Relevant bibliographies by topics / Cytotoxic compound

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Cytotoxic compound'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Cytotoxic compound"

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Hamed, Fadil M., and Mohammad H. Mohammad. "Synthesis ,Characterization and invitro evaluation of anticancer activity of new hydroxamicacid basedHDACi containing substituted thaizolesas a cap linking moiety." JOURNAL OF ADVANCES IN CHEMISTRY 13, no. 10 (2017): 5954–61. http://dx.doi.org/10.24297/jac.v13i10.5886.

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The present study was undertaken to synthesize, characterize and evaluate the anticancer activity of new derivatives of hydroxamate –based HDACi having S-subistituted-5-amino1,3,4thadiazole as a cap linking moiety ,with suitable aliphatic linker.The structures and purity of the targeted compounds were confirmed by TLC , FTIR ,H-NMR and mass spectroscopy and their anticancer activity were evaluated by comparative cytotoxic study , Using HeLa nuclear extract and normal embryonic fibroblasts cell lines.All the synthesized compounds shows good anticancer activity, represented by their high rate
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Maher, Mai, Asmaa E. Kassab, Ashraf F. Zaher, and Zeinab Mahmoud. "Novel Pyrazolo[3,4-d]pyrimidines as Potential Cytotoxic Agents: Design, Synthesis, Molecular Docking and CDK2 Inhibition." Anti-Cancer Agents in Medicinal Chemistry 19, no. 11 (2019): 1368–81. http://dx.doi.org/10.2174/1871520619666190417153350.

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Background: Pyrazolo[3,4-d]pyrimidine scaffold was reported to possess potent cytotoxic and CDK2 inhibitory activity as analogue of roscovitine. Objective: To design and synthesize novel 1-(4-flourophenyl)pyrazolo[3,4-d]pyrimidine derivatives as bioisosters of roscovitine with potential cytotoxic and CDK2 inhibitory activity. Methods: A series of novel 1-(4-flourophenyl)pyrazolo[3,4-d]pyrimidines were designed and synthesized. Structural elucidation for all the newly synthesized compounds was achieved through performing MS, 1H NMR, 13C NMR and IR spectral techniques. Eight compounds were scree
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Manzo, Lawaly Maman, Yijuan Cheng, Ling Yang, et al. "Small-scale screening program for the identification of cytotoxic Oxazolo[5,4-d]pyrimidine derivatives based on Whole Cell Viability Assay." Indian Journal of Pharmaceutical and Biological Research 3, no. 02 (2015): 58–65. http://dx.doi.org/10.30750/ijpbr.3.2.6.

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For over last couple of decades, there has been a robust activity aimed towards the discovery of novel anti-cancer therapeutics. An approach to identify starting points for new drug candidates is high throughput screening of compound library collection. In this work, we describe the application of a Tetrazolium-based, 96-well small scale screening assay to screen a mini library of 19 compounds bearing Oxazolo[5,4-d]pyrimidine structures against human umbilical vein endothelial cells. Primary actives identified against HUVEC were retested and the IC50 value compounds were estimated for HUVEC. T
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Nabil, Sara, and Abeer Obaid Al-Dossary. "in vitro Cytotoxic Evaluation of Some New Synthesized Pyridazine Derivatives." Asian Journal of Chemistry 31, no. 3 (2019): 744–50. http://dx.doi.org/10.14233/ajchem.2019.21832.

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A series of novel pyridazine, pyrazoles, pyrimidines derivatives have been synthesized through the reaction of chloropyridazine (1) with p-phenylenediamine to give compound 2. Diazotization of compound 2 followed by coupling with active methylene compounds namely acetylacetone, ethylcyanoacetate and/or ethylacetoacetate afforded novel hydrazons derivatives (4-6). The resulting hydrazons can have been cyclized using hydrazine hydrate and guanidine gave the corresponding pyrazoles (7-9) and pyimidine (10) derivatives. Reaction of compound 2 with acrylonitrile, aromatic aldehyde, p-chloroacetophe
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Sirka, Lütfiye, Hacer Doğan, Mehmet Refik Bahar, et al. "(E)-1-(4-Hydroxyphenyl)-3-(substituted-phenyl) prop-2-en-1-ones: Synthesis, In Vitro Cytotoxic Activity and Molecular Docking Studies." Acta Chimica Slovenica 69, no. 2 (2022): 281–92. http://dx.doi.org/10.17344/acsi.2021.7080.

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A series of chalcone compounds (2–11) were designed and synthesized to determine their cytotoxic effects. The structures of 2–11 were fully characterized by their physical and spectral data. The in vitro cytotoxic effects of 2–11 were evaluated against human ovarian cancer (A2780), breast cancer (MCF-7) and prostate cancer (PC-3 and LNCaP) cell lines. The activity potentials of compounds were further evaluated through molecular docking studies with AutoDock4 and Vina softwares. All the compounds (except compound 5) showed significant cytotoxic effects at high doses in all cancer cell lines. Am
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Hussain, Fahad, Fahad Imtiaz Rahman, Poushali Saha, et al. "Synthesis of Sugar and Nucleoside Analogs and Evaluation of Their Anticancer and Analgesic Potentials." Molecules 27, no. 11 (2022): 3499. http://dx.doi.org/10.3390/molecules27113499.

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Chemical modification of sugars and nucleosides has a long history of producing compounds with improved selectivity and efficacy. In this study, several modified sugars (2–3) and ribonucleoside analogs (4–8) have been synthesized from α-d-glucose in a total of 21 steps. The compounds were tested for peripheral anti-nociceptive characteristics in the acetic acid-induced writhing assay in mice, where compounds 2, 7, and 8 showed a significant reduction in the number of writhes by 56%, 62%, and 63%, respectively. The compounds were also tested for their cytotoxic potential against human HeLa cell
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Polokhina, K. V., D. E. Kytova, A. V. Shtemenko, and N. I. Shtemenko. "Cytotoxic activity of the cluster rhenium compound with ?-alanine ligands." Ukrainian Biochemical Journal 92, no. 1 (2020): 120–26. http://dx.doi.org/10.15407/ubj92.01.120.

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Acar Çevik, Ulviye, Begüm Nurpelin Sağlık, Cankız Mina Ardıç, Yusuf Özkay, and Özlem Atlı. "Synthesis and evaluation of new benzimidazole derivatives with hydrazone moiety as anticancer agents." Turkish Journal of Biochemistry 43, no. 2 (2018): 151–58. http://dx.doi.org/10.1515/tjb-2017-0167.

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Abstract Objectives: Cancer is one of the leading causes of death throughout the world. Current therapy options suffer from the major limitations of side effects and drug resistance. Thus, continuing search for newer and safer anticancer drugs remains critically important. From this point of view, in the present study benzimidazole-hydrazone derivatives were synthesized by aiming at the identification of new chemical entities as potent anticancer agents. Material and methods: A series of 12 new compounds of 4-(5(6)-substituted-1H-benzimidazol-2-yl)-N′thiophen/furan-2-yl-methylene) benzohydrazi
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Huo, Shaojie, Jichun Wu, Xicheng He, Lutai Pan, and Jiang Du. "Two New Cytotoxic Steroidal Alkaloids from Sarcococca Hookeriana." Molecules 24, no. 1 (2018): 11. http://dx.doi.org/10.3390/molecules24010011.

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Two new steroidal alkaloids, named hookerianine A (1) and hookerianine B (2) were isolated from the stems and roots of Sarcococca hookeriana Baill., along with two known compounds, sarcorucinine G (3) and epipachysamine D (4). On the basis of spectroscopic methods and by comparison with literature data, their structures were determined. As well as X-ray crystallography was performed to confirm compound 4. To identify novel antitumor inhibitors, all compounds were performed a CCK-8 assay against five human cancer cell lines SW480, SMMC-7721, PC3, MCF-7 and K562 in vitro. Compound 2 exhibited mo
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Sary, Hanan G., Abdel Nasser B. Singab, and Khaled Y. Orabi. "New Cytotoxic Guaianolides from Centaurea Aegyptiaca." Natural Product Communications 11, no. 6 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100603.

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The ethanol extract of Centaurea aegyptiaca aerial parts afforded two new chlorinated bioactive guaianolides, cenegyptin A (1) and cenegyptin B (2), in addition to four known sesquiterpenes (3-6). Their identities were established on the basis of their spectral data. The cytotoxicity (IC50, μM) of compounds 1-6 were evaluated against hepatic (HEPG2) and laryngeal (HEP2) carcinoma cell lines in comparison with normal fibroblasts (BHK). Compound 1 showed cytotoxic activity against HEPG2 and HEP2 with IC50 values of 7.2 ± 0.04 and 7.5 ± 0.02, respectively. However, compound 2 exhibited only a lim
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Dissertations / Theses on the topic "Cytotoxic compound"

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Wang, Hsiao-Hsien. "Cytotoxic effects of a novel nitric oxide donor compound and oncogenic transformation of a human urothelial cell line." Thesis, University of St Andrews, 1995. http://hdl.handle.net/10023/14088.

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Transitional cell carcinoma of the bladder is commonly encountered in urological practice. It affects people of a relatively young age causing economic and social distress to patients. In order to prevent the disease it is important to understand its pathogenesis. In this study, we have tumorigenically transformed a human urothelial cell by growing cells in a serum free, factor free, chemically defined culture. The tumorigenic property of the cell was determined by the generation of a tumor after inoculation into nude mouse. DNA fingerprinting analysis demonstrated the common back ground of th
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Ekelund, Sara. "Microphysiometry in the evaluation of cytotoxic drugs with special emphasis on the novel cyanoguanidine CHS 828." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5105-5/.

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Brustolin, Leonardo. "Novel antiblastic Ru(III)-, Cu(II)- and Au(III)-based coordination compounds: from rational design, synthesis and physico-chemical characterization to nanoformulation, targeted delivery and in vitro evaluation." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3425843.

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There is an essential contribution of inorganic medicinal chemistry in the pharmacopeia. In particular, platinum-based drugs revolutionized the anticancer chemotherapy, and nowadays they find wide application in the treatment of several solid tumors. Nevertheless, their effectiveness is paralleled with severe side-toxicity and the onset of drug resistance. In order to obtain compounds with a better chemotherapeutic index and increased bioavailability, several metal-based compounds have been designed and investigated in the last decades. On these grounds, we present here the synthesis and chara
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Shoeb, Mohammad. "Cytotoxic compounds from the genus Centaurea." Thesis, Robert Gordon University, 2005. http://hdl.handle.net/10059/2353.

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This thesis, which is divided into four chapters, represents an account on the isolation, identification and the assessment of bioactivity of cytotoxic compounds from the genus Centaurea (Family: Asteraceae alto Compositae), a large genus of about 500 species. The first three chapters deal with an introduction of natural products and Centaurea species, followed by the isolation and characterisation of compounds from twelve Centaurea species. The last chapter describes the bioactivities of extracts and isolated compounds from these species. A total of 45 compounds were isolated from twelve Cent
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Araujo, Raquel Helen Brito de. "Avalia??o do efeito do composto tipo heparina isolado do caranguejo Chaceon fenneri na hemostasia e na morte celular." Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12594.

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Made available in DSpace on 2014-12-17T14:03:39Z (GMT). No. of bitstreams: 1 RaquelHBA_DISSERT.pdf: 1772501 bytes, checksum: 51cea5d11ac1524fb197874e85c15f64 (MD5) Previous issue date: 2012-07-20<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>Heparin is a pharmaceutical animal widely used in medicine due to its potent anticoagulant effect. Furthermore, it has the ability to inhibit the proliferation, invasion and adhesion of cancer cells to vascular endothelium. However, its clinical applicability can be compromised by side effects such as bleeding. Thus, the search for na
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Lindholm, Petra. "Cytotoxic Compounds of Plant Origin – Biological and Chemical Diversity." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5728.

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Brown, Katie Beth. "Cytotoxic Effects of Ruthenium Compounds on Human Cancer Cell Lines." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etd/1992.

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Chemotherapy is the most common cancer treatment. Traditionally, platinum-based drugs are used in chemotherapy. More recently, researchers have focused on ruthenium based compounds as a substitute for the platinum compounds. Ruthenium-based compounds appear to be less toxic to healthy cells than traditional platinum-based compounds. In this study, 7 ruthenium-based compounds were tested on HT-29 (colon) and MCF-7 (breast) human cancer cell lines with the specific aim of determining whether or not any of the ruthenium-based compounds exhibited cytotoxic properties. In addition, levels of vascul
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Cananzi, S. "DESIGN AND SYNTHESIS OF NATURAL COMPOUNDS ANALOGUES WITH CYTOTOXIC ACTIVITY." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150163.

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This Ph.D. work was carried out as a part of project focusing on the search of new naturally-derived topoisomerase I inhibitors as potential antitumor compounds. Topoisomerase I is the target of anticancer drug campthotecin (CPT). First generation analogues of CPT are already approved as anticancer agents in human therapy, and several second and third generation derivatives are well advanced in clinical trials. Nevertheless, identification of new campthotecins or alternative molecular scaffolds endowed with similar properties is highly desirable because CPT derivatives were shown to be worth o
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Levrier, Claire. "Phytochemical and Biological Investigations of Cytotoxic Compounds from Australian Endemic Plants." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367364.

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The lack of a cure for advanced prostate cancer (PCa) highlights the need for better therapies to fight this disease, which is the second most common cause of cancer-related death in men. Nature is a rich source of potent anticancer agents, as 75% of the current drugs are derived from natural products, some being microtubule-targeting drugs like vinblastine and docetaxel. While proven to increase overall survival time of PCa patients, docetaxel treatment ultimately fails in part due to the development of drug resistance, presenting a major clinical challenge, given the limited number of altern
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Felth, Jenny. "Studies of Cytotoxic Compounds of Natural Origin and their Mechanisms of Action." Doctoral thesis, Uppsala universitet, Avdelningen för farmakognosi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-148114.

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Cancer incidence is increasing and novel anticancer drugs with new mechanisms of action are essential for future chemotherapeutic treatment. Natural products have historically played an important role in the development of anti-cancer drugs and have potential to do so also in the future. In this thesis two classes of natural products are identified as possible drug lead candidates, and the mechanisms of their action are elucidated. Initially, in a screening of a compound library for cytotoxic effects in colon cancer cells, natural products with potent activity were identified. Based on their p
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Books on the topic "Cytotoxic compound"

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Wong, Wing-Cheong Wilson. The molecular cytotoxic mechanism(s) of dinitrobenzenes and related compounds in isolated hepatocytes. National Library of Canada, 1991.

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Perry, Philip J. Synthesis and biological evaluation of novel cytotoxic heterocyclic compounds: Furo (2,3-b) naphthoquinones and 2-aryl-4H-3,1-benzoxazin-4-ones. De Montfort University, 1996.

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Salih Istifli, Erman, and Hasan Basri Ila, eds. Cytotoxicity - Definition, Identification, and Cytotoxic Compounds. IntechOpen, 2019. http://dx.doi.org/10.5772/intechopen.77899.

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Istifli, Erman Salih, and Hasan Basri İla. Cytotoxicity: Definition, Identification, and Cytotoxic Compounds. IntechOpen, 2019.

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Gutierrez, Rosa Martha Perez. Handbook of Compounds With Cytotoxic Activity Isolated from Plants. Nova Science Publishers, 2006.

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Wong, Wing-Cheong Wilson. The molecular cytotoxic mechanism(s) of dinitrobenzenes and related compounds in isolated hepatocytes. 1991.

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Coppola, Silvia, and Franco Valenza. Inhalation injury in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0107.

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Inhalation injury represents one of the most serious associated injuries complicating the care of thermally-injured patient. It can result in severe respiratory failure and acute respiratory distress syndrome (ARDS) by three mechanisms—thermal or chemical injury, and impairment of systemic oxygen supply. Thermal injury can cause erythema, ulceration, and progressive, life-threatening oedema, particularly of the upper airways. Chemical injury is due to irritants or cytotoxic compounds, and depends on the material burned, the temperature of the fire, and the amount of oxygen present in the fire
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Parsons, James Frank. Toxic effects in macrophage and mast cell preparations perifused in vitro: Continuous recording of morphologicalchanges and enzyme and mediator release kinetics in the study of rat mast cellresponses to compound 48/80 and particulate cytotoxity in mouse peritoneal macrophages. 1986.

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Book chapters on the topic "Cytotoxic compound"

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Vater, Carol A., and Victor S. Goldmacher. "Antibody–Cytotoxic Compound Conjugates for Oncology." In Macromolecular Anticancer Therapeutics. Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-0507-9_9.

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Chang, M. J. W. "Cytokinetic Effect and Cytotoxic Action of Chromium Compound on Human Fibroblast in Culture." In In Vitro Effects of Mineral Dusts. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70630-1_30.

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Anggraini, Kirana, Dyah Ayu Woro Setyaningrum, Laela Wulansari, Hening Tyas Andayani, Laviany Putri Shihran, and Isra Fauziyyah. "Influence of Extraction Solvents on Capsaicin Compound and Cytotoxic Activity of Piper retrofractum Vahl." In Proceedings of the 4th Borobudur International Symposium on Science and Technology 2022 (BIS-STE 2022). Atlantis Press International BV, 2023. http://dx.doi.org/10.2991/978-94-6463-284-2_89.

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Anggraini, Kirana, Dyah Ayu Woro Setyaningrum, Laela Wulansari, Hening Tyas Andayani, Laviany Putri Shihran, and Isra Fauziyyah. "Effect of Extraction Solvent on Extraction Yield, Cytotoxic Activity and Bioactive Compound in Zingiber officinale Roscoe var rubrum." In Proceedings of the 4th Borobudur International Symposium on Science and Technology 2022 (BIS-STE 2022). Atlantis Press International BV, 2023. http://dx.doi.org/10.2991/978-94-6463-284-2_86.

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Höcker, P., W. Hinterberger, K. Geissler, et al. "Buffy Coat Collection and Incubation with a Cytotoxic Compound (ASTA Z 7557) in Patients with Previously Untreated Chronic Granulocytic Leukemia (CGL)." In 11th Annual meeting of the EBMT. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-40457-7_37.

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Boakye-Appiah, Justice, Belinda Hall, Rajko Reljic, and Rachel E. Simmonds. "Current Progress and Prospects for a Buruli Ulcer Vaccine." In Vaccines for Neglected Pathogens: Strategies, Achievements and Challenges. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-24355-4_5.

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AbstractBuruli ulcer (BU), one of the skin-related neglected tropical diseases (skin NTDs), is a necrotizing and disabling cutaneous disease caused by subcutaneous infection with Mycobacterium ulcerans. Leading on from the World Health Organization’s (WHO) establishment of a global BU initiative in 1998, &gt;67,000 cases of BU have been reported from over 32 countries, mostly from West Africa and Australia. While treatment is currently in the transition period from rifampicin plus streptomycin (injection) to an all-oral regimen, it cannot hope to eradicate this opportunistic environmental path
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Schmitz, Francis J., Bruce F. Bowden, and Stephen I. Toth. "Antitumor and Cytotoxic Compounds from Marine Organisms." In Pharmaceutical and Bioactive Natural Products. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4899-2391-2_7.

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Lee, Kuo-Hsiung. "Plant Phenolic Compounds as Cytotoxic Antitumor Agents." In ACS Symposium Series. American Chemical Society, 1992. http://dx.doi.org/10.1021/bk-1992-0507.ch029.

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Deshmukh, Sunil K., Manish K. Gupta, Ved Prakash, and M. Sudhakara Reddy. "Fungal Endophytes -a Novel Source of Cytotoxic Compounds." In Bioactive Molecules in Food. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-76900-4_13-1.

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Deshmukh, Sunil K., Manish K. Gupta, Ved Prakash, and M. Sudhakara Reddy. "Fungal Endophytes: A Novel Source of Cytotoxic Compounds." In Reference Series in Phytochemistry. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-90484-9_13.

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Conference papers on the topic "Cytotoxic compound"

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Maruschak, A. V., A. M. Eliseykin, and Alexandra Zaushintsena. "ASSESSMENT OF GENOME STABILITY IN WORKERS OF THE COAL-BORNE THERMAL POWER PLANTS OF KUZBASS WITH MICRONUCLEAR TEST IN BLOOD LYMPHOCYTES." In I International Congress “The Latest Achievements of Medicine, Healthcare, and Health-Saving Technologies”. Kemerovo State University, 2023. http://dx.doi.org/10.21603/-i-ic-82.

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Objective: to study the cytotoxic effects in workers of coal-fired thermal power plants.&#x0D; The paper analyzes the cytogenetic and proliferative parameters of blood cells in 50&#x0D; employees of thermal power plants and state district power plants and 50 non-working residents of&#x0D; the Kemerovo region. Data have been obtained on the cytotoxic compound of compounds present in&#x0D; the environment of industrial enterprises at the plant of working coal-fired thermal power plants.
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Ferreira, Leonor, João Morais, Vitor Vasconcelos, and Mariana Reis. "Discovery of a Novel Potent Cytotoxic Compound from Leptothoe sp." In The 7th Iberian Congress on Cyanotoxins/3rd Iberoamerican Congress on Cyanotoxins. MDPI, 2022. http://dx.doi.org/10.3390/blsf2022014046.

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Moralev, A. D., O. V. Salomatina, M. A. Zenkova, and A. V. Markov. "NEW MARKER GENES OF TUMOR CELL RESISTANCE TO DOXORUBICIN AND THE DEVELOPMENT OF DRUG CANDIDATES FOR ITS THERAPY." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-277.

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Key genes associated with tumor cell resistance to doxorubicin (Dox) were identified. The screening of P-glycoprotein (P-gp) inhibiting activity of 8 amides of soloxolone was carried out. Through molecular docking, we demonstrated the ability of compounds to bind the transmembrane domain of P-gp. Hit compound sg-650 enhanced the intracellular accumulation of Rhodamine 123 and Dox, synergistically increased cytotoxic effects of Dox in vitro.
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Kaluđerović, Goran. "MESOPOROUS SILICA AS A VEHICLE FOR ORGANOTIN(IV) COMPOUNDS." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac,, 2021. http://dx.doi.org/10.46793/iccbi21.060k.

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Free Ph3Sn(CH2)nOH (n = 3, 4, 6, 8 and 11) and immobilized organotin(IV) compounds, SBA- 15~Cl|Ph3Sn(CH2)nOH, were prepared and tested against different tumor cell lines. Both compounds and nanomaterials revealed strong cytotoxic potential. SBA-15~Cl|Ph3Sn(CH2)3OH as well as free compound induce caspase triggered apoptosis in human ovarian A2780 cells. Ph3Sn(CH2)6OH and corresponding nanomaterial induced apoptosis in mouse melanoma B16 cells. Survived clones of B16 cells demonstrated phenotypic changes, they differentiate toward melanocytes.
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Milenković, Dejan A., Marko N. Živanović, Milan S. Dekić, Marijana Stanojević Pirković, and Jelena R. Đorović Jovanović. "CYTOTOXIC ACTIVITY AND MOLECULAR DOCKING STUDY OF 4- SUBSTITUTED FLAVYLIUM SALT." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac,, 2021. http://dx.doi.org/10.46793/iccbi21.466m.

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In the present manuscript, the cytotoxic activity of flavylium cation substituted at 4- position with phenyl (FC-4Ph) was tested to two cells lines (human colorectal carcinoma, HCT-116, and human fibroblast lung, MRC-5). In vitro cytotoxicity experiments were performed to elucidate the possible anticancer activity of tested substance. Investigated compound did not show cytotoxic effect on HCT-116 after 24 h, while after 72 h exerted significant effect. A significant selectivity towards colorectal carcinoma cells was observed. On the other hand, this compound did not show any effect on MRC-5 ce
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Đorđević, N., O. Keta, V. Petković, et al. "„In vitro“ biological effects of clonal red wines." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.180dj.

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This study aimed to determine the phenolic compound content, in vitro antioxidative potential, and cytotoxic effects of four red wine samples: a commercial (V) and three clonal wines (V1, V2, and V3). LC/MS-MS, cyclic voltammetry, and MTT assay techniques were employed for this purpose. Results revealed that all wines were rich in phenolic compounds. Clonal wines outperformed the commercial ones in most phenolic compounds (except myricetin). Notably, V2 and V3 showed the highest levels of gallic acid, catechin, and epicatechin. Among them, V3 exhibited superior antioxidative activity. The MTT
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Aicher, Babette, Kerstin Hirschfelder, Rolf Jansen, et al. "Abstract C214: Disorazol Z: A highly cytotoxic natural compound with antitumor properties." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-c214.

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Sudha, S., and M. Masilamani Selvam. "Characterization of cytotoxic compound from marine sediment derived new actinomycete Streptomyces coelicolor strain SU5." In 2011 International Conference on Green Technology and Environmental Conservation (GTEC 2011). IEEE, 2011. http://dx.doi.org/10.1109/gtec.2011.6167695.

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Afthoni, Muhammad Hilmi, Eva Monica, and Rollando Rollando. "Cytotoxic activity of flavonoid compound from endophytic fungus Athelia Rolfsii isolated from Sterculia Quadrifida R.Br bark." In INTERNATIONAL CONFERENCE ON ORGANIC AND APPLIED CHEMISTRY (ICOAC) 2022. AIP Publishing, 2024. http://dx.doi.org/10.1063/5.0193740.

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Franco, Giovanni A. Lineros, Yenny Bueno, Micael Hardy, et al. "Abstract LBA050: Bioenergetic evaluation of Mito-compound Mito-Met as potent cytotoxic agents in gastric cancer." In Abstracts: AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; October 7-10, 2021. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1535-7163.targ-21-lba050.

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Reports on the topic "Cytotoxic compound"

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Sritularak, Boonchoo, Kittisak Likhitwitayawuid, Pithi Chanvorachote, and Varisa Pongrakhananon. Cytotoxic constituents from Dendrobium spp. : Final report. Chulalongkorn University, 2014. https://doi.org/10.58837/chula.res.2014.28.

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The MeOH extracts of Dendrobium pullchellum Roxb. Ex Lind1. And D. ellipsophyllum Tang &amp; wang (Orchidaceae) showed significant cytotoxic activity against human lung cancer cells. Phytochemical study of the whole plant of D. pullchellum Roxb. Ex Lind1 led to the isolation of seven phenolic compounds, namely, chrysotobibenzyl, chrysotoxine, crepidatin, moscatilin, fimbriatone, (-) –shikimic acid and liriodendrin. The whole plant of D. ellipsophyllum Tang &amp; wang yielded ten phenolic compounds indluding moscatilin, 5,7-dihydroxy-chromen-4-one, 4,5-dihydroxy-2,3-dimethoxy-9,10-dihydrophenan
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Yompakdee, Chulee, and Sittiruk Roytrakul. Molecular target of an anti-cancer compound from leaves of Clausena harmandiana (Pierre). Chulalongkorn University, 2016. https://doi.org/10.58837/chula.res.2016.32.

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Clausena harmandiana (Pierre) Guillaumin or Song faa dong (in Thai), is classified in Family Rutaceae. Previous study, a coumarin compound designated CHA-01 was isolated from leave extract of C. harmandiana with inhibitory activity against calcium signaling in a ZDS1 null mutant yeast Saccharomyces cerevisiae (delta zds1). However, not much has been known on biological activity of this coumarin. In the past, some other coumarins were reported to contain anti-cancer activity. The aim of this research was to study molecular mechanism on antiproliferation activity of CHA-01 in Jurkat T cells. The
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Kanner, Joseph, Mark Richards, Ron Kohen, and Reed Jess. Improvement of quality and nutritional value of muscle foods. United States Department of Agriculture, 2008. http://dx.doi.org/10.32747/2008.7591735.bard.

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Food is an essential to our existence but under certain conditions it could become the origin to the accumulative health damages. Technological processes as heating, chopping, mincing, grounding, promote the lipid oxidation process in muscle tissues and meat foodstuffs. Lipid oxidation occurred rapidly in turkey muscle, intermediate in duck, and slowest in chicken during frozen storage. Depletion of tocopherol during frozen storage was more rapid in turkey and duck compared to chicken. These processes developed from lipid peroxides produce many cytotoxic compounds including malondialdehyde (MD
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Banin, Amos, Joseph Stucki, and Joel Kostka. Redox Processes in Soils Irrigated with Reclaimed Sewage Effluents: Field Cycles and Basic Mechanism. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7695870.bard.

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The overall objectives of the project were: (a) To measure and study in situ the effect of irrigation with reclaimed sewage effluents on redox processes and related chemical dynamics in soil profiles of agricultural fields. (b) To study under controlled conditions the kinetics and equilibrium states of selected processes that affect redox conditions in field soils or that are effected by them. Specifically, these include the effects on heavy metals sorption and desorption, and the effect on pesticide degradation. On the basis of the initial results from the field study, increased effort was de
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