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Dissertations / Theses on the topic 'Children with diseases of the CNS'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Meister, Sabrina [Verfasser]. "Blood-CNS barriers in neurodegenerative diseases / Sabrina Meister." Mainz : Universitätsbibliothek Mainz, 2015. http://d-nb.info/107232167X/34.

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2

Makhdoum, Hatim. "Human cytomegalovirus glycoprotein genotypes and their role in neurological diseases." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/human-cytomegalovirus-glycoprotein-genotypes-and-their-role-in-neurological-diseases(c3817100-f42f-46ec-a371-4f107a854016).html.

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Human cytomegalovirus (HCMV) is a ubiquitous pathogen with ability to establish a persistent infection in the host for many years. Diseases are more serious in congenitally infected infants and immunocompromised individuals such as AIDS patients and transplant recipients. It rarely causes disease among immunocompetent individuals. The envelope glycoproteins of HCMV (gB, gH, gN, gM, gL and gO) are essential for viral infectivity as they are involved in attachment and penetration of the host cell, cell to cell viral transmission and fusion of infected cells. Also, they are known to be important

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3

Alterman, Julia F. "A CNS-Active siRNA Chemical Scaffold for the Treatment of Neurodegenerative Diseases." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1027.

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Small interfering RNAs (siRNAs) are a promising class of drugs for treating genetically-defined diseases. Therapeutic siRNAs enable specific modulation of gene expression, but require chemical architecture that facilitates efficient in vivodelivery. siRNAs are informational drugs, therefore specificity for a target gene is defined by nucleotide sequence. Thus, developing a chemical scaffold that efficiently delivers siRNA to a particular tissue provides an opportunity to target any disease-associated gene in that tissue. The goal of this project was to develop a chemical scaffold that supports

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4

Бабич, Володимир Андрійович, Владимир Андреевич Бабич, Volodymyr Andriiovych Babych, and E. B. Obaigwa. "Inflammatory diseases in children. Osteomyelitis in children." Thesis, Видавництво СумДУ, 2011. http://essuir.sumdu.edu.ua/handle/123456789/15989.

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Definition: osteomyelitis is an infection of the bone that can occur after a spread of an infection from the blood stream (hematogenous osteomyelitis), after spread of another infection (such as arthritis). When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/15989

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5

Beutner, Clara [Verfasser]. "Embryonic Stem Cell Derived Microglia and its application in CNS diseases / Clara Beutner." Bonn : Universitäts- und Landesbibliothek Bonn, 2012. http://d-nb.info/1044971622/34.

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6

AMBROSINI, Dario. "Design and Synthesis of New Potential Therapeutic Tools for the Treatment of CNS Diseases." Doctoral thesis, Università degli Studi di Camerino, 2012. http://hdl.handle.net/11581/401808.

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Most of dopaminergic agonist structures bear the 2-(3-hydroxyphenyl)ethylamine (1) pharmocophoric moiety or its bioisosteres (chapter 2). However, D2-like receptor ligands endowed with good affinity, although lacking of such a scaffold are known. In the past years, this research group developed new potential D2-like ligands based on the template structure of phenoxyethylamine (2, 3, 4, 5; chapter 2), which is known to be a good lead to build up dopaminergic ligands. Many SAR studies have reported phenolic and non-phenolic structures endowed with high dopaminergic affinity, based on the N-benzy

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7

Choudhury, Sourav Roy. "Developing an Adeno-Associated Viral Vector (AAV) Toolbox for CNS Gene Therapy: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/809.

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Neurological disorders – disorders of the brain, spine and associated nerves – are a leading contributor to global disease burden with a sizable economic cost. Adeno-associated viral (AAV) vectors have emerged as an effective platform for CNS gene therapy and have shown early promise in clinical trials. These trials involve direct infusion into brain parenchyma, an approach that may be suboptimal for treatment of neurodegenerative disorders, which often involve more than a single structure in the CNS. However, overall neuronal transduction efficiency of vectors derived from naturally occurring

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8

Choudhury, Sourav Roy. "Developing an Adeno-Associated Viral Vector (AAV) Toolbox for CNS Gene Therapy: A Dissertation." eScholarship@UMMS, 2001. http://escholarship.umassmed.edu/gsbs_diss/809.

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Neurological disorders – disorders of the brain, spine and associated nerves – are a leading contributor to global disease burden with a sizable economic cost. Adeno-associated viral (AAV) vectors have emerged as an effective platform for CNS gene therapy and have shown early promise in clinical trials. These trials involve direct infusion into brain parenchyma, an approach that may be suboptimal for treatment of neurodegenerative disorders, which often involve more than a single structure in the CNS. However, overall neuronal transduction efficiency of vectors derived from naturally occurring

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9

Rinaldo, Carina, and Karin Johansson. "Postoperativ smärtbehandling till barn med hjärntumör." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126841.

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Smärta i samband med intrakraniell kirurgi liknar smärta i samband med all annan form av kirurgi. Syftet var att granska hur barn med hjärntumör smärtbedömts och smärtbehandlats postoperativt efter tumörkirurgi. Metod: Totalt har journaler för 40 barn (20 barn på Akademiska barnsjukhuset i Uppsala och 20 barn på Astrid Lindgrens barnsjukhus vid Karolinska sjukhuset, Stockholm) som opererats för tumörer i hjärnan granskats, avseende smärtbedömning, användandet av smärtskalor, farmakologiska och ickefarmakologisk smärtbehandling de tre första postoperativa dygnen. Resultat: Studien visade att sm

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10

Awan, Fazli Rabbi. "Evaluation of magnetic resonance methods to study the CNS pathology in mouse models of glycolipid storage diseases." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424856.

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11

Vitkovskyi, O. O. "Acute odontogenic diseases in children, causes of development." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17838.

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12

PATRIZI, SARA. "Multi-omics approaches to complex diseases in children." Doctoral thesis, Università degli Studi di Trieste, 2022. http://hdl.handle.net/11368/3015193.

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Le tecnologie “-omiche” studiano l’insieme delle molecole presenti nel campione biologico di interesse, in maniera completamente agnostica. L’integrazione di diversi tipi di dati omici, chiamata “multi-omica” o “omica verticale”, fornisce indicazioni importanti su come le cause di una malattia portano alle sue conseguenze funzionali. Queste indicazioni sono particolarmente utili nel caso delle malattie complesse, che sono causate dall’interazione di vari fattori genetici e regolatori con vari contributi ambientali. In questo lavoro, degli approcci multi-omici appropriati sono stati applicati a

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13

Zaccariotto, Eva. "The blood-brain barrier and San Filippo Syndrome: a model for pathophisiology studies of CNS in lysosomal storage diseases." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426008.

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The lysosomal storage diseases (LSDs) are a large and heterogeneous group of disorders resulting from defects in various aspects of lysosomal function. They commonly afflict infants and young children and mostly involve pathology of the brain which is currently untreatable when it’s present. All animals with a well developed central nervous system (CNS) have a blood-brain barrier (BBB) that largely isolates the brain from alterations in the composition of the blood stream and the continuous changes that take place in these general body fluids. This BBB also impedes the global CNS delivery of m

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14

Biduchak, A. S. "The problem of cardiovascular diseases among children and adolescents." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18858.

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15

Charles, Karen. "Parental Perspectives on Vaccinating Children Against Preventable Childhood Diseases." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3553.

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Childhood immunization has been one of the most important public health measures in the 20th century. In the United States, 95% of avoidable childhood diseases have been prevented through vaccinations. However, there have been growing concerns around the safety of vaccines, and this increased uncertainty has led to decreases in vaccination participation and increases in cases of preventable diseases. As such, is it important to understand why parents are not vaccinating their children. A qualitative approach was utilized to conduct this study. Flyers to recruit participants were distributed by

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16

曾綺霞 and Yee-ha Lucia Tsang. "Neurocognitive sequelae of children born prematurely." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41712596.

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17

Jee, Larry Donald. "The urological management of children with spinal dysraphism." Master's thesis, University of Cape Town, 1990. http://hdl.handle.net/11427/25677.

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This project was undertaken with the following aims: 1) To generate a data base concerning the management of children with congenital spinal anomalies, who are known to form a significant proportion of the patients being treated in the Department of Paediatric Urology at Red Cross Hospital. 2) To assess the results of the management of these children, with special attention to the goals of therapy, namely preservation of renal function, establishment of urinary continence and protection from urinary tract infection. 3) To compare the treatment methods and results obtained to those repo

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18

Bonaccorso, Angela. "Nanocarriers for nose-to-brain delivery: a novel strategy for the treatment of CNS disorders." Doctoral thesis, Università di Catania, 2018. http://hdl.handle.net/10761/3622.

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The number of neurodegenerative diseases is estimated to be a few hundred. Despite the high prevalence and incidence, central nervous system (CNS) disorders are still incurable. The blood-brain-barrier (BBB) precludes the delivery of drugs to the brain, preventing the therapy of a number of neurological disorders. In the last 20 years, intranasal (IN) administration has gained great attention in research and has been investigated with regard to its feasibility to serve as a direct drug transport route to the CNS. Drugs can be transported directly from the nasal cavity to the brain through the

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19

Nyberg, Colleen H. "Social contact and childhood morbidity in a rural Caribbean village : testing an epidemiological hypothesis /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1422945.

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20

Dame, Joycelyn Assimeng. "Pseudomonas aeruginosa bloomstream infection at a tertiary referral hospital for children." Master's thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/32633.

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Introduction This study describes the disease burden, clinical characteristics, antibiotic management, impact of multidrug resistance and outcome of Pseudomonas aeruginosa bloodstream infection (PABSI) among children admitted to a tertiary referral hospital for children in Cape Town, South Africa. Methods A retrospective descriptive study was conducted at a paediatric referral hospital in Cape Town, South Africa. Demographic and clinical details, antibiotic management and patient outcome information were extracted from medical and laboratory records. Antibiotic susceptibility results of identi

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21

Hurtig, Wennlöf Anita. "Cardiovascular risk factors in children /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-179-2/.

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22

Hui, Ling, and 許凌. "Dobutamine stress echocardiography for children with acquired and congenital cardiac diseases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29914954.

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23

Saleh, Zeinab Saleh. "Diarrhoeal diseases in pre-school children in the United Arab Emirates." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341896.

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24

Alkahtani, Zuhair Motlak. "Screening for, and awareness about, periodontal diseases in children and adolescents." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/16854/.

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Aims: The first study aimed to investigate the extent to which paediatric dental specialists and General Dental Practitioners use the Basic Periodontal Examination (BPE) screening system on their patients, and the extent to which they are aware of the guidelines for periodontal screening and management of children and adolescents. The second study aimed to investigate parents’ awareness about periodontal disease, and the importance of periodontal screening in children. Methods: Two questionnaires were developed. The first was mailed to all paediatric dental specialists registered with the Brit

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25

Popeliuk, N. O. "Features of diagnosis and treatment of atypical respiratory diseases in children." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19807.

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26

Martin, Helena. "Vascular functions in infants, children and their mothers /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4656-6/.

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27

Danilov, Alexandre I. "Neurogenesis, neural stem cells and nitric oxide in neuroinflammation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-484-8/.

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28

Pruefe, Jenny Maria. "Seeking certainty in an uncertain world : psychosocial aspects of renal replacement therapies in children and adolescents." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607822.

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29

Crockett, Alan J. "The prevalence of respiratory symptoms in urban and rural South Australian school children /." Title page, table of contents and abstract only, 1988. http://web4.library.adelaide.edu.au/theses/09MPM/09mpmc943.pdf.

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30

Haysom, Leigh. "Antecedents of renal disease in aboriginal children (ARDAC study)." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/7298.

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31

Svedberg, Lena. "Cold feet in children with neurological disorders /." Gothenburg : Institute of Neuroscience and Physiology, Clinical Neuroscience and Rehabilitation, Sahlgrenska Academy, University of Gothenburg, 2009. http://hdl.handle.net/2077/21042.

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32

Martinez, Teran Mercedes Leticia 1960. "MATERNAL BELIEFS AND FEEDING PRACTICES CONCERNING CHILDHOOD DIARRHEA AMONG MEXICANS." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276571.

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33

Tischer, Christina. "Domestic mould and microbial agents in relation to allergic diseases in children." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-143609.

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34

Cook, Arlene Jane. "The role of leukotrienes in diseases causing chronic airway obstruction in children." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244248.

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35

Hale, Elizabeth Dorothy Pamela. "Children of parent's with chronic inflammatory musculoskeletal diseases : experiences, needs and resources." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/40394.

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Overview: Whilst each section of the thesis is required to stand alone, it is presented in the following order so that the thesis has a logical flow. Literature review: Presents an overview of the rheumatic diseases and their impact upon parenting and families. We note the provision of patient education for parents, but not for their children. The comprehensive but selective narrative review focuses upon how adults and children conceptualise and understand illness, and explores the concept of normalisation as a potential family management strategy. Service Evaluation: We sought to establish wh

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36

Ноncharenko, V. A. "Structure of periodontic tissue diseases in children with insulin dependence diabetes mellitus." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19123.

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37

Thompson, Matthew James. "Predicting serious bacterial infections in children in primary care." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670104.

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38

Beard, Lorraine Joyce. "IgG subclass concentrations in children in health and disease /." Title page, contents and summary only, 1990. http://web4.library.adelaide.edu.au/theses/09MD/09mdb368.pdf.

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39

Jacobson, Lena. "Visual dysfunction and ocular signs associated with periventricular leukomalacia in children born preterm /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3325-1/.

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40

Fagerberg, Ulrika Lorentzon. "Fecal calprotectin in children with special reference to inflammatory bowel disease /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-013-8/.

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41

Tong, Pak-chiu, and 湯伯朝. "Translation and validation of the Hong Kong Chinese version of the pediatric quality of life inventoryTM (PedsQLTM) end-stage renaldisease module." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48425746.

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Objective The goal of this study is to report on the linguistic validation and reliability of the Hong Kong Chinese version of the Pediatric Quality of Life Inventory™ (PedsQL™) End-stage Renal Disease Module for Children with end-stage renal disease (ESRD) in Hong Kong, and its use to assess health-related quality of life (HRQOL) in end-stage renal disease children receiving different treatment modalities: peritoneal dialysis, haemodialysis and renal transplantation. Methods In part 1, forward and backward translations following a stringent validation protocol produced the Chinese trans

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42

Harper, Jeanine M. "A comparison of preadmission preparation programmes for children undergoing Day Care Surgery." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/31107.

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This study was an outcome oriented experiment considering the effects of Preadmission Preparation on 110 children between the ages of 5 and 12 years entering B.C.'s Children's Hospital for Day Care Surgery. Preadmission Preparation has been shown to reduce negative reactions to hospitalization on children having inpatient surgery. To date, no one has found Preadmission Preparation to be of benefit to children having Day Care Surgery. The study considered effects of attention only; general Preparation; Hospital Tours; Instructional Approaches (Modeling and Rehearsal-Instruction); and Modes of P

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43

Cheung, Yiu-fai, and 張耀輝. "An analysis of the determinants of peripheral conduit arterial stiffness in children and teenagers in health and disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B29761815.

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44

Rao, Arati. "Therapeutic strategies for restoring linear growth in children with Crohn's disease." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9005.

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Linear growth retardation affects up to 40% of children with Crohn’s disease (CD). It is caused by a combination of under\nutrition, and by a direct effect of cytokines on the axis linking human growth hormone (GH), insulin like growth factor\1 (IGF\1) and the growth plate of growing bones. In particular,the inflammation causes a functional insensitivity to GH, resulting in low circulating IGF\1. Current management is synonymous with the optimal management of childhood CD:to eliminate inflammation,and maintain remission. However, there is currently no consensus as to how to treat growth failur

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45

Thompson, Jacquelyn J. "How chronic illness affects family relationships and the individual." Online version, 2009. http://www.uwstout.edu/lib/thesis/2009/2009thompsonj.pdf.

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46

Ahmed, Sonia. "Predictors of childhood rickets in Bangladesh." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708047.

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47

Tomičić, Sara. "Environmental and immunological factors associated with allergic disease in children." Doctoral thesis, Linköpings universitet, Pediatrik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11615.

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Background: Allergic diseases are characterised by dysregulated immune responses. The first manifestation of the atopic phenotype is often food allergy, with symptoms like eczema. Food allergy in children is generally outgrown before 3 years of age, but a temporary food elimination diet is often advocated. The prevalence of allergic diseases has increased in affluent countries during the last decades, possibly as a consequence of a changed lifestyle leading to decreased microbial load. Aim: To investigate humoral, mucosal and cell-mediated immunity in association to allergy and allergy develop

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48

Fritts, Sharon Louise. "The impact of chronic illness on the family, the educators, and the community : an ethnographic research study /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.

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Thesis (Ph. D.)--Joint Doctoral Program in Educational Leadership (California State University, Fresno and University of California, Davis).<br>Typescript. Includes bibliographical references. Also available via the World Wide Web. (Restricted to UC campuses)

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49

Herman, Kazibwe. "Barriers experienced by parents/caregivers of children with clubfoot deformity attending specific clinics in Uganda." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_9901_1194348551.

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<p>Clubfoot is the most common congenital structural deformity that leads to physical impairments in children in many poor developing countries. Inadequately treated or neglected clubfoot has been found to be a common cause of ohysical disability globally among children and young growing adults. Many children are referred to the clinics for treatment but some parents do not comply with the treatment regimen whcih requires attending for consecutive treatment sessions. The purpose of this study was to investigate barriers to treatment attendance parents/caregivers of children with clubfoot encou

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50

Al-Khazraji, Atika Abdulaziz. "An investigation of common skin diseases experienced by children in the United Arab Emirates." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=136914.

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The objectives of this study were threefold: to determine the prevalence of skin diseases among primary school children in the UAE; to assess the ability of the primary health care physicians (PCPs) to diagnose skin diseases; and to plan a dermatological education program for children of the UAE. An epidemiological survey included the clinical examination of selected school children by two quantified dermatologists and the relationships between the prevalence of skin diseases and a range of hygiene and socioeconomic factors were examined.1536 Local schoolchildren aged 6-9 years were included.

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