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Journal articles on the topic 'Cytochrome P-450 Genetic aspects'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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1

Setko, N. P., I. I. Berezin, T. V. Gorohova, A. G. Setko, and S. V. Movergoz. "Molecular-genetic and physiological aspects of workers’ adaptation to industrial environment factors." Sanitarnyj vrač (Sanitary Doctor), no. 9 (September 12, 2022): 673–79. http://dx.doi.org/10.33920/med-08-2209-06.

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Molecular genetic studies of cytochrome P-450 genes and assessment of biological adaptation were carried out in 243 machinists and 202 sinkers employed in underground works. It is shown that the processes of adaptation to the factors of the production environment depend on the functionality of regulatory systems and on the characteristics of genetic associations. It was found that 15.3 % of machinists and 15.3 % of sinkers had a satisfactory level of adaptation, tension and an unsatisfactory level — 38.5 % of machinists and 84.6 % of sinkers; only 46.2 % of machinists failed to adapt. At the s

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2

Roumak, V. S., N. V. Umnova, and G. A. Sofronov. "MOLECULAR AND CELLULAR ASPECTS OF DIOXIN TOXICITY." Annals of the Russian academy of medical sciences 69, no. 3-4 (August 21, 2015): 77–84. http://dx.doi.org/10.15690/vramn.v69.i3-4.1000.

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Background: Using methods of molecular toxicology to study dioxin intoxication consequences the contribution was accessed of pathologic alterations induced and manifested by specific biomarkers and ecogenetic effects among Vietnamese population living on contaminated territories. The causes of variability in individual sensitivity to toxic activity were also evaluated. Materials and methods: Individual biomedical indices were compared between those living in contaminated with dioxins (n =8142) and control (n =4421) regions. Dioxin concentrations were measured by high resolution chromato-mass s

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3

Sychev, Dmitry A., Igor N. Sychev, Karin B. Mirzaev, Eric I. Rytkin, Dmitriy V. Ivashchenko, Irina V. Bure, and Vitaliy A. Otdelenov. "Clinical pharmacology technologies for personalization of cardiovascular diseases drug treatment: focus on direct oral anticoagulants." Annals of the Russian academy of medical sciences 74, no. 5 (December 4, 2019): 299–306. http://dx.doi.org/10.15690/vramn1214.

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One of the main causes for adverse reactions development is not taking into account the pharmacokinetics of drugs and the dose. Pharmacokinetics of drugs is mostly defined by the cytochrome P-450 isoenzymes activity, carboxylesterases and many other isoenzymes of drug metabolism, as well as ADME transporters (P-gp etc.) which take part in the process of drug metabolism. The activity of these isoenzymes is defined by the genetic aspects of patients and non-genetic aspects such as comorbidity and drug-drug interactions. The development of complex algorithms for personalization of therapy based o

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4

Resál, T., K. Farkas, and T. Molnár. "P546 The safety and efficacy of the new-generation budesonide-MMX in the aspect of the cytochrome P-450 enzyme genotype." Journal of Crohn's and Colitis 15, Supplement_1 (May 1, 2021): S516. http://dx.doi.org/10.1093/ecco-jcc/jjab076.667.

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Abstract Background Unlike previous forms of budesonide absorbing from the ileal and ascending colon region, the new-generation budesonide-MMX contains a formula, that allows absorption throughout the whole colon. Budesonide is degraded in the liver by cytochrome P450 3A enzyme, but so far, there is no study examining the relationship between the budesonide’s effect and the enzyme activity. CYP3A5 is absent in 90% of the European/caucasian population due to a functional loss mutation (CYP3A5*3), whereas patients with the wild-type CYP3A5*1 allele may be expected to have increased metabolism. T

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5

Savelyeva, Marina I., Ekaterina O. Golubenko, Zhannet A. Sozaeva, Irina V. Poddubnaya, and Vera V. Korennaya. "Analysis of the complications of endocrine therapy with tamoxifen in breast cancer: clinical and pharmacogenetic aspects. Prospective pharmacogenetic cohort study." Journal of Modern Oncology 24, no. 3 (November 25, 2022): 361–67. http://dx.doi.org/10.26442/18151434.2022.3.201783.

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Background. Tamoxifen is the drug of choice in ER-positive breast cancer (BC) therapy for perimenopausal women and one of the endocrine therapy options for menopausal patients. The pharmacological effect of tamoxifen can be influenced by the activity of cytochrome P450 (CYP) enzymes and P-glycoprotein transporters (Pg), and the genes encoding them have broad polymorphism, affecting serum concentrations of active metabolites. This article presents the overall results of a prospective population-based study of the clinical significance of genetic polymorphism of tamoxifen metabolic enzymes and t

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6

Mancilla-Morales, Misael D., Santiago Romero-Fernández, Araceli Contreras-Rodríguez, José J. Flores-Martínez, Víctor Sánchez-Cordero, L. Gerardo Herrera M., María F. López, and Enrico A. Ruiz. "Diverging Genetic Structure of Coexisting Populations of the Black Storm-Petrel and the Least Storm-Petrel in the Gulf of California." Tropical Conservation Science 13 (January 2020): 194008292094917. http://dx.doi.org/10.1177/1940082920949177.

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Estimations on the influence of evolutionary and ecological forces as drivers of population gene diversity and genetic structure have been performed on a growing number of colonial seabirds, but many remain poorly studied. In particular, the population genetic structure of storm-petrels (Hydrobatidae) has been evaluated in only a few of the 24 recognized species. We assessed the genetic diversity and population structure of the Black Storm-Petrel ( Hydrobates melania) and the Least Storm-Petrel ( Hydrobates microsoma) in the Gulf of California. The two species were selected because they are pe

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7

Setsune, J. I., and D. Dolphin. "Organometallic aspects of cytochrome P-450 metabolism." Canadian Journal of Chemistry 65, no. 3 (March 1, 1987): 459–67. http://dx.doi.org/10.1139/v87-080.

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Carbeneiron porphyrins, (N,Fe)-bridged methyleneiron porphyrins, N-alkyliron porphyrins and σ-alkyliron porphyrins have all been shown to occur in nature and to be interconvertible via redox reactions. The chemistry of the naturally occurring iron porphyrins and model iron, cobalt, and ruthenium porphyrins is reviewed emphasizing their organometallic chemistry.

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Miles, J. S., A. W. Munro, B. N. Rospendowski, W. E. Smith, J. McKnight, and A. J. Thomson. "Domains of the catalytically self-sufficient cytochrome P-450 BM-3. Genetic construction, overexpression, purification and spectroscopic characterization." Biochemical Journal 288, no. 2 (December 1, 1992): 503–9. http://dx.doi.org/10.1042/bj2880503.

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1. The gene CYP102 encoding cytochrome P-450 BM-3 and subgenes encoding the cytochrome P-450 and cytochrome P-450 reductase domains have been cloned in Escherichia coli. 2. The protein products of these genes have been overexpressed and purified to homogeneity. 3. The cytochrome P-450 domain is purified in the ferric low-spin state, but is readily converted into the high-spin state by addition of the substrate palmitate (Ks = 1 microM). The cytochrome P-450 reductase domain readily reduces cytochrome c. Mixing the two domains reconstitutes only about one-thousandth of the fatty acid hydroxylas

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9

Cusato, J., D. G. Ribaldone, L. Bertani, M. Antonucci, C. Tomasello, G. P. Caviglia, S. Dibetto, M. Mangia, M. Astegiano, and A. D’Avolio. "DOP20 Genetic of vitamin D as predictor of response to adalimumab in Crohn’s Disease." Journal of Crohn's and Colitis 15, Supplement_1 (May 1, 2021): S058—S061. http://dx.doi.org/10.1093/ecco-jcc/jjab073.059.

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Abstract Background Personalised medicine is the direction towards are converging many efforts of experts in inflammatory bowel diseases (IBDs). The advent of biological drugs, with anti-TNF as first category, have revolutionized the managements of these patients. Unfortunately, several unmet needs are present, like an efficacy in about two third of the patients, onset of side effects like infections, paradoxical IMIDs. Being able to treat with these drugs only patients who will respond would avoid losing time without disease improvement and possible side effects. Vitamin D is important for se

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10

Abdalwahhab, Omir, Asmaa Galal-Khallaf, Samy Abd El-Latif Saber, Alaa GM Osman, and Khaled Mohammed-Geba. "A case study for application of DNA barcoding in identifying species and genetic diversity of fish from the Suez city market, Egypt." Aquatic Living Resources 33 (2020): 11. http://dx.doi.org/10.1051/alr/2020012.

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The Red Sea is one of the key areas of biodiversity in the world. It is a hotspot for speciation and biological invasions. In the current work, a pilot, random sampling trial was carried out to characterize some species in the landings reaching the fish market in Suez city, which is one of the largest fish markets in the Northern Red Sea. Samples of different fish species were subjected to the standard procedures of DNA barcoding, applying the sequencing of the cytochrome oxidase subunit 1 mitochondrial gene (COI). DNA barcoding could successfully identify all the targeted fishes to the specie

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11

Mansour, H., M. Levacher, E. Azoulay-Dupuis, J. Moreau, C. Marquetty, and M. A. Gougerot-Pocidalo. "Genetic differences in response to pulmonary cytochrome P-450 inducers and oxygen toxicity." Journal of Applied Physiology 64, no. 4 (April 1, 1988): 1376–81. http://dx.doi.org/10.1152/jappl.1988.64.4.1376.

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The effects of cytochrome P-450 inducers on O2 toxicity were studied in mice. We first examined three cytochrome P-450 inducers, which differ by their specific tissue affinity: phenobarbital sodium (PB), essentially active in the liver, and 3-methylcholanthrene (3-MC) and beta-naphthoflavone (BNF), which are also active in the lung. Both BNF and 3-MC increased the survival rate and significantly decreased pulmonary edema (pulmonary water and wet-to-dry weight ratio) in C57BL/6J mice exposed to hyperoxia (O2 greater than or equal to 95%), whereas PB had no protective effect. In the second part

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12

DAMON, Marie, Alain FAUTREL, André GUILLOUZO, and Laurent CORCOS. "Genetic analysis of the phenobarbital regulation of the cytochrome P-450 2b-9 and aldehyde dehydrogenase type 2 mRNAs in mouse liver." Biochemical Journal 317, no. 2 (July 15, 1996): 481–86. http://dx.doi.org/10.1042/bj3170481.

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The aim of this study was to investigate the effect of the genetic background on the phenobarbital inducibility of cytochrome P-450 2b-9, cytochrome P-450 2b-10 and aldehyde dehydrogenase type 2 mRNAs in mice. We analysed the basal expression and the phenobarbital inducibility of both cytochrome P-450 mRNAs by semi-quantitative specific reverse transcription-PCR analyses in five inbred mouse strains (A/J, BALB/cByJ, C57BL/6J, DBA/2J and SWR/J). Male mice constitutively expressed cytochrome P-450 2b-9 and cytochrome P-450 2b-10 mRNAs, but a number of differences in their response to phenobarbit

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13

BEREWELA, DIA AHAK M. "The Pharmacogenetics of Cytochrome P-450 and its Effect on Drug Metabolism." Journal of Drug Delivery and Therapeutics 10, no. 5-s (October 15, 2020): 219–23. http://dx.doi.org/10.22270/jddt.v10i5-s.4473.

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Cytochrome P-450 (CYP-450) enzyme plays an essential role in the oxidation of most drugs, and thus it can affect the toxicity and efficacy of many medications. Factors that influence the function and presence of cytochrome have a key impact on the outcomes of therapy. More specifically, characteristics of cytochrome pharmacogenetics and procedures of cytochrome enzymes induction and inhibition can greatly influence the rate of drug biotransformation and the rate of elimination. So, an understanding of genetic variants which are associated with drug responses and illnesses could improve and enh

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14

Hernando-Rodriguez, Miriam, Natalia Rey-Barja, Xabier Marichalar-Mendia, Maria J. Rodriguez-Tojo, Amelia Acha-Sagredo, and Jose M. Aguirre-Urizar. "Role of cytochrome P-450 genetic polymorphisms in oral carcinogenesis." Journal of Oral Pathology & Medicine 41, no. 1 (July 28, 2011): 1–8. http://dx.doi.org/10.1111/j.1600-0714.2011.01067.x.

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15

Kalow, W. "Genetic variation in the human hepatic cytochrome P-450 system." European Journal of Clinical Pharmacology 31, no. 6 (1987): 633–41. http://dx.doi.org/10.1007/bf00541288.

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16

Kapitulnik, J., J. P. Hardwick, J. D. Ostrow, C. C. Webster, S. S. Park, and H. V. Gelboin. "Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats." Biochemical Journal 242, no. 1 (February 15, 1987): 297–300. http://dx.doi.org/10.1042/bj2420297.

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Congenitally jaundiced (jj) Gunn rats had a greater hepatic microsomal content of a cytochrome P-450 isoenzyme, P-450c, than did the non-jaundiced (Jj) rats. No differences in content of P-450b, P-450d and pregnenolone-16 alpha-carbonitrile-induced (PCN) P-450 were found between jj and Jj rats. This is the first demonstration of a constitutive increase in a specific cytochrome P-450 isoenzyme in association with a genetic defect.

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17

Hällström, Inger, and Agneta Blanck. "Genetic regulation of the cytochrome P-450 system in Drosophila melanogaster. I. Chromosomal determination of some cytochrome P-450-dependent reactions." Chemico-Biological Interactions 56, no. 2-3 (December 1985): 157–71. http://dx.doi.org/10.1016/0009-2797(85)90003-1.

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18

Hällström, I. "Genetic regulation of the cytochrome P-450 system in Drosophila melanogaster. II. Localization of some genes regulating cytochrome P-450 activity." Chemico-Biological Interactions 56, no. 2-3 (December 1985): 173–84. http://dx.doi.org/10.1016/0009-2797(85)90004-3.

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19

Daraki, Aggeliki, Sophia Zachaki, Theodora Koromila, Maria Karakosta, Gabriel Pantelias, Vasiliki Aleporou, Constantina Sambani, Panagoula Kollia, and Kalliopi Manola. "the G516 Polymorphism of Cytochrome P450 2B6 Gene in the Susceptibility of De Novo Acute Myeloid Leukemia." Blood 120, no. 21 (November 16, 2012): 2513. http://dx.doi.org/10.1182/blood.v120.21.2513.2513.

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Abstract Abstract 2513 Acute myeloid leukemia (AML) is a heterogeneous disease with well-known clinical and pathological aspects, characterized by the acquisition of somatic mutations in haematopoietic progenitors leading to disruption of differentiation. However, the genetic etiology of AML, which include gene mutations and chromosomal aberrations, is largely unknown. Altered forms of genes that differ by a single nucleotide polymorphisms (SNPs) have been shown to predispose individuals to AML development. Recently it has been reported that interindividual differences based on detoxification

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20

Hällström, Inger. "Genetic variation in cytochrome P-450-dependent demethylation in Drosophila melanogaster." Biochemical Pharmacology 36, no. 14 (July 1987): 2279–82. http://dx.doi.org/10.1016/0006-2952(87)90591-0.

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21

Gates, Brian J., and Neal M. Davies. "AmpliChip for Cytochrome P-450 Genotyping: The Epoch of Personalized Prescriptions." Hospital Pharmacy 41, no. 5 (May 2006): 442–54. http://dx.doi.org/10.1310/hpj4105-442.

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The clinical importance of genetic polymorphisms in drug metabolism is well-known in clinical pharmacotherapy. The first widely available pharmacogenomic microarray technology approved by the Food and Drug Administration as a medical device to clinically genotype genetic polymorphisms in drug metabolism is now available with the launch of AmpliChip technology. This readily accessible clinical microarray test allows the genotyping of cytochrome (CYP) P-450 2D6 and 2C19 and marks a milestone in the epoch of evidence based personalized medicine. Many commonly used drugs are substrates for CYP2D6

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22

Gonder, J. C., R. A. Proctor, and J. A. Will. "Genetic differences in oxygen toxicity are correlated with cytochrome P-450 inducibility." Proceedings of the National Academy of Sciences 82, no. 18 (September 1, 1985): 6315–19. http://dx.doi.org/10.1073/pnas.82.18.6315.

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23

Meier, U. Thomas, and Urs A. Meyer. "Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency." Biochemistry 26, no. 25 (December 1987): 8466–74. http://dx.doi.org/10.1021/bi00399a065.

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24

GUENGERICH, F. PETER, PHILIPPE H. BEAUNE, DIANE R. UMBENHAUER, PERRY F. CHURCHILL, RICHARD W. BORK, GHAZI A. DANNAN, ROBERT G. KNODELL, R. STEPHEN LLOYD, and MARTHA V. MARTIN. "Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans." Biochemical Society Transactions 15, no. 4 (August 1, 1987): 576–78. http://dx.doi.org/10.1042/bst0150576.

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25

SALLEE, FLOYD R., C. LINDSAY DeVANE, and ROBERT E. FERRELL. "Fluoxetine-Related Death in a Child with Cytochrome P-450 2D6 Genetic Deficiency." Journal of Child and Adolescent Psychopharmacology 10, no. 1 (January 2000): 27–34. http://dx.doi.org/10.1089/cap.2000.10.27.

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26

Bilal, Rabiea, Naseem Saud, and Sualeha Riffat. "Rasagiline Pharmacokinetics are affected by cytochrome P-450 1A2 genetic variants in different doses." Proceedings for Annual Meeting of The Japanese Pharmacological Society 93 (2020): 2—O—039. http://dx.doi.org/10.1254/jpssuppl.93.0_2-o-039.

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27

Choi, Jun, Byung-Gun Kim, Ai-Young Lee, Min-Jung Kim, and Won-Young Chey. "Genetic polymorphism of cytochrome P 450 2C9 in diphenylhydantoin-induced cutaneous adverse drug reactions." European Journal of Clinical Pharmacology 60, no. 3 (May 1, 2004): 155–59. http://dx.doi.org/10.1007/s00228-004-0753-0.

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28

Li, Dailin, Roger Belusa, Susana Nowicki, and Anita Aperia. "Arachidonic acid metabolic pathways regulating activity of renal Na+-K+-ATPase are age dependent." American Journal of Physiology-Renal Physiology 278, no. 5 (May 1, 2000): F823—F829. http://dx.doi.org/10.1152/ajprenal.2000.278.5.f823.

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Locally formed arachidonic acid (AA) metabolites are important as modulators of many aspects of renal tubular function, including regulation of the activity of tubular Na+-K+-ATPase. Here we examined the ontogeny of the AA metabolic pathways regulating proximal convoluted tubular (PCT) Na+-K+-ATPase activity in infant and adult rats. Eicosatetraynoic acid, an inhibitor of all AA-metabolizing pathways, abolished this effect. AA inhibition of PCT Na+-K+-ATPase was blocked by the 12-lipoxygenase inhibitor baicalein in infant but not in adult rats and by the specific cytochrome P-450 fatty acid ω-

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29

Sokolov, D. A., Pavel A. Lyuboshevskiy, N. Yu Levshin, A. V. Zhemchugov, and L. V. Kuptsova. "The influence of cytochrome p-450 gene polymorphisms on the tramadol postoperative analgesia effectiveness." Regional Anesthesia and Acute Pain Management 10, no. 3 (September 15, 2016): 192–96. http://dx.doi.org/10.18821/1993-6508-2016-10-3-192-196.

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The effectiveness of postoperative analgesia may be determined by genetic characteristics of patients that affect the pharmacodynamics and pharmacokinetics of drugs. In particular, as a result of the metabolism of tramadol by isoenzyme of cytochrome P-450 is formed O-desmethyltramadol having higher affinity to mu-opioid receptors. The paper explored the effectiveness of analgesia based on tramadol in 48 patients after endoscopic gynecological surgery depending on the presence/absence of polymorphisms of CYP2D6 gene.It was found that 15 patients with polymorphisms С100Т and G1846A had more inte

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30

Vorobyeva, N. A., and A. I. Vorobyeva. "CYTOCHROME P-450 AND VKORC1 GENETIC POLYMORPHISMS IN NENETS - AN INDIGENOUS ETHNIC GROUP IN THE ARCTIC." Human Ecology, no. 9 (September 18, 2020): 11–17. http://dx.doi.org/10.33396/1728-0869-2020-9-11-17.

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31

Mihajlović, Filip, Aleksandar Milosavljević, and Jagoda Gavrilović. "The impact of genetic polymorphism of cytochrome p-450 2C9 and 1A2 isoforms on warfarine metabolism." Medicinski casopis 52, no. 2 (2018): 68–78. http://dx.doi.org/10.5937/mckg52-17406.

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32

Lee, M. S. "Role of genetic polymorphisms related to neurotransmitters and cytochrome P-450 enzymes in response to antidepressants." Drugs of Today 43, no. 8 (2007): 569. http://dx.doi.org/10.1358/dot.2007.43.8.1130447.

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33

Shibata, N., T. Ohnuma, H. Baba, H. Shimada, T. Takahashi, and H. Arai. "Genetic association between cytochrome P-450 2D6 gene polymorphism and plasma concentration of haloperidolin Japanese schizophrenics." Psychiatric Genetics 9, no. 3 (September 1999): 145–48. http://dx.doi.org/10.1097/00041444-199909000-00006.

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34

Katoch, Meenu, M. A. Hussain, and A. Ahuja. "Comparison of SSR and cytochrome P-450 markers for estimating genetic diversity in Picrorhiza kurrooa L." Plant Systematics and Evolution 299, no. 9 (May 5, 2013): 1637–43. http://dx.doi.org/10.1007/s00606-013-0820-z.

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35

von Borstel, R. C., D. F. O'Connell, R. D. Mehta, and U. G. G. Hennig. "Modulation in cytochrome P-420 and P-450 content in Saccharomyces cerevisiae according to physiological conditions and genetic background." Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 150, no. 1-2 (June 1985): 217–24. http://dx.doi.org/10.1016/0027-5107(85)90118-6.

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36

Santos, Jaqueline Rocha Borges dos, Larrysa de Morais Alves da Cruz, Luís Phillipe Nagem Lopes, and Maria Eline Matheus. "Tobacco consumption during the COVID-19 pandemic and pharmacokinetic interaction involving cytochrome P-450 with psychoactive drugs: an integrative review." Research, Society and Development 11, no. 10 (July 28, 2022): e222111032349. http://dx.doi.org/10.33448/rsd-v11i10.32349.

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This integrative review examines tobacco use related to mental disorders in COVID-19 pandemic and potential interactions involving cytochrome P-450 between tobacco and psychotropic drugs. The five steps of the integrative review development process were considered, namely: elaboration of the guiding question, literature search or sampling, evaluation of data, data analysis, interpretation and presentation of results. A literature search was performed in the Medline and Bireme databases, without language restrictions up to May 2021. Forty-seven articles were found with information on COVID-19,

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37

Selvin, Steve. "Cytochrome P450 1A1 Polymorphism and Childhood Leukemia: An Analysis of Matched Pairs Case-Control Genotype Data." Cancer Epidemiology, Biomarkers & Prevention 13, no. 8 (August 1, 2004): 1371–74. http://dx.doi.org/10.1158/1055-9965.1371.13.8.

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Abstract The association between the genotypic frequencies of the cytochrome P450 1A1 polymorphism and the risk of childhood leukemia is explored with the data from a matched case-control study. The data are displayed in a 3 × 3 case-control array, and the discordant pair counts are assessed for quasi-independence, homogeneity, and symmetry. This statistical approach is contrasted to the more typical analysis of matched data based on a conditional logistic model and estimated odds ratios. The statistical analysis of 175 matched pairs (part of a large study of potential environmental/genetic in

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38

Chhun, Stéphanie, Céline Verstuyft, Nathalie Rizzo-Padoin, Guy Simoneau, Laurent Becquemont, Jean François Bergmann, and Stéphane Mouly. "The Cytochrome P-450 2C9/2C19 but Not the ABCB1 Genetic Polymorphism May Be Associated With the Liver Cytochrome 3A4 Induction by Phenytoin." Journal of Clinical Psychopharmacology 32, no. 3 (June 2012): 429–31. http://dx.doi.org/10.1097/jcp.0b013e3182549c0c.

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39

Stapleton, Phoebe A., Adam G. Goodwill, Milinda E. James, and Jefferson C. Frisbee. "Altered mechanisms of endothelium-dependent dilation in skeletal muscle arterioles with genetic hypercholesterolemia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 293, no. 3 (September 2007): R1110—R1119. http://dx.doi.org/10.1152/ajpregu.00410.2007.

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With most cardiovascular disease risk factors, endothelium-dependent dilation of skeletal muscle resistance arterioles is compromised, although with hypercholesterolemia, impairments to reactivity are not consistently observed. Using apolipoprotein E (ApoE) and low-density lipoprotein receptor (LDLR) gene deletion male mouse models of hypercholesterolemia at 20 wk of age, we tested the hypothesis that arteriolar dilation would be maintained due to an increased stimulus-induced production of dilator metabolites via cyclooxygenase and cytochrome P-450 epoxygenase pathways. Arterioles from both s

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40

Haslemo, T., and L. Tanum. "Use of antidepressants in a modern globalized society." Die Psychiatrie 7, no. 03 (July 2010): 162–68. http://dx.doi.org/10.1055/s-0038-1669572.

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SummaryDepression is a highly prevalent condition throughout the world. Ethnicity is reported to influence treatment outcome with antidepressants in a number of ways, including both cultural and genetic factors. Non-genetic factors such as the type of diet, beliefs about depression and attitudes towards treatment with antidepressants are proposed to directly influence medication adherence and the rate of remission. Genetic factors are mainly expressed through inter-individual variance in drug metabolism and must be born in mind when antidepressants are prescribed in a multi-ethnic society. Rec

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41

Sokolov, D. A., Pavel A. Lyuboshevskiy, and A. N. Ganert. "INFLUENCE OF CYTOCHROME P-450 GENETIC POLYMORPHISMS ON THE MAIN AND SIDE EFFECTS OF TRAMADOL IN THE POSTOPERATIVE PERIOD." Regional Anesthesia and Acute Pain Management 11, no. 4 (December 15, 2017): 240–46. http://dx.doi.org/10.18821/1993-6508-2017-11-4-240-246.

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One of the approaches to increasing the effectiveness and safety of postoperative analgesia can be its personification. The goal of the study was to evaluate the efficacy of tramadol analgesia depending on the polymorphisms of the CYP2D6 gene, the cytochrome P-450 isoenzyme, involved in drug biotransformation into the active metabolite. 96 patients with elective endoscopic gynecology procedures were examined. Polymorphisms G1846A and C100T, which reduce the activity of the isoenzyme CYP2D6, were detected, and the intensity of postoperative pain, the autonomic nervous system state by cardiointe

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Yenny, Yenny. "Pharmacokinetic interactions between rifampicin and efavirenz in HIV-TB coinfections." Universa Medicina 28, no. 3 (February 29, 2016): 188–201. http://dx.doi.org/10.18051/univmed.2009.v28.188-201.

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The increased percentage of patients with HIV-TB coinfection leads to inevitable interactions between rifampicin and efavirenz. Efavirenz is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV infection. The use of this drug combination with rifampicin causes problems in determination of the optimal dosage of efavirenz when administered concomitantly with rifampicin. Efavirenz is metabolized by the enzyme cytochrome P-450 (CYP), i.e. the CYP2B6 and CYP3A4 isozymes, of which rifampicin is an inducer. The induction of cytochrome P-450 by rifampicin is mediate

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Zohir, Naguib, Reham Afifi, Asmaa Ahmed, Zinab Aly, Mehry Elsobekey, Heba Kareem, and Rehab Helmy. "Role of CYP2C9, VKORC1 and Calumenin Genotypes in Monitoring Warfarin Therapy: An Egyptian Study." Open Access Macedonian Journal of Medical Sciences 1, no. 1 (December 15, 2013): 76–82. http://dx.doi.org/10.3889/oamjms.2013.015.

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Background: Oral anticoagulant therapy is conditioned by environmental and genetic factors.Objectives: To verify the effect of the calumenin, cytochrome P-450 variants and VKORC1 genetic polymorphisms on the response to warfarin therapy and warfarin dose adjustment.Patients and Methods: We selected fifty warfarin treated patients with dose adjusted at INR value between 2 and 3. PCR-RFLP is used for of calumenin gene polymorphism. Insitu Hybridization was used for identification of VKORC1 promoter and CYP2C9 variants polymorphisms.Results: The warfarin dose in the patients with Calumenin and CY

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Mohammed, HossamY K., YousryZ Al-Zohairy, and Mahmoud AbdEl-Latif Hashish. "The effect of ‘cytochrome P-450 2C9’ and ‘vitamin K epoxide reductase complex 1’ genetic polymorphism upon oral anticoagulation requirements." Al-Azhar Assiut Medical Journal 16, no. 4 (2018): 371. http://dx.doi.org/10.4103/azmj.azmj_91_18.

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Chan, Andrew T., Gregory J. Tranah, Edward L. Giovannucci, David J. Hunter, and Charles S. Fuchs. "A prospective study of genetic polymorphisms in the cytochrome P-450 2C9 enzyme and the risk for distal colorectal adenoma." Clinical Gastroenterology and Hepatology 2, no. 8 (August 2004): 704–12. http://dx.doi.org/10.1016/s1542-3565(04)00294-0.

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Deloria, Laurel, Viola Abbott, Nigel Gooderham, and Gilbert J. Mannering. "Induction of xanthine oxidase and depression of cytochrome P-450 by interferon inducers: Genetic difference in the responses of mice." Biochemical and Biophysical Research Communications 131, no. 1 (August 1985): 109–14. http://dx.doi.org/10.1016/0006-291x(85)91777-2.

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Hlavica, Peter, and Michael Lehnerer. "Some aspects of the role of cytochrome P-450 isozymes in the n-oxidative transformation of secondary and tertiary amine compounds." Journal of Biochemical Toxicology 10, no. 5 (October 1995): 275–85. http://dx.doi.org/10.1002/jbt.2570100508.

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Kahn, GC, AR Boobis, MJ Brodie, EL Toverud, S. Murray, and DS Davies. "Phenacetin O-deethylase: an activity of a cytochrome P-450 showing genetic linkage with that catalysing the 4-hydroxylation of debrisoquine?" British Journal of Clinical Pharmacology 20, no. 1 (July 1985): 67–76. http://dx.doi.org/10.1111/j.1365-2125.1985.tb02800.x.

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Roman, Richard J. "P-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function." Physiological Reviews 82, no. 1 (January 1, 2002): 131–85. http://dx.doi.org/10.1152/physrev.00021.2001.

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Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) and that these compounds play critical roles in the regulation of renal, pulmonary, and cardiac function and vascular tone. EETs are endothelium-derived vasodilators that hyperpolarize vascular smooth muscle (VSM) cells by activating K+channels. 20-HETE is a vasoconstrictor produced in VSM cells that reduces the open-state probability of Ca2+-activat

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Setko, N. P., A. G. Setko, Ekaterina V. Bulycheva, A. V. Tyurin, and E. Yu Kalinina. "Polymorphism of p-450 cytochrome detoxication genes in adolescents depending on the degree of contamination of the organism by heavy metals." Hygiene and sanitation 99, no. 5 (July 7, 2020): 478–82. http://dx.doi.org/10.47470/0016-9900-2020-99-5-478-482.

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Introduction. Changes in the body of children and adolescents aimed at adapting to environmental factors are determined by genetic polymorphism in xenobiotic biotransformation genes, determining the degree of susceptibility of the child’s body to pollutants, which is the basis of modern personalized preventive medicine when managing risks to the health of the child population under the influence of environmental factors. Material and methods. Trace elements, including heavy metals, lead and cadmium, were determined in the hair of 256 practically healthy teenagers by atomic absorption spectroph

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