Relevant bibliographies by topics / Chronic hyperglycemia

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Chronic hyperglycemia'

Author: Grafiati
Published: 28 May 2022
Last updated: 31 July 2025

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Journal articles on the topic "Chronic hyperglycemia"

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Strycharz, Justyna, Ewa Świderska, Adam Wróblewski, et al. "Hyperglycemia Affects miRNAs Expression Pattern during Adipogenesis of Human Visceral Adipocytes—Is Memorization Involved?" Nutrients 10, no. 11 (2018): 1774. http://dx.doi.org/10.3390/nu10111774.

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microRNAs are increasingly analyzed in adipogenesis, whose deregulation, especially visceral, contributes to the development of diabetes. Hyperglycemia is known to affect cells while occurring acutely and chronically. Therefore, we aimed to evaluate the effect of hyperglycemia on human visceral pre/adipocytes from the perspective of microRNAs. The relative expression of 78 microRNAs was determined by TaqMan Low Density Arrays at three stages of HPA-v adipogenesis conducted under normoglycemia, chronic, and intermittent hyperglycemia (30 mM). Hierarchical clustering/Pearson correlation revealed
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Bishara, Amy, Stephanie V. Phan, Henry N. Young, and T. Vivian Liao. "Glucose Disturbances and Atypical Antipsychotic Use in the Intensive Care Unit." Journal of Pharmacy Practice 29, no. 6 (2016): 534–38. http://dx.doi.org/10.1177/0897190015579452.

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Purpose: Chronic use of atypical antipsychotics may lead to metabolic abnormalities including hyperglycemia. Although evidence supports acute hyperglycemic episodes associated with atypical antipsychotic use, the acute use of atypical antipsychotics in the intensive care unit (ICU) setting has not been studied. The purpose of this study is to evaluate the occurrence of hyperglycemia in ICU patients receiving newly prescribed atypical antipsychotic. Summary: Of the 273 patient charts reviewed, 50 patients were included in this study. Approximately 45% of patients experienced at least 1 hypergly
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Luitse, Merel JA, Birgitta K. Velthuis, L. Jaap Kappelle, Yolanda van der Graaf, and Geert Jan Biessels. "Chronic hyperglycemia is related to poor functional outcome after acute ischemic stroke." International Journal of Stroke 12, no. 2 (2016): 180–86. http://dx.doi.org/10.1177/1747493016676619.

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Background Acute hyperglycemia is associated with poor functional outcome after ischemic stroke, but the association between chronic antecedent hyperglycemia and outcome is unclear. Aim We assessed the association between chronic hyperglycemia, measured by hemoglobin A1c, and functional outcome in patients with acute ischemic stroke. Methods We included 812 patients with acute ischemic stroke (mean age 66 ± 14 years; 61.5% male). Patients were categorized per hemoglobin A1c level: no (<39 mmol/mol), moderate (39–42 mmol/mol), or severe chronic hyperglycemia (>42 mmol/mol). Poor functiona
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Lund, Jenny, D. Margriet Ouwens, Marianne Wettergreen, Siril S. Bakke, G. Hege Thoresen, and Vigdis Aas. "Increased Glycolysis and Higher Lactate Production in Hyperglycemic Myotubes." Cells 8, no. 9 (2019): 1101. http://dx.doi.org/10.3390/cells8091101.

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Previous studies have shown that chronic hyperglycemia impairs glucose and fatty acid oxidation in cultured human myotubes. To further study the hyperglycemia-induced suppression of oxidation, lactate oxidation, mitochondrial function and glycolytic rate were evaluated. Further, we examined the intracellular content of reactive oxygen species (ROS), production of lactate and conducted pathway-ANOVA analysis on microarray data. In addition, the roles of the pentose phosphate pathway (PPP) and the hexosamine pathway were evaluated. Lactic acid oxidation was suppressed in hyperglycemic versus nor
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Świderska, Ewa, Marta Podolska, Justyna Strycharz та ін. "Hyperglycemia Changes Expression of Key Adipogenesis Markers (C/EBPα and PPARᵞ)and Morphology of Differentiating Human Visceral Adipocytes". Nutrients 11, № 8 (2019): 1835. http://dx.doi.org/10.3390/nu11081835.

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Disturbances in adipose tissue significantly contribute to the development of metabolic disorders, which are connected with hyperglycemia (HG) and underlain by epigenetics-based mechanisms. Therefore, we aimed to evaluate the effect of hyperglycemia on proliferating, differentiating and maturating human visceral pre/adipocytes (HPA-v). Three stages of cell culture were conducted under constant or variable glycemic conditions. Adipogenesis progress was assessed using BODIPY 505/515 staining. Lipid content typical for normal and hyperglycemic conditions of adipocytes was analyzed using Raman spe
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Frost, Mackenzie S., Aqib H. Zehri, Sean W. Limesand, William W. Hay та Paul J. Rozance. "Differential Effects of Chronic Pulsatile versus Chronic Constant Maternal Hyperglycemia on Fetal Pancreaticβ-Cells". Journal of Pregnancy 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/812094.

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Constant maternal hyperglycemia limits, while pulsatile maternal hyperglycemia may enhance, fetal glucose-stimulated insulin secretion (GSIS) in sheep. However, the impact of such different patterns of hyperglycemia on the development of the fetalβ-cell is unknown. We measured the impact of one week of chronic constant hyperglycemia (CHG,n=6) versus pulsatile hyperglycemia (PHG,n=5) versus controls (n=7) on the percentage of the fetal pancreas staining for insulin (β-cell area), mitotic and apoptotic indices and size of fetalβ-cells, and fetal insulin secretion in sheep. Baseline insulin conce
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de Mello-Sampayo, Cristina, Alaíde Alves Agripino, Duarte Stilwell, et al. "Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures." International Journal of Endocrinology 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/4603247.

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There is controversy concerning the diabetes impact on bone quality, notorious in type 2 diabetic postmenopausal women. One pointed cause might be uncontrolled glycemia. In this study, the effect of chronic hyperglycemia in bone turnover, morphology, and biomechanics was evaluated in female Wistar rats in the presence/absence of estrogens (ovariectomy). Animals (n=28) were divided into sham, ovariectomized (OVX), hyperglycemic (streptozotocin 40 mg/kg, single-dose i.p.-STZ), and hyperglycemic-ovariectomized (STZ + OVX) animals. Blood biomarkers were estimated 60 days postovariectomy. Body weig
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Khan, Shahzad, and Mohammad A. Kamal. "Wogonin Alleviates Hyperglycemia Through Increased Glucose Entry into Cells Via AKT/GLUT4 Pathway." Current Pharmaceutical Design 25, no. 23 (2019): 2602–6. http://dx.doi.org/10.2174/1381612825666190722115410.

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: Insulin resistance and type 2 Diabetes mellitus resulting in chronic hyperglycemia is a major health problem in the modern world. Many drugs have been tested to control hyperglycemia which is believed to be the main factor behind many of the diabetes-related late-term complications. Wogonin is a famous herbal medicine which has been shown to be effective in controlling diabetes and its complications. In our previous work, we showed that wogonin is beneficial in many ways in controlling diabetic cardiomyopathy. In this review, we mainly explained wogonin anti-hyperglycemic property through AK
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Marcovecchio, M. Loredana. "Complications of Acute and Chronic Hyperglycemia." US Endocrinology 13, no. 01 (2017): 17. http://dx.doi.org/10.17925/use.2017.13.01.17.

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Hyperglycemia is due to a dysregulation in the complex mechanisms implicated in glucose homeostasis. Chronic hyperglycemia, as measured by hemoglobin A1c (HbA1c), is a key risk factor for the development of microvascular and macrovascular complications, which in turn negatively influence the prognosis of patients with diabetes. Several studies have shown that acute hyperglycemia can add to the effect of chronic hyperglycemia in inducing tissue damage. Acute hyperglycemia can manifest as high fasting plasma glucose (FPG) or high postprandial plasma glucose (PPG) and can activate the same metabo
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Clark, C. M. "The Burden of Chronic Hyperglycemia." Diabetes Care 21, Supplement_3 (1998): C32—c34. http://dx.doi.org/10.2337/diacare.21.3.c32.

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Dissertations / Theses on the topic "Chronic hyperglycemia"

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Alaei, Shahmiri Fariba. "The potential association between thiamin, hyperglycemia and chronic diseases." Thesis, Curtin University, 2012. http://hdl.handle.net/20.500.11937/1209.

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Chronic diseases, such as cardiovascular disease and diabetes, are the leading causes of morbidity and mortality worldwide. Recent studies have shown that in addition to diabetes mellitus, non-diabetic degrees of fasting and postprandial hyperglycemia are also directly linked to accelerated risks of cardiovascular diseases. Thiamin is a water soluble vitamin playing a key regulatory role as a co-enzyme in metabolic pathways implicated in the glucose metabolism. There is some evidence that diabetic patients are prone to thiamin deficiency possibly because of an increased excretion of thiamin in
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You, Dan. "Effects of chronic hyperglycemia on gene expression in streptozotocin-induced diabetic rats." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/mq22693.pdf.

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Zehri, Aqib Hyder. "Differential Effects of Pulsatile vs. Chronic Hyperglycemia on Fetal Pancreatic Beta Cell Population." Thesis, The University of Arizona, 2011. http://hdl.handle.net/10150/145129.

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Villanueva, Melanie. "Glyoxalase 1 Attenuates the Effects of Chronic Hyperglycemia on Explant-Derived Cardiac Stem Cells." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36901.

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Given that chronic hyperglycemia generates toxic methylglyoxal, the detoxifying effect of glyoxalase-1 (Glo1) on chronic hyperglycemia induced explant-derived cardiac stem cell (EDC) dysfunction was investigated. Wildtype (WT) and Glo1 over-expressing (Glo1TG) mice with or without streptozotocin treatment were studied. Hyperglycemia reduced overall culture yields while increasing the reactive dicarbonyl content within WT mice. These intrinsic cell changes reduced the angiogenic potential and nanoparticle production by hyperglycemic EDCs while promoting cell senescence. Compared to transplant o
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Nyambuya, Tawanda Maurice. "Markers of chronic immune activation and T-cell function in hyperglycaemia." Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2597.

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Thesis (MTech (Biomedical Sciences))--Cape Peninsula University of Technology, 2017.<br>Type 2 diabetes mellitus (T2DM) is a chronic inflammatory condition characterised by hyperglycaemia; continuous activation of T-lymphocytes and immune dysregulation. Although the exact mechanisms of these phenomena are not fully understood, there is strong evidence suggesting the involvement of T-cells in the chronic inflammatory environment which could predispose diabetics to infections and thrombotic events. The effect of hyperglycaemia on cells of the innate immune system in T2DM has been well described
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Hara, Tadashi. "Significance of chronic marked hyperglycemia on FDG-PET: is it really problematic for clinical oncologic imaging?" Kyoto University, 2010. http://hdl.handle.net/2433/120924.

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COSENTINO, NICOLA. "EFFECTS OF STRESS HYPERGLYCEMIA ACCORDING TO DIABETICSTATUS IN PATIENTS WITH ST-ELEVATION MYOCARDIALINFARCTION AND ITS RELATIONSHIP WITH CARDIAC CELL INJURYAND MITOCHONDRIAL DAMAGE: A TRANSLATIONAL APPROACH." Doctoral thesis, Università degli Studi di Milano, 2023. https://hdl.handle.net/2434/946992.

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Background: Acute hyperglycemia (AH) is common in ST-elevation myocardial infarction (STEMI) and predicts outcomes. AH is a more powerful prognostic predictor in patients without diabetes mellitus (DM) than with DM, emphasizing the role of an acute glucose rise compared to chronic elevations. Moreover, AH may exacerbate, thorough mitochondrial dysfunction, infarct size (IS). We investigated the association between AH and chronic glycemia, considered separately or in combination, with mitochondrial injury and myocardial IS in STEMI patients with or without DM. Methods: We measure
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Мелеховець, Оксана Костянтинівна, Оксана Константиновна Мелеховец, Oksana Kostiantynivna Melekhovets та ін. "Індукція хронічної гіперглікемії та оцінка життєздатності щурів різних вікових груп". Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/44914.

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Враховуючі геометричну прогресію захворюваності на цукровий діабет у всьому світі, створення експериментальних моделей гіперглікемічних станів набуває все більшого значення для вивчення структурно-функціональних змін на клітинному, органному та системному рівнях. Чисельні роботи останніх років наполягають на необхідності заходів первинної профілактики діабету та ранньої корекції будь-яких порушень вуглеводного метаболізму.
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Santos, Fabiana Almeida dos. "Adutos de DNA relacionados ao estresse oxidativo e glicação avançada em ratos diabéticos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-17122014-144700/.

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O diabetes mellitus é considerado um dos problemas de saúde globalmente mais desafiadores do século 21. De acordo com as estimativas recentes do International Diabetes Federation - IDF, cerca de 382 milhões de pessoas são diabéticas e esse número tende a aumentar para além de 592 milhões em menos de 25 anos. Para melhor compreensão do Diabetes mellitus e suas complicações torna-se necessário buscar novos marcadores para a doença. O DM promove estresse oxidativo, inflamação e a formação de produtos avançados de glicação não enzimática (AGES), o que leva a dano tecidual no paciente diabético. Ma
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Дудченко, Євгеній Сергійович, Евгений Сергеевич Дудченко та Yevhenii Serhiiovych Dudchenko. "Морфофункціональні особливості репаративного остеогенеза за умов хронічної гіперглікемії (анатомо-експериментальне дослідження)". Thesis, Сумський державний університет, 2021. https://essuir.sumdu.edu.ua/handle/123456789/83984.

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Дисертаційна робота присвячена визначенню морфологічних особливостей репаративного остеогенезу у щурів із хронічною гіперглікемією, а також з’ясуванню можливості застосування збагаченої тромбоцитами плазми крові для корекції процесу репаративної регенерації довгої кістки щурів за умов впливу хронічної гіперглікемії. Експериментальне дослідження було проведено на 380 білих лабораторних щурах – самцях зрілого віку, які були розподілені на чотири групи: I група – контрольна (120 щурів) із модельованим дірчастим дефектом діафіза великогомілкової кістки; II група – 120 щурів із хронічною гіперглік
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Books on the topic "Chronic hyperglycemia"

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Westman, Eric C., Emily Maguire, and William S. Yancy. Ketogenic Diets as Highly Effective Treatments for Diabetes Mellitus and Obesity. Edited by Dominic P. D’Agostino. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0037.

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Obesity and type 2 diabetes mellitus (T2DM) have reached epidemic proportions worldwide. While characterized by chronic hyperglycemia, the underlying cause of T2DM is insulin resistance—most often related to an increase in abdominal adiposity caused by obesity. The goal of treatment of T2DM is to put the disease into remission by targeting the underlying insulin resistance. The observation that dietary carbohydrate is the major factor to cause glycosuria and hyperglycemia, has been known since the early days of modern medicine. As a result, low-carbohydrate, ketogenic diets were employed to tr
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Soler, Ximena, and Lori A. Aronson. Diabetic Ketoacidosis During Appendicitis with Perforation. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199764495.003.0047.

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Type 1 diabetes mellitus (DM) is a chronic disease of carbohydrate, fat, and protein metabolism caused by a functional lack of insulin. Diabetic ketoacidosis (DKA) involves a combination of hyperglycemia, acidosis and ketosis, and is more often associated with type 1 DM. A child in DKA who presents for emergency surgery may be critically ill and requires expert management of his or her metabolic state to ensure a safe outcome.
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Treutel, Adonis. TERBlNAFlNE: A Recommended Medicine for the Treatment of Nail Fungus, Candida, Chronic Hyperglycemia, Dandruff, Itchy Scalp, Fungal Infections, Ringworm, Athlete's Foot and Jock Itch. Independently Published, 2019.

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Book chapters on the topic "Chronic hyperglycemia"

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Fried, Robert, and Richard M. Carlton. "Chronic Hyperglycemia—A Primer." In Type 2 Diabetes. CRC Press, 2018. http://dx.doi.org/10.1201/9780429507250-1.

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Fried, Robert, and Richard M. Carlton. "Chronic Hyperglycemia Impairs Vision, Hearing, and Sensory Function." In Type 2 Diabetes. CRC Press, 2018. http://dx.doi.org/10.1201/9780429507250-5.

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Fried, Robert, and Richard M. Carlton. "General Nutritional Considerations for Chronic Hyperglycemia—Type 2 Diabetes." In Type 2 Diabetes. CRC Press, 2018. http://dx.doi.org/10.1201/9780429507250-8.

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Fried, Robert, and Richard M. Carlton. "Selected Functional Foods That Combat the Effects of Hyperglycemia and Chronic Inflammation." In Type 2 Diabetes. CRC Press, 2018. http://dx.doi.org/10.1201/9780429507250-11.

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Hisar, Kemal Macit. "A Global Public Health Issue: Diabetes Mellitus." In Current Perspective on Diabetes Mellitus in Clinical Sciences. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359111.1.

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Diabetes Mellitus is a significant global health concern characterized by chronic hyperglycemia resulting from insulin secretion or action defects. Its prevalence escalates due to aging populations, urbanization, sedentary lifestyles, and poor diets. The disease manifests primarily as Type 1 (autoimmune destruction of pancreatic beta cells) and Type 2 (insulin resistance with relative deficiency). Complications include cardiovascular diseases and microvascular issues like retinopathy and neuropathy. Management involves lifestyle changes, medications, insulin therapy, and regular monitoring. Ad
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Hossain, K., V. Mondal, Z. Hosen, et al. "Chronic arsenic exposure dose-dependently increases the risk of hyperglycemia through skeletal muscle mass reduction." In Arsenic in the Environment: Bridging Science to Practice for Sustainable Development As2021. CRC Press, 2024. http://dx.doi.org/10.1201/9781003317395-96.

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Ozpamuk Karadeniz, Fatma. "Cardiac Macrovascular Complications of Diabetes." In Current Perspective on Diabetes Mellitus in Clinical Sciences. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359111.9.

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Cardiac macrovascular complications are a significant concern in individuals with diabetes mellitus, stemming from the disease’s profound impact on cardiovascular health. Diabetes accelerates the development of atherosclerosis, characterized by the buildup of plaque within arterial walls, which can lead to coronary artery disease (CAD), myocardial infarction (heart attack), and stroke. The underlying mechanisms involve chronic hyperglycemia, which promotes oxidative stress, inflammation, and endothelial dysfunction, contributing to the initiation and progression of vascular damage. Additionall
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Uguz, A. Cihangir. "The Role of Ion Channels in Diabetes Mellitus." In Current Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359104.11.

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The role of ion channels in diabetes mellitus encompasses their critical involvement in regulating cellular functions central to glucose metabolism and insulin secretion. Ion channels, such as potassium (K+) channels and calcium (Ca2+) channels, play pivotal roles in pancreatic beta cells where they govern insulin secretion in response to changes in blood glucose levels. ATP-sensitive K+ channels (KATP channels) mediate glucose-stimulated insulin secretion by modulating cell membrane potential and calcium influx, essential for triggering insulin release. Dysfunction or dysregulation of these i
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Dasdelen, Dervis. "Apoptosis Induced by Diabetes." In Current Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359104.12.

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Apoptosis induced by diabetes refers to programmed cell death that occurs in various tissues and organs as a consequence of chronic hyperglycemia and associated metabolic disturbances. In diabetes mellitus, prolonged exposure to elevated glucose levels triggers multiple pathways leading to cellular stress, oxidative damage, and ultimately, apoptosis. This phenomenon is particularly notable in pancreatic beta cells, where apoptosis contributes to the progressive decline in insulin secretion and the development of type 1 and type 2 diabetes. In addition to pancreatic beta cells, apoptosis is obs
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Ragbetli, Murat Cetin, and Aysenur Kaya. "Histopathological Changes in Diabetic Pancreas." In Current Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359104.3.

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Histopathological changes in the diabetic pancreas are characterized by several key alterations that impact its structure and function. In type 1 diabetes mellitus (T1DM), autoimmune destruction of insulin-producing beta cells within the pancreatic islets results in their selective loss, termed insulitis. This process involves infiltration of immune cells such as T lymphocytes and macrophages into the islets, leading to progressive beta cell destruction and ultimately insulin deficiency. In contrast, type 2 diabetes mellitus (T2DM) is associated with insulin resistance and eventual beta cell d
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Conference papers on the topic "Chronic hyperglycemia"

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Hendawi, Hadeel Khalil, Dina Nehad Awartani, Aya Ghoul, and Isra Marei. "Effect of Hyperglycemia on Epcs Function and Regenerative Ability." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0216.

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Diabetes induced hyperglycemia increases the risk of cardiovascular complications as it impacts vascular endothelial cells causing vascular dysfunction. Endothelial progenitor cells (EPCs) have been suggested to participate in the repair of vascular endothelial cells once they are impacted by hyperglycemia in diabetic patients. This research aims to test the EPC subtype blood outgrowth endothelial cells (BOECs) and their ability to survive and function under chronic hyperglycemic conditions. For that, we studied BOECs viability, response to shear stress, angiogenesis ability, and barrier funct
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Tavares, Wagner, Rosângela Lima da Silva, Francivaldo José da Conceição Mendes, et al. "Effects of physiotherapy programs in the treatment and control of diabetes mellitus: A review." In V Seven International Multidisciplinary Congress. Seven Congress, 2024. http://dx.doi.org/10.56238/sevenvmulti2024-142.

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Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, resulting from a deficiency in the production or action of the hormone insulin. This hormone is produced by pancreatic beta cells, and is responsible for regulating glucose metabolism, promoting its uptake by tissues. Its characteristics are: chronic hyperglycemia, which is generally accompanied by dyslipidemia; arterial hypertension; and endothelial dysfunction.
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Elshiekh, Duaa Ibnomer, Hadeel Hendawi, Aya Goul, et al. "Effect of Hyperglycemia on eNOS function in EPCs." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0215.

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Type 2 diabetes mullites (T2DM) results in different cardiovascular complications. The main cause of these complications is endothelial dysfunction, which affects the endothelium physiologically and pathologically. The chronic hyperglycemia introduced by T2DM impacts the pivotal enzyme endothelial nitric oxide synthase (eNOS) in terms of phosphorylation and dimerization, which initiates oxidative stress and reduces the bioavailability of the vasodilator nitric oxide. To overcome endothelial dysfunction, endothelial progenitor cells (EPCs) contribute to vascular repair due to their regenerative
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Diniz, Clebiana Alves e. silva, Poliana Silva de Brito, Tainan de Andrade Rocha, Suzana Maria de Oliveira Costa Meneses, and Julia Maria Pacheco Lins Magalhães. "Elderly people with diabetes: an analysis of the factors that are associated with lower limb amputation." In II INTERNATIONAL SEVEN MULTIDISCIPLINARY CONGRESS. Seven Congress, 2023. http://dx.doi.org/10.56238/homeinternationalanais-028.

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Abstract Population aging has been occurring extremely rapidlyin developing countries, implying a higher prevalence of chronic-degenerative diseases (NCDs,s). Among these, diabetes mellitus stands out, a syndrome characterized by a chronic state of hyperglycemia and disorders in the metabolism of carbohydrates, lipids and proteins, associated with absolute or relative insulin deficiency and/or its action in the body.
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Berilli, Ana Luiza de Jesus, and Maria Luiza Ferreira Stringhini. "Type 2 diabetes mellitus and depression." In V Seven International Multidisciplinary Congress. Seven Congress, 2024. http://dx.doi.org/10.56238/sevenvmulti2024-072.

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Type 2 diabetes mellitus (DM2) is a chronic non-communicable disease characterized by persistent hyperglycemia resulting from a deficiency in the synthesis and/or secretion of insulin by pancreatic b-cells, associated with other factors such as insulin resistance in peripheral tissues, hyperglucagonemia , increased hepatic gluconeogenesis, among others (American Diabetes Association, 2023; WHO, 2019). According to the International Diabetes Federation 2021, approximately 8.8% of the world's adult population has diabetes, of which 79% live in developing countries. Following this projection, it
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Euceda, G. J., G. Celenza, S. Ventrone, M. Kokoszynska, J. J. Bivona, and B. T. Suratt. "Markers of Chronic Hyperglycemia Correlate with Attenuated Acute Lung Inflammatory Response in Murine Models of Diabetes." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6533.

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Davydova, E. V., E. V. Nuzhdina, and V. S. Oleinik. "FEATURES OF HEART RATE VARIABILITY IN DIABETES MELLITUS IN PATIENTS TRAINED IN THE CONDITIONS OF INDUSTRIAL VIBRATION." In The 17th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2023). FSBSI «IRIOH», 2023. http://dx.doi.org/10.31089/978-5-6042929-1-4-2023-1-156-160.

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Industrial vibration is one of the most common factors of the labor process. In recent years, similar to the structure of morbidity in the Russian Federation as a whole, an increase in the incidence of type 2 diabetes mellitus has been noted among workers of harmful industries. In this connection, the issues of actual admission to work in contact with the production vibration in the case of diagnosed diabetes mellitus are inevitable. This problem is aggravated by the fact that in chronic hyperglycemia and vibration disease, the pathogenesis processes are unidirectional with respect to changes
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Jakhotia, Sneha, Branislav Nastasijević, Gordana Joksić, Sreenivasa Reddy, and G. Bhanuprakash Reddy. "Gentiana lutea AND DIABETIC COMPLICATIONS." In 8th Workshop Food and Drug Safety and Qualit. Vinča Institute of Nuclear Sciences - National Institute of the Republic of Serbia, 2024. http://dx.doi.org/10.46793/8fdsq.ild1sj.

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Chronic hyperglycemia in diabetes leads to macro and microvascular complications. An increase in the aldose reductase (ALR2) activity, accumulation of sorbitol, accumulation of advanced glycation end-products (AGEs), and inflammation lead to cellular damage, ultimately resulting in complications. ALR2 inhibition has been a consideration to treat/manage diabetic complications, but most of the ALR2 inhibitors are not free of side effects. As a part of our work to find better ALR2 inhibitors, we found that extracts of Gentiana lutea exhibited ALR2 inhibitory potential in vitro. We have also disco
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Fauziah, Nurul, Dini Sri Damayanti, and Ariani Ratri Dewi. "Effect of Sucrose Immersion on Retinal Tissue Damage of Adult Zebrafish." In 8th International Students Science Congress. ULUSLARARASI ÖĞRENCİ DERNEKLERİ FEDERASYONU (UDEF), 2024. https://doi.org/10.52460/issc.2024.005.

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Sucrose is a disaccharide macronutrient consisting of glucose and fructose. Sucrose can directly enter the bloodstream and increase blood glucose levels and increase the risk of type 2 diabetes which is characterized by hyperglycemia. Chronic conditions of hyperglycemia contribute to complications of diabetic retinopathy (DR). ganglion cell death results in the thinning of the Inner Plexiform Layer (IPL) which appears in the early stages of diabetic retinopathy. The research aims to prove the effect of sucrose induction at a dose of 1%, 2% and 4% on retinal damage in adult Danio rerio. The res
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Balaji, Swathi, Sachin S. Vaikunth, Jignesh K. Parvadia, Timothy M. Crombleholme, and Daria A. Narmoneva. "In Situ Tissue Engineering Using Angiogenic Nanoscaffold Enhances Diabetic Wound Healing in db/db Mouse Model." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192198.

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Tissue engineering offers an attractive alternative for treatment of chronic nonhealing diabetic ulcers, which account for more than 27% of the $10.9 billion total diabetic health care costs in the US annually [1]. The harsh environment of a diabetic ulcer is characterized by reduced expression of angiogenic factors, insufficient vascularization, excess protease activity, matrix degradation and hyperglycemia-induced cell apoptosis [2]. A major factor contributing to insufficient neovascularization in diabetic nonhealing wounds may be deficiency in the recruitment of endothelial cells (ECs) and
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