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Dissertations / Theses on the topic 'Chromatid cohesion'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Liu, Zhe. "Characterization of sister chromatid cohesins having overlapping function and the role of separase, AtESP1, in controlling sister chromatid cohesion in Arabidopsis." Connect to this document online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1134155133.

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Thesis (Ph. D.)--Miami University, Dept. of Chemistry and Biochemistry, 2005.<br>Title from second page of PDF document. Document formatted into pages; contains [3], vi, 124 p. : ill. Includes bibliographical references.

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2

Almedawar, Seba. "A SUMO-dependent step during establishment of Sister Chromatid Cohesion." Doctoral thesis, Universitat de Lleida, 2013. http://hdl.handle.net/10803/123807.

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Els anells de cohesina, formats per les proteïnes Smc1, Smc3, Scc1 i Scc3, s’uneixen topològicament al DNA, mantenint les parelles de cromàtides germanes unides des de la duplicació del DNA fins al començament de l’anafase. Aquesta funció, coneguda com a Cohesió entre Cromàtides Germanes, permet la biorientació dels cromosomes en el fus mitòtic i, posteriorment, la seva correcta segregació. Es tracta per tant d’una funció fonamental per a la vida. La cohesió entre cromàtides germanes també té altres funcions, com ara afavorir la reparació del dany en el DNA a través de recombinació homòloga. É

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3

Page, Andrea Wilder. "The meiotic cell cycle and sister-chromatid cohesion in Drosophila oocytes." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/9843.

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4

Borges, V. S. F. "Establishment of sister chromatid cohesion during DNA replication in Saccharomyces cerevisiae." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1370644/.

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Establishment of sister chromatid cohesion is a process thought to occur as the replication fork passes chromosomal loci bound by the cohesin complex. After fork passage, cohesin holds together pairs of replication products to allow their recognition by the mitotic machinery for segregation into daughter cells. In budding yeast, cohesin is loaded onto chromosomes during the G1 phase of the cell cycle. During S phase, the replication fork-associated acetyltransferase Eco1 acetylates the cohesin subunit Smc3 to promote the establishment of sister chromatid cohesion. At the time of anaphase, Smc3

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5

Sundaramoorthy, S. "Mediators of pre-mRNA splicing regulate sister chromatid cohesion in mammalian cells." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1418244/.

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The ‘endless forms most beautiful’ that populate our planet rely on the process of cell division to ensure equal segregation of the cellular content including the DNA to the two daughter cells. The accurate segregation of chromosomes in eukaryotes relies on connection between replicated sister chromatids, a phenomenon known as sister chromatid cohesion. Sister chromatid cohesion is mediated by a conserved ring-like protein complex known as cohesin. Defects in this process can promote aneuploidy and contribute to meiotic segregation errors with adverse consequences for developing embryos. Despi

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6

Vickridge, Elise. "Management of E. coli sister chromatid cohesion in response to genotoxic stress." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS172/document.

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La réplication fidèle de l’ADN au cours du cycle cellulaire est essentielle au maintien de l’intégrité du génome à travers les générations. Toutefois, de nombreux éléments peuvent perturber et compromettre la réplication et donc cette intégrité. La mitomycine C (MMC) est une molécule génotoxique utilisée en chimiothérapie. Elle forme des liaisons covalentes entre les deux brins d’ADN, ce qui est un obstacle à la bonne réplication de l’ADN. La rencontre de la fourche de réplication avec une liaison covalente entre les deux brins d’ADN va aboutir à une cassure double brin. Escherichia coli (E.co

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7

Vickridge, Elise. "Management of E. coli sister chromatid cohesion in response to genotoxic stress." Electronic Thesis or Diss., Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS172.

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La réplication fidèle de l’ADN au cours du cycle cellulaire est essentielle au maintien de l’intégrité du génome à travers les générations. Toutefois, de nombreux éléments peuvent perturber et compromettre la réplication et donc cette intégrité. La mitomycine C (MMC) est une molécule génotoxique utilisée en chimiothérapie. Elle forme des liaisons covalentes entre les deux brins d’ADN, ce qui est un obstacle à la bonne réplication de l’ADN. La rencontre de la fourche de réplication avec une liaison covalente entre les deux brins d’ADN va aboutir à une cassure double brin. Escherichia coli (E.co

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8

Lee, Janice Ying 1974. "Localization studies of sister-chromatid cohesion proteins MEI-S332 and RAD21 in Drosophila." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/32256.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.<br>Includes bibliographical references.<br>In cell division, the proper segregation of chromosomes requires sister-chromatid cohesion. This physical attachment between sister chromatids is established during DNA replication, maintained throughout mitosis and released at the metaphase-anaphase transition. In meiosis, sister-chromatid cohesion is released along the chromosome arms in the first meiotic division, but retained at the centromere until the second meiotic division. In this thesis, we have analyzed the loca

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9

BOATENG, KINGSLEY A. "STUDIES ON ARABIDOPSIS PROTEINS REQUIRED FOR THE ESTABLISHMENT AND RELEASE OF SISTER CHROMATID COHESION." Miami University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=miami1185209243.

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10

Tang, Tracy Tzu-Ling 1971. "The Drosophila centrometic protein MEI-S332 : its role and regulation in sister-chromatid cohesion." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/85285.

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11

Feytout, Amélie. "Régulation dynamique de l’association des cohésines aux chromosomes, établissement et maintien de la cohésion des chromatides sœurs." Thesis, Bordeaux 2, 2010. http://www.theses.fr/2010BOR21773/document.

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Le complexe cohésine maintient associées les chromatides sœurs depuis la réplication jusqu’à leur ségrégation en mitose. Une question majeure est de comprendre comment la cohésion est établie lors de la phase S. Chez les mammifères et S. pombe, les cohésines sont associées de manière labile aux chromosomes pré-réplicatifs et l’établissement de la cohésion en phase S s’accompagne de la stabilisation de l’association des cohésines aux chromosomes. L’objectif de ce travail est de comprendre comment la dynamique des cohésines est régulée et comment son inhibition créée la cohésion.En G1 les cohési

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12

Fumasoni, M. "REPLICATION-ASSOCIATED REPRIMING AND PRIMER PROCESSING FACILITATE ERROR-FREE DNA DAMAGE TOLERANCE AND SISTER CHROMATID SYNAPSIS." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/234145.

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DNA damage tolerance (DDT) mechanisms are crucial for genome integrity as they allow efficient bypass of endogenously or exogenously generated lesions. Error-free bypass of lesions is accomplished by a recombination-related mechanism, generally referred to as template switching (TS), that allows the recovery of the damaged information from the sister chromatid. Pioneer studies revealed key enzymatic functions required for error-free DDT and identified sister chromatid junctions (SCJs) as crucial DNA intermediates mediating this process. However, little is known on the temporal window and the c

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13

Yang, Chao [Verfasser], and Arp [Akademischer Betreuer] Schnittger. "Dissecting the molecular regulation of chromosome axis formation and sister chromatid cohesion during meiosis in Arabidopsis thaliana / Chao Yang ; Betreuer: Arp Schnittger." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1199539074/34.

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14

Mitra, Sayantan. "Arabidopsis Cohesin proteins: WAPL, CTF7 and PHD finger proteins: MMDL1, MMDL2 are essential for proper meiosis, gamete development and plant growth." Miami University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=miami1517605898967702.

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15

Gigant, Emmanuelle. "La cohésion des chromatides sœurs chez Escherichia coli." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00776480.

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Chez les bactéries, la ségrégation du chromosome est initiée durant la phase de réplication. Des expériences de time lapse, utilisées pour observer que la dynamique des loci frères durant le cycle cellulaire, montrent que, chez Escherichia coli, les régions sœurs restent colocalisées pour une période significative dans les régions des macrodomaines du chromosome et pour une courte période dans les régions non-structurées. Nous nous sommes posés la question suivante: est ce que l'étape de colocalisation révèle une réelle cohésion entre les chromatides sœurs ? Pour y répondre, nous avons dévelop

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16

Pritchard, Emily Helen. "Chromatin compaction in Cornelia de Lange syndrome." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5702.

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Cornelia de Lange Syndrome (CdLS) is a multisystem genetic disorder caused by mutations in the cohesin complex. It is believed that cohesin is able to regulate gene expression with CTCF by holding chromatin in topological complexes, such as active chromatin hubs, and that CdLS is caused by loss of these complexes causing aberrant gene expression. In order to determine if loss of these complexes in CdLS resulted in a general change in the compaction of chromatin, I undertook a series of analyses of the nucleus in CdLS patient lymphoblastoid cell lines (LCLs), compared to wildtype, and later in

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17

Delamarre, Axel. "Etude des rôles et du mécanisme de chargement des complexes SMC dans la réponse au stress réplicatif chez S.cerevisiae." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT040/document.

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Les trois complexes SMC Cohésine, Condensine et SMC5/6 sont principalement étudiés pour leurs rôles mitotiques, cependant tous trois sont localisés à proximité des fourches de réplication en condition de stress réplicatif. Au cours de cette thèse, nous nous sommes particulièrement intéressés aux complexes Cohésine et Condensine. Dans une première partie, nous décrivons un nouveau rôle des condensines dans la progression des fourches de réplication en condition de stress réplicatif à l’hydroxyurée (HU) et au Méthyl-Méthane-Sulfonate (MMS). Nos données montrent que dans ces conditions, les conde

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18

Hanssen, Lars. "The role of elements binding CTCF and cohesin in directing tissue-specific enhancer activity." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:eb0f05e4-9563-4fd1-9814-841f1f2cb136.

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Distal enhancer elements regulate the tissue-specific expression of their target genes via the establishment of physical interactions with the gene promoter. In mice, a cluster of five enhancers, jointly classified as a super-enhancer, specifically upregulate α-globin gene expression during erythroid differentiation. Aside from the Nprl3 gene, whose promoter is located inside this enhancer region, expression-levels of other genes within a short distance (&lt,50kb) of the enhancer region are not affected by the activation of the enhancer in erythroid cells, despite being located within th

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19

Bhardwaj, Shweta. "Interplay between chromatin conformation and transcription in eukaryotes." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:7395c490-a296-48e8-b8ca-afd785d516b0.

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The three-dimensional organization of the genome is important for various processes such as transcription, replication, and repair. Several studies have shown that the genome is organized into long-range and short-range chromatin loops. Gene loops represent a short-range chromatin loop, synonymous with the juxtaposition of promoter and terminator regions of a gene. In Chapter III, I investigate the mechanism of gene-loop formation in a constitutively expressed gene, mouse serum albumin (Alb). The Alb locus appears to exist in a clover-leaf structure, with the promoter in close physical proximi

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20

Xu, Weizhen. "The cohesin protein NIPBL recruits histone deacetylases to mediate local chromatin modifications." Lübeck Zentrale Hochschulbibliothek Lübeck, 2010. http://d-nb.info/99943571X/34.

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21

Ochi, Yotaro. "Combined Cohesin-Runx1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes." Kyoto University, 2020. http://hdl.handle.net/2433/258999.

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22

Lebraud, Emilie. "Rôle du médiateur et des cohésines dans la réparation des dommages oxydatifs de l'ADN." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS407/document.

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Les composants cellulaires sont constamment exposés à un stress oxydatif, lié à l’environnement et au métabolisme cellulaire. Les espèces réactives de l’oxygène produites par ce stress induisent de nombreuses lésions dans l’ADN, telles que l’oxydation des bases, la formation de sites abasiques ou la cassure de brins d’ADN. Ces dommages sont corrigés par un panel de systèmes de réparation, qui jouent un rôle critique dans la survie cellulaire et dans la prévention de pathologies telles que les maladies neurodégénératives ou le cancer. La modification de bases est le type de dommage le plus abon

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23

Xu, Weizhen [Verfasser]. "The cohesin protein NIPBL recruits histone deacetylases to mediate local chromatin modifications / Weizhen Xu." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2010. http://d-nb.info/99943571X/34.

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24

Bhatti, Saeeda. "Analysis of the S. pombe sister chromatid cohesin subunit in response to DNA damage agents during mitosis." Thesis, Connect to e-thesis record to view abstract. Move to record for print version, 2008. http://theses.gla.ac.uk/292/.

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Thesis (Ph.D.) - University of Glasgow, 2008.<br>Ph.D. thesis submitted to the Division of Biochemistry and Molecular Biology, Biomedical and Life Sciences (IBLS), University of Glasgow, 2008. Includes bibliographical references. Print version also available.

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Jahnke, Philipp [Verfasser], and Frank [Akademischer Betreuer] Kaiser. "Funktionelle Interaktion des "Cohesin-loading" Proteins NIPBL mit chromatin-assoziierten Faktoren / Philipp Jahnke ; Akademischer Betreuer: Frank Kaiser." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2020. http://d-nb.info/1207348082/34.

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26

Laugsch, Magdalena, Jochen Seebach, Hans Schnittler, and Rolf Jessberger. "Imbalance of SMC1 and SMC3 Cohesins Causes Specific and Distinct Effects." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-127228.

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SMC1 and SMC3 form a high-affinity heterodimer, which provides an open backbone of the cohesin ring, to be closed by a kleisin protein. RNAi mediated knock-down of either one heterodimer partner, SMC1 or SMC3, is expected to cause very similar if not identical phenotypes. However, we observed highly distinct, protein-specific phenotypes. Upon knock-down of human SMC1, much of SMC3 remains stable, accumulates in the cytoplasm and does not associate with other cohesin proteins. Most of the excess nuclear SMC3 is highly mobile and not or only weakly chromosome-associated. In contrast, human SMC3

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27

Eguienta, Karen. "Caractérisation chez schizosaccharomyces pombe du rôle d’un complexe sérine/thréonine phosphatase de type 4 dans la régulation de la cohésion des chromatides soeurs." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0247/document.

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La cohésion des chromatides sœurs est assurée par un complexe protéique en forme d’anneau assurant leur capture topologique. Ce complexe est constitué par des protéines conservées de la levure à l’Homme regroupées sous le terme « cohésine » : Smc1, Smc3 et la phosphoprotéine Scc1 fermant l’anneau (respectivement Psm1, Psm3 et Rad21 chez Schizosaccharomyces pombe). Les protéines régulatrices Rad61-Wapl, Pds5 et Scc3 (Wpl1,Pds5 et Psc3 respectivement chez S. pombe) interagissent avec l’anneau via Scc1. Il a été proposé que la capture de l’ADN par les cohésines nécessite l’ouverture transitoire d

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28

Laugsch, Magdalena, Jochen Seebach, Hans Schnittler, and Rolf Jessberger. "Imbalance of SMC1 and SMC3 Cohesins Causes Specific and Distinct Effects." Public Library of Science, 2013. https://tud.qucosa.de/id/qucosa%3A27288.

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SMC1 and SMC3 form a high-affinity heterodimer, which provides an open backbone of the cohesin ring, to be closed by a kleisin protein. RNAi mediated knock-down of either one heterodimer partner, SMC1 or SMC3, is expected to cause very similar if not identical phenotypes. However, we observed highly distinct, protein-specific phenotypes. Upon knock-down of human SMC1, much of SMC3 remains stable, accumulates in the cytoplasm and does not associate with other cohesin proteins. Most of the excess nuclear SMC3 is highly mobile and not or only weakly chromosome-associated. In contrast, human SMC3

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29

Sabaté, Thomas. "Modeling, visualizing and quantifying chromatin loop extrusion dynamics in living human cells." Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS304.

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L’étude de l’organisation 3D du génome a révélé l’existence de boucles de chromatine et des Topologically Associating Domains (TADs) de l’ordre de plusieurs centaines de kilobases, créés par l’anneau de cohésine par le processus d’extrusion de boucle d’ADN. Cependant, ces structures ont été caractérisées presque exclusivement par des techniques de génomique et d’imagerie de cellules fixées, leur dynamique temporelle reste donc peu comprise. Par exemple, la durée des contacts créés par extrusion de boucles n’est pas définie et des paramètres majeurs de ce processus comme la durée de vie des con

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30

Camus, Adrien. "Étude épistatique de RecN, et des liens entre la cohésion des chromatides sœurs et de la réparation de l’ADN chez Escherichia coli." Electronic Thesis or Diss., Université Paris sciences et lettres, 2022. http://www.theses.fr/2022UPSLE029.

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Afin de préserver leur niche de vie, les bactéries produisent et sécrètent des antibiotiques avec des propriétés génotoxiques. Divers processus moléculaires maintiennent l’intégrité génomique de tous les organismes vivants. Ces évènements sont primordiaux car la structure de l’ADN est endommagée en permanence par le métabolisme cellulaire (tel que le stress oxydatif ou lors de sa réplication), ou d’autres agents de l’environnement. Les antibiotiques sont utilisés pour des applications cliniques afin de traiter les infections ou le cancer. Dans le travail ici présenté, nous analysons la réponse

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31

Abramo, Kristin N. "Building the Interphase Nucleus: A study on the kinetics of 3D chromosome formation, temporal relation to active transcription, and the role of nuclear RNAs." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1099.

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Following the discovery of the one-dimensional sequence of human DNA, much focus has been directed on microscopy and molecular techniques to learn about the spatial organization of chromatin in a 3D cell. The development of these powerful tools has enabled high-resolution, genome-wide analysis of chromosome structure under many different conditions. In this thesis, I focus on how the organization of interphase chromatin is established and maintained following mitosis. Mitotic chromosomes are folded into helical loop arrays creating short and condensed chromosomes, while interphase chromosomes

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32

Santos, Mariana Batista. "Cohesion decay: quantitative analysis of partial sister chromatid cohesion." Master's thesis, 2014. http://hdl.handle.net/10362/13875.

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Cell division is a highly dynamic process where sister chromatids remain associated with each other from the moment of DNA replication until the later stages of mitosis, giving rise to two daughter cells with equal genomes. The “molecular glue” that links sister DNA molecules is called cohesin, a tripartite ring-like protein complex composed of two Structural Maintenance of Chromosome proteins (Smc1 and Smc3) bridged by a kleisin subunit Rad21/Scc1, that together prevent precocious sister chromatid separation. Accumulating evidence has suggested that cohesion decay may be the cause of segrega

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33

Lam, Wendy W. S. "Keeping sisters together : cohesin and Ycs4 define distinct mechanisms for sister chromatid cohesion." 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=362417&T=F.

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34

Xu, Hong. "Global view and genetic dissection of genes in sister chromatid cohesion." 2007. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=742451&T=F.

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35

Antoniacci, Lisa Morgan. "Characterization of a novel protein found to interact with the Saccharomyces cerevisiae Cohesion Establishment Factor Ctf7p /." Diss., 2005. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3167045.

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36

Wang, Zhenghe. "Pol [kappa] : a novel DNA polymerase required for sister chromatid cohesion and DNA repair /." 2001. http://wwwlib.umi.com/dissertations/fullcit/9987208.

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37

Ma, Jian. "Studies on the mechanisms of homolog pairing and sister chromatid cohesion during Drosophila male meiosis." 2007. http://etd.utk.edu/2007/MaJian.pdf.

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38

Keall, Rebecca M. "Molecular and genetic analysis of Drosophila Rad21: a gene and protein involved in sister chromatid cohesion." Thesis, 2005. https://researchonline.jcu.edu.au/2088/1/01front.pdf.

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The accurate and efficient dissemination of replicated chromosomes into daughter cells is fundamental to all aspects of biology. Chromosomal missegregation can lead to aneuploid chromosome configurations which are a hallmark of cancer cells and also a leading cause of birth defects and infertility in humans. Given that chromosome missegregation can result in such disastrous consequences, cells have evolved mechanisms to ensure the faithful segregation of chromosomes, one of which is sister-chromatid cohesion which is mediated by the cohesin complex. Cohesin is a multi-protein complex

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39

Seepany, Harshika. "Chromatin Reassembly following a DNA Double-Strand Break Repair: The Ctf18-complex and Ctf4 work in concert with H3K56 Acetylation." Thesis, 2011. http://hdl.handle.net/1807/29616.

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The budding yeast, Saccharomyces cerevisiae, serves as an excellent model for identifying fundamental mechanisms of DNA repair. A Local Coherence Detection (LCD) algorithm that uses biclustering to assign genes to multiple functional sub-groups was applied on the chromosome E-MAP containing genetic interactions among genes involved in nuclear processes. Using this method, we found that Asf1 and Rtt109, genes that are together required for histone H3K56 acetylation, cluster together with Ctf4, Ctf18, Ctf8 and Dcc1, genes important for efficient sister chromatid cohesion. It is known that H3K56

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Kothiwal, Deepash. "A role for the cohesin complex in subtelomeric gene silencing in Saccharomyces cerevisiae." Thesis, 2018. https://etd.iisc.ac.in/handle/2005/5335.

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Chromatin is a dynamic structure which reorganizes to support numerous chromosomal processes. Various histone and non-histone proteins are involved in chromatin organization. One such group of non-histone proteins, known as SMC (Structural Maintenance of Chromosomes) proteins, plays a pivotal role in chromosome organization. SMC proteins are highly conserved in all three domains of life. The Saccharomyces cerevisiae genome codes for at least six SMC proteins, which along with non-SMC partners form three different complexes named as cohesin, condensin and the SMC5/6 complex. Cohesin is an evolu

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