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Dissertations / Theses on the topic 'Cytochrome P-450 Genetic aspects'

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Published: 4 June 2021

Last updated: 28 January 2023

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1

Hansen, Antony James. "Regulation of the expression of phenobarbital-inducible P450 genes." Title page, contents and summary only, 1989. http://web4.library.adelaide.edu.au/theses/09PH/09phh2491.pdf.

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2

Elferink, Lisa Anne. "Characterization of the chicken phenobarbital inducible P450 gene family /." Title page, contents and introduction only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phe39.pdf.

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3

Gerber, Jaclyn. "Cytochrome P450 polymorphisms : relevance in two South African disease populations." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53345.

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Thesis (MSc)--Stellenbosch University, 2003.<br>ENGLISH ABSTRACT: With knowledge of the human genome increasing constantly we are continually faced with new and potentially groundbreaking methods for managing, treating and/or identifying diseases and predisposition to diseases and conditions at a genetic level. The human cytochrome P450 (CYP) super-family of genes code for enzymes that can participate in metabolism of drugs and foreign chemicals and in steroid synthesis and metabolism. Mutations in these genes may contribute to clinically relevant diseases. In this study, the effects of

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4

Wang, Jue. "Regulation and polymorphism of CYP2A6, CYP2B6 and CYP2E1 : functional and clinical aspects /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-650-6/.

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5

Truter, Erika. "Genetic association analysis of polymorphisms in four cytochrome P450 genes, the MDR1 gene and treatment-outcome in Xhosa schizophrenia patients." Thesis, Link to online version, 2007. http://hdl.handle.net/10019/350.

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6

Gooden, Kyna McCullough Schroeder Jane C. "The relationship of uterine leiomyomata and genetic polymorphisms of Cytochrome P-450 1A1, Cytochrome P-450 1B1, and Catechol-O-Methyltransferase." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,303.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Epidemiology, School of Public Health." Discipline: Epidemiology; Department/School: Public Health.

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7

Hu, Yin. "Genetic polymorphism and regulation of cytochrome P450 2E1 /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3690-0.

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8

McLellan, Roman A. "Interindividual differences in xenobiotic-metabolising enzymes : the human genetic factor /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3924-1/.

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9

Oscarson, Mikael. "Genetic polymorphism of human drug metabolising enzymes : structural and functional studies /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3717-6/.

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10

Vadlamuri, Satya Vijayanand. "Genetic evaluation of cytochrome-P450 expression in smoking and nonsmoking women." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=1806.

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Thesis (Ph. D.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains xiv, 150 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 104-120).

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11

Ufer, Mike. "The in-vitro and in-vivo metabolism of the oral anticoagulant phenprocoumon as influenced by genetic polymorphisms of cytochrome P4502C9 /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-172-5/.

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12

Marden, Nicole Yvonne Medical Sciences Faculty of Medicine UNSW. "Transcriptional regulation of the human cytochrome P450 2J2 gene by activator protein-1." Awarded by:University of New South Wales. School of Medical Sciences, 2006. http://handle.unsw.edu.au/1959.4/23360.

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The cytochrome P450 (CYP) superfamily of enzymes catalyses the oxidative metabolism of lipophilic xenobiotics such as drugs and environmental chemicals, and also plays an essential role in the biosynthesis and metabolism of endogenous compounds such as cholesterol and bile acids, vitamins, steroids, arachidonic acid and eicosanoids. Cytochrome P450 2J2 (CYP2J2) is a recently identified member of the human CYP protein family that is highly expressed in the heart, vasculature, liver and other tissues. CYP2J2 metabolises arachidonic acid (AA) into epoxyeicosatrienoic acids (EETs), which have a nu

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13

Ghanem, Mohamed Mohamedy. "Genetic, metabolic, and histopathological studies of particle-associated respiratory alterations." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=3061.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains xiv, 235 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 201-235).

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14

Vong, Sok-wai. "Clinical implications of cytochrome P polymorphisms in patients receiving proton pump inhibitors: aqualitative overview." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31971258.

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15

Chan, Yin-wah, and 陳燕華. "Molecular characterization and expression of cytochrome P450 genes in marine shrimps." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38671414.

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16

Rylander, Rudqvist Tove. "Extrahepatic cytochrome P450s : relation to cancer susceptibility /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-601-4/.

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17

Emery, Maurice George. "Aspects of human CYP 2E1 regulation in health and disease /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/7943.

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18

Vong, Sok-wai. "Clinical implications of cytochrome P polymorphisms in patients receiving proton pump inhibitors a qualitative overview /." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31971258.

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19

Wepener, Ilse. "Pichia pastoris : a viable expression system for steroidogenic cytochrome P450 enzymes." Thesis, Stellenbosch : Stellenbosch University, 2005. http://hdl.handle.net/10019.1/50418.

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Thesis (MSc)--Stellenbosch University, 2005.<br>ENGLISH ABSTRACT: This study describes: I. The cloning of the CVP 19 gene and construction of the intracellular expression vector pPIC3.5K-CYP19. II. The transformation of the yeast, Pichia pastoris with the constructed vector. III. The expression ofP450arom in Pichia pastoris. IV. The determination of enzyme activity and isolation of the protein from the Pichia pastoris cells. V. The expression of P450c 17 in Pichia pastoris. VI. The determination of kinetic constants for the conversion of progesterone to 170H-progesterone and 160H-pro

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20

Sandberg, Lundblad Mia. "Interindividual variation in drug metabolism with focus on polymorphic cytochrome P450 2C9 /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-740-427-9/.

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21

Christensen, Magnus. "Experimental design of phenotyping probe drugs with emphasis on CYP1A2 : their use in studies on genetic and environmental regulation of drug metabolism /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-522-0.

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22

Fernandes, Glaucia Maria de Mendonça. "Investigação molecular e epidemiológica de genes do metabolismo de xenobióticos em pacientes com câncer colorretal esporádico." Faculdade de Medicina de São José do Rio Preto, 2013. http://bdtd.famerp.br/handle/tede/199.

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Made available in DSpace on 2016-01-26T12:51:47Z (GMT). No. of bitstreams: 1 glauciamariamfernandes_dissert.pdf: 1922219 bytes, checksum: f00f507bdc9bcdc1daa422a7965c5c41 (MD5) Previous issue date: 2013-12-12<br>Fundação de Amparo a Pesquisa do Estado de São Paulo<br>Introduction: The xenobiotics are exogenous substances to the organism, as N-nitrosamines, heterocyclic amines (HAs) and polycyclic aromatic hydrocarbons (PAHs), can which result in DNA adducts formation. Polymorphisms in genes involved in the metabolism of xenobiotics could contribute to this process and modulate the developmen

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23

FERNANDES, Mauricio Avelar. "Prevalência de polimorfismos da enzima CYP2D6 em pacientes em terapia com psicotrópicos." Universidade Federal do Maranhão, 2017. http://tedebc.ufma.br:8080/jspui/handle/tede/1928.

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Submitted by Rosivalda Pereira (mrs.pereira@ufma.br) on 2017-09-13T17:47:07Z No. of bitstreams: 1 MauricioFernandes.pdf: 1547228 bytes, checksum: 87d9e63be597d8eaf8f7a783479e1294 (MD5)<br>Made available in DSpace on 2017-09-13T17:47:07Z (GMT). No. of bitstreams: 1 MauricioFernandes.pdf: 1547228 bytes, checksum: 87d9e63be597d8eaf8f7a783479e1294 (MD5) Previous issue date: 2017-04-28<br>Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão<br>INTRODUCTION: In Brazil, it is reported that a great part of the patients who arrive for the primary care service have a

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24

Dong, Linda M. "Genetic variations in calcium and vitamin D related genes and colon cancer risk /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/10926.

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25

Matthias, Christoph. "Molekularbiologische Untersuchungen zum Einfluß genetischer Wirtsfaktoren auf das Erkrankungsrisiko und den Krankheitsverlauf von Patienten mit Plattenephithelkarzinomen im Kopf-Hals-Bereich." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2000. http://dx.doi.org/10.18452/13755.

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Neben Zigarettenrauchen und chronischem Alkoholkonsum scheinen genetische Faktoren bei der Entstehung und im Verlauf der Kopf-Hals-Karzinom Erkrankung bedeutsam zu sein. Genvariationen in den Enzymen, die zigarettenrauch-assoziierte Karzinogene (Glutathion-S-Transferase, GST, Cytochrom P450, CYP) metabolisieren, sowie Genvariationen in immunregulierenden Zytokinen (Tumor-Nekrose-Faktor) könnten Grund dieser Beeinflussung sein. Ziel dieser Studie war es, genetische Wirtsfaktoren zu identifizieren, die das Erkrankungsrisiko und das Tumorverhalten bzw. den Krankheitsverlauf von Plattenepithelkarz

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26

Egbichi, Ifeanyi M. "An investigation into the bioactivity of Sutherlandia frutescens (Cancer bush)." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1777.

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Thesis (MSc (Biochemistry))--University of Stellenbosch, 2009.<br>Sutherlandia frutescens (S. frutescens), sub-species microphylla, is a member of the Fabacea family and is used as a herbal remedy for the treatment of several ailments which include influenza, diabetes, cancer, tuberculosis, chronic fatigue syndrome, rheumatoid arthritis, anxiety, clinical depression, and more recently, those living with human immunodeficiency virus/ acquired immune deficiency syndrome (HIV/AIDS) (1-4). Many of the symptoms of these ailments are associated with a perturbation of the stress response which m

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27

Santos, Juliana da Rocha dos. "Avaliação farmacogenética em pacientes tratados com fármacos antitabagismo." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-17062015-162841/.

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Introdução: A grande variabilidade individual em resposta a fármacos antitabagismo sugere que tratamentos específicos podem ser mais efetivos em determinados subgrupos de fumantes. No contexto de medicina personalizada, o principal objetivo do presente estudo foi avaliar se polimorfismos nos genes CHRNA4, CHRNB2, CYP2B6 e ANKK1 estão associados com a resposta às terapias de cessação tabágica em pacientes provenientes de um programa de assistência ao fumante. Métodos: Estudo de coorte com 483 pacientes fumantes que receberam tratamento farmacológico (vareniclina, vareniclina e bupropiona, bupro

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28

Tanno, Luciana Kase. "Estudo de associação de fatores genéticos em indivíduos com reações de hipersensibilidade tardia induzida por anticonvulsivantes aromáticos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-01122014-113756/.

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Intrdodução: As terapias com anticonvulsivantes de anel aromático (ACA) são freqüentemente associadas a reações adversas. No entanto, reações de hipersensibilidade (RH) não-imediatas (tardias) a estes fármacos são raras, imprevisíveis e geralmente relacionadas à alta morbidade e mortalidade. Foi demonstrado que estas RH aos ACA estão fortemente associadas ao Antígenio de Leucócitos Humanos (HLA)-B*1502 em pacientes chineses e ao HLA-A*3101 em caucasianos. Polimorfismos de genes do metabolismo do Citocromo P450 (CYP)2C9 foram mais associados a estas reações em pacientes orientais. Objetivo: Nos

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29

Hansen, Antony James. "Regulation of the expression of phenobarbital-inducible P450 genes / by Antony James Hansen." Thesis, 1989. http://hdl.handle.net/2440/18876.

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30

Elferink, Lisa Anne. "Characterization of the chicken phenobarbital inducible P450 gene family / by Lisa Anne Elferink (nee Mattschoss)." Thesis, 1987. http://hdl.handle.net/2440/21474.

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31

Dillon, Natalie. "Cytochrome P450 monooxygenase (CYP450) analysis in Lolium rigidum Gaudin / Natalie Dillon." 2001. http://hdl.handle.net/2440/22498.

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"July 2001"<br>Includes bibliographical references (leaves 144-183)<br>xv, 193 leaves : ill., plates (col.) ; 30 cm.<br>Title page, contents and abstract only. The complete thesis in print form is available from the University Library.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Applied and Molecular Ecology, 2002

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32

"Prostacyclin synthase and peroxisome proliferator-activated receptor delta gene polymorphisms: association with type 2 diabetes and functional significance." 2008. http://library.cuhk.edu.hk/record=b5893714.

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Lui, Ming Yin.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2008.<br>Includes bibliographical references (leaves 117-129).<br>Abstracts in English and Chinese.<br>Acknowledgement --- p.I<br>Abstract --- p.III<br>Abstract in Chinese --- p.V<br>List of Abbreviations --- p.VII<br>List of Figures --- p.X<br>List of Tables --- p.XII<br>Table of Contents --- p.XIII<br>Chapter Chapter 1: --- Introduction<br>Chapter 1.1 --- Overview on type 2 diabetes --- p.1<br>Chapter 1.1.1 --- Definition of diabetes --- p.1<br>Chapter 1.1.2 --- Diagnostic criteria --- p.2<br>Chapter 1.1.3 --- Pre

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33

Anuradha, Ramamoorthy. "MECHANISMS OF VARIABILITY IN CYP2D6 METABOLISM: THE CONTRIBUTIONS OF POLYMORPHISMS, COPY NUMBER VARIATIONS AND microRNA." Thesis, 2010. http://hdl.handle.net/1805/2280.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Cytochrome P450 2D6 (CYP2D6) is an important drug metabolizing enzyme that is involved in the metabolism of 20-25% of commonly prescribed drugs. There is interindividual variability in CYP2D6 enzyme activity and this leads to compromised metabolism of many drugs. Genetic and environmental factors explain only a part of the interindividual variability; the other factors that contribute to this variability are largely unknown. Hence, it becomes important to study CYP2D6 to understand the endogenous and exogenous factors that control

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34

Hess, Stephan. "Genetische Marker bei hausärztlichen Patienten mit oraler Antikoagulation." Doctoral thesis, 2004. http://hdl.handle.net/11858/00-1735-0000-0006-B5B5-6.

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