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Journal articles on the topic 'Clostridium perfringens'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Oskutis, Morgan, and Matthew Reaven. "Septic Shock and Spontaneous Gangrenous Gas Necrosis of the Spleen Secondary to Clostridium perfringens: The Importance of Source Control." Case Reports in Critical Care 2021 (May 6, 2021): 1–4. http://dx.doi.org/10.1155/2021/5563071.

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Clostridium perfringens is a rare cause of septic shock, occurring most frequently in immunocompromised patients. An uncommon cause of Clostridium perfringen septicemia is spontaneous gangrenous gas necrosis of the spleen, where the primary treatment is splenectomy. We present a case of septic shock caused by spontaneous gangrenous gas necrosis of the spleen secondary to Clostridium perfringens in a patient whose profound pancytopenia made obtaining definitive source control extremely difficult.

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2

Shastin, P. N., V. A. Savinov, A. I. Laishevtsev, E. D. Mandryka, E. A. Fabrikantova, and A. V. Supova. "Clostridium species diversity in cattle." Veterinary Science Today 14, no. 2 (2025): 194–200. https://doi.org/10.29326/2304-196x-2025-14-2-194-200.

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Introduction. Clostridial infections, though relatively sporadic, are globally ubiquitous and specified by high mortality rates, resulting in substantial economic losses to agriculture. In cattle, pathogenic сlostridia cause diseases such as enterotoxemia, malignant edema, tetanus, and botulism. The most clinically significant species include Clostridium septicum, Clostridium perfringens, Clostridium chauvoei, Clostridium novyi, and Clostridium sordellii.Objective. Study of Clostridium spp. diversity by examination of autopsy samples and sections of cattle from different regions of Russia; det

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3

Jerram, Lucy. "Clostridial disease in cattle." Livestock 24, no. 6 (2019): 274–79. http://dx.doi.org/10.12968/live.2019.24.6.274.

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Clostridial disease affects cattle across the UK throughout the year but particularly in the grazing season. All clostridial disease occurs when conditions in the muscles or organs become anaerobic allowing for bacterial proliferation and toxin production. The most common pathogenic clostridium is Clostridium chauvoei which causes blackleg and has both skeletal and cardiac forms. Clostridium perfringens is the second most commonly identified clostridia with type A causing enterotoxaemia and type D causing pulpy kidney. Clostridium novyi is the third most common clostridia — type B causes black

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4

Bezborodova, Natalia A., Evgenia N. Shilova, Veronika V. Kozhukhovskaya, Vladlena D. Zubareva, Olga V. Sokolova, and Nikolai A. Martynov. "Improvement of Laboratory Diagnosis for Detection and Identification of Bovine Clostridiosis." WSEAS TRANSACTIONS ON BIOLOGY AND BIOMEDICINE 20 (November 1, 2023): 305–12. http://dx.doi.org/10.37394/23208.2023.20.31.

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Objective: Clostridiosis is a toxic infectious disease; the pathogenicity factor of causative agents is the secreted toxins. A characteristic feature of clostridiosis pathogens is their polytropism. They affect both humans and agricultural, domestic, and wild animals. Our research aimed to monitor Clostridium perfringens and Clostridium difficile spread among agricultural organizations of the Ural region. Materials and Methods: 137 biological samples were obtained from cattle with symptoms of clostridial infection. For PCR species and toxinotype identification commercial kits and previously de

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5

Liu, Ying, Jianfei Zhu, Shaoqi Qu, Jianzhong Shen, and Kui Zhu. "Plant-Derived Xanthones against Clostridial Enteric Infections." Antibiotics 12, no. 2 (2023): 232. http://dx.doi.org/10.3390/antibiotics12020232.

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Intestinal bacterial infections are a major threat to human and animal health. In this study, we found plant-derived antibacterial xanthones, particularly α-mangostin (AMG) from the mangosteen peel, exhibiting extraordinary activities against Clostridium perfringens. Structure–activity relationship analysis showed that prenylation modulated the activity of xanthones. The efficacy of AMG (4, 8, 20 mg/kg body weight) was also demonstrated in the broiler chicken necrotic enteritis model infected with Clostridium perfringens. In the models (n = 6 per group), feed supplementation of AMG maintained

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6

SHEFF, BARBARA. "Clostridium perfringens." Nursing 34, no. 8 (2004): 31. http://dx.doi.org/10.1097/00152193-200408000-00031.

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7

Fouch, Sarah. "Clostridium perfringens." Biomedical & Life Sciences Collection 2024, no. 11 (2024): e1006472. http://dx.doi.org/10.69645/guhw2393.

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8

Sheff, Barbara. "Clostridium perfringens." Nursing (Ed. española) 23, no. 7 (2005): 50. http://dx.doi.org/10.1016/s0212-5382(05)71474-6.

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9

Kristopaitis, Theresa, Randy Jensen, and Meena Gujrati. "Clostridium perfringens:." Surgical Neurology 51, no. 4 (1999): 448–51. http://dx.doi.org/10.1016/s0090-3019(97)00454-0.

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10

Labbé, Ronald G. "Clostridium perfringens." Journal of AOAC INTERNATIONAL 74, no. 4 (1991): 711–14. http://dx.doi.org/10.1093/jaoac/74.4.711.

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Abstract In the United States and Canada, Clostridium perfringens remains a leading cause of bacterial food poisoning in humans. It has been primarily associated with meat and poultry products prepared in food service establishments. Fecal spore levels of 104 or more per g are considered indicative of a food poisoning outbreak. However, elevated spore levels of this organism are frequently seen in healthy elderly individuals, an observation that complicates investigations of suspected outbreaks. Recent studies with this population indicate that fecal enterotoxin levels are a valuable and effec

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11

Bueschel, Dawn, Richard Walker, Leslie Woods, John Kokai-Kun, Bruce McClane, and J. Glenn Songer. "Enterotoxigenic Clostridium perfringens type A necrotic enteritis in a foal." Journal of the American Veterinary Medical Association 213, no. 9 (1998): 1305–7. http://dx.doi.org/10.2460/javma.1998.213.09.1305.

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Clostridium perfringens is the most common cause of clostridial enteric disease in domestic animals. Many individuals have suggested that isolation of C perfringens type A from a horse with enteric disease is of little importance, even when other likely causes are ruled out; however, it appears that enterotoxigenic C perfringens type A may cause enteric disease in horses.

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12

Uzal, Francisco A., Mauricio A. Navarro, Javier Asin, and Eileen E. Henderson. "Clostridial Diseases of Horses: A Review." Vaccines 10, no. 2 (2022): 318. http://dx.doi.org/10.3390/vaccines10020318.

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The clostridial diseases of horses can be divided into three major groups: enteric/enterotoxic, histotoxic, and neurotoxic. The main enteric/enterotoxic diseases include those produced by Clostridium perfringens type C and Clostridioides difficile, both of which are characterized by enterocolitis. The main histotoxic diseases are gas gangrene, Tyzzer disease, and infectious necrotic hepatitis. Gas gangrene is produced by one or more of the following microorganisms: C. perfringens type A, Clostridium septicum, Paeniclostridium sordellii, and Clostridium novyi type A, and it is characterized by

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13

Maikanov, Balgabay, Raikhan Mustafina, Laura Auteleyeva, et al. "Clostridium botulinum and Clostridium perfringens Occurrence in Kazakh Honey Samples." Toxins 11, no. 8 (2019): 472. http://dx.doi.org/10.3390/toxins11080472.

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The aim of this study was to assess occurrence of Clostridium botulinum and Clostridium perfringens in honey samples from Kazakhstan. Analyses were carried out using a set of PCR methods for identification of anaerobic bacteria, and detection of toxin genes of C. botulinum and C. perfringens. Among 197 samples, C. botulinum was noticed in only one (0.5%). The isolated strain of this pathogen showed the presence of the bont/A and ntnh genes. C. perfringens strains were isolated from 18 (9%) samples, and mPCR (multiplex PCR) analysis led to them all being classified as toxin type A with the abil

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14

Saksena, Nitin K., and Nicole Truffaut. "Cloning of tetracycline-resistance genes from various strains of Clostridium perfringens and expression in Escherichia coli." Canadian Journal of Microbiology 38, no. 3 (1992): 215–21. http://dx.doi.org/10.1139/m92-036.

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One hundred strains of Clostridium perfringens and 52 strains of other Clostridia of human and animal origins were screened for tetracycline resistance. Fifty-six strains were resistant to tetracycline in the C. perfringens group. Ten strains were selected for their high level of resistance. In all of them, the tetracycline-resistance genes were found to be residing in large plasmids of about 50 kb, all showing homologies. Several tetracycline-resistance genes from plasmids of various strains of C. perfringens were cloned in plasmid pUC19 and the resistance was expressed in Escherichia coli. H

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15

ABEYTA, CARLOS, ANITA MICHALOVSKIS, and MARLEEN M. WEKELL. "Differentiation of Clostridium perfringens from Related Clostridia in Iron Milk Medium." Journal of Food Protection 48, no. 2 (1985): 130–34. http://dx.doi.org/10.4315/0362-028x-48.2.130.

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The stormy fermentation reaction of Clostridium perfringens in iron milk medium was compared to that of several C. perfringens-like strains. These clostridia, C. barati, C. perenne, C. absonum, and C. paraperfringens are very similar to C. perfringens on the basis of certain biochemical reactions and, consequently, are often difficult to distinguish from C. perfringens. Furthermore, these related clostridia may also be present in foods. Results of this study demonstrate that after 18 h of incubation at 45°C, only C. perfringens gave a positive reaction in iron milk with inocula as low as 22 ce

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16

Songer, J. Glenn, and Francisco A. Uzal. "Clostridial Enteric Infections in Pigs." Journal of Veterinary Diagnostic Investigation 17, no. 6 (2005): 528–36. http://dx.doi.org/10.1177/104063870501700602.

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Clostridium perfringens types A and C and Clostridium difficile are the principal enteric clostridial pathogens of swine. History, clinical signs of disease, and gross and microscopic findings form the basis for a presumptive diagnosis of C. perfringens type-C enteritis. Confirmation is based on isolation of large numbers of type-C C. perfringens and/or detection of beta toxin in intestinal contents. Diagnosis of C. perfringens type-A infection, however, remains controversial, mostly because the condition has not been well defined and because type-A organisms and their most important major (al

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17

Faiz, Muhammad Muhammad Kamran Taj Abbul Wadood1 Imran Taj Ghulam Muhammad Saeed Ahmed Essote Shairbaz Khan Tayaba Sohail Ajaz-ul-Haq Naimat Ullah. "ISOLATION OF CLOSTRIDIUM PERFRINGEN FROM FISHES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 06, no. 01 (2019): 566–70. https://doi.org/10.5281/zenodo.2533217.

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<em>In present study C. perfringens were isolated from the fishes of Quetta, Balochistan. Total 240 samples were collected out of which 60% were positive for C. perfringens while 40% were negative. The area wise distribution of positive sample between Kasi road market was 21%, Joint road market was 25%, and Summugli road market was 13%. The C. perfringens was confirmed through gram staining, different biochemical tests and different sugar fermentation tests. The different drug result showed that C. perfringens was sensitive to Erythromycin (12mm), Spectinomycin (6mm), Lincomycin (15mm), Merope

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18

Alwan, Jabbar A., Ali A. Al-zaidy, and Kadhim H. Abbas. "Real-Time PCR for direct detection of Clostridium perfringens from horse with enterocolitis infection." Kufa Journal For Veterinary Medical Sciences 7, no. 1 (2016): 74–80. http://dx.doi.org/10.36326/kjvs/2016/v7i14286.

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Clostridium perfringens is one of the most important causative agents of enterocolitis infection in horses. This bacterium capable to produce potential enterotoxin that cause diarrhea in horses. This study was aimed to molecular identification of Clostridium perfringens from horses infected by diarrhea by using Real-Time PCR technique. The Clostridium perfringens type C was identified by using specific primers for enterotoxin (CPE) gene that designed in this study using NCBI-Genbank data base (Genbank code: GQ225719.1) and primer3 plus for primer design. The results show that prevalence of inf

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19

Maaji, E. C., S. N. G. Kia, and M. Bello. "Search for the Occurrence of Clostridium difficile and Clostridium perfringens in Pigs Within Zaria and Environs, in Kaduna State, Nigeria." Folia Veterinaria 64, no. 2 (2020): 11–19. http://dx.doi.org/10.2478/fv-2020-0012.

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AbstractAnimals have been known to be the main study subjects when investigating the epidemiology of zoonotic Gram-positive Clostridium difficile and Clostridium perfringens. This cross-sectional study was aimed at determining the occurrence of C. difficile and C. perfringens in pigs as well as the associated risk factors within Zaria and environs, in Kaduna State of Nigeria. A pre-sampling survey led to the selection of Shika, Samaru and Ungwan Mangu in the pig farming communities of Zaria and environs in Kaduna North as the study sites. Rectal swabs from 132 pigs were obtained and anaerobica

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20

Chand, Mastian, Ellen Gutkin, Sang H. Kim, Carl Urban, and Melvin C. Hochman. "Clostridium perfringens Septicemia." Infectious Diseases in Clinical Practice 20, no. 2 (2012): 115–18. http://dx.doi.org/10.1097/ipc.0b013e318234c3bf.

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21

Wiles, Stephen B., and Carl H. Ide. "Clostridium perfringens Endophthalmitis." American Journal of Ophthalmology 111, no. 5 (1991): 654–56. http://dx.doi.org/10.1016/s0002-9394(14)73721-3.

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22

Titball, Richard W. "Clostridium perfringens vaccines." Vaccine 27 (November 2009): D44—D47. http://dx.doi.org/10.1016/j.vaccine.2009.07.047.

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23

Abu El-Asrar, Ahmed M., and Khalid F. Tabbara. "Clostridium perfringens endophthalmitis." Documenta Ophthalmologica 87, no. 2 (1994): 177–82. http://dx.doi.org/10.1007/bf01204795.

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24

McClane, Bruce A., Philip C. Hanna, and Andrew P. Wnek. "Clostridium perfringens enterotoxin." Microbial Pathogenesis 4, no. 5 (1988): 317–23. http://dx.doi.org/10.1016/0882-4010(88)90059-9.

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25

Bajpai, Vijeta, Aishwarya Govindaswamy, Sonu Kumari Agrawal, Rajesh Malhotra, and Purva Mathur. "Clostridium sordelli as a cause of gas gangrene in a trauma patient." Journal of Laboratory Physicians 11, no. 01 (2019): 094–96. http://dx.doi.org/10.4103/jlp.jlp_108_18.

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AbstractGas gangrene is a necrotic infection of the skin and soft tissue that is associated with high mortality and often necessitating amputation to control the infection. Clostridial myonecrosis is most often cause of gas gangrene and usually present in settings of trauma, surgery, malignancy, and other underlying immunocompromised conditions. The most common causative organism of clostridial myonecrosis is Clostridium perfringens followed by Clostridium septicum. Here, we are reporting an unusual case report of posttraumatic gas gangrene caused by Clostridium sordelli.

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26

Issimov, Arman, Torebek Baibatyrov, Aigul Tayeva, et al. "Prevalence of Clostridium perfringens and Detection of Its Toxins in Meat Products in Selected Areas of West Kazakhstan." Agriculture 12, no. 9 (2022): 1357. http://dx.doi.org/10.3390/agriculture12091357.

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Objectives. The current study aimed to investigate the prevalence of Clostridium perfringens in meat products at meat fairs in four cities of West Kazakhstan from April to October 2021. Methods. In total, 240 samples were collected and subsequently examined for the presence of Clostridium perfringens and its associated toxins using a standard culture method and multiplex PCR assay. Results. In the 240 samples, 67 (30%) tested positive for Clostridium perfringens. All isolates were classified as biotype A with the ability to produce α toxin. The prevalence of Clostridium perfringens was found i

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27

Donaldson, Mark T., and Jonathan E. Palmer. "Prevalence of Clostridium perfringens enterotoxin and Clostridium difficile toxin A in feces of horses with diarrhea and colic." Journal of the American Veterinary Medical Association 215, no. 3 (1999): 358–61. http://dx.doi.org/10.2460/javma.1999.215.03.358.

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Objective To determine prevalence of clostridial enterotoxins in feces of horses with diarrhea and colic, and to determine whether an association exists between detection of clostridial enterotoxins in feces and development of diarrhea as a complication of colic. Design Prospective case series and case-control study. Animals 174 horses with diarrhea, colic, or problems not related to the gastrointestinal tract. Procedure Horses were assigned to 1 of 4 groups: colic with diarrhea (group 1; n = 30); colic without diarrhea (group 2; 30); diarrhea without colic (group 3; 57); and control (group 4;

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28

Firdous, bugti Muhammad Kamran Taj* Imran Taj Ghulam Mohammad Shakeel Ahmed Farooq Shahzad Umbreen Zafar Summiya Baloch Marina Panezai3 Saima Azam. "ISOLATION AND IDENTIFICATION OF CLOSTRIDIUM PERFRINGENS CAUSING ENTEROTOXAEMIA IN BOVINE OF KACCHI DISTRICT BALOCHISTAN." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 3024–31. https://doi.org/10.5281/zenodo.1235961.

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The causal agent of necrotic enteritis was isolated from the bovine of kacchi district Balochistan. Total 200 fecal samples were collected, out of which 74% samples were positive and 26% were negative for Clostridium perfringens. The age wise distribution was 20 % in 6 month, 16 % in 1 year, 13% in 2 years, 11% in 3 years, 8% in 4 years and 6% in 5 years. However species wise results showed that the cattle were 54% and buffaloes were 20% affected with enterotoxaemia. The season wise result showed that the incidence of enterotoxaemia was more in spring season. Clostridium perfringens was confir

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Kronfeld, Hanna, Nicole Kemper, and Christina S. Hölzel. "Phenotypic and Genotypic Characterization of C. perfringens Isolates from Dairy Cows with a Pathological Puerperium." Veterinary Sciences 9, no. 4 (2022): 173. http://dx.doi.org/10.3390/vetsci9040173.

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Clostridium perfringens (C. perfringens) forms part of the intestinal microbiome, but is also a known pathogen in histotoxic infections. The significance of the pathogen as a cause of uterine infections in cattle has been little studied so far. Here, we analyzed the association between a pathological puerperium in cattle and the detection of C. perfringens in a prospective longitudinal study. Clostridium perfringens were only found in vaginal and uterine samples of diseased cattle, and were absent in healthy controls. Isolates (n = 21) were tested for the production of major toxins (alpha-, be

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30

Bryant, Christopher S., Latoya Perry, Jay P. Shah, Sanjeev Kumar, and Gunter Deppe. "Life-Threatening Clostridial Sepsis in a Postmenopausal Patient with Degenerating Uterine Leiomyoma." Case Reports in Medicine 2010 (2010): 1–3. http://dx.doi.org/10.1155/2010/541959.

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Clostridium perfringensis a fulminant infection that affects patients with a high rate of morbidity and mortality. Fortunately,C. perfringens-associated sepsis and death in the gynecologic patient is rarely encountered. We report a case of intrauterineC. perfringenspresenting as life-threatening sepsis in a postmenopausal patient.

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Ndeereh, David, Benson Okita-Ouma, Jamie Gaymer, Mathew Mutinda, and Francis Gakuya. "Unusual mortalities of the eastern black rhinoceros (Diceros bicornis michaeli) due to clostridial enterotoxaemia in Ol Jogi Pyramid Sanctuary, Kenya." Pachyderm 51 (June 30, 2012): 45–51. http://dx.doi.org/10.69649/pachyderm.v51i.289.

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Nine eastern black rhinoceroses (Diceros bicornis michaeli) developed clinical clostridial enterotoxaemia between May and July 2010 in the Pyramid Black Rhino Sanctuary within the Ol Jogi Conservancy, Laikipia, Kenya. The rhinos presented with a per-acute syndrome characterized by severe abdominal pain manifested by struggling and rolling on the ground and laboured breathing, and they died within three hours after being sighted sick. Necropsy and histopathology revealed severe pathology in the gastro-intestinal tract. Grossly, the small and large intestines were congested and oedematous. All t

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32

Neut, Christel, Jayant Pathak, Charles Romond, and Henri Beerens. "Rapid Detection of Clostridium perfringens: Comparison of Lactose Sulfite Broth with Tryptose-Sulfite-Cycloserine Agar." Journal of AOAC INTERNATIONAL 68, no. 5 (1985): 881–83. http://dx.doi.org/10.1093/jaoac/68.5.881.

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Abstract The lactose sulfite (LS) medium recommended for the detection and identification of Clostridium perfringens in foods was compared with a reference method using tryptose-sulfite-cycloserine (TSC) agar for the enumeration of this organism in a variety of foods and food ingredients. C. perfringens was detected and enumerated in 17 of the 54 samples examined with LS broth, but its presence could be confirmed in only 9 of the samples with TSC agar. In only 2 instances, C. perfringens was detected on TSC agar but not in LS broth. A positive response (FeS + and gas +) in LS broth incubated a

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33

Neut, Christel, Jayant Pathak, Charles Romond, and Henri Beerens. "Rapid Detection of Clostridium perfringens: Comparison of Lactose Sulfite Broth with Tryptose- Sulfite-Cycloserine Agar." Journal of AOAC INTERNATIONAL 68, no. 5 (1985): 881–83. http://dx.doi.org/10.1093/jaoac/68.5.884.

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Abstract The lactose sulfite (LS) medium recommended for the detection and identification of Clostridium perfringens in foods was compared with a reference method using tryptose-sulfite-cycloserine (TSC) agar for the enumeration of this organism in a variety of foods and food ingredients. C. perfringens was detected and enumerated in 17 of the 54 samples examined with LS broth, but its presence could be confirmed in only 9 of the samples with TSC agar. In only 2 instances, C. perfringens was detected on TSC agar but not in LS broth. A positive response (FeS + and gas +) in LS broth incubated a

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34

El-Helw, H. A., M. M. Taha, Elham F. El-Sergany, Ebtesam, E. Z. Kotb, A. S. Hussein, and Y. A. Abdalla. "Identifying the Virulent Factors of Clostridium perfringens Locally Isolated from Different Species." World's Veterinary Journal 10, no. 4 (2020): 617–24. http://dx.doi.org/10.54203/scil.2020.wvj74.

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Clostridium perfringens incriminated in many diseases among different species of animals due to its ability to produce many virulence factors. In the current study, 135 intestinal samples were collected from different animal species of different localities in Egypt. Samples were subjected to isolation and identification (morphologically and biochemically) for obtaining Clostridium perfringens isolates (n=26, 19.25%). The PCR was carried out to elucidate the virulence factors. It was indicated that all the 26 Clostridium perfringens isolates had CPA gene and Clostridium perfringens enterotoxin

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35

Koubaissi, Salwa A., Reem G. Al Assaad, Ziad Itani, and Imad Bouakl. "Black Urine and Methemoglobinemia in the Setting of Sepsis Due to Clostridium Perfringens." Clinical Medicine Insights: Case Reports 13 (January 2020): 117954762098189. http://dx.doi.org/10.1177/1179547620981894.

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Clostridium Perfringens is an anaerobic gram-positive bacillus able to produce different types of toxins and can cause septicemia. The mechanism is through translocation from a previously colonized gastrointestinal or genital tract. Massive intravascular hemolysis induced by this bacterium is a rare presentation reported in only 7% to 15% of cases of Clostridium Perfringens bacteremia with a mortality rate reaching 90%.We present the case of a middle-aged man with metastatic melanoma having black-colored urine as the first sign of massive hemolysis along with mild methemoglobinemia. Despite ti

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Simon, Tracey G., Joanna Bradley, Adisa Jones, and Gerardo Carino. "Massive Intravascular Hemolysis From Clostridium perfringens Septicemia." Journal of Intensive Care Medicine 29, no. 6 (2013): 327–33. http://dx.doi.org/10.1177/0885066613498043.

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We describe the case of a patient with hemolysis-associated Clostridium perfringens septicemia and review all similar cases published in the literature since 1990, with specific focus on the relationship between treatment strategy and survival. We searched PubMed for all published cases of C. perfringens-associated hemolysis, using the medical subject terms “clostridia,” “clostridial sepsis,” and/or “hemolysis.” All case reports, case series, review articles, and other relevant references published in the English literature since 1990 were included in this study. There were no exclusion criter

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Gale, Christina, Eduardo Velazquez, and Daniel Sperling. "The role of Clostridium perfringens in neonatal diarrhoea and the importance of effective control." Livestock 27, no. 3 (2022): 120–26. http://dx.doi.org/10.12968/live.2022.27.3.120.

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Neonatal diarrhoea is a large economic and animal health problem on pig farms worldwide. There are numerous factors involved in the disease, one of which being the pathogen Clostridum perfringens. Various types of Clostridium perfringens exist, including Type A (CpA), which produces toxins that have pathogenic effects on the pig. The alpha (CPA) and beta2 toxins (CPB2) are suggested as contributors to the virulence of the pathogen as they result in damage and changes to the gastrointestinal tract of the pig. Therefore, performance losses can be observed as well as the clinical diarrhoea seen o

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Huang, I.-Hsiu, and Mahfuzur R. Sarker. "Complementation of a Clostridium perfringens spo0A Mutant with Wild-Type spo0A from Other Clostridium Species." Applied and Environmental Microbiology 72, no. 9 (2006): 6388–93. http://dx.doi.org/10.1128/aem.02218-05.

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ABSTRACT To evaluate whether C. perfringens can be used as a model organism for studying the sporulation process in other clostridia, C. perfringens spo0A mutant IH101 was complemented with wild-type spo0A from four different Clostridium species. Wild-type spo0A from C. acetobutylicum or C. tetani, but not from C. botulinum or C. difficile, restored sporulation and enterotoxin production in IH101. The ability of spo0A from C. botulinum or C. difficile to complement the lack of spore formation in IH101 might be due, at least in part, to the low levels of spo0A transcription and Spo0A production

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Natalia, Lily. "Evaluation of antibody responses of cattle and buffaloes to Clostridium perfringens type A vaccine using ELISA." Jurnal Ilmu Ternak dan Veteriner 1, no. 3 (2014): 190–93. https://doi.org/10.14334/jitv.v1i3.33.

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An enzyme-linked immunosorbent assay (ELISA) was developed to detect specific antitoxin Clostridium perfringens type A. It was based on the use of purified alpha toxin of Clostridium perfringens type A as the coating antigen, which was then linked to specific alpha antitoxin . Horse raddish peroxidase labelled IgG was used as the conjugate, and 2,2-azino-bis (3- ethylbenzthiazoline-6-sulfonic acid) (ABTS) as the substrate . The ELISA was used to evaluate vaccination results on cattle and buffaloes against enterotoxaemia caused by Clostridium perfringens type A.

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Zheng, Mingli, Qin Li, Peichun Mao, Xiaoxia Tian, Yuxia Guo, and Lin Meng. "Identification and Correlation Analysis of Key Clostridia and LAB Species in Alfalfa Silages Prepared with Different Cultivars and Additives." Agriculture 14, no. 11 (2024): 1963. http://dx.doi.org/10.3390/agriculture14111963.

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Clostridial fermentation is the determining process causing the spoilage of direct-cut alfalfa silage, and the application of lactic acid bacteria (LAB) inoculant is considered as the most promising technology for inhibiting clostridial fermentation. In order to screen target-based LAB strains, identification and correlation analysis of key Clostridia and LAB species in alfalfa silage were conducted in this study. Three alfalfa cultivars (Sanditi, SD; Celsius, CE; SW5909, SW) were harvested at the early bloom stage and ensiled without (CK) or with LAB inoculant (LB) and sucrose (SC) for 60 d.

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Baldwin, L., A. Henderson, M. Wright, and M. Whitby. "Spontaneous Clostridium Perfringens Lung Abscess Unresponsive to Penicillin." Anaesthesia and Intensive Care 21, no. 1 (1993): 117–19. http://dx.doi.org/10.1177/0310057x9302100131.

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Clostridial necrotising pneumonia is a rare complication of aspiration, bronchial tumour or foreign body, pulmonary infarction, trauma and debilitating medical conditions. Although spontaneous clostridial pneumonia has been reported previously, close scrutiny of those case reports suggests that most of the patients had a recognised predisposing cause. We report a case of true spontaneous Clostridium perfringens pneumonia complicated by septic shock, pneumothorax and pulmonary necrosis. The patient responded poorly to conventional treatment with benzylpenicillin, and although the addition of me

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Balario, Mario, Fernanda Gonçalves, Felipe Leal, et al. "Outbreak of abomasal bloat in goat kidsdue to Clostridium ventriculi and Clostridium perfringens type A." Brazilian Journal of Veterinary Pathology 15, no. 2 (2022): 99–104. http://dx.doi.org/10.24070/bjvp.1983-0246.v15i2p99-104.

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We described an outbreak of abomasal bloat in goat kids. Increased mortality with a history of abdominal bloating, dullness, and death was reported. Postmortem exanimation revealed dehydration, pale mucosa, ascites, abomasal tympanism and intestinal meteorism and congestion, and emphysematous abomasitis. Cytological evaluation from abomasum revealed gram-positive bacteria with a cuboid shape suggestive of Clostridium ventriculi, gram-positive bacilli suggestive of Clostridium perfringens, and ovoid basophilic yeasts. C. ventriculi and C. perfringens type A were confirmed by anaerobic culture a

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Seo, Suyoung, Bokyung Son, and Minsuk Kong. "Characterization of Clostridium perfringens Phage Endolysin PlyDolk21." Antibiotics 14, no. 1 (2025): 81. https://doi.org/10.3390/antibiotics14010081.

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Background: Clostridium perfringens is a significant cause of food poisoning. Broad-spectrum antibiotics, commonly used to control C. perfringens, are becoming less effective due to the rise of antibiotic-resistant strains, necessitating alternative control strategies. Methods: A C. perfringens-infecting bacteriophage, Dolk21, and its endolysin, PlyDolk21, were isolated and characterized. The lytic activity of PlyDolk21 was assessed in comparison to its catalytic domain alone. Both PlyDolk21 and its cell wall binding domain (CBD) were evaluated in beef and milk for their antimicrobial activity

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Tontis, Achilles, and Maja Sute. "Clostridium Perfringens-Typ D." veterinär spiegel 13, no. 01 (2003): 44–47. http://dx.doi.org/10.1055/s-0029-1239396.

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Caudron, Anne, Franck Grados, Youcef Boubrit, Jean-Michel Coullet, Dominique Merrien, and Yves Domart. "Spondylodiscite à Clostridium perfringens." Revue du Rhumatisme 75, no. 3 (2008): 312–15. http://dx.doi.org/10.1016/j.rhum.2007.04.016.

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Katz, Douglas S., Erol Aksoy, and Burke A. Cunha. "Clostridium perfringens emphysematous cystitis." Urology 41, no. 5 (1993): 458–60. http://dx.doi.org/10.1016/0090-4295(93)90508-8.

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Santamaría Marín, A., C. Monroy Gómez, I. Clemente Tomé, and A. Pinardo Zabala. "Espondilodiscitis por Clostridium perfringens." Revista Clínica Española 214, no. 5 (2014): 286–87. http://dx.doi.org/10.1016/j.rce.2014.02.015.

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HOLVOET A, VERHAEGHE L, DECOCK S, ARTS J, and VAN HOOTEGEM P. "Leverabces met Clostridium perfringens." Tijdschrift voor Geneeskunde, no. 19 (2011): 948–49. http://dx.doi.org/10.47671/tvg.67.19.2001055.

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Guo, Jiang, Changqing Li, and Xuesong Gao. "Liver abscess after microwave ablation of hepatocellular carcinoma caused by Clostridium perfringens." Journal of Infection in Developing Countries 16, no. 01 (2022): 222–25. http://dx.doi.org/10.3855/jidc.13756.

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Clostridium perfringens causes pyogenic liver abscesses, which are rare but rapidly fatal infections. These abscesses often occur in patients with immunodeficiency due to malignancy, liver cirrhosis, diabetes mellitus, or organ transplantation. The identification of gram-positive bacilli in septicemia, the presence of gas-forming liver damage and intravascular hemolysis are manifestations of Clostridium perfringens infection. Clostridioides toxin A hydrolyzes phospholipids in erythrocyte membranes, causing spherocytosis and subsequent intravascular hemolysis, resulting in rapid deterioration a

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Kao, Mary J., Madhuchhanda Roy, Josephine Harter, and Ryan J. Spencer. "Uterine Sarcoma Presenting with Sepsis from Clostridium perfringens Endometritis in a Postmenopausal Woman." Case Reports in Obstetrics and Gynecology 2018 (2018): 1–5. http://dx.doi.org/10.1155/2018/8217296.

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Clostridium perfringens is an anaerobic gram positive rod that is found in normal vaginal and cervical flora in 1–10% of healthy women. Uterine infection with Clostridium perfringens is seen rarely but is often related to underlying uterine pathology and can progress quickly to sepsis. Early recognition of sepsis, prompt treatment with antibiotics, and source control with surgical management allow for optimal chance of recovery. We present a case of a postmenopausal woman who presented with sepsis, vaginal bleeding, and back pain who was found to have Clostridium perfringens infection in the s

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