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Relevant bibliographies by topics / CYP2CP

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Academic literature on the topic 'CYP2CP'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "CYP2CP"

1

Swar Aldahab, Azza A. M. H., Abdalla O. Elkhawad, Ahmed S. A. Elsayed, and Hanan B. Eltahir. "Mean Stable Warfarin Doses Versus CYP2C9*2 and VKORC11639G>A Genotypes in Sudanese Population." Asian Journal of Pharmaceutical Research and Health Care 9, no. 1 (2016): 34. http://dx.doi.org/10.18311/ajprhc/0/7708.

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Warfarin is a potent anticoagulant with a confirmed effectiveness when anticoagulation targets are attained, an issue, that is troublesome to reach due to the fact that warfarin has a narrow therapeutic index (NTI), that means they have a narrow window between their effective doses and those at which they produce adverse toxic effects. However, oral anticoagulation throughout genetics recommended a genotype guided dosing, but is it favourable over clinical based dosing? Objectives: To analyze the mean stable warfarin doses attained clinically within CYP2C9*2 and VKORC11639G&gt;A wild-type

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Swar Aldahab, Azza A. M. H., Abdalla O. Elkhawad, Ahmed S. A. Elsayed, and Hanan B. Eltahir. "Mean Stable Warfarin Doses Versus CYP2C9*2 and VKORC11639G>A Genotypes in Sudanese Population." Asian Journal of Pharmaceutical Research and Health Care 9, no. 1 (2016): 34. http://dx.doi.org/10.18311/ajprhc/2017/7708.

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Warfarin is a potent anticoagulant with a confirmed effectiveness when anticoagulation targets are attained, an issue, that is troublesome to reach due to the fact that warfarin has a narrow therapeutic index (NTI), that means they have a narrow window between their effective doses and those at which they produce adverse toxic effects. However, oral anticoagulation throughout genetics recommended a genotype guided dosing, but is it favourable over clinical based dosing? Objectives: To analyze the mean stable warfarin doses attained clinically within CYP2C9*2 and VKORC11639G&gt;A wild-type

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Chowdhury, MSI Tipu, Md Fakhrul Islam Khaled, Sadia Sultana, et al. "Validation of Pharmacogenetic Testing Before Initiation of Warfarin Therapy." University Heart Journal 15, no. 2 (2019): 74–78. http://dx.doi.org/10.3329/uhj.v15i2.42665.

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Warfarin is an oral anticoagulant used to prevent or treat clotting disorders associated with venous thrombosis, pulmonary embolism, atrial fibrilation, cardiac valve replacement, stroke and acute myocardial infarction. It is a vitamin K antagonist composed of S- and R- isomers. The more potent S-warfarin is metabolized by cytochrome 450 isoenzyme 2C9 (CYP2C9), encoded by CYP2C9 gene. Warfarin exerts its anticoagulants effect by inhibitingits target enzyme vitamin K epoxide reductase (VKOR), encoded by vitamin K epoxide reductase subunit 1 (VKOR1) gene. Genetic variation in the CYP2C9 and VKOR

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Ren, Xiaojing, Yuanyuan Ji, Xuhua Jiang, and Xun Qi. "Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma." BioMed Research International 2018 (July 25, 2018): 1–9. http://dx.doi.org/10.1155/2018/5859415.

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Objective. This study aimed to evaluate the links between CYP450 family genes in tumor tissues and hepatocellular carcinoma (HCC) outcomes.Methods. Gene Expression Omnibus (GEO) databases GSE14520 and GSE36376 were used to identify differential expressed CYP450 genes between tumor and nontumor tissues and related to HCC clinicopathological features and survivals.Results. Seven CYP450 genes including CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2E1, CYP3A4, and CYP4A11 were downregulated in tumor tissues, which were validated in both GSE14520 and GSE36376. HCC patients with CYP2A6 and CYP2C8 low levels i

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Niwa, Toshiro, and Yurie Imagawa. "Substrate Specificity of Human Cytochrome P450 (CYP) 2C Subfamily and Effect of Azole Antifungal Agents on CYP2C8." Journal of Pharmacy & Pharmaceutical Sciences 19, no. 4 (2016): 423. http://dx.doi.org/10.18433/j31s53.

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PURPOSE: The metabolic activities of aminopyrine N-demethylation and tolbutamide methylhydroxylation by the human hepatic cytochrome P450 (P450 or CYP) 2C subfamily were compared and the effects of azole antifungal agent on the drug-metabolizing activity of CYP2C8 were investigated. METHODS: Aminopyrine N-demethylation and tolbutamide methylhydroxylation by CYP2C8, CYP2C9, and CYP2C19 were determined by the previous reported methods. The effects of five azole antifungal agents, fluconazole, itraconazole, ketoconazole, miconazole, and voriconazole, on the aminopyrine N-demethylation activity by

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Chamboko, Chiratidzo R., Wayde Veldman, Rolland Bantar Tata, Birgit Schoeberl, and Özlem Tastan Bishop. "Human Cytochrome P450 1, 2, 3 Families as Pharmacogenes with Emphases on Their Antimalarial and Antituberculosis Drugs and Prevalent African Alleles." International Journal of Molecular Sciences 24, no. 4 (2023): 3383. http://dx.doi.org/10.3390/ijms24043383.

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Precision medicine gives individuals tailored medical treatment, with the genotype determining the therapeutic strategy, the appropriate dosage, and the likelihood of benefit or toxicity. Cytochrome P450 (CYP) enzyme families 1, 2, and 3 play a pivotal role in eliminating most drugs. Factors that affect CYP function and expression have a major impact on treatment outcomes. Therefore, polymorphisms of these enzymes result in alleles with diverse enzymatic activity and drug metabolism phenotypes. Africa has the highest CYP genetic diversity and also the highest burden of malaria and tuberculosis

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Zhang, Jiang-Wei, Yong Liu, Jie Cheng, et al. "Inhibition of Human Liver Cytochrome P450 by Star Fruit Juice." Journal of Pharmacy & Pharmaceutical Sciences 10, no. 4 (2007): 496. http://dx.doi.org/10.18433/j30593.

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Purpose. To examine the inhibitory effects of star fruit (Averrhoa carambola) juice towards seven major cytochrome P450 (CYP) isoforms and NADPH-cytochrome P450 reductase (CPR). Methods. The inhibitory effects of star fruit juice (0.5 to 5%, v/v) against the activities of seven CYP isoforms including CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4 and CPR were examined in human liver microsomes. To identify time-dependent inhibition, star fruit juice (2.5%, v/v) was preincubated with microsomes and a NADPH-generating system for 0-15 min, and then the extent of inhibition towards seven C

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Pan, Yan, Kai Hung Tiong, Badrul Amini Abd-Rashid, et al. "Effect of eurycomanone on cytochrome P450 isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 in vitro." Journal of Natural Medicines 68, no. 2 (2013): 402–6. http://dx.doi.org/10.1007/s11418-013-0794-8.

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RanakishorPelluri*, Panguluri Haripriya Mantri Satyavathi V. Lakshmi Prasanna Shaik SeshmaIfthulla P.SrinivasaBabu. "WARFARIN DOSAGE ADJUSTMENT IN PATIENTS WITH GENETIC VARIABILITY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 488–91. https://doi.org/10.5281/zenodo.1036431.

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Warfarin is a potent drug that when used judiciously and monitored closely, leads to substantial reductions in morbidity and mortality from thromboembolic events. However, even with careful monitoring, initiation of warfarin dosing is associated with highly variable responses between individuals and challenges achieving and maintaining levels within the narrow therapeutic range that can lead to adverse drug events. Genetic factors most correlated with warfarin dose requirements are variations in the genes encoding the enzymes cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKOR).

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Halling, Jónrit, Maria S. Petersen, Per Damkier, et al. "Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population." European Journal of Clinical Pharmacology 61, no. 7 (2005): 491–97. http://dx.doi.org/10.1007/s00228-005-0938-1.

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Dissertations / Theses on the topic "CYP2CP"

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Wang, Haoyi. "ORGANIZATION AND EVOLUTION OF THE CYP2A-T GENE SUBFAMILY CLUSTER IN RODENTS, AND A COMPARISON TO THE SYNTENIC HUMAN CLUSTER." Miami University / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=miami1050615100.

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Wang, Jue. "Regulation and polymorphism of CYP2A6, CYP2B6 and CYP2E1 : functional and clinical aspects /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-650-6/.

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Nowak, Maciej P. "Comparison of polymorphic CYP2D6, CYP2C19 and CYP2A6 in Canadian Native Indian, Caucasian and Chinese populations." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29327.pdf.

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Prado, Carolina Martins do. "Desenvolvimento de metodologia para a determinação dos genótipos principais dos genes CYP2D6, CYP2C19 e CYP2C9: aplicação na farmacogenética." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-30042010-093536/.

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As enzimas CYP2D6, CYP2C19 e CYP2C9 são responsáveis pelo metabolismo de aproximadamente metade dos 200 medicamentos mais prescritos nos EUA. Padronizamos ensaios de genotipagem baseados na discriminação alélica com o sistema TaqMan® em 198 indivíduos. Para o gene CYP2D6, os alelos *1 e *2 foram os mais freqüentes, seguidos pelos alelos *4, *41, *35, *17, *5, *10, *6, *29 e *9. Desenvolvemos também uma nova metodologia para a determinação do número de cópias do gene CYP2D6. Para o gene CYP2C19, o alelo *1 foi o mais frequente, seguido pelos alelos *17, *2 e *3. Nosso estudo foi o primeiro a de

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Müller, Gunnar. "Bedeutung der genetischen Polymorphismen in den Enzymen CYP2D6, CYP2C19 und CYP2C9 für Pharmakokinetik der trizyklischen Antidepressiva Doxepin und Trimipramin." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15377.

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Mehrere Studien wiesen eine Beteiligung der Enzyme CYP2D6, CYP2C19 und CYP2C9 am Metabolismus von trizyklischen Antidepressiva nach. Wir untersuchten die Auswirkungen genetischer Polymorphismen dieser Enzyme auf die Pharmakokinetik von E-, Z-Doxepin und Trimipramin beim Menschen. Eine einzelne orale Dosis von jeweils 75 mg Trimipramin und Doxepin wurde 42 gesunden Probanden verabreicht, die als Schnell- (EM), Intermediär- (IM) und Langsammetabolisierer (PM) von CYP2D6- und CYP2C19-Substraten und als Langsammetabolisierer mit dem CYP2C9-Genotyp *3/*3 genotypisiert worden waren. Die Substrate so

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Gültepe, Şenol [Verfasser], Jürgen [Akademischer Betreuer] Brockmöller, Patricia [Akademischer Betreuer] Virsik-köpp, and Dirk [Akademischer Betreuer] Vollmann. "Auswirkungen von CYP2D6-, CYP2C9- und CYP2C19-Polymorphismen auf Pharmakokinetik und Wirkungen von Carvedilol / Şenol Gültepe. Gutachter: Patricia Virsik-Köpp ; Dirk Vollmann. Betreuer: Jürgen Brockmöller." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2011. http://d-nb.info/1044045728/34.

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Lorberg, Caroline. "Bedeutung von Cytochrom-P450-Polymorphismen für Verlauf, Erfolg und Nebenwirkungen der Therapie mit Antidepressiva." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15375.

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Im Bereich der medikamentösen antidepressiven Therapie ist die Bedeutung von erblichen Polymorphismen arzneistoffmetabolisierender Enzyme bereits in vielen Studien untersucht und gezeigt worden. Die meisten Antidepressiva werden über polymorphe Cytochrom-P450-Enzyme verstoffwechselt. Diese Arbeit befasst sich mit der Fragestellung, ob die Häufigkeitsverteilung der CYP2D6-, CYP2C19- und CYP2C9-Allele in der an Depression erkrankten Studienpopulation sich von der in der Normalbevölkerung unterscheidet und ob Veränderungen in der Pharmakokinetik, wie sie durch Cytochrom-P450-Polymorphismen verurs

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Uwimana, Eric. "Probing the PCB metabolome: metabolism of chiral and non-chiral polychlorinated biphenyls to chiral hydroxylated metabolites in humans and rats." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6657.

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Polychlorinated biphenyls (PCBs) continue to pose a health concern because of their predominance in the diet and air as well as in environmental samples and humans. PCB congeners with 3 or 4 chlorine substituents in ortho position have been associated with neurodevelopmental disorders. Hydroxylated metabolites (OH-PCBs) of these PCBs are also potentially toxic to the developing brain. Metabolism studies have mainly focused on animal models. However, preliminary data from this dissertation work have revealed PCB metabolism differences between laboratory animal models and humans in terms of meta

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Cardoso, Juciane Lauren Cavalcanti. "Influência da exposição inalatória a combustíveis automotivos na atividade do CYP3A, CPY2C e CYP2D em ratos tratados com fármacos quirais." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-10012013-155615/.

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A maioria dos agentes terapêuticos, frequentemente prescritos são formulados e comercializados sob a forma racêmica, embora para alguns deles, já tenha sido demonstrado que os efeitos farmacológicos e ou tóxicos estejam relacionados apenas a um dos enantiômeros. Além disso, é conhecido o fato de que os enantiômeros podem apresentar perfis farmacocinéticos e farmacodinâmicos diferentes. O estudo avaliou a influência da exposição inalatória ao vapor de gasolina e ao etanol combustível na farmacocinética enantiosseletiva dos fármacos verapamil, ibuprofeno e fluoxetina. Ratos machos Wistar foram d

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Zackrisson, Anna-Lena. "Pharmacogenetics from a Forensic Perspective : CYP2D6 and CYP2C19 genotype distributions in autopsy cases." Doctoral thesis, Linköpings universitet, Klinisk farmakologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17936.

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In Sweden about 550 individuals die every year due to drug intoxication. A challenge for the forensic toxicologist is to determine whether or not the analytical results can explain intoxication as a cause of death. The most common drugs found among intoxication cases are psychiatric drugs and analgesics. Many of these drugs are metabolised by CYP-enzymes such as CYP2D6 and CYP2C19. Genetic variations, polymorphisms, in the genes coding for these enzymes can lead to an inactive enzyme resulting in poor metabolism, which can lead to adverse drug reactions, even with fatal outcome. The CYP2D6 gen

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Books on the topic "CYP2CP"

1

Nowak, Maciej P. Comparison of polymorphic CYP2D6, CYP2C19 and CYP2A6 in Canadian Native Indian, Caucasian and Chinese populations. National Library of Canada = Bibliothèque nationale du Canada, 1999.

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Goodz, Shari D. Investigating aspects of CYP2A6 in Caucasian and African American smokers. National Library of Canada, 2002.

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Zeman, Marilyn Vera. evaluation of coumarin as an in vivo measure of CYP2A6 activity. National Library of Canada, 1998.

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Pianezza, Michael Lawrence. The influence of genetically variable CYP246 on tobacco dependence and smoking behaviour. National Library of Canada, 1998.

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Ramamoorthy, Yamini. In vitro characterization of the catalytic activity of cytochrome P450 2D6 (CYP2D6)*10. National Library of Canada, 2000.

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Pelkonen, Päivi. Involvement of Hamster CYP2A enzymes in the bioactivation of chemical carcinogens. University of Kuopio, 1995.

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Dortok, E. Desiree. Analysis of the possible therapeutic use of CYP2A6 inhibition with methoxsalen in smoking cessation. National Library of Canada, 2001.

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Micu, Alina L. An investigation of the induction of hepatic CYP2E1 by low doses of nicotine in the rat. National Library of Canada, 2003.

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Berns, Trevor Aaron. The influence of CYP2D1 in the behavioural pharmacology of amphetamine and hydrocodone in the male wistar rat. National Library of Canada, 1995.

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Lekas, Poli. Analysis of human CYP2E1 mRNA in a HepG2 cell line by reverse transcription-polymerase chain reaction (RT-PCR). National Library of Canada, 1998.

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Book chapters on the topic "CYP2CP"

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Zhang, Qing-Yu, and Xinxin Ding. "Chapter 10. The CYP2F, CYP2G and CYP2J Subfamilies." In Issues in Toxicology. Royal Society of Chemistry, 2008. http://dx.doi.org/10.1039/9781847558428-00309.

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Fergerson, Byron Douglas, Crystal B. Wallentine, and Randal O. Dull. "CYP2C9: The Support Crew I." In A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-7495-1_10.

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Ferguson, Stephen S., Karen Black, and Jonathan P. Jackson. "Chapter 7. The CYP2C Subfamily." In Issues in Toxicology. Royal Society of Chemistry, 2008. http://dx.doi.org/10.1039/9781847558428-00200.

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Gmelch, Benjamin S., and Randal O. Dull. "CYP2E1: The Anesthesia Enzyme." In A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-7495-1_6.

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Jericho, Barbara, Alfredo Aguiar, and Randal O. Dull. "CYP2C19: The Support Crew II." In A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-7495-1_11.

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Sanders, John C., Rachel Koll, and Randal O. Dull. "CYP2D6: Where It All Began." In A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-7495-1_5.

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Coyle, Dustin, and Randal O. Dull. "CYP2B: 2B or Not 2B?" In A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-7495-1_9.

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Raunio, Hannu, Jukka Hakkola, and Olavi Pelkonen. "Chapter 5. The CYP2A Subfamily." In Issues in Toxicology. Royal Society of Chemistry, 2008. http://dx.doi.org/10.1039/9781847558428-00150.

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Corcos, Laurent, and François Berthou. "Chapter 6. The CYP2B Subfamily." In Issues in Toxicology. Royal Society of Chemistry, 2008. http://dx.doi.org/10.1039/9781847558428-00178.

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Zanger, Ulrich M. "Chapter 8. The CYP2D Subfamily." In Issues in Toxicology. Royal Society of Chemistry, 2008. http://dx.doi.org/10.1039/9781847558428-00241.

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Conference papers on the topic "CYP2CP"

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Wang, Xiaodong, Zhi-Yi Zhang, Jing Wang, et al. "Abstract C62: Effects of rolapitant on the pharmacokinetics of dextromethorphan (CYP2D6), tolbutamide (CYP2C9), omeprazole (CYP2C19), efavirenz (CYP2B6), and repaglinide (CYP2C8) in healthy subjects." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-c62.

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Ciorsac, Alecu, Diana Larisa Vlădoiu, Charline Fagnen, Maxime Louet, Maria A. Miteva, and Adriana Isvoran. "Assessment of some pesticides interactions with human cytochrome P450: CYP2C8, CYP2C9 and CYP2C19 by molecular docking approach." In 9TH INTERNATIONAL PHYSICS CONFERENCE OF THE BALKAN PHYSICAL UNION (BPU-9). AIP Publishing LLC, 2016. http://dx.doi.org/10.1063/1.4944305.

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Molden, E. "Identifying CYP2C19 and CYP2D6 poor metabolizers from TDM data." In XVth Symposium of the Task Force Therapeutic Drug Monitoring of the AGNP. Georg Thieme Verlag, 2024. http://dx.doi.org/10.1055/s-0044-1779557.

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Zhang, Gufen. "Frequencies of Clinically Important CYP2C19 and CYP2D6 Alleles across East Asian populations." In ICBBS 2021: 2021 10th International Conference on Bioinformatics and Biomedical Science. ACM, 2021. http://dx.doi.org/10.1145/3498731.3498740.

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Costa, José Cássio Figueira. "PREDIÇÃO DAS PROPRIEDADES FÍSICO-QUÍMICAS E FARMACOCINÉTICAS DO 7-HIDROXI-5-ACETOXIBISABOLENO: NOVA MOLÉCULA CONGÊNERE DO ALFA-BISABOLOL IDENTIFICADO EM LYCHNOPHORA ERICOIDES MART." In II Congresso Brasileiro de Biotecnologia On-line. Revista Multidisciplinar de Educação e Meio Ambiente, 2022. http://dx.doi.org/10.51189/conbiotec/49.

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Introdução: O metabolismo secundário vegetal é uma das principais responsáveis pela produção de uma grande diversidade de moléculas com potencial bioativo. A elucidação e caracterização molecular de novos compostos bioativos geram bases para estudos químicos e biológicos visando à produção e desenvolvimento de novos fármacos. A quimioinformática torna viável, a partir de algoritmos, a caracterização molecular de substâncias com estruturas elucidadas. O 7-hidroxi-5-acetoxibisaboleno (BoAcet) é um análogo terpenoídico do alfa-bisabolol, possui um agrupamento acetóxi ligado a um carbono secundári

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Borchert, AntonW, HannahB Maier, Rasmus Schülke, et al. "CYP2C19 and CYP2D6 genotyping in a cohort of patients with treatment-resistant depression." In Abstracts of the 3rd Symposium of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) and Deutsche Gesellschaft für Biologische Psychiatrie (DGBP). Georg Thieme Verlag, 2022. http://dx.doi.org/10.1055/s-0042-1757668.

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Han, Weiguo, Weizhu Yang, Xueshu li, et al. "Effects of 3,3’-Dichlorobiphenyl (PCB-11) on the expression of CYP2A, 2B, and 2F enzymes in the liver and brain of CYP2A6-humanized, CYP2B6-humanized, or wild-type mice." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.283890.

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Evans, William, Jazmine Eccles, and William Baldwin. "Changes in Energy Metabolism Induced by PFOS and Dietary Oxylipins." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/jnpe5541.

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CYP2B6 is a drug metabolizing cytochrome P450 (CYP) that has anti-obesity properties, but also increases non-alcoholic fatty liver disease (NAFLD) in hCYP2B6-transgenic mice compared to Cyp2b-null mice. hCYP2B6-transgenic mice are also more susceptible to perfluorooctane sulfonic acid (PFOS) toxicity, a lipid-like toxicant used in stains, varnishes and firefighting foams that increase NAFLD. Our recent research demonstrates that CYP2B6 metabolizes dietary polyunsaturated fatty acids into the oxylipins, 9-HODE and 9-HOTre, which are strong peroxisome proliferator activated receptor alpha (PPARa

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Лифшиц, Г., G. Lifshic, Е. Зеленкская, et al. "Association of polymorphisms Gene CYP2C19 with endpoints of efficacy and safety of clopidogrel therapy And platelet aggregation in patients with acutecoronary syndrome study Protocol." In Topical issues of translational medicine: a collection of articles dedicated to the 5th anniversary of the day The creation of a department for biomedical research and technology of the Irkutsk Scientific Center Siberian Branch of RAS. INFRA-M Academic Publishing LLC., 2017. http://dx.doi.org/10.12737/conferencearticle_58be81ec9680e.

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Aim: to reveal the association of gene CYP2C19 polymorphisms and efficacy and safety endpoints of clopidogrel therapy in patients with acute coronary syndrome. Materials and methods. A total of 431 patients with acute coronary syndrome undergoing coronary stent placement was studied. CYP2C19 polymorphisms (*2, *3, *17) were evaluated, platelet aggregation with ADP and efficacy and safety for 30 days after coronary stent placement was studied. Results. Within the selected patients there was no significant association between carriage of at least one allele of the CYP2C19*2, and/or CYP2C19*3 and

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Leong, Chee-Onn, Boon Shing Tan, Kai Hung Tiong, et al. "Abstract C75: CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW610, NSC 721648) sensitivity in breast and colorectal cancer cells." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-c75.

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Reports on the topic "CYP2CP"

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กิจสนาโยธิน, พรพิมล. การศึกษาความสัมพันธ์ระหว่างความหลากหลายทางพันธุกรรมในยีน CYP2C9, CYP2C19 และ ABCB1 ร่วมกับความผันแปรที่ไม่ใช่พันธุกรรมกับขนาดยาเฟนิทอยน์ในผู้ป่วยโรคลมชักชาวไทย : รายงานวิจัย. คณะเภสัชศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2014. https://doi.org/10.58837/chula.res.2014.23.

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ลาวัณย์ประเสริฐ, สมทรง, พรพิมล กิจสนาโยธิน, นวลศรี นิวัติศัยวงศ์, มยุรี ตันติสิระ та ชำนาญ ภัตรพานิช. ผลของวัลโปรอิล มอร์โฟลีนต่อเอนไซม์ไซโตโครมพี 450 ในตับหนูขาว. จุฬาลงกรณ์มหาวิทยาลัย, 2001. https://doi.org/10.58837/chula.res.2001.28.

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ศึกษาผลของวัลโปรอิล มอร์โฟลีน (วีพีเอ็ม) ต่อเอนไซม์ไซโตโครม พี 450 ในตับหนูขาว โดยการฉีดวีพีเอ็ม และวัลโปรอิค แอซิค (วีพีเอ) ซึ่งเป็นสารต้นแบบของวีพีเอ็มในขนาดที่ต้านชักได้ในสัตว์ทดลองจำนวนครึ่งหนึ่ง (100 มิลลิกรัม/กิโลกรัม/วัน สำหรับวีพีเอ็ม และ 250 มิลลิกรัม/กิโลกรัม/วัน สำหรับวีพีเอ) และวีพีเอ็ม ขนาด 200 มิลลิกรัม/กิโลกรัม/วัน แก่หนูขาวเพศผู้ทางหน้าท้อง เป็นเวลา 7 วัน หลังจากนั้นฆ่าหนู แล้วเตรียมไมโครโวมจากตับ ทำการวิเคราะห์หาปริมาณไวโตโครม พี 450 รวม และแอคติวิตีของไซโตโครม พี 450 จากไมโครโซม ผลการวิจัยพบว่า ทั้งวีพีเอ็มและวีพีเอไม่มีผลเปลี่ยนแปลงค่าต่าง ๆ เหล่านี้ : ปริมาณไซโตโครม พี 450

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Lawanprasert, Somsong, Chaiyo Chaichantipyuth, Supatra Srichairat, Nuansri Niwattisaiwong, and Laddawal Phivthong-ngam. Subchronic exposure of Pueraria mirifica in normal - and high cholesterol diet fed rats : influence on hepatic cytochrome P450, lipid profile and toxicity. Chulalongkorn University, 2004. https://doi.org/10.58837/chula.res.2004.28.

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Pueraria mirifica airy shaw and suvatabandhu, know locally as Kwao Keur, is a plant in family Leguminosae. In this study, effects of P.mirifica on hepatic cytochrome P450 (CYP), serum lipid profile and subchronic toxicity were investigated in male Wistar rats. Rats were randomly divided into four treatment groups as following: normal diet-fed group; normal diet-fed supplemented with P.mirifica group; high cholesterol diet-fed group; high cholesterol diet-fed supplemented with P.mirifica group. Each group comprised 10 rats. P.mirifica was administered orally at a dosage of 100 mg/kg/day for 90

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Dudley, A., M. M. Peden-Adams, J. E. Daly, and D. E. Keil. JP-8 Jet Fuel Induces CYP2B1, CYP2BE1, and GSTPI but not CYP1A1 in Murine Liver. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada402064.

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Lamb, Dolores J. Enhancement of Vitamin D Action in Prostate Cancer through Silencing of CYP24. Defense Technical Information Center, 2009. http://dx.doi.org/10.21236/ada502323.

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Lamb, Dolores. Enhancement of Vitamin D Action in Prostate Cancer through Silencing of CYP24. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada550337.

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Lamb, Dolores J. Enhancement of Vitamin D Action in Prostate Cancer through Silencing of CYP24. Defense Technical Information Center, 2010. http://dx.doi.org/10.21236/ada625333.

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Lamb, Dolores J. Enhancement of Vitamin D Action in Prostate Cancer through Silencing of CYP24. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada482357.

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Casabar, Richard C., Andrew D. Wallace, Ernest Hodgson, and Randy L. Rose. Metabolism of Endosulfan-Alpha by Human Liver Microsomes and its Utility as a Simultaneous In Vitro Probe for CYP2B6 and CYP3A4. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada445178.

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Cargnin, Sarah, Federica Ferrari, and Salvatore Terrazzino. Impact of CYP2C19 genotype on clinical outcomes of non-Asian patients with stroke or transient ischemic attack undergoing clopidogrel therapy: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.7.0067.

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