications 15, no. 9 (2020): 1934578X2095144. http://dx.doi.org/10.1177/1934578x20951443.

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Composite nanoparticles composed of anionic phospholipid of 1,2-dipalmitoyl- sn-glycero-3-phosphorylglycerol (DPPG) and resveratrol (Res) were successfully prepared by mixing them in water and a subsequent heating/cooling process. Small-sized DPPG-Res nanoparticles (<60 nm) could be prepared by ultrasonic fragmentation. Upon addition of size-controlled fluorescently labeled Res (FLRes) nanoparticles stabilized with DPPG (DPPG-FLRes) to rat skin tissue, FLRes molecules infiltrated into the epidermis layer permeating stratum corneum.

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Insua, Ignacio, Evangelos Liamas, Zhenyu Zhang, Anna F. A. Peacock, Anne Marie Krachler, and Francisco Fernandez-Trillo. "Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers." Polymer Chemistry 7, no. 15 (2016): 2684–90. http://dx.doi.org/10.1039/c6py00146g.

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Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targetingPseudomonas aeruginosa's elastase.

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Wendorf, Janet, James Chesko, Jina Kazzaz, et al. "A comparison of anionic nanoparticles and microparticles as vaccine delivery systems." Human Vaccines 4, no. 1 (2008): 44–49. http://dx.doi.org/10.4161/hv.4.1.4886.

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Mocanu, G., M. Nichifor, L. Picton, E. About-Jaudet, and D. Le Cerf. "Preparation and characterization of anionic pullulan thermoassociative nanoparticles for drug delivery." Carbohydrate Polymers 111 (October 2014): 892–900. http://dx.doi.org/10.1016/j.carbpol.2014.05.037.

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Hussain, Majad, Mikhail Shchepinov, Muhammad Sohail, et al. "A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides." Journal of Controlled Release 99, no. 1 (2004): 139–55. http://dx.doi.org/10.1016/j.jconrel.2004.06.009.

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Liu, Yang, Ziyuan Song, Nan Zheng, Kenya Nagasaka, Lichen Yin та Jianjun Cheng. "Systemic siRNA delivery to tumors by cell-penetrating α-helical polypeptide-based metastable nanoparticles". Nanoscale 10, № 32 (2018): 15339–49. http://dx.doi.org/10.1039/c8nr03976c.

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Metastable nanoparticles capable of tumor targeting, tumor penetration, and selective tumor cell internalization were developed based on membrane penetrating, helical polypeptide PVBLG-8 and anionic PLG, for the efficient encapsulation and delivery of EGFR siRNA.

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Uchida, Noriyuki, Masayoshi Yanagi, and Hiroki Hamada. "Size-Tunable Paclitaxel Nanoparticles Stabilized by Anionic Phospholipids for Transdermal Delivery Applications." Natural Product Communications 15, no. 3 (2020): 1934578X1990068. http://dx.doi.org/10.1177/1934578x19900684.

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Composite nanoparticles composed of an anionic phospholipid of 1,2-dipalmitoyl-sn-glycero-3-phosphorylglycerol (DPPG) and paclitaxel (PTX) were successfully prepared by mixing them in water followed by a subsequent heating/cooling process. The size of DPPG-PTX nanoparticle could be easily tuned by ultrasonic fragmentation. Upon addition of small-sized fluorescently labeled paclitaxel (FLPTX) nanoparticles with DPPG (DPPG-FLPTX) to rat skin tissue, part of the FLPTX molecules permeated to the stratum corneum.

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Știufiuc, Gabriela Fabiola, Ștefan Nițică, Valentin Toma, et al. "Synergistical Use of Electrostatic and Hydrophobic Interactions for the Synthesis of a New Class of Multifunctional Nanohybrids: Plasmonic Magneto-Liposomes." Nanomaterials 9, no. 11 (2019): 1623. http://dx.doi.org/10.3390/nano9111623.

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By carefully controlling the electrostatic interactions between cationic liposomes, which already incorporate magnetic nanoparticles in the bilayers, and anionic gold nanoparticles, a new class of versatile multifunctional nanohybrids (plasmonic magneto-liposomes) that could have a major impact in drug delivery and controlled release applications has been synthesized. The experimental results confirmed the successful synthesis of hydrophobic superparamagnetic iron oxide nanoparticles (SPIONs) and polyethylene glycol functionalized (PEGylated) gold nanoparticles (AuNPs). The SPIONs were incorpo

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Kang, Li, Qiao Li, Yonghui Jing, et al. "Auricularia auricula Anionic Polysaccharide Nanoparticles for Gastrointestinal Delivery of Pinus koraiensis Polyphenol Used in Bone Protection under Weightlessness." Molecules 29, no. 1 (2024): 245. http://dx.doi.org/10.3390/molecules29010245.

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Auricularia auricula polysaccharides used in Pinus koraiensis polyphenol encapsulation and delivery under weightlessness are rarely reported. In this study, an anionic polysaccharide fragment named AAP Iα with a molecular weight of 133.304 kDa was isolated and purified to construct a polyphenol encapsulation system. Nanoparticles named NPs-PP loaded with a rough surface for Pinus koraiensis polyphenol (PP) delivery were fabricated by AAP Iα and ε-poly-L-lysine (ε-PL). SEM and the DLS tracking method were used to observe continuous changes in AAP Iα, ε-PL and PP on the nanoparticles’ rough surf

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Soto, Ernesto R., Abaigeal C. Caras, Lindsey C. Kut, Melissa K. Castle, and Gary R. Ostroff. "Glucan Particles for Macrophage Targeted Delivery of Nanoparticles." Journal of Drug Delivery 2012 (October 13, 2012): 1–13. http://dx.doi.org/10.1155/2012/143524.

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Glucan particles (GPs) are hollow, porous 2–4 μm microspheres derived from the cell walls of Baker's yeast (Saccharomyces cerevisiae). The 1,3-β-glucan outer shell provides for receptor-mediated uptake by phagocytic cells expressing β-glucan receptors. GPs have been used for macrophage-targeted delivery of soluble payloads (DNA, siRNA, protein, and small molecules) encapsulated inside the hollow GPs via core polyplex and layer-by-layer (LbL) synthetic strategies. In this communication, we report the incorporation of nanoparticles as cores inside GPs (GP-NP) or electrostatically bound to the su

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Feng, Song, Sisi Cui, Jing Jin, and Yueqing Gu. "Macrophage as cellular vehicles for delivery of nanoparticles." Journal of Innovative Optical Health Sciences 07, no. 03 (2014): 1450023. http://dx.doi.org/10.1142/s1793545814500230.

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Treatment of malignant brain tumors continues to challenge scientists and clinicians alike. Location of these tumors within the central nervous system (CNS), which is considered a "privileged" organ, can prevent the penetration of chemotherapeutic agents through the blood–brain barrier (BBB). To overcome this limitation, nanoparticles are taken up and transported by macrophage and then delivered directly into the CNS. In this study, we used macrophage to uptake the folate-targeted bifunctional micelles loaded with near-infrared (NIR) dye ICG-Der-01 and investigate the dynamic bio-distributions

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Xu, Zhi Ping, Qing Hua Zeng, Gao Qing Lu, and Ai Bing Yu. "Inorganic nanoparticles as carriers for efficient cellular delivery." Chemical Engineering Science 61, no. 3 (2006): 1027–40. http://dx.doi.org/10.1016/j.ces.2005.06.019.

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Lamson, Nicholas G., Adrian Berger, Katherine C. Fein, and Kathryn A. Whitehead. "Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability." Nature Biomedical Engineering 4, no. 1 (2019): 84–96. http://dx.doi.org/10.1038/s41551-019-0465-5.

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Heidel, Jeremy D., and Thomas Schluep. "Cyclodextrin-Containing Polymers: Versatile Platforms of Drug Delivery Materials." Journal of Drug Delivery 2012 (February 1, 2012): 1–17. http://dx.doi.org/10.1155/2012/262731.

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Nanoparticles are being widely explored as potential therapeutics for numerous applications in medicine and have been shown to significantly improve the circulation, biodistribution, efficacy, and safety profiles of multiple classes of drugs. One leading class of nanoparticles involves the use of linear, cyclodextrin-containing polymers (CDPs). As is discussed in this paper, CDPs can incorporate therapeutic payloads into nanoparticles via covalent attachment of prodrug/drug molecules to the polymer (the basis of the Cyclosert platform) or by noncovalent inclusion of cationic CDPs to anionic, n

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Mitrach, Franziska, Maximilian Schmid, Magali Toussaint, et al. "Amphiphilic Anionic Oligomer-Stabilized Calcium Phosphate Nanoparticles with Prospects in siRNA Delivery via Convection-Enhanced Delivery." Pharmaceutics 14, no. 2 (2022): 326. http://dx.doi.org/10.3390/pharmaceutics14020326.

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Convection-enhanced delivery (CED) has been introduced as a concept in cancer treatment to generate high local concentrations of anticancer therapeutics and overcome the limited diffusional distribution, e.g., in the brain. RNA interference provides interesting therapeutic options to fight cancer cells but requires nanoparticulate (NP) carriers with a size below 100 nm as well as a low zeta potential for CED application. In this study, we investigated calcium phosphate NPs (CaP-NPs) as siRNA carriers for CED application. Since CaP-NPs tend to aggregate, we introduced a new terpolymer (o14PEGMA

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Wang, Ming, John A. Zuris, Fantao Meng, et al. "Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles." Proceedings of the National Academy of Sciences 113, no. 11 (2016): 2868–73. http://dx.doi.org/10.1073/pnas.1520244113.

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A central challenge to the development of protein-based therapeutics is the inefficiency of delivery of protein cargo across the mammalian cell membrane, including escape from endosomes. Here we report that combining bioreducible lipid nanoparticles with negatively supercharged Cre recombinase or anionic Cas9:single-guide (sg)RNA complexes drives the electrostatic assembly of nanoparticles that mediate potent protein delivery and genome editing. These bioreducible lipids efficiently deliver protein cargo into cells, facilitate the escape of protein from endosomes in response to the reductive i

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Nguyen, Thi-Thao-Linh, and Van-An Duong. "Solid Lipid Nanoparticles." Encyclopedia 2, no. 2 (2022): 952–73. http://dx.doi.org/10.3390/encyclopedia2020063.

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Solid lipid nanoparticles (SLNs) are produced from physiologically biocompatible lipids. They have been proven to improve solubility, cellular uptake, and stability, reduce enzyme degradation, and prolong the circulation time of various drugs. SLNs have been applied in the oral, parenteral, transdermal, intranasal, ocular, and pulmonary drug delivery of different drugs, with enhanced safety, bioavailability, and overall therapeutic effects. In this entry, the authors summarize the primary features of SLNs, methods to prepare SLNs, and recent applications of SLNs in drug delivery. Owing to thei

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LEE, SEUNG-CHUL, SANG-WHA LEE, and IK-JOONG KANG. "PREPARATION AND CHARACTERIZATION OF CHITOSAN–GOLD NANOCOMPOSITES FOR DRUG DELIVERY APPLICATION." Surface Review and Letters 17, no. 02 (2010): 165–72. http://dx.doi.org/10.1142/s0218625x10013643.

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Chitosan–gold nanocomposites were fabricated via a seed-mediated goldshell growth over chitosan–gold nanocomplex and examined as a potential biomedical agent for drug delivery. Chitosan–gold nanocomplex was formed by the electrostatic interaction between of cationic chitosan nanoparticles (ca. 50 nm) and anionic gold colloids (ca. 1–3 nm) and the subsequent reduction of gold salts was conducted to form the gold clusters over the chitosan nanoparticles in the presence of reducing ascorbic acid. The resultant nanocomposites (or nanoshells) exhibited the absorption peak around 580 nm that was cle

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Mao, Wei, Sol Lee, Ji Un Shin, and Hyuk Sang Yoo. "Surface-Initiated Atom Transfer Polymerized Anionic Corona on Gold Nanoparticles for Anti-Cancer Therapy." Pharmaceutics 12, no. 3 (2020): 261. http://dx.doi.org/10.3390/pharmaceutics12030261.

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Surface initiated atom transfer radical polymerization (SI-ATRP) documented a simple but efficient technique to grow a dense polymer layer on any surface. Gold nanoparticles (AuNPs) give a broad surface to immobilize sulfhyryl group-containing initiators for SI-ATRP; in addition, AuNPs are the major nanoparticulate carriers for delivery of anti-cancer therapeutics, since they are biocompatible and bioinert. In this work, AuNPs with a disulfide initiator were polymerized with sulfoethyl methacrylate by SI-ATRP to decorate the particles with anionic corona, and branched polyethyeleneimine (PEI)

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