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Journal articles on the topic 'Combinatorial biosynthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Pan, Guohui, Zhengren Xu, Zhikai Guo, et al. "Discovery of the leinamycin family of natural products by mining actinobacterial genomes." Proceedings of the National Academy of Sciences 114, no. 52 (2017): E11131—E11140. http://dx.doi.org/10.1073/pnas.1716245115.

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Nature’s ability to generate diverse natural products from simple building blocks has inspired combinatorial biosynthesis. The knowledge-based approach to combinatorial biosynthesis has allowed the production of designer analogs by rational metabolic pathway engineering. While successful, structural alterations are limited, with designer analogs often produced in compromised titers. The discovery-based approach to combinatorial biosynthesis complements the knowledge-based approach by exploring the vast combinatorial biosynthesis repertoire found in Nature. Here we showcase the discovery-based

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2

Kolter, Thomas, Richard L. Proia, and Konrad Sandhoff. "Combinatorial Ganglioside Biosynthesis." Journal of Biological Chemistry 277, no. 29 (2002): 25859–62. http://dx.doi.org/10.1074/jbc.r200001200.

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3

Chen, Li, Shaofa Sun, and Gongwu Song. "Biosynthesis and Combinatorial Biosynthesis of Erythromycin." Chinese Journal of Organic Chemistry 32, no. 07 (2012): 1232. http://dx.doi.org/10.6023/cjoc1110083.

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4

Kadlcik, S., Z. Kamenik, D. Vasek, M. Nedved, and J. Janata. "Elucidation of salicylate attachment in celesticetin biosynthesis opens the door to create a library of more efficient hybrid lincosamide antibiotics." Chemical Science 8, no. 5 (2017): 3349–55. http://dx.doi.org/10.1039/c6sc04235j.

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5

Niu, Guoqing, Jiazhen Zheng, and Huarong Tan. "Biosynthesis and combinatorial biosynthesis of antifungal nucleoside antibiotics." Science China Life Sciences 60, no. 9 (2017): 939–47. http://dx.doi.org/10.1007/s11427-017-9116-0.

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6

Leadlay, Peter F. "Combinatorial approaches to polyketide biosynthesis." Current Opinion in Chemical Biology 1, no. 2 (1997): 162–68. http://dx.doi.org/10.1016/s1367-5931(97)80005-1.

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7

Menzella, Hugo G., and Christopher D. Reeves. "Combinatorial biosynthesis for drug development." Current Opinion in Microbiology 10, no. 3 (2007): 238–45. http://dx.doi.org/10.1016/j.mib.2007.05.005.

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8

Reeves, Christopher D. "The Enzymology of Combinatorial Biosynthesis." Critical Reviews in Biotechnology 23, no. 2 (2003): 95–147. http://dx.doi.org/10.1080/713609311.

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9

Piel, Jörn. "Combinatorial biosynthesis in symbiotic bacteria." Nature Chemical Biology 2, no. 12 (2006): 661–62. http://dx.doi.org/10.1038/nchembio1206-661.

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10

Zhang, Wenjun, and Yi Tang. "Combinatorial Biosynthesis of Natural Products." Journal of Medicinal Chemistry 51, no. 9 (2008): 2629–33. http://dx.doi.org/10.1021/jm701269v.

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11

Weissman, Kira J., and Peter F. Leadlay. "Combinatorial biosynthesis of reduced polyketides." Nature Reviews Microbiology 3, no. 12 (2005): 925–36. http://dx.doi.org/10.1038/nrmicro1287.

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12

Floss, Heinz G. "Combinatorial biosynthesis—Potential and problems." Journal of Biotechnology 124, no. 1 (2006): 242–57. http://dx.doi.org/10.1016/j.jbiotec.2005.12.001.

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13

Keller, Ullrich, and Florian Schauwecker. "Combinatorial Biosynthesis of Non-Ribosomal Peptides." Combinatorial Chemistry & High Throughput Screening 6, no. 6 (2003): 527–40. http://dx.doi.org/10.2174/138620703106298707.

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14

Shen, B. "Accessing Natural Products by Combinatorial Biosynthesis." Science Signaling 2004, no. 225 (2004): pe14. http://dx.doi.org/10.1126/stke.2252004pe14.

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15

Reynolds, K. A. "Combinatorial biosynthesis: Lesson learned from nature." Proceedings of the National Academy of Sciences 95, no. 22 (1998): 12744–46. http://dx.doi.org/10.1073/pnas.95.22.12744.

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16

Hutchinson, C. Richard. "Combinatorial biosynthesis for new drug discovery." Current Opinion in Microbiology 1, no. 3 (1998): 319–29. http://dx.doi.org/10.1016/s1369-5274(98)80036-2.

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17

Pohl, Nicola L. "Developing New Antibiotics with Combinatorial Biosynthesis." Journal of Chemical Education 77, no. 11 (2000): 1421. http://dx.doi.org/10.1021/ed077p1421.

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18

Welker, Martin, and Hans Von Döhren. "Cyanobacterial peptides — Nature's own combinatorial biosynthesis." FEMS Microbiology Reviews 30, no. 4 (2006): 530–63. http://dx.doi.org/10.1111/j.1574-6976.2006.00022.x.

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19

RUECK-BRAUN, K. "ChemInform Abstract: Combinatorial Biosynthesis of Polyketides." ChemInform 29, no. 36 (2010): no. http://dx.doi.org/10.1002/chin.199836356.

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20

Wong, Fong T., and Chaitan Khosla. "Combinatorial biosynthesis of polyketides—a perspective." Current Opinion in Chemical Biology 16, no. 1-2 (2012): 117–23. http://dx.doi.org/10.1016/j.cbpa.2012.01.018.

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21

Salas, José A., and Carmen Méndez. "Indolocarbazole antitumour compounds by combinatorial biosynthesis." Current Opinion in Chemical Biology 13, no. 2 (2009): 152–60. http://dx.doi.org/10.1016/j.cbpa.2009.02.003.

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22

Mafu, Sibongile, Meirong Jia, Jiachen Zi, et al. "Probing the promiscuity of ent-kaurene oxidases via combinatorial biosynthesis." Proceedings of the National Academy of Sciences 113, no. 9 (2016): 2526–31. http://dx.doi.org/10.1073/pnas.1512096113.

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The substrate specificity of enzymes from natural products’ metabolism is a topic of considerable interest, with potential biotechnological use implicit in the discovery of promiscuous enzymes. However, such studies are often limited by the availability of substrates and authentic standards for identification of the resulting products. Here, a modular metabolic engineering system is used in a combinatorial biosynthetic approach toward alleviating this restriction. In particular, for studies of the multiply reactive cytochrome P450, ent-kaurene oxidase (KO), which is involved in production of t

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23

Zhang, Zhuan, Hai-Xue Pan, and Gong-Li Tang. "New insights into bacterial type II polyketide biosynthesis." F1000Research 6 (February 21, 2017): 172. http://dx.doi.org/10.12688/f1000research.10466.1.

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Bacterial aromatic polyketides, exemplified by anthracyclines, angucyclines, tetracyclines, and pentangular polyphenols, are a large family of natural products with diverse structures and biological activities and are usually biosynthesized by type II polyketide synthases (PKSs). Since the starting point of biosynthesis and combinatorial biosynthesis in 1984–1985, there has been a continuous effort to investigate the biosynthetic logic of aromatic polyketides owing to the urgent need of developing promising therapeutic candidates from these compounds. Recently, significant advances in the stru

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24

Xue, Yongquan, and David H. Sherman. "Biosynthesis and Combinatorial Biosynthesis of Pikromycin-Related Macrolides in Streptomyces venezuelae." Metabolic Engineering 3, no. 1 (2001): 15–26. http://dx.doi.org/10.1006/mben.2000.0167.

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25

Staunton, James, and Barrie Wilkinson. "Combinatorial biosynthesis of polyketides and nonribosomal peptides." Current Opinion in Chemical Biology 5, no. 2 (2001): 159–64. http://dx.doi.org/10.1016/s1367-5931(00)00185-x.

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26

Staunton, James. "Combinatorial biosynthesis of erythromycin and complex polyketides." Current Opinion in Chemical Biology 2, no. 3 (1998): 339–45. http://dx.doi.org/10.1016/s1367-5931(98)80007-0.

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27

Bentley, Ronald, and J. W. Bennett. "Constructing Polyketides: From Collie to Combinatorial Biosynthesis." Annual Review of Microbiology 53, no. 1 (1999): 411–46. http://dx.doi.org/10.1146/annurev.micro.53.1.411.

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28

Walsh, Christopher T. "Combinatorial Biosynthesis of Antibiotics: Challenges and Opportunities." ChemBioChem 3, no. 2-3 (2002): 124–34. http://dx.doi.org/10.1002/1439-7633(20020301)3:2/3<124::aid-cbic124>3.0.co;2-j.

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29

LEADLAY, P. F. "ChemInform Abstract: Combinatorial Approaches to Polyketide Biosynthesis." ChemInform 29, no. 5 (2010): no. http://dx.doi.org/10.1002/chin.199805276.

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30

Moss, Nathan A., Grant Seiler, Tiago F. Leão, et al. "Nature's Combinatorial Biosynthesis Produces Vatiamides A–F." Angewandte Chemie International Edition 58, no. 27 (2019): 9027–31. http://dx.doi.org/10.1002/anie.201902571.

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31

Moss, Nathan A., Grant Seiler, Tiago F. Leão, et al. "Nature's Combinatorial Biosynthesis Produces Vatiamides A–F." Angewandte Chemie 131, no. 27 (2019): 9125–29. http://dx.doi.org/10.1002/ange.201902571.

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32

Silakowski, Barbara, Hans Ulrich Schairer, Heidi Ehret, et al. "New Lessons for Combinatorial Biosynthesis from Myxobacteria." Journal of Biological Chemistry 274, no. 52 (1999): 37391–99. http://dx.doi.org/10.1074/jbc.274.52.37391.

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33

Julsing, Mattijs K., Albert Koulman, Herman J. Woerdenbag, Wim J. Quax, and Oliver Kayser. "Combinatorial biosynthesis of medicinal plant secondary metabolites." Biomolecular Engineering 23, no. 6 (2006): 265–79. http://dx.doi.org/10.1016/j.bioeng.2006.08.001.

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34

Van Lanen, Steven G., and Ben Shen. "Progress in combinatorial biosynthesis for drug discovery." Drug Discovery Today: Technologies 3, no. 3 (2006): 285–92. http://dx.doi.org/10.1016/j.ddtec.2006.09.014.

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35

Khosla, Chaitan, and Robert J. X. Zawada. "Generation of polyketide libraries via combinatorial biosynthesis." Trends in Biotechnology 14, no. 9 (1996): 335–41. http://dx.doi.org/10.1016/0167-7799(96)10046-9.

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36

Jiang, Jinyan, Xinyang Li, Takahiro Mori, Takayoshi Awakawa, and Ikuro Abe. "Novel Cyclohexyl Meroterpenes Produced by Combinatorial Biosynthesis." Chemical and Pharmaceutical Bulletin 69, no. 5 (2021): 444–46. http://dx.doi.org/10.1248/cpb.c21-00123.

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37

Grote, Marius, Susanna Kushnir, Niclas Pryk, et al. "Identification of crucial bottlenecks in engineered polyketide biosynthesis." Organic & Biomolecular Chemistry 17, no. 26 (2019): 6374–85. http://dx.doi.org/10.1039/c9ob00831d.

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38

Han, Ah Reum, Je Won Park, Mi Kyeong Lee, et al. "Development of a Streptomyces venezuelae-Based Combinatorial Biosynthetic System for the Production of Glycosylated Derivatives of Doxorubicin and Its Biosynthetic Intermediates." Applied and Environmental Microbiology 77, no. 14 (2011): 4912–23. http://dx.doi.org/10.1128/aem.02527-10.

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ABSTRACTDoxorubicin, one of the most widely used anticancer drugs, is composed of a tetracyclic polyketide aglycone andl-daunosamine as a deoxysugar moiety, which acts as an important determinant of its biological activity. This is exemplified by the fewer side effects of semisynthetic epirubicin (4′-epi-doxorubicin). An efficient combinatorial biosynthetic system that can convert the exogenous aglycone ε-rhodomycinone into diverse glycosylated derivatives of doxorubicin or its biosynthetic intermediates, rhodomycin D and daunorubicin, was developed through the use ofStreptomyces venezuelaemut

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39

Li, Song Feng, Patrick J. Allen, Ross S. Napoli, Richard G. Browne, Hanh Pham, and Roger W. Parish. "MYB–bHLH–TTG1 Regulates Arabidopsis Seed Coat Biosynthesis Pathways Directly and Indirectly via Multiple Tiers of Transcription Factors." Plant and Cell Physiology 61, no. 5 (2020): 1005–18. http://dx.doi.org/10.1093/pcp/pcaa027.

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Abstract MYB–bHLH–WDR (MBW) transcription factor (TF) complexes regulate Arabidopsis seed coat development including mucilage and tannin biosynthesis. The R2R3 MYBs MYB5, MYB23 and TRANSPARENT TESTA2 (TT2) participate in the MBW complexes with the WD-repeat protein TRANSPARENT TESTA GLABRA1 (TTG1). These complexes regulate GLABRA2 (GL2) and TTG2 expression in developing seeds. Microarray transcriptome analysis of ttg1-1- and wild-type (Ler) developing seeds identified 246 TTG1-regulated genes, which include all known metabolic genes of the tannin biosynthetic pathway. The first detailed TTG1-d

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40

Donadio, S., and M. Sosio. "Strategies for Combinatorial Biosynthesis with Modular Polyketide Synthases." Combinatorial Chemistry & High Throughput Screening 6, no. 6 (2003): 489–500. http://dx.doi.org/10.2174/138620703106298671.

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41

Zhang, Chuanbo, Di Ke, Yuejiao Duan, and Wenyu Lu. "The Combinatorial Biosynthesis of “Unnatural” Products with Polyketides." Transactions of Tianjin University 24, no. 6 (2018): 501–12. http://dx.doi.org/10.1007/s12209-018-0151-9.

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42

Lin, Yuheng, Xinxiao Sun, Qipeng Yuan, and Yajun Yan. "Combinatorial biosynthesis of plant-specific coumarins in bacteria." Metabolic Engineering 18 (July 2013): 69–77. http://dx.doi.org/10.1016/j.ymben.2013.04.004.

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43

Rodriguez, E. "Combinatorial biosynthesis of antimicrobials and other natural products." Current Opinion in Microbiology 4, no. 5 (2001): 526–34. http://dx.doi.org/10.1016/s1369-5274(00)00246-0.

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44

Nguyen, K. T., D. Ritz, J. Q. Gu, et al. "Combinatorial biosynthesis of novel antibiotics related to daptomycin." Proceedings of the National Academy of Sciences 103, no. 46 (2006): 17462–67. http://dx.doi.org/10.1073/pnas.0608589103.

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45

Kim, Eunji, Bradley S. Moore, and Yeo Joon Yoon. "Reinvigorating natural product combinatorial biosynthesis with synthetic biology." Nature Chemical Biology 11, no. 9 (2015): 649–59. http://dx.doi.org/10.1038/nchembio.1893.

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46

Süssmuth, Roderich, Jane Müller, Hans von Döhren, and István Molnár. "Fungal cyclooligomerdepsipeptides: From classical biochemistry to combinatorial biosynthesis." Nat. Prod. Rep. 28, no. 1 (2011): 99–124. http://dx.doi.org/10.1039/c001463j.

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47

Luzhetska, Marta, Johannes Haerle, and Andreas Bechthold. "ChemInform Abstract: Combinatorial and Synthetic Biosynthesis in Actinomycetes." ChemInform 41, no. 44 (2010): no. http://dx.doi.org/10.1002/chin.201044243.

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48

Rohr, Jürgen. "Combinatorial Biosynthesis–An Approach in the Near Future?" Angewandte Chemie International Edition in English 34, no. 8 (1995): 881–85. http://dx.doi.org/10.1002/anie.199508811.

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49

Baltz, Richard H., Paul Brian, Vivian Miao, and Stephen K. Wrigley. "Combinatorial biosynthesis of lipopeptide antibiotics in Streptomyces roseosporus." Journal of Industrial Microbiology & Biotechnology 33, no. 2 (2005): 66–74. http://dx.doi.org/10.1007/s10295-005-0030-y.

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50

Sardar, Debosmita, and Eric W. Schmidt. "Combinatorial biosynthesis of RiPPs: docking with marine life." Current Opinion in Chemical Biology 31 (April 2016): 15–21. http://dx.doi.org/10.1016/j.cbpa.2015.11.016.

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