Relevant bibliographies by topics / Combretum caffrum

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Combretum caffrum'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Combretum caffrum"

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Pettit, George R., Gordon M. Cragg, and Sheo Bux Singh. "Antineoplastic Agents, 122. Constituents of Combretum caffrum." Journal of Natural Products 50, no. 3 (1987): 386–91. http://dx.doi.org/10.1021/np50051a008.

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Tripodi, Farida, Federico Dapiaggi, Fulvia Orsini, Roberto Pagliarin, Guido Sello, and Paola Coccetti. "Synthesis and biological evaluation of new 3-amino-2-azetidinone derivatives as anti-colorectal cancer agents." MedChemComm 9, no. 5 (2018): 843–52. http://dx.doi.org/10.1039/c8md00147b.

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Several synthetic combretastatin A4 (CA-4) derivatives were recently prepared to increase the drug efficacy and stability of the natural product isolated from the South African tree Combretum caffrum.
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Pettit, George R., Sheo Bux Singh, Margaret L. Niven, and Jean M. Schmidt. "Cell growth inhibitory dihydrophenanthrene and phenanthrene constituents of the african tree Combretum caffrum." Canadian Journal of Chemistry 66, no. 3 (1988): 406–13. http://dx.doi.org/10.1139/v88-071.

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Combretum caffrum, a tree in the family Combretaceae, has been found to contain three 9,10-dihydrophenanthrenes (6,7-dihydroxy-2,3,4-trimethoxy; 7-hydroxy-2,3,4,6-tetramethoxy; and 2,7-dihydroxy-3,4,6-trimethoxy) that inhibit (ED50 2.2, 2.8, and 2.6 μg/mL) growth of the murine lymphocytic leukemia cell line. One phenanthrene (7-hydroxy-2,3,4,6-tetramethoxy) was also isolated with similar (ED50 2.0 μg/mL) activity. Structures for each of these substances, including a dihydrophenanthrene (2-hydroxy-3,4,6,7-tetramethoxy-9,10-dihydrophenanthrene), were determined by detailed high resolution nuclea
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4

Lawrence, Nicholas J. "The Synthesis of (E) and (Z)-Combretastatins A-4 and a Phenanthrene from Combretum caffrum." Synthesis 1999, no. 09 (1999): 1656–60. http://dx.doi.org/10.1055/s-1999-3570.

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Pettit, George R., Sheo Bux Singh, Jean M. Schmidt, Margaret L. Nixen, Ernest Hamel, and Chii M. Lin. "Isolation, Structure, Synthesis, and Antimitotic Properties of Combretastatins B-3 and B-4 from Combretum caffrum." Journal of Natural Products 51, no. 3 (1988): 517–27. http://dx.doi.org/10.1021/np50057a011.

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Pettit, George R., Sheo Bux Singh, and Margaret L. Niven. "Antineoplastic agents. 160. Isolation and structure of combretastatin D-1: a cell growth inhibitory macrocyclic lactone from Combretum caffrum." Journal of the American Chemical Society 110, no. 25 (1988): 8539–40. http://dx.doi.org/10.1021/ja00233a037.

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7

El-Zayat, A. Atef Ebrahim, Donna Degen, Sonya Drabek, Gary M. Clark, George R. Pettit, and Daniel D. Von Hoff. "In vitro evaluation of the antineoplastic activity of combretastatin A-4, a natural product from Combretum caffrum (arid shrub)." Anti-Cancer Drugs 4, no. 1 (1993): 19–25. http://dx.doi.org/10.1097/00001813-199302000-00002.

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8

Karatoprak, Gökçe Şeker, Esra Küpeli Akkol, Yasin Genç, Hilal Bardakcı, Çiğdem Yücel, and Eduardo Sobarzo-Sánchez. "Combretastatins: An Overview of Structure, Probable Mechanisms of Action and Potential Applications." Molecules 25, no. 11 (2020): 2560. http://dx.doi.org/10.3390/molecules25112560.

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Combretastatins are a class of closely related stilbenes (combretastatins A), dihydrostilbenes (combretastatins B), phenanthrenes (combretastatins C) and macrocyclic lactones (combretastatins D) found in the bark of Combretum caffrum (Eckl. & Zeyh.) Kuntze, commonly known as the South African bush willow. Some of the compounds in this series have been shown to be among the most potent antitubulin agents known. Due to their structural simplicity many analogs have also been synthesized. Combretastatin A4 phosphate is the most frequently tested compounds in preclinical and clinical trials. It
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9

Pettit, George R., Sheo Bux Singh, Margaret L. Niven, Ernest Hamel, and Jean M. Schmidt. "Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrum." Journal of Natural Products 50, no. 1 (1987): 119–31. http://dx.doi.org/10.1021/np50049a016.

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10

Faustino, Célia, Ana P. Francisco, Vera M. S. Isca, and Noélia Duarte. "Cytotoxic Stilbenes and Derivatives as Promising Antimitotic Leads for Cancer Therapy." Current Pharmaceutical Design 24, no. 36 (2019): 4270–311. http://dx.doi.org/10.2174/1381612825666190111123959.

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The growing incidence of cancer, the toxic side-effects associated with conventional chemotherapeutic agents and the development of multidrug resistance (MDR) drive the search for novel and more effective drugs with multi-target activity and selectivity towards cancer cells. Stilbenes are a group of naturally occurring phenolic compounds of plant origin derived from the phenylpropanoid pathway that may exist as cis- or trans-isomers. Although the trans-isomer is the more common and stable configuration, resveratrol being a representative compound, cis-stilbenes are potent cytotoxic agents that
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Dissertations / Theses on the topic "Combretum caffrum"

1

Nguyen, Thi Thanh Binh. "Synthèse, évaluation biologique et vectorisation de dérivés hétérocycliques de la combretastatine A-4." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10306.

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La combretastatine A-4 (CA-4), produit naturel isolé d’un arbuste d’Afrique du sud (Combretum caffrum K.), a montré des propriétés antitumorales intéressantes. Grâce à sa capacité à empêcher la polymérisation de la tubuline, ce stilbénoïde possède des propriétés cytostatiques sélectives à l’égard de différentes lignées cellulaires cancéreuses. Certains dérivés hydrosolubles de la CA-4 comme la CA-4P (fosbretabuline) et le composé AVE8062 (ombrabuline) sont actuellement en essais cliniques pour le traitement de différents cancers. Trois séries de dérivés de la CA-4 ont été synthétisées : les Z-
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Journal articles
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