Relevant bibliographies by topics / Cough

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  2. Dissertations / Theses
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  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'Cough'

Author: Grafiati
Published: 4 June 2021
Last updated: 31 July 2024

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Journal articles on the topic "Cough"

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Barata, Filipe, Peter Tinschert, Frank Rassouli, Claudia Steurer-Stey, Elgar Fleisch, Milo Alan Puhan, Martin Brutsche, David Kotz, and Tobias Kowatsch. "Automatic Recognition, Segmentation, and Sex Assignment of Nocturnal Asthmatic Coughs and Cough Epochs in Smartphone Audio Recordings: Observational Field Study." Journal of Medical Internet Research 22, no. 7 (July 14, 2020): e18082. http://dx.doi.org/10.2196/18082.

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Background Asthma is one of the most prevalent chronic respiratory diseases. Despite increased investment in treatment, little progress has been made in the early recognition and treatment of asthma exacerbations over the last decade. Nocturnal cough monitoring may provide an opportunity to identify patients at risk for imminent exacerbations. Recently developed approaches enable smartphone-based cough monitoring. These approaches, however, have not undergone longitudinal overnight testing nor have they been specifically evaluated in the context of asthma. Also, the problem of distinguishing partner coughs from patient coughs when two or more people are sleeping in the same room using contact-free audio recordings remains unsolved. Objective The objective of this study was to evaluate the automatic recognition and segmentation of nocturnal asthmatic coughs and cough epochs in smartphone-based audio recordings that were collected in the field. We also aimed to distinguish partner coughs from patient coughs in contact-free audio recordings by classifying coughs based on sex. Methods We used a convolutional neural network model that we had developed in previous work for automated cough recognition. We further used techniques (such as ensemble learning, minibatch balancing, and thresholding) to address the imbalance in the data set. We evaluated the classifier in a classification task and a segmentation task. The cough-recognition classifier served as the basis for the cough-segmentation classifier from continuous audio recordings. We compared automated cough and cough-epoch counts to human-annotated cough and cough-epoch counts. We employed Gaussian mixture models to build a classifier for cough and cough-epoch signals based on sex. Results We recorded audio data from 94 adults with asthma (overall: mean 43 years; SD 16 years; female: 54/94, 57%; male 40/94, 43%). Audio data were recorded by each participant in their everyday environment using a smartphone placed next to their bed; recordings were made over a period of 28 nights. Out of 704,697 sounds, we identified 30,304 sounds as coughs. A total of 26,166 coughs occurred without a 2-second pause between coughs, yielding 8238 cough epochs. The ensemble classifier performed well with a Matthews correlation coefficient of 92% in a pure classification task and achieved comparable cough counts to that of human annotators in the segmentation of coughing. The count difference between automated and human-annotated coughs was a mean –0.1 (95% CI –12.11, 11.91) coughs. The count difference between automated and human-annotated cough epochs was a mean 0.24 (95% CI –3.67, 4.15) cough epochs. The Gaussian mixture model cough epoch–based sex classification performed best yielding an accuracy of 83%. Conclusions Our study showed longitudinal nocturnal cough and cough-epoch recognition from nightly recorded smartphone-based audio from adults with asthma. The model distinguishes partner cough from patient cough in contact-free recordings by identifying cough and cough-epoch signals that correspond to the sex of the patient. This research represents a step towards enabling passive and scalable cough monitoring for adults with asthma.
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Vally, M., and M. O. E. Irhuma. "Management of Cough: a practical approach." South African Family Practice 58, no. 4 (August 4, 2016): 35–39. http://dx.doi.org/10.4102/safp.v58i4.4486.

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On a regular day, healthcare providers will be contacted by one or more health seekers presenting with cough as a symptom. Cough has been considered an important physiological reflex that protects the airways from aspiration of foreign materials. Cough is one of the most common symptoms for which people seek medical attention from their healthcare practitioners. The common classifications for cough include acute, subacute and chronic cough. Such classification is time dependant. Acute cough is generally self-limiting, while subacute and chronic coughs have various different causes. There are many different causes of cough, and the common causes of persistent coughs include: upper airway cough syndrome, asthma, gastroesophageal reflux disease (GORD) and even pharmacological therapy. There are other important causes of chronic cough especially in the Southern African region that include: pulmonary tuberculosis (TB), environmental diseases, and others, which will not be covered by this article. Management of subacute and chronic coughs should be individualised according to their cause. Currently, there is no evidence to suggest acute coughs need to be treated. Moreover, there is poor evidence to recommend the use of over the counter (OTC) cough syrups in the management of acute coughs.
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Cho, Peter S. P., Hannah V. Fletcher, Richard D. Turner, Caroline J. Jolley, and Surinder S. Birring. "Impaired cough suppression in chronic refractory cough." European Respiratory Journal 53, no. 5 (February 28, 2019): 1802203. http://dx.doi.org/10.1183/13993003.02203-2018.

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Functional brain imaging in individuals with chronic cough demonstrates reduced activation in cortical regions associated with voluntary cough suppression. Little is known about the ability of patients with chronic cough to suppress cough. This study aimed to compare the ability to voluntarily suppress cough during inhaled capsaicin challenge in participants with chronic refractory cough with that in healthy controls. In addition, this study aimed to assess the repeatability of capsaicin challenge test with voluntary cough suppression.Participants with chronic refractory cough and healthy controls underwent inhaled capsaicin challenge tests while attempting to suppress their cough responses. After 5 days, either a conventional capsaicin challenge test with no cough suppression attempt, or a repeat test with an attempt at cough suppression was performed. Threshold capsaicin concentrations required to elicit one, two and five coughs were calculated by interpolation. Objective 24-h cough frequency was measured in individuals with chronic refractory cough.Healthy controls were able to suppress capsaicin-evoked cough while participants with chronic refractory cough were not. Geometric mean±sd capsaicin dose thresholds for five coughs with (CS5) and without (C5) suppression attempts were 254.40±3.78 versus 45.89±3.95 µmol·L−1, respectively, in healthy controls (p=0.033) and 3.34±5.04 versus 3.86±5.13 µmol·L−1, respectively, in participants with chronic refractory cough (p=0.922). Capsaicin dose thresholds for triggering five coughs with self-attempted cough suppression were significantly lower in participants with chronic refractory cough than in healthy controls; geometric mean±sd 4.94±4.43 versus 261.10±4.34 µmol·L−1, respectively; mean difference (95% CI) 5.72 (4.54–6.91) doubling doses (p<0.001). Repeatability of cough suppression test in both patients and healthy controls was high; intraclass correlation coefficients of log(CS5) values 0.81 and 0.87, respectively. CS5 was associated with objective cough frequency (ρ=−0.514, p=0.029).Participants with chronic refractory cough were less able to voluntarily suppress capsaicin-evoked cough compared to healthy controls. This may have important implications for the pathophysiology and treatment of chronic cough.
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Yang, Bennett E., and Joel Moss. "Cough, Cough." Chest 163, no. 4 (April 2023): 746–48. http://dx.doi.org/10.1016/j.chest.2022.12.009.

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Xiang, Anbo, Yoshiyuki Uchida, Akihiro Nomura, Hiroaki Iijima, Fang Dong, Min-Jie Zhang, and Shizuo Hasegawa. "Effects of airway inflammation on cough response in the guinea pig." Journal of Applied Physiology 85, no. 5 (November 1, 1998): 1847–54. http://dx.doi.org/10.1152/jappl.1998.85.5.1847.

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We have developed a guinea pig model for cough related to allergic airway inflammation. Unanesthetized animals were exposed to capsaicin aerosols for 10 min, and cough frequency was counted during this period. The cough evaluation was performed by the following three methods: visual observation, acoustic analysis, and monitoring of pressure changes in the body chamber. These analyses clearly differentiated a cough from a sneeze. To elucidate the relationship between cough response and airway inflammation, animals were immunosensitized and multiple challenged. Sensitized guinea pigs presented no specific changes microscopically, but multiple-challenged animals showed an increased infiltration of inflammatory cells into the airway. Cough number in response to capsaicin increased significantly from 4.7 ± 1.4 coughs/10 min in normal animals to 10.6 ± 2.0 coughs/10 min in sensitized animals and further to 22.8 ± 1.3 coughs/10 min in multiple-challenged animals. This augmented cough frequency was significantly inhibited by the inhalation of tachykinin-receptor antagonists and by oral ingestion, but not inhalation, of codeine phosphate. The results suggest that airway inflammation potentiates an elevation of cough sensitivity in this model.
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Barry, P. W., N. P. Mason, M. Riordan, and C. O'Callaghan. "Cough Frequency and Cough-Receptor Sensitivity are Increased in Man at Altitude." Clinical Science 93, no. 2 (August 1, 1997): 181–86. http://dx.doi.org/10.1042/cs0930181.

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1. Travellers to high altitude often complain of paroxysmal cough, which has not been previously investigated. We recorded overnight cough frequency and cough-receptor sensitivity to inhaled citric acid in a group of climbers travelling to 5300 m or higher. 2. Cough frequency, monitored in ten subjects, increased from a median of 0 coughs at sea level (range 0–1) to 5 coughs at 5000 m (range 0–13) and to over 60 coughs in subjects ascending to 7000 m. Citric acid cough threshold, measured in 42 subjects, was unchanged on arrival at 5300 m compared with sea level (geometric mean difference 1.26, 95% confidence intervals 0.84–1.89, P = 0.25), but was significantly reduced after 6 days, or more, at altitude compared with sea level (geometric mean difference 2.2, 95% confidence intervals 1.54–3.15, P = 0.0002). Cough threshold was not related to symptoms of acute mountain sickness, oxygen saturation, carbon dioxide tension or lung function. 3. These results indicate an increase in cough and cough-receptor sensitivity after some days at altitude. This may be due to respiratory tract damage from breathing cold dry air at increased ventilatory rates. Other explanations, such as sub-clinical pulmonary oedema or an effect on the cough centre of acclimatization to altitude, cannot be excluded.
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Hee, Hwan Ing, BT Balamurali, Arivazhagan Karunakaran, Dorien Herremans, Onn Hoe Teoh, Khai Pin Lee, Sung Shin Teng, Simon Lui, and Jer Ming Chen. "Development of Machine Learning for Asthmatic and Healthy Voluntary Cough Sounds: A Proof of Concept Study." Applied Sciences 9, no. 14 (July 16, 2019): 2833. http://dx.doi.org/10.3390/app9142833.

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(1) Background: Cough is a major presentation in childhood asthma. Here, we aim to develop a machine-learning based cough sound classifier for asthmatic and healthy children. (2) Methods: Children less than 16 years old were randomly recruited in a Children’s Hospital, from February 2017 to April 2018, and were divided into 2 cohorts—healthy children and children with acute asthma presenting with cough. Children with other concurrent respiratory conditions were excluded in the asthmatic cohort. Demographic data, duration of cough, and history of respiratory status were obtained. Children were instructed to produce voluntary cough sounds. These clinically labeled cough sounds were randomly divided into training and testing sets. Audio features such as Mel-Frequency Cepstral Coefficients and Constant-Q Cepstral Coefficients were extracted. Using a training set, a classification model was developed with Gaussian Mixture Model–Universal Background Model (GMM-UBM). Its predictive performance was tested using the test set against the physicians’ labels. (3) Results: Asthmatic cough sounds from 89 children (totaling 1192 cough sounds) and healthy coughs from 89 children (totaling 1140 cough sounds) were analyzed. The sensitivity and specificity of the audio-based classification model was 82.81% and 84.76%, respectively, when differentiating coughs from asthmatic children versus coughs from ‘healthy’ children. (4) Conclusion: Audio-based classification using machine learning is a potentially useful technique in assisting the differentiation of asthmatic cough sounds from healthy voluntary cough sounds in children.
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Poliacek, Ivan, Kendall F. Morris, Bruce G. Lindsey, Lauren S. Segers, Melanie J. Rose, Lu Wen-Chi Corrie, Cheng Wang, Teresa E. Pitts, Paul W. Davenport, and Donald C. Bolser. "Blood pressure changes alter tracheobronchial cough: computational model of the respiratory-cough network and in vivo experiments in anesthetized cats." Journal of Applied Physiology 111, no. 3 (September 2011): 861–73. http://dx.doi.org/10.1152/japplphysiol.00458.2011.

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We tested the hypothesis, motivated in part by a coordinated computational cough network model, that alterations of mean systemic arterial blood pressure (BP) influence the excitability and motor pattern of cough. Model simulations predicted suppression of coughing by stimulation of arterial baroreceptors. In vivo experiments were conducted on anesthetized spontaneously breathing cats. Cough was elicited by mechanical stimulation of the intrathoracic airways. Electromyograms (EMG) of inspiratory parasternal, expiratory abdominal, laryngeal posterior cricoarytenoid (PCA), and thyroarytenoid muscles along with esophageal pressure (EP) and BP were recorded. Transiently elevated BP significantly reduced cough number, cough-related inspiratory, and expiratory amplitudes of EP, peak parasternal and abdominal EMG, and maximum of PCA EMG during the expulsive phase of cough, and prolonged the cough inspiratory and expiratory phases as well as cough cycle duration compared with control coughs. Latencies from the beginning of stimulation to the onset of cough-related diaphragm and abdominal activities were increased. Increases in BP also elicited bradycardia and isocapnic bradypnea. Reductions in BP increased cough number; elevated inspiratory EP amplitude and parasternal, abdominal, and inspiratory PCA EMG amplitudes; decreased total cough cycle duration; shortened the durations of the cough expiratory phase and cough-related abdominal discharge; and shortened cough latency compared with control coughs. Reduced BP also produced tachycardia, tachypnea, and hypocapnic hyperventilation. These effects of BP on coughing likely originate from interactions between barosensitive and respiratory brainstem neuronal networks, particularly by modulation of respiratory neurons within multiple respiration/cough-related brainstem areas by baroreceptor input.
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Sanchez-Olivieri, Isabel, Matthew Rudd, Juan Carlos Gabaldon-Figueira, Francisco Carmona-Torre, Jose Luis Del Pozo, Reid Moorsmith, Lola Jover, et al. "Performance evaluation of human cough annotators: optimal metrics and sex differences." BMJ Open Respiratory Research 10, no. 1 (November 2023): e001942. http://dx.doi.org/10.1136/bmjresp-2023-001942.

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IntroductionDespite its high prevalence and significance, there is still no widely available method to quantify cough. In order to demonstrate agreement with the current gold standard of human annotation, emerging automated techniques require a robust, reproducible approach to annotation. We describe the extent to which a human annotator of cough sounds (a) agrees with herself (intralabeller or intrarater agreement) and (b) agrees with other independent labellers (interlabeller or inter-rater agreement); we go on to describe significant sex differences in cough sound length and epochs size.Materials and methods24 participants wore an audiorecording smartwatch to capture 6–24 hours of continuous audio. A randomly selected sample of the whole audio was labelled twice by an expert annotator and a third time by six trained annotators. We collected 400 hours of audio and analysed 40 hours. The cough counts as well as cough seconds (any 1 s of time containing at least one cough) from different annotators were compared and summary statistics from linear and Bland-Altman analyses were used to quantify intraobserver and interobserver agreement.ResultsThere was excellent intralabeller (less than two disagreements per hour monitored, Pearson’s correlation 0.98) and interlabeller agreement (Pearson’s correlation 0.96), using cough seconds as the unit of analysis decreased annotator discrepancies by 50% in comparison to coughs. Within this data set, it was observed that the length of cough sounds and epoch size (number of coughs per bout or attach) differed between women and men.ConclusionGiven the decreased interobserver variability in annotation when using cough seconds (vs just coughs) we propose their use for manually annotating cough when assessing of the performance of automatic cough monitoring systems. The differences in cough sound length and epochs size may have important implications for equality in the development of cough monitoring tools.Trial registration numberNCT05042063.
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Gavliakova, S., T. Dolak, H. Licha, S. Krizova, and J. Plevkova. "Cineole, Thymol and Camphor Nasal Challenges and their Effect on Nasal Symptoms and Cough in an Animal Model." Acta Medica Martiniana 13, no. 2 (November 1, 2013): 5–13. http://dx.doi.org/10.2478/acm-2013-0012.

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Abstract Inhalation of aromatic vapours suppressed coughing induced by citric acid (CA) in naive animals. No data are available about their effects in an animal model with primarily up-regulated cough reflex. New data indicate that aromatic vapours suppress cough via effect on nasal sensory nerves. The aim of our study was to ascertain the efficacy of nasal application of 1,8-cineole, thymol and camphor on nasal symptoms and CA induced cough in validated model of up-regulated cough reflex. Guinea pigs (n=13) were sensitized by intraperitoneal administration of ovalbumin (OVA) and sensitization was confirmed 21 days later by skin tests. Sensitized animals were repeatedly challenged with nasal OVA to induce rhinitis, and further experiments (cough challenges) were performed during the early phase of allergic inflammation. Cough was induced by CA in plethysmograph for 10 minutes after nasal pre-treatment with aromatic substances (10-3M) in rhinitis model. Cough was recognized from record of sudden airflow changes interrupting breathing pattern and cough sound. Final count of coughs was established by blind analysis using SonicVisualiser Software. Dose responses curves, total cough count and cough latency were analyzed. Repeated intranasal challenge with OVA induces progressively worsening symptoms, and cough induced by CA during acute phase of allergic rhinitis was enhanced. Nasal pre-treatment with 1,8-cineole, thymol and camphor did not prevent onset of nasal symptoms, and the magnitude of symptoms was comparable to those without pretreatment. Camphor had the most potent antitussive effects (number of coughs 25±3 vs. 7±2, p<0.05) followed by thymol (number of coughs 25±3 vs. 14±2, p<0.05). The data for nasal 1,8-cineole challenge did not reach statistical significance. Cough latency followed this trend. Although the magnitude of nasal symptoms is not influenced, the effect on cough is in case of camphor and thymol significant. Our data showed that nasal application of aromatic substances suppress citric acid induced cough in animals with up-regulated cough reflex.
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Dissertations / Theses on the topic "Cough"

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Khalid, Saifudin. "Inhalational cough challenges in the assessment of cough." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/inhalational-cough-challenges-in-the-assessment-of-cough(8788e20e-3f76-4600-bdc1-e9bee31b5c01).html.

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Introduction: Cough is the commonest reason for which medical advice is sought. In assessment of chronic cough and in developing anti-tussive medications, inhalational cough challenges with capsaicin and citric acid are commonly employed. However the ability of these inhalational cough challenges to distinguish health and disease is not clear and it is not known which end point is best in making such assessments. Methods: Subjects belonging to five different categories (healthy volunteers, subjects with COPD, asthma, healthy current smokers and chronic cough) were compared with each another by using the standard cough challenges employing Capsaicin and Citric acid and also by using newer inhalational cough challenge agents such as prostaglandin E2 and bradykinin. In addition adaptation to repeated inhalations of tussive agents was also assessed. The relationship between the cough reflex sensitivity as gauged by using inhalational cough challenge tests and objective cough recording was explored in all five groups. Finally the change in C5 in Capsaicin evoked cough by using a substance to block TRPV1 channel and its effect on objective cough recording was assessed in subjects with chronic cough. Results: Different tussive agents have different abilities to distinguish between different diagnostic categories and a combination of inhalational cough challenge tests have a better accuracy of predicting diagnostic groups as compared to one on its own. There are significant differences in the rates of adaptation to repeated inhalations of PGE2 and there is a significant reduction in cough response over period of time in all disease groups. Using the TRPV1 antagonist resulted in a modest increase in the Log C5 concentration of capsaicin but this was not matched by a change in objective cough recording or CQLQ scores. Conclusions: The different abilities of tussive agents to distinguish between different diagnostic categories suggest that the information conveyed by the one inhalational cough challenge test is different from that by another test. The choice of the inhalational cough challenge test should therefore depend on which groups are included in the study. There was no significant difference in the rate of adaptation to prolonged challenge with citric acid or capsaicin and no significant correlation of the magnitude of adaptation with objective cough recording suggesting that this is unlikely to be responsible for the increased cough rates seen in diseases such as chronic cough, COPD or asthma. The TRPV1 antagonist did not result in a significant change in objective cough recording or CQLQ scores. The change in C5 with the TRPV1 antagonist was however modest and this may be reason for this study failing to show a relationship between these different measures.
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Hassan, H., Gayatri Jaishankar, and Demetrio Macariola. "The "Non" Whooping Cough." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etsu-works/8861.

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Pillay, Victoria. "A systematic review of the symptomatic treatment of the cough in whooping cough." Master's thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/8789.

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Includes bibliographical references.
Background: There are between 20 - 40 million cases of whooping cough annually world-wide, 90% of which occur in developing countries, resulting in an estimated 200 - 300 O00 fatalities each year. Much of the morbidity is due to the paroxysmal cough. Corticosteroids, salbutamol (a β₂- adrenergic stimulant), and pertussis-specific immunoglobulin have been proposed as standard treatment for the cough. Antihistamines have also been administered. No systematic review of the effectiveness of any of these interventions or others has been performed. Objective: in this systematic review we aim to assess the effectiveness of interventions used to reduce the severity of the coughing paroxysms in whooping cough in children and adults. Selection criteria: Randomised and quasi randomised controlled trials of any intervention that reduced the severity of the coughing paroxysms in whooping cough; excluding antibiotics and vaccines. Study selection: All interventions aimed at reducing the severity of the coughing paroxysms in children or adults with whooping cough with any of the following outcome measures met inclusion criteria for the review; i) frequency of paroxysms of coughing (primary outcome), ii) frequency of vomiting, iii) frequency of whoop, iv) frequency of cyanotic spells, v) development of serious complications, vi) mortality from any cause, vii) side effects due to medication, viii) admission to hospital, and ix) duration of hospital stay. Search strategy: We searched the Cochrane Controlled Trials register, Acute Respiratory infectious Disease Group Specialised Trials register, MEDLINE, LILACS, scanned reference lists of identified trials, contacted authors of identified trials and the relevant pharmaceutical companies. Data collection and analysis: Studies were selected, quality assessed and data extracted by two reviewers independently. Results: Nine studies satisfied the inclusion criteria but four had insufficient data for further meta-analysis of our pre-specified outcomes. Studies were old and poorly reported. The largest study had a total sample size of 49 and the smallest study nine. All studies were performed in industrialised settings. Eligible studies assessed diphenhyramine, pertussis immunoglobulin, dexamethasone and salbutamol. No statistically significant benefit was found for any of the interventions. Diphenhydramine was associated with a mean increase of 1.90 coughing spells per 24 hours [95%Cl - 4.66; 8.46] and pertussis immunoglobulin a mean decrease in hospital stay of 0.70 days [95% Cl -3.79; 2.39]. and a mean reduction of 3.10 whoops per 24 hours [95% CI - 6.22; 0.02]. Dexamethasone resulted in a mean decrease in hospital stay of 3.45 days [95% Cl - 15.34; 8.44] and salbutamol in a weighted mean decrease in coughing paroxysms of 0.95 per 24 hours [95% Cl - 6.21; 4.31]. Reviewers' conclusion: Although assessments have been performed on a whole range of interventions, including diphenhyramine, pertussis immunoglobulin, dexamethasone and salbutamol, insufficient evidence exists to draw conclusions about the effects of any of them.
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Mason, Nicholas. "Mechanisms of altitude-related cough." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209711.

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The original work presented in this thesis investigates some of the mechanisms that may be responsible for the aetiology of altitude-related cough. Particular attention is paid to its relationship to the long recognised, but poorly understood, changes in lung volumes that occur on ascent to altitude. The literature relevant to this thesis is reviewed in Chapter 1.

Widespread reports have long existed of a debilitating cough affecting visitors to high altitude that can incapacitate the sufferer and, on occasions, be severe enough to cause rib fractures (22, 34, 35). The prevalence of cough at altitude has been estimated to be between 22 and 42% at between 4200 and 4900 m in the Everest region of Nepal (10, 29). Traditionally the cough was attributed to the inspiration of the cold, dry air characteristic of the high altitude environment (37) but no attempts were made to confirm this aetiology. In the first formal study of cough at high altitude, nocturnal cough frequency was found to increase with increasing altitude during a trek to Everest Base Camp (5300 m) and massively so in 3 climbers on whom recordings were made up to 7000 m on Everest (8). After 9 days at 5300 m the citric acid cough threshold, a measure of the sensitivity of the cough reflex arc, was significantly reduced compared with both sea level and arrival at 5300 m.

During Operation Everest II, a simulated climb of Mount Everest in a hypobaric chamber, the majority of the subjects were troubled above 7000 m by pain and dryness in the throat and an irritating cough despite the chamber being maintained at a relative humidity of between 72 and 82% and a temperature of 23ºC (18). This argued against the widely held view that altitude-related cough was due to the inspiration of cold, dry air.

In the next major hypobaric chamber study, Operation Everest III, nocturnal cough frequency and citric acid cough threshold were measured on the 8 subjects in the study. The chamber temperature was maintained between 18 and 24ºC and relative humidity between 30 and 60% (24). This work is presented in Chapter 2 and, demonstrated an increase in nocturnal cough frequency with increasing altitude which immediately returned to control values on descent to sea level. Citric acid cough threshold was reduced at 8000 m compared to both sea level and 5000 m values. Changes in citric acid cough threshold at lower altitudes may not have been detected because of the constraints on subject numbers in the chamber. The study still however demonstrated an increase in clinical cough and a reduction in the citric acid cough threshold at extreme altitude, despite controlled environmental conditions, and thus refuted the long held belief that altitude-related cough is solely due to the inspiration of cold, dry air.

If altitude-related cough is not simply due to the inspiration of cold, dry air, other possible aetiologies are:

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Doctorat en Sciences médicales
info:eu-repo/semantics/nonPublished

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Dixon, Nicola Jane. "The psychology of chronic cough." Thesis, University of Hull, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395657.

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Yousaf, Nadia. "Cough in health and disease." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/28114.

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Cough is a common symptom of both acute and chronic respiratory illness. It is poorly understood and treatment options are sparse. One reason is that there are few validated objective measures of cough frequency and severity. In this thesis I have further validated the Leicester Cough Monitor, an automated cough detection system capable of detecting coughs over 24 hours. I have demonstrated that automated cough numbers were similar to those derived from the gold standard of manual counting in healthy adults and in patients with respiratory disease. Cough frequency was then measured using the Leicester Cough Monitor and was almost 16 fold higher in patients with respiratory diseases compared to healthy controls. In the population as a whole there was a correlation between cough frequency and the induced sputum neutrophil count. I then conducted a randomised, placebo controlled, double blind, parallel group trial of low dose erythromycin taken daily for 3 months in 30 patients with unexplained chronic cough. Active treatment was associated with a reduction in the sputum neutrophil count but no difference in cough counts or other measures of cough severity. Also, there is no information on the natural history of unexplained chronic cough. In a longitudinal study of 42 patients with unexplained chronic cough followed up for at least 7 years, I found that cough, measure by the cough visual analogue score, improved in 25 percent. Unexpectedly, patients had an abnormally rapid fall in FEV1, whether cough improved or not. Finally, the assessment of health related quality of life is important in people with acute cough in order to evaluate potential therapies. I have shown that that the minimal important clinical difference in the Leicester Cough Questionnaire for those with acute cough is 2.5 and this will aid in the interpretation of treatment trials.
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Kelsall, Angela. "Respiratory physiology in chronic cough." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491479.

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Introduction: Varying methods of cough quantification have been used to describe cough frequency, although there is no consensus which method best relates to subjective rating of cough. With increased availability of semi-automated cough recording devices, the capability to carryout anti-tussive studies is greatly increased. However, there is no data available describing the magnitude of change in cough frequency necessary to provide therapeutic benefit. Female patients are over represented in specialist cough clinics. There is little data describing pulmonary function and airway inflammation in phenotyped patients and how these measures may relate to objectively measured cough. Airway inflammation isa common feature of chronic cough, regardless of the trigger for cough. The repetitive mechanical insult of the act of coughing may be responsible for the presence ofthis inflammation. Methods: 100 patients with unexplained chronic cough under went full diagnostic testing in order to determine potential triggers for cough. Procedures included pulmonary function testing; (spirometry, eND, EBC pH, BHR, Cough challenge, induced sputum, objective and subjective cough monitoring), Bronchoscopy, 24 hour impedance monitoring with simultaneous cough monitoring, Gastroscopy and ENT. A subset of cough recordings were quantified in cough sounds, cough seconds and cough epochs to determine the best way to quantify cough. 20 healthy volunteers performed voluntary coughing manoeuvres to determine the acute effects of coughing on airway function and inflammation. Results: Cough sounds and seconds correlate moderately with subjective and QDL . methods. Patients reported a reduced cough frequency whilst undergoing impedance testing; a reduction of33% was seen although patients were unable to quantify the scale of change. Female patients coughed substantially more than male patients, with the largest difference seen at night. Cough frequency was predicted by gender, C5 and age. Cough frequency was not related to a specific trigger for cough. Reduced small airway flows were seen that were independent of BHR. Prominent airway neutrophilia was seen regardless of the trigger for cough. Acute changes in eND and EBC were seen after short periods ofvoluntary coughing. Sputum inflammatory mediator levels showed huge variability and did not change as a result of coughing. Bronchodilation ofthe small airways was also seen after coughing. Conclusion: The use of objective cough monitoring has enabled me for the first time to describe the most appropriate current methods of cough quantification and to demonstrate the magnitude ofreduction in cough frequency that is appreciated by -patients.-I-havereportedimportant significant genderdifferences in cough frequency and shown that cough frequency is predicted not only by gender but also age and cough reflex sensitivity showing important implications for underlying mechanisms of chronic cough. I have also shown for the first time that pulmonary function measures are reduced in patients without indication of asthma. The mechanical act of coughing causes acute bronchodilation of small airways and reduces eND and EBC pH.
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Marsden, Paul Anthony. "Cough, asthma and airways inflammation." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516825.

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Rationale Cough is an important symptom in asthma. In addition, cough is both troublesome to patients and may be important in the development of more severe disease. Moreover, it is a key symptom in the diagnosis of asthma, according to international guidelines. Little is known regarding the mechanism of cough in asthma. Until now, subjective measures of cough have been used in mechanistic and therapeutic studies relating to both cough in asthma and chronic cough. There is no published literature documenting cough rates in asthma or the relationship between cough rates and both subjective measures of cough and asthma control. In addition, the relationship between objective cough rates and airway inflammation, and the effects of cough on airway function and inflammation is unknown. Methods A series of studies was designed and carried out to answer the above questions. Firstly, a cross sectional study examining the relationships between objective and subjective measures of cough in classical asthma (CA), secondly a longitudinal study examining the relationship between cough rates and CA control and thirdly a cross-sectional study examining the effects of voluntary cough on airway function and inflammation. Results There was a poor correlation between objective and subjective measures of cough in CA. Cough-related quality of life correlated most closely with cough rates. Traditional measures of CA (e.g. spirometry) poorly reflected cough rates. Objective cough rates and sputum eosinophils were predictive of CA control as defined by ACO. Objective cough rates did not reflect sputum inflammatory cell count or mediators. Voluntary cough induced small changes in peak flow in mildmoderate CA and small changes in sputum ECP that were not reflected by changes in sputum eosinophils. Conclusions Subjective measures of cough in asthma are poor substitutes for objective cough rates. When designing studies for cough in asthma, both objective cough rates and cough-related quality of life should be incorporated. Objective cough rates reflect asthma control (independent of airway inflammation) more closely than traditional measures of asthma. Airway inflammation does not appear to directly reflect cough rates. In addition, short bouts of coughing in mildmoderate asthma induce neither significant changes in airway function nor airway inflammation.
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McGuinness, Kevin. "Cough detection. a physiological approach." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528494.

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Elghamoudi, Deblej. "Objective cough monitoring in children." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/objective-cough-monitoring-in-children(e3d822f0-d1b1-4056-8f98-1b6dd634c47f).html.

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Background: Cough is extremely common in childhood and a tool to objectively measure cough frequency would be clinically beneficial. To date paediatric cough monitoring systems have relied on manual cough counting which is time consuming and costly. The VitaloJAK™ (Vitalograph, UK) is a custom built 24hr semi-automated cough monitoring device that has been used successfully to quantify cough in adults. This thesis consists of a series of studies using the VitaloJAK™ monitor system in children. Methods: Firstly, we tested the feasibility of using the VitaloJAK™ for 24 hr cough recordings in children and tested existing compression software for cough quantification. The VitaloJAK™ system was then used to to assess and compare the cough frequency, variation and circadian distribution of cough in children with asthma, CF, and PCD during stable periods of disease and during an exacerbation. Finally, we used modelling to assess whether cough events are random events, or are clustered in time; the time intervals between coughs for each patient were calculated and fitted to an exponential model of random recurrences and a Weibull model for clustered recurrences. Results: The majority of children were able to wear the monitor for almost 24 hours without too much difficulty; overall, children wore the monitor for a median of 22.25 hours (0.38 – 24hrs). Using the compression software, a median of 100% (91-100) of coughs was retained and 24-hour records were reduced down to around 10% of their original size. There was no significant difference in cough frequency between the three disease groups. The median (range) cough frequency per hour was 3 (0.2 to 18) coughs/hour (c/h), 4 (0.5 to 37) c/h, and 4 (0.5 to 27) c/h for asthma, CF, and PCD groups respectively (p=0.3). Cough frequency in children was significantly greater during the day and reduced during sleep in all disease groups. There was a significant difference in the 24-hour cough frequency between the exacerbation and stable asthma group (median 11 (0-27) vs. 3 (0-5), p=0.004). The 24-hour pattern revealed a substantial variability in peak timing of cough in each respiratory disease. Children with asthma peaked in the early evening, those with CF in the morning, and those with PCD in the afternoon. No difference was found in the circadian cough rate, when divided into 6 4-hour time periods, either between the three diseases (p=0.18) or between stable and exacerbation phases among the asthmatic children (p=0.14). A significant difference was seen in the 24-hour total cough frequency between asthmatic children (median 4c/h; range 1-18) and adults (median 1 c/h; range 0.3-16); p=0.001. The temporal pattern of recurrence of cough events is non-randomly distributed over time, and this was best described by the Weibull model in the majority of the 24hr cough, day-time cough and night-time cough recordings in children and adults. The cough events appear to cluster together in time, with the probability of a second cough being initially high and decreasing with time. Conclusion: This thesis has demonstrated that the VitaloJAK™ semi-automated cough monitor provides an accurate estimate of cough frequency in children (sensitivity 100%) while significantly reducing the time required for analysis. A substantial variability in the timing of peak cough frequency exists in each respiratory disease and this might reflect different mechanisms of cough in each disease. Sleep appears to significantly reduce cough in all the diseases studied, both when disease is stable and exacerbating. In both asthmatic children and adults, the recurrence pattern of coughs is clustered and can be described by a Weibull distribution. This work has set a foundation for further investigation of the cough frequency and 24 hour cough circadian patterns in children.
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Books on the topic "Cough"

1

Carlo, Braga Pier, and Allegra Luigi, eds. Cough. New York: Raven Press, 1989.

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Allman, Toney. Whooping cough. Detroit: Lucent Books, 2012.

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Guilfoile, Patrick. Whooping cough. New York: Chelsea House, 2010.

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Guilfoile, Patrick. Whooping cough. New York: Chelsea House, 2010.

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Oregon. Dept. of Human Services. and Association for Professionals in Infection Control and Epidemiology., eds. Cover your cough. [Salem, Or.]: Dept. of Human Services, 2006.

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Edward, Redington Anthony, and Morice Alyn H, eds. Acute and chronic cough. Boca Raton: Taylor & Francis, 2005.

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Juraj, Korpas, Paintal A. S, and Anand Ashima, eds. Cough: From lab to clinic. Tunbridge Wells, UK: Anshan, 2007.

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Chung, Kian Fan, and John Widdicombe, eds. Pharmacology and Therapeutics of Cough. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-79842-2.

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Chung, Kian Fan, John G. Widdicombe, and Homer A. Boushey, eds. Cough: Causes, Mechanisms and Therapy. Malden, Massachusetts, USA: Blackwell Publishing Ltd, 2003. http://dx.doi.org/10.1002/9780470755846.

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Zanasi, Alessandro, Giovanni A. Fontana, and Donatella Mutolo, eds. Cough: Pathophysiology, Diagnosis and Treatment. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-48571-9.

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Book chapters on the topic "Cough"

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Anne, Samantha, and Robert F. Yellon. "Cough." In Pediatric Otolaryngology for the Clinician, 173–79. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-127-1_22.

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Glashan, Elizabeth, and Sherif Hanafy Mahmoud. "Cough." In Patient Assessment in Clinical Pharmacy, 67–78. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11775-7_5.

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Meadows-Oliver, Mikki. "Cough." In Clinical Case Studies for the Family Nurse Practitioner, 45–47. West Sussex, UK: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118785829.ch10.

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Sandler, Gerald, and John Fry. "Cough." In Early Clinical Diagnosis, 233–67. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4147-2_9.

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Liu, Zhanwen. "Cough." In Essentials of Chinese Medicine, 13–23. London: Springer London, 2009. http://dx.doi.org/10.1007/978-1-84882-596-3_2.

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Liu, Zhanwen. "Cough." In Essentials of Chinese Medicine, 969–79. London: Springer London, 2010. http://dx.doi.org/10.1007/978-1-84882-112-5_22.

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Rozanski, Elizabeth. "Cough." In Clinical Medicine of the Dog and Cat, 17–19. 4th ed. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003254591-4.

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Soghier, Israa, and Kiyoshi Kinjo. "Cough." In Handbook of Outpatient Medicine, 187–99. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-68379-9_10.

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Ware, Wendy A., John D. Bonagura, and Brian A. Scansen. "Cough." In Cardiovascular Disease in Companion Animals, 203–10. 2nd ed. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9780429186639-11.

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Soghier, Israa, and Kiyoshi Kinjo. "Cough." In Handbook of Outpatient Medicine, 235–50. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-15353-2_11.

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Conference papers on the topic "Cough"

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Damani, Shivam, Arshia K. Sethi, Bhavana Baraskar, Keerthy Gopalakrishnan, Joshika Agarwal, Hasan A. Albitar, Vaibhav Ahluwalia, Sue Ann P. Donlinger, Vivek Iyer, and Shivaram P. Arunachalam. "COUGH AUDIO SENTIMENT ANALYTICS FOR SOFTWARE AS A MEDICAL DEVICE APPLICATIONS." In 2023 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/dmd2023-1316.

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Abstract Chronic cough is not only one of the leading causes of seeking healthcare all over the world but also a huge emotional drain on the affected patient population. In this study, we used 24-hour cough recordings to analyze the intervening conversations for sentiment analyses to better diagnose, guide, and manage treatment in such patients. We surveyed a cough clinic and selected four subjects with active cough complaints using relevant ICD-10 codes. Subjects were given and instructed to wear a device to record cough for 24 hours and the recordings were collected at weeks 0, 4, 8, and 12 of the treatment. The collected data was preprocessed to eliminate sections with no data (sleep, silence) and the number of coughs was counted. Google search API calls were used to transcribe the audio files and NLTK’s VADER analyzer was used to classify sentiments on a scale of 0 to 1. Finally, average scores were calculated and plotted over a graph to interpret any trends. 12 weeks of cough treatment had varied results on the four subjects. We categorized the exhibited sentiments into negative, neutral, positive, and compound and noted that they also showed no general trends. Among these, the compound sentiment displayed the most erratic patterns, and the obtained results could not generate a steady trend. Further studies are required with a large cohort to collect data over a longer duration to accurately analyze the sentiments associated with chronic cough.
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Fletcher, Hannah, Peter Siu Pan Cho, Sérgio Matos, Claire Wood, Tracey Fleming, Richard Turner, and Surinder Birring. "Chronic cough: objective cough frequency in a large cough clinic cohort." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.oa4677.

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Lee, Kai K., Sergio Matos, David H. Evans, Ian D. Pavord, and Surinder Birring. "Changes In Cough Frequency, Cough Severity And Quality Of Life In Acute Cough." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5850.

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Pahar, Madhurananda, Marisa Klopper, Byron Reeve, Rob Warren, Grant Theron, Andreas Diacon, and Thomas Niesler. "Wake-Cough: cough spotting and cougher identification for personalised long-term cough monitoring." In 2022 30th European Signal Processing Conference (EUSIPCO). IEEE, 2022. http://dx.doi.org/10.23919/eusipco55093.2022.9909522.

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Pulido, S. A., R. H. Acuna Cordero, R. CHASKEL, D. P. CHAVEZ, and M. C. DEAZA. "Brain Cough." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5339.

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Lee, Kai K., Sergio Matos, David H. Evans, Ian D. Pavord, and Surinder S. Birring. "Repeatability Of Cough Frequency Monitoring In Acute Cough." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5851.

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Aliabadi, Amir A., Steven N. Rogak, Sheldon I. Green, and Karen H. Bartlett. "CFD Simulation of Human Coughs and Sneezes: A Study in Droplet Dispersion, Heat, and Mass Transfer." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-37331.

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A Computational Fluid Dynamics simulation of near-field cough and sneeze droplet dispersion and heat and mass transfer is developed. In this study various sources of variability in cough and sneeze processes are considered. These are variations in injection volume (0.5l, 2.5l, and 5.0l) and ambient relative humidity (20%, 40% and 60%). There are a total of 9 simulations for coughs and sneezes in a quiescent background. A large ensemble (5000) of droplets are tracked with diameters in the range 1–500micron. Evaporation and dispersion are predicted as a function of droplet size. Generally, fine droplets evaporate faster than large droplets. Higher relative humidities slow the evaporation process. Larger droplets have greater axial penetration. They also exhibit greater vertical drop due to the effect of gravity. Sideway penetration is increased by higher injection volumes. The buoyancy effect due to thermal energy of the injection is very weak, at least for the 10-second computation duration.
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Gavriely, N., Y. Guryachev, E. Dekel, and D. Goldstein. "Simulated Cough-Based Database for Cough-Counting Algorithm Validation." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4429.

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Leamy, Paul, Ted Burke, and David Dorran. "Analysis of cough sound observed by different cough etiquettes." In 2021 32nd Irish Signals and Systems Conference (ISSC). IEEE, 2021. http://dx.doi.org/10.1109/issc52156.2021.9467880.

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Rybka, Aleksandra, Marta Dabrowska, Katarzyna Bialek-Gosk, Elzbieta Grabczak, and Rafal Krenke. "Cough reflex sensitivity in patients with cough variant asthma." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa5032.

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Reports on the topic "Cough"

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Yuan, Yang, Xu Li, Bengang Wang, Dong Tang, Fang Yuan, Rong Li, and Chengshi He. Effect and safety of Huanglong Cough Oral Liquid for cough variant asthma _ A protocol for meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2020. http://dx.doi.org/10.37766/inplasy2020.12.0046.

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Mao, Hui, YueHui Wei, Huimin Su, and Xun Li. Pediatric Tui Na for cough in children: A protocol for a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0076.

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Review question / Objective: The aim of this systematic review is to evaluate the effectiveness and safety of pediatric Tui Na in the treatment of cough in children under seven years of age. Condition being studied: Cough is essentially a protective reflex of respiratory tract to various stimuli, typically in order to clear the lung airways of fluids, mucus, or other material. Cough not only has a negative impact on children’s daily activities and sleep, but is associated with parental stress and worries. Pediatric Tui Na, a therapeutic massage based on the Chinese traditional theory of Yin and Yang, Qi and blood, acupoints and meridians, enjoys a long history and has been widely applied to the treatment of common diseases like fever, diarrhea, cough and asthma. This study aims to evaluate the effectiveness and safety of pediatric Tui Na in the treatment of cough in children.
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Cai, Haiyang, Weihong Li, Shixin Kang, Jing He, Peng Yu, and Han Li. Zhisou Powder in treatment of postinfectious cough: A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2020. http://dx.doi.org/10.37766/inplasy2020.9.0096.

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Heng, Zhaorui, Han Jing, Wangjian Xing, Hanze Lu, Zhang Qing, Wanjing Xuan, and Linjiang Tao. Safety and efficacy of acupuncture for treatment of cough variant asthma: a systematic review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2021. http://dx.doi.org/10.37766/inplasy2021.1.0105.

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Yuan, Yu, Linjia Wang, Yuan Chen, Mengdi Zhou, Bingyu Hu, and Ling Zhao. Acupuncture therapy for subacute and chronic cough in adults: a systematic review and meta analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2022. http://dx.doi.org/10.37766/inplasy2022.7.0110.

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Review question / Objective: The effectiveness of acupuncture in the treatment of subacute and chronic cough. Eligibility criteria: In the literature, the intervention measures of the treatment group were acupuncture or acupuncture combined with other therapies agent, while the control group was placebo or oral non-acupuncture therapy such as western medicine and Chinese medicine; In the same study, when the treatment group was acupuncture combined with other treatment methods, the intervention measures adopted by the control group, except no acupuncture intervention, must be the same as the experimental group .We excluded trials comparing one acupuncture therapy with another, or trials comparing the use of other non- acupuncture related therapy in this review, and trials where acupuncture therapy were not the main intervention were excluded. No limitations were imposed concerning the duration of the application, dosage, or the form of the acupuncture therapy used. We included trials that allowed concurrent use of other medications such as analgesics, antitussives, antipyretics, or mucolytics if they allowed equal access to such medication.
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Zhang, Ye, Hongshi Zhang, Le Liu, and Xiuling Zhou. Therapeutic effect of acupuncture combined montelukast sodium on cough variant asthma in children：A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2021. http://dx.doi.org/10.37766/inplasy2021.11.0006.

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Shang, GuangYuan, ShuangZhu Lin, GuiLin Wang, MeiJia Qian, XiaoChun Feng, and Kai Jiang. A meta-analysis of the efficacy and safety of Chinese herbal compound in the treatment of children with cough variant asthma. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2021. http://dx.doi.org/10.37766/inplasy2021.1.0087.

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Wang, Xiangli, Liuqiao Zhang, and Mengjie Ma. Efficacy and safety of Banxia Houpu decoction in the treatment of gastroesophageal reflux cough A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2021. http://dx.doi.org/10.37766/inplasy2021.6.0010.

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Ly, Lena, Jennifer Philip, Peter Hudson, and Natasha Smallwood. Singing for people with advance chronic respiratory diseases: a qualitative meta-synthesis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2022. http://dx.doi.org/10.37766/inplasy2022.8.0017.

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Review question / Objective: This study undertook a meta-synthesis of qualitative data with the aim of collating, synthesizing, and evaluating the current evidence regarding the experiences of singing for people with advanced chronic respiratory disease. Condition being studied: Advanced respiratory illnesses are disorders that impact the airways and other structures of the lung. People with lung cancer, chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) frequently experience progressive, frightening breathlessness, cough and fatigue, which affect their quality of life. Furthermore, people with advanced chronic respiratory disease (CRD) and their carers experience a high prevalence of loneliness and uncertainty, especially if breathlessness is felt to herald death and thus, require both psychological and practical supportive care to cope with their symptoms.
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MO, Jingwen, Yiyi Zhang, Lingling Han, and Huiling Tang. Efficacy of combination of Shegan Mahuang Decoction and Montelukast Sodium in the Treatment of Cough Variant Asthma: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2021. http://dx.doi.org/10.37766/inplasy2021.12.0107.

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