Relevant bibliographies by topics / Combinatorial biosynthesis

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters

Academic literature on the topic 'Combinatorial biosynthesis'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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Journal articles on the topic "Combinatorial biosynthesis"

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Pan, Guohui, Zhengren Xu, Zhikai Guo, et al. "Discovery of the leinamycin family of natural products by mining actinobacterial genomes." Proceedings of the National Academy of Sciences 114, no. 52 (2017): E11131—E11140. http://dx.doi.org/10.1073/pnas.1716245115.

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Nature’s ability to generate diverse natural products from simple building blocks has inspired combinatorial biosynthesis. The knowledge-based approach to combinatorial biosynthesis has allowed the production of designer analogs by rational metabolic pathway engineering. While successful, structural alterations are limited, with designer analogs often produced in compromised titers. The discovery-based approach to combinatorial biosynthesis complements the knowledge-based approach by exploring the vast combinatorial biosynthesis repertoire found in Nature. Here we showcase the discovery-based
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Kolter, Thomas, Richard L. Proia, and Konrad Sandhoff. "Combinatorial Ganglioside Biosynthesis." Journal of Biological Chemistry 277, no. 29 (2002): 25859–62. http://dx.doi.org/10.1074/jbc.r200001200.

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Chen, Li, Shaofa Sun, and Gongwu Song. "Biosynthesis and Combinatorial Biosynthesis of Erythromycin." Chinese Journal of Organic Chemistry 32, no. 07 (2012): 1232. http://dx.doi.org/10.6023/cjoc1110083.

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Kadlcik, S., Z. Kamenik, D. Vasek, M. Nedved, and J. Janata. "Elucidation of salicylate attachment in celesticetin biosynthesis opens the door to create a library of more efficient hybrid lincosamide antibiotics." Chemical Science 8, no. 5 (2017): 3349–55. http://dx.doi.org/10.1039/c6sc04235j.

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Niu, Guoqing, Jiazhen Zheng, and Huarong Tan. "Biosynthesis and combinatorial biosynthesis of antifungal nucleoside antibiotics." Science China Life Sciences 60, no. 9 (2017): 939–47. http://dx.doi.org/10.1007/s11427-017-9116-0.

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Leadlay, Peter F. "Combinatorial approaches to polyketide biosynthesis." Current Opinion in Chemical Biology 1, no. 2 (1997): 162–68. http://dx.doi.org/10.1016/s1367-5931(97)80005-1.

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Menzella, Hugo G., and Christopher D. Reeves. "Combinatorial biosynthesis for drug development." Current Opinion in Microbiology 10, no. 3 (2007): 238–45. http://dx.doi.org/10.1016/j.mib.2007.05.005.

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Reeves, Christopher D. "The Enzymology of Combinatorial Biosynthesis." Critical Reviews in Biotechnology 23, no. 2 (2003): 95–147. http://dx.doi.org/10.1080/713609311.

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Piel, Jörn. "Combinatorial biosynthesis in symbiotic bacteria." Nature Chemical Biology 2, no. 12 (2006): 661–62. http://dx.doi.org/10.1038/nchembio1206-661.

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Zhang, Wenjun, and Yi Tang. "Combinatorial Biosynthesis of Natural Products." Journal of Medicinal Chemistry 51, no. 9 (2008): 2629–33. http://dx.doi.org/10.1021/jm701269v.

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Dissertations / Theses on the topic "Combinatorial biosynthesis"

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Khairudin, Khairunisa. "Biosynthetic studies and combinatorial biosynthesis of pleuromutilin antibiotics." Thesis, University of Bristol, 2018. http://hdl.handle.net/1983/46271504-0b2b-457a-92d0-073885f512cd.

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Pleuromutilin has potential as a next-generation antibiotic, and many semi-synthetic pleuromutilin derivatives have been developed. Recently, characterization of individual enzymatic steps involved in the production of pleuromutilin has been carried out. A linear pathway of pleuromutilin biosynthesis was established; however, there is a possibility of alternative or shunt pathways. Thus, the first part of this thesis aimed to investigate if any other possible routes could lead to the biosynthesis of pleuromutilin. Two alternative pathways were identified from the expression of various combinat
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Aubry, Céline. "Towards combinatorial biosynthesis of pyrrolamide antibiotics in Streptomyces." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS245.

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Depuis plus de 80 ans, le métabolisme spécialisé nous fournit de nombreuses molécules utilisées en médecine, en particulier comme anti-infectieux. Aujourd’hui, avec l’augmentation mondiale de la résistance aux antimicrobiens, de nouveaux antibiotiques sont indispensables. Une des réponses à cette pénurie grave pourrait provenir de la biologie synthétique. Dans le domaine du métabolisme spécialisé, la biologie synthétique est utilisée en particulier pour la biosynthèse de métabolites non naturels. Parmi les métabolites spécialisés, les peptides non ribosomiques constituent une cible attrayante,
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Shepherd, Micah Douglas. "COMBINATORIAL BIOSYNTHETIC DERIVATIZATION OF THE ANTITUMORAL AGENT GILVOCARCIN V." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/149.

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Gilvocarcin V (GV), the principal product of Streptomyces griseoflavus Gö 3592 and other Streptomyces spp., is the most prominent member of a distinct class of antitumor antibiotics that share a polyketide derived coumarin-based aromatic core. GV and other members of this class including polycarcin V from Streptomyces polyformus, often referred to as gilvocarcin-like aryl C-glycosides, are particularly interesting because of their potent bactericidal, virucidal and antitumor activities at low concentrations while maintaining low in vivo toxicity. Although the precise molecular mechanism of GV
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Roberts, Alexandra Anne Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Unnatural production of natural products: Heterologous expression and combinatorial biosynthesis of cyanobacterial-derived compounds." Publisher:University of New South Wales. Biotechnology & Biomolecular Sciences, 2008. http://handle.unsw.edu.au/1959.4/41533.

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Cyanobacteria produce a myriad of structurally unique secondary metabolites with useful bioactive properties. Heterologous expression of a variety of microbial natural compounds has been used to harness their diversity and facilitate their combinatorial biosynthesis. However, these genetic techniques have not been developed for secondary metabolite-producing cyanobacteria. Therefore the genetically manipulable Escherichia coli and Synechocystis sp. PCC6803 were engineered in order to develop effective heterologous hosts and promoters for the expression of cyanobacterial-derived compounds. The
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Gómez, Castellanos José Rubén. "Engineering carboxymethylproline synthases towards the biosynthetic productions of carbapenem antibiotics." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:cc8c9b07-0f3a-4dea-bd97-e2ca2e2d3a41.

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Mechanistic and biocatalytic studies of two carboxymethylproline synthases (CMPSs), CarB and ThnE, members of the crotonase superfamily of enzymes, both in isolation and in conjunction with the activity of the crotonyl-CoA carboxylase/reductase (Ccr) the malonyl-CoA synthetase (MatB) and the methylmalonyl-CoA epimerase (MCE) are presented. Protein engineering studies on carboxymethylproline synthases aimed at enabling stereoselective C–C bond formation leading to N-heterocycles via control of trisubstituted enolate intermediates were carried out. Active site substitutions, including at the oxy
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Aschenbrenner, Jennifer [Verfasser], and Michael [Gutachter] Bott. "Combinatorial Biosynthesis of Natural and Non-natural Plant-derived Phenols in Microorganisms / Jennifer Aschenbrenner ; Gutachter: Michael Bott." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/1197302077/34.

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Nybo, Stephen Eric. "ISOLATION AND ELUCIDATION OF THE CHRYSOMYCIN BIOSYNTHETIC GENE CLUSTER AND ALTERING THE GLYCOSYLATION PATTERNS OF TETRACENOMYCINS AND MITHRAMYCIN-PATHWAY MOLECULES." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/812.

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Natural products occupy a central role as the majority of currently used antibiotic and anticancer agents. Among these are type-II polyketide synthase (PKS)-derived molecules, or polyketides, which are produced by many representatives of the genus Streptomyces. Some type-II polyketides, such as the tetracyclines and the anthracycline doxorubicin, are currently employed as therapeutics. However, several polyketide molecules exhibit promising biological activity, but due to toxic side effects or solubility concerns, remain undeveloped as drugs. Gilvocarcin V (GV) (topoisomerase II inhibitor) has
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Feller, Antje Christin. "ROLE OF THE MAIZE TRANSCRIPTION FACTOR R IN THE REGULATION OF ANTHOCYANIN BIOSYNTHESIS." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1275094666.

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Vingadassalon, Audrey. "Caractérisation de voies de biosynthèse d’antibiotiques de la famille des pyrrolamides." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112064.

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Les pyrrolamides constituent une famille de produits naturels dotés de diverses activités biologiques et synthétisés par des actinobactéries. La congocidine et la distamycine, les molécules les plus connues de cette famille, sont capables de se lier à l'ADN de façon non covalente selon une certaine spécificité de séquence (succession de 4 paires de base A/T). Récemment, les gènes et la voie de biosynthèse de la congocidine ont été identifiés et caractérisés chez S. ambofaciens. Ceci a révélé un mécanisme original impliquant notamment de nouvelles enzymes et de nouvelles voies pour la biosynthè
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Brown, Steven Richard. "A design of experiments approach for engineering carbon metabolism in the yeast Saccharomyces cerevisiae." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/26158.

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The proven ability to ferment Saccharomyces cerevisiae on a large scale presents an attractive target for producing chemicals and fuels from sustainable sources. Efficient and predominant carbon flux through to ethanol is a significant engineering issue in the development of this yeast as a multi-product cell chassis used in biorefineries. In order to evaluate diversion of carbon flux away from ethanol, combinatorial deletions were investigated in genes encoding the six isozymes of alcohol dehydrogenase (ADH), which catalyse the terminal step in ethanol production. The scarless, dominant and c
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Books on the topic "Combinatorial biosynthesis"

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(Editor), W. Wohlleben, T. Spellig (Editor), and B. Müller-Tiemann (Editor), eds. Biocombinatorial Approaches for Drug Finding (Ernst Schering Research Foundation Workshop). Springer, 2005.

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Book chapters on the topic "Combinatorial biosynthesis"

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Hutchinson, C. R. "Combinatorial Biosynthesis of Antibiotics." In Drug Discovery from Nature. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-60250-4_13.

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Luzhetska, Marta, Johannes Härle, and Andreas Bechthold. "Combinatorial and Synthetic Biosynthesis in Actinomycetes." In Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, Vol. 93. Springer Vienna, 2010. http://dx.doi.org/10.1007/978-3-7091-0140-7_3.

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DeSieno, Matthew A., Carl A. Denard, and Huimin Zhao. "Drug Discovery and Development by Combinatorial Biosynthesis." In Enzyme Technologies. John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9780470627303.ch8.

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Fukushima, Ery Odette, Hikaru Seki, and Toshiya Muranaka. "Plant Cytochrome P450s in Triterpenoid Biosynthesis: Diversity and Application to Combinatorial Biosynthesis." In Fifty Years of Cytochrome P450 Research. Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54992-5_7.

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Udwary, Daniel W. "Chapter 10. Natural Product Combinatorial Biosynthesis: Promises and Realities." In RSC Biomolecular Sciences. Royal Society of Chemistry, 2009. http://dx.doi.org/10.1039/9781847559890-00299.

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Méndez, Carmen, Francisco Moris, and José A. Salas*. "Chapter 6. Biosynthesis of Indolocarbazole Alkaloids and Generation of Novel Derivatives by Combinatorial Biosynthesis." In Drug Discovery. Royal Society of Chemistry, 2012. http://dx.doi.org/10.1039/9781849734950-00099.

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Pelzer, Stefan, and Wolfgang Wohlleben. "Analysis of the Biosynthesis of Glycopeptide Antibiotics: Basis for Creating New Structures by Combinatorial Biosynthesis." In Microbial Fundamentals of Biotechnology. Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527602720.ch7.

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Baltz, Richard H. "Daptomycin and Related Lipopeptides Produced by Fermentation, Chemical Modification, and Combinatorial Biosynthesis." In Antimicrobials. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-662-45786-3_6.

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Baltz, Richard H. "Daptomycin and A54145: Structure-Activity Relationship (SAR) Studies Enabled by Combinatorial Biosynthesis." In Natural Products. John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118794623.ch23.

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Bechthold, Andreas. "Glycosylated Antibiotics: Studies on Genes Involved in Deoxysugar Formation, Modification and Attachment, and their Use in Combinatorial Biosynthesis." In Microbial Fundamentals of Biotechnology. Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527602720.ch6.

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