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Relevant bibliographies by topics / CYP2C8*5 Polymorphism in Ghana

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Academic literature on the topic 'CYP2C8*5 Polymorphism in Ghana'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "CYP2C8*5 Polymorphism in Ghana"

1

Charles, Brown, Larbie Christopher, and Selorm Yao Amuzu Dominic. "Prevalence of the Genetic Mutation CYP2C8*5 in Selected Ethnic Groups in Southern Ghana." International Journal of Biochemistry Research & Review 12, no. 3 (2016): 1–9. https://doi.org/10.9734/IJBCRR/2016/25680.

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Aim: The study determined prevalence of clinically relevant CYP2C8*5 polymorphism in 80 unrelated individuals, from selected ethnic groups in Southern Ghana. Medical history on adverse drug reactions of the subjects and level of dependencyon drugs metabolized by CYP2C8 enzyme was obtained by questionnaire. Allele Specific-PCR analyses were used to genotype CYP2C8*5 alleles in the study subjects. Results: Allelic frequency for CYP2C8*5was 83.75% which was statistically significant (p<0.05). There was no significant difference (p> 0.05) in the prevalence of CYP2C8*5allele within the ethnic

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2

Milovanovic, DD, JR Milovanovic, M. Radovanovic, et al. "The influence of CYP2C8*3 on carbamazepine serum concentration in epileptic pediatric patients." Balkan Journal of Medical Genetics 19, no. 1 (2016): 21–28. http://dx.doi.org/10.1515/bjmg-2016-0003.

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AbstractThe aim of the present study was to investigate the distribution of CYP2C8 variants *3 and *5, as well as their effect on carbamazepine pharmacokinetic properties, in 40 epileptic pediatric patients on carbamazepine treatment. Genotyping was conducted using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and allele-specific (AS)-PCR methods, and steady-state carbamazepine plasma concentrations were determined by high performance liquid chromatography (HPLC). The CYP2C8 *3 and *5 polymorphisms were found at frequencies of 17.5 and 0.0%, respectively. After

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3

Ximenes, Rosana Christine Cavalcanti, Bashir Ahmed, Vahid Nikoui, Khuseyn Egamnazarov, and Muhammad Imran Khan. "Polymorphisms in CYP2C8 gene in Pakistani population and their frequencies in various ethnic groups." Molecular Medicine Communications 1, no. 1 (2021): 03–16. http://dx.doi.org/10.55627/mmc.001.01.0016.

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Cytochrome P4502C8 represents 7% of the hepatic cytochrome system and metabolizes around 5% of drugs in phase I processes. It also plays a significant role in the metabolism of endogenous compounds. More than 20 single nucleotide polymorphisms (SNPs) have been reported, mainly in exon 3, 5, and 8. Some of the SNP’s lead to decreased enzyme activity and may have impact on drug metabolism. This research study aims to determine the frequencies of the most common SNPs of the CYP2C8 gene (CYP2C8*2, *3, *4) in the Pakistani population. A cross-sectional study consisting of 391 healthy humans was con

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4

Denisenko, N. P., Sh P. Abdullaev, K. A. Akmalova, et al. "Structure of the distribution of genetic determinants of the efficacy and safety of non-steroidal anti-inflammatory drugs in the Russian population: focus on CYP2C8, PTGS1 and PTGS2." Modern Rheumatology Journal 16, no. 1 (2022): 60–67. http://dx.doi.org/10.14412/1996-7012-2022-1-60-67.

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The efficacy and safety of non-steroidal anti-inflammatory drugs (NSAIDs) may be determined by the polymorphic nature of the CYP2C8, PTGS1 and PTGS2 genes.Objective: to analyze the nature of the distribution of CYP2C8*3 (rs10509681), CYP2C8*3 (rs11572080), PTGS1 (rs10306135), PTGS1 (rs12353214) and PTGS2 (rs20417) among residents of the North Caucasus.Patients and methods. The study involved 676 volunteers from Russian, Balkar, Kabardian and Ossetian ethnic groups. Carriage of polymorphic markers CYP2C8, PTGS1 and PTGS2 was determined using real-time polymerase chain reaction.Results and discu

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5

Niemi, M. "Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide." Clinical Pharmacology & Therapeutics 74, no. 4 (2003): 380–87. http://dx.doi.org/10.1016/s0009-9236(03)00228-5.

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6

Brown, Charles, Christopher Larbie, and Dominic Amuzu. "Prevalence of the Genetic Mutation CYP2C8*5 in Selected Ethnic Groups in Southern Ghana." International Journal of Biochemistry Research & Review 12, no. 3 (2016): 1–9. http://dx.doi.org/10.9734/ijbcrr/2016/25680.

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7

Pereira de Sena, Luann Wendel, Hellen Thais Fuzii, Fabiola Elizabeth Villanova, et al. "Influence of CYP2C8 Polymorphism on the Exposure to Chloroquine in Patients with Malaria by Plasmodium vivax—A Preliminary Study." International Journal of Environmental Research and Public Health 22, no. 3 (2025): 336. https://doi.org/10.3390/ijerph22030336.

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Aim: To assess the impact of the CYP2C82 polymorphism on chloroquine and desethylchloroquine concentrations in patients with malaria caused by P. vivax. Methods: A prospective study was conducted on patients with malaria in an endemic area of the Amazon basin. Liquid chromatography was employed to measure the levels of chloroquine and desethylchloroquine, while molecular methods estimated the frequency of the CYP2C82 variant. Results: This study revealed that plasma levels of chloroquine were higher in patients with the CYP2C82 polymorphism compared to those without this variant. The differenc

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8

Patil, Madhavi N., Kailas D. Datkhile, Anand K. Gudur, Rashmi A. Gudur, and Satish R. Patil. "Single-nucleotide polymorphism in CYP1A1, CYP1B1, CYP2B6, CYP2C8, and CYP2C9 genes and their association with gastrointestinal cancer: A hospital-based case-control study." Journal of Cancer Research and Therapeutics 20, no. 1 (2023): 216–23. http://dx.doi.org/10.4103/jcrt.jcrt_294_22.

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Background: Cytochrome P450 (CYP) comprises a group of phase-I metabolizing enzymes that are important in xenobiotics metabolism. Genetic polymorphism of CYPs has been comprehensively studied for their association with a range of diseases. In this study, we assessed single-nucleotide polymorphism (SNP) of CYP1A, CYP1B, CYP2B, and CYP2C and their role in gastrointestinal (GI) cancer susceptibility in the rural population of Maharashtra. Materials and Methods: In this hospital-based case-control study, the association of polymorphism of CYP genes was studied by the polymerase chain reaction-rest

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9

Lundtoft, Christian, Anthony Afum-Adjei Awuah, Alptekin Güler та ін. "An IL7RA exon 5 polymorphism is associated with impaired IL-7Rα splicing and protection against tuberculosis in Ghana". Genes & Immunity 20, № 6 (2018): 514–19. http://dx.doi.org/10.1038/s41435-018-0049-5.

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10

Zhiryakova, A. S., N. P. Denisenko, S. N. Tuchkova, et al. "Pharmacogenetic aspects of the efficacy of nonsteroidal anti-inflammatory drugs and opioid analgesics for postoperative pain relief after total joint arthroplasty." Modern Rheumatology Journal 19, no. 3 (2025): 40–47. https://doi.org/10.14412/1996-7012-2025-3-40-47.

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Objective: to investigate possible associations between genetic, clinical, laboratory, and demographic parameters and the level of pain in the early postoperative (p/o) period, the need for opioid analgesics, and gastrointestinal symptoms in patients who underwent primary total knee (TKR) or hip replacement (THR).Material and methods. Sixty-one patients hospitalized for THR or TKR were included in the study. P/o pain relief was achieved using nonsteroidal anti-inflammatory drugs (NSAIDs) – ketoprofen or ketorolac – with tramadol prescribed "on demand." Pain was assessed in all patients using t

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