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Dissertations / Theses on the topic 'CYP2CP'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Wang, Haoyi. "ORGANIZATION AND EVOLUTION OF THE CYP2A-T GENE SUBFAMILY CLUSTER IN RODENTS, AND A COMPARISON TO THE SYNTENIC HUMAN CLUSTER." Miami University / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=miami1050615100.

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2

Wang, Jue. "Regulation and polymorphism of CYP2A6, CYP2B6 and CYP2E1 : functional and clinical aspects /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-650-6/.

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3

Nowak, Maciej P. "Comparison of polymorphic CYP2D6, CYP2C19 and CYP2A6 in Canadian Native Indian, Caucasian and Chinese populations." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29327.pdf.

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4

Prado, Carolina Martins do. "Desenvolvimento de metodologia para a determinação dos genótipos principais dos genes CYP2D6, CYP2C19 e CYP2C9: aplicação na farmacogenética." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-30042010-093536/.

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As enzimas CYP2D6, CYP2C19 e CYP2C9 são responsáveis pelo metabolismo de aproximadamente metade dos 200 medicamentos mais prescritos nos EUA. Padronizamos ensaios de genotipagem baseados na discriminação alélica com o sistema TaqMan® em 198 indivíduos. Para o gene CYP2D6, os alelos *1 e *2 foram os mais freqüentes, seguidos pelos alelos *4, *41, *35, *17, *5, *10, *6, *29 e *9. Desenvolvemos também uma nova metodologia para a determinação do número de cópias do gene CYP2D6. Para o gene CYP2C19, o alelo *1 foi o mais frequente, seguido pelos alelos *17, *2 e *3. Nosso estudo foi o primeiro a de

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5

Müller, Gunnar. "Bedeutung der genetischen Polymorphismen in den Enzymen CYP2D6, CYP2C19 und CYP2C9 für Pharmakokinetik der trizyklischen Antidepressiva Doxepin und Trimipramin." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15377.

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Mehrere Studien wiesen eine Beteiligung der Enzyme CYP2D6, CYP2C19 und CYP2C9 am Metabolismus von trizyklischen Antidepressiva nach. Wir untersuchten die Auswirkungen genetischer Polymorphismen dieser Enzyme auf die Pharmakokinetik von E-, Z-Doxepin und Trimipramin beim Menschen. Eine einzelne orale Dosis von jeweils 75 mg Trimipramin und Doxepin wurde 42 gesunden Probanden verabreicht, die als Schnell- (EM), Intermediär- (IM) und Langsammetabolisierer (PM) von CYP2D6- und CYP2C19-Substraten und als Langsammetabolisierer mit dem CYP2C9-Genotyp *3/*3 genotypisiert worden waren. Die Substrate so

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6

Gültepe, Şenol [Verfasser], Jürgen [Akademischer Betreuer] Brockmöller, Patricia [Akademischer Betreuer] Virsik-köpp, and Dirk [Akademischer Betreuer] Vollmann. "Auswirkungen von CYP2D6-, CYP2C9- und CYP2C19-Polymorphismen auf Pharmakokinetik und Wirkungen von Carvedilol / Şenol Gültepe. Gutachter: Patricia Virsik-Köpp ; Dirk Vollmann. Betreuer: Jürgen Brockmöller." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2011. http://d-nb.info/1044045728/34.

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7

Lorberg, Caroline. "Bedeutung von Cytochrom-P450-Polymorphismen für Verlauf, Erfolg und Nebenwirkungen der Therapie mit Antidepressiva." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15375.

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Im Bereich der medikamentösen antidepressiven Therapie ist die Bedeutung von erblichen Polymorphismen arzneistoffmetabolisierender Enzyme bereits in vielen Studien untersucht und gezeigt worden. Die meisten Antidepressiva werden über polymorphe Cytochrom-P450-Enzyme verstoffwechselt. Diese Arbeit befasst sich mit der Fragestellung, ob die Häufigkeitsverteilung der CYP2D6-, CYP2C19- und CYP2C9-Allele in der an Depression erkrankten Studienpopulation sich von der in der Normalbevölkerung unterscheidet und ob Veränderungen in der Pharmakokinetik, wie sie durch Cytochrom-P450-Polymorphismen verurs

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8

Uwimana, Eric. "Probing the PCB metabolome: metabolism of chiral and non-chiral polychlorinated biphenyls to chiral hydroxylated metabolites in humans and rats." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6657.

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Polychlorinated biphenyls (PCBs) continue to pose a health concern because of their predominance in the diet and air as well as in environmental samples and humans. PCB congeners with 3 or 4 chlorine substituents in ortho position have been associated with neurodevelopmental disorders. Hydroxylated metabolites (OH-PCBs) of these PCBs are also potentially toxic to the developing brain. Metabolism studies have mainly focused on animal models. However, preliminary data from this dissertation work have revealed PCB metabolism differences between laboratory animal models and humans in terms of meta

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9

Cardoso, Juciane Lauren Cavalcanti. "Influência da exposição inalatória a combustíveis automotivos na atividade do CYP3A, CPY2C e CYP2D em ratos tratados com fármacos quirais." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-10012013-155615/.

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A maioria dos agentes terapêuticos, frequentemente prescritos são formulados e comercializados sob a forma racêmica, embora para alguns deles, já tenha sido demonstrado que os efeitos farmacológicos e ou tóxicos estejam relacionados apenas a um dos enantiômeros. Além disso, é conhecido o fato de que os enantiômeros podem apresentar perfis farmacocinéticos e farmacodinâmicos diferentes. O estudo avaliou a influência da exposição inalatória ao vapor de gasolina e ao etanol combustível na farmacocinética enantiosseletiva dos fármacos verapamil, ibuprofeno e fluoxetina. Ratos machos Wistar foram d

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10

Zackrisson, Anna-Lena. "Pharmacogenetics from a Forensic Perspective : CYP2D6 and CYP2C19 genotype distributions in autopsy cases." Doctoral thesis, Linköpings universitet, Klinisk farmakologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17936.

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In Sweden about 550 individuals die every year due to drug intoxication. A challenge for the forensic toxicologist is to determine whether or not the analytical results can explain intoxication as a cause of death. The most common drugs found among intoxication cases are psychiatric drugs and analgesics. Many of these drugs are metabolised by CYP-enzymes such as CYP2D6 and CYP2C19. Genetic variations, polymorphisms, in the genes coding for these enzymes can lead to an inactive enzyme resulting in poor metabolism, which can lead to adverse drug reactions, even with fatal outcome. The CYP2D6 gen

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11

Almeida, Adriana Ávila de. "Expressão dos genes CYP1A1, CYP1B1, CYP2A6 e CYP2E1 em fumantes com câncer bucal. /." São José dos Campos, 2018. http://hdl.handle.net/11449/153357.

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Orientador: Janete Dias Almeida<br>Coorientador: Celina Faig Lima Carta<br>Banca: Emília Ângela Lo Schiavo Arisawa<br>Banca: Ana Lia Anbinder<br>Banca: Alberto José de Araújo<br>Banca: José Benedito Oliveira Amorim<br>Resumo: Os carcinógenos do tabaco estão relacionados a diversos tipos de câncer incluindo o carcinoma de células escamosas (CCE) bucal. Aliado ao álcool, o tabaco contribui para o desfecho desfavorável destes casos. A susceptibilidade individual ao câncer pode estar relacionada a expressão das enzimas que metabolizam tais carcinógenos. O objetivo deste trabalho é avaliar a expres

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12

Almeida, Adriana Ávila de [UNESP]. "Expressão dos genes CYP1A1, CYP1B1, CYP2A6 e CYP2E1 em fumantes com câncer bucal." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153357.

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Submitted by Adriana Ávila de Almeida null (celdrica2003@yahoo.com.br) on 2018-03-23T16:45:45Z No. of bitstreams: 1 Tese Final - Adriana Ávila de Almeida.pdf: 2506211 bytes, checksum: e38a3f026d55d541be0fd2ec9142a2a2 (MD5)<br>Approved for entry into archive by Silvana Alvarez null (silvana@ict.unesp.br) on 2018-04-03T21:06:34Z (GMT) No. of bitstreams: 1 almeida_aa_dr.sjc.pdf: 2506211 bytes, checksum: e38a3f026d55d541be0fd2ec9142a2a2 (MD5)<br>Made available in DSpace on 2018-04-03T21:06:34Z (GMT). No. of bitstreams: 1 almeida_aa_dr.sjc.pdf: 2506211 bytes, checksum: e38a3f026d55d541be0fd2ec9

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13

Coller, Janet K. "The Influence of the CYP2C19 and CYP2D6 genetic polymorphisms on oxidative drug metabolism." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phc6968.pdf.

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Amendements: leaves 252-254. Copies of author's previously published articles inserted. Bibliography: leaves 226-251. The CYP2C19 and CYP2D6 genetic polymorphisms control the oxidative metabolism of many different drug classes. Populations are separated into groups of extensive metabolisers (EM), poor metabolisers (PM), and in the case of CYP2D6, ultra-rapid metabolisers (UM). In vitro studies using human liver microsomes were conducted to examine the kinetics of the oxidative metabolism of flunitrazepam, and which CYP450 enzymes mediate the oxidative metabolism of flunitrazepam, (S)-mephenyto

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14

Thörn, Helena Anna. "First-pass Intestinal Metabolism of Drugs : Experiences from in vitro, in vivo and simulation studies." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-165514.

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The bioavailability of a drug can be described as the fraction of an orally administered dose that reaches the systemic circulation and is often limited by first-pass metabolism in the gut and the liver. It is important to have knowledge about these processes since the systemic blood drug concentration is tightly connected to the effect of the drug. The general aim of this project was to quantitatively examine the role of the intestine in relation to the liver in first-pass metabolism of orally administered drugs. The first-pass metabolism of verapamil and raloxifene was investigated in detail

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15

Nail, Alexandra Nichole. "EVOLUTION OF THE ZHX TRANSCRIPTION FACTOR FAMILY AND ANALYSIS OF ZHX2 TARGET GENES CYP2A4 AND CYP2A5 IN MOUSE LIVER." UKnowledge, 2019. https://uknowledge.uky.edu/microbio_etds/20.

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The liver is the largest internal organ and performs a wide variety of functions to maintain organismal homeostasis. While some liver functions are carried out by all hepatocytes, other functions are restricted to certain populations of hepatocytes within the liver. This phenomenon, called zonal gene regulation or liver zonation, controls may metabolic processes within the liver including ammonia detoxification; glucose homeostasis; bile acid and glutamine synthesis; and metabolism of xenobiotics, lipids, and amino acids. The liver also expresses many genes in a developmental or sex-biased man

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16

Sommer, Karen Marie. "Identification and characterization of elements regulating the expression of the phenobarbital-inducible CYP2B1 and CYP2B2 genes /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/8477.

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17

Hofmann, Marco Hans. "Microarray and molecular genetic analysis of aberrant splicing in human drug metabolizing cytochromes P450 CYP2D6 and CYP2B6." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-36010.

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18

Roh, Hyung-Keun. "Drug metabolic capacity in Koreans : CYP2D6 & CYP2C19 pheno- and genotype relationships in healthy volunteers and in patients /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-169-1.

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19

Janha, Ramatoulie. "Effects of inactive CYP2C19/Cyp2C9 alleles on chlorproguanil pharmacokinetics in adults and treatment outcome in children with uncomplicated malaria following lapdap (R) treatment." Thesis, Open University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533125.

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20

Boronat, Rigol Anna 1990. "Tyrosol and its endogenous conversion into hydroxytyrosol in humans : Dietary sources, genetic modulation and clinical effects." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/668336.

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Hydroxytyrosol is a health-promoting dietary phenol mainly present in extra virgin olive oil. Wine and beer are sources of tyrosol, a related phenolic compound. We have demonstrated that in humans tyrosol is endogenously converted into hydroxytyrosol following wine and beer consumption. Therefore, tyrosol rich foods could trigger equivalent health effects than those of hydroxytyrosol ones. The conversion of tyrosol into hydroxytyrosol is mediated by the polymorphic cytochrome P450 isoenzymes CYP2A6 and CYP2D6. In a randomized controlled clinical trial, we have shown that tyrosol and its conver

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21

Aitchison, Katherine Jean. "Pharmacogenetic studies of CYP2D6, CYP2C19 and CYP1A2, and investigation of their role in clinical response to antipsychotics and antidepressants." Thesis, King's College London (University of London), 2003. https://kclpure.kcl.ac.uk/portal/en/theses/pharmacogenetic-studies-of-cyp2d6-cyp2c19-and-cyp1a2-and-investigation-of-their-role-in-clinical-response-to-antipsychotics-and-antidepressants(fbe2703f-8442-48c5-af21-57c4a778e0da).html.

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22

Hutzler, James Matthew. "Factors affecting CYP2C9-mediated metabolism." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2204.

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Thesis (Ph. D.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains viii, 199 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 176-195).

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23

Beck, Nancy Beth. "Phenobarbital mediated induction of the cytochrome P450 2B genes : mechanistic investigations /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/8449.

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24

Deng, Yifu. "Case-only study of interactions between specific genetic polymorphisms and cigarette smoking in the aetiology of Parkinson's disease." Queensland University of Technology, 2005. http://eprints.qut.edu.au/16211/.

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The aetiology of Parkinson's disease (PD) is still unclear. Research findings suggest that both environmental and genetic factors may contribute to its development. The interactions between genes and the environment might exist and play a key role. Cigarette smoking was found to be one of the few factors exhibiting a protective effect. If chemical compounds found in cigarette smoke influence PD risk, the difference in the ability of certain individuals in metabolising these substances might alter their susceptibility to the risk of developing PD. Many metabolic enzyme genes exhibit polymorphic

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25

Hummel, Matthew Aaron. "Dapsone activation of CYP2C9 allelic variants." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2767.

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Thesis (M.S.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains vi, 42 p. : ill. Includes abstract. Includes bibliographical references (p. 35-42).

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26

Rodríguez-Morató, Jose 1987. "Metabolism of natural antioxidants: evaluation of the pathways involved in the in vivo biotransformation of tyrosol into hydroxytyrosol." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/386541.

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Hydroxytyrosol [2-(3,4-dihydroxyphenyl)ethanol], a potent bioactive molecule mainly present in virgin olive oil and to a lower extent in wine, is also a by-product of dopamine metabolism. In a previous clinical trial designed to assess the effects of moderate wine intake it was found that hydroxytyrosol urinary recoveries were higher than the corresponding to the dose administered, suggesting an endogenous formation. The aim of the present work was to assess new mechanisms responsible for hydroxytyrosol generation by using an array of methodologies and studies ranging from in vitro assays to i

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27

Franken, Cora Christina [Verfasser], Andreas [Akademischer Betreuer] Mügge, and Thomas [Akademischer Betreuer] Deneke. "Vollblutaggregometrische Untersuchungen zur Thrombozytenfunktionshemmung von Prasugrel verglichen mit Clopidogrel und Korrelation von Prasugrel Low-Respondern mit CYP2B6 und CYP2C9 Polymorphismen / Cora Christina Franken. Gutachter: Andreas Mügge ; Thomas Deneke." Bochum : Ruhr-Universität Bochum, 2015. http://d-nb.info/1079843183/34.

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28

Aatsinki, S. M. (Sanna-Mari). "Regulation of hepatic glucose homeostasis and Cytochrome P450 enzymes by energy-sensing coactivator PGC-1α". Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526208053.

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Abstract Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a master regulator of energy metabolism and mitochondrial biology in high-energy cell types and tissues. The regulation of PGC-1α is versatile, and both transcriptional and post-transcriptional mechanisms play major roles. External stimuli affect PGC-1α-regulation which in turn adapts cellular signals to meet them. For example, conditions like fasting and diabetes mellitus (DM) are known to activate PGC-1α expression in the liver, resulting in enhanced de novo glucose production, gluconeogenesis. In the present st

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29

Panserat, Stéphane. "Polymorphisme genetique du locus cyp2d du p450 debrisoquine 4-hydroxylase (cyp2d6) chez l'homme : bases moleculaires de l'heterogeneite du groupe des metaboliseurs rapides." Paris 7, 1995. http://www.theses.fr/1995PA077242.

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Le polymorphisme genetique du cyp2d6 humain se manifeste par un profil bimodal de distribution des rapports metaboliques (mr) (substrat/metabolite(s)), definissant des individus metaboliseurs rapides (em) et metaboliseurs lents (pm). Le phenotype pm se caracterise par une absence totale d'activite cyp2d6 au niveau hepatique. Le locus cyp2d est compose de trois genes homologues (cyp2d6, cyp2d7 et cyp2d8p), mais seul le gene cyp2d6 est fonctionnel. Notre objectif a ete d'etablir une correlation precise entre le genotype cyp2d et l'expression de cyp2d6 dans une population de sujets sains. Nous av

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30

Afzelius, Lovisa. "Computational Modelling of Structures and Ligands of CYP2C9." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4016.

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31

Aoyama, Ronald Gordon. "Probing the active site of cytochrome P450 CYP2C9 /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8188.

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32

Matthaei, Johannes [Verfasser], Jürgen [Akademischer Betreuer] Brockmöller, Heike [Akademischer Betreuer] Bickeböller, and Margarete [Akademischer Betreuer] Schön. "Erblichkeit in der Aktivität der Enzyme CYP2D6 und CYP2C9 sowie des Transporters OATP1B1 unter Berücksichtigung der bereits bekannten genetischen Varianten / Johannes Matthaei. Gutachter: Heike Bickeböller ; Margarete Schön. Betreuer: Jürgen Brockmöller." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/1056804548/34.

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33

Salamat, Julia. "The Role of CYP2A5 in Cadmium-Induced Liver Injury." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etd/3498.

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Cadmium is present in food and groundwater. Tobacco smoking and occupational exposure are also major sources for cadmium. Cadmium is primarily accumulated in liver, a major organ metabolizing exogenous chemicals. Chemical metabolism may cause detoxification, but it can also cause bio-activation resulting in liver damage. Cytochrome P450s (CYP) are major liver metabolism enzymes, and cadmium chloride (CdCl2) can induce CYP2A5 in mice. We examined the effect of CYP2A5 on CdCl2-induced liver injury using CYP2A5-knockout (cyp2a5-/-) mice. The cyp2a5-/- mice and their control WT mice were injected

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34

Deng, Yifu. "Case-only study of interactions between specific genetic polymorphisms and cigarette smoking in the aetiology of Parkinson's disease." Thesis, Queensland University of Technology, 2005. https://eprints.qut.edu.au/16211/1/Yifu_Deng_Thesis.pdf.

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The aetiology of Parkinson's disease (PD) is still unclear. Research findings suggest that both environmental and genetic factors may contribute to its development. The interactions between genes and the environment might exist and play a key role. Cigarette smoking was found to be one of the few factors exhibiting a protective effect. If chemical compounds found in cigarette smoke influence PD risk, the difference in the ability of certain individuals in metabolising these substances might alter their susceptibility to the risk of developing PD. Many metabolic enzyme genes exhibit polymorphic

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35

Morin, Sandrine. "La pharmacogénétique du type CYP2C9 et des anticoagulants oraux." Paris 5, 2003. http://www.theses.fr/2003PA05P607.

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Le cytochrome P450 2C9 (CYP2C9) métabolise 20% des médicaments et est impliqué dans le métabolisme de molécules à index thérapeutique étroit : warfarine (antagoniste de la vitamine K, AVK), acénocoumarol (AVK). Ce CYP est génétiquement polymorphique. Deux allèles CYP2C9*2 et CYP2C9*3 affectent la posologie de la warfarine. Les patients ayant un de ces allèles (métaboliseurs lents, ML) ont des posologies d'AVK (warfarine, acénocoumarol) significativement plus faibles que les patients sans ces mutations. Il n'y a aucun test de phénotypage pour détecter les ML. Nous avons essayé de mettre au poin

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36

Arslan, Sevki. "Effects Of Benzene On Liver, Kidney And Lung Cyp1a, Cyp2b4, Cyp2e1 And Cyp3a6 Mrna, Protein Level, And Drug Metabolizing Enzyme Activities And Toxicity In Diabetic Rabbits." Phd thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609446/index.pdf.

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The effects of diabetes on cytochrome P450 dependent drug metabolizing enzymes have not to be clarified yet. The most widely used animals in these studies have been rats, and information regarding the effects of diabetes on cytochrome P450 dependent procarcinogen/carcinogen metabolism in rabbits is limited. In the present study, we investigated, for the first time, the influence of benzene on liver, kidney and lung microsomal cytochrome P450 dependent drug metabolizing enzyme activities, protein and mRNA levels in diabetic and non-diabetic rabbits. Male New Zealand rabbits were made diabetic

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37

Christian, Kyle. "The role of hnRNP A1 and hnRNP C1/C2 in the regulation of the stress responsive genes Cyp2a5/2A6 and p53." Doctoral thesis, Uppsala University, Department of Pharmaceutical Biosciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8722.

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<p>The family of proteins known as heterogeneous nuclear ribonucleoproteins (hnRNPs) is large and diverse. Often, one and the same hnRNP will perform multiple cellular functions, leading to their description as “multifunctional proteins”. The two hnRNPs known as hnRNP A1 and hnRNP C1/C2 are multifunctional proteins found to affect the transcription, splicing, stability, and translation of specific genes’ mRNA. They are implicated in carcinogenesis, apoptosis, and DNA damage response mechanisms.</p><p>The aims of this thesis were to study the hnRNP A1 and hnRNP C1/C2 dependent regulation of two

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38

Devereux, R. Mark. "Substrate / inhibitor influence on CYP2C8 with implications for related isoforms." Thesis, University of Aberdeen, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425103.

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Compounds were hydroxylated in incubations containing CYP1A2, CYP2B6, or CYP2C19 Supersomes<sup>TM</sup>, with a large turnover number observed for CYP2B6-dependent flavonone metabolism (>20% loss of parent). These analogues did not appear to be within a critical distance of the haem moiety in CYP2C8 or CYP3A4 substrate-binding sites as evidenced by lack of metabolism. The paclitaxel precursor, baccatin III was also demonstrated not to be a CYP2C8 substrate, with levels of a potentially 6-hydroxylated metabolite being undetectable by LC-MS/MS analyses. Therefore, a C13 paclitaxel side chain

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39

Paquet, Yanick. "Étude fonctionnelle des unités de réponse au phénobarbital des gènes CYP2B1 et CYP2B2 chez le rat et mise au point d'un logiciel de détection de régions régulatrices distales." Thesis, Université Laval, 2007. http://www.theses.ulaval.ca/2007/24406/24406.pdf.

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Davidson, Benjamin Paul. "Studies on the regulation of the barbiturate-inducible cytochrome P450 genes CYP2H1 and CYP2H2 : a thesis submitted for the degree of Doctor of Philosophy at the University of Adelaide." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phd252.pdf.

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Ayscue, Robyn Renee. "Computer modeling of dapsone-mediated heteroactivation of flurbiprofen metabolism by CYP2C9." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5642.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains viii, 174 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 164-174).

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42

Kuon, Jonas [Verfasser]. "Genetisch bedingte Unterschiede der CYP2C9-Aktivität: Einfluss von Enzyminduktion / Jonas Kuon." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2007. http://d-nb.info/1022581384/34.

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43

Horley, Neill. "Molecular basis of CYP2B2 induction." Thesis, University of Nottingham, 1999. http://eprints.nottingham.ac.uk/10397/.

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Many structurally unrelated chemicals can induce members of the cytochrome P450 superfamily with phenobarbital (PB) being a typical example. PB induces CYP2B1/2, which are most highly expressed in the liver. Their mechanism of activation has not yet been elucidated, with advances hampered by the absence of a suitable cell culture system to mimic the in vivo PB-mediated induction. During this thesis a primary rat hepatocyte culture system has been developed which is highly responsive to PB at both RNA and protein levels. A sensitive and specific RNAse protection assay (RPA) has been used to dem

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Ellfolk, Maria. "Regulation of Vitamin D 25-hydroxylases : Effects of Vitamin D Metabolites and Pharmaceutical Compounds on the Bioactivation of Vitamin D." Doctoral thesis, Uppsala universitet, Avdelningen för farmaceutisk biokemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9412.

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A 700bp portion of the promoter of CYP2D25, the porcine microsomal vitamin D 25-hydroxylase was isolated and sequenced. The computer analysis of the sequence revealed the existence of a putative VDRE at 220 bp upstream of the transcription start site. A CYP2D25 promoter-luciferase reporter plasmid was constructed in order to study the transcriptional regulation of the gene. Treatment with the vitamin D metabolites calcidiol and calcitriol suppressed the promoter, provided that the nuclear receptors VDR and RXR were overexpressed. Phenobarbital was also capable of suppressing the promoter if th

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Truong, Nhu Traï. "Etude de la régulation post-transcriptionnelle du CYP2B1 et 2E1 par l'insuline : mise en évidence et localisation d'une interaction ARN-protéines." Paris 5, 2005. http://www.theses.fr/2005PA05S036.

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Il a été montré que le diabète augmentait l'expression des CYP 2E1 et 2B1 de rat au niveau ARN et protéines. Cette élévation a été attribuée à une stabilisation des ARNm et peut être inversé par un traitement quotidien à l'insuline. En utilisant une lignée d'hépatome de rat, il a été précédemment montré au laboratoire que cette hormone agissait par un mécanisme post-transcriptionnel en diminuant la durée de vie des messagers des CYP2E1 et 2B1 de rat. Nous avons entrepris d'identifier les mécanismes moléculaires mis en jeu dans cette régulation. En utilisant des protéines cytoplasmiques provena

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Tai, Guoying. "Structural determinants of CYP2C9's genetic variability, substrate specificity and dioxygen cleavage /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8185.

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Mosher, Carrie M. "CYP2C9 binding determinants and activation mechanisms for phenytoin and (S)-warfarin metabolism /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/8170.

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MEDEIROS, BORBA VIEIRA MARIA ISABEL. "Ontogenese du cyp2e1 hepatique humain : regulation de l'expression du gene cyp2e1 par demethylation des residus cpg." Paris 7, 1997. http://www.theses.fr/1997PA077142.

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Les objectifs de ce travail ont ete l'etude de l'ontogenese du cyp2e1 hepatique humain et la mise en evidence des mecanismes moleculaire impliques dans le controle de l'expression du cyp2e1 au cours du developpement. Le cyp2e1 presente une expression uniquement postnatale : la proteine et les activites enzymatiques correspondantes apparaissent au cours des heures qui suivent la naissance, et augmentent graduellement jusqu'a l'age adulte. Le taux d'arnm cyp2e1 reste faible au cours de la periode perinatale, bien que la concentration de la proteine cyp2e1 augmente immediatement apres la naissanc

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Sundin, Johanna. "Expression and Purification of Full-length CYP26 B1 and Spliced CYP26 B1." Thesis, Örebro University, School of Science and Technology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-7394.

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<p>The goal of this project is to express both the normal CYP26 B1 and the spliced CYP26 B1 from human in <em>Escherichia coli </em>(E.coli) cells for further crystallization. This will be achieved by cloning in the DNA fragments into the Champion pET SUMO vector that is later transformed into <em>E.coli </em>cells. The CYP26 B1 contains a hydrophobic helix at the N-terminal of the protein, making both protein expression and crystallization difficult. Two variants of both full-length CYP26 B1 and the spliced variant will therefore be made, one with the trans-membrane helix present and one with

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Semedo, Agostinho Tavares. "Avaliação da influência dos polimorfismos CYP2C19*2 e CYP2C19*17 na resposta ao tratamento à clozapina na esquizofrenia." Universidade Federal de Goiás, 2017. http://repositorio.bc.ufg.br/tede/handle/tede/6899.

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