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Journal articles on the topic 'CPV'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Yang, Dong-Kun, Ha-Hyun Kim, Hye Jeong Lee, et al. "Incidence of canine viral diseases and prevalence of virus neutralization antibodies of canine distemper virus, adenovirus type 2, parvovirus, and parainfluenza virus type 5 in Korean dogs." Korean Journal of Veterinary Research 64, no. 1 (2024): e3. http://dx.doi.org/10.14405/kjvr.20230045.

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Canine distemper virus (CDV), canine adenovirus type 2 (CAV-2), canine parvovirus (CPV), and canine parainfluenza virus 5 (CPIV-5) are the major viral pathogens in dogs. Despite the availability of vaccines for dogs against these four viral pathogens, investigations of antibodies against these pathogens have rarely been reported in South Korea. In this study, we investigated the recent incidence of viral diseases in dogs and conducted sero-surveillance for CDV, CAV-2, CPV, and CPIV-5 in Korean dogs. The most frequently diagnosed canine viral disease in Korean dog samples from 2000 to 2022 was

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Chou, Sunwen, Gail Marousek, and Terry L. Bowlin. "Cyclopropavir Susceptibility of Cytomegalovirus DNA Polymerase Mutants Selected after Antiviral Drug Exposure." Antimicrobial Agents and Chemotherapy 56, no. 1 (2011): 197–201. http://dx.doi.org/10.1128/aac.05559-11.

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ABSTRACTHuman cytomegalovirus (CMV) UL54 DNA polymerase (pol) mutants with known patterns of resistance to current antivirals ganciclovir (GCV), foscarnet (FOS), and cidofovir (CDV) were tested for cyclopropavir (CPV) susceptibility by a standardized reporter-based yield reduction assay. Exonuclease and A987G (region V) mutations at codons commonly associated with dual GCV-CDV resistance in clinical isolates paradoxically conferred increased CPV susceptibility. Various polymerase catalytic region mutations conferring FOS resistance with variable low-grade GCV and CDV cross-resistance also conf

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3

ADASZEK, ŁUKASZ, MARIA PISAREK, MARTA STANIEC, et al. "Use of rapid immunochromatographic tests and PCR for the detection of vaccine viruses (CPV, CDV CAV) in faeces and conjunctival sac swabs of vaccinated dogs." Medycyna Weterynaryjna 79, no. 12 (2023): 644–47. http://dx.doi.org/10.21521/mw.6836.

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The aim of the study was to determine whether the rapid diagnostic CPV Ag (VetExpert), CDV Ag (VetExpert) and CDV/CAV Ag (VetExpert) tests are able to detect the presence of vaccine viruses in faeces and conjunctival swabs (CDV) collected from dogs vaccinated against distemper, parvovirus and Rubarth’s disease. The tested dogs were administered vaccines once, and then faeces and conjunctival sac swabs were collected from all animals on days: 2, 5, 7, 10, 14, 20, 25 after the vaccination for molecular testing and to perform rapid immunochromatographic tests for the detection of CPV, CDV and CAV

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Home, Chandrima, Ajay Bijoor, Yash Veer Bhatnagar, and Abi Tamim Vanak. "Serosurvey of viral pathogens in free-ranging dog populations in the high altitude Trans-Himalayan region." Journal of Threatened Taxa 14, no. 5 (2022): 21025–31. http://dx.doi.org/10.11609/jott.7203.14.5.21025-21031.

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Dogs, as reservoir hosts, have been implicated in the decline of carnivore populations across the globe. We conducted a serosurvey of free-ranging dog populations to assess the population level exposure rates to three viral pathogens, canine parvovirus (CPV), canine distemper virus (CDV) and canine adenovirus (CAV) in a Trans-Himalayan landscape in India that is home to the endangered Snow Leopard. A total of 97 dogs were sampled across six villages as a part of a surgical sterilization campaign during the study period. Samples were tested for IgG antibodies using a table top ELISA kit. Exposu

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5

Dezengrini, Renata, Rudi Weiblen, and Eduardo Furtado Flores. "Soroprevalência das infecções por parvovírus, adenovírus, coronavírus canino e pelo vírus da cinomose em cães de Santa Maria, Rio Grande do Sul, Brasil." Ciência Rural 37, no. 1 (2007): 183–89. http://dx.doi.org/10.1590/s0103-84782007000100029.

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As infecções pelo vírus da cinomose (CDV), por parvovírus (CPV), adenovírus (CAV) e coronavírus (CCoV) são importantes causas de morbidade e de mortalidade em cães de todo o mundo, porém pouco se sabe sobre a sua incidência e prevalência no Brasil. Para determinar-se a prevalência dessas infecções na população canina de Santa Maria, RS, Brasil, amostras de sangue foram coletadas de 817 cães não-vacinados de 14 bairros do município e testadas para a presença de anticorpos específicos. Anticorpos contra o CDV foram detectados em 27,3% (223/817) das amostras, contra o CPV em 68,7% (561/817), cont

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ASLIM, Hatice Pelin, and IRMAK DİK. "Investigation of Distempervirus and Parvovirus Infections in Dogs." International Journal of Veterinary and Animal Research 8, no. 1 (2025): 18–23. https://doi.org/10.5281/zenodo.15109891.

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CDV and CPV are significant viral agents that frequently cause fatal infections in both domestic and wild dogs. In this study, a total of 95 animals, including both healthy individuals and those exhibiting gastrointestinal and neurological symptoms, aged between 6 and 24 months, were serologically examined for CDV and CPV infections using the ELISA test. According to the manufacturer's instructions, the assay range for CDV was specified as 0.7 ng/ml to 200 ng/ml, with a sensitivity value of 0.665 ng/ml. Among the total 95 animals, 48 (50.52%) with good general health had antibody titers rangin

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7

Olson, Pekka, Berndt Klingeborn, and ÅKe Hedhammar. "Serum antibody response to canine parvovirus, canine adenovirus-1, and canine distemper virus in dogs with known status of immunization: Study of dogs in Sweden." American Journal of Veterinary Research 49, no. 9 (1988): 1460–66. https://doi.org/10.2460/ajvr.1988.49.09.1460.

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SUMMARY Serum antibody titers to canine parvovirus (cpv), canine adenovirus-1 (cav-1), and canine distemper virus (cdv) were measured in dogs with known immunization status. The dogs represented 3 groups: nonvaccinated dogs < 12 months old; vaccinated dogs < 12 month old; and adult dogs > 12 months old. For practical reasons, the population from which the specimens were obtained could be considered as free from natural infection with cav-1 and cdv. In nonvaccinated dogs < 12 months old, antibodies against all 3 viruses were measured at the time the dogs were given their first vacci

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8

TRUYEN, U., T. MÜLLER, R. HEIDRICH, K. TACKMANN, and L. E. CARMICHAEL. "Survey on viral pathogens in wild red foxes (Vulpes vulpes) in Germany with emphasis on parvoviruses and analysis of a DNA sequence from a red fox parvovirus." Epidemiology and Infection 121, no. 2 (1998): 433–40. http://dx.doi.org/10.1017/s0950268898001319.

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The seroprevalence of canine parvovirus (CPV), canine distemper virus (CDV), canine adenovirus (CAV) and canine herpesvirus (CHV) infections in red foxes (Vulpes vulpes) was determined in fox sera collected between 1991 and 1995. A total of 500 sera were selected and the seroprevalences were estimated to be 13% (65 of 500 sera) for CPV, 4·4% (17 of 383 sera) for CDV, 3·5% (17 of 485 sera) for CAV, and 0·4% (2 of 485 sera) for CHV, respectively. No statistically significant differences were observed between the two (rural and suburban) areas under study.Parvovirus DNA sequences were amplified f

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9

Sakulwira, K., P. Vanapongtipagorn, A. Theamboonlers, K. Oraveerakul, and Y. Poovorawan. "Prevalence of canine coronavirus and parvovirus infections in dogs with gastroenteritis in Thailand." Veterinární Medicína 48, No. 6 (2012): 163–68. http://dx.doi.org/10.17221/5764-vetmed.

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Canine coronavirus (CCV) and canine parvovirus type 2 (CPV-2) are the causative agents of gastroenteritis in dogs. Seventy fecal samples from dogs with signs of gastroenteritis (vomiting and diarrhea), twenty-five fecal samples from healthy dogs and one CPV-2 vaccine strain were amplified by semi-nested polymerase chain reaction (PCR) and semi-nested reverse transcriptase polymerase chain reaction (RT-PCR), aimed at specifically studying the gene encoding the most abundant capsid protein VP2 of CPV-2 and spike protein of CCV. The specificity of the CCV RT-PCR product was evaluated by sequencin

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10

James, Scott H., Caroll B. Hartline, Emma A. Harden, et al. "Cyclopropavir Inhibits the Normal Function of the Human Cytomegalovirus UL97 Kinase." Antimicrobial Agents and Chemotherapy 55, no. 10 (2011): 4682–91. http://dx.doi.org/10.1128/aac.00571-11.

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ABSTRACTCyclopropavir (CPV) is active against human cytomegalovirus (CMV), as well as both variants of human herpesvirus 6 and human herpesvirus 8. The mechanism of action of CPV against CMV is similar to that of ganciclovir (GCV) in that it is phosphorylated initially by the CMV UL97 kinase, resulting in inhibition of viral DNA synthesis. Resistance to CPV maps to the UL97 kinase but is associated primarily with H520Q mutations and thus retains good antiviral activity against most GCV-resistant isolates. An examination of CMV-infected cultures treated with CPV revealed unusual cell morphology

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11

McCaw, Dudley L., Mark Thompson, Deborah Tate, Anita Bonderer, and Yi-Ju Chen. "Serum distemper virus and parvovirus antibody titers among dogs brought to a veterinary hospital for revaccination." Journal of the American Veterinary Medical Association 213, no. 1 (1998): 72–75. http://dx.doi.org/10.2460/javma.1998.213.01.72.

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Objective To determine serum canine distemper virus (CDV) and canine parvovirus (CPV) antibody titers in healthy dogs brought to a veterinary hospital for revaccination. Design Case series. Animals 122 dogs. Procedure Serum antibody titers were measured by means of hemagglutination inhibition (CPV titers) or serum neutralization (CDV titers) at the time dogs were brought to the hospital for revaccination. All dogs had been vaccinated between 271 and 1,665 days previously. Dogs were grouped by age, breed (purebred vs mixed breed), sex, and weight to determine whether these factors were associat

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12

Chang, Chia-Yu, Wei-Tao Chen, Takeshi Haga, et al. "The Detection and Association of Canine Papillomavirus with Benign and Malignant Skin Lesions in Dogs." Viruses 12, no. 2 (2020): 170. http://dx.doi.org/10.3390/v12020170.

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Papillomavirus (PV) mainly infects the squamous epithelium and may potentially lead to benign or even malignant cutaneous lesions. However, the malignant transforming ability has been identified in several types of PVs. In humans, papillomavirus (HPV) type 16 and 18 are the most prevalent causative agents of cervical cancer. Therefore, vaccines are being developed to protect against these types. For dogs, there have been limited investigations into the association of different canine papillomavirus (CPV) genotypes with malignant lesions. Understanding the high-risk CPV genotype(s) responsible

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13

Shi, Yandi, Feng Long, Kaichuang Shi, et al. "A Quadruplex Reverse Transcription Quantitative Polymerase Chain Reaction for Detecting Canine Coronavirus, Canine Rotavirus, Canine Parvovirus, and Canine Distemper Virus." Microbiology Research 15, no. 2 (2024): 746–61. http://dx.doi.org/10.3390/microbiolres15020049.

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Background: Canine coronavirus (CCoV), canine rotavirus (CRV), canine parvovirus (CPV), and canine distemper virus (CDV) cause gastroenteritis in dogs, and co-infections of these pathogens are common in China. In particular, CCoV and CRV are confirmed to have important zoonotic potential and cause public health issues. It is difficult to diagnose these diseases based only on clinical manifestations and pathological damage. Methods: In this study, four pairs of specific primers and probes targeting the CCoV M, CRV VP7, CPV VP2, and CDV N genes were designed. The reaction conditions, including t

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14

Salgado-Caxito, Marília, Andrea I. Moreno-Switt, Antonio Carlos Paes, et al. "Higher Prevalence of Extended-Spectrum Cephalosporin-Resistant Enterobacterales in Dogs Attended for Enteric Viruses in Brazil Before and After Treatment with Cephalosporins." Antibiotics 10, no. 2 (2021): 122. http://dx.doi.org/10.3390/antibiotics10020122.

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The extensive use of antibiotics is a leading cause for the emergence and spread of antimicrobial resistance (AMR) among dogs. However, the impact of using antibiotics to treat viral infections on AMR remains unknown. In this study, we compared the prevalence of extended-spectrum cephalosporin-resistant Enterobacterales (ESCR-E) between dogs with a suspected infection of canine parvovirus (CPV) and canine distemper (CDV) before and after treatment with third-generation cephalosporins. We found a higher prevalence of ESCR-E faecal carriage in dogs suspected of CPV (37%) and CDV (15%) compared t

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15

Sebbar, Ghizlane, Safae El Azhari, Mourad Drifa, et al. "Production and Evaluation of an Inactivated Adjuvanted Vaccine against Canine Parvovirus in Morocco." Vaccines 12, no. 9 (2024): 995. http://dx.doi.org/10.3390/vaccines12090995.

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The study conducted in Morocco focused on addressing the challenges posed by canine parvovirus (CPV-2) through comprehensive research, vaccine development, and efficacy assessment. Through real-time PCR screening and genotyping, CPV-2 variants were identified circulating in the region. An inactivated vaccine, derived from a CPV-2 strain isolated from a symptomatic dog, was produced and evaluated for safety and efficacy. The vaccine, from the strain named “CaPV M/3-2022”, demonstrated safety in vaccinated puppies, with no adverse reactions observed during the trial period. Efficacy trials showe

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Hübner, Silvia de Oliveira, Felipe Geraldes Pappen, Jerônimo Lopes Ruas, Gilberto D'Ávila Vargas, Geferson Fischer, and Telmo Vidor. "Exposure of pampas fox (Pseudalopex gymnocercus) and crab-eating fox (Cerdocyon thous) from the Southern region of Brazil to Canine distemper virus (CDV), Canine parvovirus (CPV) and Canine coronavirus (CCoV)." Brazilian Archives of Biology and Technology 53, no. 3 (2010): 593–97. http://dx.doi.org/10.1590/s1516-89132010000300012.

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The exposure of 13 Brazilian free-ranging nondomestic canids (five pampas fox - Pseudalopex gymnocercus and eight crab-eating fox -Cerdocyon thous) from Southern region of Brazil, to Canine distemper virus (CDV), canine parvovirus (CPV) and Canine coronavirus (CCoV) was investigated. Antibodies against CDV were detected in 38.5% (5/13) of the samples. There were anti-CDV antibodies in 60% (3/5) of P. gymnocercus and in 25% (2/8) of C. thous. The frequency was higher among the adults and males. Eleven canids (84.6%) presented antibodies against CPV, 80% (4/5) were from P. gymnocercus and 87.5%

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Maia, O. B., A. M. G. Gouveia, A. M. Souza, and E. F. Barbosa. "Avaliação pós-vacinal de lobos guarás Chrysocyon brachyurus (Illiger, 1811) contra os vírus da cinomose e parvovirose caninas." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 51, no. 5 (1999): 415–20. http://dx.doi.org/10.1590/s0102-09351999000500003.

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Este estudo teve como objetivos acompanhar a resposta sorológica pós-vacinal de lobos guarás cativos imunizados contra os vírus da cinomose (CDV) e da parvovirose (CPV) caninas com vacina vírus vivo modificado (VVM) produzida para cães domésticos e determinar um programa de vacinação para a espécie. Amostras de soro foram coletadas de 47 lobos com idades variadas, provenientes de seis zôos. Foram utilizados os testes de soroneutralização (SN) e inibição da hemaglutinação (HI) para mensurar os títulos de anticorpos contra CDV e CPV, respectivamente, sendo testadas 361 amostras para CDV e 353 pa

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Galdioli, L., Y. S. G. Rocha, S. T. O. Stedile, F. Ferreira, and R. C. M. Garcia. "Antibody seroprevalence against canine distemper virus, parvovirus, and adenovirus in dogs from a brazilian animal shelter." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 75, no. 6 (2023): 1076–86. http://dx.doi.org/10.1590/1678-4162-12899.

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ABSTRACT This study aimed to identify and compare the seroprevalence for canine distemper virus (CDV), canine parvovirus (CPV), and canine adenovirus (CAV) between newly admitted and already sheltered dogs. 122 dogs over six months of age and unvaccinated upon admission were sampled and divided into two groups: (A) newly admitted dogs and (B) dogs sheltered for at least two months. Sera were collected to determine IgG antibody titers against CDV, CPV, and CAV. We conducted a descriptive analysis of the samples and a chi-square test to investigate the relationship between potential elements ass

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Evermann, J. F., J. R. Abbott, and S. Han. "Canine Coronavirus-Associated Puppy Mortality without Evidence of Concurrent Canine Parvovirus Infection." Journal of Veterinary Diagnostic Investigation 17, no. 6 (2005): 610–14. http://dx.doi.org/10.1177/104063870501700618.

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This report presents 2 cases in which puppy fatalities were associated with canine coronavirus (CCV), but no evidence of concurrent canine parvovirus (CPV-2) disease was observed. Case 1 involved a 7-week-old, male short-haired Chihuahua, which had become lethargic 24 hours after purchase from a pet store. Within 72 hours, the puppy began to vomit, had diarrhea, and was admitted to the veterinary clinic, where it was placed on IV fluids. The parvovirus Cite® test was negative. The puppy died within 12 hours of admission and was submitted for diagnostic workup. Gross pathology revealed an enter

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Flacke, G., P. Becker, D. Cooper, et al. "An Infectious Disease and Mortality Survey in a Population of Free-Ranging African Wild Dogs and Sympatric Domestic Dogs." International Journal of Biodiversity 2013 (March 31, 2013): 1–9. http://dx.doi.org/10.1155/2013/497623.

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Disease can cause declines in wildlife populations and significantly threaten their survival. Recent expansion of human and domestic animal populations has made wildlife more susceptible to transmission of pathogens from domestic animal hosts. We conducted a pathogen surveillance and mortality survey for the population of African wild dogs (Lycaon pictus) in KwaZulu-Natal (KZN), South Africa, from January 2006–February 2007. Samples were obtained from 24 wild dogs for canine distemper virus (CDV) and canine parvovirus (CPV) serological testing. Data were collected on the presence of CDV, CPV,

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Keyeux, André, Danielle Ochrymowicz-Bemelmans, and André A. Charlier. "Induced Response to Hypercapnia in the Two-Compartment Total Cerebral Blood Volume: Influence on Brain Vascular Reserve and Flow Efficiency." Journal of Cerebral Blood Flow & Metabolism 15, no. 6 (1995): 1121–31. http://dx.doi.org/10.1038/jcbfm.1995.139.

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This study was undertaken to investigate the mechanisms of CBF increase as induced by hypercapnia. It was achieved in anesthetized rats by determining total cerebral blood volume (TCBV), parenchymal blood (CBV), plasma (CPV), erythrocyte (CEV) volumes and cerebral hematocrit (CHct) as well as CBF at about 40, 60, and 80 mm Hg Paco2. TCBV was measured by a noninvasive blood dilution method using [99mTc]pertechnetate. CBV, CPV, and CEV were measured on isolated brain by 125I-serum albumin and 51Cr-erythrocytes. CBF was measured by both [131I/14C]iodoantipyrine and 57Comicrosphere extractions. Th

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Pavana Jyoth, Vanjavaka, Mohana Subramanian Bhaskaran, and Vijay A. K. B. Gundi. "Epidemiology, molecular prevalence and prevention on canine parvovirus in India: A review." Bioinformation 20, no. 5 (2024): 536–46. http://dx.doi.org/10.6026/973206300200536.

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Canine parvovirus (CPV) is a highly contagious and lethal virus that causes severe gastroenteritis and myocarditis in young dogs. In 1978, CPV has rapidly spread worldwide, resulting in outbreaks and high morbidity rates among dog populations. Over a decade, CPV has undergone genetic changes, leading to the emergence of different genotypes (CPV-2a, CPV-2b, and CPV-2c), which have expanded its host range to include cats and tissue culture cells. This review focuses on CPV-2 outbreaks in India from 2010 to 2023, analyzing gene lengths covering 274-438 amino acids in the VP2 gene which are collec

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Inthong, N., S. Kaewmongkol, N. Meekhanon, K. Sirinarumitr, and T. Sirinarumitr. "Dynamic evolution of canine parvovirus in Thailand." February-2020 13, no. 2 (2020): 245–55. http://dx.doi.org/10.14202/vetworld.2020.245-255.

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Background and Aim: According to the previous study, the circulating canine parvovirus (CPV) in Thailand is 2a and 2b. Nowadays, CPV mutants, including CPV-2c, have been identified in many parts of the world. This study aimed to investigate the genetic diversity of the circulating CPV in Thailand. Materials and Methods: Eighty-five CPV-positive fecal samples were obtained from dogs with either acute hemorrhagic diarrhea or diarrhea. The complete VP2 gene of these samples was amplified using VP2 specific primers and polymerase chain reaction (PCR). The obtained full-length VP2 sequences were an

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Cavalli, Alessandra, Vito Martella, Costantina Desario, et al. "Evaluation of the Antigenic Relationships among Canine Parvovirus Type 2 Variants." Clinical and Vaccine Immunology 15, no. 3 (2007): 534–39. http://dx.doi.org/10.1128/cvi.00444-07.

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ABSTRACT The antigenic relationships among the original canine parvovirus type 2 (CPV-2) and the variants CPV-2a, -2b, and -2c were evaluated. Cross-antigenic evaluation revealed clear differences among the CPV variants, which were more appreciable by serum neutralization (SN) than by hemagglutination inhibition. Antigenic differences were found mostly between the original CPV-2 and the variants, but they were also observed among the variants CPV-2a, -2b, and -2c. The variant CPV-2c exhibited a unique antigenic pattern, since it was poorly recognized by the sera of animals immunized with CPV-2

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Nakamura, Masato, Kazuya Nakamura, Takayuki Miyazawa, Yukinobu Tohya, Masami Mochizuki, and Hiroomi Akashi. "Monoclonal Antibodies That Distinguish Antigenic Variants of Canine Parvovirus." Clinical Diagnostic Laboratory Immunology 10, no. 6 (2003): 1085–89. http://dx.doi.org/10.1128/cdli.10.6.1085-1089.2003.

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ABSTRACT Canine parvovirus (CPV) is classified as a member of the feline parvovirus (FPV) subgroup. CPV isolates are divided into three antigenic types: CPV type 2 (CPV-2), CPV-2a, and CPV-2b. Recently, new antigenic types of CPV were isolated from Vietnamese leopard cats and designated CPV-2c(a) or CPV-2c(b). CPV-2c viruses were distinguished from the other antigenic types of the FPV subgroup by the absence of reactivity with several monoclonal antibodies (MAbs). To characterize the antigenicity of CPV-2c, a panel of MAbs against CPV-2c was generated and epitopes recognized by these MAbs were

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Mandawat, Saksham, Rashmi Singh, Nazeer Mohammed, et al. "Comparative Pathophysiology of Canine Parvovirus-2 Variants in Naturally Infected Dogs." Asian Journal of Research in Biochemistry 15, no. 3 (2025): 137–44. https://doi.org/10.9734/ajrb/2025/v15i3395.

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Canine Parvovirus-2 (CPV-2) is a highly lethal virus that affects the canid family. It targets rapidly dividing cells in organs such as the intestines, thymus, lymph nodes, bone marrow, and heart, often resulting in multi-organ failure.This study aimed to evaluate the impact of CPV-2 variants on clinico-physiological, haematological and biochemical parameters in dogs. Two hundred faecal and blood samples from symptomatic dogs, along with 10 healthy controls, were collected at VCC, PGIVER, Jaipur, from July 2024 to December 2024. PCR identified 166 CPV-2 positive cases, comprising 147 CPV-2a, 1

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Dall’Ara, Paola, Stefania Lauzi, Jari Zambarbieri, et al. "Prevalence of Serum Antibody Titers against Core Vaccine Antigens in Italian Dogs." Life 13, no. 2 (2023): 587. http://dx.doi.org/10.3390/life13020587.

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Canine vaccination is the main tool for preventing dangerous and widespread diseases. The strongly recommended (core) dog vaccines are against Canine Parvovirus type 2 (CPV-2), Canine Distemper Virus (CDV), and Canine Adenovirus (CAdV-1), but vaccination protocols should be tailored to dog lifestyles. Vaccination guidelines suggest vaccinating adult dogs no more frequently than every 3 years using modified live (attenuated) vaccines (MLV), thus obtaining a long-lasting (sometimes throughout life) specific protection in many but not all animals. The aim of this study was to determine the actual

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Shivani, Barsain Subhash Verma Rajesh Chahota Prasenjit Dhar and Monika Bhardwaj. "Key strains of canine parvovirus 2 in india: a short communication." Vet Farm Frontier 02, no. 04 (2025): 19–22. https://doi.org/10.5281/zenodo.15362298.

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Canine Parvovirus (CPV) is a highly infectious viral illness that primarily affects dogs, especially puppies aged between six weeks and six months. It is caused by Canine Parvovirus type 2 (CPV-2), which mainly targets the gastrointestinal system and, in some instances, the heart. The virus attacks rapidly dividing cells such as those in the intestinal crypts, bone marrow, and lymphoid tissues, resulting in enteritis, leukopenia, and immunosuppression. Since its discovery, CPV-2 has evolved into multiple strains, contributing to its high virulence. This article focuses on the predominant CPV-2

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Chen, Han, Chengwei Li, Jiri Zemlicka, Brian G. Gentry, Terry L. Bowlin, and Donald M. Coen. "Potency and Stereoselectivity of Cyclopropavir Triphosphate Action on Human Cytomegalovirus DNA Polymerase." Antimicrobial Agents and Chemotherapy 60, no. 7 (2016): 4176–82. http://dx.doi.org/10.1128/aac.00449-16.

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ABSTRACTCyclopropavir (CPV) is a promising antiviral drug against human cytomegalovirus (HCMV). As with ganciclovir (GCV), the current standard for HCMV treatment, activation of CPV requires multiple steps of phosphorylation and is enantioselective. We hypothesized that the resulting CPV triphosphate (CPV-TP) would stereoselectively target HCMV DNA polymerase and terminate DNA synthesis. To test this hypothesis, we synthesized both enantiomers of CPV-TP [(+) and (−)] and investigated their action on HCMV polymerase. Both enantiomers inhibited HCMV polymerase competitively with dGTP, with (+)-C

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Hao, Xiangqi, Yanchao Li, Xiangyu Xiao, Bo Chen, Pei Zhou, and Shoujun Li. "The Changes in Canine Parvovirus Variants over the Years." International Journal of Molecular Sciences 23, no. 19 (2022): 11540. http://dx.doi.org/10.3390/ijms231911540.

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Canine parvovirus (CPV-2) is one of the most important pathogens in dogs, and despite the continual development of vaccines against CPV-2, CPV-2 is still circulating in the canine population. The CPV-2a/2b/2c variant has replaced the original CPV-2 virus and seems to exhibit accelerated transmission. Although CPV-2 infection has been frequently reported, no studies have summarized information of CPV-2 variants currently circulating worldwide. To track the evolution of CPV-2, we downloaded and analyzed all VP2 sequences from the NCBI database (from 1978 to 2022). We found that CPV-2c shows a te

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Hong, Charles, Nicola Decaro, Costantina Desario, et al. "Occurrence of Canine Parvovirus Type 2c in the United States." Journal of Veterinary Diagnostic Investigation 19, no. 5 (2007): 535–39. http://dx.doi.org/10.1177/104063870701900512.

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Canine parvovirus (CPV) type 2 (CPV-2) emerged around 1978 as a major pathogen of dogs worldwide. In the mid-1980s, the original CPV-2 had evolved and was completely replaced by 2 variants, CPV-2a and CPV-2b. In 2000, a new variant of CPV (named CPV-2c) was detected in Italy and now cocirculates with types 2a and 2b in that country. The CPV-2c has also been reported from single outbreaks in Vietnam and Spain. This study was conducted to determine if CPV-2c occurs in the United States. Thirty-three fecal samples were collected from dogs in 16 states between April 2006 and April 2007 and were te

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Zienius, D., R. Lelešius, H. Kavaliauskis, A. Stankevičius, and A. Šalomskas. "Phylogenetic characterization of Canine Parvovirus VP2 partial sequences from symptomatic dogs samples." Polish Journal of Veterinary Sciences 19, no. 1 (2016): 187–96. http://dx.doi.org/10.1515/pjvs-2016-0023.

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Abstract The aim of the present study was to detect canine parvovirus (CPV) from faecal samples of clinically ill domestic dogs by polymerase chain reaction (PCR) followed by VP2 gene partial sequencing and molecular characterization of circulating strains in Lithuania. Eleven clinically and antigen-tested positive dog faecal samples, collected during the period of 2014-2015, were investigated by using PCR. The phylogenetic investigations indicated that the Lithuanian CPV VP2 partial sequences (3025-3706 cds) were closely related and showed 99.0-99.9% identity. All Lithuanian sequences were as

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Vimalan, Yuvachandran Viva, Raja Paramasivam, Parthiban Manoharan, et al. "Genomic Sequence and Phylogenetic analysis of Canine Parvovirus New 2a Variant Strain in Indian Dogs." Indian Journal of Veterinary Sciences & Biotechnology 19, no. 2 (2023): 47–53. http://dx.doi.org/10.48165/ijvsbt.19.2.09.

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In this study, a virulent field canine parvovirus type - 2a variant (CPV-new 2a) strain, ABT/CPV/MVC02, was identified from the faeces of a Dog with severe haemorrhagic gastroenteritis in Chennai, Tamil Nadu, India. The genomic sequence of ABT/CPV/MVC02 (MN661243) shares 99.33% nucleotide identity with those of CPV new 2a variant strains. Based on the VP2 capsid protein amino acid variation (Ser297Ala), the ABT/CPV/MVC02 strain is classified as a new CPV 2a variant strain. Two VP2 mutations Tyr324Ile and Thr440Ala were reported in most of the CPV-2a stains also present in ABT/CPV/MVC02.The phy

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Sen, Soumitra, Md Siddiqur Rahman, Minakshi Nag, Mohummad Muklesur Rahman, Roma Rani Sarker, and SM Lutful Kabir. "Prevalence of canine parvo virus and canine influenza virus infection in dogs in Dhaka, Mymensingh, Feni and Chittagong districts of Bangladesh." Asian Journal of Medical and Biological Research 2, no. 1 (2016): 138–42. http://dx.doi.org/10.3329/ajmbr.v2i1.27579.

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Canine parvovirus (CPV) and canine influenza virus (CIV) are highly contagious virus infecting members of the canine family including dogs, coyotes, foxes and wolves. The research work was carried out to determine the prevalence of CPV and CIV in dogs (stray and pet dogs) in Dhaka, Mymensingh, Feni and Chittagong Districts by using Rapigen CPV and CIV Ag test kit. Fecal samples were collected from 50 dogs of different age and sex from different spots of Dhaka and Chittagong District. Nasal fluid samples were collected from 50 dogs of different age and sex from different spots. The samples were

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Horecka, Kevin, Nipuni Ratnayaka, and Elizabeth A. Davis. "Changes in Mass Treatment of the Canine Parvovirus ICU Population in Relation to Public Policy Changes during the COVID-19 Pandemic." Viruses 12, no. 12 (2020): 1419. http://dx.doi.org/10.3390/v12121419.

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Previous work has indicated that canine parvovirus (CPV) prevalence in the Central Texas region may follow yearly, periodic patterns. The peak in CPV infection rates occurs during the summer months of May and June, marking a distinct “CPV season”. We hypothesized that human activity contributes to these seasonal changes in CPV infections. The COVID-19 pandemic resulted in drastic changes in human behavior which happened to synchronize with the CPV season in Central Texas, providing a unique opportunity with which to assess whether these society-level behavioral changes result in appreciable ch

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Giraldo-Ramirez, Sebastián, Santiago Rendon-Marin, and Julián Ruiz-Saenz. "Phylogenetic, Evolutionary and Structural Analysis of Canine Parvovirus (CPV-2) Antigenic Variants Circulating in Colombia." Viruses 12, no. 5 (2020): 500. http://dx.doi.org/10.3390/v12050500.

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Canine parvovirus (CPV-2) is the causative agent of haemorrhagic gastroenteritis in canids. Three antigenic variants—CPV-2a, CPV-2b and CPV-2c—have been described, which are determined by variations at residue 426 of the VP2 capsid protein. In Colombia, the CPV-2a and CPV-2b antigenic variants have previously been reported through partial VP2 sequencing. Mutations at residues Asn428Asp and Ala514Ser of variant CPV-2a were detected, implying the appearance of a possible new CPV-2a variant in Colombia. The purpose of the present study was to characterise the full VP2 capsid protein in samples fr

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Astawa, I. Nyoman Mantik, and Gusti Ayu Yuniati Kencana. "Antibody Response of Mice to Bali Isolate of Canine Parvovirus Propagated in Madin-Darby Canine Kidney Cell Culture." World's Veterinary Journal 14, no. 3 (2024): 355–65. http://dx.doi.org/10.54203/scil.2024.wvj42.

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Canine parvovirus (CPV) infection is still common among dogs, leading to severe disease with high mortality. The potential of a local isolate of CPV as an effective vaccine to prevent the disease warrants investigation. This study aimed to determine the antibody response in mice against a Bali isolate of CPV propagated in the Madin-Darby Canine Kidney (MDCK) cell culture. The virus was purified using polyethylene glycol (PEG)-6000 and mixed with an Aluminum hydroxide adjuvant. Fifteen 7-week female mice were divided into three treatment groups: treatment group 1 (PEG-purified virus and Adjuvan

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Oblavatckii, Dmitrii V., and Svetlana A. Boldueva. "Characteristics of clinical signs, laboratory and instrumental examinations in various mechanisms of development of type 2 myocardial infarction." CardioSomatics 12, no. 3 (2021): 132–38. http://dx.doi.org/10.17816/22217185.2021.3.201042.

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Aim. To identify different pathogenetic variants of myocardial infarction type 2 (MI-2). Material and methods. Reviewed 4168 cases of MI admitted in multidisciplinary hospital for 10 years. 353 patients met the criteria for MI-2 without signs of coronary atherothrombosis (CA). In the study group, the features of clinical and laboratory-instrumental manifestations were evaluated. Results. Cases of IM-2 were subdivided into 4 clinical-pathogenic variants (CPV): 1-CPV developed due an increasing in myocardial oxygen demand; 2-CPV, arising from a decrease in the supply of oxygen; 3-CPV

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Tsai, Ching-Shu, Chung-Ying Lin, Ray C. Hsiao, and Cheng-Fang Yen. "Psychometric Properties of the Chinese Version of the Child-to-Parent Violence Questionnaire in Adolescents with Attention-Deficit/Hyperactivity Disorder." Children 12, no. 4 (2025): 408. https://doi.org/10.3390/children12040408.

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Purpose: Child-to-parent violence (CPV) is a major concern for adolescents with attention-deficit/hyperactivity disorder (ADHD). The Child-to-Parent Violence Questionnaire (CPV-Q) is a valid instrument for assessing a wide variety of CPV behaviors and the reasons; however, the psychometric properties of the Chinese version of CPV-Q (C-CPV-Q) in adolescents with ADHD have not been examined yet. This study examined the psychometric properties of both child and parent versions of C-CPV-Q in adolescents with ADHD. Participants and Methods: In total, 247 adolescents with ADHD and their parents part

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Jantafong, Tippawan, Sakchai Ruenphet, Harold R. Garner, and Krit Ritthipichai. "Tracing the Genetic Evolution of Canine Parvovirus Type 2 (CPV-2) in Thailand." Pathogens 11, no. 12 (2022): 1460. http://dx.doi.org/10.3390/pathogens11121460.

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Canine parvovirus type 2 (CPV-2) is responsible for hemorrhagic gastroenteritis in dogs worldwide. High genomic substitution rates in CPV-2 contribute to the progressive emergence of novel variants with increased ability to evade the host immune response. Three studies have analyzed the genomic mutations of CPV-2 variants in Thailand. These investigations were independently conducted at different timepoints. Thus, a retrospective integrated analysis of CPV-2 genomic mutations has not been fully performed. Our study aimed at evaluating the evolutionary changes in CPV-2 in Thailand from 2003 to

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Carrino, Marilena, Luca Tassoni, Mery Campalto, et al. "Molecular Investigation of Recent Canine Parvovirus-2 (CPV-2) in Italy Revealed Distinct Clustering." Viruses 14, no. 5 (2022): 917. http://dx.doi.org/10.3390/v14050917.

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Canine parvovirus Type 2 (CPV-2) is a worldwide distributed virus considered the major cause of viral gastroenteritis in dogs. Studies on Italian CPV-2 are restricted to viruses circulating until 2017. Only one study provided more updated information on CPV-2 but was limited to the Sicily region. No information regarding the circulation and genetic characteristics of CPV-2 in Northeast Italy has been made available since 2015. The present study investigated the genetic characteristics of CPV-2 circulating in the dog population of Northeast Italy between 2013 and 2019. The VP2 gene of 67 CPV-2

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Gainor, Kerry, April Bowen, Pompei Bolfa, Andrea Peda, Yashpal S. Malik, and Souvik Ghosh. "Molecular Investigation of Canine Parvovirus-2 (CPV-2) Outbreak in Nevis Island: Analysis of the Nearly Complete Genomes of CPV-2 Strains from the Caribbean Region." Viruses 13, no. 6 (2021): 1083. http://dx.doi.org/10.3390/v13061083.

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To date, there is a dearth of information on canine parvovirus-2 (CPV-2) from the Caribbean region. During August–October 2020, the veterinary clinic on the Caribbean island of Nevis reported 64 household dogs with CPV-2-like clinical signs (hemorrhagic/non-hemorrhagic diarrhea and vomiting), of which 27 animals died. Rectal swabs/fecal samples were obtained from 43 dogs. A total of 39 of the 43 dogs tested positive for CPV-2 antigen and/or DNA, while 4 samples, negative for CPV-2 antigen, were not available for PCR. Among the 21 untested dogs, 15 had CPV-2 positive littermates. Analysis of th

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Gentry, Brian G., Jeremy P. Kamil, Donald M. Coen, Jiri Zemlicka, and John C. Drach. "Stereoselective Phosphorylation of Cyclopropavir by pUL97 and Competitive Inhibition by Maribavir." Antimicrobial Agents and Chemotherapy 54, no. 8 (2010): 3093–98. http://dx.doi.org/10.1128/aac.00468-10.

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ABSTRACT Human cytomegalovirus (HCMV) is a widespread pathogen that can cause severe disease in immunologically immature and immunocompromised individuals. Cyclopropavir (CPV) is a guanine nucleoside analog active against human and murine cytomegaloviruses in cell culture and efficacious in mice by oral administration. Previous studies established that the mechanism of action of CPV involves inhibition of viral DNA synthesis. Based upon this action and the structural similarity of CPV to ganciclovir (GCV), we hypothesized that CPV must be phosphorylated to a triphosphate to inhibit HCMV DNA sy

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Pereira, Nicole Assis, Telma Alves Monez, César Augusto Dinóla Pereira, Leonardo José Richtzenhain, and Edison Luiz Durigon. "Caracterização antigênica de isolados de parvovirus canino do Brasil utilizando monoclonais específicos." Brazilian Journal of Veterinary Research and Animal Science 45, no. 5 (2008): 385. http://dx.doi.org/10.11606/issn.1678-4456.bjvras.2008.26680.

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O Parvovírus Canino (CPV) é um patógeno emergente em cães, isolado pela primeira vez em 1978, nos Estados Unidos. A amostra original de 1978 foi designada CPV tipo 2 (CPV-2). Entretanto, análises de isolados de CPV dos Estados Unidos, por enzimas de restrição e anticorpos monoclonais demonstraram que cerca de 1979, uma amostra variante, designada CPV tipo 2a (CPV-2a) tornou-se prevalente. Subseqüentemente, uma nova amostra antigênica, designada CPV tipo 2b (CPV-2b) também foi observada por análises de isolados de CPV de várias partes do mundo, embora a proporção fosse diferente entre os países

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Hyeon, Lee-Sang, Dong-Kun Yang, Eun-Ju Kim, Yu-Ri Park, Hye Jeong Lee, and Bang-Hun Hyun. "Evaluation of commercial immunochromatography test kits for diagnosing canine parvovirus." Korean Journal of Veterinary Research 63, no. 2 (2023): e19. http://dx.doi.org/10.14405/kjvr.20230016.

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Rapid immunochromatography test (RICT) kits are commonly used for the diagnosis of canine parvovirus (CPV) because of their rapid turnaround time, simplicity, and ease of use. However, the potential for cross-reactivity and low sensitivity can yield false-positive or false-negative results. There are 4 genotypes of CPV. Therefore, evaluating the performance and reliability of RICT kits for CPV detection is essential to ensure accurate diagnosis for appropriate treatment. In this study, we evaluated the performance of commercial RICT kits in the diagnosis of all CPV genotypes. The cross-reactiv

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Wen, Jiexia, Sumin Pan, Shuang Liang, et al. "Soluble Form of Canine Transferrin Receptor Inhibits Canine Parvovirus InfectionIn VitroandIn Vivo." BioMed Research International 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/172479.

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Canine parvovirus (CPV) disease is an acute, highly infectious disease threatening the dog-raising industry. So far there are no effective therapeutic strategies to control this disease. Although the canine transferrin receptor (TfR) was identified as a receptor for CPV infection, whether extracellular domain of TfR (called soluble TfR (sTfR)) possesses anti-CPV activities remains elusive. Here, we used the recombinant sTfR prepared from HEK293T cells with codon-optimized gene structure to investigate its anti-CPV activity bothin vitroandin vivo. Our results indicated that codon optimization c

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Jinadasa, Rasika, Sayani Ghosh, Simon Hills, et al. "Genomic Variability of Canine Parvoviruses from a Selected Population of Dogs and Cats in Sri Lanka." Pathogens 10, no. 9 (2021): 1102. http://dx.doi.org/10.3390/pathogens10091102.

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The aim of the study was to identify canine parvovirus type 2 (CPV-2) subtypes circulating among a selected population of domestic dogs and cats in Sri Lanka and to investigate the evolutionary patterns among Sri Lankan viruses in the context of contemporary global CPV-2 sequences. Altogether, 40/61 (65.6%) samples tested were positive for CPV-2 DNA, including 31/48 (64.6%) dogs and 9/13 (69%) cats. All three subtypes (CPV-2a, CPV-2b and CPV-2c) were detected, with CPV-2a being most common. International median joining haplotype network of 291 CPV-2 sequences suggested that there was little ba

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Maganga, Gael Darren, Ingrid Labouba, Serda Zita Milendz Ikapi, et al. "Molecular Characterization of Canine Parvovirus Variants CPV-2a and CPV-2c, Associated with Vaccinated Dogs at Libreville, Gabon." Viruses 15, no. 5 (2023): 1169. http://dx.doi.org/10.3390/v15051169.

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The first detection of canine parvovirus type-2 (CPV-2) was in the early 1970s, when it was known to cause severe gastroenteritis in dogs. However, it has evolved over the years into CPV-2a within 2 years, into CPV-2b after 14 years, into CPV-2c after 16 years and more recently CPV-2a-, 2b- and 2c-like variants reported in 2019, with a global distribution. Reports on the molecular epidemiology of this virus are missing in most African countries. The report of clinical cases among vaccinated dogs in Libreville in Gabon triggered the execution of this study. The objective of this study was to ch

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Niedringhaus, Kevin D., Justin D. Brown, Mark A. Ternent, Christopher A. Cleveland, and Michael J. Yabsley. "A Serosurvey of Multiple Pathogens in American Black Bears (Ursus americanus) in Pennsylvania, USA Indicates a Lack of Association with Sarcoptic Mange." Veterinary Sciences 6, no. 4 (2019): 75. http://dx.doi.org/10.3390/vetsci6040075.

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Infectious diseases, particularly of wildlife, are intrinsically linked to human and domestic animal health. Reports of sarcoptic mange in black bears (Ursus americanus) are increasing in multiple states in the USA and while the reason is unknown, mange in other species has been associated with immunosuppression from multiple causes. Serum from bears across Pennsylvania were collected to determine the seroprevalence of five pathogens important for animal and/or human health: Canine distemper virus (CDV), canine parvovirus (CPV), canine adenovirus-1 (CAV), Toxoplasma gondii, and Trichinella sp.

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Giuseppa, Purpari, Mira Francesco, Di Bella Santina, Di Pietro Simona, Giudice Elisabetta, and Guercio Annalisa. "Investigation on Canine parvovirus circulation in dogs from Sicily (Italy) by biomolecular assay." Acta Veterinaria 68, no. 1 (2018): 80–94. http://dx.doi.org/10.2478/acve-2018-0007.

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Abstract Canine parvovirus type-2 (CPV-2) is a DNA virus that causes a very common worldwide diffused infectious disease in dogs. Since its appearance, the CPV-2 evolved generating novel genetic and antigenic variants (CPV-2a/2b/2c) which are distributed throughout the world. In the present study, the frequency of CPV-2 in a canine population in Sicily (Italy) was investigated, using a polymerase chain reaction (PCR) for a fragment of the VP2 gene. Out of a total of 673 samples from 370 dogs, submitted to the laboratory from July 2009 to August 2015, 265 samples (39.38%) were positive and thes

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