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Dissertations / Theses on the topic 'Corneal keratoconus'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Parkin, Ben. "The role of matrix metalloproteinase-2 and its inhibitors in keratoconus." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343282.

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2

Mannion, Maria Luisa Simó. "Corneal nerve morphology and function in keratoconus." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493938.

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Keratoconus is a bilateral non-inflammatory corneal ectatic disorder characterised by corneal thinning which leads to distortion and progressive impairmient of vision. There are still many unanswered questions relating to its aetiology, clinical course and the factors affecting its progression. Increased visibility of the corneal nerves appears to be an early sign of the disease and there are reports of reduced corneal sensitivity in keratoconic patients. Early detection of keratoconus is of increasing importance, especially in refractive surgery to avoid the possibility of inducing iatrogenic

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3

Colling, Amber J. "A comparison of three methods of measuring central corneal thickness in normal and thinned corneas." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1275058650.

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4

Tang, Maolong. "Corneal mean curvature mapping application in laser refractive surgery /." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1094593446.

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5

Ferdi, Alexander Charles. "Developing technology to improve health outcomes in corneal disease." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27407.

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Background Modern keratoconus monitoring and management centres around tomography. Large scale studies that inform practice on the natural history of keratoconus were carried out in the 1990s and predate tomography. Natural history studies using tomography are needed to effectively inform current clinical practice. Corneal cross-linking (CXL) is the only treatment that can stabilise keratoconus progression. High quality randomised controlled trials (RCTs) of CXL have been carried out but large scale real-world studies are needed, to provide further evidence of outcomes and safety. Regist

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6

Beshtawi, Ithar. "The structural and functional effects of corneal collagen cross-linking on human corneal tissue." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-structural-and-functional-effects-of-corneal-collagen-crosslinking-on-human-corneal-tissue(12f210fe-82b6-4855-a3ea-c5abd828642d).html.

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The aim of this project was to analyse the cellular and biomechanical changes after collagen cross-linking (CXL) treatment on postmortem eye-banked human corneas using different UVA intensities and repeated treatments, and to explore the effects of standard collagen cross-linking on keratoconic corneal buttons, in-vitro. Preliminary studies were conducted to assess the feasibility of using eye-banked corneas to assess the effects of collagen cross-linking, and the possibility of applying scanning acoustic microscopy (SAM) to measure the speed of sound/elasticity of corneal tissue. Eye-banked h

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7

Giacomin, Natalia Torres. "Análise da eficácia e segurança do crosslinking corneano em pacientes com ceratocone avançado." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-09042018-100655/.

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OBEJTIVOS: Analisar a segurança e eficácia da cirurgia de crosslinking (CXL) de córnea em pacientes com ceratocone em estágios avançados após um seguimento de 4 anos. MÉTODOS: Trata-se de um estudo retrospectivo de pacientes com ceratocone avançado em progressão (Estágio 3 e 4 da classificação de Amsler-Krumeich) que foram submetidos a cirurgia de CXL seguindo o protocolo padrão. Os parâmetros examinados foram acuidade visual com (AVCC) e sem (AVSC) correção, valores ceratométricos (média, plana, curva e apical), paquimetria, e contagem de células endoteliais no préoperatório e após 12, 24 e 4

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8

Haque, Sameena. "In Vivo Imaging of Corneal Conditions using Optical Coherence Tomography." Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/2976.

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Purposes: To use optical coherence tomography (OCT) to image and quantify the effect of various corneal conditions, in terms of corneal, stromal and epithelial thickness, and light backscatter. To assess the changes caused by overnight orthokeratology (Corneal Refractive Therapy; CRT<sup>TM</sup>) lens wear, keratoconus and laser in-situ keratomileusis (LASIK) refractive surgery, each of which may lead to topographical alterations in corneal thickness either by temporary moulding, degeneration, or permanent laser ablation, respectively. <br /><br /> Methods: Topographical thickness of

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9

Väisänen, T. (Timo). "Cellular localisation of type XIII collagen, and its induced expression in human neoplasias and corneal diseases." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514279107.

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Abstract Type XIII collagen belongs to the group of transmembrane collagens. In this thesis the plasma membrane localisation and function of type XIII collagen have been studied using cell biological methods. Type XIII collagen was found to reside in focal adhesions. It appeared in these structures at a very early stage of their assembly and disappeared from them concurrently with focal adhesion proteins talin and vinculin. Insect cells expressing type XIII collagen showed an enhanced adhesion to certain matrix components. These localisation and adhesion data suggested that the function of ty

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10

Motta, Lorenzo. "Confronto dei risultati visivi e topografici in pazienti con cheratocono sottoposti a cross-linking corneale: tecnica tradizionale Vs transepiteliale." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1006.

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ABSTRACT Obiettivo. Confronto dei risultati visivi e topografici in pazienti con cheratocono in evoluzione, sottoposti a cross-linking corneale (CCL) con procedura epi-off ed epi-on. Materiali e metodi. 72 pazienti; 36 tecnica standard e 36 tecnica transepiteliale, da gennaio 2010 a luglio 2011. Pachimetria > 400 ìm. Follow-up dopo trattamento (1,3 e 6 mesi) eseguito con: visus naturale e corretto, refrazione, biomicroscopia alla lampada a fessura, topografia corneale. Risultati. 36 trattati con CCL standard dopo 6 mesi si dimostra riduzione del Kmax di 2 D e aumento visus di 3/10. Complicanze

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11

Wilson, Abby. "An investigation into the use of Laser Speckle Interferometry for the analysis of corneal deformation with relation to biomechanics." Thesis, Loughborough University, 2017. https://dspace.lboro.ac.uk/2134/28380.

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There has been widespread interest in corneal biomechanics over recent years, driven largely by the advancements in, and the popularity of refractive surgery techniques and subsequent concerns over their safety. Lately there has been interest into whether crosslinking, which is currently used for the treatment of keratoconus, could be developed as a minimally invasive technique to change the refractive power of the cornea by selectively changing the corneal biomechanics in specific regions to induce a shape change. Successful application of this technique requires a detailed understanding of c

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12

Lima, Mário Henrique Camargos de. "Avaliação da função visual de pacientes submetidos a transplante de córnea lamelar anterior profundo utilizando dissecção com fio." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-05012016-154155/.

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Objetivo: Avaliar a função visual de pacientes submetidos a transplante lamelar anterior profundo (DALK) utilizando a dissecção com tunelizador manual e fio. Métodos: Foram incluídos 33 pacientes com ceratocone que apresentavam BCVA <= 0,60 LogMar, miopia e astigmatismo entre 8,00 e 10,00D, K central médio > 53,00D, ausência de cicatrizes, espessura corneana mínima entre 300 e 400 um. Foi feita avaliação oftalmológica completa no pré e no pós-operatório de 6 a 8 meses. Estas avaliações foram complementadas com exame topográfico da córnea, microscopia especular para avaliação da densidade das c

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Ribeiro, Guilherme Barreto de Oliveira. "Uso da transformada de Wavelet e técnicas de aprendizado de máquina para criação de modelo computacional de auxílio ao diagnóstico de ceratocone baseado em parâmetros biomecânicos da córnea." Universidade Federal de Alagoas, 2015. http://www.repositorio.ufal.br/handle/riufal/1605.

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This study aimed to create computer models to aid the diagnosis of keratoconus using an edge segmentation algorithm, wavelet transforms and machine-learning techniques based on biomechanical parameters of the cornea derived from Corvis ST. 102 normal eyes, and 73 eyes with keratoconus grade I and II for training and validation of the models were included. Initially the 31 original equipment parameters were studied to assess its power in separating the control groups and research group. Then, it was used the Canny algorithm for edges segmentation of the selected images, so that 400 central poin

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Lappin, Cory James. "Investigating the Role of Shroom3 in Collagen Regulation and Development of the Corneal Stroma." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523921114811659.

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SILVA, Rodrigo Salustiano Corrêa e. "Análise endotelial da córnea em pacientes submetidos à cirurgia corneal pela técnica de anel intraestromal." Universidade Federal de Goiás, 2012. http://repositorio.bc.ufg.br/tede/handle/tde/1546.

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Made available in DSpace on 2014-07-29T15:25:21Z (GMT). No. of bitstreams: 1 tesedefendidarodrigo.pdf: 1424160 bytes, checksum: ba481cb9361d272aa1bf192493e601ce (MD5) Previous issue date: 2012-06-12<br>To evaluate corneal endothelium by means of specular microscopy exam in patients with keratoconus, before and after Cornealring® corneal intrastromal ring surgery. A hundred and two eyes of sixty-seven patients, aged between 12 and 45, with the average age of 27,31 ± 8,15 years, 30 of whom females and 37 males, were selected to be submitted to the implant of Cornealring® corneal ring segments

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Renesto, Adimara da Candelaria [UNIFESP]. "Efeito da riboflavina tópica exposta à irradiação ultravioleta A e inserção de segmentos de anéis corneanos intraestromais para ceratocone." Universidade Federal de São Paulo (UNIFESP), 2012. http://repositorio.unifesp.br/handle/11600/9359.

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Made available in DSpace on 2015-07-22T20:49:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-05-30. Added 1 bitstream(s) on 2015-08-11T03:26:18Z : No. of bitstreams: 1 Publico-13221.pdf: 17673997 bytes, checksum: 5eccd3ef771fd6553a1cc32756fcef7a (MD5)<br>Objetivos: 1) Avaliar se o cross-linking do colágeno corneano antes da inserção de segmentos de anéis corneanos intraestromais altera o tratamento do ceratocone. 2) Avaliar se o cross-linking do colágeno corneano modifica as características citológicas da superfície ocular em portadores de ceratocone. Métodos: Trinta e nove olhos

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17

Hoh, Hon Bing. "Biochemistry of keratoconus." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266879.

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Dantas, Paulo Elias Corrêa. "Alterações topográficas da córnea em pacientes com cérato-conjuntivite vernal." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-07032002-002915/.

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Doença alérgica ocular acomete cerca de ¼ da população mundial. Dentro do espectro da doença alérgica ocular, a cérato-conjuntivite vernal, que afeta principalmente crianças, pode apresentar-se sob forma severa e persistente, levando a dano do tecido corneal e comprometimento da função visual. Traumatismo epitelial crônico, induzido pelo ato de coçar os olhos, associado ao intenso prurido ocular tem sido apontado como fator de risco importante na patogênese do ceratocone. Pode estimular a apoptose prematura dos ceratócitos, provocando mudanças estruturais do estroma da córnea. A associação de

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Souza, Murilo Barreto. "Rede de aprendizado supervisionado como método de auxilio na detecção do ceratocone." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-27072011-172605/.

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INTRODUÇÃO: O ceratocone é uma doença não inflamatória, sem etiologia definida, caracterizada pelo afilamento estromal e protrusão da córnea. Geralmente esta doença torna-se clinicamente evidente na adolescência. Apesar de possuir sinais clínicos bem conhecidos, a detecção do ceratocone em estádios iniciais pode representar uma tarefa de difícil execução, mesmo quando a videoceratografia computadorizada ou outros métodos são utilizados para avaliar a córnea. Anteriormente, diagnosticar o ceratocone apenas após a identificação de sinais clínicos inequívocos era uma conduta aceitável. Com o adve

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20

Lupasco, Tatiana. "Etude comparative du programme de différenciation terminale de l'épithélium de la cornée normale et des patients atteints de kératocône." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30011.

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L'épithélium cornéen, tout comme l'épiderme, forme une barrière complexe qui protège l'organisme contre les agressions de l'environnement. Dans l'épiderme, cette fonction est assurée en grande partie par la couche cornée qui correspond à l'étape finale, de mieux en mieux caractérisée, de la différenciation du kératinocyte. Par contre, le programme de différenciation de l'épithélium de la cornée est peu étudié. Pourtant, les premières manifestations de diverses pathologies cornéennes apparaissent au niveau de l'épithélium, et leur dépistage précoce pourrait modifier notablement leur prise en ch

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Touboul, David. "Apport de l’élastographie par imagerie des ondes de cisaillement pour l’évaluation de la photo-polymerisation du collagène cornéen." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0051/document.

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Le cross-linking du collagène cornéen (CXL) est une cornéoplastie mini-invasive reposant surun concept biomécanique difficile à objectiver physiquement et dont les preuves del’efficacité thérapeutique sont d’interprétation complexe. Les principes, les nuances et lesrésultats du CXL sont colligés dans cette thèse afin de valider l’intérêt du modèleexpérimental choisi pour tester la pertinence de notre travail de recherche sur l’élastographiecornéenne par ondes de cisaillement.Notre cheminement expérimental a abouti au choix du modèle de CXL trans-épithélial (TCXL)assisté par iontophorèse (I-CXL

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Assiri, Abdullah A. M. "A clinical and ultrastructural investigation of the cornea in keratoconus." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/55421/.

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Keratoconus is a non-inflammatory corneal disease that progressively causes topographical alteration of the cornea as a result of thinning, and consequently leads to impaired vision. In this thesis, the clinical studies are showed that the incidence rate and severity of keratoconus in Asir province, Saudi Arabia is high with an early onset and more rapid progress to the severe disease stage at a young age compared to other countries. The result also showed that the disease required different contact lens designs to be available in the clinics and the selection of initial back optic zone radius

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Bleshoy, Hans. "Neuropathology and sensitivity in the keratoconic cornea." Thesis, City University London, 1990. http://openaccess.city.ac.uk/7670/.

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Corneal touch threshold (CTT) was investigated by aesthesiometry in patients with keratoconusq with and without contact lens wear. Using a matching control group it was established that CTT was significantly higher for the central corneal position in keratoconus. No difference inCTT was found in four peripheral corneal positions in keratoconic and normal corneas. Central CTT correlated inversely with central corneal curvature and central corneal thickness. Central corneal curvature was the most significant single factor to correlate with central CTT and indicates that CTT increases (sensitivit

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Wan, Abdul Halim Wan Haslina. "Tonometry agreement and corneal biomechanical features in normal, glaucomatous and keratoconic eyes." Thesis, Aston University, 2017. http://publications.aston.ac.uk/31760/.

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Intraocular pressure measurement is a routine clinical examination performed in ophthalmic practice. It is vital in clinical monitoring, diagnosis and management of certain eye diseases. There are many types of tonometers currently available to measure the intraocular pressure (IOP). These tonometers employ different technologies compared to the standard Goldman applanation tonometer (GAT). Studies often report inter-tonometry agreement and bias of new tonometers against GAT. However, only a minority have studied the proportionate bias and factors that influence the inter-tonometry bias of a n

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Delic, Naomi Christina. "The effects of ultraviolet radiation on the repair and maintenance of the cornea." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20951.

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Epidemiological studies have implicated UVR as a causative agent in a variety of ocular diseases. Keratoconus is the bulging of the cornea due to it becoming thinner, leading to poor vision. Although UVR has recently been identified as a likely contributing factor, the pathogenic mechanisms remain to be elucidated. This thesis aims to provide a model of keratoconus and subsequently study the components of corneal maintenance in response to UVR. The corneas of mice were chronically exposed to physiologically relevant doses of UVR, and studied in vivo using a slit lamp and ex vivo histopatholo

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Porter, Louise. "Brittle cornea syndrome : molecular characterisation of a multisystem disorder." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/brittle-cornea-syndrome-molecular-characterisation-of-a-multisystem-disorder(6a34fd5d-14ac-40cc-9206-1caf06c9ef51).html.

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Brittle cornea syndrome (BCS) is an autosomal recessive, multisystemic connective tissue disorder characterised by extreme corneal thinning and fragility. Mutations in transcription factors ZNF469 and PRDM5 cause BCS types 1 and 2, respectively. Both genes are believed to regulate the transcription of extracellular matrix (ECM) components, particularly fibrillar collagens, and are suggested to act on a common pathway. Molecular diagnosis is available for affected patients, and those at risk of being heterozygous carriers. Chapter 3 presents the identification of mutations in ZNF469 in 14 famil

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Buccoliero, Donato. "Risultati funzionali e studio con microscopia confocale in pazienti sottoposti a Cross linking corneale transepiteliale." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1007.

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Pereira, Fernando Ramon Ayres. "Sistemas de emissão UV-A homogêneo para uso clínico de irradiação de córneas." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/18/18152/tde-09122010-091052/.

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Este trabalho é parte de um projeto destinado a criar um equipamento médico, para ser aplicado com o protocolo de crosslinking de colágeno corneano, para o tratamento do ceratocone, do qual resultou o desenvolvimento de um sistema de irradiação UV-A de córneas para a aplicação clínica oftalmológica. O sistema desenvolvido neste trabalho consiste de um circuito de malha fechada, que estabiliza a potência luminosa emitida (com erro global, após a calibração, menor que 20% durante a emissão), possibilita seu ajuste até 5 mW (6,366 mW/\'CM POT. 2\') e permite selecionar a duração da emissão entre

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Glass, Dianne Henry. "CHARACTERIZATION OF THE BIOMECHANICAL PROPERTIES OF THE IN VIVO HUMAN CORNEA." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1211920104.

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White, Cassandra L. "Fluorescein Photography and the Evaluation of Cornea-to-Contact Lens Patterns in Patients with Different Severity Levels of Keratoconus." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243192435.

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Hayes, Sally. "Structural organisation of collagen in the corneas of primates and other mammals and the stromal changes associated with the disease keratoconus." Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/56112/.

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X-ray diffraction was used to determine the ultrastructural arrangement of collagen in the normal human, monkey and bovine cornea. Using the same technique, the ultrastructural organisation of collagen in human keratoconus corneal buttons and in the corneas of mice with a murine specific keratopathy (SKC), in which the males develop a cone shaped cornea, was also examined. Collagen fibrils were found to be most closely packed in the prepupillary region of the normal human cornea, suggesting an optimisation of tissue strength and transparency in the main optical zone. In humans and marmoset mon

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Rodrigues, Francisco Weliton. "Polimorfismo genético em pacientes portadores de ceratocone." Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/7065.

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Byström, Berit. "Laminins and alpha11 integrin in the human eye : importance in development and disease." Doctoral thesis, Umeå universitet, Oftalmiatrik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1950.

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The extracellular matrix (ECM) offers a protective shelter for cells and provides signaling paths important for cell to cell communication. ECM consists of basement membranes (BM) and interstitial matrix. BMs provide mechanical support for parenchymal cells, influence cell proliferation, survival, migration and differentiation. They are also important for tissue integrity. Laminins (LM) are the major non-collagenous component of BMs. Cell-ECM interactions, mediated by receptors, are indispensable during embryonic development, wound healing, remodeling and homeostasis of tissues. The integrins

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Reis, Leonardo Mariano. "Análise da ocorrência de polimorfismo de nucleotídeo único do gene DOCK9 em ceratocone." Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/5654.

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Sandrin, Leda das Neves Almeida. "Características clínicas e imunológicas de pacientes com ceratocone e alergia ocular: um estudo transversal com ênfase na análise da inflamação da superfície ocular." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-07032017-150155/.

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Objetivo: Comparar as características inflamatórias da superfície ocular de pacientes com ceratocone (CE) às de pacientes com alergia ocular (AO). Métodos: Realizou-se um estudo transversal, envolvendo 134 participantes, divididos em três grupos: alergia ocular (AO)(n=55), ceratocone com ou sem alergia ocular associada (CE) (n=61) e controle (CO) (n=18). Os participantes do estudo foram recrutados e avaliados em clínica privada na cidade de Chapecó-SC, no período de polinização, em dezembro de 2013 e de outubro de 2014 a janeiro de 2015. Para análise dos grupos, todos os pacientes foram avalia

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Coutinho, Ricardo Filipe Moço. "Management of keratoconus with intrastromal corneal ring segments." Master's thesis, 2016. https://repositorio-aberto.up.pt/handle/10216/88642.

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Coutinho, Ricardo Filipe Moço. "Management of keratoconus with intrastromal corneal ring segments." Dissertação, 2016. https://repositorio-aberto.up.pt/handle/10216/88642.

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Litke, Anastasia Marie. "Investigating the pathogenicity of missense mutations in VSX1 and their association with corneal dystrophies." Thesis, 2018. https://dspace.library.uvic.ca//handle/1828/9342.

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Two corneal dystrophies, posterior polymorphous corneal dystrophy (PPCD) and keratoconus, have been associated with missense mutations found in the transcription factor-encoding gene Visual System Homeobox 1 (VSX1). Despite this association, the pathogenic link between VSX1 and these diseases remains controversial. To address this issue, I utilized a variety of in vitro approaches to study how seven VSX1 missense mutations found in disease populations that span two highly conserved domains, the homeodomain (HD) and CVC domain affect VSX1 transcriptional activity, protein expression levels and

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Rowjee, Taruna. "A retrospective analysis of the outcomes in visual acuity and keratometry readings after corneal collagen crosslinking in keratoconus." Thesis, 2017. http://hdl.handle.net/10539/23205.

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A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, in the fulfillment of the requirements for the degree of Master of Medicine in Ophthalmology. Johannesburg, February 2017<br>Purpose: To evaluate if corneal collagen crosslinking carried out on patients with keratoconus, slows down or halts the progression of keratoconus. To determine which group of keratoconus patients benefited most from the procedure. Methods: A retrospective record review of 41 eyes of 29 patients. Visual acuity and keratometry measurements were recorded for the involved eye pre-

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Sylvestre, Daniel Joseph. "Optimizing riboflavin/ultraviolet-a corneal collagen cross-linking for the treatment of progressive keratoconus." Thesis, 2017. https://hdl.handle.net/2144/23839.

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Patients with keratoconus exhibit a biomechanically weakened cornea which loses its proper shape and thereby loses its refractive power. It is usually progressive, beginning with poor visual acuity and eventually necessitating corneal transplant. The cause is likely multifactorial, but involves the weakening of the collagen structure of the corneal stroma, resulting in characteristic thinning and conical distortion. Collagen cross-linking is the first treatment to demonstrate efficacy in halting the progression of the disease. UVA radiation is used to activate riboflavin and photochemically in

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Natal, Miguel Pereira Correia. "Transepithelial accelerated corneal collagen crosslinking in patients with progressive keratoconus: long term follow up results." Master's thesis, 2021. https://hdl.handle.net/10216/134509.

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Objetivo: avaliar de forma sistematizada a eficácia a longo prazo do crosslinking de colagénio corneano transepitelial acelerado (TE-ACXL) no tratamento de olhos com queratocone progressivo, reportando os seus outcomes visuais e morfológicos ao longo de um follow-up de 4 anos. Métodos: olhos de pacientes submetidos a TE-ACXL (6mW/cm2 durante 15 minutos) para queratocone progressivo foram incluídos neste estudo de coorte retrospetivo. Melhor acuidade visual corrigida (BCVA), valores queratométricos, paquimetria corneana mínima (PachyMin) e índices topográficos foram analisados pré-operatoriamen

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Natal, Miguel Pereira Correia. "Transepithelial accelerated corneal collagen crosslinking in patients with progressive keratoconus: long term follow up results." Dissertação, 2021. https://hdl.handle.net/10216/134509.

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Objetivo: avaliar de forma sistematizada a eficácia a longo prazo do crosslinking de colagénio corneano transepitelial acelerado (TE-ACXL) no tratamento de olhos com queratocone progressivo, reportando os seus outcomes visuais e morfológicos ao longo de um follow-up de 4 anos. Métodos: olhos de pacientes submetidos a TE-ACXL (6mW/cm2 durante 15 minutos) para queratocone progressivo foram incluídos neste estudo de coorte retrospetivo. Melhor acuidade visual corrigida (BCVA), valores queratométricos, paquimetria corneana mínima (PachyMin) e índices topográficos foram analisados pré-operatoriamen

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Duarte, Ana Rute Pires Simões. "Stability of crosslinking treatment combined with excimer laser." Master's thesis, 2020. http://hdl.handle.net/10316/97775.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Objetivo: O objetivo do estudo é avaliar a estabilidade a longo prazo do tratamento de crosslinking, quando associado a ablação com laser excimer, em doentes com queratocone, através da avaliação de parâmetros refrativos e topográficos. Métodos: É um estudo retrospetivo que compara um único grupo de doentes em duas avaliações distintas (6 meses após cirurgia versus última avaliação disponível), submetidos ao tratamento de crosslinking, em associação com queratectomia fotorefrativa parcial.O estudo incluiu 7

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Gonzalez, José Estrela Rego. "Multimodal assessment of functional and structural retinal changes in patients undergoing accelerated corneal collagen cross-linking." Master's thesis, 2017. http://hdl.handle.net/10316/82751.

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Trabalho de Projeto do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Purpose: The purpose of our study was to assess the functional and structural retinal changes in consecutive patients undergoing accelerated corneal collagen cross-linking.Methods: Our study population consisted in ten eyes of 10 consecutive keratoconus patients.All participants underwent a complete ophthalmological examination before surgery.Structural characterization of the central retina by OCT and OCT-A was obtained before surgery and 1 week and 1 month after surgery. Functional assessment of reti

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Pinto, Beatriz Lima Teixeira. ""Avaliação das opções terapêuticas cirúrgicas no queratocone em progressão"." Master's thesis, 2017. http://hdl.handle.net/10316/81958.

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Trabalho de Projeto do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introdução: Avaliar a estabilidade da córnea após tratamento cirúrgico do queratocone progressivo com crosslinking ou implantação de anéis corneanos intraestromais considerando a queratometria, paquimetria, melhor acuidade visual corrigida e erro refrativo.Materiais e Métodos: Neste estudo retrospetivo, foram considerados 2 grupos de olhos com queratocone em progressão. O grupo 1 envolveu olhos que realizaram crosslinking e o grupo 2 envolveu olhos que realizaram implantação de anéis corneanos intraest

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Gonçalves, Diana Filipa Valbom. "Regularização Corneana com Cross- Linking Guiado por Topografia para o Tratamento do Queratocone." Master's thesis, 2020. http://hdl.handle.net/10316/97777.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introdução: O Cross-Linking (CXL) é uma terapêutica em evolução para o tratamento do queratocone em progressão. Os tratamentos convencionais mostraram ser capazes de estabilizar a progressão mas a sua incapacidade de reabilitar a visão é uma insuficiência importante. Com o protocolo clássico, a superfície da córnea é irradiada uniformemente com UVA, independentemente da irregularidade que causa o défice visual. Isto significa que a melhoria refrativa e visual associada aos padrões de CXL é, quando presente,

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Araújo, Mariana Jacinto. "Tear Film Mediators After Cross-Linking." Master's thesis, 2021. http://hdl.handle.net/10316/98370.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Contexto O queratocone é uma patologia oftalmológica caracterizada por ectasia da córnea com protusão em formato cónico que clinicamente leva a astigmatismo irregular, miopia e perda de acuidade visual dificilmente reversível. Atualmente o seu tratamento passa pela realização de cirurgia de cross-linking, que consiste na aplicação de riboflavina e uso de radiação ultravioleta A com o intuito de aumentar a rigidez biomecânica da córnea e parar a progressão da doença. No entanto, os resultados pós-operatóri

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Wójcik, Katarzyna. "Związek zmienności genów naprawy DNA przez wycinanie zasad z występowaniem stożka rogówki i dystrofii śródbłonka rogówki Fuchsa." Phd diss., 2015. http://hdl.handle.net/11089/13204.

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Stożek rogówki (KC, ang. keratoconus) i dystrofia śródbłonka rogówki Fuchsa (FECD, ang. Fuchs endothelial corneal dystrophy) są chorobami, które cechują zmiany w strukturze rogówki prowadzące do znacznego upośledzenia jakości widzenia. KC i FECD należą do schorzeń o złożonej etiologii. Szereg badań sugeruje, że stres oksydacyjny jest istotnym elementem patogenezy obydwu chorób. Stres oksydacyjny i związane z nim uszkodzenia DNA mogą wynikać z różnorodności wariantów genów naprawy DNA. W naprawie uszkodzeń DNA wywołanych stresem oksydacyjnym ważną role odgrywa system naprawy DNA przez wycinanie

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Figueiredo, Carolina Marques Moura de Almeida. "Tratamento do queratocone: comparação de duas abordagens cirúrgicas." Master's thesis, 2020. http://hdl.handle.net/10316/97740.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introdução: Diversas modalidades terapêuticas descritas na literatura têm sido aplicadas ao tratamento do queratocone, nomeadamente o cross-linking (CXL) associado a laser excimer (Protocolo de Atenas), assim como o implante de anéis intra-estromais. As fronteiras entre as indicações para a utilização de uma modalidade face à outra ainda não se encontram completamente definidas. Este trabalho teve como objetivo a comparação de ambas as técnicas cirúrgicas, relativamente aos seus resultados visuais, refrativ

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Lucas, SEM. "Identifying genetic variation contributing to keratoconus." Thesis, 2019. https://eprints.utas.edu.au/31770/1/Lucas_whole_thesis.pdf.

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Keratoconus (OMIM 148300) is a complex disease characterised by progressive stromal thinning and conical protrusion of the cornea. These abnormalities usually develop in the second decade of life and can lead to severe visual impairment as a result of high myopia and irregular astigmatism. Due to the early onset of disease, keratoconus affects individuals during their most productive years and quality of life estimates demonstrate a significant decline over time that is disproportional to visual acuity. The global incidence of keratoconus is approximately 1 in 50,000 and the prevalence in Cauc

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