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Dissertations / Theses on the topic 'Cleft palate'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 July 2024

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1

Reiser, Erika. "Cleft Size and Maxillary Arch Dimensions in Unilateral Cleft Lip and Palate and Cleft Palate." Doctoral thesis, Uppsala universitet, Käkkirurgi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160178.

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The wide variation in infant maxillary morphology and cleft size of children with unilateral cleft lip and palate (UCLP) and isolated cleft palate (CP) raise concerns about their possible influences on treatment outcome. The studies in this thesis aimed to investigate the relation between cleft size in infancy and crossbite at 5 years of age (Paper I); the impact of primary surgery on cleft size and maxillary arch dimensions from infancy to 5 years of age (Paper II); associations between cleft size, maxillary arch dimensions and facial growth in both UCLP and CP children (Paper III); and, to evaluate the relation between infant cleft size and nasal airway size and function in adults treated for UCLP (Paper IV). In homogenously treated groups of children with UCLP and CP, dental casts were used to measure cleft size and maxillary arch dimensions from infancy up to 5 years of age, and for crossbite recording at 5 years. Serial lateral cephalometric radiographs taken between 5 and 19 years of age in the same groups were used to study facial growth. Nasal airway size and function were evaluated by acoustic rhinometry, rhinomanometry, peak nasal inspiratory flow and odour test in a group of adults treated for UCLP. The main findings were: crossbite was a frequent malocclusion at 5 years of age in children with UCLP and large cleft widths at the level of the cuspid points in infancy were associated with less anterior and posterior crossbite in this group (Paper I). Cleft widths decreased after lip closure and/or soft palate closure in both UCLP and CP children. Initially, UCLP children had wider maxillary arch dimensions, but after hard palate closure, the transverse growth was reduced, and at 5 years, they had smaller maxillary arch widths than CP children had (Paper II). Maxillary arch depths and cleft widths in infancy were correlated with maxillary protrusion and sagittal jaw relationships in both UCLP and CP children (Paper III), but cleft width in infancy was not correlated with nasal airway size and function in adults treated for UCLP (Paper IV).

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2

Ho, Kwan-wai Annie. "Variability of cleft palate speech." Click to view the E-thesis via HKUTO, 2001. http://sunzi.lib.hku.hk/hkuto/record/B36207883.

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Thesis (B.Sc)--University of Hong Kong, 2001.
"A dissertation submitted in partial fulfilment of the requirements for the Bachelor of Science (Speech and Hearing Sciences), The University of Hong Kong, May 4, 2001." Also available in print.

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3

KLATT, REGAN ELIZABETH MARIE. "HYPERACTIVITY AND INATTENTION IN CHILDREN WITH ISOLATED CLEFT LIP AND PALATE OR ISOLATED CLEFT PALATE." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1027946980.

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4

Ren, Yan-Fang. "Posterior pharyngeal flap for elimination of velopharyngeal incompetence a study of facial growth, tongue positions and the significance of adenoids before and after operation /." Umeå, Sweden : Department of Oral and Maxillofacial Radiology, Umeå University, 1995. http://catalog.hathitrust.org/api/volumes/oclc/35846945.html.

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5

Sanghvi, Sonali. "Treatment profile for cleft lip and palate /." Title page, summary and contents only, 1995. http://web4.library.adelaide.edu.au/theses/09DM/09dms225.pdf.

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6

Kutbi, Hebah Alawi. "THE ROLE OF OBESITY, DIABETES, AND HYPERTENSION IN CLEFT LIP AND CLEFT PALATE BIRTH DEFECTS." DigitalCommons@USU, 2014. https://digitalcommons.usu.edu/etd/3081.

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Orofacial clefts (OFCs) are among the most common structural birth defects and a public health problem. Several studies suggest that maternal obesity pre-existing diabetes mellitus (DM), and the underlying metabolic abnormalities, may be involved in the pathogenesis of cleft lip (CL) and cleft palate (CP) birth defects. Although hypertension and gestational diabetes mellitus (GDM) have been associated in a few studies with congenital birth defects, studies examining the risk associated with OFCs are limited. The overall objective of this dissertation was to examine the association between maternal obesity, DM, GDM, and hypertension and the risk of OFCs in case-control studies. Analyses of data from an international consortium revealed that maternal obesity (pre-pregnancy BMI >30), compared to normal weight (18.525), was associated with an increased risk of cleft palate with or without cleft lip (CP/L) (adjusted odds ratio (aOR) =1.13 [95% confidence intervals (CI) 1.01-1.25]). We also found a marginal association between maternal underweight and CP/L (1.0 [reference]; aOR=1.14 [0.97-1.34]. CL only was not associated with maternal bodyweight. Interestingly, among college-graduates, there was no increased risk of CP, but mothers with less than a completed college education had an increased risk of CP for underweight and obesity. Investigation of the Utah OFC data provided evidence that maternal GDM is significantly associated with isolated (aOR=2.63 [1.30-5.34]) and non-isolated clefts (aOR=2.66 [1.02-6.97]). Maternal hypertension is significantly associated with non-isolated clefts (aOR=6.56 [2.18-19.77]). We found a further elevated risk of OFCs among GDM mothers and those with hypertension who were also obese. The analyses of data from an international consortium revealed significant associations between maternal diabetes and the risk of OFCs. The estimated relative risk of DM for isolated OFCs was 1.33 [1.14-1.54] and was slightly higher for multiple OFCs (aOR=1.86 [1.44-2.40]). Diabetic mothers with abnormal body-mass-index had an increased risk for having inborn with OFCs. Throughout the dissertation, we demonstrated the extent in which maternal obesity, pre-existing DM, GDM, and maternal hypertension may increase the risk of OFC birth defects. The results highlight the need for pre-conceptional program planning for the prevention of OFCs with screening for abnormal glucose tolerance and hypertension.

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7

Crout, Richard Morrow. "Timing of alveolar cleft bone grafting in maxillary alveolar cleft defects." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1446.

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8

Pisoni, L. "THREE-DIMENSIONAL ANALYSIS OF PALATE MORPHOLOGY IN UNILATERAL CLEFT LIP AND PALATE CHILDREN." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/252652.

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Abstract Object: The aim of this study was to evaluate the effects of the orthopedic treatment (performed either by using active or passive plates) and the subsequent surgical treatment on the palatal size and shape of dental casts of patients with unilateral cleft lip and palate (UCLP). Material and methods: 96 palatal cast models, obtained from 32 neonatal patients with UCLP, attending the Fundacion Clinica Noel de Medellin (Colombia) were analyzed using a 3D stereophotogrammetric system in three different time points: before the orthopedic treatment, before and after cheiloplasty. Half of the patients were treated with a passive plate, while the other patients received an active plate. The areas and volumes of the greater and minor segments were obtained using a new measurement protocol. Method repeatability both within and between operators was evaluated using the Paired Student’s t-test and the technical error of measurement (TEM). Area and volume measurements were compared with a three-way repeated measures analysis of variance (ANOVA) to determine differences between plates, alveolar segments and time. Results: No systematic measurement errors were found for both inter-operator and intra-operator’s tracings (p>0.05; TEM<0.32 cm2). No differences were found for the kind of plates (active or passive). Significant differences were found in alveolar segment and time in both area and volume (p<0.01). Conclusions: We showed that area and volume measurement by the 3D stereophotogrammetric system was a repeatable and reliable method of evaluating the stone casts of patients with UCLP. Data obtained were helpful to quantify changes occurring in maxillary arches of UCLP patients after orthopedic and surgical treatments. However, further investigation is needed to especially evaluate the effects of plates, increasing the number of additional time points and expanding the number of patients.

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9

Chan, Ka-ki Rebecca. "Attitudes towards cleft palate effects of personal contact /." Click to view the E-thesis via HKUTO, 2001. http://sunzi.lib.hku.hk/hkuto/record/B36207858.

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Thesis (B.Sc)--University of Hong Kong, 2001.
"A dissertation submitted in partial fulfilment of the requirements for the Bachelor of Science (Speech and Hearing Sciences), The University of Hong Kong, May 4, 2001." Also available in print.

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10

Hunt, O. T. "The psychosocial effects of cleft lip and palate." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411065.

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11

Madhoun, Lauren Louise. "Feeding Infants with Cleft Lip and/or Palate." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543409768755871.

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12

Louw, Brenda. "Cleft Lip / Palate: Best Practices and Recent Developments." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/2149.

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13

Nicholls, Wendy. "Cleft lip and palate – a comparative psychosocial study." Thesis, Curtin University, 2017. http://hdl.handle.net/20.500.11937/68288.

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There are considerable psychosocial impacts associated with the condition of cleft lip and palate (CL/P). This thesis investigated patient perceived impacts of CL/P on psychosocial adjustment and sociological life outcomes across three age-groups, and the perceptions of healthcare professionals with regard to confidence in treating those with CL/P. A mixed methods approach found that CL/P had been a lifelong challenge which resulted in positive educational and employment outcomes but poorer relationship and psychosocial outcomes.

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14

Shaw, Diana Frances. "Genetic analysis of non-syndromic and syndromic cleft lip with or without cleft palate." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24564.pdf.

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15

Hui, Edward. "Soft tissue changes following maxillary osteotomies in cleft lip and palate and non-cleft patients." Click to view the E-thesis via HKUTO, 1992. http://sunzi.lib.hku.hk/HKUTO/record/B38628338.

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16

Cheuk, Lai-shan. "Auditory gap detection in patients with cleft lip/palate." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37991279.

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17

Chu, Mee-yee Katie, and 朱美儀. "Audiological status of cleft palate patients in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31251079.

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18

Cheuk, Lai-shan, and 卓麗珊. "Auditory gap detection in patients with cleft lip/palate." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37991279.

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19

Jiang, Chenghui, and 姜成惠. "Investigation of consonants in Putonghua speakers with cleft palate." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2015. http://hdl.handle.net/10722/211152.

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In mainland China, around 20,000 infants with non-syndromic cleft lip and/or palate are born every year. There is a great clinical need for the rigorous investigation of the speech problems in this population. This thesis aimed to investigate the consonant misarticulations in native Putonghua speakers with repaired cleft palate based on a research project comprised of four studies. Misarticulations associated with cleft palate are well established for English and several other Indo-European languages. However, few research articles describing the articulation of Putonghua (standard Mandarin Chinese) speakers with cleft palate have been published in English language journals. Study One reviewed relevant studies published over the past 30 years in Chinese language journals. Thirty-seven articles were analyzed and coded on a number of methodological variables. This critical review identified many methodological issues. These design flaws made it difficult to draw reliable conclusions about characteristic articulation errors. Seeing the methodological shortcomings found in Study One, a cross-sectional approach was used in Study Two to identify common consonant error patterns. Thirty-two speakers with repaired cleft palate were allocated to four groups dependent on age and the type of cleft. Articulation was evaluated based on the Putonghua Segmental Phonology Test and the Deep Test for Cleft Palate Speakers in Putonghua. The data were transcribed using International Phonetic Alphabet conventions by two experienced examiners. Several ‘language universal’ findings were identified. In addition, distinctive features in Putonghua phonology appeared to contribute to the observed language specific error patterns. The following two studies focused on the particularly vulnerable manner of articulation: affricates. The results from Study Three showed that distorted affricates from speakers with repaired cleft palate exhibited distinctive spectral features compared to typical articulation. These spectral findings added objective evidence to support the articulation deviation noted in Study Two. Study Four examined the relationship between spectral moments and perceptual judgment of accuracy for the place of affricate and to explore whether listeners relied on different spectral moments to perceive place of articulation. Both typical and distorted affricates were played to twelve listeners to make a judgment of articulation accuracy using visual analog scaling. Results showed that the third spectral moment (L3) was significantly correlated with perceptual rating of accuracy of place information from typical speakers. For affricates produced by speakers with cleft palate, the first moment (M1) showed a significantly correlation with perceptual judgment of the accuracy of alveolar affricates. Recommendations concerning methodological issues in the perceptual investigation of cleft palate speech were given in the systematic review. For the first time, the speech error study demonstrated the influence of language-specific features on Putonghua cleft palate speech. The spectral study contributed to our understanding of the differences in affricate production between speakers with cleft and their typical speaking peers. The investigation of the relationship between spectral features and the perception of alveolar and retroflex affricates provided specific clinical directions for establishing the correct place of articulation. Further research is needed to explore the contribution of other variables (e.g., age of palatoplasty) to the error patterns identified in the present study.
published_or_final_version
Speech and Hearing Sciences
Doctoral
Doctor of Philosophy

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20

Meyer, Shaina Elizabeth Ms. "Information needs regarding cleft lip and palate: A survey." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429823264.

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21

Chu, Mee-yee Katie. "Audiological status of cleft palate patients in Hong Kong /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22008378.

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22

Puwanun, Sasima. "Developing a tissue engineering strategy for cleft palate repair." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/7175/.

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The most common craniofacial birth defect is cleft defect with an incidence of 1.7:1000 live births. The current treatments involve many steps of surgical procedures and cause morbidity at the donor site when harvesting bone for filling the gap defect. It may be possible to treat cleft palate defects by tissue engineering strategies using osteoprogenitor cells on a biodegradable distensible electrospun scaffolds to form the hard palate. The aims of this project are to select the suitable cell sources, materials, chemical supplementation, and mechanical conditions to enhance matrix mineralization for repairing the bone part of a cleft palate. Human jaw periosteal cells (HJPs), human mesenchymal stem cell derived from bone marrow (hBMSCs), and human embryonic stem cell mesenchymal progenitor (hESMPs) used in this project showed osteogenic potential by depositing calcium deposition on both monolayer and 3D constructs with the requirement of Dex in the culture media. Electrospun poly(?-caprolactone) scaffolds (PCL) are a suitable temporary extracellular matrix for bone tissue engineering. Vascular endothelial growth factor (VEGF) is an important protein for new blood vessel formation. The VEGF secretion was reduced by Dex supplemented culture media in 3D culture, whereas, it was delayed in the monolayer culture. All cell types responded to oscillatory fluid flow (OFF) by using a standard see-saw rocker to stimulate osteogenic differentiation. The cells were more sensitive to OFF when they were supplemented with Dex for enhancing calcium deposition both in monolayer culture and 3D culture and the strongest effect was at the top surface of the scaffolds. The composite nano-hydroxyapatite PCL electrospun scaffold can enhance matrix mineralization compared to the standard PCL scaffold, but there were no additional effects of OFF on these scaffolds. A tri-layer PCL scaffold could support and separate two different cell types (human dermal fibroblasts and human osteoprogenitor cells: both hESMPs and hBMSCs) and also allow osteogenic differentiation for 28 days. The novel tri-layer PCL electrospun membrane developed here is a promising scaffold for tissue engineering for cleft palate repair. Tissue engineering strategy could benefit treatment cleft palate treatment compared to the current treatments (autologous bone graft from iliac crest) to promote bone formation at the defect area and allow normal development of facial structure in the future.

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23

Scherer, Nancy J., A. Lynn Williams, P. J. Henley, A. Lambert, J. Osborne, and L. Lassiter. "Early Verbalizations of Children With and Without Cleft Palate." Digital Commons @ East Tennessee State University, 2000. https://dc.etsu.edu/etsu-works/2098.

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24

Gopal, Rachna, and Brenda Louw. "Adults with Cleft Lip and Palate and Hearing Loss." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/2145.

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Framework and Research Question: The International Classification of Functioning, Disability and Health (ICF) developed by the World Health Organization (WHO 2001) is a framework to address functioning and disability related to a health condition within the context of the individual’s activities and participation in everyday life. Therefore, in addition to the audiologic test battery the individual’s perception of hearing status and its impact on communication should be considered. The aim of this study is to describe the hearing status of Mauritian adultslivingwith CL/P and their perceptions of the role of hearing in their lives

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25

Burdett, David Norman. "6-mercaptopurine induced cleft palate in the hamster : morphological and cellular aspects." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24490.

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A study on the pathogenesis of 6-mercaptopurine induced cleft palate was undertaken using light and electron microscopic, and enzyme acid phosphatase cytochemical techniques. Palatal development in control fetuses was observed in six stages at the gross level and five stages at the histological level. Between days 9:18 (9 days:18 hours) and 10:00 of gestation palatal primordia appeared from the roof of the oronasal cavity, and developed in the vertical direction until day 12:00 of gestation. Between days 12:00 and 13:00 of gestation the palatal shelves became horizontal and fused with one another. During closure the timely appearance of lysosomes was responsible for elimination of the intervening epithelia of the opposing palatal shelves through an intracellular process of autolysis. Gross observations showed that 6-mercaptopurine affected the vertical development of palatal shelves. In contrast to normal development, vertically developing palatal shelves on day 10:00 of gestation showed sublethal injury of the mesenchymal cells characterized by swelling of the perinuclear space and lysosomal development. Subsequently the epithelial cells were damaged, and the basal lamina fragmented and disappeared. The epithelial and mesenchymal cells communicated with one another. Eventually, however, the epithelial and mesenchymal cells recovered and the basal lamina re-established its continuity. It was concluded that sublethal injury of the mesenchymal and epithelial cells following 6-mercaptopurine treatment disturbed the controlled process of cytodifferentiation, and thus affected vertical development of the palatal shelves to develop a cleft palate.
Medicine, Faculty of
Pathology and Laboratory Medicine, Department of
Graduate

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26

Oliveira, Rosana Prado de. "Relação entre os sinais clínicos da fissura de palato submucosa e a sintomatologia específica: uma abordagem preventiva." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/61/61131/tde-29022008-083502/.

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Objetivo: Apontar a prevalência e os achados anatomofuncionais da fissura de palato submucosa (FPSM) com indicação cirúrgica, diante do quadro sintomático, valorizando o diagnóstico e o acompanhamento da evolução do paciente em uma abordagem preventiva. Modelo: Prospectivo, amostra aleatória Local: Hospital de Reabilitação de Anomalias Craniofaciais - Universidade de São Paulo, Bauru. Pacientes: Foram avaliados 50 pacientes com FPSM, sem outros comprometimentos e 7 casos com alterações somente na úvula, na faixa etária de 20 a 46 meses, por ordem de agendamento no HRAC, no período de 1 ano. Principal resultado medido: Análise e descrição quanto à presença dos sinais clínicos específicos da FPSM e à associação com a sintomatologia. Intervenções: Avaliação fonoarticulatória e inspeção clínica. Resultados: Com relação aos sinais clínicos, observaram-se 25 (50,0%)pacientes com a tríade clássica e 25 (50,0%) com 1 ou 2 sinais clínicos. Dos 50 casos de FPSM, 10 (20,0%) mostraram-se sintomáticos e 40 (80,0%), assintomáticos. Houve associação entre a presença da tríade clássica de sinais e a sintomatologia (p= 0,011), associação dos casos sintomáticos e a presença da zona translúcida (p=0,005), alterações na úvula (p= 0,046), bem como do entalhe ósseo (p=0,029). A hipernasalidade esteve presente em 100,0% dos pacientes sintomáticos. A maior parte dos 41 pacientes com fissura pré-forame procurou atendimento nos primeiros meses de vida, devido à fissura labial e apresentou 7,3% de casos sintomáticos. Já dos 9 pacientes com FPSM isolada, 6 procuraram atendimento tardiamente, devido a queixas de fala. O grupo apresentou 77,7% de casos sintomáticos. Conclusão: Uma maior divulgação dos sinais clínicos e sintomas da FPSM entre os profissionais da área de saúde é fundamental para que o diagnóstico e a definição de conduta ocorram a tempo.
Objective: Point out the prevalence and anatomic functional findings of submucous cleft palate (SCP) with surgical indication in relation to the symptomatic aspect by giving importance to diagnosis and follow-up of patient\'s evolution in a preventive approach. Pattern: Prospective study, haphazard samples. Setting: Rehabilitation Hospital of Craniofacial Anomalies, University of São Paulo, Bauru, Brazil. Subjects: Fifty patients with submucous cleft palate (SCP) with no other complications and seven patients with alterations only in the uvula, all of them ranging in age from 1 year 8 months to 3 years 10 months. Main Outcome Measures: Assessment and description on the presence of specific clinical signs of SCP and the association with symptomatology. Interventions: Evaluation of articulatory aspects and clinical examination. Results: As for the clinical signs 25 patients (50%) were identified with the classic triad and 25 (50%) with 1 or 2 clinical signs. Out of 50 cases of SCP, 10 (20%) were symptomatic and 40 (80%) asymptomatic. There was an association between the presence of classic triad and symptomatology (p=0,011). It was also observed a correlation of symptomatic cases and presence of a translucid area (p=0,005) as well as a notch (p=0,029). Hipernasality was present in 100% of symptomatic patients. Most of 41 patients with pre foramen cleft searched for treatment in the first months of life due to cleft lip and showed 7,3% of symptomatic cases. In contrast, 6 out of 9 patients with isolated SCP searched for treament very late due to speech complaints and 77,7% of this group were symptomatic. Conclusion: It is essential to improve knowledge of clinical signs and symptoms of SCP among professionals involved in health services so that the diagnosis and definition of procedures can take place in time.

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27

許嘉榮 and Edward Hui. "Soft tissue changes following maxillary osteotomies in cleft lip and palate and non-cleft patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1992. http://hub.hku.hk/bib/B38628338.

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28

Nash, Penelope Ruth Gifford. "Psychosocial implications of being born with a cleft palate (with instances of additional cleft lip)." Thesis, University of Southampton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334610.

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29

Perkiömäki, M. R. (Marja Riitta). "Craniofacial shape and dimensions as indicators of orofacial clefting and palatal form:a study on cleft lip and palate and Turner syndrome families." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514288708.

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Abstract The aim of this study was to define distinct craniofacial features in subjects with nonsyndromic cleft lip and palate (CLP) and in subjects with Turner syndrome (TS), and to evaluate the resemblance of these features among their family members. This might help in elucidating if there is a parental contribution to possible predisposing craniofacial features in cleft subjects and to the severity of certain distinct craniofacial features in subjects with X chromosome monosomy. The study population consisted of 29 Costa Rican CLP families including unaffected parents and siblings, and of 71 TS (45,X) subjects and members of their families. Based on lateral and frontal cephalometric analyses, cleft family members were characterized by reduced cranial height and head width, greater interorbital and nasal cavity widths, shorter anterior cranial base and palatal lengths, and shorter total face height compared to control values. With respect to these distinct craniofacial features, there were statistically significant associations in anterior cranial base and palatal length, and head, forehead and outer interorbital width measurements between parents and their children with CLP. The sidedness of the cleft in affected children was related to the asymmetry of the nasal cavity width in their parents. The distinct craniofacial features of the TS subjects, such as short clivus, retrognathic position of mandible, and narrow maxilla at the level of first premolars were related to their mothers' corresponding features. The presence of lateral palatine ridges, which were detected in one third of the TS subjects, was related to the narrowness of the posterior palate rather than to the variation in the tongue position. Distinct craniofacial features segregate in cleft family members. The several significant associations in distinct craniofacial dimensions between parents and children with CLP emphasize the importance of genetic factors in the genesis of nonsyndromic orofacial clefting. The present results support the concept that maternal factors contribute to the degree of deficiency in the growth of the cranial base and to the magnitude of mandibular retrognathism of their daughters with TS. Maternal influences may also modify the width of the palate in TS.

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30

Chau, Ha-fong Cynthia. "Single-word intelligibility in Cantonese speakers with repaired cleft palate." Click to view the E-thesis via HKUTO, 2001. http://sunzi.lib.hku.hk/hkuto/record/B36207792.

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Thesis (B.Sc)--University of Hong Kong, 2001.
"A dissertation submitted in partial fulfilment of the requirements for the Bachelor of Science (Speech and Hearing Sciences), The University of Hong Kong, 4th May, 2001." Also available in print.

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31

Sell, Deborah Anne. "Speech in Sri Lankan cleft palate subjects with delayed palatoplasty." Thesis, De Montfort University, 1991. http://hdl.handle.net/2086/10712.

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This investigation was undertaken within the context of the Sri Lankan Cleft Up and Palate Project, probably the largest surgical and research programme to date concerned with the late operated cleft lip and/or palate subject (Mars et al., 1990). This study examines the speech results of88 patients who received palatal surgery by a visiting British surgical team. The main cohort, consisting of 67 nonsyndromic cleft lip and/or palate Sinh ala speaking patients over the age of eight years at palate repair, have been studied longitudinally. All these patients have pre-operative, post-operative, and post-therapy speech recordings. In addition, 21 similar patients below the age of eight years at surgery have been partially examined. 51 patients have further speech recordings at 4 or 5 years post-operatively. Investigations of velopharyngeal function were undertaken using lateral skull X-rays of patients phonating "ee', nasopharyngoscopy, and a perceptual assessment. Post-operative intra-oral examinations were also carried out. A unique method of speech analysis has been devised, and is used to describe the speech results. The results have shown that patients who have established their speech with an unrepaired palate usually have severely disordered speech, with the exception of some patients with less severe clefts. Post-operatively, many patients retain these poor speech patterns, even with some speech therapy support. Post-therapy, only one third of the cohort had normal or near-normal speech, none of whom were adults. The value of palatal closure is very limited if regular speech therapy is not available as a follow-up to surgery. Only 20% of the cohort achieved post-operative velopharyngeal closure, suggesting that palatoplasty is an inadequate surgical procedure for the majority of patients, in particular those who present with major clefts and are older than eight years of age at surgery. The important variables affecting outcome are palatal repair, speech therapy intervention, age, cleft type, nature of pre-operative speech, and nature of surgery. Structural factors in particular velopharyngeal function and also possibly fistulae, in the adult group, are further relevant variables. Criteria for selecting patients for surgery within this type of environment are proposed.

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32

Hall, Melanie. "Children's accounts of the cleft lip and palate care pathway." Thesis, University of Sheffield, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522416.

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33

Baranian, Baharak. "Speech production in Farsi-speaking children with repaired cleft palate." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/16270/.

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Studies have shown that a history of cleft palate often affects speech production. While similar patterns of atypical speech production have been reported across a variety of different, mainly European, languages (Henningsson & Willadsen, 2011), studies on cleft speech production in typologically different, non-European languages may provide important insights into how truly universal cleft speech characteristics are. Farsi, the national language of Iran, may present a particular and interesting challenge in speech production of individuals with cleft palate, on account of its phonological system. This report presents the results of an ongoing study, aiming to identify the speech characteristics of Farsi-speaking children and to compare these with features reported in cleft palate research for other languages. The study used speech data taken from 21 Farsi-speaking children aged between five and ten years old with a repaired cleft palate and a comparison group of five typically-developing children also aged between five and ten, all resident in Tehran, the capital of Iran. Audio and video recordings were made of the participants’ speech production in single word naming and sentence repetition. The data were transcribed using narrow phonetic transcription, and the transcriptions formed the basis for completion of Farsi GOS.SP.ASS forms for each individual participant. From the analyses, atypical speech characteristics were divided into those related to the cleft palate, and those which are described as non-cleft developmental features. Results indicate that the Farsi-speaking children with cleft palate used a range of features previously identified as cleft speech characteristics for other languages. However, some unusual speech features such as retroflex articulation were noted in the data indicating that compensatory strategies can vary according to the language in question. Some of these unusual speech behaviours (e.g., realisation of a tap as a lateral approximant) are attributed to the particular phonetic inventory and phonological system of Farsi. This study of the speech of Farsi-speaking children with repaired cleft palate indicates that not all characteristics of cleft palate speech are universal. There is evidence of some Farsi-specific features. However since the Farsi data does contain many of the cleft-related articulatory and phonological characteristics reported in English and other languages, the findings from this study support the proposal to base a Farsi cleft speech assessment on the UK GOS.SP.ASS assessment.

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34

Taylor, Blair Morgan. "THE PSYCHOSOCIAL EFFECTS OF CLEFT OF THE LIP AND PALATE." Cleveland State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=csu1624475008242102.

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35

Maier, Andreas. "Speech of children with cleft lip and palate : automatic assessment /." Berlin : Logos-Verl, 2009. http://d-nb.info/992551633/04.

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36

Mekonnen, A. M. "Speech production in Amharic-speaking children with repaired cleft palate." Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/3924/.

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37

Al-Awaji, Nisreen N. "Speech production in Arabic speaking children with operated cleft palate." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/7520/.

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This study explores the phonetic and phonological features of speech production associated with cleft palate in Saudi Arabian Arabic-speaking children. It examines data collected using an Arabic version of the GOS.SP.ASS (Sell et al. 1999) developed specifically for this study, to provide an account of the ways in which a history of cleft lip and palate may affect the development of speech in Arabic, and to consider the implications of these findings for our understanding of universal versus language-specific features of speech associated with cleft. The study used speech data taken from 21 Arabic-speaking children aged from four to seven years old, and a control group of five normally developing children aged between four and five, from Riyadh, the capital of Saudi Arabia. Audio and video recordings were made of the participants' speech production in a variety of contexts, including single word production and connected speech production. The data were transcribed using narrow phonetic transcription, and the transcriptions formed the basis for completion of Saudi Arabian GOS.SP.ASS forms for each individual participant. Phonological analysis was carried out on the data from each participant. From these preliminary analyses, descriptions of atypical speech production features were made, and categorised into those associated with the cleft palate, and those which indicated non-cleft developmental difficulties. Furthermore, descriptive analysis was carried out to determine the most and least accurate segments and to explain the relationship between accurately produced segments and the following variables: chronological age, age at repair and type of cleft palate. Individual case studies were conducted to illustrate and exemplify individual differences in the speech of four of the children with cleft palate who have contrasting speech output patterns. These case studies contribute to an exploration of inter- and intra-speaker variability in speech production associated with cleft palate. The results of this study indicate that the speech characteristics of Saudi children with cleft palate are not entirely consistent with previous cross-linguistic studies of cleft palate speech: a series of different compensatory strategies and unusual speech production features emerged in the data which appear to reflect the phonetic and phonological properties of Arabic. Theoretical and clinical implications for assessment and intervention for speech difficulties related to cleft palate are discussed.

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38

Boyce, Sarah, G. Martin, C. Skinner, K. Wetherholt, and N. Scherer. "Communicative Acts and Word Acquisition in Toddlers with Cleft Palate." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/1536.

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39

Scherer, Nancy J., A. Lynn Williams, Ann Kaiser, Kristin Mullins, and Lila Totino. "Speech Production Changes During Early Intervention: Children With Cleft Palate." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/2062.

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40

Lansdon, Lisa Ann. "The role of structural variation in cleft lip and palate." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6172.

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Clefts of the lip and/or palate (CL/P) are one of the most common birth defects in the world occurring about every 1 in 700 live births. Individuals with non-syndromic clefting (NSCL/P) account for about 70% of all cleft cases and exhibit a cleft only whereas syndromic occurrences (SCL/P) include additional cognitive or structural abnormalities. Linkage, genome-wide association, candidate gene, animal model, sequencing and copy number variant (CNV) analyses have been used to study CL/P and have established that it is a heterogeneous, complex disorder. However, the impact of identified sequence variants on protein structure and the contribution of structural genetic variation to CL/P remains poorly understood. In our first analysis we reassessed the phenotype of a 30-year-old individual of SCL/P and noticed phenotypic overlap with Hartsfield syndrome, a rare syndrome resulting from sequence variants in Fibroblast growth factor 1 (FGFR1). We sequenced the coding region of FGFR1 and identified a novel, de novo variant. Due to the fact sequence variants in FGFR1 contribute to multiple syndromes encompassing a wide phenotypic spectrum, we performed an extensive literature search to record every published sequence variant of FGFR1 and mapped it to the protein structure by disease and phenotype. Although no statistically significant protein domain-phenotype correlations were identified, many regions neared significance. This work stresses the need for systematic, comprehensive phenotyping of patients and provides a method for assessing the impact of the location of sequence variants within the 3D structure of the protein. Although rare and common CNVs have been identified in individuals with CL/P, prior to our work no large-scale studies of rare CNVs for the identification of novel clefting genes had been performed. For our second set of analyses, we conducted two such studies, first focusing on a smaller cohort of 140 individuals with NSCL/P from the Philippines to establish our informatic and functional validation pipeline. We used whole-genome tiling arrays to assess rare deletions overlapping genes not previously implicated in clefting, and identified one deletion overlapping Isthmin1 (ISM1) and a deletion just 3’ of the gene in a second affected individual. Functional validation of Ism1 in Xenopus laevis showed strong expression in structures necessary for craniofacial development, and morpholino and CRISPR/Cas9 knockdown of Ism1 resulted in a median cleft lip in some embryos, establishing ISM1 as a novel craniofacial patterning gene. We then expanded our study and assessed genomic CNVs in 1021 individuals with NSCL/P and 81 individuals with SCL/P, finding no differences in CNV number, load or burden between these groups. We also identified 8 putative clefting genes overlapped by deletions in two or more individuals but at a rare (< 1% frequency) in the cohort. Functional validation of these genes using CRISPR/Cas9 in zebrafish and Xenopus tropicalis is currently underway. This work has identified a novel sequence variant leading to the diagnosis of Hartsfield syndrome in an individual with SCL/P, developed an innovative method for assessing the impact of sequence variation on protein structure, improved our understanding of the contribution of CNVs to SCL/P and NSCL/P and identified several putative novel clefting loci which may help explain a portion of the missing heritability of CL/P.

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Hutchinson, Deanna K. "Assessment of Parental Satisfaction with Management of a Child’s Nonsyndromic Cleft Lip and/or Cleft Palate." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1123868325.

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42

Hutchinson, Deanna K. "Assessment of parental satisfaction with management of a child's nonsyndromic cleft lip and/or cleft palate." Cincinnati, Ohio : University of Cincinnati, 2005. http://rave.ohiolink.edu/etdc//view?acc_num=ucin1123868325.

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Thesis (M.S.)--University of Cincinnati, 2005.
Advisor: Howard M. Saal. Title from electronic thesis title page (viewed Mar. 29, 2009). Includes abstract. Keywords: multidisciplinary team; feeding management; cleft lip and palate surgery education. Includes bibliographical references.

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43

Liao, Yu-Fang. "Timing of hard palate repair and facial growth in patients with unilateral cleft lip and palate." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444940/.

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Lateral cephalometric radiographs from the growth archive of the Sri Lankan Cleft Lip and Palate Project were analyzed to elucidate the relationship between timing of hard palate repair and facial growth in patients with unilateral cleft lip and palate (UCLP). One hundred and twenty-five adult patients with nonsyndromic UCLP operated on at different ages for hard palate repair were recruited and their last cephalometric radiographs were used in the cross sectional analysis 104 patients with nonsyndromic UCLP operated on at different ages for hard palate repair and their 290 cephalometric radiographs were available in the longitudinal analysis. The design utilized statistical control for gender, age, and other covariates such as the timing and surgeon of lip repair as well as the technique and surgeon of hard palate repair. Results showed that the length of the alveolar maxilla (PMP-A, p = 0.05) and the anteroposterior alveolar jaw relation (ANB, p 0.05), were related to the timing of hard palate repair. These results suggest that in patients with UCLP late hard palate repair has a smaller adverse effect than early hard palate repair on the forward growth of the maxilla, and that timing of hard palate repair does not significantly affect the growth of the mandible.

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44

Chan, C. K. "Malocclusion Related To Primary Closure Of The Anterior Palate In Complete Cleft Lip And Palate Patients." Thesis, Faculty of Dentistry, 1988. http://hdl.handle.net/2123/5093.

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45

Chen, Kam-fai. "Reverse headgear treatment effect on unilateral cleft lip and palate of Chinese boys." Thesis, Click to view the E-thesis via HKUTO, 1995. http://sunzi.lib.hku.hk/hkuto/record/B43893594.

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46

Murnaghan, Stephen. "An investigation into the role of the protein CASK in the developing mammalian palate." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271001.

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47

Cho, Ka-wun Queenie. "Identification and discrimination of /th/ and /kh/ by children with cleft palate and posterior placement." Click to view the E-thesis via HKU Scholars Hub, 2007. http://lookup.lib.hku.hk/lookup/bib/B42004718.

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Thesis (B.Sc)--University of Hong Kong, 2007.
"A dissertation submitted in partial fulfilment of the requirements for the Bachelor of Science (Speech and Hearing Sciences), The University of Hong Kong, June 30, 2007." Includes bibliographical references (p. 23-27). Also available in print.

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48

Bianco, Anna Monica Rosaria. "Characterization of novel genes insolved in non syndromic cleft lip with or with out cleft palate (NSCLP)." Doctoral thesis, Università degli studi di Trieste, 2010. http://hdl.handle.net/10077/3735.

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2008/2009
Non-syndromic cleft lip with or without cleft palate (NSCLP) is one of the most common birth defect. Genetic studies on human populations have identified numerous predisposing factors, as MYH9 and JARID2, whose role during palatogenesis remains obscure. In order to improve our knowledge on pathogenetic mechanisms, we carried out expression studies during mouse palate development using RNA in situ hybridization. As reference genes (Tgfb3, Irf6, Pvrl1, Foxe1 and Tp63) known to be required for correct palate formation, Jarid2 and Myh9 are expressed in the epithelial cells of the palatine processes before and at the time of contact. Then, this signal decreases and eventually disappears concomitantly with the degradation of the medial epithelial cells. Consistent with these observations, RT-PCR carried out on dissected palatal shelves detected products of Myh9 and Jarid2 from embryonic day E14.0 to E15.0 with a pick at E14.5, the stage when shelves appose in the midline. Taken together, these expression studies strongly support the association studies that designate these genes as predisposing factors for NSCLP. In multifactorial diseases as NSCLP once genetic studies demonstrate association, a major challenge is to identify mutations. In this regard, we started analyzing two in linkage disequilibrium SNPs (rs3752462 of MYH9 and rs2076056 of JARID2) that could be involved in defective splicing mechanisms, as hypothesized on the basis of their localization within splice sites. Using a hybrid minigene assay, however, we demonstrated that none of the allelic variants lead to any aberrant products at least in HeLa cells, the model used for this study. Moreover, we investigated whether alternative splicing events of the Myh9 gene detected in cochlea and brain (Li et al., 2008) could also be found in other tissues and palate. A small insertion of 12 bp between exon 4 and 5 (loop1) due to an alternative splicing was detected in all adult tissues analyzed. The same insertion was not detected in embryonic tissues, such as palatal samples at different stages of development, and brain. These results suggest that the genomic region of loop1 should be investigated in all risk haplotypes to search for pathogenetic variants. In conclusion, further investigations should be planned to explore the role of MYH9 and JARID2 in orofacial development in order to dissect signaling pathways during palate formation and identify the causative variants contributing to NSCLP.
XXII Ciclo
1973

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49

Frazier, Kirsten. "Prevalence and predictors of adverse effects of medical care in patients with cleft lip and palate undergoing facial bone repairs and orthognathic surgical procedures in the United States." Thesis, University of Iowa, 2019. https://ir.uiowa.edu/etd/6735.

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BACKGROUND AND SIGNIFICANCE: Almost 15% of newborns have congenital anomalies that involve the oral and craniofacial regions, but of these congenital anomalies, cleft lip and palate and craniosynostosis are the most common. It is estimated that the incidence of cleft lip and palate is 0.664 in 1000 live births. These patients commonly have skeletal imbalances of the maxillae and mandible that require surgical and orthodontic correction. Orthodontists and oral surgeons play a critical role in identifying the necessary care and ensuring that the patient receives the best quality of care possible. OBJECTIVES: The objective of the current study is to examine the prevalence of adverse effects of medical care and infectious complications in patients with cleft lip/palate undergoing facial bone repairs/orthognathic surgeries in the United States during the years 2012 to 2014. It will also examine the association between patient/hospital related factors and surgical outcomes (including adverse affects of surgery, incidence of infection, etc.) and how these surgical outcomes impact the hospital costs and length of stay in the hospital. MATERIALS AND METHODS: The Nationwide Inpatient Sample (NIS) is a 20% stratified probability sample of hospitalizations occurring in all acute care hospitals in the United States. It is part of the Healthcare Cost and Utilization Project (HCUP) sponsored by the Agency for Healthcare Research and Quality (AHRQ) [12]. Each hospital in this sample provides information on 20% of hospitalizations occurring during the select years. Hospital stratification is based on multiple hospital-associated variables including: hospital location, geographic region, bed size, teaching status, and ownership/control. Each hospitalization is assigned a sampling weight. Patient-related variables are also provided by the hospitals. In this study, this information is used to provide a nationally representative estimate of all hospitalizations and associated outcomes in the United States from 2012-2014. RESULTS: This study includes all 1,785 patients with cleft lip/palate undergoing facial bone repair/orthognathic surgical procedures in the United States during the study period (2012-2014). These results confirm the hypothesis that there are a combination of patient and hospital related factors that contribute to the occurrence of adverse events and that the occurrence of these events is associated with substantial increases in hospital charges and length of hospital stay. CONCLUSION: These study results are a national representative sample of patients with cleft lip/palate undergoing bony facial repair and orthognathic surgery. They reflect the practice patterns and hospitalization outcomes across the United States. These results can serve as a platform for future prospective controlled studies to examine the risk factors associated with adverse effects of medical care for a wide range of surgical procedures. This information is useful for clinicians, health policy makers, and patients so that they can make informed treatment and policy decisions as well as continue to improve surgical procedures and outcomes.

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50

Jayasekera, Tissa R. "Autogenous Secondary Alveolar Bone Grafting In The Treatment Of Cleft Lip And Palate." Thesis, The University of Sydney, 1989. http://hdl.handle.net/2123/4871.

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