Academic literature on the topic 'Complex biomaterials'

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Journal articles on the topic "Complex biomaterials"

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Macnair, R., M. J. Underwood, and G. D. Angelini. "Biomaterials and cardiovascular devices." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 212, no. 6 (1998): 465–71. http://dx.doi.org/10.1243/0954411981534222.

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In the field of cardiovascular surgery there is presently a lack of biomaterials possessing essential characteristics of the native tissue or organ which is to be replaced. This paper describes various biomaterials that have been introduced into the circulatory system and the complex reactions that subsequently occur. The risk of infection is also discussed as well as prevention and treatment regimes that can be used. Examples of future biomaterial development are outlined in an attempt to achieve biocompatibility.
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BALTATU, Madalina Simona, Petrica VIZUREANU, Andrei Victor SANDU, Iustinian BALTATU, Doru Dumitru BURDUHOS-NERGIS, and Marcelin BENCHEA. "PROSPECTS ON TITANIUM BIOMATERIALS." European Journal of Materials Science and Engineering 8, no. 4 (2023): 201–12. http://dx.doi.org/10.36868/ejmse.2023.08.04.201.

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Biomaterials are substances that have been engineered to interact with biological systems for a medical purpose, either a therapeutic or diagnostic one. Biomaterials have a rich history of evolution, as they have continuously transformed from simple inert substances to complex, interactive materials, designed to communicate with biological systems and promote tissue regeneration and healing. Titanium, due to its excellent biocompatibility, corrosion resistance, and mechanical properties, has established its place as one of the most used biomaterials, particularly in orthopedics and dental appl
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Petković, Dušan, Miloš Madić, and Goran Radenković. "Knee Prosthesis Biomaterial Selection by Using MCDM Solver." Advanced Technologies & Materials 46, no. 2 (2021): 37–41. http://dx.doi.org/10.24867/atm-2021-2-006.

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Biomaterials are a special class of contemporary materials used to make prostheses, parts of organs or to replace entire organs. They are used to replace soft and hard tissues. Metal biomaterials are mostly used to replace hard bone tissues and joints. There is no ideal substitution for natural biological material, but each of the biomaterials has a number of advantages and disadvantages. The problem of choosing the most favorable biomaterial is a complex process of multi‐criteria decision‐making, which requires a lot of knowledge and experience. In order to help decision makers in solving thi
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Leeuwenburgh, Sander. "Self-healing biomaterials for medical applications." MATEC Web of Conferences 378 (2023): 01003. http://dx.doi.org/10.1051/matecconf/202337801003.

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Biomaterials are currently applied in increasingly complex areas such as tissue engineering, bioprinting and regenerative medicine. To this end, challenging combinations of biomaterial properties are required which usually cannot be met by conventional biomaterials. Since the early 2000s, several new concepts have been proposed to render biomaterials self-healing in order to improve the functionality of traditional biomaterials in terms of their mechanical, handling and biological properties. This presentation will provide a comprehensive overview of the field of self-healing biomaterials, ran
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Kim, Alexia, Mauricio A. Downer, Charlotte E. Berry, Caleb Valencia, Alex Z. Fazilat, and Michelle Griffin. "Investigating Immunomodulatory Biomaterials for Preventing the Foreign Body Response." Bioengineering 10, no. 12 (2023): 1411. http://dx.doi.org/10.3390/bioengineering10121411.

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Implantable biomaterials represent the forefront of regenerative medicine, providing platforms and vessels for delivering a creative range of therapeutic benefits in diverse disease contexts. However, the chronic damage resulting from implant rejection tends to outweigh the intended healing benefits, presenting a considerable challenge when implementing treatment-based biomaterials. In response to implant rejection, proinflammatory macrophages and activated fibroblasts contribute to a synergistically destructive process of uncontrolled inflammation and excessive fibrosis. Understanding the com
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Bettinger, Christopher J. "Synthesis and microfabrication of biomaterials for soft-tissue engineering." Pure and Applied Chemistry 81, no. 12 (2009): 2183–201. http://dx.doi.org/10.1351/pac-con-09-07-10.

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Biomaterials synthesis and scaffold fabrication will play an increasingly important role in the design of systems for regenerative medicine and tissue engineering. These rapidly growing fields are converging as scaffold design must begin to incorporate multidisciplinary aspects in order to effectively organize cell-seeded constructs into functional tissue. This review article examines the use of synthetic biomaterials and fabrication strategies across length scales with the ultimate goal of guiding cell function and directing tissue formation. This discussion is parsed into three subsections:
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Chow, Lesley W., and Jacob F. Fischer. "Creating biomaterials with spatially organized functionality." Experimental Biology and Medicine 241, no. 10 (2016): 1025–32. http://dx.doi.org/10.1177/1535370216648023.

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Biomaterials for tissue engineering provide scaffolds to support cells and guide tissue regeneration. Despite significant advances in biomaterials design and fabrication techniques, engineered tissue constructs remain functionally inferior to native tissues. This is largely due to the inability to recreate the complex and dynamic hierarchical organization of the extracellular matrix components, which is intimately linked to a tissue’s biological function. This review discusses current state-of-the-art strategies to control the spatial presentation of physical and biochemical cues within a biom
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Sask, Kyla N., Bruce Thong, Negar Goodarzynejad, Leslie R. Berry, and Anthony K. C. Chan. "Immunospecific analysis of in vitro and ex vivo surface-immobilized protein complex." Biointerphases 17, no. 2 (2022): 021005. http://dx.doi.org/10.1116/6.0001783.

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Biomaterials used for blood contacting devices are inherently thrombogenic. Antithrombotic agents can be used as surface modifiers on biomaterials to reduce thrombus formation on the surface and to maintain device efficacy. For quality control and to assess the effectiveness of immobilization strategies, it is necessary to quantify the surface-immobilized antithrombotic agent directly. There are limited methods that allow direct quantification on device surfaces such as catheters. In this study, an enzyme immunoassay (EIA) has been developed to measure the density of a synthetic antithrombin-h
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PRESTWICH, GLENN D., and HOWARD MATTHEW. "Hybrid, Composite, and Complex Biomaterials." Annals of the New York Academy of Sciences 961, no. 1 (2002): 106–8. http://dx.doi.org/10.1111/j.1749-6632.2002.tb03058.x.

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Agrawal, Ishita, and Piyush Dua. "Surface Modification of Advanced Biomaterials for Applications in the Pharmaceutical and Medical Fields." Biotechnology Kiosk 4, no. 3 (2022): 1–16. http://dx.doi.org/10.37756/bk.22.4.3.1.

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Lately, there has been a great deal of emphasis on developing novel biomaterials for next generation biomedical technologies. Especially, research efforts have focused on biomaterials that meet the demand for precisely engineered three-dimensional structures. These research efforts seek to design advanced biomaterials that mimic the natural environments of tissues more closely, and thus enhance the functional performance of these materials. To this end, surface modification/functionalization of biomaterials is considered pivotal to achieve the goals. Recent progress in biomaterials fabrication
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Dissertations / Theses on the topic "Complex biomaterials"

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Petay, Margaux. "Multimodal and multiscale analysis of complex biomaterials : optimization and constraints of infrared nanospectroscopy measurements." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASF092.

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Dans le domaine du biomédical, l'étude des changements physico-chimiques induits par une pathologie au sein des tissus, à l'échelle cellulaire, peut être cruciale pour élucider les mécanismes à l'origine de ce phénomène. Toutefois, seules quelques techniques d'analyse permettent une description chimique à cette échelle. La nanospectroscopie infrarouge, en particulier l'AFM-IR (Microscopie à Force Atomique-Infrarouge) est prometteuse en permettant une description chimique des matériaux à l'échelle nanométrique. Actuellement, l'AFM-IR est souvent utilisée pour l'étude des cellules et micro-organ
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Hart, Kathryn Jacoba. "A RAPID PROTOTYPING METHOD FOR CONSTRUCTING A COMPLEX THREE-DIMENSIONAL SUBSTRATE." DigitalCommons@CalPoly, 2009. https://digitalcommons.calpoly.edu/theses/217.

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Cell culturing on three-dimensional structures has increased the possibilities in tissue engineering and bioreactor research. These structures enable cells to differentiate, proliferate, mobilize, and function in a conformation that more accurately mimics in vivo conditions. Computer generated models aid in development and rapid alteration of three-dimensional cell substrates, defining their internal structure as well as their external morphology. The rapid transition from substrate design to a viable culture is imperative to quickly advance research in biomedical and tissue engineering app
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Chavez, Robert Dalton. "Development of In Vitro Tissue Engineered Blood Vessel Mimics in Complex Geometries for Coronary Stent Testing." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/828.

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Coronary heart disease is the leading cause of death in the United States and occurs when plaque occludes coronary arteries. Coronary stents, which may be used to treat coronary occlusions, are small metal tubes that are implanted in coronary arteries to restore blood flow. After stent implantation, endothelial cells grow over the stent so that blood contacts the endothelial cells instead of the stent surface; this event is known as re-endothelialization. Re-endothelialization prevents blood from clotting on the stent surface and is a good predictor of stent success. Blood vessel mimics (BVMs)
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Gangolli, Riddhi Ajit. "A Novel Biomimetic Scaffold for Guided Tissue Regeneration of the Pulp - Dentin Complex." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/409954.

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Bioengineering<br>Ph.D.<br>60 % of school children have some form of untreated tooth decay or have suffered trauma to the front teeth which results in pulp damage. If left untreated, these teeth are susceptible to premature fracture/loss under daily stresses. In cases of adolescent tooth loss, teenagers cannot get dental implants until after the growth spurts; their only option is using removable dentures which lowers their quality of life. Conventional endodontic treatment (root canal treatment) is used in cases of pulp necrosis, but cannot be performed in immature permanent teeth due to majo
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Lalevée, Gautier. "Complexes polyélectrolytes d'acide hyaluronique et de chitosane pour des applications biomédicales." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1075.

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Ce travail est consacré à l'élaboration de complexes polyélectrolytes combinant deux polyélectrolytes de charges opposées ainsi que l'étude de leur potentiel en tant que biomatériaux injectables pour du comblement de ride. L'acide hyaluronique (portant des - charges négatives sur ses groupements carboxyliques -COO ) a été complexé avec l'unique polycation d'origine naturelle appelé chitosane (portant des charges positives de + par ses groupements amines -NH3 ). Les paramètres influençant la formation et les propriétés physico-chimiques des complexes acide hyaluronique – chitosane ont été étudi
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Tirado, Viloria Patricia Carolina. "New saloplastic biomaterials based on ultracentrifuged polyelectrolyte complexes." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAF034.

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Ce travail avait pour but de développer un nouveau type de matériaux basés sur des complexes polyelectrolytes. Ces matériaux ont été obtenus par l’ultracentrifugation des complexes soit d’origine naturelle ou soit d’origine synthétique. Le système de polyélectrolytes ainsi que les conditions dans lesquelles ces matériaux peuvent être obtenus, suivi par le choix du système optimal pour des études complémentaires ont été décrits. PAA / PAH CoPECs a été choisi comme systèmes modèles de synthèse et ses propriétés physico chimiques (composition, structure et les propriétés mécaniques) ont été décri
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Lints, Martin. "Optimised Signal Processing for Nonlinear Ultrasonic Nondestructive Testing of Complex Materials and Biological Tissues." Thesis, Bourges, INSA Centre Val de Loire, 2017. http://www.theses.fr/2017ISAB0001/document.

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Nous proposons l’innovation «TR-NEWS retardée» comme une extension des méthodes TR-NEWS,issues de la symbiose du retournement temporel (RT) et des méthodes de spectroscopie d’ondes élastiques non linéaires (NEWS), avec pour principales applications le contrôle non destructif (CND) et l’imagerie ultrasonore médicale. Nous confirmons expérimentalement les bonnes performances des méthodes TR-NEWS pour : (i) des échantillons de composite CFRP aux propriétés dispersives ultrasonores autour de 10 MHz, favorisant ainsi la réverbérabilité de la propagation acoustique; (ii) des mesures de propriétés no
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BEOLCHI, RAFAEL da S. "Adicao de complexo vitaminico em duas bioceramicas e seu efeito na regeneracao ossea." reponame:Repositório Institucional do IPEN, 2009. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11529.

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Made available in DSpace on 2014-10-09T12:52:55Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:03:50Z (GMT). No. of bitstreams: 0<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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He, Tao [Verfasser], and Jörg [Akademischer Betreuer] Hausdorf. "A three-dimensional muscle biomaterial complex in vitro organoid system: An autoinduction bone formation model / Tao He ; Betreuer: Jörg Hausdorf." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1238016960/34.

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Hardy, Alexandre. "Biomatériaux fonctionnels à base de complexes de polyélectrolytes compactés de type chitosan/alginate : conception, caractérisation et premières évaluations biologiques." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF024/document.

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De nos jours, de nombreuses maladies chroniques telles que le cancer ou l’arthrose nécessitent encore de nouvelles modalités de traitement. Des biomatériaux naturels capables de véhiculer des substances actives font partie des solutions à cette problématique. Récemment, des travaux ont été menés sur un nouveau type de biomatériau, les Complexes de Polyélectrolytes Compacts (CoPEC). Dans le cadre de cette thèse, des CoPEC à base de polyélectrolytes biosourcés, le chitosan et l’alginate, fonctionnalisés avec la β-cyclodextrine (βCD) ont été formulés. Le CoPEC βCD-chitosan/alginate, non-cytotoxiq
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Books on the topic "Complex biomaterials"

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H, Linke, and Månsson Alf, eds. Controlled nanoscale motion. Springer, 2007.

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Smart Biomaterials. Springer Verlag, Japan, 2014.

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De Vito, André, and Waldyr Romão Júnior. Manipulação dos biomateriais odontológicos diretos – guia prático visual – v. 1. Universidade Nove de Julho - Uninove, 2022. http://dx.doi.org/10.5585/2022.biomateriais1.

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Nesta obra é possível justificar a manipulação com base nas propriedades dos materiais. Os profissionais poderão compreender o porquê de a manipulação ideal acontecer de uma ou outra forma. Sob esse ponto de vista, este livro e inédito. Em nenhum outro a relação entre a teoria e a prática ficou tão bem estabelecida. Associamos ao texto um guia prático ilustrado que demonstra o passo a passo da manipulação de cada um dos biomateriais mais utilizados durante a rotina clínica. Portanto, será possível associar a teoria com a prática com o objetivo de instruir os profissionais da odontologia de for
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Book chapters on the topic "Complex biomaterials"

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Zhai, Xinyun, and Wenguang Liu. "Chapter 13. 3D-bioprinting for Engineering Complex Tissues and Vascularization." In Biomaterials Science Series. Royal Society of Chemistry, 2021. http://dx.doi.org/10.1039/9781839163975-00339.

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Jang, Woo Dong, Nobuhiro Nishiyama, and Kazunori Kataoka. "Preparation of Naphthalocyanine Dendrimer Loaded Polyion Complex Micelle for Photodynamic Therapy." In Advanced Biomaterials VII. Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.465.

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Li, Quan Li, Zhi Qing Chen, Guo Min Ou, et al. "Biomimetic Synthesis of Apatite - Polyelectrolyte Complex (Chitosan - Phosphorylated Chitosan) Hydrogel as an Osteoblast Carrier." In Advanced Biomaterials VI. Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-967-9.75.

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Lee, Hyun Jung, Keun Hong Park, So Ra Park, and Byoung Hyun Min. "Chitosan/Heparin Polyelectrolyte Complex Nanoparticles (100~200nm) Covalently Bonded with PEI for Enhancement of Chondrogenic Phenotype." In Advanced Biomaterials VII. Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.329.

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Kim, Sung Won, Yun Sik Nam, Yeon Jin Min, et al. "Release Profile of a Model Protein Drug Depending on the Stability of Microspheres Based on Polyelectrolyte Complex." In Advanced Biomaterials VII. Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.505.

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Katsaras, J., T. A. Harroun, M. P. Nieh, M. Chakrapani, M. J. Watson, and V. A. Raghunathan. "Neutron Scattering from Biomaterials in Complex Sample Environments." In Neutron Scattering in Biology. Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/3-540-29111-3_7.

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Ganapathy, Hullathy Subban, Min Hee Woo, Yeong Soon Gal, and Kwon Taek Lim. "Inclusion Complex Formation of Water- Soluble Drug, Captopril, and Peracetylated-β-Cyclodextrin in Supercritical CO2 for Controlled Release Applications." In Advanced Biomaterials VII. Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.489.

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Tilocca, Antonio. "Molecular Dynamics Methods for Modeling Complex Interactions in Biomaterials." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-388-2_18.

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López, Hugo F., Armando Saldívar, and P. Huang. "Development and Properties of ε-Martensite in Co-Cr-Mo Alloys for Biomaterials Applications." In Properties of Complex Inorganic Solids 2. Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-1205-9_23.

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Song, Xia, and Jun Li. "Recent Advances in Polymer-Cyclodextrin Inclusion Complex-Based Supramolecular Hydrogel for Biomedical Applications." In Springer Series in Biomaterials Science and Engineering. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-57511-6_7.

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Conference papers on the topic "Complex biomaterials"

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Karyasa, I. Wayan, and Enike Dwi Kusumawati. "Strategy for Developing Medical Inorganic-Organic Hybrid Biomaterials through the Improvement of Sericulture as a Producer of Renewable Active Biological Raw Materials." In 8th International Conference on Advanced Material for Better Future. Trans Tech Publications Ltd, 2025. https://doi.org/10.4028/p-yox7jx.

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The need for biomaterials is increasing as more and more health problems become more and more complex. Progress in the field of medical biomaterials is also accelerating, but the provision of renewable biomaterials continues to be of concern to the world as awareness of sustainable development in the field of chemistry and health. Various strategies in the development of medical biomaterials were studied through a narrative review of the literature. One of them is the strategy of developing inorganic-organic hybrid medical biomaterials through the cultivation of silkworms as producers of renew
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Bhatia, Sangeeta N., Martin L. Yarmush, and Mehmet Toner. "Engineered Substrates for Controlling Cell-Cell Interactions." In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-1319.

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Abstract Biomaterials have been previously engineered to serve a variety of different functions: precise degradation in vivo (Kimura, 1993), modulation of cell physiology via binding to specific ligands (Hubbell et al, 1992), and selective permeability of certain solutes (Lysaght et al, 1994). However, in complex tissues, where cell-cell interactions strongly influence tissue function, biomaterials which modulate this fundamental parameter have not been available. In this study, we describe a technique which allows control over cell-cell interactions by using semiconductor-based microfabricati
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Púa, Lizeth Gutiérrez, Virginia Paredes Méndez, Ana María Fonseca Reyes, Juan Carlos Rincón Montenegro, and Lily Margareth Payares. "Enhanced Corrosion Resistance and Biocompatibility of Pure Magnesium Modified by Calcium Phosphate / Biomass of Chlorella Sp. Coating for Orthopedic Applications." In CONFERENCE 2022. AMPP, 2022. https://doi.org/10.5006/c2022-18513.

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Extended Abstract Biomedical metallic materials can be harmful to the human body in the long term due to the release and accumulation of metallic particles resulting from the degradation and corrosion of the material, a consequence of the wear suffered by the implant. Therefore, biodegradable materials have been studied that reduce the risk to health and the need for a second surgical intervention to remove the implant when the tissue is regenerated. Magnesium alloys are possible candidates as degradable biomaterials for temporary implants in various specialties such as traumatology, cardiolog
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Mahmoud, Rahmatul, Quang Nguyen, Gordon Christopher, and Paul F. Egan. "3D Printed Food Design and Fabrication Approach for Manufacturability, Rheology, and Nutrition Trade-Offs." In ASME 2021 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/detc2021-70663.

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Abstract 3D printing enables the production of personalized designs that are desirable in the medical industry for applications including orthopedics, tissue engineering, and personalized nutrition. Currently, the design process relies on trial-and-error approaches, especially for biomaterial development, and there is a need for methodologies to streamline the design process to facilitate automation. Here, we investigate a design methodology for printing foods by mixing novel biomaterial combinations informed by rheological measurements that indicate printability. The process consists of first
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Narag, Jadze P. C., Nayere Taebnia, Rujing Zhang, Thomas L. Andresen, Niels B. Larsen, and Emil B. Kromann. "Imaging complex organ-on-chip systems." In Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V, edited by Pietro Ferraro, Monika Ritsch-Marte, Simonetta Grilli, and Christoph K. Hitzenberger. SPIE, 2021. http://dx.doi.org/10.1117/12.2593200.

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Narag, Jadze P. C., Nayere Taebnia, Rujing Zhang, Thomas L. Andresen, Niels B. Larsen, and Emil B. Kromann. "Imaging complex organ-on-chip systems." In Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V, edited by Pietro Ferraro, Monika Ritsch-Marte, Simonetta Grilli, and Christoph K. Hitzenberger. SPIE, 2021. http://dx.doi.org/10.1117/12.2593243.

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Kawabe, Yutaka, Yuki Suzuki, Kento Okoshi, and Takuya Tanaka. "Induced circular dichroism and laser action of hemicyanine dyes coupled to DNA and DNA-complex." In Optical Materials and Biomaterials in Security and Defence Systems Technology, edited by Roberto Zamboni, François Kajzar, Attila A. Szep, and Katarzyna Matczyszyn. SPIE, 2017. http://dx.doi.org/10.1117/12.2277394.

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Kawabe, Yutaka, and Kento Okoshi. "Light amplification and photo-isomerization characteristics of laser dyes and azo molecules incorporated into DNA-complex systems." In Optical Materials and Biomaterials in Security and Defence Systems Technology, edited by Roberto Zamboni, François Kajzar, Attila A. Szep, and Katarzyna Matczyszyn. SPIE, 2018. http://dx.doi.org/10.1117/12.2325290.

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Fee, Timothy J., and Joel L. Berry. "Mechanics of Electrospun Polycaprolactone Nanofibers." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80297.

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Electrospun biomaterials are gaining popularity as scaffolding for engineered tissues. This fibrous scaffolding of natural or synthetic polymers can mimic properties of the natural extra-cellular matrix. Moreover, undifferentiated cells seeded onto and within an electrospun matrix may be directed to differentiate into a desired tissue type through the application of the appropriate biochemical and mechanical conditions. It is becoming clear that the mechanical deformation of any electrospun matrix plays an important role in cell signaling. However, electrospun biomaterials have inherently comp
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Ghosh, Soham, J. Craig Dutton, and Bumsoo Han. "Spatiotemporal Intracellular Deformation of Cells During Freezing-Induced Cell-Fluid-Matrix Interactions." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14673.

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Freezing of biomaterials is emerging as one of the key biotechnologies in cell/tissue engineering, medicine and biology. Its applications include — 1) preservation of cell/tissue engineering products, 2) quality control of biospecimens cryopreserved in tissue banks and repositories, and 3) synthesis procedures of biomaterials such as decellularization of native tissues to create acellular (i.e., cell-free) complex three-dimensional extracellular matrices (ECMs). Traditionally, research efforts have focused on determining optimal freeze/thaw (F/T) protocols with chemical additives, so called cr
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