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Journal articles on the topic 'Children with diseases of the CNS'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Zaitseva, M. V., V. V. Brzheskiy та T. N. Vorontsova. "Особенности микрофлоры конъюнктивальной полости у детей с воспалительными заболеваниями вспомогательных органов глаза". Russian ophthalmology of children, № 3 (10 жовтня 2023): 7–14. http://dx.doi.org/10.25276/2307-6658-2023-3-7-14.

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Purpose. To evaluate microflora of the conjunctival cavity of children in different age periods without and with inflammatory diseases of the eye adnexa. Material and methods. 370 children (398 eyes) aged from 1 month to 17 years were examined. 204 clinically healthy patients (225 eyes) made up the control group. The remaining 166 children (173 eyes) were diagnosed with various inflammatory diseases: 81 children (85 eyes) had neonatal dacryocystitis; 28 (28 eyes) – acute barley and 57 (60 eyes) – chronic blepharoconjunctivitis. All children underwent conjunctival cavity smear which were cultur

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Manapova, R. M., Alaudin M. Aliskandiev, and M. I. Izrailov. "RISK FACTORS FOR GASTRODUODENAL PATHOLOGY IN CHILDREN WITH PERINATAL DAMAGE TO THE CENTRAL NERVOUS SYSTEM." Russian Pediatric Journal 21, no. 6 (2019): 345–49. http://dx.doi.org/10.18821/1560-9561-2018-21-6-345-349.

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It is generally accepted the risk factors for the development of the gastrointestinal tract (GIT) diseases to have a hereditary predisposition, unfavorable environmental conditions, eating disorders, emotional stress, excessive body weight, and inactivity. Also in a number of studies, it was convincingly shown the perinatal central nervous system (CNS) damage to be a risk factor for the development of GIT diseases; in the history of children with perinatal CNS lesions, chronic gastrointestinal diseases develop 3-4 times more often than in children without it in the history. Perinatal CNS damag

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3

Stanton, Brielle, and Andrea Knight. "Central Nervous System Involvement in Pediatric Systemic Autoimmune Diseases." Journal of Pediatric Neurology 16, no. 03 (2017): 148–63. http://dx.doi.org/10.1055/s-0037-1604061.

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AbstractCentral nervous system (CNS) involvement occurs in many pediatric systemic autoimmune diseases. These manifestations are often associated with increased morbidity and mortality and can have adverse long-term effects on neurodevelopmental, health-related, and quality-of-life outcomes. In this review, we summarize the existing literature on CNS involvement in pediatric systemic autoimmune diseases, compare diagnostic findings, and describe current treatments. CNS manifestations of pediatric systemic autoimmune disease present diagnostic and management challenges due to their relatively r

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Yallapragada, Siva Rama Krishna, Chandra Mohan Pottella, Indla Raviteja, and Sudheer Pasupuleti. "Incidence and Risk Factors of Hypomagnesemia in Critically Ill Children." International Journal of Pharmaceutical and Clinical Research 16, no. 5 (2024): 1203–6. https://doi.org/10.5281/zenodo.12752605.

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<strong>Aim:</strong> To assess incidence and risk factors of hypomagnesemia in critically ill patients. <strong>Methodology:</strong> 76 Paediatric intensive care unit (PICU) admissions, age ranged 1 month- 18 months of both genders were selected and parameters include weight, co-morbidities, metabolic profile (serum sodium, potassium, calcium, magnesium, blood urea nitrogen, creatinine, and blood pH), admission category (cardiac disease, sepsis, renal failure, CNS linked diseases, trauma, and others), and others. A spectrophotometer was used as an endpoint to assess the total

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Kotov, A. S., M. V. Panteleeva, and E. V. Mukhina. "Demyelinating diseases of the central nervous system in children: lecture for practicing pediatricians." Almanac of Clinical Medicine 49, no. 3 (2021): 239–44. http://dx.doi.org/10.18786/2072-0505-2021-49-034.

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Demyelinating diseases (DD) are autoimmune disorders that morphologically manifest mainly with myelin destruction in the central nervous system (CNS). Recently, there has been a continuous increase in DD of the CNS, including those in the pediatric population. Despite the active development of strategies for the diagnosis of DD and verification of its forms, the differential diagnosis of DD and other diseases associated with abnormalities in the brain white matter structure on magnetic resonance imaging continues to be problematic. We examined 123 patients with suspected DD CNS. The diagnosis

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Piskur, Zoriana I., and Lidiia I. Mykolyshyn. "COMORBIDITIES AT THE TUBERCULOSIS AMONG CHILDREN." Wiadomości Lekarskie 74, no. 10 (2021): 2433–38. http://dx.doi.org/10.36740/wlek202110113.

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The aim: To study the structure of clinical forms of tuberculosis (TB) which are combined with the comorbidities, to prevent the development, and to improve the diagnostics of TB among children with nonspecific diseases. Materials and methods: A retrospective, selective research of 330 cards of children for the age group from 0 to 15 years old who were treated on local forms of pulmonary and extrapulmonary TB in a specialized pediatric department for the last 30 years was conducted. Results: Among 92.9 % children with comorbidities, the specific process of respiratory system was detected. Ever

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7

Pakpoor, Julia, Raph Goldacre, Klaus Schmierer, Gavin Giovannoni, Emmanuelle Waubant, and Michael J. Goldacre. "Psychiatric disorders in children with demyelinating diseases of the central nervous system." Multiple Sclerosis Journal 24, no. 9 (2017): 1243–50. http://dx.doi.org/10.1177/1352458517719150.

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Introduction: The profile of psychiatric disorders associated with multiple sclerosis (MS) may differ in children. We aimed to assess the risk of psychiatric disorders in children with MS and other demyelinating diseases, and vice versa. Patients and methods: We analyzed linked English Hospital Episode Statistics, and mortality data, 1999–2011. Cohorts were constructed of children admitted with MS and other central nervous system (CNS) demyelinating diseases. We searched for any subsequent episode of care with psychiatric disorders in these cohorts and compared to a reference cohort. Results:

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8

Li, Yu-Qi, and Chuang Guo. "A Review on Lactoferrin and Central Nervous System Diseases." Cells 10, no. 7 (2021): 1810. http://dx.doi.org/10.3390/cells10071810.

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Central nervous system (CNS) diseases are currently one of the major health issues around the world. Most CNS disorders are characterized by high oxidative stress levels and intense inflammatory responses in affected tissues. Lactoferrin (Lf), a multifunctional iron-binding glycoprotein, plays a significant role in anti-inflammatory, antibacterial, antiviral, reactive oxygen species (ROS) modulator, antitumor immunity, and anti-apoptotic processes. Previous studies have shown that Lf is abnormally expressed in a variety of neurological diseases, especially neurodegenerative diseases. Recently,

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9

Lubarski, Karol, Anna Mania, Katarzyna Mazur-Melewska, and Magdalena Figlerowicz. "Cytokine detection in cerebrospinal fluid in central nervous system diseases in children." Child Neurology 29, no. 59 (2021): 45–50. http://dx.doi.org/10.20966/chn.2020.59.468.

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Cytokine activation and inflammatory process is a result of complex interaction in the pathogenesis of various central nervous system disorders (CNS). Both proinflammatory and anti- -inflammatory cytokines are produced during immune response. Cytokines measurement in the cerebrospinal fluid (CSF) may be used as an additional tool in patients assessment. In the state of CNS infection, IL-1, IL-6, IL-8, IL-10 and TNF-α levels are typically elevated. Cytokine level alterations after antibiotic therapy are not fully elucidated. Some cytokines, like IL-6, are not only an inflammatory parameter, bei

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Posnakoglou, Lamprini, Elizabeth-Barbara Tatsi, Panagiota Chatzichristou, et al. "Molecular Epidemiology of Enterovirus in Children with Central Nervous System Infections." Viruses 13, no. 1 (2021): 100. http://dx.doi.org/10.3390/v13010100.

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Limited recent molecular epidemiology data are available for pediatric Central Nervous System (CNS) infections in Europe. The aim of this study was to investigate the molecular epidemiology of enterovirus (EV) involved in CNS infections in children. Cerebrospinal fluid (CSF) from children (0–16 years) with suspected meningitis–encephalitis (ME) who were hospitalized in the largest pediatric hospital of Greece from October 2017 to September 2020 was initially tested for 14 common pathogens using the multiplex PCR FilmArray® ME Panel (FA-ME). CSF samples positive for EV, as well as pharyngeal sw

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11

Millner, Michael M., Wolfgang Franthal, Gabriela H. Thalhammer, et al. "Neopterin concentrations in cerebrospinal fluid and serum as an aid in differentiating central nervous system and peripheral infections in children." Clinical Chemistry 44, no. 1 (1998): 161–67. http://dx.doi.org/10.1093/clinchem/44.1.161.

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Abstract Neopterin is a sensitive indicator for cellular immune activation. Its concentrations were determined in cerebrospinal fluid (CSF) and serum specimens from 91 children with no evidence of central nervous system (CNS) or peripheral inflammations, 43 with definite neuroborreliosis, 51 with other CNS infections, and 33 with peripheral infections. The aim of our study was (a) to establish a range of normal CSF neopterin concentrations in control children, and (b) to inquire into the diagnostic potential of neopterin measurements in both body compartments for aiding in differential diagnos

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David, Jane Jackie, Syed Ahmed Zaki, and Preeti Shanbag. "Primary neurological manifestations of HIV in children." Journal of Infection in Developing Countries 17, no. 06 (2023): 752–61. http://dx.doi.org/10.3855/jidc.17645.

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Human immunodeficiency virus type 1 (HIV-1) causes various diseases in different age groups. Neurological manifestations of HIV are common and add to morbidity and mortality. It was previously thought that the central nervous system (CNS) was involved only in the advanced stages of the disease. However, recent evidence supports pathological involvement of the CNS from initial viral entry. Some of the CNS manifestations in children share similarities to neurologic disorders of HIV-infected adult patients, while others are unique to the pediatric population. Many HIV-related neurologic complicat

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Toczylowski, Kacper, Magdalena Wieczorek, Ewa Bojkiewicz, Magdalena Wietlicka-Piszcz, Beata Gad, and Artur Sulik. "Pediatric Enteroviral Central Nervous System Infections in Bialystok, Poland: Epidemiology, Viral Types, and Drivers of Seasonal Variation." Viruses 12, no. 8 (2020): 893. http://dx.doi.org/10.3390/v12080893.

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Enteroviruses are common causes of infections of the central nervous system (CNS) that in temperate climates tend to peak in the summer. The aim of the study was to describe epidemiology, drivers of seasonality, and types of enteroviruses causing infections of the CNS in children in Northeastern Poland. We prospectively collected data on children hospitalized with infection of the CNS attributed to enteroviruses in Bialystok, Poland, from January 2015 to December 2019. In total, 224 children were included. Nineteen different enterovirus types were identified in isolates collected from 188 chil

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14

Nassen, R., K. Donald, K. Walker, et al. "Management of mental health disorders and central nervous system sequelae in HIV-positive children and adolescents." Southern African Journal of HIV Medicine 15, no. 3 (2014): 81–96. http://dx.doi.org/10.4102/sajhivmed.v15i3.7.

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HIV-positive children and adolescents are at increased risk of both central nervous system (CNS) sequelae and mental disorders owing to a number of factors, including the impact of HIV infection on the brain, social determinants of health (e.g. poverty and orphanhood) and psychosocial stressors related to living with HIV. Every effort should be made to identify perinatally HIV-infected children and initiate them on antiretroviral therapy early in life. HIV clinicians should ideally screen for mental health and neurocognitive problems, as part of the routine monitoring of children attending ant

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15

Berezovskaya, T. S., N. A. Miromanova, and A. M. Miromanov. "PECULIARITIES OF CLINICAL MANIFESTATIONS OF CNS INFECTIONS IN CHILDREN." Acta Biomedica Scientifica 3, no. 4 (2018): 31–37. http://dx.doi.org/10.29413/abs.2018-3.4.5.

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At present, the neuroinfections in children are a socially significant problem, as they can lead to disability and death.Aim. To reveal the patterns of clinical manifestations of neuroinfections in the children’s central nervous system.Materials and methods. We investigated 91 cases of neuroinfections in children. The children underwent treatment in the Regional Infectious Diseases Hospital (Chita) between 2007 and 2014. Among 91 cases, 32 patients had viral neuroinfections and 59 had bacterial infections.Results. The young boys have bacterial neuroinfections more often. Headaches were found i

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Spinei, Aurelia, Olga Balteanu, Svetlana Plamadeala, Elena Hristea, Iurie Spinei, and Olga Tagadiuc. "Relationship between dental caries and phosphocalcic metabolism in children with severe central nervous system diseases caused by perinatal hypoxia." Journal of Stomatological Medicine, no. 1(61) (February 2023): 67–83. http://dx.doi.org/10.53530/1857-1328.22.61.09.

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The purpose of this paper was to study the relationship between dental caries damage and markers of phosphocalcic metabolism in children with severe diseases of the central nervous system (CNS) caused by perinatal hypoxia. To highlight the impact of metabolic disorders on the susceptibility to dental caries of children with severe CNS disease, were studied the biochemical markers of redox processes, bone and phosphocalcic metabolism in blood serum and oral fluid (OF). The study found a chronic disorder of redox processes, phosphocalcic metabolism at the macro and local level that significantly

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Patel, Dhrumil Deveshkumar, Laura Z. Fenton, Swastika Lamture, and Vinay Kandula. "Pediatric Meningeal Diseases: What Radiologists Need to Know." Tomography 10, no. 12 (2024): 1970–2013. https://doi.org/10.3390/tomography10120143.

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Evaluating altered mental status and suspected meningeal disorders in children often begins with imaging, typically before a lumbar puncture. The challenge is that meningeal enhancement is a common finding across a range of pathologies, making diagnosis complex. This review proposes a categorization of meningeal diseases based on their predominant imaging characteristics. It includes a detailed description of the clinical and imaging features of various conditions that lead to leptomeningeal or pachymeningeal enhancement in children and adolescents. These conditions encompass infectious mening

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Prakash, JohnAntony Jude, Beula Subashini, DebasisDas Adhikari, ValsanPhilip Verghese, Visalakshi Jeyaseelan, and Balaji Veeraraghavan. "CNS infections in children: Experience from a tertiary care center." Journal of Global Infectious Diseases 9, no. 1 (2017): 35. http://dx.doi.org/10.4103/0974-777x.194375.

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19

Ermolenko, K. Yu, Yu S. Aleksandrovich, K. V. Pshenisnov, et al. "Assessing the accuracy of prognostic scales in children with neuroinfections." Infekcionnye bolezni 19, no. 2 (2021): 76–82. http://dx.doi.org/10.20953/1729-9225-2021-2-76-82.

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Accurate assessment of the disease severity and outcome prediction in children with neuroinfections is one of the most challenging problems in pediatric intensive care. Objective. To evaluate performance characteristics of several prognostic scales used in children with infections of the central nervous system (CNS). Patients and methods. We examined 100 children with a mean age of 3.5 years. Mean length of stay in the intensive care unit was 9.5 days; mean duration of ventilation was 6.0 days. The death rate was 11%. To evaluate patients’ condition, we used the following scales: PELOD2, PELOD

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20

Aparicio, Denisse Vaquera, José Iván Castillo Bejarano, Abiel Mascareñas de los Santos, Sergio Ramírez-Cortinas, and Manuel de la O Cavazos. "Case Report: Granulomatous Amebic Encephalitis due to Acanthamoeba spp. in an Immunocompetent Pediatric Patient." American Journal of Tropical Medicine and Hygiene 105, no. 1 (2021): 167–70. http://dx.doi.org/10.4269/ajtmh.21-0129.

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Abstract.Granulomatous amebic encephalitis (GAE) caused by Acanthamoeba is a rare infection with central nervous system (CNS) involvement usually with fatal consequences. Currently, information regarding GAE in children is scarce and is limited only to case reports and case series. A 13-year-old immunocompetent male patient with a 6-month history of progressive and intermittent headaches presented to our institution. One week before hospital admission, the patient showed signs of CNS involvement. Magnetic resonance imaging revealed multiple lesions with supra- and infratentorial cerebral absce

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Andreeva, N. A., and E. V. Kumirova. "Neurobiology of sleep and insomnia in children with CNS tumors." Russian Journal of Children Hematology and Oncology 5, no. 4 (2019): 51–59. http://dx.doi.org/10.17650/2311-1267-2018-5-4-51-59.

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Insomnia is a common symptom in children with malignant diseases and especially in children with tumors of the central nervous system (CNS). However, little attention is paid this complication during the therapy of malignant neoplasms. Insomnia violates the quality of life of children and their immediate surroundings. In this article, the etiology, pathogenesis, and diagnostics are discussed in detail, and methods for treating this pathology are presented with two clinical cases confirming the diverse nature of insomnia in CNS tumors. Thus, the importance of an individual approach to the thera

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Zillner, Clarissa, Agnes Turner, Gerda Rockenbauer, Martin Röhsner, and Thomas Pletschko. "Use of Telepresence Systems to Enhance School Participation in Pediatric Patients with Chronic Illnesses Involving the CNS." Zeitschrift für Neuropsychologie 33, no. 4 (2022): 227–34. http://dx.doi.org/10.1024/1016-264x/a000365.

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Abstract: Background: Due to hospitalization, medical treatment and/or rehabilitation stays, children and adolescents with diseases of the central nervous system (CNS; e.g. tumors, epilepsies or traumatic brain injuries) often cannot participate in everyday school life to the same extent as their peers. To counteract social isolation and negative consequences (e.g. lack of a sense of belonging, reduced well-being and self-esteem, more frequent class repetitions or low educational attainment) telepresence systems are increasingly being discussed as a way to enable participation for children and

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Chahroudi, Ann, Thor A. Wagner, and Deborah Persaud. "CNS Persistence of HIV-1 in Children: the Untapped Reservoir." Current HIV/AIDS Reports 15, no. 5 (2018): 382–87. http://dx.doi.org/10.1007/s11904-018-0412-1.

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Bukhalko, Marina A., Elena Yu Skripchenko, Lidiya A. Alekseeva, Nataliya V. Skripchenko, Nina E. Monakhova, and Stepan G. Grigoriev. "Vitamin D and neurospecific proteins in children with inflammatory demyelinating diseases of central nervous system." Pediatrician (St. Petersburg) 10, no. 3 (2019): 17–24. http://dx.doi.org/10.17816/ped10317-24.

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The relevance of studying the provision of vitamin D in children with inflammatory diseases of the central nervous system (CNS) is due to a high prevalence of vitamin D deficiency conditions in children population, which, according to current literature data, leads to the imbalance of the immune system and a predisposition to a severe disease course, chronization of the process, development of autoimmune pathology. The study of the concentration of neurospecific proteins (NSP) in blood serum and cerebrospinal fluid (CSF) has been recently used to analyze the degree and nature of nervous tissue

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Alisjahbana, Dewi H., Syndi Nurmawati, Mia Milanti, et al. "Central nervous system infection in a pediatric population in West Java." PLOS Neglected Tropical Diseases 17, no. 11 (2023): e0011769. http://dx.doi.org/10.1371/journal.pntd.0011769.

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Central nervous system (CNS) viral infections are critical causes of morbidity and mortality in children; however, comprehensive data on etiology is lacking in developing countries such as Indonesia. To study the etiology of CNS infections in a pediatric population, 50 children admitted to two hospitals in Bandung, West Java, during 2017–2018 were enrolled in a CNS infection study. Cerebrospinal fluid and serum specimens were tested using molecular, serological, and virus isolation platforms for a number of viral and bacteriological agents. Causal pathogens were identified in 10 out of 50 (20%

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Lyubimova, N. A., T. M. Pervunina, K. A. Ciel та M. M. Kostik. "А new coronavirus infection associated CNS involvement in children: literature review and clinical case description". Russian Journal for Personalized Medicine 3, № 2 (2023): 46–56. http://dx.doi.org/10.18705/2782-3806-2023-3-2-46-56.

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Recently, the number of reports and clinical observations of various immune-mediated diseases in children that occur after COVID-19, including those with central nervous system involvememnt, has increased. This review briefly highlights the current knowledge about neurological diseases in children after COVID-19 with a description of a rare post-сovid-19 case of the PANS syndrome in our center.

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Kravchenko, L. V., M. A. Levkovich, S. B. Berezhanskaya, et al. "Clinical and immunological criteria for prediction of thechronic course of cytomegalovirus infection on the background of hypoxic-ischemic damage of the central nervous system in children in the first year of life." HIV Infection and Immunosuppressive Disorders 14, no. 3 (2022): 35–42. http://dx.doi.org/10.22328/2077-9828-2022-14-3-35-42.

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Objective. To develop prognostic criteria for the chronic course of cytomegalovirus infection by studying disorders of the regulation of the immune response in children of the first year of life against the background of hypoxic-ischemic CNS damage.Materials and methods. 108 newborns with cytomegalovirus infection occurring against the background of perinatal hypoxicischemic lesions of the central unequal system were examined. All observed patients at 1 and 3 months of life conducted an immunological examination, including the determination of T and B-lymphocytes. Determination of the populati

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Bykov, Yu. "TYPE 1 DIABETES MELLITUS IN PEDIATRIC PRACTICE AND DAMAGE TO THE CENTRAL NERVOUS SYSTEM." Tavricheskiy Mediko-Biologicheskiy Vestnik 23, no. 4 (2022): 91–97. http://dx.doi.org/10.29039/2070-8092-2020-23-4-91-97.

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Diabetes mellitus (DM) is one of severe and progressive endocrine system diseases that occur in childhood. Type 1 DM, the form most commonly seen in children and adolescents, develops as an autoimmune process that gradually inflicts damage and causes death of pancreatic β cells. During its course MD gives rise to a number of severe complications, the most significant of which is the dysfunction and damage of the central nervous system (CNS). The leading causes of CNS damage in DM can be subdivided into vascular, metabolic, neurodegenerative and inflammatory. The main clinical presentation of D

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Rossi, A., R. Biancheri, E. Lanino, et al. "Neuroradiology of Pediatric Hemolymphoproliferative Disease." Rivista di Neuroradiologia 16, no. 2 (2003): 221–50. http://dx.doi.org/10.1177/197140090301600203.

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Hemolymphoproliferative diseases (HLD) are among the most common causes of morbidity and mortality in children. In the past few years, the increased effectiveness of treatment modalities has significantly increased overall survival, but has also disclosed new aspects of the natural history of these disorders, among which central nervous system (CNS) involvement. CNS complications of HLD can basically be categorized into direct localization of primary disease, indirect effects of malignancy such as cerebrovascular or infectious complications, and iatrogenic side effects. Magnetic resonance imag

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Nevmerzhitskaya, K. S., L. I. Volkova, and M. V. Sergeeva. "Predicting relapse in demyelinating diseases in children." Ural Medical Journal 20, no. 6 (2022): 57–62. http://dx.doi.org/10.52420/2071-5943-2021-20-6-57-62.

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Introduction. Predicting relapse in acute demyelinating episode (ADE) in children is an urgent problem, since progressive demyelinating diseases are associated with the risk of disability and cognitive impairment.Methods. Descriptive cohort study. The results of long-term follow-up of 75 children after the first episode of demyelination are presented. Based on the clinical and radiological parameters of the first demyelinating event, the prognostic factors for the relapse in children were determined using the logistic regression method.Results. When comparing the clinical and instrumental sign

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ZHDANOVHYCH, O. I., O. T. LAKSHA, and O. M. TETERINA. "DYNAMIC OBSERVATION OF THE DEVELOPMENT OF CHILDREN WHOSE MOTHERS SUFFERED INFLUENZA OR ACUTE RESPIRATORY VIRAL INFECTIONS DURING PREGNANCY." Scientific digest of association of obstetricians and gynecologists of Ukraine, no. 2(48) (September 8, 2021): 25–30. https://doi.org/10.35278/2664-0767.2(48).2021.250968.

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Influenza in pregnant women, in addition to medical, has a significant social and demographic significance, since it negatively affects both this pregnancy and the further reproductive function of a woman, causes a violation of the development of the fetus and the condition of the newborns. The aim of the study was to identify the developmental features of children whose mothers had influenza or ARVI during pregnancy. Materials and research methods. A dynamic observation of 68 children was carried out: the first group consisted of 20 children in whom no signs of disorders of cerebral structure

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Sulik, Artur, Kacper Toczylowski, Agnieszka Kulczynska-Przybik, and Barbara Mroczko. "Amyloid and Tau Protein Concentrations in Children with Meningitis and Encephalitis." Viruses 14, no. 4 (2022): 725. http://dx.doi.org/10.3390/v14040725.

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Alzheimer’s disease (AD) has emerged as a growing threat to human health. It is a multifactorial disorder, in which abnormal amyloid beta metabolism and neuroinflammation have been demonstrated to play a key role. Intrathecal inflammation can be triggered by infections and precede brain damage for years. We analyzed the influence of infections of the central nervous system on biomarkers that are crucially involved in AD pathology. Analyses of the cerebrospinal fluid (CSF) levels of Aβ1–42, Aβ1–40, Tau, and pTau proteins were performed in 53 children with neuroinfections of viral (n = 26) and b

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Hooijkaas, H., K. Hahlen, HJ Adriaansen, I. Dekker, GE van Zanen, and JJ van Dongen. "Terminal deoxynucleotidyl transferase (TdT)-positive cells in cerebrospinal fluid and development of overt CNS leukemia: a 5-year follow-up study in 113 children with a TdT-positive leukemia or non- Hodgkin's lymphoma." Blood 74, no. 1 (1989): 416–22. http://dx.doi.org/10.1182/blood.v74.1.416.416.

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Abstract We investigated whether an indirect nuclear terminal deoxynucleotidyl transferase (TdT) immunofluorescence (IF) assay on single cells present in the cerebrospinal fluid (CSF) is more effective than conventional cytomorphology for early detection or exclusion of (minimal) meningeal leukemic infiltration in patients with a TdT+ malignancy. During a 5- year follow-up study, 1,661 consecutive CSF samples from 113 children with a TdT+ acute lymphoblastic leukemia (ALL) (n = 100), a TdT+ acute nonlymphoblastic leukemia (ANLL) (n = 8), or a TdT+ non-Hodgkin's lymphoma (NHL) (n = 5) were anal

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Hooijkaas, H., K. Hahlen, HJ Adriaansen, I. Dekker, GE van Zanen, and JJ van Dongen. "Terminal deoxynucleotidyl transferase (TdT)-positive cells in cerebrospinal fluid and development of overt CNS leukemia: a 5-year follow-up study in 113 children with a TdT-positive leukemia or non- Hodgkin's lymphoma." Blood 74, no. 1 (1989): 416–22. http://dx.doi.org/10.1182/blood.v74.1.416.bloodjournal741416.

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We investigated whether an indirect nuclear terminal deoxynucleotidyl transferase (TdT) immunofluorescence (IF) assay on single cells present in the cerebrospinal fluid (CSF) is more effective than conventional cytomorphology for early detection or exclusion of (minimal) meningeal leukemic infiltration in patients with a TdT+ malignancy. During a 5- year follow-up study, 1,661 consecutive CSF samples from 113 children with a TdT+ acute lymphoblastic leukemia (ALL) (n = 100), a TdT+ acute nonlymphoblastic leukemia (ANLL) (n = 8), or a TdT+ non-Hodgkin's lymphoma (NHL) (n = 5) were analyzed. In

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Ibrahim, Hoda Atef Abdelsattar, Aya Amin, Ahmed Zeid, Samar Sabry, and Hesham Safouh. "A Pattern of Glomerular Diseases in Egyptian Children: A Single-center Experience." Open Access Macedonian Journal of Medical Sciences 9, B (2021): 1305–12. http://dx.doi.org/10.3889/oamjms.2021.7142.

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BACKGROUND: Findings indicative of the glomerular disease are proteinuria, hematuria, nephrotic syndrome (NS), hypertension, and renal insufficiency. These presentations can be used to define different clinical patterns that resemble different underlying etiologies. METHODS: This study is a cross-sectional study enrolled in Children Hospital Cairo University. The study participants were recruited on two stages, retrospective and prospective stages. In the retrospective stage, all eligible patients across 5 years (between 2011 and 2015) with any glomerular disease were included in the study. In

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Paudel, Kiran Mani, and Sindhu Sharma. "Review of Paediatrics Inpatient at a Zonal Hospital." Journal of Nepal Paediatric Society 32, no. 3 (2013): 239–44. http://dx.doi.org/10.3126/jnps.v32i3.7089.

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Introduction: Childhood illnesses cause significant number of admissions in different level hospitals. This retrospective study was undertaken to analyze the morbidity pattern in the Paediatric ward at a Zonal Hospital with aim that the results obtained will help in planning, prioritizing and implementing preventive, promotive and curative health care activities of the children in resource poor community. Materials and Methods: This study was carried out retrospectively for one year from July/Aug 2010 – June/July 2011. Age, sex, diagnosis, month of admission, duration of admission and the freq

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Barua, Sanat Kumar, Kiriti Prashad Deb, Arup Dutta, Nasir Uddin Mahmud, Pranab Kumar Chowdhury, and Sharmila Barua. "Disease Profile and Outcome of Patients Admitted to A Pediatric Intensive Care Unit." Journal of Chittagong Medical College Teachers' Association 29, no. 1 (2018): 11–16. http://dx.doi.org/10.3329/jcmcta.v29i1.62464.

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Background: Pediatric Intensive Care Unit (PICU) has very important role in the management of critically ill children who require advanced airway, respiratory, and hemodynamic supports with the aim of achieving a better outcome. To describe the clinical spectrum and outcome patterns of diseases managed at PICU in Chittagong Medical College Hospital (CMCH) in order to provide data, which will assist in improving the management of diseases and the rational allocation of health resources. Materials and methods: It was a retrospective crosssectional study in which records of admissions of children

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Abo, Yara-Natalie, Nigel Curtis, Joshua Osowicki, et al. "Infliximab for Paradoxical Reactions in Pediatric Central Nervous System Tuberculosis." Journal of the Pediatric Infectious Diseases Society 10, no. 12 (2021): 1087–91. http://dx.doi.org/10.1093/jpids/piab094.

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Abstract Paradoxical reactions in central nervous system tuberculosis (CNS-TB) are associated with significant morbidity and mortality. We describe 4 HIV-uninfected children treated for CNS-TB with severe paradoxical reactions unresponsive to corticosteroids. All made recovery after treatment with infliximab, highlighting the safety and effectiveness of infliximab for this complication, and need for prospective trials.

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D’Alessandro, Rossella, Neftj Ragusa, Martina Vacchetti, et al. "Assessing Cognitive Function in Neuromuscular Diseases: A Pilot Study in a Sample of Children and Adolescents." Journal of Clinical Medicine 10, no. 20 (2021): 4777. http://dx.doi.org/10.3390/jcm10204777.

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Central nervous system (CNS) involvement has been variously studied in pediatric neuromuscular disorders (NMDs). The primary goal of this study was to assess cognitive functioning in NMDs, and secondary aims were to investigate possible associations of cognitive impairment with motor impairment, neurodevelopmental delay, and genotype. This was a cross-sectional study of 43 pediatric patients, affected by six NMDs. Myotonic dystrophy type 1 (DM1) and glycogen storage disease type 2 (GSD2) patients had a delay on the Bayley-III scales. On Wechsler scales, DMD and DM1 patients showed lower FSIQ s

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Alnaami, Ibrahim, and Zubaidah Alahmari. "Intrathecal/Intraventricular Colistin for Antibiotic-Resistant Bacterial CNS Infections in Pediatric Population: A Systematic Review." Tropical Medicine and Infectious Disease 7, no. 3 (2022): 41. http://dx.doi.org/10.3390/tropicalmed7030041.

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Central nervous system (CNS) infections constitute a life-threatening condition, especially in children. Treatment limitations exist for drug-resistant CNS bacterial infections. Inadequate CNS penetration and intravenous (IV) antibiotic treatment failure represent a major clinical challenge. However, patients with antibiotic-resistant bacterial CNS infections may benefit from intrathecal (IT) or intraventricular (IVT) colistin. The authors aimed to assess the safety and effectiveness of IT/IVT colistin therapy in the pediatric population, with or without other antibiotics, for the treatment of

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Sorokovikova, T. V., L. V. Chichanovskaya, T. V. Menshikova, et al. "Current concepts of hypoxic-ischemic CNS lesions." Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery), no. 6 (May 28, 2025): 742–51. https://doi.org/10.33920/med-01-2506-04.

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Hypoxic-ischemic lesions occur in premature and preterm infants and lead to disorders of the central nervous system, with the main cause of this condition being perinatal asphyxia. Modern statistical data indicate that approximately every second newborn with systemic hypoxia in the perinatal period has morphofunctional CNS disorders. Currently, asphyxia is the third most common cause of neonatal mortality, with prematurity and severe infectious diseases ranking first and second. Hypoxic-ischemic encephalopathy occurring in the neonatal period causes abnormalities in the development of the nerv

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Upadhyay, S., A. Sharma, P. Rijal, and S. Shrestha. "Review of Paediatrics In-Patient at Nepal Medical College and Teaching Hospital." Journal of Nepal Paediatric Society 31, no. 1 (2011): 25–29. http://dx.doi.org/10.3126/jnps.v31i1.3262.

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Introduction: This retrospective study was undertaken to analyze the disease pattern in the Pediatric ward in a Medical College. After analyzing the data, our study would emphasize on the prevention and the management modality of the most prevalent diseases in the community. Methodology: This study was carried out retrospectively for one year from January 2008 - December 2008 on the basis of age and sex and the frequency of disease according to the system involved. Results: A total number of 453 patients were admitted during the study period. There were 267(59%) male and 186(41%) female childr

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Morichi, Shinichiro, Hisashi Kawashima, Hiroaki Ioi, et al. "Cerebrospinal fluid NOx (nitrite/nitrate) in RSV-infected children with CNS symptoms." Journal of Infection 59, no. 4 (2009): 299–301. http://dx.doi.org/10.1016/j.jinf.2009.07.008.

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Skouboe, Morten Kelder, Marvin Werner, and Trine H. Mogensen. "Inborn Errors of Immunity Predisposing to Herpes Simplex Virus Infections of the Central Nervous System." Pathogens 12, no. 2 (2023): 310. http://dx.doi.org/10.3390/pathogens12020310.

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Herpesvirus infections can lead to a number of severe clinical manifestations, particularly when involving the central nervous system (CNS), causing encephalitis and meningitis. However, understanding of the host factors conferring increased susceptibility to these diseases and their complications remains incomplete. Previous studies have uncovered defects in the innate Toll-like receptor 3 pathway and production of type I interferon (IFN-I) in children and adults that predispose them to herpes simplex encephalitis. More recently, there is accumulating evidence for an important role of IFN-ind

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van Engelen, B. G., K. J. Lamers, F. J. Gabreels, R. A. Wevers, W. J. van Geel, and G. F. Borm. "Age-Related Changes of Neuron-Specific Enolase, S-100 Protein, and Myelin Basic Protein Concentrations in Cerebrospinal Fluid." Clinical Chemistry 38, no. 6 (1992): 813–16. http://dx.doi.org/10.1093/clinchem/38.6.813.

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Abstract Studies on cerebrospinal fluid (CSF) concentrations of neuron-specific enolase (NSE), S-100 protein, and myelin basic protein (MBP) in patients with neurological lesions indicate a quantitative relation between the degree of cell damage in the central nervous system (CNS) and the concentration of these CNS-specific proteins in CSF. Thus NSE, S-100, and MBP could be of use as markers for destructive processes in the CNS. We collected 937 specimens of CSF from children and adults (from newborns to age 91 years) who were undergoing a diagnostic lumbar puncture for several clinical indica

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Costa, Maria da Conceição N., Luciana Lobato Cardim, Cynthia A. Moore, et al. "Causes of death in children with congenital Zika syndrome in Brazil, 2015 to 2018: A nationwide record linkage study." PLOS Medicine 20, no. 2 (2023): e1004181. http://dx.doi.org/10.1371/journal.pmed.1004181.

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Background Children with congenital Zika syndrome (CZS) have severe damage to the peripheral and central nervous system (CNS), greatly increasing the risk of death. However, there is no information on the sequence of the underlying, intermediate, immediate, and contributing causes of deaths among these children. The aims of this study are describe the sequence of events leading to death of children with CZS up to 36 months of age and their probability of dying from a given cause, 2015 to 2018. Methods and findings In a population-based study, we linked administrative data on live births, death

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Petrova, Nataliya G., and Viktoria A. Yarovaya. "Effective rehabilitation of children with perinatal lesions of the central nervous system." Medical and Social Expert Evaluation and Rehabilitation 26, no. 1 (2023): 25–35. http://dx.doi.org/10.17816/mser121840.

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BACKGROUND: Perinatal lesions of the central nervous system (CNS) prevail among other diseases of the nervous system in children, and are an economic burden on society and public health systems. The challenge in these cases is improving the quality of life of children with perinatal hypoxic pathology, which requires long-term nursing, treatment, and rehabilitation. The level of childhood disability remains consistently high, so improving the assistance to children with disabilities is an important state task. OBJECTIVE: The analysis of the results of rehabilitation treatment. MATER

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Kirgizov, K. I., E. Y. Volkova, S. V. Piliya, et al. "EFFICACY OF HIGH-DOSAGE THERAPY FOR AUTOIMMUNE DISEASES OF THE CNS IN CHILDREN: THE EXPERIENCE." Pediatria. Journal named after G.N. Speransky 98, no. 2 (2019): 214–20. http://dx.doi.org/10.24110/0031-403x-2019-98-2-214-220.

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Di Pauli, Franziska, Markus Reindl, and Thomas Berger. "New clinical implications of anti-myelin oligodendrocyte glycoprotein antibodies in children with CNS demyelinating diseases." Multiple Sclerosis and Related Disorders 22 (May 2018): 35–37. http://dx.doi.org/10.1016/j.msard.2018.02.023.

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Chen Ling and Wang Shu-xue. "Significance and measurement of myelin basic protein antibody in CSF from children with CNS diseases." Pediatric Neurology 8, no. 5 (1992): 393. http://dx.doi.org/10.1016/0887-8994(92)90279-8.

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