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Dissertations / Theses on the topic 'Cytotoxic compound'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Wang, Hsiao-Hsien. "Cytotoxic effects of a novel nitric oxide donor compound and oncogenic transformation of a human urothelial cell line." Thesis, University of St Andrews, 1995. http://hdl.handle.net/10023/14088.

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Transitional cell carcinoma of the bladder is commonly encountered in urological practice. It affects people of a relatively young age causing economic and social distress to patients. In order to prevent the disease it is important to understand its pathogenesis. In this study, we have tumorigenically transformed a human urothelial cell by growing cells in a serum free, factor free, chemically defined culture. The tumorigenic property of the cell was determined by the generation of a tumor after inoculation into nude mouse. DNA fingerprinting analysis demonstrated the common back ground of th

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2

Ekelund, Sara. "Microphysiometry in the evaluation of cytotoxic drugs with special emphasis on the novel cyanoguanidine CHS 828." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5105-5/.

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3

Brustolin, Leonardo. "Novel antiblastic Ru(III)-, Cu(II)- and Au(III)-based coordination compounds: from rational design, synthesis and physico-chemical characterization to nanoformulation, targeted delivery and in vitro evaluation." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3425843.

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There is an essential contribution of inorganic medicinal chemistry in the pharmacopeia. In particular, platinum-based drugs revolutionized the anticancer chemotherapy, and nowadays they find wide application in the treatment of several solid tumors. Nevertheless, their effectiveness is paralleled with severe side-toxicity and the onset of drug resistance. In order to obtain compounds with a better chemotherapeutic index and increased bioavailability, several metal-based compounds have been designed and investigated in the last decades. On these grounds, we present here the synthesis and chara

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4

Shoeb, Mohammad. "Cytotoxic compounds from the genus Centaurea." Thesis, Robert Gordon University, 2005. http://hdl.handle.net/10059/2353.

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This thesis, which is divided into four chapters, represents an account on the isolation, identification and the assessment of bioactivity of cytotoxic compounds from the genus Centaurea (Family: Asteraceae alto Compositae), a large genus of about 500 species. The first three chapters deal with an introduction of natural products and Centaurea species, followed by the isolation and characterisation of compounds from twelve Centaurea species. The last chapter describes the bioactivities of extracts and isolated compounds from these species. A total of 45 compounds were isolated from twelve Cent

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5

Araujo, Raquel Helen Brito de. "Avalia??o do efeito do composto tipo heparina isolado do caranguejo Chaceon fenneri na hemostasia e na morte celular." Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12594.

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Made available in DSpace on 2014-12-17T14:03:39Z (GMT). No. of bitstreams: 1 RaquelHBA_DISSERT.pdf: 1772501 bytes, checksum: 51cea5d11ac1524fb197874e85c15f64 (MD5) Previous issue date: 2012-07-20<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>Heparin is a pharmaceutical animal widely used in medicine due to its potent anticoagulant effect. Furthermore, it has the ability to inhibit the proliferation, invasion and adhesion of cancer cells to vascular endothelium. However, its clinical applicability can be compromised by side effects such as bleeding. Thus, the search for na

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6

Lindholm, Petra. "Cytotoxic Compounds of Plant Origin – Biological and Chemical Diversity." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5728.

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7

Brown, Katie Beth. "Cytotoxic Effects of Ruthenium Compounds on Human Cancer Cell Lines." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etd/1992.

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Chemotherapy is the most common cancer treatment. Traditionally, platinum-based drugs are used in chemotherapy. More recently, researchers have focused on ruthenium based compounds as a substitute for the platinum compounds. Ruthenium-based compounds appear to be less toxic to healthy cells than traditional platinum-based compounds. In this study, 7 ruthenium-based compounds were tested on HT-29 (colon) and MCF-7 (breast) human cancer cell lines with the specific aim of determining whether or not any of the ruthenium-based compounds exhibited cytotoxic properties. In addition, levels of vascul

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8

Cananzi, S. "DESIGN AND SYNTHESIS OF NATURAL COMPOUNDS ANALOGUES WITH CYTOTOXIC ACTIVITY." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150163.

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This Ph.D. work was carried out as a part of project focusing on the search of new naturally-derived topoisomerase I inhibitors as potential antitumor compounds. Topoisomerase I is the target of anticancer drug campthotecin (CPT). First generation analogues of CPT are already approved as anticancer agents in human therapy, and several second and third generation derivatives are well advanced in clinical trials. Nevertheless, identification of new campthotecins or alternative molecular scaffolds endowed with similar properties is highly desirable because CPT derivatives were shown to be worth o

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9

Levrier, Claire. "Phytochemical and Biological Investigations of Cytotoxic Compounds from Australian Endemic Plants." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367364.

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The lack of a cure for advanced prostate cancer (PCa) highlights the need for better therapies to fight this disease, which is the second most common cause of cancer-related death in men. Nature is a rich source of potent anticancer agents, as 75% of the current drugs are derived from natural products, some being microtubule-targeting drugs like vinblastine and docetaxel. While proven to increase overall survival time of PCa patients, docetaxel treatment ultimately fails in part due to the development of drug resistance, presenting a major clinical challenge, given the limited number of altern

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10

Felth, Jenny. "Studies of Cytotoxic Compounds of Natural Origin and their Mechanisms of Action." Doctoral thesis, Uppsala universitet, Avdelningen för farmakognosi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-148114.

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Cancer incidence is increasing and novel anticancer drugs with new mechanisms of action are essential for future chemotherapeutic treatment. Natural products have historically played an important role in the development of anti-cancer drugs and have potential to do so also in the future. In this thesis two classes of natural products are identified as possible drug lead candidates, and the mechanisms of their action are elucidated. Initially, in a screening of a compound library for cytotoxic effects in colon cancer cells, natural products with potent activity were identified. Based on their p

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11

Wareing, Clare Jane. "The role of the glutathione S-transferases in resistance to cytotoxic compounds." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/27616.

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The role that glutathione S-transferases (GST) play in the protection of tumour cells from cytotoxic insult was investigated. The possibility that GST may be involved in a stress-response was also explored. Derived drug-resistant tumour cell lines as well as showing various changes commonly associated with drug resistance, also show overexpression of certain GST. In the majority of drug resistant tumour cell models however, the ability of the drugs against which resistance is seen to act as GST substrates has not been demonstrated. For this reason, the known GST substrate, 1-chloro-2,4-dinitro

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12

Allaker, R. P. "The production of cytotoxic and inflammatory compounds by skin and oral microorganisms." Thesis, University of the West of England, Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355849.

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13

Vashishtha, Sarvesh Chandra. "Mannich bases and other related compounds designed principally as candidate cytotoxic and anticancer agents." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq23886.pdf.

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14

Li, Ka-lei Carrie. "In vitro and in vivo studies of cytotoxic and anti-angiogenic cyclometalated gold(III) and gold(III) porphyrin complexes." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39634577.

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15

Li, Ka-lei Carrie, and 李嘉莉. "In vitro and in vivo studies of cytotoxic and anti-angiogenic cyclometalated gold(III) and gold(III) porphyrin complexes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39634577.

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16

López, Antón Nancy. "Identification of novel mechanisms of action contributing to the biological activity of cytotoxic natural compounds." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-53326.

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17

Perry, Heather N. "Synthesis of compounds capable of producing cytotoxic N3-methyladenine DNA adducts in estrogen receptor positive cells /." Electronic version (PDF), 2007. http://dl.uncw.edu/etd/2007-3/perryh/heatherperry.pdf.

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18

Yeung, On-lit. "In-vitro study on the cytotoxic effects and mechanisms of action of arsenic trioxide on human neuroblastoma cells." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B36899987.

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19

Yeung, On-lit, and 楊安烈. "In-vitro study on the cytotoxic effects and mechanisms of action of arsenic trioxide on human neuroblastoma cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B36899987.

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20

Faustino, Brissos Rosa Maria. "Coordination, organometallic and supramolecular chemistry approaches to the design of metal-based cytotoxic agents." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/544129.

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The discovery of cisplatin and its successful use as chemotherapeutic agent have encouraged the development of metal-based anticancer molecules. The present doctoral research project includes three different chemistry approaches to design new metal-based cytotoxic compounds. Coordination, organometallic and supramolecular chemistry have been used to successfully develop three families of compounds with highly promising biological properties. Copper(II) coordination compounds of various nuclearities have been prepared from new Schiff-base ligands. The complexes strongly interact with DNA with

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21

Tong, Pak-ho. "The cytotoxic effect of arsenic trioxide on human neuroblastoma cell lines and its relationship to MYCN gene status." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42841227.

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22

Ozdogan, Nizamettin. "Hplc-dad Isolation Of Antioxidant Compounds In Aesculus Hippocastanum Bark Extracts And Cytotoxic Effects On Hl-60 Cells." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/3/12608917/index.pdf.

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This study was designed to investigate the cytotoxic and antioxidative properties of Aesculus hippocastanum L. (A. hippocastanum) bark extracts. Dried and powdered barks were extracted in ethanol, methanol, water and ethylacetate at a ratio of 1:6 (w/v). Antioxidative capacity of each extract (ethanol, methanol, water and ethylacetate) were determined by their ability to scavenge 1, 1 -diphenyl-2-picryl-hydrazyl radical (DPPH). Effective concentration (EC50) values were calculated as 0.010 mg/mL 0.011 mg/mL, 0.009 and 0.019 mg/mL, respectively for ethanol, methanol, ethylacetate and aqueous ex

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23

Wood, Timothy Paul. "Identification of key mechanism in the cytotoxic effect of two novel anti-cancer compounds on breast cancer cells." Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/24532.

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Organometallic chemotherapeutic agents, many of which target DNA, have been shown to be effective in the treatment of cancer. With that said though, these compounds have a number of side affects such as nephrotoxicity. Two novel compounds, Ferrocene [ferrocenoyltrichloroacetone] and Rhodium-ferrocene [(1.5 cyclooctadiene)(1-ferrocenyl- 4,4,4-trichloro-1,3-butanedionate], synthesised by the research group of J Swarts (University of the Free State) were evaluated to determine their mechanism of action and their potential use as novel therapeutic agents. It is hypothesized, by merit of their chem

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24

Lee, Daniel E. "Development of Non-Traditional Platinum Anticancer Agents: trans-Platinum Planar Amine Compounds and Polynuclear Platinum Compounds." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3809.

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Development of Non-Traditional Platinum Anticancer Agents: trans-Platinum Planar Amine Compounds and Polynuclear Platinum Compounds By Daniel E. Lee, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2015 Major Director: Nicholas P Farrell, Ph.D., Professor, Department of Chemistry Platinum anticancer compounds with cis geometry, similar to cisplatin, have been explored to circumvent the cisplatin resistance; however, they were not considered broadly active in c

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25

Tong, Pak-ho, and 湯柏豪. "The cytotoxic effect of arsenic trioxide on human neuroblastoma cell lines and its relationship to MYCN gene status." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hdl.handle.net/10722/210315.

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26

Benedetti, Brad. "Drug Design, Biological Activity, and Metabolic Consequences of Cytotoxic Platinum Compounds: Utilizing Fluorescent Tagging to Understand Drug Action and Metabolism." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/195.

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Platinum drugs are among the most commonly used chemotherapeutics for the treatment of testicular, head and neck, ovarian, small cell lung, and colorectal carcinomas. Although the current set of platinum chemotherapeutics has proven somewhat successful, the overall success of platinum based drugs is limited due to acquired drug resistance and a limited range of tumor types that are treatable with the current regime. The development of novel cytotoxic platinum based compounds, both trans- and polynuclear, provides for the promising treatment of clinical platinum drug resistant tumors. While t

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27

Hedner, Erik. "Bioactive Compounds in the Chemical Defence of Marine Sponges : Structure-Activity Relationships and Pharmacological Targets." Doctoral thesis, Uppsala University, Division of Pharmacognosy, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8218.

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<p>Marine invertebrates, in particular sponges, represent a source of a wide range of secondary metabolites, many of which have been attributed various defensive capabilities against environmental stress factors. In this thesis sponge-derived low-molecular peptide-like compounds and associated analogs are investigated for bioactivity and pharmacological targets. </p><p>The compound bromobenzisoxazolone barettin (cyclo[(6-bromo-8-(6-bromo-benzioxazol -3(1H)-one)-8-hydroxy)tryptophan)]arginine) was isolated from the sponge <i>Geodia barretti</i> and its ability to inhibit larval settlement of th

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28

Perry, Philip J. "Synthesis and biological evaluation of novel cytotoxic heterocylic compounds : furo[2,3-b]naphthoquinones and 2-aryl-4H-3,1-benzoxazin-4-ones." Thesis, De Montfort University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391202.

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29

Cox, Christopher I. "In vitro studies on the cellular mechanisms of resistance to cytotoxic compounds, with special reference to multidrug resistance and cancer chemotherapy." Thesis, University of Central Lancashire, 1993. http://clok.uclan.ac.uk/19928/.

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The development of resistance to antineoplastic drugs is a major obstacle in the treatment of cancer. When resistance develops to natural product, lipophilic antitumour agents the resistance is also conferred to structurally and functionally unrelated compounds. This phenomenon is termed multidrug resistance (MDR). The development of MDR in vitro is associated with a host of phenotypic changes which are believed to be involved in the cellular mechanism of MDR. In this study a murine mammary tumour cell line, EMT-6, and the previously uncharacterised doxorubicin-selectetj derived subline were u

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30

Menon, Vijay. "CYTOTOXIC PROPERTIES OF NOVEL PLATINUM COMPOUNDS, BBR3610-DACH AND TRANS-4-NBD IN TUMOR CELLS: CELLULAR EFFECTS OF 1, 2-DACH AND NBD LIGANDS." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3001.

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Platinum-based chemotherapeutics are used for the treatment of a wide range of cancers and a number of attempts have been made toward developing compounds with better cellular stability and similar or enhanced cytotoxicity as compared to their predecessors. The first part of the work reported here focuses on the cellular effects of the metabolically stable dinuclear platinum compound, BBR3610-DACH. Comet assay showed this compound to form interstrand crosslinks, a highly toxic DNA lesion in HCT116 cells, at equimolar concentrations to its parental compound, BBR3610. Cell cycle studies showed

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31

Stein, Erika Mattos. "Barcode e bioprospecção de metabólitos das algas marinhas Laurencia aldingensis, L. dendroidea e Laurenciella sp. (Ceramiales, Rhodophyta)." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-19102016-155122/.

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A natureza e diversidade das estruturas químicas com atividade farmacológica que se tem encontrado nos organismos marinhos justificam a busca por novos compostos que são de interesse nas mais diversas áreas de aplicação. As espécies de macroalgas vermelhas, em especial Laurencia spp., merecem destaque pela enorme variedade de terpenos e acetogeninas que produzem, sendo consideradas de grande potencial na produção de novos fármacos. O estudo de seus constituintes pode fornecer importantes subsídios para a quimiotaxonomia, ecologia química, caracterização das espécies e avaliação do potencial bi

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32

Rath, Sebastian. "Anti-angiogenic effects of cytotoxic, microbial derived compounds - Evaluation of the tubulin inhibitor pretubulysin and its derivatives and characterization of the v-ATPase inhibitor concanamycin A." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-149868.

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Rath, Sebastian [Verfasser], and Stefan [Akademischer Betreuer] Zahler. "Anti-angiogenic effects of cytotoxic, microbial derived compounds - Evaluation of the tubulin inhibitor pretubulysin and its derivatives and characterization of the v-ATPase inhibitor concanamycin A / Sebastian Rath. Betreuer: Stefan Zahler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1027669530/34.

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34

Dhanjal, Perminder. "Investigation of the species differences and cytotoxic effects of coumarin and measurement of the cyctotoxic effects of various compounds in freshly isolated hepatocytes using several tests with particular interest in the MTT reduction assay freshly." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281599.

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35

Talag, Agela Hussain Mohammed. "Phytochemical investigation and biological activities of Sanicula europaea and Teucrium davaeanum : isolation and identification of some constituents of Sanicula europaea and Teucrium davaeanum and evaluation of the antioxidant activity of ethanolic extracts of both plants and cytotoxic activity of some isolated compounds." Thesis, University of Bradford, 2016. http://hdl.handle.net/10454/14482.

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The aim of this research was to investigate the phytochemistry of two species Sanicula europaea and Teucrium davaeanum which are traditionally used in treatment of wounds. Four compounds were isolated from the 80% methanolic extract of S. europaea; bis-(2-ethylhexyl) phthalate (1), palmitic acid (2), rosmarinic acid (3), saniculoside N (4). Compounds 1 and 2 were isolated for the first time from this species. The structure elucidation of the isolated compounds was on the basis of 1D, 2D NMR spectroscopy and mass spectrometry measurements. Two compounds were isolated from the crude glycosides e

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Ljiljana, Janjušević. "Biološka aktivnost i hemijski sastav ekstrakata odabranih autohtonih makrogljiva." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2017. https://www.cris.uns.ac.rs/record.jsf?recordId=104929&source=NDLTD&language=en.

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Prema postavljenim ciljevima u ovoj doktorskoj disertaciji sakupljeno je i determinisano ukupno sedam vrsta autohtonih gljiva sa područja Fru&scaron;ke gore, Tare i  Vr&scaron;ačkog brega, pet lignikolnih ‐ <em>Bjerkandera adusta</em>, <em>Pleurocybella  porrigens</em>, St<em>ereum hirsutum, Stereum subtomentosum</em> i Trametes versicolor, i dve  terikolne ‐ <em>Amanita  strobiliformis</em> i Hydnum repandum. Utvrđena je  njihova biolo&scar

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Lin, Yuan-Ta, and 林遠達. "Studies of Compound 462-5 Caused Cytotoxic Effects on Human Hepatoma Cells." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/57840866321616322538.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>88<br>Cancer is a serious health problem in human. Development of anticancer drugs from natural products is one of the important chemotherapy. A compound 176 was isolated from the heartwood of Taiwania cryptomerioides Hayata, and it showed strong cytotoxicity to several tumor cells. Continuation of screening cytotoxic compounds against human hepatoma cells from structure derivatives of 176, we found compound 462-5 shown cytotoxicity in human hepatoma cells, Hep 3B/T2 but not in Hep G2/A2. In this thesis, in vitro, I compared the cytotoxic effect of compo

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Ho, Pai-Jiun, and 何百峻. "Characterizing the Mechanism of Compound 176 caused Cytotoxic Effects on Human Hepatoma cell line HepG2/A2." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/71378609393996905863.

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碩士<br>國立陽明大學<br>生物化學研究所<br>88<br>Using natural products as a source for screening anticancer drugs, we found the cytotoxic compound 176 extracted from heartwood of Taiwania cryptomerioides Hayata. The tumorigenicity of Hep3B/T2 cells in nude mice was suppressed by treatment of compound 176. We found that compound 176 disrupted microtubule formation and caused cell arrest at G2/M phase. Detection of micronucleation and DNA fragmentation indicated that compound 176 causes cell death by inducing apoptosis. Using human hepatoma cell line HepG2/A2 as a model, we try to find out relationships betwee

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Visser, Suzaan. "The toxicity and therapeutic index of a methotrexate polymeric compound, D-85." Thesis, 2007. http://upetd.up.ac.za/thesis/available/etd-05122008-133405.

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Chang, Hsueh-Ling, and 張雪玲. "The cytotoxic effect and molecular mechanism of new flavonoid compound, protoapigenone, against ovarian and prostate cancer cells." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/05216314713516401077.

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博士<br>高雄醫學大學<br>天然藥物研究所<br>97<br>In order to develop the application of nature products on cancer therapy, we isolated a novel flavonoid, protoapigenone, from the methanol extract of Thelypteris torresiana (Gaud.) Alston (Thelypteridaceae). The cytotoxic results indicated that protoapigenone showed the significantly cytotoxic activities toward human ovarian cancer cell lines (MDAH-2774, SKOV3), human cervical cancer cell lines (HeLa, C33A), human breast cancer cell lines (T47D, MCF-7) and human prostate cancer cell line (LNCap). Compared the data with immortalized human breast cancer cell line

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Taiwo, Bamigboye J., Amos A. Fatokun, O. O. Olubiyi, O. T. Bamigboye-Taiwo, Heerden F. R. van, and Colin W. Wright. "Identification of compounds with cytotoxic activity from the leaf of the Nigerian medicinal plant, Anacardium occidentale L. (Anacardiaceae)." 2017. http://hdl.handle.net/10454/11940.

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Yes<br>Cancer is now the second-leading cause of mortality and morbidity, behind only heart disease, necessitating urgent development of (chemo)therapeutic interventions to stem the growing burden of cancer cases and cancer death. Plants represent a credible source of promising drug leads in this regard, with a long history of proven use in the indigenous treatment of cancer. This study therefore investigated Anacardium occidentale, one of the plants in a Nigerian Traditional Medicine formulation commonly used to manage cancerous diseases, for cytotoxic activity. Bioassay-guided fraction

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42

Al, Otaibi Ahmed Abdullah. "Application of green chemistry approaches to cytotoxic compounds." Thesis, 2018. http://hdl.handle.net/1959.13/1383620.

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Research Doctorate - Doctor of Philosophy (PhD)<br>The specific synthesis of organic compounds requires careful control of reaction parameters conditions, such as temperatures, pressure and solvent. In the recent years, room temperature ionic liquids (RTILs) have been the subject of considerable interest and widely used in organic synthesis. Ionic liquids were used throughout this study in an effort to optimise and development of a variety of synthetic pathways to cytotoxic compounds. The use of ionic liquids was coupled with microwave and flow chemistry technologies.

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Ola, Antonius. "Molecular identification of cytotoxic compounds from a marine organism." Thesis, 2009. https://researchonline.jcu.edu.au/8184/1/01front.pdf.

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The marine world has become an important source of anticancer lead drugs with novel mechanisms of action. Many of these are in active phase I or phase II clinical trials while Yondelis in 2007 was approved for clinical use for the treatment of advanced sarcoma. This study aims to identify the molecular structure of pharmacologically active metabolites from tropical marine organisms. The study of pharmacological activity was focused on discovering novel cytotoxic compounds with potential as anticancer agents. Cytotoxicity was assessed in vitro using the P388D1 mouse lymphoma cell line.

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"Cytotoxic Effects of Ruthenium Compounds on Human Cancer Cell Lines." East Tennessee State University, 2008. http://etd-submit.etsu.edu/etd/theses/available/etd-1107108-074625/.

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45

tsai, Pei-Hsun, and 蔡珮熏. "Cytotoxic Mechanism of Quinoline-Derived Compounds in Human Prostate Cancer." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/61873093426763527250.

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碩士<br>高雄醫學大學<br>醫學系生物化學科碩士班<br>103<br>Although hormone-sensitive prostate cancer could be treated by hormone therapy, it will eventually progress to castration-resistant prostate cancer (CRPC).The chemotherapeutic agent, docetaxel has been used as a prostate chemotherapy drug for years. Significant outcome has been observed in CRPC patients, but most of them will ultimately develop docetaxel resistance. Hence, to understand the mechanism behind development of drug resistance has become imperative and important. Previous research found that the docetaxel-resistant cell line PC/DX 25 expresses a

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Kudumela, Refilwe Given. "Isolation, characterisation and cytotoxic effects of antibacterial and antioxidant compounds from selected medicinal plants." Thesis, 2017. http://hdl.handle.net/10386/2208.

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Thesis (MSc. (Microbiology)) -- University of Limpopo, 2017<br>This study was aimed at isolating and evaluating the antibacterial, antioxidant and cytotoxic effects of active compounds from selected medicinal plant species. The biological activities and cytotoxic effects of Commelina africana, Dombeya rotundifolia, Elephantorrhiza elephantina and Schkuhria pinnata were investigated based on their traditional uses. The plants were extracted with different solvents of varying polarities. Methanol was the best extractant with the highest yield. The presence of different phytoconstituents was scre

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Yang, Sheng-Huei, and 楊勝惠. "Cytotoxic mechanisms of peptide ( CTX III ) and synthetic compounds ( IQDMA / THDA ) against Leukemia K562 cells." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/95197082374124945232.

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博士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>96<br>Apoptosis plays an important role in the regulation of cellular activities in eukaryotes. Three predominant apoptotic pathways are the mitochondria-mediated intrinsic pathway, the death receptor-induced extrinsic pathway and apoptotic signalling evoked by endoplasmic reticulum (ER) stress. The mitochondria-mediated intrinsic pathway involves the release of the mitochondrial protein cytochrome c, resulting in activation of caspase 9. The receptor-induced extrinsic pathway involves cellular ligands, such as Fas ligand and tumour necrosis factor, and results in

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Bieda, Ruth [Verfasser]. "Design, DNA interaction and biological function of cell selective cytotoxic Rh(III) compounds / Ruth Bieda." 2010. http://d-nb.info/1007402865/34.

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Fedia, Souilem. "Wild mushrooms and their mycelia as sources of bioactive compounds: antioxidant, anti-inflammatory and cytotoxic properties." Master's thesis, 2016. http://hdl.handle.net/10198/14060.

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Mestrado com dupla diplomação com o High Institute of Biotechnology of Monastir (ISBM), Tunisia<br>Mushrooms are an important source of natural compounds with acknowledged bioactivity. Pleurotus eryngii (DC.) Quél., in particular, is widely recognized for its organoleptic quality and favorable health effects, being commercially produced in great extent. On the other hand, Suillus bellinii (Inzenga) Watling is an ectomycorrhizal symbiont, whose main properties were only reported in a scarce number of publications. Some current trends point toward using the mycelia and the culture media as poten

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Nguyen, Van Tang. "Bioactive compounds, antioxidant and cytotoxic capacities of two Vietnamese medicinal plants: Phyllanthus amarus and Paramignya trimera." Thesis, 2018. http://hdl.handle.net/1959.13/1383681.

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Research Doctorate - Doctor of Philosophy (PhD)<br>Phyllanthus amarus (P. amarus) is known as a traditional herbal plant, which has been used for the prevention and treatment of various chronic diseases such as hepatitis, diabetes and cancer, while Paramignya trimera (P. trimera) is a medicinal plant that has been used for the treatment of chronic ailments, particularly cancer and cancer-like diseases. To date, little research on the optimization of drying and extraction conditions for obtaining the highest phytochemical content and pharmacological capacity from the P. amarus and P. trimera ha

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