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Dissertations / Theses on the topic 'Choroidal'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Berglin, Lennart. "Choroidal neovascularization (CNV) : clinical and experimental aspects /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-284-1/.

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2

Balaggan, K. S. "Development of gene therapy for choroidal neovascularisation." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1335615/.

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Exudative age-related macular degeneration, characterised by choroidal neovascularisation (CNV), is the leading cause of severe visual impairment in developed societies. Until recently, established treatments were of limited efficacy, and associated with other disadvantages including being inherently destructive therapies. Although novel anti-VEGF pharmacotherapy has since revolutionised the management and prognosis of many patients, current treatment regimens have distinct limitations, particularly in terms of the probable requirement for life-long, frequent invasive dosing, and associated cu

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3

Gardner, Dustin J. "Investigation of Myopic Periphery Affecting Choroidal Thickness." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366286421.

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4

Mäkitie, Teemu. "Prognostic indicators in choroidal and ciliary body melanoma." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/makitie/.

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5

Boonarpha, N. "Choroidal structure and function in chronic retinal diseases." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3001786/.

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Introduction: The choroid plays an important role in maintaining retinal homeostasis. Changes in choroidal structure and a failure of choroidal autoregulation (the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure) may have a great consequence in the pathogenesis of several chronic chorioretinal diseases including diabetic retinopathy (DR) and central serous chorioretinopathy (CSCR). Aim: The main aim of this thesis is to study the structure and function of the choroid and determine its role in the pathogenesis of DR and CSCR using enhanced depth imaging op

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6

Wolfe, Jeremy Dean. "Vessel Formation and Feeder Vessel Treatment in Choroidal Neovascularization." University of Toledo Health Science Campus / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=mco1095878383.

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7

Skeie, Jessica Marie. "Choroidal endothelial cell activation in age-related macular degeneration." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/602.

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Age-related macular degeneration (AMD) is a devastating ocular disease affecting one third of the elderly population in the western world. Some cases of AMD develop neovascular membranes, which are characterized by the pathologic growth of new blood vessels into the retina. This pathology may be initiated by proteins capable of activating endothelial cells to become angiogenic or inflammatory, later causing them to grow abnormally. This investigation aimed to determine the causes of pathologic blood vessel growth in AMD. Human eyes with AMD have been shown by us and others to have abnormal act

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8

Tatar, Olcay. "Immunohistopathologic evaluation of choroidal neovascular membranes following verteporfin photodynamic therapy." München Verl. Dr. Hut, 2008. http://d-nb.info/988623897/04.

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9

Miyamoto, Hideki. "Effect of Focal X-ray Irradiation on Experimental Choroidal Neovascularization." Kyoto University, 1999. http://hdl.handle.net/2433/181752.

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10

Lotery, Andrew John. "A clinical and molecular genetic study of central areolar choroidal dystrophy." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394467.

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11

Tanemura, Mai. "The role of estrogen and estrogen receptor β in choroidal neovascularization". Kyoto University, 2005. http://hdl.handle.net/2433/144767.

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12

Kamizuru, Hiroshi. "Monoclonal antibody-mediated drug targeting to choroidal neovascularization in the rat." Kyoto University, 2003. http://hdl.handle.net/2433/148716.

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13

Alexander, Nadine. "Novel strategies for the cultivation of human choroidal vascular endothelial cells from cadaveric eye tissue." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/115014/1/115014_8878871_nadine_alexander_thesis.pdf.

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The aberrant growth of blood vessels in the posterior segment of the eye is a major symptom of age-related macular degeneration (AMD), the leading cause of irreversible blindness in the developed world. This project has enabled a significant step forward in the study of blood vessels that become diseased in patients suffering from AMD. In doing so, a previously uncharacterised cell type was identified, and with further refinement, could lead to potential novel strategies for wet-AMD therapies.

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14

Sandinha, Teresa. "Prognostic assessment of choroidal melanoma based on interphase cytogenetics and pathological features." Thesis, University of Glasgow, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437993.

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15

Terry, Louise. "An in vivo investigation of choroidal vasculature in age-related macular degeneration." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/107459/.

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Age-related macular degeneration (AMD) is the leading cause of visual impairment in the developed world. Whilst the pathogenesis is complex and not fully understood, changes to the choroidal vasculature in AMD have been demonstrated using histology. Advances in imaging technology, particularly long-wavelength optical coherence tomography (OCT), allow in vivo visualisation and investigation of this structure. The aim of this work is to determine whether changes to the choroidal vasculature are detectable in AMD using in vivo imaging. This was achieved through the evaluation of parameters for qu

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16

Wakazono, Tomotaka. "RECURRENCE OF CHOROIDAL NEOVASCULARIZATION LESION ACTIVITY AFTER AFLIBERCEPT TREATMENT FOR AGE-RELATED MACULAR DEGENERATION." Kyoto University, 2018. http://hdl.handle.net/2433/232093.

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17

Kuroda, Yoshimasa. "Increased Choroidal Vascularity in Central Serous Chorioretinopathy Quantified Using Swept-Source Optical Coherence Tomography." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225496.

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18

Woronkowicz, M. A. "Local and systemic factors impacting on anatomical and functional results of treatment in choroidal neovascularization." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10047189/.

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The work in this thesis analyzed anatomical and functional outcomes of treatment in choroidal neovascularization secondary to the three main causes i.e. age-related macular degeneration, pathological myopia and ocular inflammatory conditions. The first study assessed a value of a global macular status of ELM and EZ as a predictor of treatment response in 71 eyes with neovascular AMD switched to aflibercept treatment due to persistent fluid despite ranibizumab injections. Prior to commencement of aflibercept the eyes received a median number of 12 (IQR: 6-18) ranibizumab injections according to

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19

Sufian, Elfandi. "CLINICAL AND GENETIC CHARACTERISTICS OF JAPANESE PATIENTS WITH AGE-RELATED MACULAR DEGENERATION AND PSEUDODRUSEN." Kyoto University, 2018. http://hdl.handle.net/2433/232120.

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20

Case, Bruce W. "Rapid hypothesis testing and generation for a rare cancer : a case-control study of choroidal melanoma." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=64492.

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21

Dumskyj, Martin John. "Aspects of the control of the retinal and choroidal circulations in normal and diabetic human subjects." Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326746.

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22

Hirashima, Takako. "Choroidal Vasculature in Bietti Crystalline Dystrophy With CYP4V2 Mutations and in Retinitis Pigmentosa With EYS Mutations." Kyoto University, 2020. http://hdl.handle.net/2433/253205.

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23

Nakata, Isao. "Genetic Variants in Pigment Epithelium-Derived Factor Influence Response of Polypoidal Choroidal Vasculopathy to Photodynamic Therapy." Kyoto University, 2013. http://hdl.handle.net/2433/174798.

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24

Ueda, Naoko. "Macular Choroidal Thickness and Volume of Eyes With Reticular Pseudodrusen Using Swept-Source Optical Coherence Tomography." Kyoto University, 2016. http://hdl.handle.net/2433/215412.

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Final publication is available at http://www.sciencedirect.com/science/article/pii/S0002939414000488<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第19586号<br>医博第4093号<br>新制||医||1014(附属図書館)<br>32622<br>京都大学大学院医学研究科医学専攻<br>(主査)教授大森孝一, 教授宮本享, 教授横出正之<br>学位規則第4条第1項該当

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25

Hirani, Anjali A. "Corticosteroid-Encapsulated Nanoparticles in Thermoreversible Gels for the Amelioration of Choroidal Neovascularization in Age-Related Macular Degeneration." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/73318.

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Age-related macular degeneration (AMD) is one of the leading causes of blindness in adults over the age of 60. Currently, at least 11 million patients in the United States have some form of macular degeneration and this number is projected to grow as the population ages. The more severe form of the disease – neovascular (wet) AMD, is characterized by intraocular neovascularization, inflammation, and retinal damage; however, the disease progression can be deterred through intraocular injections of anti-angiogenic agents. The complications and burden that arise from repetitive injections as well

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26

Rice, James C. "Brachytherapy and endoresection in the treatment of choroidal melanoma a review of patients treated in South Africa." Master's thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/10758.

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Includes bibliographical references.<br>This study is a retrospective cohort analysis of patients undergoing two different treatment modalities (brachytherapy and endoresection) for medium sized choroidal melanoma. Study methods involve the collection of baseline and follow-up data from three sources: 1) A database collected by the department of Radiation Oncology at Groote Schuur Hospital; 2) Private physicians responsible for patient follow-up following brachytherapy; 3) Private physicians responsible for endoresection surgery and patient follow-up. To date there has been limited publication

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27

Lytle, Grace E. "Effects of various nitric oxide synthase inhibitors on the choroidal and growth responses in emmetropization in chicks /." Adobe Acrobat Reader required to view document, 2008. http://www.neco.edu/library/theses/LytleThesisJune08.pdf.

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28

Barsha. "Optical coherence tomography angiography assessment of retinal and choroidal vasculature: Diurnal and longitudinal changes and refractive error." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/236553/1/Barsha%2BThesis%281%29.pdf.

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This research measured normal short-term, diurnal, changes, and longer-term changes across a year, in retinal and choroidal blood vessels, using optical coherence tomography angiography (OCT-A). It is the first research to show significant diurnal changes in retinal and choroidal OCT-A indices in healthy young adults, changes that differed between myopic and non-myopic patients. It also found that retinal OCT-A indices changes across a year in children but not adults. OCT-A measures of choroidal blood vessels were stable across the year in both adults and children. These findings benchmark nor

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29

Yasukawa, Tsutomu. "Targeted Delivery of Anti-Angiogenic Agent TNP-470 Using Water-Soluble Polymer in the Treatment of Choroidal Neovascularization." Kyoto University, 2000. http://hdl.handle.net/2433/180865.

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30

Terasaki, Hiroko. "Rescue of retinal function by macular translocation surgery in age-related macular degeneration and other diseases with subfoveal choroidal neovascularization." Nagoya University School of Medicine, 2001. http://hdl.handle.net/2237/5362.

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31

Aldossari, Hussain Mubarak D. "Accommodation effects on peripheral ocular biometry." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/95486/1/Hussain%20Mubarak%20D_Aldossari_Thesis.pdf.

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The effect of near work on the biometric properties of the eye, including the eye’s length and the thickness of the posterior vascular layer were investigated. Short-sighted eyes had greater increases in length and greater thinning of the vascular layer when focused on close objects than did normally-sighted eyes. These changes occurred across the horizontal meridian of the eye and were greatest at the posterior pole. These ocular effects of focusing may partly explain the influence of close work on development of short-sightedness.

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32

Lan, Weizhong [Verfasser], and Frank [Akademischer Betreuer] Schäffel. "Effect of bright light on the changes of choroidal thickness in chickens as measured with OCT / Weizhong Lan ; Betreuer: Frank Schäffel." Tübingen : Universitätsbibliothek Tübingen, 2013. http://d-nb.info/1160684391/34.

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33

Nassar, Khaled [Verfasser]. "Pathogenesis of age related macular degeneration (AMD) : immunohistochemical evaluation of the macrophage activation pattern in human choroidal neovascular membranes / Khaled Nassar." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2011. http://d-nb.info/1013911296/34.

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34

Steén, Björn. "Matrix metalloproteinases and their inhibitors in ocular neovascularization /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-712-6/.

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35

Medina, Flavio Mac Cord 1978. "Associação do polimorfismo Y402H do gene CFH com o tratamento da degeneração macular relacionada à idade com antiangiogênicos." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310113.

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Orientador: José Paulo Cabral de Vasconcellos<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-24T03:32:34Z (GMT). No. of bitstreams: 1 Medina_FlavioMacCord_D.pdf: 2571030 bytes, checksum: 442e6e86f7bd3a0d6fae088740a1e85e (MD5) Previous issue date: 2013<br>Resumo: Introdução: O fator de complemento H (CFH) é um componente do sistema imunológico que possui ação imunomoduladora sobre a resposta inflamatória. A gravidade da degeneração macular relacionada à idade (DMRI) é determinada em parte por um estado inflamatório

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36

Chakraborty, Ranjay. "Diurnal variation of ocular biometrics under natural and defocused conditions." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/61093/1/Ranjay_Chakraborty_Thesis.pdf.

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It is well known that a broad range of ocular anatomical and physiological parameters undergo significant diurnal variation. However, the natural diurnal variations that occur in the length of the human eye (axial length) and their underlying causes have been less well studied. Improvements in optical methods for the measurement of ocular biometrics now allow more precise and comprehensive measurements of axial length to be performed than has previously been possible. Research from animal models also suggests a link between diurnal axial length variations and longer term myopic eye growth, and

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37

DEL, NOCE CHIARA. "Evaluation of retinal, choroidal and peripapillary vascular flow in patients with Thyroid Associated Ophthalmopathy (TAO) using Optical Coherence Tomography Angiography (OCT-A)." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1075633.

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Purpose: The aim of this study was to evaluate changes in choroidal thickness and in choroidal vascular blood flow in patients with TAO and their relationship with clinical features and disease activity using SD-OCT and Angio-OCT technology. Methods: Eighteen patients and control subjects underwent a complete eye examination, OCT and angio - OCT. We also obtained angiographic scans at 3 different consecutive levels (L1, L2 and L3) below the choriocapillary. Results: The subfoveal choroid was significantly thicker in TAO patients than the control eyes (285.6275 ± 32.5 μm compared to 135.89 ±

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38

Abdolrahimzadeh, Solmaz. "The role of optical coherence tomography (OCT) in retinal and choroidal pathology with a focus on intravitreal anti-vascular endothelial growth factor therapy." Thesis, University of Kent, 2016. https://kar.kent.ac.uk/57938/.

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Optical coherence tomography (OCT) is an imaging method for non-invasive, in vivo visualisation of the choroid and retina. The advent of OCT has greatly contributed to the understanding of disease mechanisms in retinal and choroidal pathology. It is used in clinical practice and in the management of intravitreal therapy. We contributed novel findings on choroidal nodules, peripapillary retinal nerve fibre alterations, and retinal microvascular changes in neurofibromatosis type 1 (NF1) using OCT. Furthermore, we studied the relationship of choroidal thickness on individual retinal layer thickne

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39

Sander, Beata P. "The influence of the autonomic nervous system on the human choroid." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/114124/1/Beata_Sander_Thesis.pdf.

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Short-sightedness occurs due to excessive growth of the eye. This research provided new insights into the role of the autonomic nervous system in the control of eye growth by blocking neural signals involved in the eye's response to blur. Pharmacological interventions were examined including adrenergic agonists and muscarinic blockers, while additional mixed interventions included optical blur combined with drugs. The eye's short-term response was assessed through measurements of eye length and the thickness of the choroid. Muscarinic blockers reduced the eyes response to hyperopic blur but di

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40

Tillner, Johanna [Verfasser]. "Radiation retinopathy and optic neuropathy after proton beam therapy of choroidal melanoma : A retrospective analysis of the Incidence, predictive factors and visual outcome / Johanna Tillner." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1127045350/34.

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41

Renganathan, Kutralanathan. "Oxidative Damage and Age Related Macular Degeneration." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1193002743.

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42

Hoseini, Yazdi Seyed Hosein. "Spatial characteristics of the response of the human choroid to imposed defocus." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/120362/1/Seyed%20Hosein_Hoseini%20Yazdi_Thesis.pdf.

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This thesis examined the thickness of the human choroid across a substantially larger region (~55°) than previously examined (~17°), its regional variation associated with myopia, and its short-term response to different spatial patterns of optical defocus. This research provided the first evidence of a local response of the choroid to a region specific pattern of myopic defocus in the human eye. These findings add to the current understanding of the choroid's contribution to vision dependent mechanisms of human eye growth and may assist in optimising the optical design of myopia control inter

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43

Pierce, Charles. "The role of the gene SERPINH1 as a pharmacogenetic biomarker for choroidal neovascularization (CNV) responses to anti vascular endothelial growth factor (VEGF) treatment in clinical practice." Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/417281/.

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Age related macular degeneration is the commonest cause of blindness in the western world and current treatment regimens represent a significant output for national health services. The disease process is multifactorial in origin and has a variable progression and response to current methods of treatment. A targeted approach with individualized therapy based on recognized biomarkers to predict disease outcome would be the ideal treatment modality. We plan to investigate the role of genes known to influence the progression of early AMD to the advanced stage (wet AMD) with emphasis on genes invo

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44

Wijeyakumar, Wijeyanthy. "Choroid Involvement and Intravitreal Aflibercept on Anti-VEGF Treatment-Resistant Neovascular Age-Related Macular Degeneration." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27514.

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PURPOSE: To prospectively report changes in vision related quality of life (VR-QoL) and sub-foveal central choroidal thickness (CCT) following aflibercept therapy in neovascular age-related macular degeneration (nAMD) patients resistant to other anti-VEGF drugs. METHODS: 49 patients with nAMD resistant to other anti-VEGF drugs were treated with 3 monthly intravitreal aflibercept loading doses followed by injections every 8 weeks for 48 weeks. Full ophthalmic examinations including best corrected visual acuity (BCVA) in Early Treatment of Diabetic Retinopathy Study (ETDRS) letters. Central m

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45

BIANCHI, Lívia Carla de Souza Nassar. "Avaliação da eficácia e segurança do uso de radioterapia intraocular com estrôncio 90 e bevacizumabe no tratamento de pacientes portadores de degeneração macular relacionada à idade, forma exsudativa." Universidade Federal de Goiás, 2012. http://repositorio.bc.ufg.br/tede/handle/tde/1748.

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Made available in DSpace on 2014-07-29T15:29:14Z (GMT). No. of bitstreams: 1 Dissertacao Livia C de S N Bianchi - Oftalmologia.pdf: 3291987 bytes, checksum: bf690044678ae1c1ecf40768b3ef062a (MD5) Previous issue date: 2012-03-27<br>Purpose: To evaluate the efficacy and safety of strontium-90 epimacular brachytherapy combined with intravitreal bevacizumab for treating subfoveal choroidal neovascularization secondary to exudative age-related macular degeneration. Its effects on visual acuity and macular thickness at 36 months of follow up were also studied. Methods: Sixteen patients with predom

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46

ABDALLAH, A. ELLABBAN. "Three-Dimensional Tomographic Features of Dome-Shaped Macula by Swept-Source Optical Coherence Tomography." Kyoto University, 2015. http://hdl.handle.net/2433/199164.

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47

WEISSLINGER, JEAN-MARIE. "Contribution a l'etude des metastases choroidiennes : etude de 28 cas personnels." Lille 2, 1992. http://www.theses.fr/1992LIL2M177.

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48

Marques, João Henrique Oliveira Saldanha. "Characterization of Polypoidal Choroidal Vasculopathy." Master's thesis, 2016. https://repositorio-aberto.up.pt/handle/10216/88892.

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49

Pinto, João Pedro Viana Ferreira. "Choroidal thickness in keratoconus patients." Master's thesis, 2018. https://hdl.handle.net/10216/112420.

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50

Marques, João Henrique Oliveira Saldanha. "Characterization of Polypoidal Choroidal Vasculopathy." Dissertação, 2016. https://repositorio-aberto.up.pt/handle/10216/88892.

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