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Relevant bibliographies by topics / Clorsulon

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Academic literature on the topic 'Clorsulon'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Clorsulon"

1

Ravines, José, Severino Torrel, Amarante Florián Alcántara, Luis Vargas-Rocha, Judit Estela Manrique, and Juan Rojas-Moncada. "Resistance and sensitivity of <i>Fasciola hepatica</i> against four active anthelminticprinciples in guinea pigs (<i>Cavia porcellus</i>), Cajamarca, Peru." Revista de Investigaciones Veterinarias del Perú 35, no. 2 (2024): e22564. http://dx.doi.org/10.15381/rivep.v35i2.22564.

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The study aimed to evaluate the efficacy of four anthelmintics in the control of Fasciola hepatica at the Estación Experimental del Instituto Nacional de Innovación Agraria (INIA), Baños del Inca, Cajamarca, Perú. Forty guinea pigs from 5 to 12 months of age of the Inka line, naturally infected with F. hepatica (≥1 HPG), not dewormed in the last 4 months, under the same management and feeding system were used. The animals were distributed into four groups (n=10): triclabendazole (25 mg/kg) and closantel (20 mg/kg) orally, clorsulon + ivermectin (15 mg/kg based on clorsulon) and nitroxinil (50

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2

Courtney, C. H., J. K. Shearer, and R. E. Plue. "Efficacy and safety of clorsulon used concurrently with ivermectin for control of Fasciola hepatica in Florida beef cattle." American Journal of Veterinary Research 46, no. 6 (1985): 1245–46. https://doi.org/10.2460/ajvr.1985.46.06.1245.

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SUMMARY The safety and anthelmintic efficacy of clorsulon (7 mg/kg of body weight, orally) given concurrently with ivermectin (0.2 mg/kg, subcutaneously) for control of Fasciola hepatica were evaluated in 75 crossbred beef cattle. Twenty-three control animals were given only ivermectin. Fluke egg counts were significantly lower (P < 0.0001) in clorsulon-treated animals by day 14 after treatment than before treatment (base line) and were significantly lower (P < 0.005) after treatment in clorsulon-treated animals than in controls. There was no significant change in fluke egg counts of con

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Kilgore, R. L., M. L. Williams, G. W. Benz, and S. J. Gross. "Comparative efficacy of clorsulon and albendazole against Fasciola hepatica in cattle." American Journal of Veterinary Research 46, no. 7 (1985): 1553–55. https://doi.org/10.2460/ajvr.1985.46.07.1553.

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SUMMARY In a dosage-confirmation trial, anthelmintic activities of clorsulon and albendazole against Fasciola hepatica were evaluated and compared. Twenty-eight cattle (8 to 12 months old) with natural F hepatica infections were randomly allotted to 4 groups of 7 cattle each: group 1, no treatment (controls); group 2, clorsulon suspension given orally at 3.5 mg/kg of body weight; group 3, clorsulon suspension given orally at 7 mg/kg; and group 4, albendazole paste given orally at 10 mg/kg. At necropsies, performed 7 and 8 days after treatment, control cattle harbored a geometric mean of 133.2

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Vegad, Kunjal L* Paranjape Dipty B. Shah Dhwani A. Patel Ekta D. Patel Yogesh K. Patel Kaushik R. "DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF IVERMECTIN AND CLORSULON IN IVERCAM INJECTION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 523–31. https://doi.org/10.5281/zenodo.1036490.

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A precise, simple, accurate and selective method was developed and validate for estimation of Ivermectin and Clorsulon in Ivercam injection, Reversed phase high performance liquid chromatographic (RP-HPLC) method was developed for routine quantification of Ivermectin and Clorsulon in laboratory prepared mixtures as well as in combined dosage form. Chromatographic separation was achieved on a BDS hypersil C18 (5μ, 250 x 4.6 mm) utilizing mobile phase of filtered and degassed mixture of 60 phosphate buffer (pH 5.5 adjusted with 1% O-phosphoric acid) and Methanol (60:40 v/v) at a flow rate of 1 m

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Sundlof, Stephen F., Ernest L. Bliss, Ellis C. Greiner, Thang Q. Tran, and Mary A. Wertenberger. "Efficacy of clorsulon for the treatment of experimentally induced infections of Fasciola hepatica in goats." American Journal of Veterinary Research 52, no. 1 (1991): 111–14. http://dx.doi.org/10.2460/ajvr.1991.52.01.111.

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SUMMARY A dose titration study was undertaken to determine the efficacy of clorsulon against the adult stage of Fasciola hepatica in goats. Thirty-nine goats were experimentally infected with metacercariae of F hepatica. At 14 weeks after infection, each goat was assigned randomly to 1 of 5 groups. Goats in groups 1 to 4 received a single oral administration of clorsulon at dosages of 3.5, 7, 11, and 15 mg/kg of body weight, respectively. The fifth group of goats (control group) was infected with F hepatica, but were not treated with clorsulon. Postmortem examination of goats at 3 weeks after

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6

Foreyt, William J. "Evaluation of clorsulon against immature Fascioloides magna in cattle and sheep." American Journal of Veterinary Research 49, no. 7 (1988): 1004–6. https://doi.org/10.2460/ajvr.1988.49.07.1004.

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SUMMARY Efficacy of clorsulon was evaluated against infection with immature Fascioloides magna in 24 cattle and 12 sheep. Infections were induced by oral administration of 600 metacercariae/host. In cattle, clorsulon at dosages of 7 and 21 mg/kg of body weight was 65 and 100% effective against 8-week-old flukes, and 20 and 74% effective against 16-week-old flukes, respectively. In sheep, clorsulon at a dosage of 21 mg/kg was 92% effective against 8-week-old flukes. Significantly (P < 0.05) more F magna were recovered from untreated sheep than from untreated cattle.

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7

Ferraroni, Marta, Andrea Angeli, Simone Carradori, and Claudiu T. Supuran. "Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies." Acta Crystallographica Section D Structural Biology 78, no. 3 (2022): 321–27. http://dx.doi.org/10.1107/s2059798322000079.

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Clorsulon is an anthelmintic drug that is clinically used against Fasciola hepatica. Due to the presence of two sulfonamide moieties in its core nucleus, which are well recognized as zinc-binding groups, it was proposed that it may be efficacious in the inhibition of parasite carbonic anhydrases (CAs). Proteomic analyses revealed the presence of CA in the tegument of Schistosoma mansoni, and recently the druggability of this target was explored by testing the inhibitory activities of several sulfonamide-based derivatives. According to the principles of drug repurposing, the aim was to demonstr

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Foreyt, William J., and John R. Gorham. "Ineffectiveness of clorsulon against Nanophyetus salmincola in coyotes." Journal of the American Veterinary Medical Association 189, no. 9 (1986): 1101–2. https://doi.org/10.2460/javma.1986.189.09.1101.

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SUMMARY Efficacy of clorsulon against the trematode Nanophyetus salmincola was evaluated in coyotes. Ten 16-week-old coyote pups were fed fish that contained metacercariae of N salmincola. Twenty-one days later, 5 of the coyotes were given a suspension of clorsulon (approx 16 mg/kg of body weight, orally). Within 30 days after treatment, the numbers of fluke eggs in fecal specimens from the 5 treated coyotes had not decreased, and numbers of fluke eggs and flukes recovered from treated coyotes at necropsy did not differ from numbers of fluke eggs and flukes recovered from 5 untreated coyotes.

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Conboy, G. A., B. E. Stromberg, and J. C. Schlotthauer. "Efficacy of clorsulon against Fascioloides magna infection in sheep." Journal of the American Veterinary Medical Association 192, no. 7 (1988): 910–12. https://doi.org/10.2460/javma.1988.192.07.910.

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Summary In a study to evaluate the efficacy of clorsulon against Fascioloides magna infection in sheep, 12 ewes were inoculated orally with 100 metacercariae of F magna, and 6 were treated with clorsulon (15 mg/kg of body weight) 8 weeks after inoculation. The sheep were euthanatized 16 weeks after inoculation, flukes were recovered, and the liver and other tissues were subjectively scored for the severity of lesions (0 to 4 + ). The number of flukes recovered from the clorsulon-treated group (3.8 ± 1.2 flukes) was significantly (P = 0.025) lower than the number of flukes recovered from the gr

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Zivmerman, Gary L., Dennis H. Wallace, Debra J. Schons, and Eric P. Hoberg. "Efficacy of clorsulon against mature, naturally acquired Fasciola hepatica infections in cattle and sheep." American Journal of Veterinary Research 47, no. 8 (1986): 1665–67. https://doi.org/10.2460/ajvr.1986.47.08.1665.

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SUMMARY Clorsulon (3.5 or 7 mg/kg of body weight) was given orally to mature cows (dairy or beef) and to mature mixed-breed sheep harboring patent infections of Fasciola hepatica. Eighteen animals of each species were assigned to a control group (drug vehicle) or to 1 of 2 treatment (3.5 or 7.0 mg/kg) groups of 6 animals each. On posttreatment days 8 (cows) or 14 (sheep), the animals were slaughtered for recovery of flukes. In cows, the efficacy (P values for treatment groups vs control) of clorsulon against infections of mature F hepatica was 99.21% (P ≤ 0.0065) at 3.5 mg/kg and was 100% (P ≤

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Dissertations / Theses on the topic "Clorsulon"

1

Meaney, M. "The morphological response of 'Fasciola' species to clorsulon and triclabendazole, their uptake and synergistic interaction." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426664.

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Books on the topic "Clorsulon"

1

Brown, Vernon K. Animal Pharm's new product review: No.1 clorsulon : a review of the scientific literatureon clorsulon, a new treatment for fascioliasis. V & O Publications Ltd, 1987.

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Book chapters on the topic "Clorsulon"

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Mehlhorn, Heinz. "Clorsulon." In Encyclopedia of Parasitology. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_4134.

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Mehlhorn, Heinz. "Clorsulon." In Encyclopedia of Parasitology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27769-6_4134-1.

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