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Journal articles on the topic 'Cystathionine-gamma-lyase (CSE)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Roglans, Núria, Elena Fauste, Roger Bentanachs, et al. "Bempedoic Acid Restores Liver H2S Production in a Female Sprague-Dawley Rat Dietary Model of Non-Alcoholic Fatty Liver." International Journal of Molecular Sciences 24, no. 1 (2022): 473. http://dx.doi.org/10.3390/ijms24010473.

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We previously demonstrated that treatment with BemA (bempedoic acid), an inhibitor of ATP citrate lyase, significantly reduces fatty liver in a model of liver steatosis (HFHFr—female Sprague-Dawley rat fed a high-fat high-fructose diet). Since the hepatic production of the gasotransmitter H2S is impaired in liver disorders, we were interested in determining if the production of H2S was altered in our HFHFr model and whether the administration of BemA reversed these changes. We used stored liver samples from a previous study to determine the total and enzymatic H2S production, as well as the ex

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Zhao, Shuang, Céline Deslarzes-Dubuis, Severine Urfer, Martine Lambelet, Sébastien Déglise, and Florent Allagnat. "Cystathionine Gamma Lyase Is Regulated by Flow and Controls Smooth Muscle Migration in Human Saphenous Vein." Antioxidants 12, no. 9 (2023): 1731. http://dx.doi.org/10.3390/antiox12091731.

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The saphenous vein is the conduit of choice for bypass grafting. Unfortunately, the hemodynamic stress associated with the arterial environment of the bypass vein graft leads to the development of intimal hyperplasia (IH), an excessive cellular growth and collagen deposition that results in restenosis and secondary graft occlusion. Hydrogen sulfide (H2S) is a ubiquitous redox-modifying gasotransmitter that inhibits IH. H2S is produced via the reverse trans-sulfuration pathway by three enzymes: cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase

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3

Arroyo Almenas, Francisco, Gábor Törő, Peter Szaniszlo та ін. "Cystathionine Gamma-Lyase Regulates TNF-α-Mediated Injury Response in Human Colonic Epithelial Cells and Colonoids". Antioxidants 13, № 9 (2024): 1067. http://dx.doi.org/10.3390/antiox13091067.

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Cystathionine gamma-lyase (CSE) and TNF-α are now recognized as key regulators of intestinal homeostasis, inflammation, and wound healing. In colonic epithelial cells, both molecules have been shown to influence a variety of biological processes, but the specific interactions between intracellular signaling pathways regulated by CSE and TNF-α are poorly understood. In the present study, we investigated these interactions in normal colonocytes and an organoid model of the healthy human colon using CSE-specific pharmacological inhibitors and siRNA-mediated transient gene silencing in analytical

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Toro, Gabor, Peter Szaniszlo, Francisco Arroyo Almenas, et al. "THE FUNCTION OF THE CYSTATHIONINE-GAMMA-LYASE/HYDROGEN SULFIDE AXIS IN THE PATHOGENESIS OF ULCERATIVE COLITIS." Inflammatory Bowel Diseases 30, Supplement_1 (2024): S62. http://dx.doi.org/10.1093/ibd/izae020.129.

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Abstract INTRODUCTION Current combination therapies in ulcerative colitis (UC) target different inflammatory cascades, including tumor necrosis factor-alpha (TNF-alpha) signaling. However, most patients do not achieve long-term remission, suggesting that the molecular pathophysiology of UC is still poorly understood. Endogenously produced hydrogen sulfide (H2S) has emerged as a critical physiological mediator of gastrointestinal homeostasis, limiting mucosal inflammation and promoting tissue healing in response to epithelial injury. Inhibition of cystathionine-gamma-lyase (CSE)-dependent H2S p

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5

Jamaluddin, Mohammad, Aline Haas de Mello, Nisha Tapryal, Tapas K. Hazra, Roberto P. Garofalo, and Antonella Casola. "NRF2 Regulates Cystathionine Gamma-Lyase Expression and Activity in Primary Airway Epithelial Cells Infected with Respiratory Syncytial Virus." Antioxidants 11, no. 8 (2022): 1582. http://dx.doi.org/10.3390/antiox11081582.

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Cystathionine-y-lyase (CSE) is a critical enzyme for hydrogen sulfide (H2S) biosynthesis and plays a key role in respiratory syncytial virus (RSV) pathogenesis. The transcription factor NRF2 is the master regulator of cytoprotective and antioxidant gene expression, and is degraded during RSV infection. While some evidence supports the role of NRF2 in CSE gene transcription, its role in CSE expression in airway epithelial cells is not known. Here, we show that RSV infection decreased CSE expression and activity in primary small airway epithelial (SAE) cells, while treatment with tert-butylhydro

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Ilieva, Bilyana, Elena Marinova, Hristo Gagov та Rossitza Konakchieva. "Basal and PGF2α-stimulated secretion of pro-inflammatory cytokines from 3T3-L1 adipocyte-like cells". BioDiscovery 20 (1 серпня 2017): e17757. https://doi.org/10.3897/biodiscovery.20.e17757.

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Adipocytes were recently identified as an important source of endocrine and paracrine mediators, regulating the metabolism and activity of various cell types and body functions. 3T3-L1 preadipocytes are useful model for physiological, pharmacological and cell signaling studies. Differentiation of 3T3-L1 murine fibroblasts into adipocyte-like cells was conducted in presence of IBMX, dexamethasone and insulin and demonstrated by Oil Red O staining of accumulated lipid droplets. Using Inflammatory Multi- Analyte Cytokines ELISArray Kit we investigated the release of cytokines under basal conditio

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7

Zhong, Xin, Yuwen Wang, Jichao Wu, et al. "Calcium Sensing Receptor Regulating Smooth Muscle Cells Proliferation Through Initiating Cystathionine-Gamma-Lyase/Hydrogen Sulfide Pathway in Diabetic Rat." Cellular Physiology and Biochemistry 35, no. 4 (2015): 1582–98. http://dx.doi.org/10.1159/000373973.

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Aims: Hydrogen sulfide (H2S) inhibits the proliferation of vascular smooth muscle cells (VSMCs). However, how cystathionine-gamma-lyase (CSE), a major enzyme that produces H2S, is regulated remains unknown. Whether calcium-sensing receptor (CaSR) inhibits the proliferation of VSMCs by regulating the endogenous CSE/H2S pathway in diabetic rat has not been previously investigated. Methods and Results: The morphological and ultrastructure alterations were tested by transmission electron microscopy, changes in the H2S concentration and the relaxation of the mesenteric secondary artery loop of diab

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8

Cheung, Sau Ha, Wai Kei Kwok, Ka Fai To, and James Yun Wong Lau. "Anti-Atherogenic Effect of Hydrogen Sulfide by Over-Expression of Cystathionine Gamma-Lyase (CSE) Gene." PLoS ONE 9, no. 11 (2014): e113038. http://dx.doi.org/10.1371/journal.pone.0113038.

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9

Thanki, Ketan K., Michael E. Nicholls, Romain Villeger, et al. "Tu1766 - Macrophage Interleukin-10 (IL-10) Production is Dependent on Cystathionine-Gamma-Lyase (CSE) Expression." Gastroenterology 154, no. 6 (2018): S—1013—S—1014. http://dx.doi.org/10.1016/s0016-5085(18)33392-4.

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10

Gaddam, Ravinder, Stephen Chambers, Robin Fraser, et al. "Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis." International Journal of Molecular Sciences 20, no. 13 (2019): 3191. http://dx.doi.org/10.3390/ijms20133191.

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Cystathionine-γ-lyase (CSE) is a hydrogen sulfide (H2S)-synthesizing enzyme that promotes inflammation by upregulating H2S in sepsis. Liver sinusoidal endothelial cells (LSECs) are fenestrated endothelial cells (liver sieve) that undergo alteration during sepsis and H2S plays a role in this process. Substance P (SP) is encoded by the preprotachykinin A (PPTA) gene, and promotes inflammation in sepsis; however, its regulation by H2S is poorly understood. Furthermore, the interaction between H2S and SP in modulating LSEC fenestrations following sepsis remains unclear. This study aimed to investi

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Kolluru, Gopi K., Xinggui Shen, and Christopher G. Kevil. "Reactive Sulfur Species." Arteriosclerosis, Thrombosis, and Vascular Biology 40, no. 4 (2020): 874–84. http://dx.doi.org/10.1161/atvbaha.120.314084.

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Hydrogen sulfide has emerged as an important gaseous signaling molecule and a regulator of critical biological processes. However, the physiological significance of hydrogen sulfide metabolites such as persulfides, polysulfides, and other reactive sulfur species (RSS) has only recently been appreciated. Emerging evidence suggests that these RSS molecules may have similar or divergent regulatory roles compared with hydrogen sulfide in various biological activities. However, the chemical nature of persulfides and polysulfides is complex and remains poorly understood within cardiovascular and oth

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12

Wang, Mingqi, Xinyu Cao, Chang Luan, and Zhengqiang Li. "Hydrogen Sulfide Attenuates Hydrogen Peroxide-Induced Injury in Human Lung Epithelial A549 Cells." International Journal of Molecular Sciences 20, no. 16 (2019): 3975. http://dx.doi.org/10.3390/ijms20163975.

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Lung tissues are frequently exposed to a hyperoxia environment, which leads to oxidative stress injuries. Hydrogen sulfide (H2S) is widely implicated in physiological and pathological processes and its antioxidant effect has attracted much attention. Therefore, in this study, we used hydrogen peroxide (H2O2) as an oxidative damage model to investigate the protective mechanism of H2S in lung injury. Cell death induced by H2O2 treatment could be significantly attenuated by the pre-treatment of H2S, resulting in a decrease in the Bax/Bcl-2 ratio and the inhibition of caspase-3 activity in human l

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13

Islam, Kazi N., David J. Polhemus, Hiroyuki Otsuka, Shashi Bhushan, Jessica M. Bradley, and David J. Lefer. "P7 Activation of nuclear transcription factor-kappaB (NF-kappaB) in cystathionine gamma-lyase (CSE) knockout (KO) mice." Nitric Oxide 39 (May 2014): S18. http://dx.doi.org/10.1016/j.niox.2014.03.057.

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14

King, Adrienne Lester, Shashi Bushan, Benjamin Predmore, et al. "Cystathionine Gamma-lyase (CSE) Deficiency Increases Oxidative Stress and Exacerbates Cardiac Mitochondrial Dysfunction and Myocardial Reperfusion Injury." Free Radical Biology and Medicine 51 (November 2011): S43. http://dx.doi.org/10.1016/j.freeradbiomed.2011.10.106.

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15

Kolluru, Gopi, Bo Wood, Nicky Hall, et al. "Role of vascular cystathionine gamma lyase (CSE) / hydrogen sulfide (H2S) in regulating brain perfusion and cognitive function." Free Radical Biology and Medicine 192 (November 2022): 20–21. http://dx.doi.org/10.1016/j.freeradbiomed.2022.10.017.

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16

Duan, Jiaxiang, Lunli Xiang, Zhen Yang, et al. "Methionine Restriction Prevents Lipopolysaccharide-Induced Acute Lung Injury via Modulating CSE/H2S Pathway." Nutrients 14, no. 2 (2022): 322. http://dx.doi.org/10.3390/nu14020322.

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Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) result in high mortality, whereas effective treatments are limited. Methionine restriction (MR) has been reported to offer various benefits against multiple pathological processes of organ injuries. However, it remains unknown whether MR has any potential therapeutic value for ALI/ARDS. The current study was set to investigate the therapeutic potential of MR on lipopolysaccharide (LPS)-induced ALI and its underlying mechanisms. We found that MR attenuated LPS-induced pulmonary edema, hemorrhage, atelectasis, and alveolar ep

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17

Shen, Yaqi, and Yi Zhun Zhu. "P56 MiRNA-30 regulates the production of endogenous H2S by Cystathionine gamma-lyase (CSE) in primary cardiac myocytes." Nitric Oxide 27 (September 2012): S37. http://dx.doi.org/10.1016/j.niox.2012.08.057.

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18

Ehirchiou, D., T. Chirayath, S. Nasi, et al. "OP0132 POSITIVE ALLOSTERIC MODULATORS (PAMS) OF CYSTATHIONINE GAMMA LYASE (CSE) INCREASE HYDROGEN SULFIDE (H2S) AND INHIBIT NLRP3 ACTIVATION." Annals of the Rheumatic Diseases 84 (June 2025): 116–17. https://doi.org/10.1016/j.ard.2025.05.154.

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19

Greasley, Adam, Yanjie Zhang, Bo Wu, Yanxi Pei, Nelson Belzile, and Guangdong Yang. "H2S Protects against Cardiac Cell Hypertrophy through Regulation of Selenoproteins." Oxidative Medicine and Cellular Longevity 2019 (September 10, 2019): 1–12. http://dx.doi.org/10.1155/2019/6494306.

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Cardiac hypertrophy is defined as the enlargement of the cardiac myocytes, leading to improper nourishment and oxygen supply due to the increased functional demand. This increased stress on the cardiac system commonly leads to myocardial infarction, contributing to 85% of all cardiac-related deaths. Cystathionine gamma-lyase- (CSE-) derived H2S is a novel gasotransmitter and plays a critical role in the preservation of cardiac functions. Selenocysteine lyase (SCLY) has been identified to produce H2Se, the selenium homologue of H2S. Deficiency of selenium is often found in Keshan disease, a con

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20

Medina-Ruiz, Daniella, Berenice Erreguin-Luna, Francisco Luna-Vázquez, Antonio Romo-Mancillas, Alejandra Rojas-Molina та César Ibarra-Alvarado. "Vasodilation Elicited by Isoxsuprine, Identified by High-Throughput Virtual Screening of Compound Libraries, Involves Activation of the NO/cGMP and H2S/KATP Pathways and Blockade of α1-Adrenoceptors and Calcium Channels". Molecules 24, № 5 (2019): 987. http://dx.doi.org/10.3390/molecules24050987.

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Recently, our research group demonstrated that uvaol and ursolic acid increase NO and H2S production in aortic tissue. Molecular docking studies showed that both compounds bind with high affinity to endothelial NO synthase (eNOS) and cystathionine gamma-lyase (CSE). The aim of this study was to identify hits with high binding affinity for the triterpene binding-allosteric sites of eNOS and CSE and to evaluate their vasodilator effect. Additionally, the mechanism of action of the most potent compound was explored. A high-throughput virtual screening (HTVS) of 107,373 compounds, obtained from fo

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21

Wijerathne, Charith U. B., Susara Madduma Hewage, Yaw L. Siow, and Karmin O. "Kidney Ischemia-Reperfusion Decreases Hydrogen Sulfide and Increases Oxidative Stress in the Heart." Biomolecules 10, no. 11 (2020): 1565. http://dx.doi.org/10.3390/biom10111565.

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Patients with acute kidney injury (AKI) have an increased risk of cardiovascular disease. The underlying mechanism of AKI-induced heart injury is not well-understood. Hydrogen sulfide (H2S), at physiological concentrations, has been implicated in cardiovascular protection through redox balance and vessel relaxation. Cystathionine gamma-lyase (CSE) plays an essential role in H2S production in the heart. The present study investigated the effect of AKI on H2S production and oxidative stress in the heart. AKI was induced by kidney ischemia-reperfusion in male and female Sprague-Dawley rats, which

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22

Zong, Yanfang, Yaqian Huang, Siyao Chen, et al. "Downregulation of Endogenous Hydrogen Sulfide Pathway Is Involved in Mitochondrion-Related Endothelial Cell Apoptosis Induced by High Salt." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/754670.

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Background. The study aimed to investigate whether endogenous H2S pathway was involved in high-salt-stimulated mitochondria-related vascular endothelial cell (VEC) apoptosis.Methods. Cultured human umbilical vein endothelial cells (HUVECs) were used in the study. H2S content in the supernatant was detected. Western blot was used to detect expression of cystathionine gamma-lyase (CSE), cleaved-caspase-3, and mitochondrial and cytosolic cytochrome c (cytc). Fluorescent probes were used to quantitatively detect superoxide anion generation and measure thein situsuperoxide anion generation in HUVEC

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23

Sun, Ling, Shuo Sun, Yufen Li, et al. "Potential biomarkers predicting risk of pulmonary hypertension in congenital heart disease: the role of homocysteine and hydrogen sulfide." Chinese Medical Journal 127, no. 5 (2014): 893–99. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20132694.

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Background Pulmonary hypertension (PH) is a common complication of congenital heart disease (CHD). Although risk stratification is vital for prognosis and therapeutic guidance, the need for understanding the role of novel biomarkers cannot be overlooked. The aim of the present study was to investigate the changes of homocysteine and hydrogen sulfide levels and find potential biomarkers for early detection and treatment. Methods Between September 2012 and April 2013, we prospectively collected data on 158 pediatric patients with left to right shunt CHD at our institution. Standard right heart c

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Islam, Kazi N., David J. Polhemus, Hiroyuki Otsuka, et al. "P6 Oxidative stress suppresses expression of cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST) in critical limb ischemia (CLI) patients." Nitric Oxide 39 (May 2014): S17—S18. http://dx.doi.org/10.1016/j.niox.2014.03.056.

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Harvey, Félix, Boluwaji Aromokunola, Sabine Montaut, and Guangdong Yang. "The Antioxidant Properties of Glucosinolates in Cardiac Cells Are Independent of H2S Signaling." International Journal of Molecular Sciences 25, no. 2 (2024): 696. http://dx.doi.org/10.3390/ijms25020696.

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The organic sulfur-containing compounds glucosinolates (GSLs) and the novel gasotransmitter H2S are known to have cardioprotective effects. This study investigated the antioxidant effects and H2S-releasing potential of three GSLs ((3E)-4-(methylsulfanyl)but-3-enyl GSL or glucoraphasatin, 4-hydroxybenzyl GSL or glucosinalbin, and (RS)-6-(methylsulfinyl)hexyl GSL or glucohesperin) in rat cardiac cells. It was found that all three GSLs had no effect on cardiac cell viability but were able to protect against H2O2-induced oxidative stress and cell death. NaHS, a H2S donor, also protected the cells

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Dattilo, Maurizio, Carolina Fontanarosa, Michele Spinelli, Vittorio Bini, and Angela Amoresano. "Modulation of Human Hydrogen Sulfide Metabolism by Micronutrients, Preliminary Data." Nutrition and Metabolic Insights 15 (January 2022): 117863882110653. http://dx.doi.org/10.1177/11786388211065372.

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Background: Hydrogen sulfide (H2S) is a pivotal gasotransmitter networking with nitric oxide (NO) and carbon monoxide (CO) to regulate basic homeostatic functions. It is released by the alternative pathways of transulfuration by the enzymes Cystathionine Beta Synthase (CBS) and Cystathionine Gamma Lyase (CSE), and by Cysteine AminoTransferase (CAT)/ 3-Mercaptopyruvate Sulfur Transferase (3MPST). A non-enzymatic, intravascular release is also in place. We retrospectively investigated the possibility to modulate the endogenous H2S release and signaling in humans by a dietary manipulation with su

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Goshovska, Yulia V., Raisa A. Fedichkina, Volodymyr V. Balatskyi, Oksana O. Piven, Pawel Dobrzyn, and Vadym F. Sagach. "Induction of Glutathione Synthesis Provides Cardioprotection Regulating NO, AMPK and PPARa Signaling in Ischemic Rat Hearts." Life 11, no. 7 (2021): 631. http://dx.doi.org/10.3390/life11070631.

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Glutathione (GSH) is essential for antioxidant defence, and its depletion is associated with tissue damage during cardiac ischemia-reperfusion (I/R). GSH is synthesized by the glutamate-cysteine ligase enzyme (GCL) from L-cysteine, which alternatively might be used for hydrogen sulfide production by cystathionine-gamma-lyase (CSE). Here, we have investigated whether in vivo treatment with L-cysteine and an inhibitor of CSE,D,L-propargylglycine (PAG), can modulate cardiac glutathione and whether this treatment can influence heart resistance to I/R in a Langendorff isolated rat hearts model. Pre

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Huntsman, David. "Abstract IA008: Rare ovarian cancers: the sequelae of specific interactions between cell contexts mutations and microenvironments." Cancer Research 84, no. 5_Supplement_2 (2024): IA008. http://dx.doi.org/10.1158/1538-7445.ovarian23-ia008.

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Abstract There are many pathologically and clinically distinct types of ovarian cancer and uterine cancers. These are not flavors of the same disease nor can they be solely explained by different mutations or other genomic findings; rather each may be thought to represent distinct interactions between cells of origin, mutations, and the microenvironment in which these cancers occur. Although many know gaps remain this may explain many curious features of these cancers. Fors instance, how endometrioid and clear cell carcinomas have similar mutations yet are distinct biologic and clinical entiti

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Hashmi, Syed F., Hassaan Anwer Rathore, Munavvar A. Sattar, et al. "Hydrogen Sulphide Treatment Prevents Renal Ischemia-Reperfusion Injury by Inhibiting the Expression of ICAM-1 and NF-kB Concentration in Normotensive and Hypertensive Rats." Biomolecules 11, no. 10 (2021): 1549. http://dx.doi.org/10.3390/biom11101549.

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Our main objective was to investigate the effect of chronic administration of hydrogen sulphide donor (sodium hydrosulphide) on the expression of intercellular adhesion molecule-1 (ICAM-1) and concentration of nuclear factor-kappa B (NF-kB) in a renal ischemia-reperfusion injury (IRI) model of WKY and L-nitro-arginine-methyl-ester (L-NAME)-induced hypertensive rats. Sodium hydrosulphide (NaHS) was administered intraperitoneally (i.p.) for 35 days while cystathionine gamma lyase (CSE) inhibitor dL-propargylglycine (PAG) was administered at a single dose of 50 mg/kg. Animals were anesthetised us

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Manna, Prasenjit, and Sushil K. Jain. "Hyperglycemia and Hyperketonemia Increase Oxidative Stress and Decrease Cystathionine-Gamma-Lyase (CSE) Activities and H2S Formation in Livers of Type 1 and Type 2 Diabetic Rats." Free Radical Biology and Medicine 53 (November 2012): S96. http://dx.doi.org/10.1016/j.freeradbiomed.2012.10.175.

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Torres-Torres, Johnatan, Salvador Espino-y-Sosa, Raigam Martinez-Portilla, et al. "A Narrative Review on the Pathophysiology of Preeclampsia." International Journal of Molecular Sciences 25, no. 14 (2024): 7569. http://dx.doi.org/10.3390/ijms25147569.

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Preeclampsia (PE) is a multifactorial pregnancy disorder characterized by hypertension and proteinuria, posing significant risks to both maternal and fetal health. Despite extensive research, its complex pathophysiology remains incompletely understood. This narrative review aims to elucidate the intricate mechanisms contributing to PE, focusing on abnormal placentation, maternal systemic response, oxidative stress, inflammation, and genetic and epigenetic factors. This review synthesizes findings from recent studies, clinical trials, and meta-analyses, highlighting key molecular and cellular p

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Nasi, S., I. Bernabei, E. Faure, et al. "POS0617 THE GASOTRANSMITTER HYDROGEN SULFIDE PROTECTS AGAINST CALCIFIC TENDINOPATHY VIA INHIBITION OF LYSYL OXIDASES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 581–82. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2538.

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BackgroundPathological calcification ((PC),i.e.the deposition of calcium-containing crystals) in tendons is a hallmark of calcific tendinopathy (CT), a disease associated with pain, tendon rupture, and disability. Currently, only symptomatic treatments exist for CT and none of them target specifically calcification. Intriguingly, the gasotransmitter H2S has recently emerged as a potential anti-calcifying molecule [1].ObjectivesTo establish in CT the potential anti-calcifying effect of hydrogen sulfide (H2S) and of the H2S-producing enzyme cystathionine gamma lyase (CSE), and the underlying mec

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Rajendran, Saranya, and Christopher G. Kevil. "Abstract 21141: Cystathionine Gamma-Lyase Regulates Autophagy in Ischemic Endothelial Cells." Circulation 136, suppl_1 (2017). http://dx.doi.org/10.1161/circ.136.suppl_1.21141.

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Introduction: Peripheral arterial disease (PAD) is a chronic arterial occlusive disease leading to lower limb ischemia. Autophagy is a cell adaptive response associated with ischemic stress that may act as a double edged sword. It is essential during tissue ischemia, but may also phagocytize more organelles promoting cell death. Hydrogen sulfide (H 2 S), a gasotransmitter predominantly produced in the vasculature via cystathionine-γ-lyase (CSE), play a key regulatory role in the cardiovascular functions. However, role of H 2 S/CSE in autophagy, and its associated impact on ischemic injury is p

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Azeez, Tooyib, Clifford Pierrre, and Justin La Favor. "Cystathionine gamma lyase (CSE) deficiency promotes increased contraction of the corpus cavernosum." Physiology 38, S1 (2023). http://dx.doi.org/10.1152/physiol.2023.38.s1.5731037.

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Cystathionine γ lyase (CSE) is the primary enzyme responsible for hydrogen sulfide (H2S) production in the vasculature. Although, it is known that H2S is a vasodilator systemically, little is known about the effect of CSE on the arteries and tissues responsible for erectile function. Adequate relaxation of the pre-penile arteries and corpus cavernosum are important for effective penile erection, while excessive contraction impedes erectile response. The aim of our study was to determine the effect of CSE deletion on pre-penile vessels and erectile tissue reactivity. We hypothesized that CSE de

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DeRatt, Barbara, Maria Ralat, and Jess Gregory. "Characterization of Cystathionine Beta‐Synthase and Cystathionine Gamma‐Lyase in the Production of Hydrogen Sulfide Biomarkers, Lanthionine and Homolanthionine, in a HepG2 Cell Culture Model." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.1171.5.

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Hydrogen sulfide (H2S) is an essential gasotransmitter with the ability induce vasodilation and exert other cardioprotective effects in‐vivo, yet accurate quantification of H2S is difficult and often erroneous. Proposed biomarkers, lanthionine and homolanthionine, are produced concurrently with H2S by the pyridoxal 5′‐phosphate (PLP) dependent‐transsulfuration enzymes, cystathionine beta‐synthase (CBS) and cystathionine gamma‐lyase (CSE). This study sought to determine the contribution of CBS and CSE in the production of H2S biomarkers in a HepG2 cell culture model. Isotopic tracers, [U‐13C5]

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Peleli, Maria, Kristina S. Lyngso, Frantz Rom Poulsen, Pernille B. L. Hansen, Andreas Papapetropoulos, and Jane Stubbe. "Inhibition of cystathionine‐gamma lyase dampens vasoconstriction in mouse and human intracerebral arterioles." Acta Physiologica, August 9, 2023. http://dx.doi.org/10.1111/apha.14021.

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AbstractAimIn extracerebral vascular beds cystathionine‐gamma lyase (CSE) activity plays a vasodilatory role but the role of this hydrogen sulfide (H2S) producing enzyme in the intracerebral arterioles remain poorly understood. We hypothesized a similar function in the intracerebral arterioles.MethodsIntracerebral arterioles were isolated from wild type C57BL/6J mouse (9–12 months old) brains and from human brain biopsies. The function (contractility and secondary dilatation) of the intracerebral arterioles was tested ex vivo by pressure myography using a perfusion set‐up. Reverse transcriptio

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Al Shaarani, Majd, Jonette Green, James Traylor, Md Shenuarin Bhuiyan, A. Wayne Orr, and Christopher G. Kevil. "The Role of Cystathionine Gamma Lyase and Endothelial Nitric Oxide Synthase for Cardiovascular Homeostasis." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.977.10.

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Nitric oxide (NO) and hydrogen sulfide (H2S) are two important vasoactive gasotransmitters. Both NO and H2S are essential in the genesis, development, repair and remodeling of blood vessels. They also have a cardio‐protective role that stems from their ability to regulate vasodilation, blood pressure and and the growth of new blood vessels. Genetic deficiency of either endothelial NO synthase (eNOS) or Cystathionine γ‐lyase (CSE, one of the genes implicated in H2S synthesis) has detrimental effects on tissue vascularization and vascular repair against shear forces and atherosclerotic changes.

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Kolluru, Gopi Krishna K., John D. Glawe, Sibile Pardue, et al. "Abstract 118: Methamphetamine Causes Endothelial Dysfunction Via Reduction Of Cystathionine Gamma Lyase And Hydrogen Sulfide Bioavailability." Arteriosclerosis, Thrombosis, and Vascular Biology 41, Suppl_1 (2021). http://dx.doi.org/10.1161/atvb.41.suppl_1.118.

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Background: Methamphetamine (METH) is an addictive illicit drug used worldwide that can elicit significant damage on blood vessels resulting in increased inflammation and cardiovascular dysfunction. Recent studies highlight increased prevalence of cardiovascular disease (CVD) and associated complications including hypertension, vasospasm, left ventricular hypertrophy, and coronary artery disease in younger populations due to METH use making cardiovascular complications the second leading cause of death in METH substance users. The purpose of this study is to understand the underlying molecular

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Manrique, Alvaro F., Shyamal C. Bir, Elvis Peter, Rui Wang, and Christopher G. Kevil. "Abstract 272: Impaired Arteriogenesis in Cystathionine Gamma-Lyase (CSE) and Endothelial Nitric Oxide Synthase (eNOS) Mutant Mice." Arteriosclerosis, Thrombosis, and Vascular Biology 32, suppl_1 (2012). http://dx.doi.org/10.1161/atvb.32.suppl_1.a272.

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Introduction: Arteriogenesis is an important process involving remodeling of collateral vasculature during chronic or intermittent tissue ischemia. CSE and eNOS are the two principle enzymes for hydrogen sulfide (H 2 S) and Nitric Oxide (NO) generation. Although role of NO during arteriogenesis is partially known, the role of CSE dependent H 2 S production during arteriogenesis remains unknown. Hypothesis/objective: We sought to determine the role of CSE generated H 2 S on arteriogenesis activity of CSE knockout (CSEKO) mice compared to eNOS knock out (eNOSKO) and wild type (WT) mice during hi

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Leucker, Thorsten Martin, Jae Hyung Kim, Yohei Nomura, Anil Bhatta, Victor Wang, and Deepesh Pandey. "Pharmacological inhibition of endothelial HDAC6 provides protection against atherogenesis through upregulation of cystathionine gamma‐lyase derived hydrogen sulfide." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.1065.14.

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Endothelial cystathionine gamma‐lyase (CSE) molecular mechanisms that control CSE gene expression in vascular endothelium during cardiovascular diseases are unclear. In this study, isolated murine aortic rings exposed to OxLDL (50mg/ml) for 24 hours exhibited impaired endothelial‐dependent vascular relaxation but were protected by adenoviral‐mediated increases in CSE expression. Cultured human aortic endothelial cells (HAECs) that were exposed to OxLDL and intact aortas from atherogenic ApoE knockout mice fed a high‐fat diet for 12 weeks both exhibited reduced CSE mRNA and protein expression.

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Niu, Yaping, Congkuo Du, Changting Cui та ін. "Norswertianolin Promotes Cystathionine γ-Lyase Activity and Attenuates Renal Ischemia/Reperfusion Injury and Hypertension". Frontiers in Pharmacology 12 (14 липня 2021). http://dx.doi.org/10.3389/fphar.2021.677212.

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Cystathionine gamma-lyase (CSE)/hydrogen sulfide (H2S) plays a protective role in cardiovascular diseases including hypertension and ischemia/reperfusion (I/R) injury. This study was aimed to screen natural small molecule compounds that activate CSE activity and then evaluate its effect(s) on kidney I/R injury and hypertension. Applying computer molecular docking technology, we screened the natural small molecule compound norswertianolin (NW)-specific binding to CSE. Using the microscale thermophoresis technology, we confirmed that the Leu68 site was the essential hydrogen bond site of NW bind

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Sanchez-Aranguren, Lissette Carolina, Shakil Ahmad, Irundika H. K. Dias, et al. "Bioenergetic effects of hydrogen sulfide suppress soluble Flt-1 and soluble endoglin in cystathionine gamma-lyase compromised endothelial cells." Scientific Reports 10, no. 1 (2020). http://dx.doi.org/10.1038/s41598-020-72371-2.

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Abstract Endothelial dysfunction is a hallmark of preeclampsia, a life-threatening complication of pregnancy characterised by hypertension and elevated soluble Fms-Like Tyrosine Kinase-1 (sFlt-1). Dysregulation of hydrogen sulfide (H2S) by inhibition of cystathionine γ-lyase (CSE) increases sFlt-1 and soluble endoglin (sEng) release. We explored whether compromise in CSE/H2S pathway is linked to dysregulation of the mitochondrial bioenergetics and oxidative status. We investigated whether these effects were linked to CSE-induced sFlt-1 and sEng production in endothelial cells. Here, we demonst

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Na, Ann-Yae, Jung Jae Jo, Oh Kwang Kwon, et al. "Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-91664-8.

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AbstractGinseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in the liver although patients often self-medicate with ginseng preparations, which may lead to exceeding the recommended dose for long-term administration. Here, we analyzed changes in the hepatic proteins of mouse livers using quantitative proteomics after sub-chronic administration of Korean red ginseng (KRG) extract (control group and 0.5, 1.0, and 2.0 g/kg KRG) using tandem mass tag (TMT) 6‐plex technology. The 1.0 and 2.0 g/kg KRG groups exhib

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Xia, Huijing, Zhen Li, Kyle B. Lapenna, et al. "Abstract 12371: Genetic Deletion of Cystathionine Gamma Lyase in Endothelial Cells Exacerbates Cardiovascular Dysfunction in Heart Failure With Preserved Ejection Fraction." Circulation 144, Suppl_1 (2021). http://dx.doi.org/10.1161/circ.144.suppl_1.12371.

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Background: Endothelial dysfunction has been suggested as a central pathophysiological mechanism in heart failure with preserved ejection fraction (HFpEF). We reported that Cystathionine Gamma Lyase (CSE), one of the 3 hydrogen sulfide producing enzymes, expressed in endothelial cells is critical for maintaining normal endothelial function and protecting against myocardial ischemia/reperfusion injury. However, the role of endothelial CSE in HFpEF remains unknown. Method: Endothelial specific CSE knockout mice (EC-CSE KO, n=15) and CSE flox/flox control animals (n=6) were fed a high-fat diet (6

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Panagiotopoulos, Dimitrios, Theano Andriopoulou, Victoria‐Marina Spanou, et al. "Deficiency of hydrogen sulfide production and pregnancy rate in an experimental model: Association with preterm delivery." American Journal of Reproductive Immunology 90, no. 3 (2023). http://dx.doi.org/10.1111/aji.13764.

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AbstractProblemPro‐inflammatory phenomena drive preterm delivery (PTD). Hydrogen sulfide is a gasotransmitter with anti‐inflammatory properties produced through the activity of the enzyme cystathionine‐γ‐lyase (CSE), and its impact was studied in models of normal delivery and PTD in mice.Method of studyFemale CSE+/+ and CSE−/− mice were mated with male CSE+/+ mice; mating was done with drinking water unsupplemented and supplemented with cysteine. The pregnancy rate was monitored. PTD was induced by the intraperitoneal injection of bacterial lipopolysaccharide (LPS) on day 14.5 of pregnancy. Mi

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Paul, Bindu Diana, and Solomon H. Snyder. "Role of neuronal signaling effector hydrogen sulfide (H₂S) and sulfhydration in Huntington's disease." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.1271.6.

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Hydrogen sulfide (H2S) has joined the ranks of the gasotransmitters, nitric oxide and carbon monoxide as a signaling molecule that modulates a wide spectrum of physiological processes. H2S signals via sulfhydration, wherein it mediates the conversion of −SH groups of reactive cysteine residues on target proteins to −SSH or persulfide groups. H2S is synthesized by cystathionine gamma lyase (CSE), cystathionine beta synthase (CBS) and 3‐mercaptopyruvate sulfurtransferase of the reverse transsulfuration pathway. Aberrant H2S metabolism is involved in the progressive neurodegeneration seen in Hunt

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Aydinoglu, F., K. Gonbe, and N. Ogulener. "The Role of L-Cysteine/H2S Pathway in CaSRs-Mediated Relaxations in Mouse Bladder Tissue." Physiological Research, June 30, 2025. https://doi.org/10.33549/physiolres.935579.

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The activation of Calcium-Sensing Receptors (CaSRs) reduces detrusor activity in bladder tissues. Also, hydrogen sulfide (H2S) produces in bladder tissue and regulates the bladder smooth muscles tone. However, there is no evidence of the interaction between CaSRs and H2S in bladder tissue. The aim of this study is to investigate the possible contribution of L-cysteine/H2S pathway in CaSRs-mediated relaxation responses in isolated mouse bladder tissue. CaCl2 (1, 2, 3, 5, 10 mM) was applied to isolated mouse bladder tissues pre-contracted with carbachol (1 µM). CaCl2-induced relaxations were per

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Ahmad, Akbar, Domokos Gero, Gabor Olah, and Csaba Szabo. "Effect of lipopolysaccharide (LPS)‐induced endotoxemia in mice genetically deficient in either one of the three major hydrogen‐sulfide producing enzymes." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.1271.8.

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Various strategies, targeting the pro‐inflammatory response associated with sepsis have been proposed, without clinical success. We examined the impact of LPS‐induced changes in systemic inflammation, and sulfide expression, metabolism in mice deficient in either one of the three H2S producing enzymes. We injected LPS (10 mg/kg) intraperitoneally (i.p) to wild type (WT) mice, cystathionine‐β‐synthase heterozygous (CBS+/−) mice, cystathionine‐γ‐lyase homozygous (CSE−/−) deficient mice or 3‐mercaptopyruvate sulfurtransferase (3‐MST) mutant mice. After 6 h animals were sacrificed, blood and organ

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Jin, Ruxi, Ruixue Yang, Changting Cui та ін. "Ferroptosis due to Cystathionine γ Lyase/Hydrogen Sulfide Downregulation Under High Hydrostatic Pressure Exacerbates VSMC Dysfunction". Frontiers in Cell and Developmental Biology 10 (3 лютого 2022). http://dx.doi.org/10.3389/fcell.2022.829316.

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Hydrostatic pressure, stretch, and shear are major biomechanical forces of vessels and play critical roles in genesis and development of hypertension. Our previous work demonstrated that high hydrostatic pressure (HHP) promoted vascular smooth muscle cells (VSMCs) two novel subsets: inflammatory and endothelial function inhibitory VSMCs and then exacerbated VSMC dysfunction. However, the underlying mechanism remains unknown. Here, we first identified that aortic GPX4 (a core regulator of ferroptosis) significantly downregulated association with VSMC novel phenotype elevation in SHR rats and hy

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Paul, Bindu Diana, and Solomon H. Snyder. "Neuroprotective actions of hydrogen sulfide (H₂S) and sulfhydration in the brain." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.802.4.

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Hydrogen sulfide (H2S) has emerged as an important signaling molecule joining the ranks of the gasotransmitters, nitric oxide (NO) and carbon monoxide (CO). Analogous to NO, H2S signals via a posttranslational modification termed sulfhydration, wherein H2S mediates the conversion of –SH groups of reactive cysteine residues on target proteins to –SSH or persulfide groups. Ever since its characterization, sulfhydration has been shown to participate in a myriad of physiological processes ranging from vasorelaxation to neuroprotection. Recently we have shown that aberrant H2S metabolism and sulfhy

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